Abstract: The present invention provides improved Pseudomonas Exotoxin A (PE) molecules with high cytotoxicity and reduced immunogenicity, compositions containing the improved (PE), and methods of use.

Abstract: Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea. Archaeosome lipid vesicles are formulated from the synthetic lipids selected to serve as antigen carriers that target antigen-presenting cells and promote an appropriate immune response to the antigen.

Abstract: Drug delivery devices, their manufacture, and their use comprising electrocontractile nanotubes that can be used for precise controlled bioactive substance release for example, medical, veterinary, pharmaceutical compounds and growth factors. The conducting polymer nanotubes significantly decrease the impedance and increase the charge capacity of recording electrode sites on microfabricated electrode devices. Bioactive substances released from the nanotubes can be controlled in a desired fashion by controlled electrical stimulation of the nanotubes.

Abstract: A liquid embolic material may include a mixture of a first solution comprising between about 1.2% and about 2.5% weight per volume (w/v) carboxymethyl chitosan (CCN) in a first solvent and a second solution comprising between about 1.2% and about 2.5% w/v oxidized carboxymethyl cellulose (OCMC) in a second solvent. The liquid embolic material may be used to embolize a targeted embolization location by mixing the first solution and the second solution to form a liquid embolic material (or hydrogel precursor material), introducing the hydrogel precursor material to a targeted embolization location within a body of a patient, and allowing the CCN and the OCMC to react to form the hydrogel material and embolize the targeted embolization location.

Abstract: A hair care composition having a conditioning active comprising a sucrose polyester having a melting point greater than about 30° C., an IBAR greater than about 5, an IV of about 3 to about 70, and an aqueous carrier, and may further comprise optional ingredients including but not limited to, silicone, cationic polymers, and fatty alcohols. The composition can also comprise a blend of sucrose polyesters, wherein the blend comprises two or more sucrose polyesters, wherein at least one sucrose polyester has a melting point greater than about 30° C., an IBAR greater than about 5, an IV of about 3 to about 70, and at least one sucrose polyester has an IBAR between about 1 and about 8, and an IV between about 1 and about 135, and wherein the sucrose polyester blend has an IBAR of at least 5 and an IV of about 1 and about 135.

Abstract: The present invention relates to polymer ic thickener compositions comprising at least one water-swellable crosslinked copolymer, a process for preparing such compositions and their use as a thickener, e.g., in cosmetic, dermatologic, pharmaceutical or veterinary formulations. The water-swellable crosslinked copolymer according to the present invention is prepared from a mixture comprising (a) acrylamide, (b) an acrylamidoalkylsulfonic acid and/or a salt thereof and (c) an amine-based polyfunctional crosslinking agent comprising at least three allylic functions.

Abstract: A hair care composition having a conditioning active comprising a sucrose polyester having a melting point greater than about 30° C., an IBAR greater than about 5, an IV of about 3 to about 70, and an aqueous carrier, and may further comprise optional ingredients including but not limited to, silicone, cationic polymers, and fatty alcohols. The composition can also comprise a blend of sucrose polyesters, wherein the blend comprises two or more sucrose polyesters, wherein at least one sucrose polyester has a melting point greater than about 30° C., an IBAR greater than about 5, an IV of about 3 to about 70, and at least one sucrose polyester has an IBAR between about 1 and about 8, and an IV between about 1 and about 135, and wherein the sucrose polyester blend has an IBAR of at least 5 and an IV of about 1 and about 135.

Abstract: The present invention relates to pigments with improved and adjustable sparkling effect comprising A) a plate-like substrate of perlite coated with (a) dielectric material, and/or metal; and B) a plate-like substrate of mica, coated with (a) dielectric material, and/or a metal; and a process for their production and their use in paints, ink jet printing, for dyeing textiles, for pigmenting coatings (paints), printing inks, plastics, cosmetics, glazes for ceramics and glass. The pigments show an improved sparkle effect; in particular an attractive high sparkle intensity.

Abstract: Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° C. and 40° C.

Abstract: By incorporating PBO and phtalocyanine in a polymeric matrix, the surface concentration of the PBO after migration to the surface is reduced relatively to a matrix without phtalocyanine. This can be used to control the migration of PBO and retain PBO for a long-lasting effect.

Abstract: The present invention relates to a molded article which is shaped of a polymer composition comprising 100 parts by weight of an olefin-based polymer, and 0.01 to 100 parts by weight of a C10-90 saturated chain hydrocarbon and/or liquid paraffin and 0.01 to 200 parts by weight of a releasable active compound per 100 parts by weight of said olefin-based polymer, and which is drawn at a draw ratio of 2 or more.

Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, and/or 15-HETrE, used singly or in combination for the prevention and/or treatment of effects associated with UV radiation such as erythema.

Abstract: This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.

Abstract: A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding hydroxyapatite (HAP) nanoparticles to form a uniformly distributed mixture, applying the mixture to a polytetrafluoroethylene (PTFE) surface to form a polymer film, cutting the polymer film into strips, stacking the strips with layers of bone particles disposed therebetween, coating the stacked strips and layers by the mixture and allowing it to dry, adding bone particles to the coating, and plasma treating the structure to form the biocompatible structure. A weight percentage of the HAP nanoparticles to the polymer is about 5-50% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.

Abstract: The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes. The invention can be used to slow, reduce, or prevent the onset of cardiac damage caused by, for example, myocardial ischemia, hypoxia, stroke, or myocardial infarction in vivo. In addition, the methods and compositions of the invention can be used to enhance proliferation of differentiated cardiomyocytes in vitro and/or ex vivo, which can then be used in tissue grafting.

Abstract: Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.

Abstract: The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.

Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.

Abstract: Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate.

Abstract: Disclosed is a substantially non-releasable form of an opioid antagonist containing the opioid antagonist combined with one or more pharmaceutically acceptable hydrophobic material(s) such that the antagonist is not released or substantially not released during its transit through the gastrointestinal tract when administered orally in an intact oral dosage form. Oral dosage forms containing an opioid agonist and a substantially non-releasable form of an opioid antagonist are also disclosed.

Abstract: A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.

Abstract: A topical composition is provided. The topical composition comprises from about 0.25 to about 1.5 percent by weight hydrocortisone; from about 0.5 to about 5.0 percent by weight lidocaine; and from about 0.25 to about 3.0 percent by weight clotrimazole.

Abstract: The therapeutic device is an acupuncture device which is usable for treating chronic, but non-contagious diseases. The device is in the form of a solid chip or tablet having a unique composition, which can be placed on the body of a patient's acupuncture meridian points for the treatment. The treatment with this device is safe, more effective, non-invasive and easy to use over other alternative treatments because it does not involve the use of needles, medication, electricity and radiation.

Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of collagen, porous collagen or a collagen mixture. Preferably, the carrier material is exclusively collagen.

Abstract: Gymnema sylvestre extracts together with extracts of one or more of Boswellia serrata, Tinospora cordifolia and Commiphora mukul provide effective weight loss management when administered to a patient desiring weight loss management. Administration of the foregoing also reduces the leptin-to-adiponectin ratio in the patient's blood serum.

Abstract: A pomegranate beverage including a pomegranate juice component prepared by crushing and squeezing whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component, where the juice component separated from the insoluble by-product component to obtain the pomegranate juice component, and an amount of a pomegranate extract component including at least 30 to 3000 ?mols of polyphenols, where the beverage is prepared by a process including re-suspending the insoluble by-product component in an aqueous medium, mixing the re-suspended insoluble by-product component and the aqueous medium, and separating an aqueous extract from the insoluble by-product component to obtain the pomegranate extract component, where the aqueous extract includes polyphenols resulting from the insoluble by-product component.

Abstract: A receptacle holding unit (1) for a device for preparing a beverage from an ingredient contained in a receptacle (2) having: —a first part (10); —a second part (20) that is movable towards the first part, in particular along a longitudinal axis (1?), into a closed position for holding the receptacle in such unit and relatively apart from the first part into an open position for inserting the receptacle into such unit and/or for removal therefrom; —a fastening device (11, 21) having a fastened configuration for fastening together the first and second parts (10, 20) in the closed position and an unfastened configuration such to enable movement of the first and second parts out of the closed configuration; and —an actuator (30) movable between an open configuration and a closed configuration to drive the first part and the second part between the open and the closed positions.

Abstract: Batch process for the manufacture of oxidized starch by contacting an aqueous medium comprising already oxidized starch with native starch and with at least one oxidizing agent selected from a peroxide compound or from an alkali metal hypochlorite, and by reacting them at a temperature below the gelatinization temperature of the native starch and of the oxidized starch, the reaction being conducted in the presence of a homogeneous manganese-based complex coordination catalyst when the oxidizing agent is a peroxide compound. The resulting oxidized starch can be used as an additive for the paper industry or for the food industry.

Abstract: The present invention relates to frozen aerated products including products manufactured by low-temperature extrusion with superior creaminess. In particular, the invention is concerned with a partially coagulated protein system induced by controlled coagulation of milk protein which imparts outstanding sensory attributes on frozen confectionery including low-temperature extruded frozen products, in particular when containing low fat. A method of producing such frozen aerated confectionery product and the products obtainable from the method are also part of the present invention.

Abstract: The present invention relates to a process for manufacturing an animal feed or a foodstuff, comprising the steps of (i) preparing at least one first stream of material and at least one second stream of material, (ii) dispersing the second stream of material in the first stream of material in a laminar fashion in a device for at least partially incompletely blending the first and second streams of material, so that the second stream of material is distributed in the first stream of material preferably in the form of droplets ranging in size from 0.3 mm to 8 mm, (iii) discharging the first stream of material containing the second stream of material in the form of droplets through a nozzle, and (iv) solidifying the first stream of material containing the second stream of material in the form of droplets.

Abstract: The present invention has as an objective to provide an emulsion for shallow flying which has reduced spattering. This objective has been met by an emulsion which contains ethylcellulose particles.

Abstract: A soy protein product having a protein content of at least about 60 wt % (N×6.25) d.b., preferably an isolate having a protein content of at least about 90 wt % (N×6.25) d.b., is formed by extracting a soy protein source with a salt solution, preferably aqueous sodium chloride solution, to form an aqueous protein solution having a pH of about 1.5 to 11, preferably about 5 to about 7 and separating the resulting aqueous protein solution from residual soy protein source. The protein concentration of the aqueous protein solution is increased to about 50 to about 400 g/L while the ionic strength is maintained substantially constant by using a selective membrane technique. The resulting concentrated protein solution is optionally diafiltered and a calcium salt, preferably calcium chloride, is added to the concentrated and optionally diafiltered protein solution to a conductivity of 15 to about 85 mS.

Abstract: The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.

Abstract: A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer.

Abstract: A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and wherein at a temperature of 30° C. and at one atmosphere, the composition may be in a solid state or semi-solid state.

Abstract: Provided is a method of fabricating a substrate where patterns are formed, the method including: preparing a solution in which a plurality of oxide beads are dispersed; forming patterns on a substrate; installing a provisional structure in an upper portion of the substrate so that a micro-channel is formed on the substrate; injecting the solution in which the oxide beads are dispersed, into the micro-channel and fixing the oxide beads at the substrate; and thermally processing the substrate. A plurality of low-priced oxide beads can be patterned on a substrate to have a desired shape so that damages can be prevented from occurring in the substrate during dry etching, and an etching process is not performed so that a yield of a device is not reduced and mass production of the device increases.

Abstract: Functional groups on the outermost surface of an amorphous hydrocarbon film are substituted. The amorphous hydrocarbon film is formed on a silicon substrate Sub, which is coated with a low-k film. A heat treatment is performed on the amorphous hydrocarbon film in a non-silane gas atmosphere. Next, a heat treatment is performed on the amorphous hydrocarbon film in a silane gas atmosphere immediately after the heat treatment in a non-silane gas atmosphere. After the heat treatment, a film, such as a hard mask, is formed.

Abstract: The present invention relates to a method and an apparatus by which powder is evenly dispersed and is coated on a substrate uniformly and continuously so that a uniform layer may be formed. More specifically the present invention provides a method and an apparatus for forming a coating layer that powder is coated on an entire surface of a substrate uniformly and continuously, regardless of the material or the size of the substrate, as a uniform amount of powder entrained on the carrier air which is generated by carrier air and powder transported to a carrier pipe at a certain rate is consistently fed in to a nozzle, regardless of the size, morphology, and specific weight of the powder particles.

Abstract: The invention provides a method for dispersing particles within a reaction field, the method comprising confining the particles to the reaction field using a standing wave. The invention also provides a system for coating particles, the system comprising a reaction zone; a means for producing fluidized particles within the reaction zone; a fluid to produce a standing wave within the reaction zone; and a means for introducing coating moieties to the reaction zone. The invention also provides a method for coating particles, the method comprising fluidizing the particles, subjecting the particles to a standing wave; and contacting the subjected particles with a coating moiety.

Abstract: A method for wet treatment of plate-like articles includes, a chuck for holding a single plate-like article having an upwardly facing surface for receiving liquid running off a plate-like article when being treated with liquid, wherein the chuck is outwardly bordered by a circumferential annular lip. The chuck has an outer diameter greater than the greatest diameter of the plate-like article to be treated, and a rotatable part with an upwardly facing ring-shaped surface for receiving liquid running off the circumferential lip of the chuck. The rotatable part is rotatable with respect to the chuck, the ring-shaped surface is coaxially arranged with respect to the circumferential annular lip, the inner diameter of the ring-shaped surface is smaller than the outer diameter of the chuck, and the distance d between the lip and the upwardly facing ring-shaped surface is in a range from 0.1 mm to 5 mm.

Abstract: Three dimensional anti-reflection porous films or coated substrates and method for forming the films or coated substrates are disclosed, where the films or coatings have optical transmittances of at least 86% or a reflectance of at most 4%. The 3D anti-reflection porous film or coating compositions (a) one polymer or a plurality of network polymers, (b) one particles and/or a plurality particles, (c) optionally one crosslinking agent or a plurality of crosslinking agents, (d) optionally one oligomer or a plurality of oligomers, (e) optionally one polymerized monomer or a plurality of polymerized monomers, and (f) optionally void spaces, where the composition has a transmittance value of at least 86% or a reflectance value of at most 4%.

Abstract: Novel methods and apparatuses for annealing semiconductor devices in a high pressure gas environment. According to an embodiment, the annealing vessel has a dual chamber structure, and potentially toxic, flammable, or otherwise reactive gas is confined in an inner chamber which is protected by pressures of inert gas contained in the outer chamber. The incoming gas delivery system and exhaust gas venting system are likewise protected by various methods. Embodiments of the present invention can be used, for example, for high-K gate dielectric anneal, post metallization sintering anneal, and forming gas anneal in the semiconductor manufacturing process.

Abstract: A mixture of an elastomer, carbon black, and inorganic fillers provides a highly useful laser-ablatable flexographic printing plate precursor formulation. This formulation is sensitive to infrared radiation. Both flexographic printing plates and printing sleeves can be made using the mixture.

Abstract: A process for coating a metallic surface with an aqueous composition containing a) as the main component, an organic film former consisting of at least one synthetic resin, 70 to 100 wt. % of the content of synthetic resin(s) in the organic film former comprising at least one water-soluble or/and water-dispersible synthetic resin in the form of polymers, copolymers, block copolymers or/and graft copolymers based on synthetic resins selected from the group consisting of polycarbonate, polyurethane, ionomer, poly(meth)acrylate, polyester, polyether or/and polystyrene, the content of polycarbonate and polyurethane being at least 10 wt. % each, at least one long-chain alcohol as film-forming aid for the organic film former, a crosslinker, a lubricant, and a substance based on silane, silanol or/and siloxane or/and at least one inorganic compound in particle form with an average particle diameter measured on a scanning electron microscope in the range from 0.005 to 0.

Abstract: The method includes: forming a coating film including particles and an ultraviolet curable resin on a film substrate; and curing the ultraviolet curable resin by ultraviolet irradiation to form an anti-glare layer constituted by the particles and the ultraviolet curable resin. A ratio of a thickness A of the anti-glare layer to a diameter B of the particles is in the range of 1.5 to 2.4. The ultraviolet irradiation is performed with two or more ultraviolet irradiation units, the first unit irradiation amount is 49 mJ/cm2 or less, the second and subsequent units irradiation amount is greater than 50 mJ/cm2, and the total irradiation amount is 100 mJ/cm2 or greater. The oxygen concentration at a position which is 1 mm above a surface of the coating film is 1 ppm to 2000 ppm. The first unit irradiation is performed above a roller with surface temperature of 10° C. to 24° C.

Abstract: The present disclosure is directed to a method for coating the edge of glass articles. The shaped edge of a glass article is inserted into the slot of a coating apparatus. The coating apparatus includes a vessel containing a UV curable coating material, an element connected to the vessel having the slot, wherein the slot is shaped to receive an edge of the glass article; and a coating pad having a coating surface shaped to conform to the shaped edge of the glass article, the pad having a network of interconnected openings therethrough, wherein the coating pad extends from the vessel and into the element so that the coating surface forms a bottom surface of the slot. An ultraviolet (UV) curable coating material is supplied to the coating pad and the shaped edge is contacted with the coating pad surface to transfer a selected thickness of the coating material from the coating pad to the shaped edge. The UV curable coating material is then cured on the shaped glass edge.

Abstract: The present invention provides a display panel with a flat plate in which a member partially provided with a light blocking part is disposed in front of a display panel, and a curable resin therebetween is sufficiently cured even in an area behind the light blocking part. The display panel with a flat plate of the present invention includes: a flat plate provided with a light passing part and a light blocking part; a display panel; and an adhesive layer between the flat plate and the display panel, the adhesive layer being a cured resin layer obtainable by polymerization involving at least one reactive component selected from the group consisting of a (meth)acrylate oligomer, a bicyclic ring-containing (meth)acrylate monomer, and a hydroxyl group-containing (meth)acrylate monomer, a peroxide component, and a primer as reaction materials.

Abstract: The purpose of the present invention is to provide a retardation film which has high retardation developability, good mechanical strength and good durability. This retardation film contains a cellulose derivative and at least one compound represented by general formula (1), wherein each of R1 and R2 independently represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group; X1 represents a single bond, —NR4—, —O— or —S—; X2 represents a single bond, —NR5—, —NR5—(C?O)—, —O— or —S—; each of R4 and R5 independently represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group; R3 represents a substituent; n represents an integer of 0-4; and when n is 2 or more, a plurality of R3s may be the same or different and adjacent R3s may be joined together to form a ring).

Abstract: A thermal transfer printable multilayer label tape for identifying fluid lines, the tape comprising: (A) A clear topcoat layer; (B) A clear first primer layer in contact with the topcoat layer; (C) A clear face sheet layer in contact with the first primer layer; (D) A clear second primer layer in contact with the face sheet layer; (E) A color layer in contact with the second primer layer; and (F) An adhesive layer in contact with the color layer.