Patents Issued in January 29, 2015
  • USE OF NEW RECOMBINANT INTERFERONS WITH ALTERED SPATIAL CONFIGURATION AND THREE-DIMENSIONAL STRUCTURE
    Publication number: 20150031859
    Abstract: This invention provides a crystalline recombinant interferon (rSIFN-co) having (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered three-dimensional structure as compared to IFN-?2b. The interferon of the present invention exhibits enhanced biological activities. The present invention also provides a structure model of said interferon useful for drug screening and/or drug design and the mimetic of said interferon. The invention further provides methods of designing and using new recombinant interferons with altered spatial configuration and three-dimensional structure.
    Type: Application
    Filed: September 26, 2014
    Publication date: January 29, 2015
    Inventor: GUANGWEN WEI
  • HUMAN ANTIBODIES AND PROTEINS
    Publication number: 20150031860
    Abstract: The present invention provides composite proteins, including antibodies, which show reduced immunogenicity. In particular, composite antibodies for use in humans are provided, in particular antibodies which have been modified to remove one or more T-cell epitopes. Methods for generating such proteins are also provided.
    Type: Application
    Filed: July 7, 2014
    Publication date: January 29, 2015
    Inventors: Timothy David Jones, Matthew Paul Baker
  • Chemical Modification of Antibodies
    Publication number: 20150031861
    Abstract: The present invention relates to antibodies and antibody fragments, one or more of whose native inter-chain disulfide bridges have been replaced with a specific bridging moiety. The bridging moiety can be selectively targeted to inter-chain disulfide bonds within the antibody or antibody fragment, enabling the construction of more homogenously modified products such as antibody-drug conjugates.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 29, 2015
    Inventors: Mark Smith, James Baker, Felix Schumacher, Stephen Caddick, Vijay Chudasama, Antoine Maruani
  • OPTIMIZED Fc VARIANTS
    Publication number: 20150031862
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 29, 2015
    Inventors: Gregory LAZAR, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes, Jost Vielmetter
  • CONJUGATING AMINES
    Publication number: 20150031863
    Abstract: The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 29, 2015
    Applicant: The General Hospital Corporation
    Inventors: Edward T. Ryan, Pavol Kovac, Firdausi Qadri, Peng Xu, Stephen B. Calderwood, Willie Frank Vann, Dwight Christopher Peterson
  • Modified Adiponectin Polypeptides and Their Uses
    Publication number: 20150031864
    Abstract: Modified adiponectin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 27, 2013
    Publication date: January 29, 2015
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Putnam
  • PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
    Publication number: 20150031865
    Abstract: The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 29, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
    Publication number: 20150031866
    Abstract: The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 29, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • WATER-SOLUBLE FLUORESCENCE COMPOUND AND METHOD FOR PREPARING THE SAME
    Publication number: 20150031867
    Abstract: The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-?-glucoside [(E)-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Formula 1 which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-?-glucoside and its derivatives of having Formula 3 which are not fluorescent. Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).
    Type: Application
    Filed: September 5, 2012
    Publication date: January 29, 2015
    Inventors: Seong Keun Kim, Seung Yang, Seon JIn Hwang, Jung Eun Lee, Jong Woo Lee, Jun Hee Kang, Eun Hak Lim
  • DITERPENE PRODUCTION
    Publication number: 20150031868
    Abstract: The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.
    Type: Application
    Filed: January 23, 2013
    Publication date: January 29, 2015
    Inventors: Martin Lehmann, Joshua Trueheart, Priscilla Zwart Jens, Liang Wu, Viktor Marius Boer, Cornelis Maria Jacobus Sagt, Manoj Kumar, Bernard Meijrink, Marco Alexander Van Den Berg
  • HIGH-PURITY STEVIOL GLYCOSIDES
    Publication number: 20150031869
    Abstract: Methods of preparing highly purified steviol glycosides, particularly rebaudiosides A, D and X are described. The method includes expression of UDP-glucosyltransferases from Stevia rebaudiana Bertoni, which are capable converting certain steviol glycosides to rebaudiosides A, D and X. The highly purified rebaudiosides A, D and X, are useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
    Type: Application
    Filed: August 26, 2014
    Publication date: January 29, 2015
    Inventors: Avetik MARKOSYAN, Cyrille JARRIN, Patrick ROBE, Rob ter HALLE, Indra PRAKASH, Venkata Sai PRAKASH CHATURVEDULA
  • ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Publication number: 20150031870
    Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 29, 2015
    Inventors: SIMON MARK JACKSON, Nigel Pelham Clinton Walker, Derek Evan Piper, Wenyan Shen, Chadwick Terence King, Randal Robert Ketchem, Christopher Mehlin, Teresa Arazas Carabeo
  • RNA-Mediated Gene Modulation
    Publication number: 20150031871
    Abstract: An isolated RNA comprising an intron RNA that is released in a cell, thereby modulating the function of a target gene. Also disclosed are a composition comprising a chemokine and an isolated RNA of the invention or a DNA template for the isolated RNA, a composition comprising one or more agents that induce RNA-mediated modulation of the functions of two or more target genes in a cell, and methods of using these compositions for modulating the functions of genes in a cell.
    Type: Application
    Filed: November 19, 2013
    Publication date: January 29, 2015
    Applicant: University of Southern California
    Inventors: Shi-Lung LIN, Shao-Yao YING
  • METHOD FOR SCREENING ANTICANCER DRUGS, AND ANTICANCER DRUG THAT INDUCES CELL DEATH AND USES SUBSTANCE THAT INCREASES GRANZYME M ACTIVITY AS ACTIVE INGREDIENT
    Publication number: 20150031872
    Abstract: The purpose of the present invention is to provide a method for screening anticancer drugs that use novel treatment mechanisms, and an anticancer drug that induces cell death and uses a substance that increases the activity of granzyme M as an active ingredient. This method for screening anticancer drugs comprises: a step for administering test substances to cancer cells; a step for detecting the activity of granzyme M in which cancer cells are expressed, and selecting test substances for which an increase in activity has been verified; and/or a step for detecting the presence or absence of cancer cell death induced by the activation of granzyme M in which cancer cells are expressed, and selecting test substances for which cell death has been verified.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 29, 2015
    Inventors: Shunichiro Kubota, Motohiko Sato, Liyun Wang
  • PROCESS OF PREPARING AN ESTER OF A CELLULOSE ETHER
    Publication number: 20150031873
    Abstract: A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic mono-carboxylic acid anhydride and a di- or tri-carboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s?1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 29, 2015
    Applicant: Dow Global Technologies LLC
    Inventors: Matthias Sprehe, Oliver Petermann, Robert Bruce Appell
  • MALTOSE ENRICHED PRODUCTS
    Publication number: 20150031874
    Abstract: The present invention relates to a process for producing a syrup which is rich in maltose. The process is comprising the successive steps of liquefaction of a starch milk and saccharification of the liquefied starch milk in the presence of alpha-amylase, beta-amylase and a debranching enzyme selected from the group of pullulanase, iso-amylase and mixtures thereof, preferably pullulanase and further adding maltogenic alpha-amylase and/or iso-amylase, for obtaining a maltose containing syrup comprising at least 85% maltose based on dry matter and less than 1.5% glucose based on dry matter, preferably less than 1% glucose based on dry matter.
    Type: Application
    Filed: January 24, 2013
    Publication date: January 29, 2015
    Applicant: Cargill, Incorporated
    Inventors: Tiziano Furlan, Luigi Nataloni, Patrizia Tolomelli
  • COMBINED SYNTHESIS ROUTE FOR DESOGESTREL AND ETONOGESTREL
    Publication number: 20150031875
    Abstract: The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 29, 2015
    Inventor: Martin Ostendorf
  • METHOD FOR PRODUCING PYRONE AND PYRIDONE DERIVATIVES
    Publication number: 20150031876
    Abstract: The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same.
    Type: Application
    Filed: September 5, 2014
    Publication date: January 29, 2015
    Applicant: Shionogi & Co., Ltd.
    Inventors: Yukihito Sumino, Kazuya Okamoto, Moriyasu Masui, Toshiyuki Akiyama
  • CRYSTAL OF FLUMIOXAZIN
    Publication number: 20150031877
    Abstract: A crystal of flumioxazin, which shows a powder X-Ray diffraction pattern having diffraction peaks with 2? values (°) shown in Table. TABLE 2? value (°) ?9.8 ± 0.1 11.4 ± 0.1 12.7 ± 0.1 13.8 ± 0.1 16.0 ± 0.1 16.4 ± 0.1 16.7 ± 0.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 29, 2015
    Inventor: Mitsunori Hiratsuka
  • DERIVATIVES OF DOCOSAHEXAENOYLETHANOLAMIDE AND USES THEREOF
    Publication number: 20150031878
    Abstract: The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as methods of using these derivatives to promote neurogenesis, neurite growth and/or length, and/or promote synaptogenesis.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 29, 2015
    Inventors: Hee-Yong Kim, Juan Jose Marugan, Erika E. Englund, Samarjit Patnaik
  • PROCESS FOR THE SYNTHESIS OF N-ALKOXYAMINES
    Publication number: 20150031879
    Abstract: The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.
    Type: Application
    Filed: October 14, 2014
    Publication date: January 29, 2015
    Applicant: BASF SE
    Inventors: Markus FREY, Valerie Rast, Francisco Martinez, Davide Alvisi
  • CDK Inhibitors
    Publication number: 20150031880
    Abstract: Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
    Type: Application
    Filed: August 5, 2014
    Publication date: January 29, 2015
    Inventors: Francis X. Tavares, Jay C. Strum
  • PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20150031881
    Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
    Type: Application
    Filed: February 21, 2014
    Publication date: January 29, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
  • METHODS FOR TREATING CANCER USING PI3K INHIBITOR AND MEK INHIBITOR
    Publication number: 20150031882
    Abstract: Methods of treating patients with cancer are provided, wherein the methods comprise administering to the patient an effective amount of a MEK inhibitor and an effective amount of a PI3K inhibitor. Compositions in which the MEK and PI3K inhibitors are combined also are described.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 29, 2015
    Inventors: Karl HSU, Joanne LAGER, Janet OGDEN
  • 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE-CARBALDEHYDES, AND METHODS OF FORMATION AND USE
    Publication number: 20150031883
    Abstract: 2,6-Dihalo-5-alkoxy-4-substituted-pyrimidines, 2,6-dihalo-5-alkoxy-4-pyrimdine carbaldehydes, and derivatives of each are useful intermediates in forming potent herbicides that demonstrate a broad spectrum of weed control. These compounds are disclosed, as are methods of forming and using these compounds.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 29, 2015
    Inventors: Thomas Lyman Siddall, Joshua John Roth
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20150031884
    Abstract: The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.
    Type: Application
    Filed: December 15, 2011
    Publication date: January 29, 2015
    Applicant: ABBVIE INC.
    Inventors: Allan C. Krueger, Warren M. Kati, Clarence J. Maring, Rolf Wagner, Charles W. Hutchins
  • MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE
    Publication number: 20150031885
    Abstract: A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 29, 2015
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Keiko TAKAKURA, Namika NAKAMATSU, Sakiko TAKESHIMA, Takayoshi NAKASHIMA
  • ALKALINE EARTH METAL-COMPLEXED METAL AMIDES
    Publication number: 20150031886
    Abstract: The present invention relates to metal amides of the formula (I), to a process for preparation thereof and to the use thereof as bases for aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated C—H bonds.
    Type: Application
    Filed: February 13, 2013
    Publication date: January 29, 2015
    Inventors: Mark James Ford, Marc Mosrin
  • 9-AZANORADAMANTANE N-OXYL COMPOUND AND METHOD FOR PRODUCING SAME, AND ORGANIC OXIDATION CATALYST AND METHOD FOR OXIDIZING ALCOHOLS USING 9-AZANORADAMANTANE N-OXYL COMPOUND
    Publication number: 20150031887
    Abstract: An organocatalyst for oxidizing alcohols in which a primary alcohol is selectively oxidized in a polyol substrate having a plurality of alcohols under environmentally-friendly conditions. The organic oxidation catalyst has an oxygen atom bonded to a nitrogen atom of an azanoradamantane skeleton and at least one alkyl group at positions 1 and 5. The oxidation catalyst has higher activity than TEMPO, which is an existing oxidation catalyst, in the selective oxidation reaction of primary alcohols, and better selectivity than AZADO and 1-Me-AZADO. This DMN-AZADO can be applied to the selective oxidation reaction of primary alcohols that contributes to shortening the synthesizing process for pharmaceuticals, pharmaceutical raw materials, agricultural chemicals, cosmetics, organic materials, and other such high value-added organic compounds.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 29, 2015
    Inventors: Yoshiharu Iwabuchi, Masatoshi Shibuya, Ryusuke Doi
  • PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE
    Publication number: 20150031888
    Abstract: The invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R2, R3 and R4 are as defined in the specification, comprising the steps of a) catalytic asymmetric hydrogenation of an enamine of the formula wherein R1 is lower alkyl, in the presence of a transition metal catalyst containing a chiral diphosphane ligand, b) introduction of an amino protecting group Prot and c) amidation of the ester to form an amide of formula wherein R2, R3, R4 and Prot are as defined in the specification.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 29, 2015
    Inventors: Stefan Abrecht, Michelangelo Scalone, Rudolf Schmid
  • ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
    Publication number: 20150031889
    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent, an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
    Type: Application
    Filed: August 14, 2014
    Publication date: January 29, 2015
    Inventors: Brij Pal Giri, Dinesh J. Dagli, Pritam Singh
  • PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC PYRIDINOL DERIVATIVES FOR PREVENTING OR TREATING DISEASES CAUSED BY ANGIOGENESIS
    Publication number: 20150031890
    Abstract: There is provided a pharmaceutical composition comprising a bicyclic pyridinol derivative as an active ingredient for preventing or treating diseases caused by angiogenesis. The bicyclic pyridinol derivative expressed by Chemical Formula 1 can be effectively used as a drug for preventing and treating diseases caused by angiogenesis since it inhibits neovascularization in a chorioallantoic membrane model.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 29, 2015
    Inventors: Byeong Seon Jeong, Jung Ae Kim, You Ra Kang, Tae Gyu Nam, Jin Mo Ku, Ned A. Porter
  • BIS-QUARTERNARY CINCHONA ALKALOID SALTS AS ASYMMETRIC PHASE TRANSFER CATALYSTS
    Publication number: 20150031891
    Abstract: The invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. The present invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. On certain substrates and under specific reaction conditions, the inventors have discovered that the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis surprisingly provides for a more active and efficient process as compared to mono-quarternary catalysts.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 29, 2015
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Bangping Xiang, Nobuyoshi Yasuda
  • SPHINGOLIPID METABOLITE MIMETICS
    Publication number: 20150031892
    Abstract: Sphingolipid metabolite mimetics and methods of synthesizing them are provided. The sphingolipid metabolite mimetics are shown to be effective at inducing apoptosis in various types of tumor cells. Further, the sphingolipid metabolite mimetics are shown to be effective at sensitizing multiple types of tumor cells to TRAIL-induced apoptosis. Formulations containing one or more sphingolipid metabolite mimetics and, optionally, one or more cell death receptor agonists are provided. Methods of treating cancer in a subject in need thereof are provided using one or more sphingolipid metabolite mimetics.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: Feiyan Liu, Kebin Liu, Zhizhen Huang, Ping Wu
  • AN H3 RECEPTOR ANTAGONIST FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20150031893
    Abstract: This disclosure relates to methods of using 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide in a disease modifying therapy of Alzheimer's disease, other tauopathies and related neurodegenerative diseases.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 29, 2015
    Inventors: Pascal BARNEOUD, Veronique BLANCHARD-BREGEON, Veronique MARY, Jean MENAGER, Philippe DELAY-GOYET, Mathilde LOPEZ GRANCHA, Thomas ROONEY, Nathalie SCHUSSLER
  • NOVEL ORGANIC COMPOUND
    Publication number: 20150031894
    Abstract: The present invention provides an organic compound to be used in an electrochromic device. The organic compound has excellent oxidation-reduction repeating characteristics and shows high transparency in the bleached state without showing light absorption in the visible light region. The organic compound has a structure represented by Formula [1] according to Claim 1. In Formula [1], A1 and A2 represent substituents, and at least one of A1 and A2 is an alkyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, or an optionally substituted aryl group. R1 represents a substituent, X represents an electrochromic portion, and n is an integer of 1 to 3.
    Type: Application
    Filed: November 26, 2012
    Publication date: January 29, 2015
    Inventors: Kenji Yamada, Shinjiro Okada
  • COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES
    Publication number: 20150031895
    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion in human blood plasma to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt, Cu(II) ion in the presence of a reducing agent, or copper metal.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 29, 2015
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: K. Barry SHARPLESS, Valery FOKIN, Vsevold A. ROSTOVTSEV, Luke GREEN, Fahmi HIMO
  • COMPOUNDS FOR ORGANIC ELECTRONIC DEVICES
    Publication number: 20150031896
    Abstract: The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 29, 2015
    Inventors: Horst Vestweber, Holger Heil, Philipp Stoessel, Arne Buesing, Amir Hossain Parham, Rocco Fortte
  • COMBINED ACETYLCHOLINESTERASE INHIBITOR AND QUATERNARY AMMONIUM ANTIMUSCARINIC THERAPY TO ALTER PROGRESSION OF COGNITIVE DISEASES
    Publication number: 20150031897
    Abstract: A method administers quaternary ammonium anti-cholinergic muscarinic receptor antagonists in combination with acetyl-cholinesterase inhibitors to treat either cognitive impairment or acute delirium. This therapy results in a modification of a cognitive disorder or disease, namely a slow down in the disease progression. In one preferred embodiment, the disease is dementia with Lewy Bodies. New formulations for quaternary ammonium anti-cholinergic muscarinic receptor antagonists are also disclosed.
    Type: Application
    Filed: October 14, 2014
    Publication date: January 29, 2015
    Inventor: Steven A. Rich
  • PROCESS FOR PREPARATION OF PROSTAGLANDIN F2 ALPHA ANALOGUES
    Publication number: 20150031898
    Abstract: A convergent synthesis of the prostaglandin F2? analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ?-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 29, 2015
    Applicant: INSTYTUT FARMACEUTYCZNY
    Inventors: Iwona Dams, Andrzej Kutner, Michal Chodynski, Malgorzata Krupa, Anita Pietraszek, Marta Zezula, Piotr Cmoch, Monika Kosinska
  • CUCN-MEDIATED ONE POT PRODUCTION OF CINNAMONITRILE DERIVATIVES
    Publication number: 20150031899
    Abstract: The present invention discloses a cheaper and practical protocol for the construction of a wide variety of o-cyanocin-namonitrile and their structural analogues that proceeds with good yields in a single step using CuCN as the only reagent.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 29, 2015
    Inventors: Brij Bhushan Ahuja, Reddy Santosh Rekula, Arumugam Sudalai
  • Organic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Appliance, and Lighting Device
    Publication number: 20150031900
    Abstract: An organic compound that emits blue light with high color purity and has a long lifetime is provided as a novel substance. The organic compound is a fluorescent organic compound having a structure in which benzonaphthofuranylamine is bonded to the 1-position and the 6-position of a pyrene skeleton.
    Type: Application
    Filed: July 23, 2014
    Publication date: January 29, 2015
    Inventors: Sachiko KAWAKAMI, Naoaki HASHIMOTO, Tsunenori SUZUKI, Satoshi SEO
  • METHOD FOR PREPARING 5-AMINO-BENZOFURAN DERIVATIVES
    Publication number: 20150031901
    Abstract: The invention relates to a method for preparing 5-amino-benzoyl-benzofuran derivatives having the general formula in which R1 is hydrogen or an alkyl or aryl group and R2 is hydrogen, an alkyl, alkoxy or dialkylaminoalkoxy group. According to the invention, the compounds having formula I are prepared by hydrogenating a 5-nitro-benzofuran derivative having the general formula in which R1 and R2 have the same meaning as above in the presence of palladised charcoal as a catalyst and in an ether or a mixture of ether as a solvent, thus forming the desired compounds.
    Type: Application
    Filed: November 28, 2012
    Publication date: January 29, 2015
    Applicant: SANOFI
    Inventors: Xavier Bon, Jean-Louis Delepine, Laure Jourdin, Denis Largeau, Philippe Vayron
  • PROCESS FOR THE PREPARATION OF DRONEDARONE BY OXIDATION OF A SULPHENYL GROUP
    Publication number: 20150031902
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 29, 2015
    Applicant: SANOFI
    Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
  • ESTERIFICATION OF FURAN-2,5-DICARBOXYLIC ACID TO A DIALKYL-FURAN-2,5-DICARBOXYLATE VAPOR WITH RECTIFICATION
    Publication number: 20150031903
    Abstract: A process for the manufacture of dialkyl furan-2,5-dicarboxylate (DAFD) vapor composition by feeding furan-2,5-dicarboxylic acid (“FDCA”) to an esterification reactor and in the presence of an alcohol compound such as methanol, conducting an esterification reaction to form an esterification vapor containing DAFD, unreacted alcohol compound, 5-(alkoxycarbonyl)furan-2-carboxylic acid (ACFC), and water, and continuously passing the esterification vapor through an ACFC condensing zone, that can be integral with the esterification reactor, in which at least a portion of the ACFC in the esterification vapor is converted to a liquid phase condensate, and continuously discharging the esterification vapor from the ACFC condensing zone as a DAFD vapor. There is also a DAFD vapor composition containing DAFD, water, unreacted alcohol, and by-products.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 29, 2015
    Inventors: Lee Reynolds Partin, Ashfaq Shaikh, Mesfin Ejerssa Janka, Kenny Randolph Parker
  • Method for Producing 5-Hydroxymethyl-2-Furfural from Maize Syrup Containing Fructose
    Publication number: 20150031904
    Abstract: Provided herein is a method for producing 5-hydroxymethyl-2-furfural (HMF) from maize syrup containing fructose including a conversion step in which a reaction product containing the 5-hydroxymethyl-2-furfural is produced by mixing and heating the maize syrup, a dioxane solvent and a solid acid catalyst, thus providing an advantage that the solvent can be easily isolated and the isolated solvent can be reused because dioxane is used as the solvent, and an advantage that the catalyst can be easily isolated and the isolated catalyst can be easily reused because a nonuniform solid acid catalyst is used.
    Type: Application
    Filed: July 26, 2012
    Publication date: January 29, 2015
    Inventors: Jin Ku Cho, Jaewon Jeong, Sangyong Kim, Bora KIM, Baek-Jin Kim, Seunghan Shin, Dohoon Lee
  • ALKYLENE OXIDE SEPARATION SYSTEMS, METHODS, AND APPARATUSES
    Publication number: 20150031905
    Abstract: A propylene oxide separation system that comprises a distillation column, a decanter, and water wash system. The distillation column is configured to receive a crude propylene oxide stream, discharge an impurity stream that comprises methanol and water, and discharge a bottoms stream that comprises a majority of the propylene oxide entering in the crude propylene oxide stream. The decanter is configured to receive at least a portion of the impurity stream and a hydrocarbon solvent to provide for formation in the decanter of an organic phase and an aqueous phase. The organic phase comprises propylene oxide and hydrocarbon solvent, and is sent to the distillation column. The aqueous phase comprises a majority weight percent of the methanol and the water entering in the impurity stream. The water wash system is configured to receive and purge the aqueous phase from the propylene oxide separation system.
    Type: Application
    Filed: July 21, 2014
    Publication date: January 29, 2015
    Inventors: Xiangmin Li, Te Chang, David W. Leyshon, Walter S. Dubner, Elizabeth I. Ross-Medgaarden
  • FLAME RETARDANT FILLER
    Publication number: 20150031906
    Abstract: A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards (PCBs), connectors, and other articles of manufacture that employ thermosetting plastics or thermoplastics. In this example, brominated silica particles serve both as a filler for rheology control (viscosity, flow, etc.) and a flame retardant. In an exemplary application, a PCB laminate stack-up includes conductive planes separated from each other by a dielectric material that includes a flame retardant filler comprised of brominated silica particles. In an exemplary method of synthesizing the brominated silica particles, a monomer having a brominated aromatic functional group is reacted with functionalized silica particles (e.g., isocyanate, vinyl, amine, or epoxy functionalized silica particles).
    Type: Application
    Filed: October 13, 2014
    Publication date: January 29, 2015
    Inventors: Dylan J. Boday, Joseph Kuczynski, Robert E. Meyer, III
  • METHOD FOR PRODUCING ACRYLONITRILE
    Publication number: 20150031907
    Abstract: The invention relates to a method for producing acrylonitrile which includes a vapor phase catalytic ammoxidation process of performing vapor phase catalytic ammoxidation by bringing a source gas containing propylene, molecular oxygen, and ammonia into contact with a fluidized bed catalyst to obtain acrylonitrile. The method is characterized in that the fluidized bed catalyst consists of particles containing Fe, Sb, and Te, and the vapor phase catalytic ammoxidation process is performed while maintaining a B/A in the range of 2.0 to 5.0, where A denotes an atomic ratio of Te/Sb in a bulk composition of the fluidized bed catalyst and B denotes an atomic ratio of Te/Sb in a surface composition of the particles of the fluidized bed catalyst. According to the method for producing acrylonitrile of the invention, it is possible to stably maintain a high acrylonitrile yield over a long period of time.
    Type: Application
    Filed: February 26, 2013
    Publication date: January 29, 2015
    Applicant: Mitsubishi Rayon Co., Ltd.
    Inventors: Takashi Karasuda, Hirokazu Watanabe, Motoo Yanagita, Kazufumi Nishida
  • METALLATED METAL-ORGANIC FRAMEWORKS
    Publication number: 20150031908
    Abstract: Porous metal-organic frameworks (MOFs) and metallated porous MOFs are provided. Also provided are methods of metallating porous MOFs using atomic layer deposition and methods of using the metallated MOFs as catalysts and in remediation applications.
    Type: Application
    Filed: July 17, 2014
    Publication date: January 29, 2015
    Inventors: Wojciech Bury, Omar K. Farha, Joseph T. Hupp, Joseph E. Mondloch