Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

Abstract: The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.

Abstract: The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfidebond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.

Abstract: The present invention provides Tenascin-3 FnIII domain-based multimeric scaffolds that specifically bind to TRAIL Receptor 2 (TRAIL R2), a cell membrane receptor involved in apoptosis. The invention further provides engineered variants with increased affinity for the target, increased stability, and reduced immunogenicity. Furthermore, the present invention is related to engineered multivalent scaffolds as prophylactic, diagnostic, or therapeutic agents, and their uses against diseases caused by cells expressing TRAIL R2, in particular to a therapeutic use against cancer.

Abstract: The present invention relates to process for reducing the endotoxin content of a sample of fermentation broth containing polysialic acid and endotoxin comprising the sequential steps: (i) adding to the sample a base having a pKa of at least 12 to form a basic solution having a pH of at least 12, incubating the solution for a pre-determined time at a pre-determined temperature; and (ii) recovery of PSA, suitably by (iii) passing the sample through an anion-exchange column whereby polysialic acid is absorbed on the ion exchange resin; (iv) washing the column with one washing buffer, whereby polysialic acid remains absorbed on the ion exchange resin; and (v) eluting the polysialic acid from the column using an elution buffer to provide a product solution of polysialic acid having reduced endotoxin content.

Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.

Abstract: In a process for producing high molecular weight polyethylene, ethylene is contacted with a slurry of a catalyst composition comprising a Group 4 metal complex of a phenolate ether ligand under polymerization conditions comprising a temperature of about 20° C. to less than 90° C. and a pressure of about 4 bar to about 40 bar.

Abstract: Process for the preparation of catalytic support and supported bimetallic catalysts for production of homopolymers and copolymers of ethylene with ?-olefins, of high and ultra high molecular weight and with broad molecular weight distribution in slurry, bulk and gas phase processes and products thereof. The present invention relates to a process for the preparation of catalytic support and the supported bimetallic catalysts, used in the production of ethylene homopolymers and ethylene copolymers with ?-olefins, of high and ultra high molecular weight with broad molecular weight distribution, in gas or liquid phase polymerization processes, the latter being in slurry, bulk or suspension, and the products obtained from these processes.

Abstract: Disclosed is a method for manufacturing carbon fiber which comprises the use of un-reacted raw material monomers in solution to prepare the precursor fiber for making the carbon fiber, and a relatively short passage period through hydrogen, which reduce production costs and increase returns. The present invention further comprises the carbon fiber precursors made thereby.

Abstract: The present invention provides an N-vinyl lactam polymer that is less likely to be colored (yellowing) even at high temperatures to maintain its color tone. The present invention provides an N-vinyl lactam polymer comprising a structural unit derived from an N-vinyl lactam monomer, the N-vinyl lactam polymer including a structural unit that has at least one of a hypophosphorous group and a group of hypophosphorous acid metal salt at a main chain terminal.

Abstract: Provided is an electronic microparticle, including a first copolymer copolymerized from a first monomer and a second monomer or a second copolymer copolymerized from the first monomer, the second monomer and a third monomer. The first monomer includes an alkenyl group and excludes a sulfonic group, a carboxylic group, a hydroxyl group and an amino group. The second monomer includes an alkenyl group and further includes a sulfonic group or a carboxylic group. The third monomer includes an alkenyl group and further includes a hydroxyl group or an amino group. Either the first monomer or the second monomer has a ratio of the repeating units of the first monomer to the repeating units of the second monomer between about 200:1 and 20:1. In addition, an addition agent and a filtering membrane which include the electronic microparticle illustrated above are provided.

Abstract: The present invention is directed to a method of making a copolymer, comprising the steps of at least partially epoxidizing a polyisoprene to produce an epoxidized polyisoprene; reacting the epoxidized polyisoprene with a dithiol to produce a thiol functionalized polyisoprene; and reacting the thiol functionalized polyisoprene with a thiolophile-functionalized polymer derived from a monomer having a hydrogen bond donor site and hydrogen bond acceptor site to form the copolymer.

Abstract: The present invention relates to an equipment and method for producing polymer pellets which comprise one or more polymer components and one or more further components, wherein in said process at least one of said one or more further components is incorporated into pellets by applying a liquid, which comprises said at least one component, onto said pellets.

Abstract: An optical film including a polymer including a repeating unit A including a repeating unit represented by the following Chemical Formulas 1 to 3, or a combination thereof; and a repeating unit B derived from a monomer having an unsaturated bond copolymerizable with the repeating unit A, wherein the optical film has a short wavelength dispersion of an in-plane phase-difference value (Re) (450 nm/550 nm) ranging from about 0.81 to about 1.20, and a long wavelength dispersion of an in-plane phase-difference value (Re) (650 nm/550 nm) ranging from about 0.90 to about 1.18: wherein, in Chemical Formulas 1 to 3, the variables R1 to R21 are defined herein.

Abstract: Process including polymerizing in a loop reactor an olefin monomer optionally together with an olefin commoner in the presence of a polymerization catalyst in a diluent to produce a slurry comprising solid particulate olefin polymer and the diluent. The Froude number is maintained at or below 20.

Abstract: Soil adsorption polymers and method for making same are provided.

Abstract: The present invention relates to curable mixtures for the sealing, encapsulation, bonding or coating of opto-electronic components, such as OLEDs, solar cells, optical sensors and liquid-crystal displays, or for the alignment of liquid crystals. The mixtures comprise in total at least 50 percent by weight of vinyl ethers.

Abstract: Disclosed are derivatives of (tetrahydropyranyl)methyl acrylamide and polymers derived therefrom, as well as methods of making such compounds and polymers. Adhesives, coatings, and plastics which include such polymers are also described.

Abstract: Methods of preparing a crosslinked polymer provide increased chemical durability resulting from the inclusion of antioxidants, or free-radical scavengers, to neutralize the radicals causing polymer membrane degradation. One method includes polymerizing, using an initiator with light irradiation or heat, a styrenated crosslinkable monomer with a styrene-based comonomer having the formula CH2?CH—C6H4—X and a free-radical scavenger. Examples of free-radical scavengers include 4-hydroxy styrene and 4-vinylaniline.

Abstract: The present disclosure relates to a method for controlling size distribution of formed polymer particles during preparation of aqueous polymer dispersion. The method comprises obtaining an aqueous polysaccharide solution, which comprises about 10 to 40 weight-% polysaccharide containing a free hydroxyl group, such as starch, and polymerising in the polysaccharide solution in the presence of a graft-linking, water-soluble redox system about 30 to 60 weight-% of at least one optionally substituted styrene, about 60 to 30 weight-% of at least one C1-C4-alkyl(meth)acrylate, and 0 to about 10 weight-% of other ethylenically unsaturated copolymerizable monomers. The size distribution of the formed polymer particles is controlled by adjusting viscosity of the polysaccharide solution before the polymerisation to a level less than about 20 mPas.

Abstract: The present application relates to an olefin-based ionomer resin composition, to an encapsulant, and to an optoelectronic device. The resin composition according to the present application may be used as an encapsulant for a variety of optoelectronic devices, and may exhibit superior adhesion to the substrates of the optoelectronic devices. In addition, according to the present application, an olefin-based ionomer resin composition, which can provide good workability and economic advantages in the manufacture of devices without negatively affecting components such as encapsulated optoelectronic elements or the wired electrodes of optoelectronic devices, may be provided.

Abstract: The present invention aims to provide a polyurethane resin for moisture-permeable waterproof materials which is excellent in all of the moisture permeability, waterproofness, and resistance to washing.

Abstract: A method of improving the mechanical strength of polyurethane foams made from bio-based polyols, the polyol-containing compositions utilized in the method of the invention, and the polyurethane foams produced by the method of the invention are provided. The method of the invention involves the incorporation of aromatic polyester polyol in the polyol-containing composition used to manufacture the foams. In one embodiment, the aromatic polyester polyol is utilized in a polyol-containing composition which is employed in the manufacture of flexible polyurethane foam. In another embodiment, the aromatic polyester polyol transesterified with a natural oil-containing composition to form a transesterification reaction product that is utilized in a polyol-containing composition which is employed in the manufacture of flexible polyurethane foam.

Abstract: The present disclosure relates to impact strength modifiers, the derivative products thereof, and the use thereof in producing two-component epoxy resin compositions. The disclosure in particular relates to amino group terminated impact strength modifiers prepared by reacting a polyurethane prepolymer having isocyanate groups, a primary diamine, and optionally at least one Michael acceptor. The two-component epoxy resin compositions thus formulated are characterized by a great increase in impact strength while retaining an acceptable tensile shear strength. The impact strength modifiers according to the disclosure and the epoxy resin compositions comprising same are in particular suitable for vehicle manufacturing.

Abstract: The present invention relates to dispersible polyurethanes and polyurethane dispersions curable with UV radiation, to a process for preparing them, and to their use.

Abstract: An epoxy resin composition for encapsulating a semiconductor device, the epoxy resin composition including an epoxy resin, a curing agent, and one or more inorganic fillers, the one or more inorganic fillers including prismatic cristobalite, the prismatic cristobalite being present in the epoxy resin composition in an amount of about 1 to about 50% by weight, based on the total weight of the epoxy resin composition.

Abstract: A copolymer containing a repeating unit having a dioxopyrrole condensed ring skeleton and a repeating unit having a dithieno condensed ring skeleton and also having a specific substituent is provided.

Abstract: A composition forms a resist underlayer film showing improved adhesiveness to a resist pattern. A resist underlayer film-forming composition for lithography, including: a polymer that has a structure of Formula (1a), Formula (1b), or Formula (2) below on an end of the polymer; and an organic solvent: (where R1 is a hydrogen atom or a methyl group; each of R2 and R3 is independently a hydrogen atom or an organic group such as a hydrocarbon group, etc., the hydrocarbon group optionally has at least one of a hydroxy group and a methylthio group as substituent(s); R4 is a hydrogen atom or a hydroxy group; Q1 is an arylene group; v is 0 or 1; y is an integer of 1 to 4; w is an integer of 1 to 4; x1 is 0 or 1; and x2 is an integer of 1 to 5).

Abstract: The invention relates to an unsaturated polyester resin comprising a) a lactic acid-modified unsaturated polyester and b) a copolymerizable comonomer, with replacement, with lactic acid, in the composition of an initial polyester, of: i) up to 90 mol % of phthalic anhydride of the acid component of the initial polyester, the acid component comprising from 80 to 20 mol % of maleic anhydride (MA) or fumaric acid, and from 20 to 80 mol % of phthalic anhydride (PA), the polyol component of the initial polyester comprising from 50 to 100 mol % of propylene glycol (PG) and from 0 to 50 mol % of a polyol among ethylene glycol (EG), diethylene glycol (DEG), dipropylene glycol (DPG) and/or 1,3-butylene glycol and/or 1,4-butanediol and/or neopentyl glycol (NPG), ii) up to 100% of a polyol from DPG and DEG, present in an initial overall molar amount ranging up to 50% of the polyol component of the initial polyester and also comprising PG, with the acid component of the initial polyester being maleic anhydride (MA) or f

Abstract: A polymer comprising as part of its polymer backbone a cineole-type moiety having a structure according to Formula (II): where one of R6 to R10 represents A-O— and one of R6 to R10 represents —O—B and the remainder of R6 to R10 represent H, where A and B, which may be the same or different, represent the remainder of the polymer backbone and are independently selected from the group consisting of polyurethane, polyester, polyamide, polycarbonate, polyimide, polyether, polyepoxy, polyacrylate, polysiloxane, polyvinyl and combinations thereof. The polymer comprising as part of its polymer backbone a moiety of Formula (II) or polymer blend, comprising this polymer, can be used for production of a sheet, fiber or film.

Abstract: The invention generally relates to the fields of drug delivery and cell capture. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for drug delivery vehicles and/or cell capture.

Abstract: A donor capable of controlled release of nitric monoxide and a prosthetic implant whose surface is coated with this donor are disclosed. The donor comprises a main chain of an organic polymer and a side chain that is covalently linked to the main chain and has a diazeniumdiolate functional group. The donor for controlled release of nitric monoxide exists in a fluid state such as liquid at room temperature and undergoes a sol-to-gel phase transition at a physiological pH as the temperature increases above the critical temperature. The critical temperature of the phase transition is in the range of 25 to 35° C., and the gel is a hydrogel without chemical cross-links.

Abstract: The invention relates to novel polymers containing 8,9-dihydrobenzo[def]carbazole units, methods and materials for their preparation, their use as semiconductors in organic electronic (OE) devices, and to OE devices comprising these polymers.

Abstract: A method for the manufacture of a polymer is provided, the method comprising: Providing a first monomer, the first monomer comprising a bicyclic diamine moiety, a first nucleophilic group provided on a carbon atom of an aromatic moiety, and a second nucleophilic group provided on a carbon atom of an aromatic moiety; Providing a bridging compound comprising at least two sites vulnerable to nucleophilic attack; and Contacting the first monomer with the bridging compound. Polymers made by said method and uses of such polymers are also disclosed.

Abstract: A process is disclosed for preparing a resin-linear organosiloxane block copolymer by reacting a silanol terminated linear organosiloxane and an organosiloxane resin containing hydrolyzable groups to form a resin-linear organosiloxane block copolymer. The resulting resin-linear organosiloxane block copolymer is then crosslinked to sufficiently increase the average molecular weight of the resin-ituted organosiloxane block copolymer by at least 50%. The resin-linear organosiloxanes block copolymers prepared by the disclosed process may provide optically solid compositions which may be considered as “reprocessable.

Abstract: A reactive ionic liquid to be used as an ionic component that is contained in an ion-containing layer in a transducer arranged in contact with a high-resistance layer as a dielectric layer of the transducer, and is restrained from migrating from the ion-containing layer to the high-resistance layer on application of a voltage is provided. The reactive ionic liquid comprises an ion pair that consists of an anion and a cation. In the reactive ionic liquid, (a) the anion comprises (a1) a reactive group that consists of an alkoxysilyl group and (a2) an anionic group consisting of a carboxylate (—COO?) group or a sulfonate (—SO3?) group. (b) The cation (b1) consists of an imidazolium, ammonium, pyrrolidinium, morpholinium, or phosphonium cation, and (b2) does not comprise an N—H group or a P—H group.

Abstract: We disclose a method of making an asphalt composition containing large quantities of ground tire rubber. Over 20% GTR by weight can be used in the asphalt composition without the GTR settling out. The method comprises a series of heating and blending and using a GTR stabilizer.

Abstract: The invention relates to a transparent master mixture that includes an ethylene copolymer and an ethylene monomer having a polar function (a) and a peroxide (b), characterized in that said composition includes, by weight, from 5 to 30% of (b); from 70 to 95% of (a); and in that the copolymer (a) includes from 20 to 45 wt % of ethylene monomer having a polar function. The invention also relates to a method for producing a master mixture composition including an organic peroxide. The method makes it possible to produce a composition useful for cross-linking of polymers.

Abstract: The invention provides a method for the manufacture of a catheter comprising a hydrophilic gel. The method comprising the steps of combining a polymeric photoinitiator of the general formula (I): R1(A1)r-(R2(A2)m-O)o—(R3(A3)n-O)p—R4(A4)s??(I) with one or more gel-forming polymers and/or gel-forming monomers to form a matrix composition, curing the matrix composition by exposing it to UV radiation, exposing the matrix composition to a swelling medium and incorporating the hydrophilic gel into a catheter.

Abstract: A method of producing a metal complex-supporting mesoporous material that can support a metal complex in the pores thereof without causing aggregation of the metal complex. A metal complex-supporting mesoporous material supporting a metal complex in the pores thereof without causing aggregation of the metal complex. A method of producing a mesoporous material supporting metal-containing nanoparticles using the metal complex supported in the pores of the mesoporous material as a template. A solution of a metal complex prepared by a phenyl azomethine dendrimer compound having a specific structure is brought into contact with a mesoporous material so that the metal complex of the phenyl azomethine dendrimer compound is supported by the mesoporous material.

Abstract: This film provides a polyethylene terephthalate film whereby dimensional variation in various steps can be reduced, particularly when the film is used as a substrate film for a flexible device, and that is suitable as a substrate film having minimal curl and excellent appropriateness for processing. This biaxially oriented polyethylene terephthalate film has a degree of crystallinity (Xc) of 0.35 to 0.50, the intrinsic viscosity (IV) of the resin constituting the film is 0.66-1.0 dl/g, the coefficient of thermal expansion at a temperature of 50-170° C. in each of the machine direction and transverse direction of the film is 0.29 ppm/° C., and the degree of thermal shrinkage at 180° C. in each of the machine direction and transverse direction of the film is 0.5%-1.0%.

Abstract: The invention relates to compounds for producing polymethacrylimide foam materials (PMI foams) with particularly good mechanical properties, in particular with a particularly advantageous elongation at tear. The invention further relates to methods for producing, processing, and using said foam materials. In particular, the invention relates to novel materials, the propensity of which to form tears is clearly reduced in comparison to the prior art. This is tantamount to an elongation at tear that is higher in comparison to the prior art.

Abstract: The invention relates to a process for producing expandable pelletized material which comprises polylactic acid which comprises the following steps: a) melting and incorporation by mixing of the following components: i) from 50 to 99.9% by weight, based on the total weight of components i to iii), of polylactic acid, ii) from 0 to 49.9% by weight, based on the total weight of components i to iii), of one or more further polymers, iii) from 0.1 to 2% by weight, based on the total weight of components i to iii), of a diepoxide or polyepoxide, and iv) from 0 to 10% by weight of one or more additives, b) incorporation by mixing of v) from 3 to 7% by weight, based on the total weight of components i to iv), of an organic blowing agent into the polymer melt by means of a static or dynamic mixer at a temperature of at least 140° C., c) discharging through a die plate with holes, the diameter of which at the exit from the die is at most 1.

Abstract: Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising: a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.

Abstract: The present invention relates to organic coloring agents with a high color stability to weathering for thermoplastics. The invention furthermore relates to a polymer composition containing at least one thermoplastic and at least one organic coloring agent, preferably a combination of at least two organic coloring agents, of a specific structure. The invention moreover relates to the use of the coloring agents according to the invention for coloring polymer compositions, in particular for transparent formulations such as are required for the production of panes for use in buildings, motor vehicles and track vehicles or aircraft.

Abstract: This present invention relates to carbon nanotubes as fillers in composites with materials such as elastomers, thermosets and thermoplastics. A further feature of this invention relates to the development of a concentrate of carbon nanotubes with an elastomer wherein the concentrate can be further diluted with an elastomer and other polymers and fillers using conventional melt mixing.

Abstract: The present invention provides a rubber composition that is used for manufacturing a rubber excellent in weather resistance, fracture resistance and crack growth resistance, and that contains a conjugated diene compound/non-conjugated olefin copolymer, a conjugate diene-based polymer and a non-conjugated diene compound/non-conjugated olefin copolymer, a rubber composition for tire side use using the rubber composition for tire sidewall members, a crosslinked rubber composition obtained by crosslinking the rubber composition, and a tire. The rubber composition includes: (A) a conjugated diene compound/non-conjugated olefin copolymer containing a conjugated diene compound-derived unit by at least 40 mol %; (B) a conjugated diene-based polymer; and (C) a non-conjugated diene compound/non-conjugated olefin copolymer containing an ethylene-propylene-diene rubber.

Abstract: The invention relates to a rubber composition and tire with tread thereof containing a functionalized elastomer and reinforcement comprised of rubber reinforcing carbon black and a combination of pre-hydrophobated precipitated silica and at least one of hydrophilic precipitated silica together with at least one of short fibers and resin product of methylene acceptor and methylene donor or hydrophilic precipitated silica having been hydrophobated in situ within the rubber composition by a silica coupling agent, optionally together with at least one of reinforcement additive comprised of short fibers and reinforcement additive comprised of resin product of methylene acceptor and methylene donor.

Abstract: By a method comprising a process including (a) producing a modified conjugated diene polymer through reaction of a conjugated diene polymer having an alkali metal or alkaline-earth metal active terminal with a first alkoxysilane compound which has both an alkoxysilyl group and at least one group convertible into an onium, and (b) mixing the modified conjugated diene polymer, an agent for producing onium, a second alkoxysilane compound having an alkoxysilyl group and at least one group convertible into an onium and a condensation catalyst containing metal element(s) for alkoxysilane compounds, conjugated diene rubber usable as a starting material of cross-linked rubber which is used for a tire tread or the like and allows enhancement of low fuel consumption property can be obtained.

Abstract: A cable comprising a semiconductive layer and an insulation layer with improved DC electrical properties is provided.