Patents Issued in December 15, 2015
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Patent number: 9212378Abstract: A method of amplifying RNA in a sample and a method of amplifying a pool of RNA is provided. Gene loss and amplification bias may be reduced using the methods. Also, directionality may be preserved in the amplified RNA. The methods may be applied in sequence analysis as well as in general molecular diagnostic areas.Type: GrantFiled: April 3, 2013Date of Patent: December 15, 2015Assignee: SAMSUNG ELECTRONICS CO., LTD.Inventors: Ko-bong Choi, Joo-won Rhee, Sea-hee Kim
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Patent number: 9212379Abstract: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.Type: GrantFiled: October 24, 2012Date of Patent: December 15, 2015Assignee: Biogen Idec MA Inc.Inventors: Valerie Liu Tsang, Angela Xiaoying Wang, Helena Yusuf-Makagiansar
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Patent number: 9212380Abstract: A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.Type: GrantFiled: August 30, 2010Date of Patent: December 15, 2015Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.Inventors: Yoshifumi Takahara, Takahiro Nakaminami, Shin Ikeda
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Patent number: 9212381Abstract: Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms. Described herein are robust chemical methods for imaging and affinity-purifying nascent polypeptides in cells and in animals, based on puromycin analogs. Puromycin analogs of the present invention form covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized and specifically captured by a bioorthogonal reaction (e.g., [3+2] cycloaddition). The methods of the present invention have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo.Type: GrantFiled: November 9, 2012Date of Patent: December 15, 2015Assignee: President and Fellows of Harvard CollegeInventors: Adrian Salic, Jing Liu
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Patent number: 9212382Abstract: The present invention relates to an intestinal primary epithelial cell system for detecting gastrointestinal segment-specific activation or suppression of a Toll-like receptor (TLR) by a target agent. The cell system includes an isolated human intestinal primary epithelial cell (HIPEC) line that expresses at least one TLR, where the HIPEC line is derived from a differentiable adult human gastrointestinal stem cell (ahGISC) line. Also disclosed are various methods of using the cell system, a kit that includes the cell system, and an isolated cell culture including an isolated HIPEC line derived from a differentiable ahGISC line.Type: GrantFiled: February 4, 2013Date of Patent: December 15, 2015Assignee: AlfaGene Bioscience, Inc.Inventor: Asit Panja
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Patent number: 9212383Abstract: The present disclosure, according to some embodiments, relates to phage-based biological detection systems, compositions, and methods. In some embodiments, it relates to a detection system and method using phage binding and bacterial infection to detect the presence of a target molecule (e.g., a toxin). One detection system may include a genetically engineered phage that expresses a surface molecule able to bind a target molecule and/or target microorganism; a bacterium susceptible to infection by the phage; and a detection component able to determine whether the bacterium has been infected by the phage. Infection of a bacterium by a phage may be indicative of phage binding to the target molecule and/or target microorganism.Type: GrantFiled: April 4, 2008Date of Patent: December 15, 2015Assignee: GUILD ASSOCIATES, INC.Inventor: David Alexander Schofield
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Patent number: 9212384Abstract: There is provided a microbial culture medium and a microbial culture method for adequately growing a target bacterium contained in an antibacterial test sample. The microbial culture medium for growing a target bacterium contained in an antibacterial test sample is composed of a basal medium for microbial culture, and acid clay or activated clay contained in the basal medium. The microbial culture method for growing a target bacterium contained in an antibacterial test sample using a microbial culture medium includes adding acid clay or activated clay to a solution of the test sample. It is preferred that the acid clay or activated clay be combined with activated carbon.Type: GrantFiled: September 25, 2007Date of Patent: December 15, 2015Assignee: TSUMARA & CO.Inventor: Hiroaki Yamamoto
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Patent number: 9212385Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.Type: GrantFiled: September 12, 2012Date of Patent: December 15, 2015Assignee: Life Technologies CorporationInventors: Robert H. Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
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Patent number: 9212386Abstract: Methods and devices for detecting a target enzyme include an anchored or trapped peptide complex. The peptide complex includes an anchor particle immobilized on a sample analysis device or trapped in a reaction receptacle including a filter, a peptide, with at least one enzyme cleavage site for a target enzyme, bound to the anchor particle, at least one detectable label, and at least one first tag bound to the peptide on a side of the enzyme cleavage site opposite the anchor particle. When the target enzyme is present in the sample, the enzyme cleaves the peptide at the enzyme cleavage site, permitting the cleaved peptide to reach the test zone of a sample analysis device such that the first tag binds to the immobilized second tag and a signal is detected at the test zone.Type: GrantFiled: July 19, 2012Date of Patent: December 15, 2015Assignee: Rapid Pathogen Screening, Inc.Inventors: Uma Mahesh Babu, Robert P. Sambursky, Robert W. VanDine
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Patent number: 9212387Abstract: Provided is a detection kit for detecting target genes of miRNA. Also provided is a method of detecting target genes of miRNA in a simple manner without the need for performing a transfection operation of a gene into cells via a vector. The detection kit is a detection kit for target genes of microRNA, including a cell extraction reagent, and a labeling reagent for microRNA or labeled microRNA, and further including a reaction reagent for the labeling substance for microRNA. mRNA corresponding to target genes of miRNA can be easily pulled down by producing a cell extract under mild conditions, adding labeled miRNA to the cell extract, and recovering the labeling substance. cDNA is produced from the pulled down mRNA to detect target genes of miRNA.Type: GrantFiled: June 15, 2011Date of Patent: December 15, 2015Assignee: National University Corporation Okayama UniversityInventors: Mamoru Ouchida, Sachio Ito
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Patent number: 9212388Abstract: Disclosed herein are methods, compositions and kits for the quantification of a nucleic acid target present on a solid support. This entails quantitative real-time polymerase chain reaction wherein minor groove binders are excluded.Type: GrantFiled: June 30, 2014Date of Patent: December 15, 2015Assignee: LIFE TECHNOLOGIES CORPORATIONInventor: Jason Yingjie Liu
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Patent number: 9212389Abstract: A method of detecting hybridization of complementary segments of nucleic acids by heat generated upon the aforementioned hybridization; a method of detecting the presence of a predetermined reactant in a sample suspected of containing the same, and an apparatus for detecting hybridization of complementary segments of nucleic acids by a heat generated upon aforementioned hybridization, that implements a pyroelectric thermal sensor or a bolometric thermal sensor or a quantum well thermal sensor.Type: GrantFiled: December 16, 2007Date of Patent: December 15, 2015Inventor: Amots Osri
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Patent number: 9212390Abstract: An improved method of in situ hybridization which relies on an improved formulation of the in situ hybridization buffer is described. In at least some formulations the buffer are non-toxic. The combination of Locked Nucleic Acid (LNA) comprising ISH probes and the improved ISH buffer are useful for detection of small non-coding RNA as well as in the manufacturing of ISH kits directed to the detection of such small non-coding RNA. Further disclosed is a method of semi-quantitative ISH and demonstration of the semi-quantitative ISHs diagnostic potential.Type: GrantFiled: April 28, 2011Date of Patent: December 15, 2015Assignee: EXIQON A/SInventors: Boye Schnack Nielsen, Stine Jørgensen, Jan Skouv, Adam Baker, Søren Møller
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Patent number: 9212391Abstract: The present invention relates to a process for determining the DNA integrity in microorganisms and a kit for evaluating the DNA integrity therein. Due to the fact that cell death means DNA fragmentation, with the present process the DNA fragmentation levels in microorganisms can be clearly discriminated in a simple, quick and accurate manner.Type: GrantFiled: July 23, 2013Date of Patent: December 15, 2015Assignee: UNIVERSIDAD AUTONOMA DE MADRIDInventors: Jaime Gosalvez Berenguer, Jose Luis Fernandez Garcia, Vicente Goyanes Villaescusa, German Bau Arevalo, Lourdes Muriel Rios, Monica Cartelle Gestal
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Patent number: 9212392Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.Type: GrantFiled: September 25, 2013Date of Patent: December 15, 2015Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
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Patent number: 9212393Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: May 3, 2011Date of Patent: December 15, 2015Assignee: Life Technologies CorporationInventor: Peter Williams
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Patent number: 9212394Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: January 22, 2015Date of Patent: December 15, 2015Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9212395Abstract: The present invention is directed to novel haplotype tagging single nucleotide polymorphisms (SNPs) in specific regions outside the HFE gene that serve as a reliable biomarker for a decreased risk for childhood lymphoblastic leukemia (ALL) in a child. There is provided herein methods and reagents for assessing the haplotype tagging SNPs selected from the group consisting of rs807212, rs198853, rs9467664, rs2213284, rs2230655 and rs12346. The method useful in applying these SNPs in predicting a decreased risk of childhood lymphoblastic leukemia (ALL) is also disclosed.Type: GrantFiled: February 9, 2010Date of Patent: December 15, 2015Assignee: Medical Diagnostic Laboratories, LLCInventors: Charronne Florence Davis, Mehmet Tevfik Dorak
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Patent number: 9212396Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.Type: GrantFiled: December 19, 2014Date of Patent: December 15, 2015Assignee: The Ohio State UniversityInventor: Carlo M. Croce
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Patent number: 9212397Abstract: Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of Mollicutes. Some oligomers comprise tag regions, target closing regions, promoter sequences, and/or binding moieties. Samples can be from any source suspected of containing a species of the class Mollicutes. Preferred sample sources include bioreactors, cell lines, cell culture wares and pharmaceutical manufacturing wares.Type: GrantFiled: June 23, 2010Date of Patent: December 15, 2015Assignee: GEN-PROBE INCORPORATEDInventors: Shannon K. Kaplan, Kristin W. Livezey, Michael M. Becker, James J. Hogan
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Patent number: 9212398Abstract: The present invention relates to methods of amplification of nucleic acid sequences; more particularly, it relates to methods of amplifying target sequences by utilizing cross priming isothermal amplification. The present invention relates to methods of marking the amplification target sequence during the amplification reaction and rapid detection of the target sequence. The present invention also relates to reagent kits for rapid nucleic acid diagnosis and the nucleic acid detection of pathogenic microorganisms such as bacteria, viruses, as well as to diagnoses related to human genetic diseases.Type: GrantFiled: June 30, 2011Date of Patent: December 15, 2015Inventor: Qimin You
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Patent number: 9212399Abstract: Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. The disclosed compositions safely facilitate rapid sample collection, and provide extended storage and transport of the samples at ambient or elevated temperature without contamination of the sample or degradation of the nucleic acids contained therein. This process particularly facilitates the collection of specimens from remote locations, and under conditions previously considered hostile for presenting the integrity of nucleic acids released from lysed biological samples without the need of refrigeration or freezing prior to molecular analysis.Type: GrantFiled: January 7, 2014Date of Patent: December 15, 2015Assignee: Longhorn Vaccines and Diagnostics, LLCInventors: Gerald W Fischer, Luke T. Daum
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Patent number: 9212400Abstract: The present invention relates to methods for the detection of the presence of swine Torque Teno virus in a sample, for the detection of replication of swine Torque Teno virus in a sample, to Torque Teno virus (RT)-PCR primers and probes, and to diagnostic test kits for the detection of the presence and replication of swine Torque Teno virus in a sample.Type: GrantFiled: May 30, 2012Date of Patent: December 15, 2015Assignee: Intervet Inc.Inventors: Erwin van den Born, Vivian Cornelissen-Keijsers, Tuija Kekarainen, Joaquim Segalés, Laura Martinez-Guinó, Maria Ballester
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Patent number: 9212401Abstract: Fermentable sugar useful for the production of biofuels can be produced from biomass by contacting the biomass with a solution containing at least one ?-hydroxysulfonic acid. The ?-hydroxysulfonic acid can be easily removed from the product and recycled.Type: GrantFiled: March 14, 2013Date of Patent: December 15, 2015Assignee: Shell Oil CompanyInventors: Paul Richard Weider, Robert Lawrence Blackbourn
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Patent number: 9212402Abstract: The present invention provides aqueous flesh coating compositions comprising one or more aqueous acid-functional acrylic or vinyl copolymer and from 0.03 and up to 1.0 equivalent, based on equivalents of carboxylic acid in the polymer, of one or more active compound chosen from an aminoguanidine, semicarbazide, dihydrazide, guanamine, hydrazine and a salt thereof. Further, the invention provides methods of applying the coating composition to leather crust or to tanned leather, and to the flesh coated leather or coated leather crust produced thereby. The leather crust and tanned leather produced by the invention, for example fleshcoated or finished leather, will emit greatly reduced levels of aldehydes over time and especially valuable in scrubbing aldehydes from perforated leather for automotive use.Type: GrantFiled: September 11, 2009Date of Patent: December 15, 2015Assignee: Rohm and Haas CompanyInventors: Anton G. El A'mma, Robert W. Grich, Joseph M. Hoefler, Kelley L. Klein, Jill A. Ottinger
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Patent number: 9212403Abstract: Provided is a natural leather having a novel coating layer which feels leathery. The coating film retains material properties such as strength and wearing resistance. When the user directly touches the natural leather, the coating layer present on the surface of the natural leather gives slick characteristics of natural leathers and smoothness. The natural leather has a coating film formed on a surface thereof, the coating film including: a color coat layer formed from a mixture of a hard component (10% modulus is more than 2.3 but no more than 3.0) and a soft component (10% modulus is more than 0.0 but no more than 1.0) of a two-component polyurethane resin; and a topcoat layer formed from a mixture of a medium component (resin having a 10% modulus of more than 1.0 but no more than 2.3) and a soft component (resin having a 10% modulus of more than 0.0 but no more than 1.0) of a two-component polyurethane resin.Type: GrantFiled: May 15, 2009Date of Patent: December 15, 2015Assignees: Midori Hokuyo Co., Ltd., Honda Motor Co., Ltd.Inventors: Shinji Kashiwagura, Masahiko Ogawa, Takashi Ono, Miwa Tada, Yoshiyuki Ito, Masato Ishibashi, Takashi Yamaguchi
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Patent number: 9212404Abstract: The invention relates to a preparation method for stainless steel slags and modified steelworks slags for recovery of metal. In order to create a dry preparation method which guarantees a low wear and energy efficient comminution and de-agglomeration of stainless steel slags and modified steelworks slags as well as a selective separation of a metal fraction and a silicate fraction and which can be variable in relation to the different slag compositions and different requirements upon the quality of the metal fraction and the at least one silicate fraction, a roller mill is used at least for the comminution. The slags are supplied with a feed grain size of up to approximately 150 mm. The use of an air swept roller mill is advantageous, in which the comminution and de-agglomeration, if necessary drying, and at the same time a separation into an extensively mineral-free metal fraction and a virtually metal-free silicate fraction are brought together.Type: GrantFiled: November 11, 2010Date of Patent: December 15, 2015Assignee: LOESCHE GmbHInventors: Carsten Gerold, Frank Dardemann, Joerg Langel, Holger Wulfert
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Patent number: 9212405Abstract: The present invention provides a wire rod with a composition at least including: C: 0.95-1.30 mass %; Si: 0.1-1.5 mass %; Mn: 0.1-1.0 mass %; Al: 0-0.1 mass %; Ti: 0-0.1 mass %; P: 0-0.02 mass %; S: 0-0.02 mass %; N: 10-50 ppm; O: 10-40 ppm; and a balance including Fe and inevitable impurities, wherein 97% or more of an area in a cross-section perpendicular to the longitudinal direction of the wire rod is occupied by a pearlite, and 0.5% or less of an area in a central area in the cross-section and 0.5% or less of an area in a first surface layer area in the cross-section are occupied by a pro-eutectoid cementite.Type: GrantFiled: May 21, 2013Date of Patent: December 15, 2015Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Shingo Yamasaki, Toshiyuki Manabe, Daisuke Hirakami, Nariyasu Muroga
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Patent number: 9212406Abstract: Provided is a method for improving the recovery rate of valuable metals such as cobalt when drying the battery waste of lithium ion batteries and the like. A second alloy excellent in terms of iron-cobalt separation performance and containing a small amount of iron is obtained by performing: a pre-oxidation step (ST20) for roasting and pre-oxidizing battery waste containing aluminum and iron; a melting step (ST21) for obtaining a molten product by melting the battery waste after the pre-oxidation step; a first slag separation step (ST22) for separating and recovering first slag containing aluminum oxide from the molten product; a second oxidation step (ST23) for oxidizing a molten first alloy after the first slag separation step; and a second slag separation step (ST24) for separating and recovering a second slag containing iron from a second alloy after the second oxidation step (ST23).Type: GrantFiled: February 15, 2012Date of Patent: December 15, 2015Assignee: SUMITOMO METAL MINING CO., LTD.Inventors: Jun-ichi Takahashi, Kazuhiro Mori, Toshirou Tan
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Patent number: 9212407Abstract: A process by which molten solder is purified in-situ, making the soldering process more efficient and yielding better results, particularly for lead-free soldering. Lead-free solder becomes practical for use since the temperature for reliable soldering is reduced. A layer of active additive is maintained on the surface of molten solder for scavenging metal oxide from the solder and assimilating metal oxide into a liquid layer. The active additive is an organic liquid having nucleophilic and/or electrophilic groups. As an example, a layer of dimer acid maintained on a wave soldering apparatus scavenges metal oxide from the bath, and assimilates dross that may form on the surface. Scavenging metal oxide cleanses the bath and lowers viscosity of the solder, and PC boards or the like soldered on the wave have reliable solder joints.Type: GrantFiled: November 18, 2013Date of Patent: December 15, 2015Assignee: MS2 Technologies, LLCInventors: Lawrence C. Kay, Erik J. Severin, Luis A. Aguirre
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Patent number: 9212408Abstract: A decorative part comprising a hardening layer having a pink Au alloy coating film on a surface of the part. The hardening layer is obtainable by laminating a base layer, a primary layer and a finishing layer from the side of a substrate. The base layer comprises a metal layer comprising one metal or two or more metals selected from Hf, Ti and Zr and, superimposed thereon, a compound layer comprising the same metal constituting the metal layer and further comprising nitrogen, carbon or oxygen. The primary layer has a laminating structure such that an Au alloy layer, and a compound layer comprising one metal or two or more metals selected from Hf, Ti and Zr and further comprising nitrogen, carbon or oxygen are laminated one after the other. The finishing layer comprises an Au alloy layer.Type: GrantFiled: September 18, 2008Date of Patent: December 15, 2015Assignee: CITIZEN HOLDINGS CO., LTD.Inventors: Junji Satoh, Yoshitsugu Shibuya, Maki Hayakawa, Ryota Koike
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Patent number: 9212409Abstract: A mixture of powders for preparing a sintered nickel-titanium-rare earth (Ni—Ti—RE) alloy includes Ni—Ti alloy powders comprising from about 55 wt. % Ni to about 61 wt. % Ni and from about 39 wt. % Ti to about 45 wt. % Ti, and RE alloy powders comprising a RE element.Type: GrantFiled: January 18, 2013Date of Patent: December 15, 2015Assignees: Cook Medical Technologies LLC, University of LimerickInventors: Syed A. M. Tofail, James Butler, James M. Carlson, Garry Warren, Abbasi A. Gandhi, Peter Tiernan
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Patent number: 9212410Abstract: The present invention inexpensively provides with high productivity and good yield a steel rod superior in drawability and a steel wire superior in twistability using the same as a material, that is, draws a high strength steel rod superior in ductility where the chemical components contain C: 0.80 to 1.20%, Si: 0.1 to 1.5%, Mn: 0.1 to 1.0%, Al: 0.01% or less, Ti: 0.01% or less, one or both of W: 0.005 to 0.2% and Mo: 0.003 to 0.2%, N: 10 to 30 ppm, B: 4 to 30 ppm (of which, solute B is 3 ppm or more), and O: 10 to 40 ppm, which has a balance of Fe and unavoidable impurities, has an area percentage of pearlite structures of 97% or more, has a balance of non-pearlite structures, and has a total of the area percentage of the non-pearlite structures and the area percentage of the coarse pearlite structures of 15% or less, to obtain high strength steel wire superior in ductility having a tensile strength of 3600 MPa or more and a number density of voids of lengths of 5 ?m or more at the center of 100/mm2 or less.Type: GrantFiled: March 9, 2009Date of Patent: December 15, 2015Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Shingo Yamasaki, Seiki Nishida
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Patent number: 9212411Abstract: A high-strength steel sheet includes a composition containing, in mass percent, 0.08% to 0.20% of carbon, 0.2% to 1.0% of silicon, 0.5% to 2.5% of manganese, 0.04% or less of phosphorus, 0.005% or less of sulfur, 0.05% or less of aluminum, 0.07% to 0.20% of titanium, and 0.20% to 0.80% of vanadium, the balance being iron and incidental impurities.Type: GrantFiled: June 29, 2010Date of Patent: December 15, 2015Assignee: JFE Steel CorporationInventors: Koichi Nakagawa, Takeshi Yokota, Kazuhiro Seto, Satoshi Kinoshiro, Yuji Tanaka, Katsumi Yamada, Tetsuya Mega, Katsumi Nakajima
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Patent number: 9212412Abstract: The present invention provides a lean duplex stainless steel able to suppress the drop in corrosion resistance and toughness of a weld heat affected zone comprising, by mass %, C: 0.06% or less, Si: 0.1 to 1.5%, Mn: 2.0 to 4.0%, P: 0.05% or less, S: 0.005% or less, Cr: 19.0 to 23.0%, Ni: 1.0 to 4.0%, Mo: 1.0% or less, Cu: 0.1 to 3.0%, V: 0.05 to 0.5%, Al: 0.003 to 0.050%, O: 0.007% or less, N: 0.10 to 0.25%, and Ti: 0.05% or less, having a balance of Fe and unavoidable impurities. An Md30 value is 80 or less, an Ni-bal is ?7.1 to 4, an austenite phase area percentage is 40 to 70%, and a 2×Ni+Cu is 3.5 or more: Md30=551?462×(C+N)?9.2×Si?8.1×Mn?29×(Ni+Cu)?13.7×Cr?18.5×Mo?68×Nb; Ni-bal=(Ni+0.5Mn+0.5Cu+30C+30N)?1.1(Cr+1.5Si+Mo+W)+8.2 and N(%)?0.37+0.03×(Ni-bal).Type: GrantFiled: March 26, 2009Date of Patent: December 15, 2015Assignee: NIPPON STEEL & SUMIKIN STAINLESS STEEL CORPORATIONInventors: Yuusuke Oikawa, Hiroshi Urashima, Shinji Tsuge, Hiroshige Inoue, Ryo Matsuhashi
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Patent number: 9212413Abstract: A metal matrix ceramic composite is completely formed by permeating at least part of a matrix metal into an array of ceramic granules by squeeze-casting, and the volume percentage of the ceramic granules may be adjusted within a range of 10%-80% of the metal matrix ceramic composite according to the usage requirements. The metal matrix ceramic composites not only retain high performance of anti-penetration, but also have the strong toughness of the metal; in addition, this composite has features of low density, resistance against ordinary mechanical cutting and flame cutting, and inhibition of crack propagation and the like. The composite has broad application prospects in the protection of such important security facilities as safes, automatic teller machines and vault gates.Type: GrantFiled: March 28, 2013Date of Patent: December 15, 2015Assignee: CHINA WEAPON SCIENCE ACADEMY NINGBO BRANCHInventors: Jinhua Wang, Bo Yang, Zhiyuan Xing, Xiurong Zhu, Shunqi Zheng, Ying Wang, Juan Lv, Zhaohui Gong, Liqun Hou
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Patent number: 9212414Abstract: A meniscus coating apparatus and method for coating at least one surface of a metal strip includes an apparatus having an adjustable coating tray, a roll enclosure disposed adjacent the coating tray, an adjustable baffle, and/or a gas delivery device operable to help seal the roll enclosure.Type: GrantFiled: May 24, 2012Date of Patent: December 15, 2015Assignee: AK Steel Properties, Inc.Inventors: Larry E. Parrella, Paul V. Janavicius, George A. Paraskos
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Patent number: 9212416Abstract: Low temperature carburization of stainless steel using acetylene as the carburizing specie is carried out under soft vacuum conditions in the presence of hydrogen or other companion gas. As a result, formation of soot and the undesirable thermal oxide film that normally occurs during low temperature carburization is eliminated virtually completely.Type: GrantFiled: August 5, 2010Date of Patent: December 15, 2015Assignee: Swagelok CompanyInventors: Peter C. Williams, Sunniva R. Collins, Steven V. Marx
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Patent number: 9212417Abstract: Certain example embodiments of this invention relate to a coated article including a low-E coating. In certain example embodiments, a titanium oxide inclusive bottom layer stack and/or a NiCr-based layer(s) are designed to improve b* coloration values and/or transmission of the coated article. These layer stack portions also are advantageous in that they permit a double-silver coated article to achieve (i) an LSG value (Tvis/SHGC) of at least 2.0, (ii) an SHGC value of no greater than 35%, more preferably no greater than 33, 32 or 30%, and (iii) a U-value (BTU h?1 ft?2 ° F.?1) (e.g., x=12 mm) of no greater than 0.30, more preferably no greater than 0.28 or 0.25. In certain example embodiments, the titanium oxide based layer may be an interlayer provided in a bottom portion of the layer stack between first and second layers comprising silicon nitride.Type: GrantFiled: May 1, 2014Date of Patent: December 15, 2015Assignee: Guardian Industries Corp.Inventors: Marcus Frank, Nancy Bassett, Bryce Corsner
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Patent number: 9212418Abstract: The invention relates to an Al—Ni—La system Al-based alloy sputtering target where a total area of an Al—Ni system intermetallic compound having an average particle diameter of 0.3 ?m to 3 ?m with respect to a total area of the entire Al—Ni system intermetallic compound is 70% or more in terms of an area fraction, and a total area of an Al—La system intermetallic compound having an average particle diameter of 0.2 ?m to 2 ?m with respect to a total area of the entire Al—La system intermetallic compound is 70% or more in terms of an area fraction.Type: GrantFiled: October 31, 2007Date of Patent: December 15, 2015Assignees: Kobe Steel, Ltd., KOBELCO RESEARCH INSTITUTE, INC.Inventors: Masaya Ehira, Katsutoshi Takagi, Toshihiro Kugimiya, Yoichiro Yoneda, Hiroshi Gotou
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Patent number: 9212419Abstract: A copper alloy wiring film of a flat panel display of the present invention and a sputtering target for forming the same have a composition including Mg: 0.1 to 5 atom %; either one or both of Mn and Al: 0.1 to 11 atom % in total; and Cu and inevitable impurities as the balance, and if necessary, may be further including P: 0.001 to 0.1 atom %.Type: GrantFiled: July 31, 2009Date of Patent: December 15, 2015Assignee: MITSUBISHI MATERIALS CORPORATIONInventors: Kazunari Maki, Kenichi Yaguchi, Yosuke Nakasato, Haruhiko Asao
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Patent number: 9212420Abstract: A chemical vapor deposition (CVD) method for depositing a thin film on a surface of a substrate is described. The CVD method comprises disposing a substrate on a substrate holder in a process chamber, and introducing a process gas to the process chamber, wherein the process gas comprises a chemical precursor. The process gas is exposed to a non-ionizing heat source separate from the substrate holder to cause decomposition of the chemical precursor. A thin film is deposited upon the substrate.Type: GrantFiled: March 23, 2010Date of Patent: December 15, 2015Assignee: Tokyo Electron LimitedInventors: Eric M. Lee, Raymond Nicholas Vrtis, Mark Leonard O'Neill, Patrick Timothy Hurley, Jacques Faguet, Takashi Matsumoto, Osayuki Akiyama
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Patent number: 9212421Abstract: A method and fluidized bed reactor for reducing or eliminating contamination of silicon-coated particles are disclosed. The metal surface of one or more fluidized bed reactor components is at least partially coated with a hard protective layer comprising a material having an ultimate tensile strength of at least 700 MPa at 650° C.Type: GrantFiled: July 10, 2013Date of Patent: December 15, 2015Assignee: REC Silicon IncInventors: Matthew J. Miller, Michael V. Spangler
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Patent number: 9212422Abstract: A chemical vapor deposition reactor has one or more deposition zones bounded by gas flow virtual walls, within a housing having closed walls. Each deposition zone supports chemical vapor deposition onto a substrate. Virtual walls formed of gas flows laterally surround the deposition zone, including a first gas flow of reactant gas from within the deposition zone and a second gas flow of non-reactant gas from a region laterally external to the deposition zone. The first and second gas flows are mutually pressure balanced to form the virtual walls. The virtual walls are formed by merging of gas flows at the boundary of each deposition zone. The housing has an exhaust valve to prevent pressure differences or pressure build up that would destabilize the virtual walls. Cross-contamination is reduced, between the deposition zones and the closed walls of the housing or an interior region of the housing outside the gas flow virtual walls.Type: GrantFiled: August 31, 2011Date of Patent: December 15, 2015Assignee: Alta Devices, Inc.Inventors: Gregg Higashi, Alexander Lerner, Khurshed Sorabji, Lori D. Washington
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Patent number: 9212423Abstract: Steel sheet for container use with excellent canmaking workability and with excellent drawability and ironability, weldability, corrosion resistance, coating adhesion, film adhesion, and wettability characterized in that a surface of the steel sheet has a Zr film which contains, by amount of metal Zr, 1 to 100 mg/m2 of Zr oxides.Type: GrantFiled: June 4, 2010Date of Patent: December 15, 2015Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Akira Tachiki, Shigeru Hirano, Hirokazu Yokoya
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Patent number: 9212424Abstract: The present disclosure is directed to an apparatus and method of sintering inorganic powder coatings on substrates, and includes a flame and an electric plasma. The method is capable of being used in an open atmospheric environment. The substrate is electrically conductive and is used as one electrode while the flame is used as the other electrode that is moved over the areas of the powder coating to be sintered. An electrical current is used to cause a plasma produced through the flame, resulting in a combined energy and temperature profile sufficient for inorganic powder-powder and powder-substrate bonding. This method is referred to as “flame-assisted flash sintering” (FAFS).Type: GrantFiled: May 26, 2015Date of Patent: December 15, 2015Assignee: nGimat Co.Inventors: Andrew Tye Hunt, Stephen Johnson, Ganesh Venugopal
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Patent number: 9212425Abstract: The invention relates to an object comprising a relatively soft carrier material, optionally, an adhesive layer and/or an adhesive layer system, which are applied to the carrier material, and a relatively hard decorative layer. The object is characterized in that an intermediate layer is provided between the carrier material and the decorative layer and/or between the adhesive layer and the adhesive layer system and the decorative layer and comprises at least DLC (diamond like carbon) as the main component. The invention also relates to a method for producing said type of object.Type: GrantFiled: January 5, 2007Date of Patent: December 15, 2015Assignee: IHI HAUZER TECHNO COATING B.V.Inventors: Michiel Eerden, Jeroen Landsbergen, Paul Peeters, Christian Strondl, Roel Tietema
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Patent number: 9212426Abstract: A rust preventive oil composition containing a first mineral oil that is a mineral oil having a kinematic viscosity at 40° C. of 6 mm2/s or less, a second mineral oil that is a mineral oil having a kinematic viscosity at 40° C. of 250 mm2/s or more, a fatty acid amine salt, an ester, and one or more rust preventive agents selected from the group consisting of a sarcosine-type compound, a nonionic surfactant, a sulfonic acid salt, an amine, a carboxylic acid, a fatty acid amine salt, a carboxylic acid salt, a paraffin wax, an oxidized wax salt, and a boron compound.Type: GrantFiled: October 29, 2012Date of Patent: December 15, 2015Assignee: JX NIPPON OIL & ENERGY CORPORATIONInventors: Junichi Shibata, Koichi Yoshida, Tadaaki Motoyama
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Patent number: 9212427Abstract: The invention relates to a cyanide-free electrolyte composition for depositing a silver or silver alloy layer on a substrate as well as a method for depositing such layers with the help of said cyanide-free electrolyte composition. The electrolyte composition according to the invention comprises at least one silver ion source, a sulfonic acid and/or a sulfonic acid derivative, a wetting agent and a hydantoin. The silver or silver alloy layers deposited from such an electrolyte composition by means of the method according to the invention are dull and ductile.Type: GrantFiled: October 9, 2007Date of Patent: December 15, 2015Assignee: Enthone Inc.Inventors: Stefan Schäfer, Thomas B. Richardson
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Patent number: 9212428Abstract: The present invention provides a steel sheet for a container including a cold-rolled steel sheet and a composite film formed on the cold-rolled steel sheet through an electrolysis process in a solution containing: at least one metal ion of an Sn ion, an Fe ion, and an Ni ion; Zr ion; a nitric acid ion: and an ammonium ion, in which the composite film contains at least one element of: Zr of 0.1 to 100 mg/m2 in equivalent units of metal Zr; Sn of 0.3 to 20 g/m2 in equivalent units of metal Sn; Fe of 5 to 2000 mg/m2 in equivalent units of metal Fe; and Ni of 5 to 2000 mg/m2 in equivalent units of metal Ni.Type: GrantFiled: June 28, 2011Date of Patent: December 15, 2015Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Shigeru Hirano, Akira Tachiki, Hirokazu Yokoya, Morio Yanagihara, Makoto Kawabata