Abstract: A multifunctional polymerizable ionic liquid is described comprising an anion and a cationic group having at least two ethylenically unsaturated polymerizable groups, each bonded to the cationic group via a divalent non-alkyl linking group. The multifunctional linking groups independently comprise a heteroatom such as oxygen or nitrogen. The linking groups may independently comprise one or more linkages such as an amide, urea, and more typically a urethane or ester linkage. The ethylenically unsaturated polymerizable groups are typically (meth)acrylate groups. Coatings and coated articles are also described.

Abstract: A water soluble polyvinyl alcohol copolymer having a diad syndiotacticity of greater than about 60% and less than about 70%. In some embodiments, the water soluble polyvinyl alcohol copolymer is soluble in water at a concentration of at least 1 wt % at a temperature of less than 100° C. In other embodiments, the composition is soluble in water at a concentration of at least 5 wt % at a temperature in the range from about 90° C. to less than 100° C. The high solubility of the high syndiotactic poly vinyl alcohols disclosed herein may provide various advantages as described herein, including ease of processing and decreased use of harmful solvents.

Abstract: The present invention provides a hydrogenated block copolymer which has an excellent balance in a transparency, optical property, flexibility, mechanical property, moldability, heat resistance, gas barrier property, low moisture absorbency and non-adsorptive property of chemical. Also, the present invention has an object to provide a resin composition containing the hydrogenated block copolymer as a resin component, and a film and container containing the composition. The present invention relates to a hydrogenated block copolymer containing a Block A of a hydrogenated vinyl aromatic polymer and a Block B of a polymer containing isobutylene.

Abstract: A curable resin composition which contains a curable resin (A) having two or more polymerizable unsaturated bonds in a molecule, and polymer microparticles (B), and which optionally further contains an epoxy resin (C) and a low-molecular-weight compound (D) having a molecular weight less than 300 and having at least one polymerizable unsaturated bond in a molecule, wherein the content of component (B) is 1 to 100 parts by mass per 100 parts by mass of the sum of component (A) and component (D), the content of the epoxy resin (C) is less than 0.5 parts by mass per 100 parts by mass of the sum of component (A) and component (D), component (A) has an epoxy (meth)acrylate content less than 99 parts by mass per 100 parts by mass of the whole component (A), and component (B) has been dispersed in the state of primary particles in the curable resin composition.

Abstract: The invention pertains to a process for cryogenic milling mixtures of (per)fluoroelastomers and semicrystalline thermoplastic VDF polymers, and to free-flowing micronized pellets obtainable therefrom, said micronized pellets advantageously yielding, after extrusion and compounding, excellent mechanical properties, even improved over those of base fluoroelastomer matrix.

Abstract: A supercritical carbon dioxide-assisted solid-phase grafting modification method for polypropylene, comprises swelling polypropylene for 0.5 to 10 hours in supercritical carbon dioxide having dissolved vinyl monomer and an initiator, then slowly relieving the pressure; moving the polypropylene that has undergone the swelling process into a reaction kettle, and adding xylene as an interface agent, the mass of xylene being 1% of the polypropylene; increasing the temperature to between 65° C. and 165° C. under normal pressure, and reacting 1 to 10 hours to obtain modified polypropylene; the swelling permeation temperature during the swelling process is from 31° C. to 60° C., the swelling pressure is from 7.5 to 12 MPa; the initiator is an azo compound or a peroxide. In the present method, the grafting rate reaches 5.4%, the thermal property, polarity, and mechanical property all improve substantially, and hydrophilic property is substantially enhanced.

Abstract: This invention relates to a reaction product obtained by ring-opening metathesis polymerization of norbornene ketones functionalized with the residual portion of a vinyl terminated macromonomer.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.

Abstract: This invention relates to polyethylene copolymers comprising ethylene and vinyl terminated macromonomers. The polyethylene copolymers are achieved by copolymerization of ethylene and vinyl terminated macromonomers in a polymerization reactor, particularly in high yields and with a wide range of VTM molecular weights, that can be made at commercial rates.

Abstract: An ethylenic polymer comprising amyl groups from about 0.1 to about 2.0 units per 1000 carbon atoms as determined by Nuclear Magnetic Resonance and both a peak melting temperature, Tm, in ° C., and a heat of fusion, Hf, in J/g, as determined by DSC Crystallinity, where the numerical values of Tm and Hf correspond to the relationship Tm?(0.2143*Hf)+79.643. An ethylenic polymer comprising at least one preparative TREF fraction that elutes at 95° C. or greater using a Preparative Temperature Rising Elution Fractionation method, where at least one preparative TREF fraction that elutes at 95° C. or greater has a gpcBR value greater than 0.05 and less than 5 as determined by gpcBR Branching Index by 3D-GPC, and where at least 5% of the ethylenic polymer elutes at a temperature of 95° C. or greater based upon the total weight of the ethylenic polymer.

Abstract: The present invention relates to a process for the preparation of sevelamer, in particular sevelamer hydrochloride and sevelamer carbonate/bicarbonate, by means of a process that allows sevelamer to be obtained with good yields and using conventional reactors, without requiring to use specific and expensive equipment.

Abstract: A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3? or 5? end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.

Abstract: Polymers and copolymers having one or more aliphatic polyester groups or blocks. For example, the aliphatic polyester groups or blocks can be derived from a caprolactone such as, for example, ?-caprolactone. The polymers and copolymers can have desirable properties such as, for example, improved solubility and improved thermal properties.

Abstract: The disclosure relates to a process that includes blending a polyimide resin and a primary alky amine organic compound to produce an aryl amine functionalized polyimide, having aryl amine functionality in excess of any anhydride functionality. The polyimide resin can have a weight average molecular weight (Mw) from 5,000 to 100,000 daltons. The organic compound can include at least one primary aliphatic amine without a direct linkage of a nitrogen to an aryl group and without a functionality selected from a halogen functionality, a hydroxyl functionality, a sulfonic acid functionality, a sulfonic acid salt functionality, and combinations thereof. The disclosure also relates to alkyl imide functionalized polyimides also with aryl amine functionalized polyimides, having aryl amine functionality in excess of any anhydride functionality and articles produced therefrom.

Abstract: In one aspect, the invention relates to recycled polyethylene terephthalate compositions, fibers and articles produced therefrom, and methods for producing same. In a further aspect, the invention relates to homogenized post-consumer polyethylene terephthalate. In a further aspect, the invention relates to extruded polymer compositions, polymer mixtures, fibers, and/or Bulked Continuous Filament fibers comprising post-consumer polyethylene terephthalate. In a further aspect, the invention relates to processes for preparing recycled polyethylene terephthalate compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Rotational cast polyurethane composition prepared from a prepolymer composition comprising: a) an isocyanate-terminated polyurethane prepolymer; and b) a curative agent comprising i) a polyol; ii) an aromatic diamine; iii) a thixotropic aliphatic amine; and iv) a thixotropic colloidal additive, wherein the prepolymer comprises a product produce by the reaction of a polyol with an organic diisocyanate monomer comprising 4,4?-diisocyanato diphenylmethane (MDI), and which prepolymer comprises less than 1.0% by weight of free MDI monomer, based on the toal weight of the prepolymer, exhibits a range of enhanced physical properties compared to those obtained from prepolymers comprising a higher level of free MDI monomer.

Abstract: A method and compositions are described which improve extrusion- and creep-resistance of components for use in a high temperature applications including sealing elements and seal connectors among others. The method includes providing a composition having an aromatic polymer and a crosslinking compound, and subjecting the composition to a heat molding process to form the component and crosslink the aromatic polymer.

Abstract: The invention relates to a process for the preparation of a particulate polyethylene product in a loop reactor, wherein the polymerization catalyst applied in the polymerization process comprises a particulate metallocene-alumoxane catalyst immobilized on a porous silica support; and whereby said metallocene-alumoxane catalyst is heterogeneously distributed on said porous silica support.

Abstract: A catalyst composition comprising (i) a metal salt complex of an imine bis(phenol) compound characterized by Structure 1: Wherein O and N represent oxygen and nitrogen respectively; R comprises a halogen, a hydrocarbyl group, or a substituted hydrocarbyl group; R2 and R3 can each independently be hydrogen, a halogen, a hydrocarbyl group, or a substituted hydrocarbyl group; and Q is a donor group; and (ii) a metallocene complex.

Abstract: This invention relates method to prepare and compositions pertaining to an amorphous polymer comprising: at least 95 mol % propylene and 0 to 5 mol % vinyl monomer content, wherein the polymer has a g?vis of less than 0.95, an Mn of about 200 to about 10,000, an ?Hf of less than 10 J/g and has greater than 50% allylic chain end functionality.

Abstract: The present invention relates to pre-catalysts for olefin metathesis and composition involving these pre-catalysts.

Abstract: A polymer reactor-blend comprising at least a first component having a polydispersity index of greater than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer and a second component having a polydispersity index of less than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer wherein a molecular weight distribution of the second component lies within a molecular weight distribution of the first component.

Abstract: A water-soluble copolymer comprising, by mass relative to the total mass of the copolymer: 1 to 40% of at least one cationic monomer; 59.99 to 98% of at least one nonionic monomer; 0.01 to 10% of at least one monomer of formula (I); in which: R1 is a hydrogen atom or a methyl radical; Z is a divalent group —C(?O)—O—, or —(?O)—NH—; n is an integer between 2 and 200; R2 is a hydrogen atom or a carbon-containing radical which is saturated or unsaturated, optionally aromatic, linear, branched or cyclic, comprising 1 to 30 carbon atoms, and from 0 to 4 heteroatoms chosen from the group comprising O, N and S; the copolymer having a cationic charge density between 0.05 and 3 meq/g.

Abstract: Low molecular weight polymers useful in aggregating mineral components in aqueous mineral slurries to release and separate individual components of the slurry, which may then be recovered from the slurry.

Abstract: A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to form a gum, gel, rubber, or resin.

Abstract: The present invention provides an epoxy resin molded article excellent in thermal conductivity and an epoxy composition suitable for forming such an epoxy resin molded article. Namely, the present invention relates to an epoxy composition containing an epoxy monomer having a mesogenic skeleton and a phenolic curing agent having a triphenyl methane structure.

Abstract: The present invention relates to a preparation method of a polylactide resin, in which the preparation method includes the step of performing ring opening polymerization of lactide monomers in the presence of an organometallic catalyst and an aromatic monomer scavenger, and the aromatic monomer scavenger is used in an amount of 0.1 to 20 parts by weight, based on 100 parts by weight of the lactide monomers.

Abstract: A process for making a shaped part from a polymer selected from polyethylene terephthalate (PET) and polyethylene terephthalate (PET) and polyethylene naphthalate (PEN) by using a compacting tool comprising a die having a cavity and a punch having an outer surface. The process comprises the steps of: a) placing particles of the polymer in the cavity of the die heated to a compaction temperature, wherein the polymer has an intrinsic viscosity of at least 0.45 dL/g and the particles have an average particle size of 0.5-4000 ?m, b) pressing the particles in the die cavity at a pressure of at least 3 MPa for 5-15 minutes while maintaining the temperature of the die at the compaction temperature and c) removing the shaped part from the die cavity. When the polymer is PET, the compaction temperature is 235-259° C. When the polymer is PEN, the compaction temperature is 250-275° C.

Abstract: To provide a method for producing a polymer, which contains: bringing an intermediate polymer, which has been obtained through ring-opening polymerization of a ring-opening polymerizable monomer, into contact with, and melting the intermediate polymer in a compressive fluid having a density of 230 kg/m3 or greater, at temperature lower than a melting point of the intermediate polymer, at a ratio of 0.05 to 10, to dissolve a low-molecular-weight compound contained in the intermediate polymer in the compressive fluid, to thereby extract the low-molecular-weight compound, wherein the ratio is a ratio of a mass of the intermediate polymer to a mass of the compressive fluid.

Abstract: An epoxy-functional resin composition including the reaction product of (a) a stoichiometric excess of at least one divinylarene dioxide, and (b) at least one of: a primary (1°) monoamine, a bis-secondary (2°) amine lacking nitrogen atoms, or mixtures thereof; a curable composition including (i) the epoxy-functional resin composition, and (ii) at least one curing agent; and a cured thermoset resin prepared from the curable composition.

Abstract: Disclosed herein are novel and improved preparations and methods for manufacturing substantially liquid preparations of recombinant human insulin API. The purified recombinant human insulin Active Pharmaceutical Ingredient (API) preparations are substantially free of by-products associated with the lyophilization and/or crystallization. The methods for manufacturing the substantially liquid recombinant human insulin API preparations are provided with optional steps for subjecting the recombinant insulin preparation to lyophilization and/or crystallization. Enhanced yield of recombinant insulin of greater purity are thereby provided according to the present invention. Highly purified formulations of recombinant human insulin of the API insulin preparations disclosed herein are also provided. Stably transformed E.

Abstract: The present invention is directed to a modified synthesis cassette (110) that enables flexible, in-process monitoring of radiopharmaceutical synthesis. Also provided is a method for radiopharmaceutical synthesis using the modified synthesis cassette (110).

Abstract: Novel methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) or glycosylamine under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product containing an aziridinyl ring. Optional subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product. Coupling of a peptide thioacid and glycosylamine yields a glycosylated peptide.

Abstract: A process for extraction of a peptide from a reaction mixture resulting from a peptide coupling reaction, the reaction mixture containing the peptide and a polar aprotic solvent selected from the group consisting of N,N-dimethylformamide, N,N-dimethylacetamide and N-methyl-2-pyrrolidone, whereby the process includes a step a) and a step b): step a) including the addition of a component a1) and a component a2), whereby component a1) is 2-methyltetrahydrofuran and component a2) is water, to the reaction mixture, so that a biphasic system with an organic layer and an aqueous layer is obtained; step b) including the subsequent separation of the organic layer containing the peptide from the aqueous layer. In an embodiment, a combination of 2-methyltetrahydrofuran and an organic solvent 1 selected from the group consisting of n-heptane, toluene, ethylacetate, isopropylacetate, acetonitrile and tetrahydrofuran is used for the process for extraction.

Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.

Abstract: The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide (—CONHR)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.

Abstract: A casein hydrolysate formed by controlled hydrolysis of a casein substrate by an aspergillus-derived (fugal) proteolytic preparation is described. The controlled hydrolysis employs a FlavorPro-Whey™ formulation and a degree of hydrolysis (% DH) of from 5% DH to 15% DH. The hydrolysate has at least a 98% reduction in antigenicity compared to intact sodium caseinate and a mean bitterness score of less than 30%.

Abstract: The present invention refers to a strain of Lactobacillus curvatus bacteria deposited in the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmBH (DSMZ) under thew accession number DSM 18775, as well as to compositions, cultures and food products comprising thereof. The strain of the invention is useful for preserving food products, especially under refrigerated conditions.

Abstract: Nanocellulose foams containing at least one active ingredient and methods of preparing such nanocellulose foams containing one or more active ingredients are provided herein. In some embodiments, a method for preparing nanocellulose foam containing active ingredients may include forming a liquid mixture of nanocellulose, wherein the nanocellulose is at least one of dispersed, suspended or gelled in the liquid mixture; drying the liquid mixture of nanocellulose to form a nanocellulose foam; and mixing at least one active ingredient into at least one of the liquid mixture of nanocellulose or the nanocellulose foam. In some embodiments, a nanocellulose structure may include a nanocellulose foam comprising at least one of a carboxylate group, a hydroxyl group, or a sulfate group bonded to an active ingredient. In some embodiments, the nanocellulose structures are enhanced or crosslinked with metal cations.

Abstract: A tissue scaffold that made of albumin having continuous solid network and void are disclosed. Methods for preparing albumin tissue scaffolds from animal albumins are also disclosed.

Abstract: The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzipine. The invention also relates to conjugates of an olanzipine hapten and a protein.

Abstract: The invention relates to compounds of Formula I, wherein L1, L2, and L3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract: The present invention relates to a fusion protein resulting from the fusion of a cancer-specific antibody and an angiogenesis inhibitor, and relates to an anti-cancer composition including the same. More specifically, in the present invention, it is preferable that the cancer-specific antibody is trastuzumab or a fragment thereof, and the angiogenesis inhibitor is a VEGF-Trap. When the fusion protein according to the present invention is used, there are advantages in that angiogenesis and cancer cell growth can be effectively inhibited as compared to trastuzumab or VEGF-Trap, and side effects can also be reduced.

Abstract: The present invention relates to improved methods for antibody engineering, e.g., humanization. In particular, the disclosure provides a high-throughput antibody humanization process that can be automated by computer-implementation.

Abstract: Engineered multi-specific binding proteins that bind to one or more target proteins (e.g., antigens) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.

Abstract: Engineered cross-over DVD-Ig binding proteins that bind to two or more target proteins (e.g., antigens) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.

Abstract: Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Abstract: Suggested is a process for obtaining immunoglobulins, wherein (a) colostral milk from days 0 to 7 is subjected to thermal treatment, skimming the cream, (b) the skimmed milk such obtained is subjected to sterile microfiltration thus producing a first retentate R1 which contains the casein, and a first permeate P1, (c) the first permeate P1 is subjected to ultrafiltration thus producing a second permeate P2 which contains lactose and minerals, and a second retentate R2, in which the immunoglobulins are concentrated.

Abstract: The disclosure relates to a magnetic particle comprising: a ligand that specifically binds an intracellular antigen, a cell membrane penetrating cationic peptide and a peptide comprising an amino acid sequence that is adapted to interact with the secretory pathway in a cell and the use of the particle in selection of cells from heterogeneous cell populations.