Abstract: The endoscope system includes an image signal acquisition processing unit and an image generation unit that acquire a first still image and a video or a second still image before and after acquisition of the first still image based on an image signal obtained by imaging an observation target using an image sensor, an association unit that associates the first still image with the video or associates the first still image with the second still image, and a storage unit that stores the first still image and the video associated with each other or stores the first still image and the second still image associated with each other.

Abstract: An endoscope includes: a tip portion main body provided at a tip portion of an insertion section; a camera unit attachment hole provided so as to penetrate the tip portion main body; a camera unit of which tip portion is fitted into a tip portion of the camera unit attachment hole; a locking member disposed at an outer peripheral surface of the camera unit so as to be movable in a direction that is orthogonal to the axial direction; a projection provided on either one of the locking member and the camera unit; a sliding portion provided on the other one of the locking member and the camera unit; and a locking biasing member configured to bias the locking member in the direction t orthogonal to the axial direction within the camera unit attachment hole and to push the locking member against the camera unit attachment hole.

Abstract: There is provided an observation attachment and a display apparatus achieving reduction in a burden of visual line movement of a user. The observation attachment is mounted on a surgical microscope having an eyepiece. The observation attachment includes a mounting member attached to the surgical microscope and a display holding member which holds a display provided with a display screen displayed with information for assisting a work of a user in using the surgical microscope, the information being different from an object's image directly observed through the eyepiece, and places the display screen of the display around the eyepiece of the surgical microscope in an attached state that the mounting member is attached to the surgical microscope.

Abstract: Disclosed is an ophthalmic photography device for capturing an eye including: a first photography optical system that captures a first image of the eye by capturing the eye by performing a first type of photography; a second photography optical system that captures a second image of the eye by capturing the eye by performing a second type of photography; a third photography optical system that captures a front image of the eye by capturing the eye using a third type of photography; and a controller for acquiring a first front image when the first image is acquired, and acquiring a second front image different from the first front image when the second image is acquired; and for detecting the amount of positional deviation between the first and second front images, and correlating the first image to the second image based on the amount of positional deviation.

Abstract: An optical measuring device includes a light source module, a light coupling module, a reference mirror module and a processing unit. The light source module can provide a light. The light of the light source module is transmitted to the reference mirror module and an under-test object through the light coupling module. The light is reflected by the reference mirror module and the under-test object to form a first light and a second light, respectively. The first and second lights are then transmitted to the processing unit through the light coupling module. The processing unit generates an adjusting signal according to the first and second lights. The processing unit transmits the adjusting signal to the reference mirror module. The reference mirror module adjusts the reference mirror module according to the adjusting signal.

Abstract: A fundus photography device includes: an OCT optical system configured to detect interference between a measurement light from a fundus of a subject's eye and a reference light from a reference optical path; a fundus photography optical system configured to detect a reflected light from the fundus; a controller configured to generate a tomographic image of the fundus and a first front image of the fundus based on an output signal from the OCT optical system, and generate a second front image of the fundus based on an output signal from the fundus photography optical system. The controller is configured to cause simultaneous display of the first front image and the second front image in different display regions on a monitor.

Abstract: A fundus photography device includes: a fundus illumination optical system that illuminates a fundus of an eye by illumination light; a fundus photography optical system; an OCT optical system; an anterior chamber observation optical system for observing an anterior chamber observation image of the eye illuminated by the anterior chamber illumination light source; a first wavelength separation member that sets a first optical axis commonly shared by the fundus illumination optical system and the fundus photography optical system to be coaxial with a second optical axis commonly shared by the OCT optical system and an anterior chamber observation optical system; and a second wavelength separation member that forms the second optical axis by setting an optical axis of the OCT optical system to be coaxial with an optical axis of the anterior chamber observation optical system.

Abstract: Provided is an ophthalmologic apparatus capable of determining whether measurement light is properly projected onto an eye to be examined. The apparatus includes an ocular characteristics measurement unit that measures an optical characteristic of the eye by projecting measurement light onto the eye and receiving light reflected by the eye, an observation optical system that acquires an image of an anterior ocular segment, a measurement area projection optical system that projects measurement area index light onto a cornea of the eye from a position defined in accordance with an optical axis of the ocular measurement unit, and a control unit that controls the ocular characteristics measurement unit, the observation optical system, and the measurement area projection optical system. The control unit determines whether the measurement light is properly projected onto the eye based on the acquired image of the anterior ocular segment including the measurement area index light.

Abstract: The present invention provides an ophthalmologic apparatus that includes an acquiring unit that acquires a tomographic image of a fundus of an eye to be inspected, and a display control unit that controls a display unit to display, in a state of corresponding to the acquired image, a comparison area corresponding to another tomographic image to be compared with the acquired tomographic image.

Abstract: Disclosed are various embodiments for imaging retinal intrinsic optical signals (IOS) in vivo. According to various embodiments, imaging retinal intrinsic optical signals (IOS) may comprise illuminating a host retina with near infrared light (NIR) during a test period, wherein the host retina is continuously illuminated by the NIR light during the test period. Sequentially a host retina may be stimulated with a timed bursts of visible light during the test period. A series of images of the retina may be recorded with a line-scan CCD camera and the images may be processed to produce images of intrinsic optical signals (IOS) from retinal photoreceptor cells identified in the images.

Abstract: An imaging system for an optical element, the imaging system comprising means for illuminating a targeted optical element with at least one incident light beam and means for directing at least two light beams returning from at least one surface of the illuminated optical element onto a detector; the detector adapted to measure relative light characteristics of the at least two returning light beams and to calculate at least one parameter of the optical element using the measured characteristics of the at least two returning light beams.

Abstract: A device for measuring tissue hardness of a subject comprising: a housing, the housing having a proximal end and a distal end; a contact probe configured to contact tissue arranged on the distal end of the housing; a sensor assembly configure to measure tissue hardness disposed within the housing; a microprocessor configured to receive input from the sensor assembly; a force transduction assembly disposed within the housing; a microprocessor receiving input from the displacement sensor and the force sensor; and a display, receiving input from the microprocessor, configured to display information to a user on the proximal end of the housing.

Abstract: A medical instrument that comprises: a first-stage optic responsive to a tissue surface of a patient; a spectral separator optically responsive to the first stage optic and having a control input; an imaging sensor optically responsive to the spectral separator and having an image data output; and a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor and a filter control interface having a control output provided to the control input of the spectral separator.

Abstract: An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first waveguide receives the first radiation, and the second waveguide receives the second radiation. The first arrangement, the second arrangement and the configuration can be housed in a probe.

Abstract: A single optical fiber force-sensing assembly includes a catheter configured to detect both axial and bending tip displacement. The catheter includes a flexible structure located adjacent to a distal tip portion of the catheter. The single optical fiber within the catheter defines a first reflective surface. A second reflective surface is located closely adjacent to the first reflective surface.

Abstract: A photoacoustic medical-imaging device includes a wavelength conversion assembly (108) configured for outputting laser pulses at a targeted wavelength. It also includes a photoacoustic probe configured for acoustic coupling to a patient, for directing the pulses, and for acquiring, in response, radiofrequency data for photoacoustic imaging. It may include an optical fiber bundle (120) that comprises an optical fiber having an input end, and be configured for illuminating, with a homogenous beam, so as to conform to an acceptance angle (160) of the fiber at that end. It may also include a light collimator, and a diffuser for receiving the outputted laser pulses from the collimator. The diffuser may be configured for spreading a focus of the pulsed light (148) over an input aperture of the bundle to equalize the light received by different constituent optical fibers of the bundle. The assembly may include a dye cell (132), and may reside in the probe.

Abstract: System and method for obtaining information about a target structure. The system includes an optoelectrical element with an optical fiber having a core, a coating surrounding the core, an optical axis, a proximal end, and a distal end. The optoelectrical element also includes an electrical connector embedded within the coating along the optical axis between the proximal end and the distal end. A. transducer is disposed at the distal end and electrically connected to the electrical connector. The transducer is operable to detect a first energy, generated in response to light that has been transmitted from the proximal end to the distal end and outcoupled from the distal end toward the target structure, and to convert the received first energy to an electrical signal to be transmitted along the electrical connector.

Abstract: Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths.

Abstract: The disclosed technology includes a temperature-sensitive pacifier for providing early warnings of dangerous temperature-related conditions, such as fever or a risk of heat stroke. The temperature-sensitive pacifier may integrate a thermochromic material into the nipple, neck, and base portions of the pacifier to provide a visual indication of an oral temperature condition, and separately provide a visual indication of an environmental temperature condition.

Abstract: Embodiments include a system for determining patient cardiovascular information which includes at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of a patient; create a model representing at least a portion of the anatomical structure of the patient based on the patient-specific data; determine a first blood flow rate at at least one point of interest in the model by using relations of individual-specific anatomic data to functional estimates of blood flow characteristics generated from a plurality of individuals; modify the model; determine a second blood flow rate at a point in the modified model corresponding to the at least one point of interest by using the relations of individual-specific anatomic data to functional estimates of blood flow characteristics; and determine a fractional flow reserve value as a ratio of the second blood flow rate to the first blood flow rate.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, an intravascular pressure measurement device is provided. The intravascular device includes a flexible elongate member with a proximal portion and a distal portion and a lumen extending therethrough. The lumen is configured to allow the passage of a guidewire. The distal portion of the member includes first and second distal sections. The second distal section having an outer diameter that is smaller than the outer diameter of the first distal section. The intravascular device further includes a first pressure sensor disposed within the wall of the first distal section of the flexible elongate member to measure the pressure within the lumen.

Abstract: A method of processing a signal pertaining to at least one electrical property of an organ of a subject is disclosed. The method comprises determining a physiological condition of the subject, selecting a frequency band, filtering the signal according to the frequency band, and dynamically adapting the frequency band in response to a change in the physiological condition.

Abstract: An introducer includes a sheath for introducing a catheter into a blood vessel at an insertion site and a plurality of electrodes on the sheath. The introducer also includes an impedance assessment unit connected to the electrodes. The impedance assessment unit includes a power source and a wireless transceiver and is configured to inject one of a predetermined current or voltage across a first pair of electrodes and to measure the other of the current or voltage across a second pair of electrodes. The impedance assessment unit also is configured to perform at least one: wirelessly transmit current and voltage values to an external apparatus for detection of a bleed, and compute an impedance based on the current and voltage and wirelessly transmit the computed impedance to the external apparatus for detection of the bleed.

Abstract: A system configured to determine a characteristic of a patient includes a plurality of sensors, wherein each sensor of the plurality of sensors is configured to noninvasively determine a respective parameter of the patient, and wherein the parameter determined by each sensor is different from parameters determined by remaining sensors of the plurality of sensors. Such a system also includes a connector having a passage configured to direct pressurized fluid therethrough, wherein the plurality of sensors is connected to the connector.

Abstract: A magnetic resonance method and system are provided for generating real-time motion-corrected perfusion images based on pulsed arterial spin labeling (PASL) with a readout sequence such as a 3D gradient and spin echo (GRASE) image data acquisition block. The real-time motion correction is achieved by using a volumetric 3D EPI navigator that is provided during an intrinsic delay in the PASL sequence, which corrects for motion prospectively and does not extend the image data acquisition time as compared to a similar non-motion-corrected imaging procedure.

Abstract: Disclosed are systems and methods for timing measurements in a non-invasive blood pressure measurement system. The systems and methods are capable of providing measurement results according to patient-specific time intervals. The disclosed systems may include a pump unit, signal acquisition circuit, user interface, clock, memory, microprocessor, power unit and communications module. The disclosed invention also contains a method for calculating an expected measurement duration. Additionally systems and methods for providing blood pressure results according to patient-specific time intervals using an expected measurement duration are discussed. Related apparatus, systems, methods and or/articles are described.

Abstract: A method for monitoring pressure of blood in an artery may include contacting a non-invasive sensor of a pressure of blood monitoring device at an area above an artery of a finger, collecting with the sensor one or more pressure data readings, other than readings corresponding to an air pressure reading, from the area after the contacting and after a pressure is exerted at the area on the sensor; and analyzing with a computing device the one or more pressure data readings to generate at least one of a blood pressure reading and a heart pulse reading.

Abstract: What is disclosed is a system and method for determining whether a subject is in atrial fibrillation. A video is received of a region of exposed skin of a subject. The video is acquired of a region where a videoplethysmographic (VPG) signal can be registered by at least one imaging channel of a video imaging device. For each batch of image frames, pixels associated with the region of exposed skin are isolated and processed to obtain a time-series signal. A VPG signal is extracted from the time-series signal. The power spectral density (PSD) is computed across all frequencies within the VPG signal. A pulse harmonic strength (PHS) is calculated for this VPG signal. The pulse harmonic strength is compared to a discrimination threshold, defined herein. A determination is made whether the subject in the video is in atrial fibrillation or in normal sinus rhythm.

Abstract: A system, method and device are described for detecting a heart rate. A sensing unit can have a skin-facing surface that is removably securable to a user's skin surface and include at least one sensor positioned to acquire a bio-signal from the skin surface. A controller can be configured to capture a bio-signal stream using the at least one sensor and generate a preprocessed bio-signal stream by band-pass filtering the captured bio-signal stream with a predetermined passband. The controller can also be configured to determine, in a moving window, heartbeat signal portions when the preprocessed bio-signal stream has heartbeat impulse characteristics and determine the time between adjacent heartbeat signal portions to compute the heart rate.

Abstract: A heart rate monitor comprising an optical heart rate (OHR) sensor and a strap for mounting the sensor to a limb of a user is described. The OHR sensor comprises a sensing unit including at least one light emitter arranged to emit light into the skin of a user and a photodetector arranged to sense light reflected through the skin of the user. The sensing unit is arranged substantially centrally in the strap and the strap comprises compressible edge portions that run along opposite sides of the sensing unit such that, when the strap is mounted to a limb of a user, the edge portions are compressed against the skin to prevent or reduce the ingress of ambient light to the sensing unit.

Abstract: Preferably, an embodiment of a sensor probe assembly includes at least, a flexible, highly electrically conductive signal sensor component. The flexible, highly electrically conductive signal sensor component provides a main body portion, a plurality of spires protruding in a first direction from a first side surface of the main body portion, and a conductor confinement feature formed on a second side surface of the main body portion.

Abstract: A method and system for use with an implantable medical device for subcutaneous implant within a patient to determine a likelihood of the patient experiencing a cardiac event that includes sensing a cardiac signal along a plurality of different sensing vectors, determining state information of each vector of the plurality of sensing vectors, determining a cross correlation of the determined state information of each vector of the plurality of sensing vectors, comparing the cross correlation of the determined state information of each vector of the plurality of sensing vectors to a threshold, and detecting the cardiac event in response to the comparing.

Abstract: Provided is a method of analyzing brain activities for realizing a biomarker for neurological/mental disorder, based on brain function imaging. From measured data of resting-state functional connectivity MRI of a healthy group and a patient group, correlation matrix (80) of degree of brain activities among prescribed brain regions is derived for each subject. Feature extraction is executed by regularized canonical correlation analysis (82) on the correlation matrix (80) and attributes of the subject including a disease/healthy label of the subject. Based on the result of regularized canonical correlation analysis, by discriminant analysis (86) through sparse logistic regression, a discriminator (88) is generated.

Abstract: A method and system for high-throughput prediction of the onset of heart arrhythmias observes trends in abnormal or pathologic morphology of the electrocardiogram (ECG). A first set of ECG signals is monitored from a patient. A baseline measurement is generated from the monitored first set of ECG signals to contain nonpathologic ECG morphologies in each lead. A second set of ECG signals is monitored from the patient and a second baseline measurement is generated from the second set of ECG signals. A residuum signal is generated for each lead based on the baseline measurement and the second baseline measurement. The residuum signals are averaged across the leads. R-wave heterogeneity, T-wave heterogeneity, P-wave heterogeneity, or ST-segment heterogeneity or other indicators of arrhythmia risk or myocardial ischemia are quantified based on the generated residuum signals and the averaged residuum signal.

Abstract: An implantable device for analyzing a high frequency (HF) electrogram signal including an implantable electrode, a signal pickup configured to pick up an electrogram signal including a HF component, a signal filter connected to the signal pickup and configured to measure a HF component from the signal only during a specific portion of a cardiac cycle, and an analyzer for analyzing the HF component, wherein the signal pickup, the signal filter and the analyzer are included within an implantable container, and the analyzer is configured to analyze at least one time-varying parameter of the HF component, and the signal filter is configured to measure the signal by using a signal picked up from at least one electrode selected from a group consisting of (a) intracardiac, (b) subcutaneous, (c) a can of the implanted device, (d) a combination of two of the above. Related apparatus and methods are also described.

Abstract: A system and method for determining and controlling a cardiac condition of a subject are provided. In some aspects, the method includes acquiring ECG signals using one or more electrodes configured to sense a cardiac activity of a subject, and analyzing the ECG signals to delineate cardiac waveforms on a beat-to-beat basis. The method also includes identifying, in the delineated cardiac waveforms, characteristic points associated with different phases of cardiac activity, and for each delineated cardiac waveform, computing an ischemic index using the ECG signals corresponding to a ventricular depolarization period and a ventricular repolarization period, wherein the ventricular depolarization period and the ventricular repolarization period are defined by the identified characteristic points. The method further includes determining a cardiac condition of the subject using each computed ischemic index.

Abstract: A portable neurofeedback device is described. The neurofeedback device includes a wearable fixture. One or more brainwave sensors are attached to the wearable fixture. A processing unit is attached to the wearable fixture. The processing unit receives brainwave signals captured by the one or more brainwave sensors. The processing unit computes one or more user-feedback values that represent current brain activity. A display module is attached to the wearable fixture that displays a visual representation of the one or more user-feedback values.

Abstract: A device for physiological measurement. The device includes at least two terminal units connectable to each other, of which a first terminal unit includes an electric circuit, an ECG-electrode and a first connector assembly having at least one ECG-contact for connecting at least one other ECG-electrode. A second terminal unit includes other ECG-electrodes and a second connector assembly having a counter ECG-contact adapted to be fitted to the ECG-contact of the first connector assembly. The first and second terminal are together arranged to connect the ECG-electrode of each second terminal unit to the electric circuit in the first terminal unit and, as separated, are arranged to enable the use of the function contacts of the first connector assembly.

Abstract: Some aspects provide a method of determining a set of parameter estimates for an incoherent motion model from diffusion-weighted magnetic resonance data of a portion of a biological body. The method comprises determining a first set of parameter estimates for a plurality of voxels associated with one or more images based, at least in part, on the diffusion-weighted magnetic resonance data, determining a second set of parameter estimates by stochastically perturbing the first set of parameter estimates, determining a third set of parameter estimates based, at least in part, on the first set of parameter estimates and the second set of parameter estimates, and determining whether at least one criterion associated with the third set of parameter estimates is satisfied.

Abstract: Systems and method for producing functional brain organization maps are provided. The method includes providing functional connectivity magnetic resonance image (fcMRI) data, a population atlas, a variation map indicative of inter-subject variability in the atlas. The method also includes initializing a subject map using the atlas, determining a reference signal for each functional connectivity network in the subject map using signals derived from the fcMRI data, computing correlations between the signals and reference signal of each functional connectivity network, and iteratively updating the subject map by reassigning locations in the subject brain when correlating with a functional connectivity network, updating at each iteration the reference signal using the subject map, the population atlas, the variation map, and the set of fcMRI data. The method further includes generating a report indicative of a functional brain organization for the brain of the subject using the subject map.

Abstract: A system and methods for functional brain mapping is provided. The method includes providing a set of time-series functional magnetic resonance imaging (fMRI) data acquired from a brain of a subject while performing a functional task and decomposing the set of time-series fMRI data into a set of task signals and a set of non-task signals using a model related to the functional task performed by the subject. The method also includes generating a task activity map using the set of task signals and generating a non-task activity map using the set of non-task signals. The method further includes producing a combination map by selectively weighting the task activity map and non-task activity map, and combining the selectively weighted maps, using a statistical parameter, in dependence of a threshold.

Abstract: A device is described for measuring electrical characteristics of biological tissues with plurality of electrodes and a processor controlling the stimulation and measurement in order to detect the presence of abnormal tissue masses in organs. Examples of suitable organs are the breast, skin, oral cavity, lung, liver, colon, rectum, cervix, and prostate and determine probability of tumors containing malignant cancer cells being present in tissue. The approach can also be applied to biopsied tissue samples. The device has the capability of providing the location of the abnormality. The method for measuring electrical characteristics includes placing electrodes and applying a voltage waveform in conjunction with a current detector. A mathematical analysis method is then applied to the collected data, which computes spectrum of frequencies and correlates magnitudes and phases with given algebraic conditions to determine mass presence and type.

Abstract: A device for the detection of slippage of magnetic coupling between an implanted medical device having a magnet and an externally applied magnetic field includes at least one external magnet configured to apply the externally applied magnetic field, an induction coil disposed external to the subject and between the at least one external magnet and the implanted medical device, and a detection circuit operatively coupled to the induction coil and configured to detect slippage between the rotational orientation of the magnet of the implanted device and the externally applied magnetic field based at least in part on the varying frequency components of the voltage waveform across the induction coil.

Abstract: The invention relates to a position determination apparatus for determining the position of a working element (5) arranged within an object (3) having an inner structure with respect to a model of the object. The position and shape of a registration element (7) within the inner structure of the object are provided and used for determining a transformation relating the inner structure of the model and the position and shape of the registration element with respect to each other, wherein the position of the working element with respect to the model is determined depending on a provided spatial relation between the working element and the registration element and the determined transformation. In this way the position of the working element with respect to the model of the object can be determined without necessarily requiring x-ray projection images showing the working element and, thus, without necessarily applying x-rays to the object.

Abstract: Systems and methods may provide for identifying sensor data associated with an intraoral device and analyzing a chemical composition of an ingestible product based on the sensor data. Additionally, a notification may be selectively generated based on the chemical composition. In one example, analyzing the chemical composition includes determining the level of one or more of an allergen, a toxin or a predetermined substance in the ingestible product.

Abstract: A system for monitoring respiration, and a method for determining respiration rate, is disclosed. In one embodiment, the respiration rate is determined from a power spectral density template that is updated, or not, based on whether a power spectral density for a current window of in-band filtered impedance respiration signal is determined to be noisy or not.

Abstract: The present disclosure relates to a device for the measurement and analysis of the multiple breath washout process, where an ultrasound, flow and molar mass sensor determines the instantaneous flow and the instantaneous molar mass of the gas inspired and expired by the patient in the main flow.

Abstract: The present invention provides a method and engine for defining respiration events in body sensor signals that are highly accurate and compatible with many different classes of respiration monitoring devices. The present method and engine provide improved respiration event definition through the expedients of dynamic thresholding, segment merging and tail identification.

Abstract: A method of determining patient follow-up subsequent to an orthopaedic procedure includes determining the number of cycles of use of an orthopaedic joint of the patient. If a predetermined threshold is exceeded, communication with an orthopaedic care provider is initiated. A patient monitoring system is also disclosed.

Abstract: Orthopedic systems and methods are provided for use in preparing joints for implants. Specifically, hip preparation systems and methods are disclosed which can include a surgical orientation device. The hip preparation systems and methods can be used, for example, to orient the hip during the procedure, determine the orientation of an anatomical plane or planes, and orient a prosthetic component or components.