Patents Issued in January 20, 2015
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Patent number: 8936742Abstract: The present invention relates to an integrated Assisting Cooling (AC) device, system and method for use with PED devices, allowing use of biopolymers having higher melting points in the fabrication of 3D scaffolds. The AC device cools the filament as it is extruding from the nozzle via low flow convective cooling. The AC device allows for cooling in the +/? direction of motion on an XY plane. The AC device elevates with the material delivery chamber. The AC device allows for scaffold fabrication at applied temperatures as high as about 250° C.Type: GrantFiled: September 23, 2011Date of Patent: January 20, 2015Assignee: Drexel UniversityInventors: Wei Sun, Qudus Hamid
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Patent number: 8936743Abstract: A method of making a polylactic acid based article includes: (a) providing a sheet having a crystallinity ranging from 0% to 15% and including a polylactic acid polymer composition, the polylactic acid polymer composition having a polylactic acid polymer, a copolyester polymer, and a crystal nucleating agent; (b) heating the sheet to maintain a surface of the sheet at a temperature ranging from 95° C. to 105° C. while keeping the crystallinity of the sheet lower than 20%; and (c) thermoforming the sheet in a mold having a temperature ranging from 95° C. to 130° C. so as to form a polylactic acid based article having a crystallinity ranging from 35% to 45%.Type: GrantFiled: October 31, 2011Date of Patent: January 20, 2015Assignee: Far Eastern New Century CorporationInventors: Chi-Wei Ciou, Li-Ling Chang, Roy Wu
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Patent number: 8936744Abstract: There are provided a fluorine-containing photocurable resin composition and a method of preparing a mold comprising the same and more particularly, a photocurable resin composition having chemical resistance, mechanical properties and high transmittance, etc. as well as being easily wetted with and released from thermosetting or photocurable resins for pattern formation regardless of additional surface treatment, as opposed to the existing polymer resin materials used for resin molds, and a method of preparing a resin mold using the same.Type: GrantFiled: July 7, 2010Date of Patent: January 20, 2015Assignee: Dongjin Semichem Co., Ltd.Inventors: Jae-won Yoo, Byung-uk Kim, Un-yong Kim, Eun-jin Kwak
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Patent number: 8936745Abstract: The present invention relates to a method of fabricating a painted substrate (30) using powder paint (21), said substrate being electrically insulating, during which method the following steps are performed in succession: a) a treatment coating (10) is placed on a mold (1), said treatment coating (10) including at least one preparation layer (11, 12) based on an unmolding agent (15, 15?) in contact with said mold (1); b) said treatment coating (10) is electrostatically covered with powder paint (21) in such a manner that said powder paint (21) is attracted towards said mold (1) and is held against the treatment coating (10); c) said powder paint (21) is transformed at least in part in order to obtain a sheet (20) of powder paint (21); and d) said substrate (30) is prepared on said sheet (20) in order to obtain said painted substrate.Type: GrantFiled: May 14, 2009Date of Patent: January 20, 2015Assignee: Airbus HelicoptersInventors: Claire Chairat, Olivier Burel, Jean-Marc Berthier
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Patent number: 8936746Abstract: An extension for a heating element includes a bracket for a quartz lamp within a furnace of a blow molding machine. The extension includes a base that is coupled to the furnace where the extension directs the heating element toward an end of a preform. The extension may include a parabolic lens to provide controlled and directed heating of the end of the preform to optimize material distribution upon blow molding.Type: GrantFiled: November 1, 2011Date of Patent: January 20, 2015Assignee: Plastic Technologies, Inc.Inventors: Donald Wayne Miller, Dennis Hahn
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Patent number: 8936747Abstract: A method for manufacturing a honeycomb structure includes extrusion-molding honeycomb molded bodies. The honeycomb molded bodies are fired to form honeycomb fired bodies. A molding frame optionally having a vent portion with air permeability is provided. The honeycomb fired bodies are fixed in the molding frame. A member having an other vent portion with air permeability is optionally disposed on an inner face side of the molding frame. A gap between the honeycomb fired bodies and a gap between the molding frame and the honeycomb fired bodies are filled with a sealing material paste. The sealing material paste includes inorganic particles and/or inorganic fibers. The sealing material paste is dried to solidify the sealing material paste and to form an adhesive layer and a coat layer. The sealing material paste is in contact with at least a part of the vent portion during the drying.Type: GrantFiled: April 27, 2011Date of Patent: January 20, 2015Assignee: Ibiden Co., Ltd.Inventors: Kazuya Naruse, Tomohiro Takano, Hideki Sugino
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Patent number: 8936748Abstract: Artificial turf has a base layer, a multiplicity of blades fixed in and projecting upward from the base layer, and a mass of damping material on the base layer and through which the blades project. Each of the blades is at least partially formed of a polyester of terephthalic acid made from waste. The polyester is polyethylene terephthalate (PET) or polybutylene terephthalate (PBT), both from waste. The base layer is a flat primary layer, preferably a textile and preferably consists of plastic, a polyolefin and/or a polyester of terephthalic acid, preferably a polyester of terephthalic acid from waste.Type: GrantFiled: August 16, 2012Date of Patent: January 20, 2015Assignee: Reifenhaeuser GmbH & Co. KG MaschinenfabrikInventor: Juergen Morton-Finger
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Patent number: 8936749Abstract: An apparatus for injecting gas into a vessel is disclosed. The apparatus comprises a gas flow duct from which to discharge gas from the duct, an elongate central structure extending within the gas flow duct from its rear end to its forward end, and a plurality of flow directing vanes disposed about the central structure adjacent the forward end of the duct. The forward end of the central structure and the vanes are water cooled by separate supply passages.Type: GrantFiled: December 11, 2009Date of Patent: January 20, 2015Assignee: Technological Resources Pty. LimitedInventor: Barry Alan Cady
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Patent number: 8936750Abstract: A method of preparing a functionally graded cemented tungsten carbide material via heat treating a sintered cemented tungsten carbide is disclosed and described. The heat treating process comprises at least a step that heats the sintered material to the multi-phase non-equilibrium temperature range in which multiple phases including solid tungsten carbide, liquid metal binder, and solid metal binder coexist. Additionally, the material, after the heat treating process comprises a surface layer with lower metal binder content than the nominal value of metal binder content of the bulk of the material.Type: GrantFiled: November 19, 2009Date of Patent: January 20, 2015Assignee: University of Utah Research FoundationInventors: Zhigang Z. Fang, Peng Fan, Jun Guo
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Patent number: 8936751Abstract: A multiphase composite system is made by binding hard particles, such as TiC particles, of various sizes with a mixture of titanium powder and aluminum, nickel, and titanium in a master alloy or as elemental materials to produce a composite system that has advantageous energy absorbing characteristics. The multiple phases of this composite system include an aggregate phase of hard particles bound with a matrix phase. The matrix phase has at least two phases with varying amounts of aluminum, nickel, and titanium. The matrix phase forms a bond with the hard particles and has varying degrees of hard and ductile phases. The composite system may be used alone or bonded to other materials such as bodies of titanium or ceramic in the manufacture of ballistic armor tiles.Type: GrantFiled: July 24, 2012Date of Patent: January 20, 2015Inventor: Robert G. Lee
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Patent number: 8936752Abstract: A sample analyzer is disclosed. The sample analyzer comprises: a reader for reading ID of a sample from a sample container; an aspirator that aspirates a sample in a sample container; an analyzing section that analyzes the aspirated sample; a manual input receiver for receiving a manual input of an ID of a sample; an start instruction receiver for receiving a start instruction to cause the aspirator to aspirate a sample; and a controller. When receiving the start instruction without receiving the manual input, the controller controls the reader to read an ID from a sample container and then controls the aspirator to aspirate the sample from the sample container. When receiving the start instruction after receiving the manual input, the controller controls the aspirator to aspirate a sample without reading of an ID of the sample.Type: GrantFiled: November 30, 2011Date of Patent: January 20, 2015Assignee: Sysmex CorporationInventor: Keisuke Kuwano
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Patent number: 8936753Abstract: A blood coagulation analyzer includes a detector and a controller. The detector includes a light source for emitting light to a prepared measurement sample and a light-receiving section for receiving light transmitted through the measurement sample. The controller is configured to performs operations comprising acquiring, based on the light detected by the detector, ratio information reflecting a ratio between a first value reflecting the intensity of the light transmitted through the measurement sample of a clotting reaction starting stage and a second value reflecting the intensity of the light transmitted through the measurement sample of a clotting reacting ending stage, and acquiring, based on the ratio information, a fibrinogen concentration in the blood sample.Type: GrantFiled: September 29, 2010Date of Patent: January 20, 2015Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Hiroyuki Fujino, Takamichi Naito, Naohiko Matsuo, Susumu Hoshiko
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Patent number: 8936754Abstract: There is provided a high-accuracy automatic analysis device achieving both of measurement in a wide concentration range and high sensitivity at a low concentration. The signals of a plurality of wavelengths ?1 to ?12 where the sensitivity of light absorption caused by fine particles is high from a light source 40 are converted to absorbances by a spectroscopic optical system (detector) 41. The absorbances are converted to a secondary parameter from in which a noise component is cancelled by using a previously-defined conversion table 54, so that a concentration of a measured material (predetermined component) is calculated by an operation unit (calculating means) 53 based on the secondary parameter. Thus, analysis being resistant to the noise even at the low concentration can be achieved in a range up to a high concentration.Type: GrantFiled: November 12, 2009Date of Patent: January 20, 2015Assignee: Hitachi High-Technologies CorporationInventors: Isao Yamazaki, Hiroaki Ishizawa, Sakuichiro Adachi
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Patent number: 8936755Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.Type: GrantFiled: March 16, 2012Date of Patent: January 20, 2015Assignee: OptiScan Biomedical CorporationInventors: Jennifer H. Gable, James R. Braig, Kenneth I. Li, Mark Wechsler, Peng Zheng, Richard Keenan
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Patent number: 8936756Abstract: The apparatus herein provide a catalyst cooler with a vent that communicates fluidizing gas to a lower chamber of a regenerator. Air that is used as fluidizing gas can then be consumed in the regenerator without promoting after burn in the upper chamber.Type: GrantFiled: February 28, 2011Date of Patent: January 20, 2015Assignee: UOP LLCInventors: Paolo Palmas, Daniel N. Myers
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Patent number: 8936757Abstract: Apparatuses and processes are provided for stripping gaseous hydrocarbons from particulate material. One process comprises the step of contacting particles containing hydrocarbons with a stripping vapor in countercurrent flow to remove at least a portion of the hydrocarbons with the stripping vapor to form stripped particles. Contacting the particles includes advancing the particles down a sloping element of a structured packing toward a reinforcing rod that is disposed along a lower channel portion of the sloping element. The particles are advanced over the reinforcing rod. The particles are contacted with the stripping vapor that is rising up adjacent to the lower channel portion.Type: GrantFiled: December 28, 2011Date of Patent: January 20, 2015Assignee: UOP LLCInventors: Erick D. Gamas-Castellanos, Mitchell John Kowalczyk
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Patent number: 8936758Abstract: A process and apparatus for mixing streams of regenerated and carbonized catalyst involves passing a catalyst stream around an insert in a lower section of a riser. The insert fosters mixing of the catalyst streams to reduce their temperature differential before contacting hydrocarbon feed.Type: GrantFiled: March 20, 2012Date of Patent: January 20, 2015Assignee: UOP LLCInventors: Paolo Palmas, Mohammad-Reza Mostofi-Ashtiani, Lev Davydov
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Patent number: 8936759Abstract: A double helix gas hydrate reactor is disclosed. The reactor includes an inlet port (510) into which water and gas are supplied, an outlet port (540) disposed opposite the inlet port, a hollow jacket (580) extending from the inlet port to the outlet port, a hollow outer helix (550) installed in the hollow jacket, and an inner helix (560) installed in the outer helix. The gas and water that are supplied into the inlet port react with each other to form gas hydrate in a channel defined between the inner helix and the hollow jacket.Type: GrantFiled: September 19, 2011Date of Patent: January 20, 2015Assignee: Korea Institute of Industrial TechnologyInventors: Ju Dong Lee, Jin Woo Lee, Kyeong Nam Park, Joung Ha Kim
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Patent number: 8936760Abstract: An exhaust gas purification apparatus is provided with: a first soot-accumulation calculation unit 49 which calculates a first soot accumulation amount from an operation state of the engine; a second soot-accumulation calculation unit 51 which calculates a second soot accumulation amount from a total operation time of the engine, a total fuel consumption rate, a pressure difference between front and back of the particulate filter, and the like; a first soot-accumulation correction unit 55 which corrects the first soot accumulation amount calculated by the first soot-accumulation calculation unit 49 to a value greater than the first soot-accumulation amount when the active regeneration starts based on the second soot accumulation amount calculated by the second soot-accumulation calculation unit 51; and a regeneration ending unit 57 which ends the active regeneration when, in such a case that the active regeneration starts based on the corrected soot accumulation amount, the first soot accumulation amount becoType: GrantFiled: January 26, 2011Date of Patent: January 20, 2015Assignee: Mitsubishi Heavy Industries, Ltd.Inventor: Ko Takayanagi
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Patent number: 8936761Abstract: Embodiments of apparatuses and risers for reacting a feedstock in the presence of a catalyst and methods for fabricating such risers are provided. In one example, a riser comprises a sidewall that defines a cylindrical housing surrounding an interior. The sidewall has a groove formed therein disposed about the interior. A plurality of baffle sections is disposed in the groove. The baffle sections are configured to be packed together in the groove to define a packed condition and to be moved in the groove so as to spread out the baffle sections from the packed condition to define an expanded condition and form a baffle ring. The baffle ring extends inwardly in the interior.Type: GrantFiled: August 21, 2013Date of Patent: January 20, 2015Assignee: UOP LLCInventors: Michael S. Sandacz, Robert L. Mehlberg
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Patent number: 8936762Abstract: The present invention relates generally to the field of high content screening of particles, e.g., cells in a flow cytometric system. In particular, the present invention relates to devices, methods and systems to obtain line-scan images of particles, e.g., cells, of a plurality of different samples simultaneously, where the line-scan images can be used to identify cells based on at least one of a variety of phenotypic characteristics such as shape, asymmetry, and intracellular information for cell sorting and selection. In some embodiments, the line-scan images are obtained as the particles, e.g., cells, in a plurality of different samples flow through a plurality of microchannels, reducing the need and time for focusing of the image detection system. In some embodiments, the laser spot size has a small spatial resolution for rapid capturing of images of cells. In some embodiments, the laser spot size has a larger spatial resolution for imaging of larger particles or cells, e.g., rare cells in a sample.Type: GrantFiled: September 1, 2010Date of Patent: January 20, 2015Assignee: Trustees of Boston UniversityInventors: Daniel J. Ehrlich, Brian McKenna
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Patent number: 8936763Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 ?m or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region.Type: GrantFiled: October 22, 2009Date of Patent: January 20, 2015Assignee: Life Technologies CorporationInventors: Jonathan Rothberg, James Bustillo, Mark Milgrew, Jonathan Schultz, David Marran, Todd Rearick, Kim Johnson
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Patent number: 8936764Abstract: The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certain devices include a rotary microfluidic channel and a plurality of temperature regions at different locations along the rotary microfluidic channel at which temperature is regulated. Solution can be repeatedly passed through the temperature regions such that the solution is exposed to different temperatures. Other microfluidic devices include an array of reaction chambers formed by intersecting vertical and horizontal flow channels, with the ability to regulate temperature at the reaction chambers. The microfluidic devices can be used to conduct a number of different analyzes, including various primer extension reactions and nucleic acid amplification reactions.Type: GrantFiled: July 2, 2013Date of Patent: January 20, 2015Assignee: California Institute of TechnologyInventors: Markus M. Enzelberger, Carl L. Hansen, Jian Liu, Stephen R. Quake, Chiem Ma
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Patent number: 8936765Abstract: An automatic analyzer having a reaction vessel in which an analyte is caused to react with a reagent; a probe for suctioning the reacted analyte from the reaction vessel; an analyzer unit for analyzing the reacted analyte; a transfer channel for transferring the reacted analyte suctioned by the probe to the analyzer unit 6; and a liquid-surface detector, connected to the reaction vessel and the probe via signal lines 1a and a pair of signal lines 4a and 4b, respectively, for detecting the electrical characteristics between the probe and the reaction vessel. A switch is located between the signal lines 4a and 4b that connect the liquid-surface detector to the probe, so that the switch can connect or disconnect the signal line 4a to/from the signal line 4b.Type: GrantFiled: February 12, 2010Date of Patent: January 20, 2015Assignee: Hitachi High-Technologies CorporationInventors: Shahed Sarwar, Kazuhiro Tanaka
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Patent number: 8936766Abstract: A lipoaspirate collection device to aid in the collection and processing of human tissue and fluid obtained during liposuction for use in point-of-care cell therapy. The collection device includes a collection body and a collection cap. The collection cap may have a fluid port, a lipoaspirate port, a vacuum port, and a relief valve. Within the central cavity of the collection device, a cone shaped may be positioned such that the apex of the cone is positioned underneath the lipoaspirate inlet through which the lipoaspirate fluid and tissue are introduced.Type: GrantFiled: October 4, 2011Date of Patent: January 20, 2015Assignee: SpineSmith Partners, L.P.Inventors: Ted Sand, Kevin Dunworth, Greg Forman
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Patent number: 8936767Abstract: Disclosed are process and apparatus for vertical splitting of the oxygen supply to a post-oxidation reactor. Further disclosed are process and apparatus for supplying reaction medium to a post-oxidation reactor at a mid-level inlet. Such apparatus and process can assist in reducing oxygen pinch throughout the post-oxidation reactor.Type: GrantFiled: December 1, 2010Date of Patent: January 20, 2015Assignee: Grupo Petrotemex. S.A. DE C.V.Inventors: Ashfaq Shaikh, Alan George Wonders, David Lange
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Patent number: 8936768Abstract: We provide an alkylation process unit, comprising: a control system connected to an alkylation reactor, that enables the alkylation reactor to operate in both an alkylate mode that produces a gasoline blending component having a RON of 90 or higher and in a distillate mode that produces a second gasoline blending component having a RON of 85 or higher.Type: GrantFiled: July 18, 2012Date of Patent: January 20, 2015Assignee: Chevron U.S.A. Inc.Inventors: Hye Kyung Cho Timken, Shawn Shlomo Winter, Howard Steven Lacheen, Sven Ivar Hommeltoft
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Patent number: 8936769Abstract: A system for the production of conversion products from synthesis gas, the system including a mixing apparatus configured for mixing steam with at least one carbonaceous material to produce a reformer feedstock; a reformer configured to produce, from the reformer feedstock, a reformer product comprising synthesis gas comprising hydrogen and carbon monoxide from the reformer feedstock; a synthesis gas conversion apparatus configured to catalytically convert at least a portion of the synthesis gas in the reformer product into synthesis gas conversion product and to separate from the synthesis gas conversion product a tailgas comprising at least one gas selected from the group consisting of carbon monoxide, carbon dioxide, hydrogen and methane; and one or more recycle lines fluidly connecting the synthesis gas conversion apparatus with the mixing apparatus, the reformer, or both.Type: GrantFiled: September 27, 2011Date of Patent: January 20, 2015Assignee: RES USA, LLC.Inventors: Randy Blevins, Joshua B. Pearson, Harold A. Wright
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Patent number: 8936770Abstract: A mineral processing facility is provided that includes a cogen plant to provide electrical energy and waste heat to the facility and an electrochemical acid generation plant to generate, from a salt, a mineral acid for use in recovering valuable metals.Type: GrantFiled: January 20, 2011Date of Patent: January 20, 2015Assignee: Molycorp Minerals, LLCInventor: John L. Burba, III
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Patent number: 8936771Abstract: The invention relates to novel and innovative PCC pigments, able to be used in a paper coating formulations to manufacture coated “multipurpose” papers, in particular for inkjet applications, whose print qualities would be identical or quite similar to high resolution commercial papers, while maintaining a reduced paper manufacturing and production cost. Said pigments are obtained by a carbonation process using a reduced flow rate of CO2/air, which leads to porous agglomerates of PCC of a very specific structure and unique properties, followed by an upconcentration step leading to substantially the same agglomerates but with a higher, appropriate, solids content.Type: GrantFiled: March 29, 2006Date of Patent: January 20, 2015Assignee: Omya International AGInventors: Michael Kaessberger, Michael Pohl
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Patent number: 8936772Abstract: A silica containing composition is disclosed. The silica composition comprising a compound having the following formula (SiO2)x(OH)yMzOaF: wherein M optionally exists and said M is at least one of the following metal or metalloid cations: boron, magnesium, aluminum, calcium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, zirconium, molybdenum, palladium, silver, cadmium, tin, platinum, gold, and bismuth; wherein F optionally exists and said F is at least one of the following: a functionalized organosilane, a sulfur-containing organosilane, an amine-containing organosilane, and an alkyl-containing organosilane at a surface area coverage of 0.01-100%; and wherein the molar ratio of y/x is equal to 0.01-0.5, the molar ratio of x/z is equal to 0.1-300, and the molar ratio of a/z is dependent on the nature of the metal oxide formed.Type: GrantFiled: April 8, 2010Date of Patent: January 20, 2015Assignee: Ecolab USA Inc.Inventors: Bruce A. Keiser, Nicholas S. Ergang, Richard Mimna
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Patent number: 8936773Abstract: Provided herein are compositions, methods, and systems for a material containing metastable carbonate and stabilizer. Methods for making the compositions and using the compositions are also provided.Type: GrantFiled: April 26, 2012Date of Patent: January 20, 2015Assignee: Calera CorporationInventors: Miguel Fernandez, Irvin Chen, Patricia Tung Lee, Matthew Ginder-Vogel
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Patent number: 8936774Abstract: A CVD single crystal diamond material suitable for use in, or as, an optical device or element. It is suitable for use in a wide range of optical applications such as, for example, optical windows, laser windows, optical reflectors, optical refractors and gratings, and etalons. The CVD diamond material is produced by a CVD method in the presence of a controlled low level of nitrogen to control the development of crystal defects and thus achieve a diamond material having key characteristics for optical applications.Type: GrantFiled: January 21, 2010Date of Patent: January 20, 2015Assignee: Element Six Technologies LimitedInventors: Herman Philip Godfried, Geoffrey Alan Scarsbrook, Daniel James Twitchen, Evert Pieter Houwman, Wilhelmus Gertruda Maria Nelissen, Andrew John Whitehead, Clive Edward Hall, Philip Maurice Martineau
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Patent number: 8936775Abstract: The present invention provides novel cathodes having a reduced resistivity and electrochemical cells using these cathodes. Furthermore, this invention also presents methods of manufacturing novel electrochemical cells and novel cathodes.Type: GrantFiled: October 29, 2009Date of Patent: January 20, 2015Assignee: ZPower, LLCInventors: George William Adamson, Hongxia Zhou, Kyunghee Cho
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Patent number: 8936776Abstract: A new family of crystalline microporous metallophosphates designated AlPO-67 has been synthesized. These metallophosphates are represented by the empirical formula R+rMm2+EPxSiyOz where R is an organoammonium cation such as the ETMA+ or DEDMA+, M is a framework metal alkaline earth or transition metal of valence 2+, and E is a trivalent framework element such as aluminum or gallium. The AlPO-67 compositions exhibit the LEV framework topology and have catalytic properties for carrying out various hydrocarbon conversion processes and separation properties for separating at least one component.Type: GrantFiled: November 30, 2012Date of Patent: January 20, 2015Assignee: UOP LLCInventors: Gregory J. Lewis, Lisa M. Knight, Paulina Jakubczak, Justin E. Stanczyk
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Patent number: 8936777Abstract: The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.Type: GrantFiled: February 8, 2011Date of Patent: January 20, 2015Assignee: Lantheus Medical Imaging, Inc.Inventors: Richard R. Cesati, Edward H. Cheesman, Joel Lazewatsky, Heike S. Radeke, Enrico Mongeau, Dianne D. Zdankiewicz, Marybeth Devine
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Patent number: 8936778Abstract: Composition and methods include a dental bleaching agent, potassium nitrate a fluoride salt for enhanced whitening and reduced tooth sensitivity. The potassium nitrate and fluoride salt both reduce or eliminate tooth sensitivity that may otherwise be caused by the bleaching agent. For prolonged treatment of teeth, lower quantities of potassium nitrate (e.g., 0.5%) have actually been found to work better than larger quantities (e.g., 3%). The dental compositions may be applied directly to the person's teeth, or they may be loaded into a comfortable fitting, flexible, thin-walled dental tray and placed over the person's teeth. In that case, the dental compositions will include a tackifying agent, such as carboxypolymethylene, which assists the composition in retaining the dental tray over the person's teeth as a result of the adhesive properties of the dental composition rather than due to mechanical interlocking of the tray over the person's teeth.Type: GrantFiled: April 10, 2007Date of Patent: January 20, 2015Assignee: Ultradent Products, Inc.Inventor: Dan E. Fischer
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Patent number: 8936779Abstract: The present disclosure relates to a cosmetic composition for treating keratin fibers, including human keratin fibers such as the hair, comprising, in a cosmetically acceptable medium, at least one cationic poly(vinyllactam) polymer, at least one fatty alcohol and at least one amino silicone.Type: GrantFiled: December 22, 2006Date of Patent: January 20, 2015Assignee: L'OrealInventors: Dorothee Pasquet, Cecile Bebot
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Patent number: 8936780Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.Type: GrantFiled: August 30, 2006Date of Patent: January 20, 2015Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Gina Zhang, Jessica Renee DesNoyer, Gordon Stewart, Maricela Kezis, Syed Faiyaz Ahmed Hossainy
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Patent number: 8936781Abstract: The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: GrantFiled: April 13, 2010Date of Patent: January 20, 2015Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yonghua Gai, Yat Sun Or, Guoqiang Wang
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Patent number: 8936782Abstract: The present invention describes method of treating bacterial infections, including MRSA. In various embodiments, the methods can use interferon beta, which is found to have antimicrobial activity. In certain embodiments, the interferon beta can be human interferon beta. In other embodiments, the interferon beta can be mouse interferon beta. In further embodiments, the interferon beta can be human interferon beta containing amino acid substitutions to make the human interferon beta more cationic in neutral pH.Type: GrantFiled: November 21, 2012Date of Patent: January 20, 2015Assignee: Cedars-Sinai Medical CenterInventors: David M. Underhill, George Y. Liu, Amber Kaplan
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Patent number: 8936783Abstract: The present technology relates to the use of at least one strain of probiotic bacteria selected from Lactobacillus for the manufacture of a medicament for the treatment and/or prevention of an autoimmune disease.Type: GrantFiled: October 6, 2006Date of Patent: January 20, 2015Assignee: Probi ABInventors: Jan Alenfall, Anna Berggren, Carola Rask, Agnes Wold, Shahram Aghaibeik-Lavasani
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Patent number: 8936784Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.Type: GrantFiled: October 17, 2011Date of Patent: January 20, 2015Assignee: Poly-Med, Inc.Inventors: Joel Corbett, Jason Olbrich, Joanne E. Shalaby
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Patent number: 8936785Abstract: scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable framework matching best the framework of a non-human antibody against the antigen with a certain binding specificity, (ii) either providing said soluble and stable framework with CDRs that bind specifically to said antigen, or mutating the framework of said non-human antibody towards the sequence of said soluble and stable framework, to generate scFv antibodies, (iii) testing the generated antibody for solubility and stability, and testing the generated antibody for antigen binding, and (iv) selecting an scFV that is soluble, stable and binds to the antigen specifically. Also provided are pharmaceutical compositions comprising said scFv antibody, methods of treatment and diagnosis for diseases related to over expression of antigens that are specifically bound by said antibody.Type: GrantFiled: July 10, 2007Date of Patent: January 20, 2015Assignee: Esbatech, An Alcon Biomedical Research Unit, LLCInventors: Adrian Auf Der Maur, Alcide Barberis, David M. Urech, Peter Lichtlen
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Patent number: 8936786Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.Type: GrantFiled: January 8, 2009Date of Patent: January 20, 2015Assignee: Oshadi Drug Administration Ltd.Inventors: Alexander Vol, Orna Gribova
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Patent number: 8936787Abstract: Disclosed herein are peptides and peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate lipoprotein lipase, and compositions comprising such peptides or combinations thereof. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells and activate lipoprotein lipase within cells are also disclosed herein.Type: GrantFiled: April 14, 2009Date of Patent: January 20, 2015Assignee: The United States of America as represented by the Secretary, Department of Health and Human ServicesInventors: Alan T. Remaley, Marcelo J. A. Amar
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Patent number: 8936788Abstract: A method and container for developing seedlings includes germinating the seeds and air pruning the seedlings to a depth of about 3 inches.Type: GrantFiled: June 7, 2013Date of Patent: January 20, 2015Assignee: Wayne Lovelace and Judy LovelaceInventors: Wayne Lovelace, Hugh Steavenson, Bob Suddarth
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Patent number: 8936789Abstract: Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an immunoenhancer that elicit potent and broad HIV neutralizing antibody responses in the immunized hosts. Also disclosed are methods of making and using the immunogenic compositions.Type: GrantFiled: October 16, 2009Date of Patent: January 20, 2015Assignee: New York Bood Center, Inc.Inventors: Shibo Jiang, Zhi Qi, Chungen Pan
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Patent number: 8936790Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.Type: GrantFiled: April 16, 2013Date of Patent: January 20, 2015Assignee: Allergan, Inc.Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
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Patent number: 8936791Abstract: A method for in vitro diagnosis of Staphylococcus aureus producing Panton-Valentine Leukocidin (PVL), using a biological sample derived from an individual liable to be colonized by or infected with Staphylococcus aureus, wherein the diagnosis is carried out by detection of PVL using a routine immunological test, and the biological sample is pretreated in order to denature the PVL.Type: GrantFiled: October 16, 2007Date of Patent: January 20, 2015Assignees: Biomerieux, Intstitut National de la Sante et de la Recherche Medicale (Inserm), Universite Claude Bernard Lyon 1 (UCBL)Inventors: Cedric Badiou, Jerome Etienne, Gerard Lina, Catherine Ratat