Abstract: An applanation tonometer for measuring intraocular pressure (IOP) so that the health of a human or animal eye can be determined. The applanation tonometer includes a prism having a contact tip at one end to be moved into contact with and lightly touched against the cornea or the eye. Incident laser light is transmitted inwardly through the prism to the contact tip at which some of the light is decoupled and lost though the contact tip depending upon the area of contact between the contact tip and the cornea. The remaining light is reflected by the contact tip outwardly through the prism. A photo defector which is responsive to the light reflected by the contact tip of the prism and a force detector which is responsive to the pressure at the area of contact between the contact tip and the cornea generate paired force and area data pairs that are processed to measure IOP.

Abstract: A structure for wireless communication having a plurality of conductor layers, an insulator layer separating each of the conductor layers, and at least one connector connecting two of the conductor layers wherein an electrical resistance is reduced when an electrical signal is induced in the resonator at a predetermined frequency.

Abstract: A remote patient management system comprising a display and a processor. Execution of instructions cause the processor to: determine at least one first boundary value between a safe zone and a warning zone for each of at least one patient vital sign; determine at least one second boundary value between the warning zone and an alert zone for each of the at least one patient vital sign; repeatedly receive the at least one patient vital sign; determine a status value indicating the safe zone, warning zone, or alert zone; calculate a transition risk value; and display a patient status indicator which indicates the status level and the transition risk.

Abstract: Disclosed is a method for interpreting image data that represents variations in density of matter inside a subject. A data processing system receives image data from a scan of a subject. The data processing system automatically discerns one or more bones, one or more arteries, and one or more organs of the subject, based at least in part on the image data. The data processing system may also automatically identify one or more of the discerned bones, arteries, and organs. The data processing system may also automatically determine a branch point of one of the one or more arteries of the subject. The data processing system may also produce output that depicts one or more of the identified bones, one or more of the identified arteries, one or more of the identified organs, and/or or the outer or inner margin of the body wall. Other embodiments are described and claimed.

Abstract: The present disclosure provides various systems and methods for focusing electromagnetic radiation (EMR) within a diffusion medium, such as a turbid medium. A diffusion medium is irradiated with EMR. The EMR may be modulated by an acoustical wave focused on a focus volume within the diffusion medium. The EMR may be modulated by a beat frequency or other function of multiple focused acoustical waves. The EMR may be modulated at a harmonic of a fundamental frequency of one or more acoustical waves. A filter may filter the emerging EMR to remove all but specifically modulated EMR scattered from the focus volume. The modulated EMR may be focused and/or used for various purposes, including imaging. In some embodiments, the modulated EMR may be reflected and/or amplified by a phase conjugating mirror. Furthermore, in some embodiments, acoustical phase conjugation may be used to focus an acoustical wave on a focus volume.

Abstract: Devices and methods for improving the sensitivity and specificity of heart failure (HF) detection are described. The devices and methods can detect a HF status such as using physiological sensor data and external biomarker assays. An apparatus can comprise ambulatory physiological sensors that can provide a first HF status indicator and a second HF status indicator to a user. An external biomarker sensor can provide an amount of a biomarker present, such as an assay for B-type natriuretic peptide (BNP), which provides information about HF status. A processor circuit can switch from a first HF detection mode to a second detection mode such as in response to the information from the biomarker sensor. The first detection mode can detect HF status using the first HF status indicator, and the second detection mode can detect HF status using the second HF status indicator. The second detection mode can have a higher specificity than the first detection mode.

Abstract: The disclosure describes systems, methods, and apparatus providing detection mechanism for lead-related conditions, including transient behaviors, on a conductive pathway of a medical electrical lead. In one example, a sense path arbitration module identifies a lead-related condition associated with a conductive pathway based on signal processing to identify transients emerging from a propagated signal. The sense path arbitration module may evaluate a plurality of conductive pathways of the medical electrical lead and arbitrates propagation of a sensed signal that is transmitted through the plurality of lead conductors based on the evaluation. Therapy delivery functions utilizing the medical electrical lead may also be controlled in response to the signal processing and identification of the lead-related condition on a conductive pathway.

Abstract: A measurement device pressurizes two cuffs in a state in which the cuffs are attached to the distal side and the proximal side of the measurement device, respectively, calculates an AI value or the like based on a pulse wave detected from a change in cuff pressure on the distal side while pressurizing the two cuffs, and determines that avascularization on the distal side has been completed if the AI value or the like has converged. Once it is determined that avascularization has been completed, the cuff pressure on the distal side is fixed, and a pulse wave is detected from a change in cuff pressure on the proximal side in a state in which the distal side is avascularized.

Abstract: A system and method for providing diagnosis and monitoring of congestive heart failure for use in automated patient care is described. At least one recorded physiological measure is compared to at least one other recorded physiological measure on a substantially regular basis to quantify a change in patient pathophysiological status for equivalent patient information. An absence, an onset, a progression, a regression, and a status quo of congestive heart failure is evaluated dependent upon the change in patient pathophysiological status.

Abstract: An apparatus and method for automatically identifying FHR baseline includes collecting FHR data within a preset duration to obtain an FHR data sequence h?(n); preprocessing the collected FHR data sequence h?(n) to obtain a corresponding FHR data sequence during the preprocessing; selecting a primary dominant peak value according to the frequency distribution of the corresponding FHR data sequence during the preprocessing; and identifying a dynamic baseline according to the corresponding FHR data sequence and the primary dominant peak value during the preprocessing to obtain the dynamic baseline, and display and print the dynamic baseline. The apparatus and method effectively prevents the impact caused by regular change of the FHR to the baseline solution, and accurately reflects the FHR baseline and changes thereof of a fetus under different conditions.

Abstract: An amplifier circuit includes first and second amplification units. A first detection electrode and a high impedance circuit are connected to the input terminal of the first amplification unit. A second detection electrode and a high impedance circuit are connected to the input terminal of the second amplification unit. The output terminals of the first and second amplification units output first and second output signals, and are connected to the input terminals of a differential amplifier circuit through coupling capacitors, respectively. The differential amplifier circuit operates a difference between the first and second output signals in a state where a direct-current component is omitted.

Abstract: An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.

Abstract: In an electroencephalogram recording apparatus: a classification section classifies a collected sound into one of categories concerning sound pressure; an accumulation determination section determines whether or not to record an electroencephalogram of a user based on whether a number of times of data accumulation has reached a target value for the category into which the sound is classified; and an accumulation section accumulates an electroencephalogram data and a sound data in association if the electroencephalogram data is determined to be recorded. A first value is designated as a target value for a first category into which sounds of an expected minimum value are classified. A second value is designated as a target value for a second category into which any sound having a sound pressure greater than the minimum value is classified. The accumulation determination section sets the first value to be equal to or greater than the second value.

Abstract: An uncomfortable sound pressure estimation system includes: a biological signal measurement section for measuring an electroencephalogram signal of a user; a sound stimulation output section for presenting a sound stimulation group to the user, the sound stimulation group including a first sound, a second sound, and a third sound which are pure tones of the same frequency and which consecutively decrease in sound pressure within a predetermined range; an extraction section for, from the electroencephalogram signal in a predetermined zone defined based on a point of presenting at least one of the second sound and the third sound as a starting point, extracting an N1-P2-amplitude related or wavelet-coefficient related characteristic amount of event-related potential of the electroencephalogram signal; and a determination section for determining an uncomfortable sound pressure at the frequency of the sound stimulation group based on the characteristic amount extracted by the extraction section.

Abstract: An electromagnetic pedicle awl utilizes a tightly focused time-varying magnetic flux to create a localized electromotive force (EMF) near the tip. The localized EMF creates localized eddy currents in nearby nerves which excite ionic nerve channels, the excitation being detected by an electromyographic recording device. The awl only excites nerves directly in front of and directly to the side of the tip. The awl is comprised of a tapered awl or drill tip in combination with a solid core surrounded by a solenoid. A pulsed electric current source drives the solenoid to create a time-varying magnetic field in the vicinity of the tapered tip. The awl or drill tip may be stationary with respect to the solenoid or it may rotate. The awl in combination with an EMG detector connected to a patient is sensitive to the pedicle hole position with respect to adjacent nerves and reduces false placement failure.

Abstract: Exemplary embodiments of method, system and computer-accessible medium according to the present disclosure can be provided for converting magnetic resonance (MR) arterial signal intensity versus time curves to arterial input functions (AIF) with less susceptibility to artifacts such as flow-related enhancement. Exemplary methods, systems and computer-accessible medium can be used to constrain AIF to satisfies the indicator dilution principle, according to which the area under an initial pass component of AIF can be equal to the injected dose divided by the cardiac output. For example, Monte Carlo simulations of MR renography and tumor perfusion protocols can be performed for comparison with conventional methods.

Abstract: According to a Magnetic Resonance Imaging (MRI) apparatus, a scanning-parameter limit calculating unit creates examination information that represents scanning conditions for collection of magnetic resonance signal data based on scanning parameters set by an operator; a scanning-condition edit/scan positioning unit creates a time chart that indicates the type and a sequential execution order of an event to be executed when collecting magnetic resonance signal data based on the examination information created by the scanning-parameter limit calculating unit, and causes a time-chart display unit to display the created time chart.

Abstract: The invention provides methods and systems for determining the position of a remote object such as an in vivo medical device such as capsule or probe within a medical patient. Integrated computer and computer executable remote permanent magnetic dipole position and orientation detection system monitors remote object movement. User interface displays remote permanent magnetic dipole location and orientation in a 3-dimensional view. Database stores object position movement in association with time. Magnetic sensor planes detect remote objects with permanent magnetic dipole and generate magnetic field information signal. Computer stores and searches location and posture information use a file.

Abstract: Disclosed herein is a method and apparatus for monitoring, identifying and determining the breathing cycle of an individual from processed acoustic signal waveform data. The breathing sounds of an individual are recorded using a microphone and digitized such that the breathing sounds may be plotted. The data is segmented and transformed to form a plurality of segments representative of a frequency spectrum. The frequency spectrum data is transformed so as to produce magnitude bins and the sum of lower magnitude bins and the sum of higher magnitude bins are determined in a sampling of segments. A Bands Ratio is determined from the sum of lower magnitude bins and the sum of higher magnitude bins in the sampling of segments. A first bands ratio is then determined within a given segment and compared to the mean bands ratio. If the first bands ratio of the given segment is greater than the mean bands ratio by at least a predetermined multiplier, the given segment is labeled as inspiration.

Abstract: Systems and methods for analyzing the gait of an individual are disclosed. The disclosed systems and methods can be configured to acquire data from a first array and a second array of sensors that are configured to be placed in a left and/or right shoe, respectively. The acquired data can be collected or separated into at least two separate gait phases for each array, compared to a baseline condition for each gait phase and categorized into one of at least two uniformity categories for each gait phase. Examples of collected and/or calculated data include pressure values, shear stress values and torque values. The analysis can be focused on both feet of a person, or focused on one foot. A graphical output showing at least one entire gait cycle based on the uniformity categories can then be generated.

Abstract: A system and method for measuring the movement of one or more limbs of an infant using a video system for the purpose of determining whether the infant suffers from or is at risk of suffering from a medical condition such as cerebral palsy.

Abstract: A method to reduce DPOAE fine structure in the measurement of DPOAE acoustic signals generated in the cochlea in response to two primary tones.

Abstract: The present disclosure relates to an indwelling catheter having a cannula device (2, 4) and a reservoir, which is connected in a use position to the cannula device (2, 4), such that blood can flow from the cannula device (2, 4) into the reservoir (6), wherein the housing (3) has housing identifiers (8) and the reservoir (6) has reservoir identifiers (9), and the housing identifiers (8) and the reservoir identifiers (9) give mutually assigned codes. In addition, the disclosure relates to a transfusion cannula kit and the method for testing a transfusion system.

Abstract: A method 1300 and apparatus for deriving a health index for determining cardiovascular health of a person is disclosed herein. In a described embodiment, the method 1300 includes (i) obtaining values of respiratory rate, Sp02 and heart rate from a PPG signal of the person at step 1304; (ii) assigning a score based on the values from a reference scoring system at step 1306; and (iii) deriving the health index based on the assigned scores at step 1308/1314. A method and device for obtaining the PPG signal at optimum pressure is also disclosed.

Abstract: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.

Abstract: A system evaluates a patient for a physiological abnormality. A urinary catheter is insertable within a patient's bladder and has a first pressure sensor for measuring bladder pressure and a second pressure sensor for measuring mid-urethral pressure at the mid-urethral sphincter. A processing device is connected to the first and second pressure sensors and configured to receive the measured bladder pressure and measured mid-urethral pressure during at least one breath cycle and process the data representative of the bladder and mid-urethral pressures obtained during the at least one breath cycle to diagnose a physiological abnormality within the patient.

Abstract: An image display apparatus includes a display section (display unit) that displays an image, an information acquisition section that acquires predominance levels of sympathetic nerves and parasympathetic nerves and an activity magnitude of the autonomic nerves based on the biological information, an image generation section that generates the biological state image in which a figure having a size according to the acquired activity magnitude of the autonomic nerves is set along a first axis, along one side of which the predominance level of the sympathetic nerves is set with respect to a reference point and along the other side of which the predominance level of the parasympathetic nerves is set with respect to the reference point, in a position according to the acquired predominance levels of the sympathetic nerves and the parasympathetic nerves.

Abstract: A craniosynostosis detection system is disclosed that may comprise a movement detection apparatus configured to detect movement in a surface of the scalp of the patient along areas between bones of the skull when at least a portion of the movement detection apparatus is positioned adjacent to the surface of the scalp. The movement detection apparatus may generate a signal corresponding to movement detected by the movement detection apparatus. A signal processing apparatus may be operatively connected to the movement detection apparatus and configured to receive the movement signal from the movement detection apparatus. A data display apparatus may be operatively connected to the signal processing apparatus and configured to display a representation of movement detected by the movement detection apparatus. The absence of movement of the scalp over the sutures, which correspond to the brain pulsations, is diagnostic of craniosynostosis.

Abstract: A system and method of use for a probe is disclosed that includes a self-expanding housing constructed to permit fluid flow therethrough and constructed for insertion into a subject to be imaged. A plurality of RF coils is attached to the housing to acquire MR data.

Abstract: A system and method for intracranial access is disclosed. In particular, a drill stop is shown providing a way to control the penetration of a drill bit as an access hole into the brain is being formed. Access to a desired location is achieved using a catheter guide device. Also disclosed is a mechanism by which multiple diagnostic and treatment devices can be placed at a desired location in brain tissue without the need for more than one access hole. A drainage catheter is disclosed with a mechanism to allow both drainage and to allow intracranial pressure measurement.

Abstract: A method and system for a user interface for artifact removal in an EEG is disclosed herein. The invention allows an operator to select a plurality of artifacts to be automatically removed from an EEG recording using a user interface. The operator pushes a button on the user interface to apply a plurality of filters to remove the plurality of artifacts from the EEG and generate a clean EEG for viewing.

Abstract: Disclosed herein is an X-ray imaging apparatus. The X-ray imaging apparatus includes at least one X-ray emitter which is configured to irradiate an object with X-rays at a plurality of X-ray emission positions, an X-ray detector which is configured to detect X-rays which are emitted by the X-ray emitter and to convert the detected X-rays into an electric signal, and an image processor which is configured to acquire a plurality of original X-ray images which respectively correspond to the X-ray emission positions from the generated electric signal and to estimate a virtual X-ray image which is acquirable at an X-ray emission position located between at least two of the plurality of X-ray emission positions, based on at least two of the original X-ray images.

Abstract: A method, system, and program product are provided for x-ray pose recovery during an endoscopic procedure. An x-ray image is taken with a C-arm at a first pose, capturing a region of an endoscope with fiducials thereon. The C-arm is moved from the first pose to a second pose at another viewing angle while maintaining the position of the endoscope. Another x-ray image is taken with the C-arm at the second C-arm pose, capturing the region of the endoscope with the fiducials thereon. The location of the fiducials on each x-ray image is determined using segmentation. An iterative optimization is performed using the locations of the fiducials in the two x-ray images to form two-dimensional projections of the three dimensional curve of the region of the endoscope with fiducials thereon to determine the three-dimensional translation and rotation of the C-arm from the first x-ray pose to the second x-ray pose.

Abstract: An X-ray diagnostic apparatus includes a peak frequency detector detecting a peak frequency of a first harmonic in a moiré pattern of a grid in an image; a harmonic remover removing the first harmonic and a second harmonic in the moiré pattern from the image in accordance with the peak frequency of the first harmonic to obtain a first and second harmonic removed image; a harmonic extracting-filter generating unit calculating a peak frequency of a third harmonic in the moiré pattern in accordance with the peak frequency of the first harmonic to generate a harmonic extracting filter to extract the third harmonic; a harmonic extracting unit extracting the third harmonic from the first and second harmonic removed image based on the harmonic extracting filter; and a harmonic subtracting unit subtracting the extracted third harmonic from the first and second harmonic removed image to obtain a third harmonic removed image.

Abstract: There is provided a radiographic imaging device including: a radiographic imaging device main body; and a protective cover that is removably applied to a surface of the radiographic imaging device main body, a thickness including the radiographic imaging device main body in the state in which the protective cover is applied being at most 16 mm.

Abstract: A method for collecting multi-energy CT data is provided. A method of reconstruction from multi-energy CT scan is further provided, in which data collection is performed on the first-class object at voltage values of m sampling points of the first-class voltage varied periodically, to obtain n sets of multi-energy first-class scan data {yi}; and a data collection is performed on a double-cylinder correction phantom at the voltage values of m sampling points to obtain combination coefficients, and thus obtaining corresponding combination coefficients Cifirstand Cisecondcorresponding to the case that the first-class scan data is collected in the ith projection angle at the first-class voltage; and the image vectors Xfirst and Xsecond are obtained by calculating a minimum value of the difference between the first-class scan data {yi} and the combination projection data CifirstPi*Xfirst+CisecondPi*Xsecond.

Abstract: A method and system for physiological gating is disclosed. A method and system for detecting and predictably estimating regular cycles of physiological activity or movements is disclosed. Another disclosed aspect of the invention is directed to predictive actuation of gating system components. Yet another disclosed aspect of the invention is directed to physiological gating of radiation treatment based upon the phase of the physiological activity. Gating can be performed, either prospectively or retrospectively, to any type of procedure, including radiation therapy or imaging, or other types of medical devices and procedures such as PET, MRI, SPECT, and CT scans.

Abstract: A method and device for monitoring a fetal heart rate includes a reference fetal heart rate detected across an ultrasound depth zone of sensitivity. The ultrasound depth zone of sensitivity is scanned in overlapping increments of a first depth. An average fetal heart rate detected for each overlapping increment is tested for a coincidence with the reference fetal heart rate. Overlapping increments with the coincidence and a maximized signal quality rate are identified. An ultrasound depth increment of a second depth is selected representing the selected adjacent increments. Fetal heart rate is determined from an ultrasound signal returned from a scan depth of the second depth.

Abstract: Provided are methods and systems for detecting a maturing arterio-venous fistula comprising a vein. An exemplary method comprises determining a wall thickness of the fistula and a lumen diameter of the fistula vein using a high frequency ultrasound imaging system. A blood pressure of the subject is determined. A circumferential vessel wall stress is determined from the measured blood pressure, the wall thickness of the fistula and a determined radius of the measured diameter of the fistula. The determined circumferential vessel stress is compared to a predetermined threshold stress to determine if the fistula is mature.

Abstract: An ultrasound imaging device and method for clutter filtering is provided. The ultrasound imaging device provides logic for calculating signal characteristic values from an in-phase/quadrature-phase (I/Q) of an ultrasound signal reflected from an object and determining to remove a clutter element from the I/Q signal through comparison of the calculated signal characteristic values. Accordingly, the ultrasound imaging device provides a blood flow distribution of the object, more precisely visualized, to a user.

Abstract: There are provided embodiments for providing a motion mode image corresponding to a motion of a target object. In one embodiment, by way of non-limiting example, an ultrasound system comprises: a user input unit configured to receive input information for setting a region of interest on a brightness mode image; and a processing unit configured to form the brightness mode image based on first ultrasound data corresponding to a target object and form vector information of the target object based on second ultrasound data corresponding to the target object, the processing unit being further configured to form a motion mode image including at least one of a brightness motion mode image and a color motion mode image based on the first ultrasound data and the vector information corresponding to the region of interest.

Abstract: A low-loss high-voltage multiplexer is implemented using a transformer that is connected to one transmitter, one receiver and transducer elements. At least one primary winding is magnetically coupled at least two secondary windings. For example, a first transducer element and a second transducer element are connected to the secondary windings of a multiplexer that multiplexes between these transducer elements via the secondary windings. The multiplexer also optionally switches between the transmitter and the receiver during the transmission and the reception.

Abstract: Systems and methods for communicating ultrasound probe location and image information are provided. One system includes an ultrasound device coupled with an ultrasound probe and configured to acquire ultrasound images of a subject. The ultrasound imaging system also includes at least one camera configured to acquire (i) scene information including ultrasound imagery of the ultrasound probe with the subject during an image scan and (ii) ancillary probe data. The ultrasound imaging system further includes a processor configured to receive the ultrasound images and the ancillary probe data and a multiplexing unit configured to receive (i) the ultrasound images and ancillary probe data from the processor and (ii) the scene information from the camera, wherein the multiplexing unit is further configured to associate in time the ultrasound images, ancillary probe data and scene information. The ultrasound imaging system additionally includes a communication device.

Abstract: This disclosure may disclose, inter alia, a handle for actuating a device. The handle may include a top comprising a first end and a second end, a first top side coupled to the first end of the top via a first corner hinge, and a second top side coupled to the second end of the top via a second corner hinge. The handle may further include a first bottom side coupled to the first top side via a first side hinge, a second bottom side coupled to the second top side via a second side hinge, and a bottom coupled to the first bottom side via a third corner hinge and coupled to the second bottom side via a fourth corner hinge. In some examples, actuation of the handle may cause deployment or retraction of an element from or into a shaft.

Abstract: A retractor having an elongate portion with first and second parts each with adjacent pivotally connected segments pivotable from a first configuration to a second configuration, wherein in the second configurations the adjacent segments abut each other to inhibit further movement, at least one of the parts including a control whereby a force required to move the first part from the first configuration towards the second configuration is less than the force required to move the second part from the first configuration towards the second configuration, and an actuator arranged to urge the first and second parts from the first to the second configurations at the same time.

Abstract: A surgical tool well suited for less invasive surgery. Uses include spinal surgery and microdecompressive techniques. The method and device are useful for rearchitecting the spine. A cutting tip or head on a shaft is shielded during non-use to protect tissue and neural elements. To further protect neural elements and tissue, an inflatable retractor is introduced into the body with the surgical tool.

Abstract: A method for closing a fissure in a region of tissue having an inner surface and an outer surface, the method comprising: providing at least a pair of transverse anchor components, each transverse anchor component being coupled to at least one flexible longitudinal fixation component having a longitudinal axis; placing the transverse anchor components relative to the inner surface of the tissue on both sides of the fissure such that an exposed end of a flexible longitudinal fixation component extends through the tissue and past the outer surface of the tissue on both sides of the fissure; applying axial tension to the exposed ends; and anchoring the exposed ends.

Abstract: A flexible fixation assembly including a flexible main body and a suture engagement portion of the flexible main body. The suture engagement portion is configured to cooperate with a suture to mate the suture with the flexible main body. The flexible main body is configured to flex outward against walls of a bone hole when implanted therein to retain both the flexible main body and the suture mated therewith within the bone hole.

Abstract: A system for transdermal repair of soft tissue includes an instrument comprising a proximal actuator portion, a fixed needle having a lumen and extending distally from the proximal actuator portion, and a movable needle having a lumen and extending distally from the proximal actuator portion. The movable needle is movable axially between an advanced position and a retracted position relative to the proximal actuator portion. A suture needle is disposed within the lumen of one of the fixed and movable needles, and has a length of suture connected thereto. Needle graspers are disposed in the lumen of each needle, for securing the suture needle and assisting in the transfer of the suture needle from one needle to the other to complete a suture passing step.

Abstract: In various embodiments, a tissue thickness compensator can comprise a compressible extracellular matrix and a bioabsorbable material dispersed within the extracellular matrix, wherein the bioapsorption of the bioabsorbable material is configured to leave behind channels in the extracellular matrix. The tissue thickness compensator can also comprise generation means for generating the ingrowth of tissue into the channels. In at least one embodiment, the tissue thickness compensator can comprise dissolvable wicking members which, when dissolved, can leave behind channels in the tissue thickness compensator. In certain embodiments, the tissue thickness compensator can comprise at least one rupturable capsule.