Abstract: Compounds, compositions, methods of making, and methods of using analogues of (?)-picropodophyllin, as well as a transgenic animal model and its use for identifying anticancer agents.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating nervous system disorders, which contains sulfuretin or a pharmaceutically acceptable salt thereof, and a method of using the composition to prevent or treat nervous system disorders. Moreover, the present invention relates to a functional food composition for alleviating nervous system disorders, which contains sulfuretin or a pharmaceutically acceptable salt thereof. The pharmaceutical composition and the functional food composition can be effectively used to prevent or treat degenerative brain disorders caused by a variety of cerebral nervous system abnormalities in persons, as well as depressive disorder and anxiety.

Abstract: The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non-cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.

Abstract: An antimicrobial composition for extending the shelf-life of water, feed or feed ingredients, comprising: water, a mixture of CrC18 organic acids, a mixture of CrC24 aldehydes, 5-25 wt. % pelargonic acid, and 5-30 wt. % trans-2-hexenal.

Abstract: The present invention relates to compositions of peracids, such as peroxycarboxylic acids, having reduced odor compared to conventional peracid compositions. The invention further relates to methods employing such compositions, and methods of making these compositions. Typically, the reduced-odor antimicrobial compositions include an alcohol for the esterification reaction to remove short- to mid-chain length malodorous carboxylic acids.

Abstract: Methods and systems for on-site generation of peracid chemistry, namely peroxycarboxylic acids and peroxycarboxylic acid forming compositions, are disclosed. In particular, an adjustable biocide formulator or generator system is designed for on-site generation of peroxycarboxylic acids and peroxycarboxylic acid forming compositions from sugar esters. Methods of using the in situ generated peroxycarboxylic acids and peroxycarboxylic acid forming compositions are also disclosed.

Abstract: The present invention relates to a compound with the core structure of formula (I), or pharmaceutically acceptable salts or esters, solvates, or prodrugs thereof, for use in the treatment of cognitive impairment in a mammal. The compound is preferably isosteviol or steviol, or pharmaceutically acceptable salts or esters, solvates, or prodrugs thereof.

Abstract: The present invention relates to compositions including surfactant peroxycarboxylic acid, methods for making these compositions, and methods for reducing the population of a microorganism.

Abstract: Fulvic acid as the active ingredient is used in the treatment or inhibition of multi-drug resistant bacteria, in particular NDM-1 bacteria producing carbapenemase or extended-spectrum lactamase (ESBL) resistant bacteria. The multi-drug resistant bacteria may be gram negative bacteria including, but not limited to, Klebsiella pneumoniae or Escherichia coli. The fulvic acid can be provided in combination with one or more antibiotics from the class of carbapenems or polymyxin antibiotics.

Abstract: Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.

Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.

Abstract: This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity) (e.g., PXD-101, N hydroxyl-3-(3-phenylsulfamoyl-phenyl)-acrylamide)) and one or more additional ingredients selected from cyclodextrin, arginine, and meglumine. The present invention also pertains to the use of such compositions, for example, in the inhibition of HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.

Abstract: There is provided a novel use of ramalin for preventing or treating liver diseases, and more specifically, a pharmaceutical composition for preventing or treating hepatic fibrosis or cirrhosis containing ramalin or a pharmaceutically acceptable salt thereof, and a functional food containing the same. It was confirmed that at the time of applying ramalin, which is a compound derived from Ramalina terebrata according to the present invention, to animal models, ramalin may remarkably suppress hepatic fibrosis and lower liver cirrhosis levels as compared to silymarin known as a liver cell protecting ingredient without cytotoxicity to normal liver cells, such that ramalin may be effectively used for preventing or treating hepatic fibrosis and liver cirrhosis.

Abstract: A coating comprised of a polymeric material and a bioactive agent where the properties of the casting solvent dictate the dispersion of the embedding bioactive agent. In preferred embodiments, controlled release of the bioactive agent is achieved by homogeneous dispersion of the bioactive agent within the coating. A further aspect of the invention is directed to formulations where the heterogeneous dispersion of the bioactive agent provides an initial rapid release of the bioactive agent. Methodology for production of coating formulations of the desired properties and the application of the coating to an article are also described.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating a muscle wasting-related disease comprising diaminodiphenylsulfone (Dapsone; DDS) or a pharmaceutically acceptable salt thereof as an active ingredient. The composition according to the present invention may be effectively used to prevent or treat a muscle wasting-related disease by increasing muscle mass, preventing muscle loss and effectively restoring muscle function.

Abstract: This invention provides a solid pharmaceutical composition comprising rasagiline or a pharmaceutically acceptable salt of rasagiline, and particles having a non-filamentous microstructure of at least two sugar alcohols. This invention also provides a solid pharmaceutical composition comprising rasagiline or a pharmaceutically acceptable salt of rasagiline, a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols, a supplemental sugar alcohol, a supplemental flow agent, and a supplemental disintegrant. This invention further provides a method of treating a subject afflicted with Parkinson's disease comprising administering to the subject a therapeutically effective amount of the solid pharmaceutical composition, thereby treating the subject. Finally, this invention provides a process of making such solid pharmaceutical compositions.

Abstract: A composition and method for treating infertility and sexual dysfunction of a male or female human by balancing hormone levels of cortisol, dehydroepiandrosterone sulfate, testosterone, progesterone, and estradiol in the human. The composition comprises effective amounts of spermine and spermidine, administered at least once daily for a period of at least thirty days.

Abstract: Disclosed are methods of preventing, treating, or diagnosing in a subject a disorder in protein folding or aggregation, or amyloid formation, deposition, accumulation, or persistence consisting of administering to said subject a pharmaceutically effective amount of inositol stereoisomers, enantiomers or derivatives thereof.

Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: A process and system for recovering at least one polyamide from one or more composite materials is provided. The process comprises dissolving the at least one polyamide present in the one or more composite materials in a solvent. The process further comprises separating at least one undissolved polymer from the solution by filtration. Furthermore, the process comprises evaporating part of the solvent from the solution containing the at least one polyamide. Also, the process comprises neutralizing, using an alkali, the solvent remaining with the at least one polyamide. In addition, the process comprises washing, filtering and drying the mixture comprising the at least one polyamide to obtain polyamide.

Abstract: Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising: a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.

Abstract: The present invention discloses a method for preparing a microporous polyolefin film comprising: a step of injecting a composition comprising polyolefin 30 to 60 wt % and a diluent, which can make liquid-liquid phase separation with the polyolefin thermodynamically 40 to 70 wt %, into an extruding machine, and melting and kneading thereof to prepare a single phase melt; and a step of extruding the melt while conducting liquid-liquid phase separation by passing through a section having the temperature below the liquid-liquid phase separation temperature and forming thereof in the form of a sheet, and a microporous polyolefin film prepared according to the method.

Abstract: The present invention is directed to the use of a disalt of malic acid in the production of a polyurethane foam to lower the glass transition temperature of the polyurethane foam obtained, wherein the disalt of malic acid is added to the reaction mixture comprising at least a polyol component, an isocyanate component, a catalyst to catalyse urethane or isocyanurate bond formation, an optional blowing agent and optionally further additives, and also to a polyurethane foam having a glass transition temperature of ?20° C. to 15° C., which polyurethane foam is characterized in that it comprises disalts of malic acid or reaction products thereof with an isocyanate component, wherein the fraction accounted for by the disalts and the reaction products thereof with an isocyanate component is below 0.08 wt % based on the polyurethane foam.

Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer and an acrylate monomer. In one embodiment, the thiol monomer reacts with the vinyl sulfone monomer preferentially over the acrylate monomer, and this differential selectivity allows for the control of the architecture of crosslinking polymer network. The invention further includes a composition comprising an electrophilic monomer, a nucleophilic monomer, a nucleophilic catalyst and an acid, wherein the concentrations of the nucleophilic catalyst and acid are selected as to provide a specific induction time for the polymerization reaction of the composition.

Abstract: A liquid mineral coating is disclosed which formulation includes calcium hydroxide (Ca(HO)2) and magnesium hydroxide Mg(OH2) associated with an organic polymer, allowing control of fungal growth and coating blistering or peeling due to rising moisture in the substrate, keeping the environment stable, without the need of adding stabilizers, such as D-Sorbitol, commonly used in conventional mineral coatings.

Abstract: The present invention relates to a method to prevent deactivation of the metal catalyst in a catalytic polymerisation process of polymeric binders whereby pyrithione biocides are present which method comprises the addition of a Zn, Cu or Na salt selected from Zn, Cu or Na salts of fatty acids such as e.g. Zn, Cu or Na octoate, Zn, Cu or Na acrylate, Zn, Cu or Na neodecanoate, or Zn, Cu or Na salts of beta diketones such as e.g. Zn, Cu or Na acetylacetonate.

Abstract: A pressure-sensitive adhesive composition containing an acrylic copolymer (A) having a structural unit (a1) derived from an alkyl (meth)acrylate (a1)? and a structural unit (a2) derived from a functional group-containing monomer (a2)?, a crosslinking agent (B), and a photochromic dye (C) selected from a group consisting of dithienylethene-based compounds, oxazine-based compounds and naphthopyran-based compounds has a relatively rapid rate of color change from colored to colorless after termination of irradiation with UV rays, has excellent photochromic performance and can be a pressure-sensitive adhesive layer of a colorless pressure-sensitive adhesive sheet.

Abstract: This invention provides processes for forming powders comprising at least one active compound and at least one carrier. The processes comprise (i) heating at least one active compound to at least its melting point or softening point; and (ii) in an extruder, combining at least the at least one active compound with at least one carrier, to form combined ingredients, and cooling the combined ingredients as they pass through the extruder, such that the combined ingredients exit the extruder at about ambient temperature in the form of a powder having particles sized so that about 95 wt % or more of the powder passes through a screen of about 8 standard U.S. mesh.

Abstract: One variation includes a friction material wherein the friction material may be fabricated from fibers, particles, a chemical binder, and a resin bonding agent wherein the particles are aggregated.

Abstract: A low copper-containing friction material composition used for brake pad is provided, which consists of the following components by weight parts: 4˜6 parts of aramid fiber, 2˜2.5 parts of tyre powder, 5˜6 parts of heavy magnesia, 5˜6 parts of red vermiculite, 8˜10 parts of ceramic fiber, 3.5˜5 parts of magnetite, 7˜8 parts of boron-containing phenolic resin, 15˜17 parts of calcium sulfate crystal whisker, 16-18 parts of potassium titanate, 15˜17 parts of barite, 5.5˜7 parts of flake graphite, 6˜8 parts of friction powder of cashew nut oil, 6˜8 parts of calcined petroleum coke, 1.5˜2 parts of boron nitride, 5˜7 parts of flake aluminum powder, 0.4˜0.5 parts of pure copper fiber, 0.4˜0.6 parts of black silicon carbide. Said friction material composition is highly environmental friendly and has low content of heavy metal, wherein the content of copper is lower than 0.5%, and an excellent friction layer and transfer membrane can be formed when using said friction material composition.

Abstract: A rubber tyre compound having a polymer base; a curing system, which cures the polymer base by means of heating; and basalt fibres with a length/diameter ratio ranging from 20 to 2000.

Abstract: The present invention relates to vulcanizable rubber mixtures comprising at least the following components: I.) 100 parts by weight of an oil-free rubber matrix consisting of a) 15 to 79 parts by weight, preferably 20 to 70 parts by weight, of at least one solution SBR (S-SBR) (oil-free) having a glass transition temperature (Tg(S-SBR)) between ?70° C. and ?10° C., b) 20 to 75 parts by weight, preferably 25 to 70 parts by weight, of at least one 1,4-cis-polybutadiene (BR) (oil-free) having a glass transition temperature (Tg(BR)) between ?95° C. and ?115° C., c) 1 to 37.5 parts by weight, preferably 5 to 35 parts by weight, of natural rubber (NR) (oil-free) and/or at least one synthetic polyisoprene (IR) having a glass transition temperature (Tg(NR)) between ?50° C. and ?75° C. based on the oil-free natural rubber (NR) or the oil-free, synthetic polyisoprene (IR), II.) at least one hydroxyl-containing microgel based on polybutadiene, III.) at least one hydroxyl-containing, oxidic filler, IV.

Abstract: The invention provides a rubber composition for use in tire treads that enhances low rolling resistance, wet performance and wear resistance to conventional levels or above. It comprises, per 100 parts by weight of a diene rubber containing from 35% to 89% by weight of a modified conjugated diene polymer rubber and from 11% to 40% by weight of a butadiene rubber, from 3 to 60 parts by weight of an aromatic modified terpene resin and from 100 to 150 parts by weight of a filler; the filler containing not less than 70% by weight of a silica; a ratio Wte/Wbr of the compounded amount of the aromatic modified terpene resin Wte to the compounded amount of the butadiene rubber Wbr being from 0.5 to 1.

Abstract: Disclosed is a method of preparing a rubber composition comprising the steps of (a) blending in at least one preparatory mixing step at least one natural or synthetic rubbery polymer, a silica filler, a silica coupling agent, and at least one vulcanization accelerator; and (b) subsequently blending therewith in a final mixing step a sulfur curative, wherein the average glass transition temperature of the polymer(s) is ?55° C. or less.

Abstract: A multifunctional syntactic foam including a matrix material and hollow particles, where a first and second material property of the syntactic foam are tailored on the basis of the wall thickness and volume fraction of the hollow particles.

Abstract: The invention relates to a method for in-situ synthesis of silicon nanoparticles in a thermosetting polymeric matrix, the thermosetting and thermoset matrices obtained in this way and a material including same. The method includes the following steps: a) forming an aqueous-phase/organic-phase inverse emulsion, wherein the aqueous phase includes at least a basic catalyst and the organic phase includes at least a non-cross-linked (co)polymer precursor chosen from an aliphatic, cycloaliphatic or aromatic epoxy resin precursor, a polyester-imide precursor, an unsaturated/epoxy polyester (co)polymer precursor, a polyether/epoxy (co)polymer precursor and a polyurethane precursor; b) introducing, into the inverse emulsion formed in step a), at least one silicon precursor forming a complete network whereof the rate of hydrolysis is greater than the cross-linking speed of the (co)polymer and c) stirring the mixture obtained in step b) and heating to a temperature between 20° C. and 70° C.

Abstract: After step (I) of kneading a diene rubber and a carbon black to be mixed with each other, and then discharging the resultant mixture containing the diene rubber and the carbon black from an internal mixer, step (II) of kneading the mixture again in the internal mixer to crush a re-aggregate of the carbon black in the mixture, and step (III) of charging the dihydrazide compound into the internal mixer, and kneading the mixture and the dihydrazide compound to be mixed with each other are carried out. The period of step (II) for the kneading is 15 seconds or longer, and the rotating speed of the stirring rotor of the internal mixer is 35 rpm or more. The period of step (III) for the kneading is 40 seconds or longer, and the rotating speed of the stirring rotor of the internal mixer is from 15 to 25 rpm.

Abstract: A method for blending functionalized silica with styrene butadiene rubber or ethylene propylene diene monomer rubber can include silica and an organosilane chemically and covalently bound to a surface of the silica. The organosilane can be derived from an organic silane with a functional group. A silica rubber masterbatch for complexing with an emulsion styrene butadiene rubber latex, a synthetic polymer, a natural polymer, or combinations thereof can include the functionalized silica with the organosilane or a blend of organosilanes chemically and covalently bound to a surface of the silica. Each organosilane can have an average tetrameric structure having a T3/T2 ratio of 0.3 to 0.9 or greater as measured by 29Si silicon cross polarization magic angle spinning nuclear magnetic resonance.

Abstract: To provide a room temperature-curable coating composition that has superior weatherability, in which cracking over time is suppressed due to by-products not being produced when curing, and the environmental burden is low due to an organic solvent not being included. This invention relates to a room temperature-curable coating composition comprising (A) an epoxy-functional organopolysiloxane and (B) an amino-functional organopolysiloxane.

Abstract: A composite material is disclosed for use in a high-voltage device having a high-voltage electrical conductor, the material containing a polymeric matrix and at least one fiber embedded in the polymeric matrix, the fibers having an average diameter of less than about 500 nm.

Abstract: Provided are compositions, methods and systems including cementitious compositions and reinforcing materials wherein the cementitious composition comprises a metastable component.

Abstract: The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.

Abstract: A dispersion spun fluoropolymer fiber prepared from non-melt-processible polytetrafluoroethylene particles and aluminum oxide particles. The concentration of Al2O3 in the aqueous dispersion may range from between about 0.1% to about 5%, with specific concentration of 0.1%, 1.0. The aqueous dispersion is mixed with an aqueous matrix polymer solution containing a matrix polymer and then extruded into a coagulation bath containing a concentration of ions which coagulate the matrix polymer to form an intermediate fiber structure which carries ionic species. The intermediate fiber structure is sintered to decompose the matrix polymer and coalesce the polytetrafluoroethylene particles and the Al2O3 particles into a blended fiber. The resulting, blended fluoropolymer fiber exhibits improved properties relative to 100% dispersion spun polytetrafluoroethylene fibers.

Abstract: This invention relates to a biodegradable polymer composition which is particularly suitable for use in the manufacture of articles having a high heat deflection temperature (HDT) by injection moulding and thermoforming.

Abstract: The present invention relates to a plastics-material strapping band (4) for wrapping around one or more articles. The plastics-material strapping band has the following constituent parts: a) up to approximately 90% by weight polyester, b) approximately 1% by weight to 5% by weight polyolefin and c) approximately 5% by weight to 10% by weight fibre material. The invention also relates to a method for producing a plastics-material strapping band.

Abstract: Cellulose nanofibers include: a linear portion; and a curved portion, in which an average of a length of the linear portion and an average of a maximum diameter of the linear portion have a relationship that satisfies the following Equation (a): (The average of the length of the linear portion)/(The average of the maximum diameter of the linear portion)?10??Equation (a)

Abstract: Certain phosphonic acid salts heated at temperatures over 200° C. generate thermally stable, highly efficient flame retardant materials well suited for use as flame retardant additives in polymers. The flame retardants of the invention can be used as the sole flame retardant in a composition or in combination with other flame retardants, synergists or adjuvants.

Abstract: Moisture-curable compositions are provided which comprises a moisture-curable silylated resin, a flexibilizer and at least one curing catalyst. The cured compositions possess enhanced elongation and tear properties, and are highly suitable for applications such as adhesives, sealants, coatings, gaskets, industrial rubber goods, and the like.

Abstract: A curable clear coat component for use in a two-component clear coat coating composition system is provided. The curable clear coat component comprises A) a polyaspartic acid ester or a hydroxyl functional binder or a combination of both, and B) an antioxidant component comprising B1) a sterically hindered phenol antioxidant, and B2) an organophosphite antioxidant.

Abstract: The invention relates to a photosensitive polysiloxane composition and a thin film formed by the aforementioned photosensitive polysiloxane composition. The thin film is a planarization film of a TFT substrate, an interlayer insulating film or an overcoat of a core material or a protective material in a waveguide. The invention is to provide a photosensitive polysiloxane composition having excellent surface flatness and high tapered angle of a pattern. The photosensitive polysiloxane composition comprises a polysiloxane (A), an o-naphthoquinone diazide sulfonic acid ester (B), an alkali-soluble resin containing a silyl group (C) and a solvent (D).