Patents Issued in August 28, 2014
  • ADSORBENTS FOR ORAL ADMINISTRATION
    Publication number: 20140242147
    Abstract: The present invention aims to provide an adsorbent for oral administration comprising ACF that has high adsorption or removal performance by adsorbing or removing toxic substances in the living body greatly and rapidly. The present invention is an adsorbent for oral administration comprising activated carbon fibers for treating or preventing kidney diseases or dialysis complications.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 28, 2014
    Applicant: TEIJIN PHARMA LIMITED
    Inventors: Yasumi Nishiwaki, Takashi Murakami, Nobuaki Eto, Keiichiro Imaizumi, Akihito Ohtaki, Kenji Shimazaki
  • ANTIMICROBIAL MATERIALS AND METHODS
    Publication number: 20140242148
    Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
    Type: Application
    Filed: August 3, 2012
    Publication date: August 28, 2014
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: David G. Whitten, Kirk S. Schanze, Eunkyung Ji, Dimitri Dascier, Anand Parthasarathy, Thomas S. Corbitt, Kirsten Cicotte, Elizabeth LeBleu Dirk, Xuzhi Zhu
  • High-Viscosity Silicone Adhesive
    Publication number: 20140242149
    Abstract: Provided in various embodiments are high viscosity, shear-thinning silicone compositions that can be pattern coated directly onto a substrate and silicone compositions having high-density particles suspended in an adhesive gel. The silicone compositions contain a thixotropic additive, such as a hydrogenated vegetable oil. The silicone compositions may be applied on a substrate for use in medical devices or wound dressings.
    Type: Application
    Filed: October 12, 2012
    Publication date: August 28, 2014
    Applicant: Dow Corning Corporation
    Inventors: David Gantner, Roger A. Gibas, Do-Lung Pan, Xavier Thomas, Christine A. Weber
  • THERAPEUTIC COMPOSITIONS AND METHODS OF TREATMENT WITH CAPSIANOSIDE-TYPE COMPOUNDS
    Publication number: 20140242150
    Abstract: The present invention discloses the use of certain compounds as therapeutic agents, and in particular as analgesics and anti-inflammatory agents. Such compounds include, for example, certain diterpene monoglycosides and diterpene diglycosides. The compounds of the present invention may be synthesized or isolated from the fruit of the genus Capsicum, and in particular may be isolated from sweet bell peppers (C. annuum). Pharmaceutically-acceptable salts, enantiomers, diasteriomers, racemic mixtures, enantomerically-enriched mixtures, solvates, and prodrug s of such compounds are also disclosed. Pharmaceutical compositions and methods of using such compounds, including pharmaceutical compositions and methods of using such compounds in combination with one or more active ingredients, are also disclosed.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: BMB PATENT HOLDING CORPORATION
    Inventor: Barry Miles Belgorod
  • ADHESIVE SKIN PATCH
    Publication number: 20140242151
    Abstract: The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: Sekisui Chemical Co., Ltd.
    Inventors: Hiroko UDAGAWA, Toshikazu KOMODA, Masaru HAMABE
  • IMMUNOGENIC COMPOSITIONS AND USES THEREOF
    Publication number: 20140242152
    Abstract: This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Inventors: Andrew Geall, Gillis Otten, Susan Barnett
  • NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE
    Publication number: 20140242153
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 28, 2014
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Compounds, Compositions, Methods, and Kits Relating to Telomere Extension
    Publication number: 20140242154
    Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.
    Type: Application
    Filed: February 22, 2014
    Publication date: August 28, 2014
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: John RAMUNAS, Eduard YAKUBOV, Helen M. BLAU, John COOKE
  • Compounds, Compositions, Methods, and Kits Relating to Telomere Extension
    Publication number: 20140242155
    Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.
    Type: Application
    Filed: February 22, 2014
    Publication date: August 28, 2014
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: John RAMUNAS, Eduard YAKUBOV, Helen M. BLAU, John COOKE
  • LIPOSOMAL MITIGATION OF DRUG-INDUCED LONG QT SYNDROME AND POTASSIUM DELAYED-RECTIFIER CURRENT
    Publication number: 20140242156
    Abstract: Compositions and methods for the treatment of drug-induced long QT syndrome and other cardiac channelopathies are disclosed herein. The compositions and methods of the present invention comprise binding one or more QT prolonging drugs with a liposome prior to parenteral (intravenous or subcutaneous) administration, or administration of an empty liposome prior to or concomitantly with therapeutic agents known to have a high risk of QT prolongation, or immediately following an envenomation. The results presented show an abrogation of the adverse effects of QT prolonging drugs in a dose-dependent manner by the compositions of the present invention.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: SignPath Pharma Inc.
    Inventor: Lawrence Helson
  • EPICATECHIN COMPOSITIONS AND METHODS
    Publication number: 20140242157
    Abstract: Provided herein are methods and compositions for treating a subject who has pulmonary damage or an injury caused by or who is at risk for an injury caused by an anti-vesicant agent. The compositions comprise cacao extracts that include a mixture of epicatechin and one or more epicatechin oligomers and a pharmaceutically acceptable carrier. Also provided are methods for fermenting cacao to enhance epicatechin and antioxidant content.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: CACAO BIO-TECHNOLOGIES, LLC
    Inventors: Daniel PRESTON, Randall B. MURPHY
  • Granular Pharmaceutical Composition
    Publication number: 20140242158
    Abstract: The present invention relates to a granular pharmaceutical composition obtained by coating a nucleus with: (1) a layer containing a material having a damp-proofing function, and (2) a drug layer containing linaclotide, a pharmaceutically acceptable salt, or a hydrate thereof, and (3) a layer containing a material having a damp-proofing function. Also, the present invention relates to a method for manufacturing the granular pharmaceutical composition obtained by coating the nucleus with (1) the layer containing the material having a damp-proofing function, (2) the drug layer containing the linaclotide, the pharmaceutically acceptable salt, or the hydrate thereof, and (3) the layer containing the material having a damp-proofing function.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 28, 2014
    Applicant: Astellas Pharma, Inc.
    Inventors: Mare Nishiura, Kenichi Ashihara, Kanehira Imai, Atsushi Muro, Tsukasa Nishikawahara
  • Method for Preparing a Granulate Formulation of Pirfenidone and Pharmaceutically Acceptable Excipients
    Publication number: 20140242159
    Abstract: A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: INTERMUNE, INC.
    Inventors: Ramachandran Radhakrishnan, Ronald Vladyka, Kenneth Sultzbaugh
  • CALCIUM SUPPLEMENT
    Publication number: 20140242160
    Abstract: An oral dosage form for administration to an animal comprising a biologically utilizable form of calcium and an extended release system that maintains the calcium level in the animal's bloodstream at a substantially beneficial level for a defined period of time.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Pradnya BEKE, Ashish PATEL, Stephanie Petaway-Hickson
  • SOFT GELATIN CAPSULES
    Publication number: 20140242161
    Abstract: The present invention relates to soft gelatin capsules characterized in that the shell includes a cyclodextrin and in that the filling material contains a liposoluble drug capable of forming a complex with said cyclodextrin for improving the solubility of the active ingredient upon disintegration of the soft gelatin capsule.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 28, 2014
    Inventors: Giorgio ZOPPETTI, Maurizio MARCHIORRI
  • PHARMACEUTICAL COMPOSITIONS COMPRISING 40 - O - ( 2 - HYDROXY) ETHYL - RAPAMYCIN
    Publication number: 20140242162
    Abstract: The invention relates to extended release pharmaceutical formulations in form of multiparticulates comprising 40-O-(2-hydroxy)ethyl-rapamycin, to dosage forms which comprise said pharmaceutical formulations, to methods of preparing said pharmaceutical formulations and said dosage forms, to uses of said pharmaceutical formulations and said dosage for the manufacture of a medicament for the treatment or prevention of diseases or conditions responsive to inhibition of mTOR signaling pathway, such as for instance proliferative diseases or immunosuppression.
    Type: Application
    Filed: October 3, 2012
    Publication date: August 28, 2014
    Inventors: Anke Diederich, Kurt Liechti, Peter Kuehl, Wing Cheung
  • AMANTADINE COMPOSITIONS AND METHODS OF USE
    Publication number: 20140242163
    Abstract: Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: Adamas Pharmaceuticals, Inc.
    Inventors: Gregory T. Went, Gayatri Sathyan, Kavita Vermani, Gangadhara Ganapati, Michael Coffee, Efraim Shek, Ashok Katdare
  • COMPOSITION AND METHOD OF OBTAINING ORAL OR ENTERAL DOSAGE FORMS OF PHYTOCHEMICALS FROM POMEGRANATES
    Publication number: 20140242164
    Abstract: Nutraceutical compositions for improved administration of important phytochemicals from pomegranate to a human or animal. More particularly, enables oral or enteral dosage forms containing phytochemicals from pomegranate for administering on a routine basis. In at least one instance the natural contents of a pomegranate are encapsulated into a pill form or concentrated juice that provides for more efficient administration than eating a pomegranate but contains the same key ingredients present in the fruit. Enables the recipient to receive the benefits of the fruit but allows for the dosages to be taken in pill or concentrated juice form. Composition is chemically similar or equal to a natural pomegranate but is in a powder, pill or concentrated liquid form.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: POM Wonderful, LLC
    Inventors: Steve Anderson, Mark Dreher
  • Biocompatible Carrier Containing A Bioadhesive Material
    Publication number: 20140242165
    Abstract: A biocompatible carrier for delivery of a therapeutic substance or an active agent is disclosed. The carrier contains a bioadhesive material allowing for increased residence time of the active agent at the treatment site.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventor: Wouter E. Roorda
  • SUSTAINED RELEASE MATRIX SYSTEMS FOR HIGHLY SOLUBLE DRUGS
    Publication number: 20140242166
    Abstract: Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a sustained release matrix comprising a gelling agent, said gelling agent comprising a heteropolysaccharide gum and a homopolysaccharide gum capable of cross-linking said heteropolysaccharide gum when exposed to an environmental fluid, said dosage form providing a sustained release of said medicament after oral administration to human patients.
    Type: Application
    Filed: March 3, 2014
    Publication date: August 28, 2014
    Applicant: Penwest Pharmaceuticals Co.
    Inventors: Anand R. Baichwal, Troy W McCALL, Lirong LlU, Steve LABUDZINSKI
  • PHARMACEUTICAL COMPOSITIONS FOR GLUCOCORTICOID REPLACEMENT THERAPY
    Publication number: 20140242167
    Abstract: The invention relates to glucocorticoid replacement therapy and provides pharmaceutical compositions and kits designed to deliver one or more glucocorticoids to a subject in need thereon in a manner that results in serum levels of the glucocorticoid that essentially mimic that of a healthy subject for a clinically relevant period of time. The pharmaceutical compositions and kits are prepared in such a way that a first part of one or more glucocorticoids is substantially immediately released and a second part of one or more glucocorticoids is released over an extended period of time of at least about 8 hours. The invention also relates to a method for treating diseases requiring glucocorticoid treatment such as in subjects having a glucocorticoid deficiency disorder.
    Type: Application
    Filed: April 17, 2014
    Publication date: August 28, 2014
    Applicant: DuoCort Pharma AB
    Inventors: Stanko SKRTIC, Jörgen JOHNSSON, Hans LENNERNÄS, Thomas HEDNER, Gudmundur JOHANNSSON
  • SWELLABLE COATED TABLET
    Publication number: 20140242168
    Abstract: The present invention provides perorally administrable drug release systems and processes for producing perorally administrable systems having a drug-containing core and a sheath which surrounds the core and comprises a swellable shell and an elastic coating which surrounds at least the shell, the sheath having at least one orifice.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Christiane Schiller, Knut Seidlitz
  • TAPENTADOL COMPOSITIONS
    Publication number: 20140242169
    Abstract: The present invention provides a method of treating pain and pain related conditions by administering to a patient in need thereof, a therapeutically effective amount of a slow release Tapentadol Hydrochloride and therapeutically effective amount of a second analgesic, wherein the second analgesic is gamma-aminobutyric acid (GABA) analogue. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a slow release Tapentadol Hydrochloride and a therapeutically effective amount of a second analgesic, wherein the second analgesic is gamma-aminobutyric acid (GABA) analogue.
    Type: Application
    Filed: May 13, 2014
    Publication date: August 28, 2014
    Applicant: GRUENENTHAL GMBH
    Inventor: RAMESH SESHA
  • Corticosteroids for the Treatment of Joint Pain
    Publication number: 20140242170
    Abstract: Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.
    Type: Application
    Filed: December 16, 2013
    Publication date: August 28, 2014
    Applicant: FLEXION THERAPEUTICS, INC.
    Inventors: Neil Bodick, Robert C. Blanks, Anjali Kumar, Michael D. Clayman, Mark Moran
  • OIL-IN-WATER EMULSION OF MOMETASONE AND PROPYLENE GLYCOL
    Publication number: 20140242171
    Abstract: Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect. The compositions contain mometasone in micronised form, propylene glycol and water and the weight ratio between the propylene glycol and water contained in the oil-in-water emulsion is from 1:1 to about 1:3.
    Type: Application
    Filed: February 24, 2014
    Publication date: August 28, 2014
    Applicant: GALENICA AB
    Inventors: Henri Hansson, Anna Karin Morén
  • Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
    Publication number: 20140242172
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
    Publication number: 20140242173
    Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston, Grayson B. Lipford
  • TREATING COUGH AND TUSSIVE ATTACKS
    Publication number: 20140242174
    Abstract: The invention is directed towards carcainium in the form of a salt having an anion An?, wherein An? is an anion of pharmaceutically acceptable acid for use in the treatment and/or suppression of cough, tussive attacks or tussive episodes in a patient.
    Type: Application
    Filed: September 6, 2012
    Publication date: August 28, 2014
    Applicant: VERONA PHARMA PLC
    Inventor: Michael J.A. Walker
  • NANO-ENCAPSULATED, CONTROLLED DRUG DELIVERY, MANUFACTURING PROCESS AND SYSTEM
    Publication number: 20140242175
    Abstract: A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one layer of a protective material having the same core drug or different core drug. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one shell of a protective material with same drug concentration or different drug concentrations. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated such that to have different release schedule than the other portions of the drug. Methods and systems for the manufacturing and the administration of nanosized encapsulated drugs are also provided.
    Type: Application
    Filed: February 22, 2013
    Publication date: August 28, 2014
    Inventor: Albert Solur Zeng
  • COMPOSITIONS, METHODS, AND DEVICES FOR THE TREATMENT OF EYE STAIN
    Publication number: 20140242176
    Abstract: Embodiments provided herein relate to compositions, methods, and devices useful for treating eye stain. More particularly, compositions and devices are provided that include tylosin and a carrier suitable for ophthalmic application. Such compositions and devices can be used to treat eye stain in an animal, such as a dog or cat.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Applicant: Ader Enterprises, Inc.
    Inventor: Emilio Robledo
  • EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE
    Publication number: 20140242177
    Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.
    Type: Application
    Filed: October 19, 2012
    Publication date: August 28, 2014
    Applicant: NOVA SOUTHEASTERN UNIVERSITY
    Inventors: Mutasem Rawas-Qalaji, Keith Simons, Estelle Simons, Ousama Rachid
  • TASTE-MASKED FORMULATIONS OF RALTEGRAVIR
    Publication number: 20140242178
    Abstract: Disclosed are taste-masked pharmaceutical formulations of raltegravir comprising coated API granules mixed with a screened powder excipient blend in either tablet or sachet form. The core and coated granules are produced using a Wurster process for enhanced control of particle size. Also disclosed are methods of treating HIV, e.g., in pediatric populations.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 28, 2014
    Inventors: Karen Cassidy Thompson, Kimberly Nicole Kaighn, Indra Neil Mukherjee, Catherine Elizabeth Diimmler, Hedy Teppler Weiser, Christopher Mancinelli
  • NOVEL COATING SYSTEM
    Publication number: 20140242179
    Abstract: The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.
    Type: Application
    Filed: October 11, 2012
    Publication date: August 28, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Sylvain Diguet, Bruno H. Leuenberger, Fabien Laboulfie, Mehrdji Hemati
  • NANOPARTICLES FOR CONTROLLING BLEEDING AND DRUG DELIVERY
    Publication number: 20140242180
    Abstract: A temperature stable nanoparticle is provided comprising a core, a water soluble polymer and a peptide, the water soluble polymer attached to the core at a first terminus of the water soluble polymer, the peptide attached to a second terminus of the water soluble polymer, the peptide comprising an RGD amino acid sequence, the water soluble polymer of having sufficient length to allow binding of the peptide to glycoprotein lib/Ilia (GPIIb/llla). In one aspect, the nanoparticle has a melting temperature over 35° C. In various aspects, the nanoparticle has a spheroid shape and a diameter of less than 1 micron.
    Type: Application
    Filed: October 12, 2012
    Publication date: August 28, 2014
    Inventors: Erin Lavik, Andrew Shoffstall, Jeffrey Ustin
  • PREPARATION OF FIBRIN GEL FOR USE AS IMPLANT SYSTEM
    Publication number: 20140242181
    Abstract: The present invention aims to generate a fibrin gel for cell proliferation and transport using the patient's own blood or compatible blood. The gel-preparation process consists in taking a quantity of blood from the patient, using sodium citrate as anticoagulant, separating off the citrated plasma by centrifugation, and resuspending the cells to be transported in the plasma. CaCl2 is added to the resulting suspension to form the gel (either as an isolated coagulate or within a porous chitosan, gelatin or hyaluronic acid matrix), and the gel is cultured in an incubator to promote cell growth. The invention will be of use in cell growth for the purposes of implantation in cutaneous, cartilaginous, gingival and bone lesions, inter alias, and in the field of tissue engineering.
    Type: Application
    Filed: August 3, 2012
    Publication date: August 28, 2014
    Inventors: Manuel Eduardo Young Anze, Carolina Ruth Weinstein Oppenheimer, Donald Irving Brown Gonzalez, Miguel Angel Fuentes Chandia, Ricardo Andres Ceriani Fernandez, Fernando Antonio Albornoz Marquez, Cristian Andres Acevedo Gutierrez
  • FORMULATIONS THAT STABILIZE PROTEINS
    Publication number: 20140242182
    Abstract: In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate. In some embodiments, the protein is a therapeutic protein. In some embodiments, the therapeutic protein is antithrombin.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Applicant: rEVO Biologics, Inc
    Inventors: Sean A. Evans, Greg J. Allard, Nicholas C. Masiello
  • Compositions for Regenerating Defective or Absent Myocardium
    Publication number: 20140242183
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Inventor: Robert G. Matheny
  • Compositions for Regenerating Defective or Absent Myocardium
    Publication number: 20140242184
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Inventor: Robert G Matheny
  • Method of Enhancing Health of a Person
    Publication number: 20140242185
    Abstract: A method of enhancing health of a person includes administering stable water clusters to persons having an autoimmune disease, pain, a chronic disease, a mental disease, a genetic disease from malfunction of a normal DNA, being an athlete for improving his performance and alleviating soreness, suffering from overworking, stress and toxins etc., by drinking a solution containing stable water clusters, swallowing small objects which contain the stable water clusters, putting a topical cream which contains the stable water clusters on skin, breathing the stable water clusters through mouth, putting drops which contain the stable water clusters into eyes, ears or nose, cleaning colon with solution that contains the stable water clusters, eating food that contains the stable water clusters, injecting solution that contain the stable water clusters into blood vessel etc.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 28, 2014
    Applicant: D&Y Technologies
    Inventors: Shui Yin Lo, David L. Gann
  • GUIDED BONE REGENERATION MEMBRANE AND MANUFACTURING METHOD THEREOF
    Publication number: 20140242186
    Abstract: A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electrospinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: ORTHOREBIRTH CO. LTD.
    Inventors: Toshihiro Kasuga, Yoshio Ota, Takashi Wakita
  • Iron-Fiber Composition, Preparation and Uses Thereof
    Publication number: 20140242187
    Abstract: Compositions comprising ferrous and/or ferric iron compounds and fiber in a complex, methods for preparing such compositions of matter, and the use thereof for treatment of adsorbing certain accessible targets in the gastrointestinal tract and in an extracorporeal system, are provided herein.
    Type: Application
    Filed: October 12, 2012
    Publication date: August 28, 2014
    Inventor: Jinshyun Ruth Wu-Wong
  • Antimicrobial Compositions and Methods Employing Same
    Publication number: 20140242188
    Abstract: An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.
    Type: Application
    Filed: October 8, 2012
    Publication date: August 28, 2014
    Applicant: Next Science, LLC
    Inventor: Matthew Franco Myntti
  • METHODS OF TREATING GASTROINTESTINAL SPASMS TRIGGERED BY STRESS
    Publication number: 20140242189
    Abstract: Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: LiveLeaf, Inc.
    Inventors: ALEXANDER L. HUANG, Gin Wu
  • USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA
    Publication number: 20140242190
    Abstract: Methods for preventing and/or reducing side effects of an anti-cancer agent in a subject in need thereof are disclosed. The method comprises administering to the subject, who is under an anti-cancer agent treatment, a composition comprising a therapeutically effective amount of isolated deoxyelephantopin and/or an analogue thereof; and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: Academia Sinica
    Inventors: Lie-Fen SHYUR, Wen-Wan CHAO, Ya-Wen CHENG
  • Prevention of Starch Degradation in Pulp, Paper or Board Making Processes
    Publication number: 20140242191
    Abstract: The invention relates to biocidal systems comprising zinc ions and an oxidizing or non-oxidizing biocide, their use, and methods for preventing or decreasing starch degradation in starch-containing process waters from pulp, paper or board production processes.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 28, 2014
    Inventors: Marko Kolari, Jaakko Ekman, Satu Ikävalko
  • Clusterin Antisense Therapy for Treatment of Cancer
    Publication number: 20140242192
    Abstract: A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefits in the treatment of cancer comprising administering from 40 to 640 mg anti-clusterin antisense oligonucleotide to a patient in need of treatment for a cancer expressing clusterin is provided. The method may include administering chemotherapeutic agent or agents, radiotherapy, and/or hormone ablation therapy. The invention also encompasses pharmaceutical compositions formulated to provide a dosage of 40 to 640 mg, and use of antisense in formulating a medicament.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 28, 2014
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Martin E. Gleave, Scott D. Cormack
  • LITHIUM COMPOSITIONS
    Publication number: 20140242193
    Abstract: 2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms.
    Type: Application
    Filed: March 26, 2012
    Publication date: August 28, 2014
    Applicant: University of South Florida
    Inventors: Michael John Zaworotko, Roland D. Shytle, Tien Teng Ong, Padmini Kavuru, Ryan N. Cantwell, Tranhha Nguyen, Adam John Smith
  • USE OF NITRITE SALTS IN TREATING TISSUE DAMAGE
    Publication number: 20140242194
    Abstract: Methods of treating a subject who has an tissue damage or who is at risk for tissue necrosis are disclosed. Also disclosed are methods of treating a subject who has an inflammatory disorder. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to reduce the tissue damage. The subject can be diagnosed as having a medical condition that results tissue damage, for example, diabetes, peripheral artery disease, cardiovascular disease, defective wound healing, arthritis, inflammatory bowel disease, ischemia, or a bacterial infection, e.g., Group A staphylococcal infection. The methods can include the step of monitoring the course of treatment.
    Type: Application
    Filed: December 12, 2013
    Publication date: August 28, 2014
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical college
    Inventor: Christopher KEVIL
  • AUTOMOTIVE SURFACE CONDITIONING SYSTEM
    Publication number: 20140242195
    Abstract: An automotive surface treatment system can include an aqueous antimicrobial composition which is formulated for use with automotive surfaces and has a volatile organic content no greater than 0.5% by weight. The aqueous antimicrobial composition includes an antimicrobial agent which is a combination of quaternary ammonium salts, a combination of surfactants which is at least one polyoxyalkylene surfactant, a fragrance, water, and at least one of a glycol solvent, a conditioner, a shine enhancer, a moisturizer, and UV protectant. The system also includes a dispense container which is adapted to retain the antimicrobial composition within the container and instructions attached to the dispenser. The instructions include directions to apply the antimicrobial composition to an automotive surface.
    Type: Application
    Filed: February 13, 2014
    Publication date: August 28, 2014
    Applicant: American Covers, Inc.
    Inventor: Deborah E. Dixon
  • METHOD OF TREATING VENOMOUS BITES
    Publication number: 20140242196
    Abstract: The method of treating venomous bites, such as those from snakes and scorpions, involves treatment by the administration of a therapeutically effective amount of an aqueous extract of the fruit of Juniperus phoenicea, or pharmaceutically acceptable salts thereof. In order to treat the bites of venomous snakes, scorpions and the like, approximately 500 ml of an extract of the fruit of Juniperus phoenicea, or pharmaceutically acceptable salts thereof, is orally administered to a patient three times daily for a period of five days. In order to make the antivenin, formed as an extract of the fruit of Juniperus phoenicea, a quantity of the fruit of Juniperus phoenicea is ground, and then mixed with water. The mixture is then filtered to separate out the extract of Juniperus phoenicea, the filtrate forming the antivenin.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 28, 2014
    Applicant: UMM AL-QURA UNIVERSITY
    Inventor: SAEED SAEED K. ALGHAMDI