Patents Issued in November 27, 2014
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Publication number: 20140349828Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A fraction-density-altering solution may be added to a vessel that contains the sample to change the density of a first fraction of the sample without changing the density of the target material or the density of any other sample fraction. A collector may be inserted into the vessel to funnel the target material from the sample into the collector or into a processing receptacle included in the collector. In one implementation, the collector may include a cannula which extends into a chamber at a first end of the collector and a funnel at a second end that that is in fluid communication with the cannula. The chamber is sized and shaped to hold the processing receptacle. In another implementation, the processing receptacle may be inserted into a bore within the collector.Type: ApplicationFiled: May 1, 2014Publication date: November 27, 2014Applicant: RareCyte, Inc.Inventors: Lance U'ren, Joshua Nordberg, Daniel Campton, Steve Quarre, Ronald Seubert, David Stewart, Jennifer Chow, Jonathan Lundt
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Publication number: 20140349829Abstract: A rotor body (3) for a laboratory centrifuge includes a rotor hub (14) which is inserted in a central opening and on the outside of which, at least one helically curve continuous groove (27) runs so as to form a transport facility for cooling air. The cooling air is effective in the direction of the axis (2) of the rotor hub (14) between the upper side (23) and the underside (22) of the rotor (1). In this manner, a cooling airstream which runs axially through the rotor (1) and undergoes direct thermal exchange with the rotor (1) and the mixtures to be treated in the laboratory centrifuge can be realized. No additional installation volume is required for this measure and equalization of the temperature of the rotor and the housing accommodating the rotor can be achieved.Type: ApplicationFiled: July 24, 2013Publication date: November 27, 2014Applicant: SIGMA LABORZENTRIFUGEN GMBHInventors: Eckhard Todteberg, Matthias Bittner
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Publication number: 20140349830Abstract: A known method for producing synthetic quartz glass comprises: (a) reacting a carbonic silicon compound-containing raw material with oxygen in a reaction zone into SiO2 particles, (b) precipitating the SiO2 particles on a sedimentation area by forming a porous SiO2 soot body containing hydrogen and hydroxyl groups, (c) drying the porous SiO2 soot body, and (d) glazing to the synthetic quartz glass by heating the soot body up to a glazing temperature. In order to facilitate cost-efficient production of quartz glass by means of pyrolysing or hydrolysing a carbon-containing silicon compound using a carbon-containing raw material, the invention describes the production of a soot body with a carbon content within the range of 1 ppm by weight to 50 ppm by weight.Type: ApplicationFiled: December 12, 2012Publication date: November 27, 2014Inventors: Martin Trommer, Steffen Zwarg, Ralph Sattman, Bodo Kuehn
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Publication number: 20140349831Abstract: The invention relates to new glass formulations with alumina contents greater than 35 mol % and methods for making these glasses. The glass may be a porous glass or a dense glass.Type: ApplicationFiled: May 21, 2014Publication date: November 27, 2014Inventors: Ivan A. Cornejo, Ivar E. Reimanis
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Publication number: 20140349832Abstract: Ceramic nanocomposites and methods for manufacturing the ceramic nanocomposites are disclosed. One method includes introducing to a fired green ceramic body having a ceramic matrix submicron particles having coefficient of thermal expansion lower than the coefficient of thermal expansion of the ceramic matrix and at least one type of location-controlling dopant at an amount that is sufficient to cover the majority of the ceramic matrix grain boundaries. One ceramic nanocomposite includes a ceramic matrix with submicron particles dispersed in the ceramic matrix, the submicron particles having a coefficient of thermal expansion lower than the coefficient of thermal expansion of the ceramic matrix and at least one dopant that covers the majority of the ceramic matrix grain boundaries, at a concentration that does not exceed the bulk solubility limit of the dopant in the ceramic matrix at the ceramic nanocomposite sintering temperature.Type: ApplicationFiled: August 11, 2014Publication date: November 27, 2014Inventors: Wayne David KAPLAN, Gali Gluzer, Moshe Katz, Gil Perlberg
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Publication number: 20140349833Abstract: The invention relates to a blend for the production of a sintered refractory material containing chromium oxide, a sintered refractory material containing chromium oxide, a method for the manufacture of a sintered refractory material containing chromium oxide and to a use of magnesium titanate.Type: ApplicationFiled: April 24, 2013Publication date: November 27, 2014Inventors: Boro Djuricic, Roland Nilica, Klaus Santowski
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Publication number: 20140349834Abstract: Disclosed is a composition for ferroelectric thin film formation which is used in the formation of a ferroelectric thin film of one material selected from the group consisting of PLZT, PZT, and PT. The composition for ferroelectric thin film formation is a liquid composition for the formation of a thin film of a mixed composite metal oxide formed of a mixture of a composite metal oxide (A) represented by general formula (1): (PbxLay)(ZrzTi(1-z))O3 [wherein 0.9<x<1.3, 0?y<0.1, and 0?z<0.9 are satisfied] with a composite oxide (B) or a carboxylic acid (B) represented by general formula (2): CnH2n+1COOH [wherein 3?n?7 is satisfied]. The composite oxide (B) contains one or at least two elements selected from the group consisting of P (phosphorus), Si, Ce, and Bi and one or at least two elements selected from the group consisting of Sn, Sm, Nd, and Y (yttrium).Type: ApplicationFiled: July 31, 2014Publication date: November 27, 2014Inventors: Jun Fujii, Hideaki Sakurai, Takashi Noguchi, Nobuyuki Soyama
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Publication number: 20140349835Abstract: The present invention relates to compositions containing stabilized and/or activated urease inhibitors, as well methods of making and using the same.Type: ApplicationFiled: July 22, 2014Publication date: November 27, 2014Inventors: ZHENG TAN, GOPAL C. GOYAL, LINNEA J. SHAVER
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Publication number: 20140349836Abstract: The present invention relates to a method for preparing a nickel-based catalyst for steam carbon dioxide reforming (SCR) of natural gas using steam and carbon dioxide, more particularly to a method for preparing a nickel-based catalyst represented by Ni/?-Al2O3, which is prepared by supporting nickel on a spherical ?-alumina support having many acid sites at high density by repeating impregnation and drying tens of times. The catalyst prepared according to the present invention exhibits superior catalytic activity when used in steam carbon dioxide reforming reaction (SCR) even under harsh conditions of high temperature and high pressure and hardly exhibits carbon deposition due to superior durability.Type: ApplicationFiled: April 30, 2014Publication date: November 27, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Dong Ju MOON, Jae Sun JUNG, Eun Hyeok YANG, Sang Woo KIM, Jae Suk LEE, Bang Hee KIM, Jong Tae JUNG, Hyun Jin KIM, Ga Ram CHOI, Byoung Sung AHN
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Publication number: 20140349837Abstract: A method of producing a plurality of fiber catalyst is disclosed, the method includes the steps of: mixing a plurality of fiber material and a solvent to form a solution; putting the solution into a modeling container, to form at least one specific shape fiber body; applying a shaping process to the specific shape fiber body; and cutting or milling the specific shape fiber body to form a plurality of fiber catalyst.Type: ApplicationFiled: January 7, 2014Publication date: November 27, 2014Applicant: GUNITECH CORP.Inventors: Hsin-Yi Kao, Tsai-Hsin Cheng, Po-Kuei Chou, Ssu-Tai Lin
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Publication number: 20140349838Abstract: A regenerated exhaust gas treatment catalyst regenerated by: a used catalyst coarse grinding step (S1) for coarsely grinding a used exhaust gas treatment catalyst; a separation step (S2) separating a coarsely ground material into coarse pieces and a fine powder; a used catalyst fine grinding step (S3); steps (S4) to (S7) for kneading the fine powder together with other raw materials, molding a kneaded material, and drying and burning a molded material to produce a base material; a fresh catalyst grinding step (S8); a slurry formation step (S9); a slurry coating step (S10) coating the surface of the base material with the slurry solution; and a coating drying step (S11) and a coating burning step (S12) for drying the base material that has been coated with the slurry solution and burning the base material at a temperature higher than that employed in the production of the exhaust gas treatment catalyst.Type: ApplicationFiled: August 6, 2014Publication date: November 27, 2014Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.Inventors: Yoshiaki Obayashi, Masashi Kiyosawa, Masanori Demoto
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Publication number: 20140349839Abstract: The invention relates to a monolithic porous material based on amorphous silica or activated alumina or on one of their mixtures, the material comprising substantially rectilinear capillary ducts that lie parallel to one another, and being intended to be used as packing in a chromatography column, characterised in that: the ducts have, relative to one another, a substantially uniform cross section; the cross-section of each duct is uniform over its entire length; the ducts pass right through the material; the volume of micropores smaller than 0.3 nm is smaller than 50% of the total porous volume of the material.Type: ApplicationFiled: September 17, 2012Publication date: November 27, 2014Inventor: Francois Parmentier
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Publication number: 20140349840Abstract: Disclosed herein is an ammonia oxidation catalyst for converting nitrogen oxides generated from a mobile source or fixed source into harmless nitrogen using ammonia as a reductant and preventing the formation of nitrogen oxides due to the oxidation of ammonia. The ammonia oxidation catalyst includes selective catalytic reductive zeolite sequentially impregnated with platinum and copper.Type: ApplicationFiled: May 2, 2014Publication date: November 27, 2014Applicant: HEESUNG CATALYSTS CORPORATIONInventors: Hyun Sik Han, Eun Seok Kim
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Publication number: 20140349841Abstract: Provided is a catalyst article for simultaneously remediating the nitrogen oxides (NOx), particulate matter, and gaseous hydrocarbons present in diesel engine exhaust streams. The catalyst article has a soot filter coated with a material effective in the Selective Catalytic Reduction (SCR) of NOx by a reductant, e.g., ammonia.Type: ApplicationFiled: August 8, 2014Publication date: November 27, 2014Inventors: Joseph A. Patchett, Joseph C. Dettling, Elizabeth A. Przybylski
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Publication number: 20140349842Abstract: A method of preparing a composite catalyst for polyester synthesis includes the steps of: 1) sequentially dissolving a titanium compound, a silicon compound and a tin compound in an organic solvent; 2) adding a water solution of an acidic compound or of an alkaline compound in the compound from step 1) to cause hydrolysis thereof and collecting a precipitate, and washing the hydrolysis precipitate with a deionized water to obtain the composite catalyst. The catalyst is not only effective in polyester production polycondensation, but also has significant catalytic activity in esterification. The produced polyester chips all have a desirable hue.Type: ApplicationFiled: May 31, 2013Publication date: November 27, 2014Inventors: Zuoxiang Zeng, Lujie Wang, Zhelong Li, Wanyu Zhu, Tao Han, Yan Shen
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Publication number: 20140349843Abstract: Methods for forming novel fuel cell catalysts are described. The catalyst has a physical structure that is the inverse image of a plurality of hierarchically structured sacrificial support particles. The particles may be formed independently and then infused with one or more transitional metallic salts and nitrogen carbon precursors, or the sacrificial support precursors, transitional metallic salts, and nitrogen carbon precursors may all be combined in such a way that a hierarchically structured sacrificial support with the infused transitional metallic salts and nitrogen carbon precursors is formed in a single step. The infused sacrificial support is then pyrolized, at least once, and the sacrificial support is removed, resulting in the catalyst.Type: ApplicationFiled: September 17, 2012Publication date: November 27, 2014Applicant: STC.UNMInventors: Wendy Patterson, Michael Robson, Candace Walker, Alexey Serov, Barr Halevi, Kateryna Artyushkova, Plamen B. Atanassov
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Publication number: 20140349844Abstract: A selective nickel-based hydrogenation catalyst and the preparation thereof, characterized in that: provided that the catalyst is weighed 100%, it comprises nickel oxide 14-20% as active component, lanthanum oxide and/or cerium oxide 2-8%, and VIB element oxide 1-8% as aids, 2-8% silica, 1-8% alkaline earth metal oxides, and alumina as the balance. The catalyst specific surface area is 60-150 m2/g, and the pore volume is 0.4-0.6 ml/g. The catalyst has good hydrogenation performance, especially impurity and colloid resistance and hydrogenation stability. The catalyst can be applied to the diolefin selective hydrogenation of medium or low-distillate oil, especially of the full-distillates pyrolysis gasoline.Type: ApplicationFiled: August 11, 2014Publication date: November 27, 2014Inventors: Shunqin Liang, Ying Qian, Longgang Lv, Limin Sun, Yundi Zheng, Tinghai Wang, Jie Wu, Fengxia Cao
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Publication number: 20140349845Abstract: The present invention relates to a method for preparing a cobalt-based catalyst for Fischer-Tropsch synthesis, more particularly to a method for preparing a cobalt-based catalyst represented by Ir—Co/?-Al2O3 wherein cobalt and iridium are supported at high density by repeating impregnation and drying tens of times on a spherical ?-alumina support having many acidic sites. The catalyst prepared according to the present invention can provide improved conversion rate of carbon monoxide and selectivity for liquid hydrocarbons when used for Fischer-Tropsch synthesis.Type: ApplicationFiled: August 20, 2013Publication date: November 27, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Dong Ju MOON, Jae Sun JUNG, Jae Suk LEE, Eun Hyeok YANG, Hyun Jin KIM, Bang Hee KIM, Seung Hwan LEE, Yun Ju LEE, Ga Ram CHOI
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Publication number: 20140349846Abstract: Kitchenware comprising thermochromic and photochromic inks in zones of high visibility for the user are disclosed, as a mechanism to know by simple observation their thermal state (cold or hot), independently if said kitchenware is used outdoors (under sunlight exposure) or in enclosed areas. Said kitchenware corresponds to pots, frying pans, cooking pots, pressure cookers or any other kitchen utensil whose use may be outdoors or in enclosed areas and implies direct or indirect contact with a thermal energy source. Thermochromic and photochromic inks are applied in zones of the kitchenware where the user may easily see the color change during use, as in zones where there is no direct contact with food, which, depending on the type of kitchen utensil, may be in covers, knobs, grippers, handles, flame arrestors, regulator valves for pressure cookers, as in exterior walls that are not in direct contact with the thermal source.Type: ApplicationFiled: May 21, 2013Publication date: November 27, 2014Inventors: Alexis Juan TAHTA, Alejandro Restrepo ZEA
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Publication number: 20140349847Abstract: Plant propagation material treated with a carbonaceous material is provided. Such treated plant propagation material is useful in a method of inducing microbial interaction with the plant propagation material that confers a benefit on the plant propagation material. The method includes placing the treated plant propagation material in a growth medium containing endogenous soil microorganisms.Type: ApplicationFiled: November 30, 2012Publication date: November 27, 2014Inventor: Glen Schrader
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Publication number: 20140349848Abstract: The present invention provides fungicidal 4-substituted-3-{phenyl[(heterocyclylmethoxy)imino]methyl}-1,2,4-oxadiazol-5(4H)-one derivatives of formula (I) wherein A represents a pyridyl or thiazole group and X1, Y1 to Y5 represent independently different substituents.Type: ApplicationFiled: September 10, 2012Publication date: November 27, 2014Inventors: Christoph Braun, Haruko Sawada, Helene Lachaise, Stephane Brunet, Philippe Rinolfi, Christophe Dubost, Pierre-Yves Coqueron, Simon Maechling, Anne-Sophie Rebstock, Ulrike Wachendorff-Neumann
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Publication number: 20140349849Abstract: The invention relates to a method of finding compounds which increase the tolerance of plants to abiotic stress factors acting on this plant, such as, for example, temperature (such as chill, frost or heat), water (such as dryness, drought or anoxia), or the chemical load (such as lack of or excess of mineral salts, heavy metals, gaseous noxious substances) by increasing the expression of plant-endogenous proteins, and to the use of these compounds for increasing the tolerance in plants to abiotic stress factors.Type: ApplicationFiled: August 6, 2014Publication date: November 27, 2014Inventors: Arno Schulz, Klaus Bartsch, Hansjörg Krähmer, Martin Hills, Erwin Hacker, Chris Rosinger
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Publication number: 20140349850Abstract: The present invention relates to coated dehydrated microorganisms comprising a dehydrated microorganism surrounded by at least one coating, said coating comprising by dry weight at least 25% of hygroscopic salt(s) and wherein the pH of the coating is compatible with viability of the coated dehydrated microorganism. The coating can be partially crystalline, the salt(s) in the coating having preferably a crystallinity degree of up to 60% once applied onto the dehydrated microorganism. The present invention also relates to liquid coating compositions, methods for coating and protecting a dehydrated microorganism. Finally, the present invention relates to a method for the preparation of food products, feed products, consumer healthcare products or agri-products as well as to a food product, feed product, a consumer healthcare product or an agri-product containing such coated dehydrated microorganisms.Type: ApplicationFiled: August 13, 2014Publication date: November 27, 2014Inventors: Isabelle Mazeaud, Kathryn Tse, Jean-Philippe Obert, Claudette Berger, Geoffrey Babin, Patrick Chaigneau, Hans Hedegaard Jensen, Erwan Henri
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Publication number: 20140349851Abstract: Plant growth enhancing mixture and method of selectively timing the application of same during the development of crop plants or other plants to positively augment cell number increase and cellular development of crop plants or other plants to enhance development and/or productivity of the economic portion of the crop plant or other plant. Application of the plant growth enhancing mixture at flowering enhances both weak flowers and normally strong flowers. The plant growth enhancing mixture and method of application have also been shown to impart varying disease resistance to the treated crop or other plants. The plant growth enhancing mixture and method of application also increases the depth and strength of rooting for greater access and transport of water and nutrients for growth and productivity of the crop plant.Type: ApplicationFiled: June 3, 2014Publication date: November 27, 2014Applicant: STOLLER ENTERPRISES, INC.Inventors: Jerry Stoller, Albert Liptay, Ronald Salzman
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Publication number: 20140349852Abstract: This invention provides Methods of conveniently controlling seed germination in genetically modified plants by the administration of a chemical modulator. The plant comprises a hormone-regulating gene placed under the control of a gene switch.Type: ApplicationFiled: September 21, 2011Publication date: November 27, 2014Applicants: Oregon State University, Donald Danforth Plant Science CenterInventors: Roger Beachy, Hiroyuki Nonogaki
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Publication number: 20140349853Abstract: This invention is related to use of a volatile antimicrobial compound against pathogens affecting meats, plants, or plant parts. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. Also combinations with a volatile plant growth regulator, for example 1-methylcyclopropene, are disclosed.Type: ApplicationFiled: June 2, 2014Publication date: November 27, 2014Applicant: Dow AgroSciences LLCInventors: Daniel Maclean, David H. Young, Richard M. Jacobson, Maurice C. Yap, Rodrigo A. Cifuentes, Donald H. DeVries, Joseph D. Eckelbarger
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Publication number: 20140349854Abstract: Provided is an iron-based superconducting material including an iron-based superconductor having a crystal structure of ThCr2Si2, and nanoparticles which are expressed by BaXO3 (X represents one, two, or more kinds of elements selected from a group consisting of Zr, Sn, Hf, and Ti) and have a particle size of 30 nm or less. The nanoparticles are dispersed in a volume density of 1×1021m?3 or more.Type: ApplicationFiled: February 28, 2014Publication date: November 27, 2014Applicant: International Superconductivity Technology CenterInventors: Masashi Miura, Seiji Adachi, Keiichi Tanabe, Hideo Hosono
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Publication number: 20140349855Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.Type: ApplicationFiled: April 10, 2014Publication date: November 27, 2014Applicants: ADAPTIMMUNE LIMITED, IMMUNOCORE LIMITEDInventors: Bent Karsten Jakobsen, Torben Bent Andersen, Peter Eamon Molloy, Yi Li
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Publication number: 20140349856Abstract: The disclosure provides methods for the use of gene expression measurements to classify or identify neuroendocrine cancer in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.Type: ApplicationFiled: March 24, 2014Publication date: November 27, 2014Applicant: BIOTHERANOSTICS, INC.Inventors: Catherine A. Schnabel, Yi Zhang, Mark G. Erlander
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Publication number: 20140349857Abstract: The present invention relates to a method for in vitro diagnosis or prognosis of colon cancer, including a step of detecting at least one expression product of at least one HERV nucleic acid sequence, the use of said isolated nucleic acid sequences as a molecular marker/molecular markers, and a kit including at least one specific binding partner for at least one expression product of the HERV nucleic acid sequences.Type: ApplicationFiled: December 17, 2012Publication date: November 27, 2014Inventors: François Mallet, Nathalie Mugnier, Philippe Perot
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Publication number: 20140349858Abstract: The present invention relates to methods and compositions for tagging, amplifying, purifying, and or characterizing of ribonucleic acid (RNA) in a sample. In particular, methods are provided for preparing RNA from a sample for subsequent analysis.Type: ApplicationFiled: December 21, 2012Publication date: November 27, 2014Applicant: IBIS BIOSCIENCE, INC.Inventors: Stanley T. Motley, Mark W. Eshoo
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Publication number: 20140349859Abstract: The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.Type: ApplicationFiled: August 6, 2014Publication date: November 27, 2014Inventors: Arnold Oliphant, Jacob Zahn, Kara Juneau, Patrick Bogard, Stephanie Huang
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Publication number: 20140349860Abstract: The present invention relates to methods for identifying amino acids in peptides. In one embodiment, the present invention contemplates labeling the N-terminal amino acid with a first label and labeling an internal amino acid with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level.Type: ApplicationFiled: June 22, 2012Publication date: November 27, 2014Applicant: Board of Regents, The University of Texas SystemInventors: Edward Marcotte, Jagannath Swaminathan, Andrew Wllington, Eric Anslyn
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Publication number: 20140349861Abstract: A method for encoding and identifying biological materials is disclosed. The method may include encoding and identifying plants from which controlled substances may be derived and other materials for which movement and distribution may need to be tracked. The biological material may be first encoded using DNA oligomers. A spray method or the use of an encoded substrate, both using these DNA oligomers for encoding the biological material, may be employed. The biological material, or a part of the biological material, may be first encoded by atomizing a solution containing DNA oligomers onto it and then dried by an appropriate method. Thereafter, the part of the encoded biological material, or the nitrocellulose substrate, may be dissolved with a buffer solution for extracting the DNA oligomers. Then, the dissolved solution may be used for generating a barcode by a suitable detection scheme.Type: ApplicationFiled: May 22, 2013Publication date: November 27, 2014Applicant: Sunpower Technologies LLCInventor: Travis Jennings
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Publication number: 20140349862Abstract: Disclosed are methods and kits for pharmacokinetic profiling employing point-of-care or point of service self-sampling and allowing for dosage adjustments based on the pharmacokinetic profiles.Type: ApplicationFiled: May 30, 2012Publication date: November 27, 2014Inventor: Vuong Ngoc Trieu
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Publication number: 20140349863Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: March 1, 2013Publication date: November 27, 2014Applicant: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Publication number: 20140349864Abstract: The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to gene expression product markers, alternative exon usage markers, and DNA polymorphisms associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.Type: ApplicationFiled: November 21, 2013Publication date: November 27, 2014Applicant: Veracyte, Inc.Inventors: Giulia C. Kennedy, Bonnie H. Anderson, Darya I. Chudova, Eric T. Wang, Hui Wang, Moraima Pagan, Nusrat Rabbee, Jonathan I. Wilde
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Publication number: 20140349865Abstract: The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.Type: ApplicationFiled: November 26, 2013Publication date: November 27, 2014Applicant: NESTEC S.A.Inventors: Sharat Singh, Jeanne Harvey, Phillip Kim, Xinjun Liu, Limin Liu, Robert Barham, Bruce Neri
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Publication number: 20140349866Abstract: Methods are described for using genes crucial in TH17 differentiation, IL-12Rbeta 1/IL-23R, CCR6, BATF, AHR, STAT3 and IRF4 as new markers for rosacea. Also described, are methods of their use to diagnose rosacea, to screen inhibitors of Th17 differentiation. In particular, method are described for inhibiting at least one of these genes and using the screened inhibitors in rosacea treatment.Type: ApplicationFiled: June 25, 2012Publication date: November 27, 2014Applicant: GALDERMA RESEARCH & DEVELOPMENTInventor: Martin Steinhoff
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Publication number: 20140349867Abstract: A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.Type: ApplicationFiled: January 24, 2014Publication date: November 27, 2014Applicant: DeNovo Sciences, Inc.Inventors: Kalyan Handique, Priyadarshini Gogoi, Yi Zhou, Saedeh Sepehri Javdani
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Publication number: 20140349868Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.Type: ApplicationFiled: March 4, 2014Publication date: November 27, 2014Applicant: ALERE SAN DIEGO, INC.Inventors: GUNARS VALKIRS, PAUL H. MCPHERSON
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Publication number: 20140349869Abstract: Methods of detecting lung cancer, such as non-small cell lung cancer, including squamous cell carcinoma and adenocarcinoma, are provided. Methods of detecting changes in the levels of one or more small RNAs associated with lung cancer are also provided. Compositions and kits are also provided.Type: ApplicationFiled: April 30, 2014Publication date: November 27, 2014Applicant: CEPHEIDInventors: Bernard Michot, Olivier Delfour
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Publication number: 20140349870Abstract: A chemo-mechano-chemical (C1-M-C2) system includes a base supporting an actuatable structure, said structure comprising a functionalized portion and being embedded in an environmentally responsive gel capable of volume change in response to an environmental stimulus; a first fluid layer disposed over the base and in contact with the actuatable structure, said first fluid layer comprising the environmentally responsive gel; and a second fluid layer in contact with the actuatable structure, wherein the layers are positioned such that the functionalized portion is in contact with the second layer in a first relaxed state and in contact with the first layer in a second actuated state and wherein the functionalized portion interacts with at least one of the layers to provide a chemical or physical response.Type: ApplicationFiled: May 2, 2014Publication date: November 27, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Joanna AIZENBERG, Ximin HE, Michael AIZENBERG
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Publication number: 20140349871Abstract: Disclosed herein are methods for large-scale, high-throughput identification of protein-protein interactions and the topologies thereof under physiologically relevant conditions. In one aspect, the disclosure provides methods for identifying one or a plurality of interacting peptides within a biological system comprising obtaining a population of proteins cross-linked with a cleavable protein interaction reporter (PIR) cross-linker, cleaving the PIR crosslinker to produce released peptides and cleaved reporter ions, and analyzing the population of released peptides to identify interacting peptides. Also disclosed are methods for identifying candidate drug compounds, as well as methods of data processing and visualization of protein-protein interactions.Type: ApplicationFiled: May 21, 2014Publication date: November 27, 2014Inventors: James E. Bruce, Juan Chavez, Chad Weisbrod
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Publication number: 20140349872Abstract: Systems and methods for minimizing or eliminating steps in immunosorbent assays for single and multiple analytes by eliminating the need to attach target molecules to test well and the need to remove unbound antibodies through rinsing. Immunosorbent assay (ISA) is utilized for a single analyte and includes the step of mixing the immunologic molecules with the sample and detection. Immunosorbent assay for multiple analytes for testing a plurality of analytes in a single well is disclosed using a modified ISA test wherein different tags are attached to different antibody pairs. Alternate embodiments use multiple types of scavenger antigens with corresponding elimination of the need for scavenger antibodies. Various types of test wells are disclosed for rapid and simultaneous testing of fluids for a plurality of components and methodology for continuous immunosorbent assay. Method for immunosorbent assay of an analyte object having a plurality of distinct target antigens is also disclosed.Type: ApplicationFiled: May 23, 2014Publication date: November 27, 2014Applicant: CHIPOTLE BUSINESS GROUP, INC.Inventors: Norman Scott Evans, Derrick Charbonnet
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Publication number: 20140349873Abstract: Methods are described for the production and use of fluorescence resonance energy transfer (FRET)-based competitive displacement aptamer assay formats. The assay schemes involve FRET in which the analyte (target) is quencher (Q)-labeled and previously bound by a fluorophore (F)-labeled aptamer such that when unlabeled analyte is added to the system and excited by specific wavelengths of light, the fluorescence intensity of the system changes in proportion to the amount of unlabeled analyte added. Alternatively, the aptamer can be Q-labeled and previously bound to an F-labeled analyte so that when unlabeled analyte enters the system, the fluorescence intensity also changes in proportion to the amount of unlabeled analyte.Type: ApplicationFiled: June 3, 2014Publication date: November 27, 2014Inventors: John Bruno, Joseph Chanpong
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Publication number: 20140349874Abstract: One or more polymorphisms, including single nucleotide polymorphisms (SNPs), or combinations thereof, for diagnosis of cardiac disease, such as heart failure and atrial fibrillation.Type: ApplicationFiled: June 9, 2014Publication date: November 27, 2014Applicant: MOR RESEARCH APPLICATIONS LTD.Inventors: Offer AMIR, Basil S. LEWIS
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Publication number: 20140349875Abstract: A method for in vitro diagnosis of testicular cancer includes (i) obtaining a biological sample from a patient suspected of having testicular cancer, (ii) performing an assay to determine the methylation status of CpG dinucleotides in a genomic DNA target sequence, the DNA target sequence being the 5? LTR U3 promoter sequence of the ERVWE1 locus, optionally further including an activator sequence directly upstream of the 5? LTR U3 promoter sequence, and (iii) diagnosing the patient with testicular cancer when the DNA target sequence is hypomethylated as compared to a methylation status indicative of the absence of testicular cancer.Type: ApplicationFiled: July 14, 2014Publication date: November 27, 2014Inventors: Juliette GIMENEZ, Cecile MONTGIRAUD, Francois MALLET
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Publication number: 20140349876Abstract: According to the present invention, a sugarcane-stalk-sugar-content-related marker linked to a sugarcane quantitative trait is provided. Such marker is a sugarcane-stalk-sugar-content-related marker, which comprises a continuous nucleic acid region existing in a region sandwiched between the nucleotide sequence shown in SEQ ID NO: 1 and the nucleotide sequence shown in SEQ ID NO: 8 or a region sandwiched between the nucleotide sequence shown in SEQ ID NO: 9 and the nucleotide sequence shown in SEQ ID NO: 16.Type: ApplicationFiled: July 14, 2014Publication date: November 27, 2014Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Hiroyuki ENOKI, Tatsuro KIMURA, Shoko TSUZUKI, Satoru NISHIMURA, Aya MURAKAMI, Takayoshi TERAUCHI, Takeo SAKAIGAICHI, Taiichiro HATTORI, Shoko ISHIKAWA, Yoshifumi TERAJIMA
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Publication number: 20140349877Abstract: Methods and compositions for detecting and diagnosing Parkinson's disease are disclosed.Type: ApplicationFiled: December 7, 2012Publication date: November 27, 2014Inventors: Howard E. Gendelman, R. Lee Mosley, Jessica A. Saunders