Patents Issued in August 7, 2014
  • Publication number: 20140220125
    Abstract: The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: July 12, 2012
    Publication date: August 7, 2014
    Applicant: NOVARTIS AG
    Inventors: Wolfgang Marterer, Mahavir Prashad, Edwin Bernard Villhauer, Liladhar Murlidhar Waykole, James Anthony Vivelo, Bertrand Sutter, Jean-Claude Bianchi, Raeann Wu, Denis Har, Piotr H. Karpinski, Massimo Pignone, Doris Stingelin, Eckart Buerger
  • Publication number: 20140220126
    Abstract: The present disclosure relates to pharmaceutical compositions that are abuse resistant and may also provide controlled release. The present disclosure also relates to the use of pharmaceutical compositions in the treatment of pain.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: EGALET LTD.
    Inventors: Peter Holm Tygesen, Karsten Lindhardt, Martin Rex Olsen, Gina Engslev Fischer, Jan Martin Overgard, Georg Boye, Nikolaj Skak, Torben Elhauge
  • Publication number: 20140220127
    Abstract: The present invention relates to the use of a sustained release matrix containing at least one opioid for producing a solid oral formulation in table form suitable for reducing blood concentration fluctuations of said opioid.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Applicant: ETHYPHARM
    Inventors: Catherine HERRY, Maryline BOYER, Francoise VAUZELLE-KERVROEDAN, Pascal OURY
  • Publication number: 20140220128
    Abstract: A solid dosage form comprises coated particles of bisphosphonate or a pharmaceutically acceptable analogue or derivative thereof.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 7, 2014
    Applicant: Arrow International Limited
    Inventors: Peter Persicaner, Judy Craig
  • Publication number: 20140220129
    Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Applicant: Methylation Sciences International SRL
    Inventors: Dechi GUAN, I. David MACDONALD
  • Publication number: 20140220130
    Abstract: The present invention relates to a matrix material comprising a pharmaceutical composition such as a matrix material with a pharmaceutical composition printed on the surface. In one embodiment the pharmaceutical composition comprises thrombin. The invention further describes a method for making the matrix material with a pharmaceutical composition printed on the surface. In one specific embodiment the invention also relates to the use of said matrix material for promotion of hemostasis and/or wound healing. The invention also relates to a kit-of-parts comprising a matrix with a pharmaceutical composition and a container with a peelable lid.
    Type: Application
    Filed: December 20, 2013
    Publication date: August 7, 2014
    Applicant: Ferrosan Medical Devices A/S
    Inventors: Kristian Larsen, Mads Sabra
  • Publication number: 20140220131
    Abstract: The present invention is directed to a personal care composition comprising: a personal care composition comprising a particle complex consisting of a hydrolyzed corn starch, a starch/cellulose polymer, a hydrogenated phospholipid, and gum arabic; and an aqueous carrier. The personal care composition is suitable for delivery as a sprayable composition which provides volumizing, hair fixing, and conditioning as a leave-on treatment. The present invention is also directed to a method for forming a particle complex wherein the complex provides volumizing, hair fixing, and conditioning benefits when applied to hair.
    Type: Application
    Filed: February 5, 2013
    Publication date: August 7, 2014
    Inventors: John Michael Bohen, Amy Christine Anderson-Gaber, Anita Marie Grahn
  • Publication number: 20140220132
    Abstract: The current invention pertains to pharmaceutical formulation including at least one jasmonate compound of the jasmonate family of compounds combined with a carrier, such as inclusion compounds, particularly those able to form nano or micro encapsulation systems. The invention generally refers to inclusion complexes which includes jasmonate compounds.
    Type: Application
    Filed: February 27, 2012
    Publication date: August 7, 2014
    Inventor: José E. Fehr Pereira Lopes
  • Publication number: 20140220133
    Abstract: A composition and methods to bind and remove toxic agents from a subject exposed to the toxic agents are described herein. The composition comprises a stealth agent and scavenging agent bound to a nanoparticle platform. The stealth agent prevents the nanomedicine from detection and elimination by the immune system allowing the scavenging agent to bind the target toxic agent. The stealth agent comprises an exposing group that once removed from the stealth agent allows the nanomedicine and bound toxic agent to be detected and eliminated from the subject's body.
    Type: Application
    Filed: November 27, 2013
    Publication date: August 7, 2014
    Inventors: Giulio F. Paciotti, Lawrence Tamarkin
  • Publication number: 20140220134
    Abstract: The disclosure provides methods for treating diabetes, treating overweight, treating obesity, reducing body weight, treating cardiovascular diseases, treating fatty liver diseases, treating gastrointestinal diseases, and treating neurodegenerative diseases through the once monthly administration of pharmaceutical formulations containing a non-aqueous carrier and GLP-1 receptor agonists that provides therapeutically effective plasma concentration levels of the GLP-1 receptor agonists over the course of a month.
    Type: Application
    Filed: June 21, 2012
    Publication date: August 7, 2014
    Applicants: Astrazeneca Pharamceuticals LP, Amylin Pharmaceuticals LLC
    Inventors: Matthew L. Zierhut, Brenda B. Cirincione
  • Publication number: 20140220135
    Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein an active agent and a permeation enhancer are bound to or associated with the nanoparticles.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Inventors: Thomas Rademacher, Phillip Williams
  • Publication number: 20140220136
    Abstract: The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“TA”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation. Next, the formulation along with fibrinogen and thrombin is applied to a wound site where an outer surface of the polymer microsphere degrades in a proteolytic environment to expose and release the incorporated protease inhibitor to the surrounding hydrogel or sealant or clot matrix at the wound site.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Inventors: Binoy K. Bordoloi, Nayan Jyoti Sarma, Rodney L. Eisenberg
  • Publication number: 20140220137
    Abstract: Synergistic composition able to rapidly and efficiently terminate Rhynchophorus ferrugineus infestation, in palms or other species suffering from this parasite. The composition comprises one or more among permethrin, cypermethrin, lambda-cyhalothrin; one or more among chlorpyrifos methyl, and chlorpyrifos ethyl; furthermore, benzisothiazolin-3-one, piperonyl butoxide, imidacloprid. The parasite dies shortly after contact with the product, infestation is terminated, and the palm remains protected against new attacks for a long time; the product is not toxic to the palm, on the contrary the plant recovers a level of health even higher than the initial one.
    Type: Application
    Filed: August 14, 2012
    Publication date: August 7, 2014
    Applicant: Romano Natur GmbH
    Inventor: Giuseppe Romano
  • Publication number: 20140220138
    Abstract: Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Adam Friedman, Joel Friedman, Joshua Nosanchuk, Parimala Nacharaju, Karin Blecher, Chaim Tuckman-Vernon
  • Publication number: 20140220139
    Abstract: The present invention provides a ceramide lamella structure comprising a glucoside surfactant, a preparation method thereof, and a skin composition for external use containing the same. According to the skin preparation composition for external use of the present invention, phase stability is very excellent and a greater amount of ceramides can be stably formed according to the stability of ceramides using multilayered lamellar liquid crystals, thereby showing excellent skin moisturizing and skin barrier function repairing effects when applied to the skin.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 7, 2014
    Applicant: AMOREPACIFIC CORPORATION
    Inventors: Seung Han Park, Byung Guen Chae, Sang Hoon Han
  • Publication number: 20140220140
    Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 7, 2014
    Applicant: THE UNIVERSITY OF LIVERPOOL
    Inventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
  • Publication number: 20140220141
    Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 7, 2014
    Applicant: THE UNIVERSITY OF LIVERPOOL
    Inventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
  • Publication number: 20140220142
    Abstract: The present invention provides a composition for bone regeneration comprising: particulate demineralized bone matrix; fibrous demineralized bone matrix; and a hydrate. In addition, it is preferable that the present invention comprises a demineralized solution-derived isolated product obtained by neutralizing a demineralized solution, separated from a demineralization process, and separating the precipitate generated.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 7, 2014
    Applicant: CG BIO CO., LTD.
    Inventors: Seok-Beom Song, Soo-Yong Kim, Jung-Won So, Han-Sol Seo, Hyun-Seung Ryu, Giue-Nam Kim, Byoung-Suck Kim
  • Publication number: 20140220143
    Abstract: Provides is a therapeutic technology that combines the phototoxic and immune-stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform. For example, zinc pthalocyanine, which is a long-wavelength absorbing photosensitizer, integrated into a polymeric nanoparticle core made up of poly(D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). The outside surface of the core can be coated with metallic nanoparticles, which are then modified with CpG-ODN. Metastatic mouse breast carcinoma cells showed significant photocytotoxicity of the hybrid after irradiation with a 660 nm LASER light and this activity was remarkably better than either treatment alone.
    Type: Application
    Filed: July 11, 2012
    Publication date: August 7, 2014
    Inventors: Shanta Dhar, Joshua Choi, Sean Marache
  • Publication number: 20140220144
    Abstract: The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 7, 2014
    Applicant: Aptalis Pharmatech, Inc.
    Inventors: Gopi M. Venkatesh, Nehal H. Vyas, Michael Gosselin, Jin-Wang Lai
  • Publication number: 20140220145
    Abstract: An improved method for stimulating electrical activity in an eye is provided. Provided is a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Applicant: The Regents of the University of Colorado, a Body Corporate
    Inventors: Jeffrey Olson, Naresh Mandava
  • Publication number: 20140220146
    Abstract: The invention pertains to the use of opiod antagonists for the treatment of urinary retention.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: Euro-Celtique S.A.
    Inventors: Michael HOPP, Petra LEYENDECKER
  • Publication number: 20140220147
    Abstract: The invention relates to a pharmaceutical composition comprising factor VII encapsulated in micelles formed from block copolymer molecules containing (i) a hydrophilic polymer segment consisting of a polyalkylene glycol and (ii) a hydrophobic polymer segment consisting of a polyamino acid, with said polyamino acid comprising exclusively amino acid residues selected from the group consisting of histidine, lysine, aspartic acid and glutamic acid residues, wherein a part of said amino acid residues is substituted with a hydrophobic group.
    Type: Application
    Filed: July 31, 2012
    Publication date: August 7, 2014
    Applicants: NANOCARRIER, LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
    Inventors: Florence Arvis, Sylvain Huille, Mitsunori Harada
  • Publication number: 20140220148
    Abstract: The present invention relates to pharmaceutical compositions, food supplement compositions and cosmetic compositions comprising diaminooxidase, and to the use thereof.
    Type: Application
    Filed: April 4, 2014
    Publication date: August 7, 2014
    Applicant: SCIOTEC DIAGNOSTIC TECHNOLOGIES GMBH
    Inventors: Albert MISSBICHLER, Franz GABOR, Herwig REICHL
  • Publication number: 20140220149
    Abstract: A method for treating or preventing disorders, diseases, and symptom of reflux, that is laryngopharyngeal reflux (LPR), in the laryngopharynx caused by pepsin comprises orally administering to the laryngopharynx of a patient an effective amount of cellulose powder. A method for treating or preventing damage to the lining membranes of at least some of the aerodigestive tract, the damage caused by pepsin, comprises coating at least some of the lining membranes with an effective amount of a cellulose powder. Upon inhalation of the powder, the powder coats the lining membranes. Upon coating the lining membranes, the powder becomes a gel. The gel prevents the pepsin from binding with the lining membranes, thereby preventing damage caused by pepsin in laryngopharyngeal reflux or in extra-esophageal reflux.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Inventors: Jamie KOUFMAN, Michael JAMES, Peter JOSLING
  • Publication number: 20140220150
    Abstract: The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and their mixtures, to provide an armamentarium of defenses from multiple stressors in order to help bees survive and more particularly overcome a complex of symptoms collectively called colony collapse disorder (CCD). The methods and compositions of this designed fungal bioshield helps tilt the balance in favor of bee colony survival, improving the health conditions, disease resistance, pesticide tolerance, pollution tolerance, drought tolerance, pollination abilities, and quality of the honey produced by bees.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Inventor: Paul Edward Stamets
  • Publication number: 20140220151
    Abstract: The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and/or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition.
    Type: Application
    Filed: June 20, 2013
    Publication date: August 7, 2014
    Inventors: Alan M. Goldberg, Steven Dills, William Mark, Bruce Sutton, Chad Byerley
  • Publication number: 20140220152
    Abstract: Disclosed herein is a non-human animal model of protein aggregation cardiomyopathy. Also disclosed are compositions and methods of treating or preventing a condition in a subject caused or exacerbated by reductive stress. Also disclosed are compositions and methods of predicting, detecting, or monitoring reductive stress in a subject.
    Type: Application
    Filed: September 12, 2013
    Publication date: August 7, 2014
    Applicant: University of Utah Research Foundation
    Inventors: Ivor J. Benjamin, Namakal S. Rajasekaran, Thomas P. Kennedy
  • Publication number: 20140220153
    Abstract: The invention is generally directed to antimicrobial composition comprising a matrix material and both of silver and zinc distributed there through, wherein the matrix material comprises at least one of Si02, Ti02, Zr02, AI203, or Zeolite, and the uses of such compositions as anti-bacterial and acaricidal. The invention is also generally directed to antimicrobial composition comprising a matrix material arid both of silver and a metal selected from the group of noble or transition metals distributed there through, wherein the matrix material comprises at least one of Si02, Ti02, Zr02, AI203, or Zeolite, and the uses of such compositions as antibacterial and acaricidal.
    Type: Application
    Filed: September 6, 2012
    Publication date: August 7, 2014
    Applicant: Nanox Tecnologia S/A
    Inventors: Luiz Gustavo Pagotto Simões, Andre Luiz De Araújo, Daniel Tamassia Minozzi
  • Publication number: 20140220154
    Abstract: What is described is a method of preventing or treating heterotopic ossification, vascular calcification, and pathologic mineralization, comprising administering an drug, wherein the drug is an antagonist of the Hedgehog (Hh) pathway. For example the antagonist consists of arsenic trioxide, sodium arsenite, phenylarsine, GANT-58, GANT-61, zerumbone vismodegib (GDC-0449, Genentech), bevacizumab, gemcitabine, nab-paclitaxel, FOLFIR, FOLFOX, RO4929097, cixutumumab, cisplatin, etoposide, LDAC, decitabine, daunorubicin, cytarabin, rosiglitazone, goserelin, leuprolide, capecitabine, fluorouracil, leucovorin, oxaliplatin, irinotecan, diclofenac, BMS-833923 (XL139), IPI-926—Infinity Pharmaceuticals, Inc., LDE225, LEQ506—Novartis Pharmaceuticals, TAK-441 Millennium Pharmaceuticals, Inc., and PF-04449913—Pfizer, alone or in combination therapy.
    Type: Application
    Filed: June 28, 2012
    Publication date: August 7, 2014
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Service
    Inventors: Jean Regard, Yingzi Yang
  • Publication number: 20140220155
    Abstract: A method of stimulating elastin and/or collagen production in the tissues of the vagina, comprising the steps of providing a composition including at least one of a water soluble zinc salt such as zinc sulfate and a peroxisome proliferator-activated receptor beta/delta (PPAR 13/8) agonist, and administering the composition to the tissue of the vagina. Compositions for stimulating 5 elastin and/or collagen production in the tissues of the vagina are also disclosed.
    Type: Application
    Filed: July 10, 2012
    Publication date: August 7, 2014
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Peter Takacs, Keith A. Candiotti, Carlos A. Medina
  • Publication number: 20140220156
    Abstract: The present invention relates to ionic compositions for promoting mucosal reciliation, particularly in the sinonasal cavity. The ionic components of the composition can include potassium, calcium, rubidium, zinc, bromide, and magnesium in an isotonic solution. In other embodiments, the ionic components of the composition can include magnesium, bromide, sulfate, sodium, and chloride.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Applicant: Red Oax Holdings, LLC
    Inventor: Kevin Powers
  • Publication number: 20140220157
    Abstract: The present invention relates to ionic compositions for debriding a tissue, particularly in the sinonasal cavity. The ionic components of the composition can include potassium, calcium, rubidium, zinc, bromide, and magnesium in an isotonic solution. In other embodiments, the ionic components of the composition can include magnesium, bromide, sulfate, sodium, and chloride.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Applicant: RED OAX HOLDINGS, LLC
    Inventor: Kevin Powers
  • Publication number: 20140220158
    Abstract: This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin affected by intrinsic aging and/or photo-induced aging comprising topically applying a topical formulation to the skin, wherein said topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, ?-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Applicant: AD LUNAM LABS INC.
    Inventors: William H. Beeson, Alvin T. Rockhill
  • Publication number: 20140220159
    Abstract: The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
    Type: Application
    Filed: January 21, 2014
    Publication date: August 7, 2014
    Inventors: Paramjit S. ARORA, Quintin PAN, Anna MAPP
  • Publication number: 20140220160
    Abstract: Methods and products for detecting in vitro the presence of damage on DNA or the presence of a biological response to damage on DNA at the molecular level. Molecular Combing or other nucleic acid stretching methods are employed together with compounds reacting with DNA, probes binding DNA, or nucleic acid monomers, especially labeled nucleic acid monomers.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Applicant: GENOMIC VISION
    Inventors: Lucia CINQUE, Aaron Bensimon
  • Publication number: 20140220161
    Abstract: The present invention provides methods of stimulating angiogenesis and the growth or migration of cells associated with angiogenesis, by contacting animals, tissues, or cells with sulfide, alone or in combination with nitric oxide. These methods may be used for a variety of purposes, including promoting wound healing, increasing blood flow, and for the treatment and prevention of diseases and disorders associated with decreased blood flow, including ischemic or hypoxic injury.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventor: Csaba Szabo
  • Publication number: 20140220162
    Abstract: The invention relates to a preparation containing several amino acids and plant extracts and its alcohol detoxification activity. The component (a) in the preparation contains a mixture of two or more amino acids or derivatives thereof; the component (b) in the preparation contains a mixture of three or more extracts from plants. There are several plant extracts used in this invention such as the extract of ginseng radix, the extract of ginkgo biloba leaf, the extract of Silibinin, the extract of barbury wolfberry fruit and tea polyphenols. The invention also relates to the biological activities of said preparation, such as the liver protection from chemical injury, the tolerance enhancement of hypoxy and the rapid decrease till elimination of the blood alcohol content.
    Type: Application
    Filed: April 4, 2014
    Publication date: August 7, 2014
    Applicants: Hangzhou Adamerck Pharmlabs Inc., Modutech S.A.
    Inventors: Youmao QI, Qing JIE, Fengmin ZHANG, Ying GU, Meiping YU
  • Publication number: 20140220163
    Abstract: The embodiments herein provide a powdered composition of natural substances for controlling deficiencies in polypeptide alpha and beta hemoglobin chains and a diet plan for treating thalassemia patient. The composition comprises passargad powder, pars powder, purgative material, fumigation material, snuffing material, vinegar syrup and parsomash powder. The passargad powder is a stomach tonic and acts as anti-parasitic, anti-diarrheal, anti-dysentery, anti-bloating and anti-heartburn agents. The pars powder comprises sprouted grains for providing nutrition to cells. The purgative material is body purifier or detoxification agent and helps in motion and bowl movement. The vapor/fumigation material softens and reduces stickiness of sputum and removes sputum. The snuff helps in sneezing and removal of sputum. The vinegar syrup breaks down fat and removes toxins. The parsomash is an detoxification agent.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Inventor: Hamzeh Soleimani Babadi
  • Publication number: 20140220164
    Abstract: Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent or an alkyl alcohol solvent. Methods of making and using the compositions are disclosed.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: 0903608 B.C. Ltd.
    Inventors: Karan MANHAS, Annett ROZEK
  • Publication number: 20140220165
    Abstract: The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use.
    Type: Application
    Filed: September 13, 2012
    Publication date: August 7, 2014
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • Publication number: 20140220166
    Abstract: Pharmaceutical compositions containing an extract of Houttuynia cordata (THUNB) as an active ingredient for preventing and treating dementia, Parkinson's disease, or epilepsy and methods for using the same. Since the extract of Houttuynia cordata or the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino has a cell protection effect and/or a cognition function improved effect in various models including an Amyloid-? induced dementia model, a scopolamine induced dementia model, a 6-hydroxydopamine (6-OHDA) induced Parkinson's disease model, and a Kainic acid induced epilepsy model, the extract of Houttuynia cordata or the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino may be used as the pharmaceutical composition for preventing and treating dementia, Parkinson's disease, or epilepsy and in health foods for preventing and treating dementia, Parkinson's disease, or epilepsy.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: UNIVERSITY INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Myung Sook Oh, Hyo Geun Kim, Hanbyeol Park
  • Publication number: 20140220167
    Abstract: The present invention relates to a mold for a multi-layer container. The mold includes a cold-half portion containing a cavity, and a hot-half portion containing a first resin flow path for connecting an interior of a first injection cylinder to the cavity, a second resin flow path for connecting an interior of a second injection cylinder to the cavity, and a junction portion of the first resin flow path and the second resin flow path. The junction portion in the hot-half portion is positioned upstream of a gate portion opened to the cavity included in the cold-half portion, the second resin flow path contains an inhibitor for partially inhibiting a resin flow.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventor: Jun MITADERA
  • Publication number: 20140220168
    Abstract: Three-dimensional printing system with automated part removal. In one embodiment, the system includes a printing surface on which a part is made and a printing device supported for controlled movement with respect to the printing surface to print the part on the printing surface. A blade is supported for motion across the printing surface to release the part from the printing surface. The present printing system according to the invention requires fewer user steps than known in the prior art.
    Type: Application
    Filed: January 16, 2014
    Publication date: August 7, 2014
    Inventors: Alfonso Alexander Perez, Christopher Michael Haid, Forrest W. Pieper, Mateo Pena Doll
  • Publication number: 20140220169
    Abstract: An apparatus for cutting and de-molding a dough sheet is described. The apparatus comprises a hollow cutter body, a cutting edge about an opening in the hollow cutter body, a compressible extractor in the hollow cuter body, an ejector, and a stamp with a pattern. The compressible extractor may be actuated between a first and second state. The hollow cutter body is magnetically engaged with the compressible extractor and the compressible extractor is magnetically engaged with the stamp.
    Type: Application
    Filed: February 5, 2013
    Publication date: August 7, 2014
    Applicant: Mastrad, S.A.
    Inventors: MATHIEU LION, Marie Buet
  • Publication number: 20140220170
    Abstract: A device for making patties of compressible food matter of different sizes, for example meat patties, comprises a first member having a first compression plate for making a patty of a corresponding size and shape. The device further comprises a second member to be added onto the first member. The second member has a second compression plate to extend from the first compression plate to form therewith a larger compression plate when the first member is mounted onto the second member, in order to make a food patty of a corresponding larger size. The first and second members have respective cooperating attaching means to connect the members in an assembled position.
    Type: Application
    Filed: February 1, 2013
    Publication date: August 7, 2014
    Applicant: LES PROMOTIONS ATLANTIQUES INC / ATLANTIC PROMOTIONS INC.
    Inventor: Nicolas BOURBEAU
  • Publication number: 20140220171
    Abstract: A pressure differential can be applied across a mold sheet and a semiconductor (e.g. silicon) wafer (e.g. for solar cell) is formed thereon. Relaxation of the pressure differential can allow release of the wafer. The mold sheet may be cooler than the melt. Heat is extracted through the thickness of the forming wafer. The temperature of the solidifying body is substantially uniform across its width, resulting in low stresses and dislocation density and higher crystallographic quality. The mold sheet can allow flow of gas through it. The melt can be introduced to the sheet by: full area contact with the top of a melt; traversing a partial area contact of melt with the mold sheet, whether horizontal or vertical, or in between; and by dipping the mold into a melt. The grain size can be controlled by many means.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Applicant: 1366 TECHNOLOGIES, INC.
    Inventors: Emanuel M. Sachs, Richard L. Wallace, Eerik T. Hantsoo, Adam M. Lorenz, G.D. Stephen Hudelson, Ralf Jonczyk
  • Publication number: 20140220172
    Abstract: A vibration drive assembly comprising two rotary servo motors and an electronic motor controller electrically coupled to the servo motors and configured to regulate the motors and operate them in synchronism with one another at a predetermined rotational speed. Two articulated drive trains are connectable between the servo motors and mold assembly vibrator shafts of a concrete product molding machine and are configured to mechanically transmit rotational motion from the servo motors to the vibrator shafts when the mold assembly is in an elevated vibration position with the vibrator shaft axes coaxially aligned with rotational servo motor axes. The drive trains remain connected between the servo motors and vibrator shafts when the mold assembly is in a rest position below the vibration position, with the vibrator shaft axes axially mis-aligned with respect to the servo motor axes.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 7, 2014
    Inventor: Douglas Krentz
  • Publication number: 20140220173
    Abstract: A microfluidic device platform may include a valve manifold adapted to deliver a programmable pressure to a plurality of ports, a cell chamber having programmable environmental control, and a chip-to-world interface.
    Type: Application
    Filed: September 4, 2012
    Publication date: August 7, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Carlo Joseph Quinonez
  • Publication number: 20140220174
    Abstract: A sterilized food product containing starch, the starch having: (a) an amylose content of at least 60 wt. %; (b) a median particle size of between 1 and 15 ?m, at least 90 wt. % of the starch particles having a particle diameter of less than 50 ?m; and (c) a non-digestible starch content of less than 50 wt. %. The product is obtained by heating and rapidly cooling the starch product and has a high slowly digestible starch content. It is suitable for use in the treatment of diabetes, obesity, insulin resistance, or for postprandial glucose response.
    Type: Application
    Filed: January 7, 2014
    Publication date: August 7, 2014
    Applicant: N.V. Nutricia
    Inventors: Evan ABRAHAMSE, Wynette Hermina Agnes KIERS, Houkje BOURITIUS, Koenraad Gerard Christoffel WEEL