Abstract: An exemplary method of treating obesity or dyslipidemia of a patient using a small implantable electroacupuncture device (IEAD) includes 1) implanting the IEAD below the skin surface of the patient at or near a target tissue location selected from the group of target tissue locations comprising acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, LR8 and their underlying nerves, the saphenous nerve and the peroneal nerve, and 2) enabling the IEAD to provide EA stimulation pulses in accordance with a stimulation regimen that provides a stimulation session having a duration of T3 minutes at a rate of once every T4 minutes, where the ratio of T3/T4 is no greater than 0.05, and wherein T3 is at least 10 minutes and no greater than 60 minutes.

Abstract: An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to at least one of a saphenous nerve and a peroneal nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of the saphenous nerve and the peroneal nerve by way of a central electrode and an annular electrode located on a housing of the electroacupuncture device.

Abstract: An exemplary method for treating obesity in a patient comprising the steps of 1) implanting a coin-sized electroacupuncture (EA) device in the patient below the patient's skin at at least one specified stimulation site, 2) enabling the EA device to generate stimulation sessions at a duty cycle that is less than 0.05, each stimulation session comprising a series of stimulation pulses, wherein the duty cycle is the ratio of T3/T4, where T3 is the duration in minutes of each stimulation session, and T4 is the time in minutes between stimulation sessions, and 3) delivering the stimulation pulses of each stimulation session to the at least one specified stimulation site through at least two electrodes/arrays attached to an outside surface of the EA device.

Abstract: A medical solution packaging assembly comprising a medical solution container that houses a medical solution comprising a semi-permeable material including one or more surface that is at least partially permeable to air molecules and has low permeability to vapor molecules of the medical solution, wherein the medical solution container is configured to inflate beyond its original volume. The assembly further comprising a packaging comprising one or more surface within which the solution container resides; a compressing mechanism configured to apply external force onto at least one surface of the medical solution container or limit the volume to which the medical solution container inflates, wherein a volume of air ingress from an external environment of the medical solution container is less than that which would occur without the compressing mechanism.

Abstract: The invention relates to a connector for containers containing medicinal active ingredient, which connector makes it possible to transfer active ingredient from one container into another container.

Abstract: A medication applicator for accurately and precisely dispensing medication is provided herein. The applicator can dispense any non-solid medication that does not require subcutaneous administration. Most topical and oral medications can be dispensed from the medication applicator. The medication applicator has a twist grip causes a predetermined dosage amount to be dispensed. When the twist grip is rotated, an internal plunger advances within the applicator causing medication to be dispensed from the applicator's tip. Some embodiments of the invention are one-use, disposable products. When not in use, a threaded cap screws onto the applicator's tip keeping it protected from accidental damage.

Abstract: A device for dispensing medication includes a cassette having a first circular wall defining a center opening, a second circular wall disposed about the first circular wall, and a plurality of removable dividers extending between the first circular wall and the second circular wall. The first circular wall, the second circular wall, and the plurality of removable dividers define a row of compartments. A device for dispensing mediation also includes a base unit capable of receiving the cassette, an electronic core extending vertically from the base unit and capable of extending through the center opening of the cassette, and a lid attached to the base unit.

Abstract: Dispenser and methods of dispensing substances is provided. The dispenser comprises a housing having a longitudinal axis, the housing configured to receive a packet comprising at least one collapsible cavity containing at least one substance, a support member positioned in the housing, the support member having a longitudinal axis essentially parallel to the longitudinal axis of the housing, a wedge coupled to the support member, the wedge configured to move in a plane substantially parallel within the longitudinal axis of the housing, the wedge receiving a force directed substantially normal to the longitudinal axis of the housing, and a reciprocating actuator coupled to the housing and engagable with the support member, the actuator moveable between a first position and a second position whereby the wedge advances a single predetermined increment collapsing a portion of the cavity.

Abstract: Systems and methods are provided for monitoring medication compliance to allow a doctor or medical care provider to determine whether a subject is ingesting a prescribed medication at the proper times. This can include the capability of remote access to remotely monitor compliance. A medication container includes a plurality of medication-containing cells, with frangible covers overlaying each cell. An electrical circuit includes a sequential value element associated with each cell, with the sequential value elements being connected in parallel and having a unique value. When the cover of a cell is broken, the associated sequential value element is uncoupled from the electrical circuit. A measurement device calculates the combined value of the sequential value elements coupled to the electrical circuit to determine which of the cells have been accessed via breakage of the associated cover.

Abstract: An electronic pill box having a housing with a base and grid and into which a blister pack is selectively engaged. The blister pack includes a plurality of vials prefilled with medication and sealed with a cover imprinted with pertinent information. Each vial is received in a chamber in the base having an LED and a sensor for determining whether medication has been removed therefrom. The LED and sensor are operatively engaged with a microprocessor including programming for dispensing medication from the pill box. An alert is issued if medication is not removed from an illuminated vial after a predetermined time interval. When all medication has been dispensed therefrom, the blister pack is replaced with another prefilled blister pack A card with patient information thereon may be provided on the prefilled blister pack and is detached and stored in the housing prior to loading the blister pack therein.

Abstract: A nipple with a developed pressure adjusting valve mounted in the bottom of air cavity of a mounting flange and shaped like a hollowed cylinder having a closed end, with the inside of the valve is used as a valve cavity for air flowing. A side wall of the valve above the bottom-closed end is formed with at least one slit at a part of periphery of the valve. Through the airflow passageway of the valve, the slit serves as an open-closed door to allow air to flow into the liquid-containing bottle advantageously, the air can flow into the liquid-containing bottle easily and conveniently, allowing the liquid to flow out from the bottle continuously and steadily, preventing the nipple from collapsing and preventing a vacuum formed inside the bottle as well as preventing the leakage of liquid from the valve when the bottle is inverted or sucked.

Abstract: A combined pacifier holder and stand whereby the pacifier is attached to a stand and held in an ‘at the ready’ position for an infant to retrieve and spit out on their own. The top of the stand attaches to a pacifier to hold it near the infant's mouth. The bottom of the stand connects to a base that separately fastens to an infant's clothing, blanket, toy, or other infant item. The stand is made of a sturdy, flexible material such that it can bend and twist as the infant moves its head from side to side.

Abstract: Provided is a dental filling and restorative material kit, including: a polymerizable composition (A) for a dentin restorative material for restoring a dentin portion; and a polymerizable composition (B) for an enamel restorative material to be layered on the dentin restorative material, in which the polymerizable composition (A) for a dentin restorative material and the polymerizable composition (B) for an enamel restorative material have different color tones, and in which a difference (nDa-nDb) between a refractive index nDa of a polymer of a polymerizable monomer (a) in the polymerizable composition (A) for a dentin restorative material and a refractive index nDb of a polymer of a polymerizable monomer (b) in the polymerizable composition (B) for an enamel restorative material is 0.005 or more.

Abstract: A palladium-dominated dental alloy, in particular a ceramic-bonding dental alloy for the manufacture of dental prostheses such as crowns, bridges, inlays, or onlays, containing at least gold, palladium, and silver, as well as a grain-growth inhibitor in the form of ruthenium. In order to achieve a fine-grained separation without the formation of agglomerates to obtain a dental alloy with high mechanical stability and excellent polishing characteristics, it is proposed that the dental alloy contain—in addition to ruthenium as grain-growth inhibitor—at least one element of the group tantalum, niobium, yttrium, zirconium, chromium, and molybdenum as grain-refinement control element.

Abstract: A curable dental composition comprising an addition-fragmentation agent and a curable dental resin is disclosed.

Abstract: A web material containing one or more active agents and methods for making same are provided.

Abstract: Cosmetic composition for making up and/or caring for keratin materials, in particular the skin and/or the lips, including: at least one aqueous phase gelled with at least one polymeric gelling agent that is natural or of natural origin; and at least one oily phase gelled with at least one lipophilic gelling agent chosen from particulate gelling agents, organopolysiloxane elastomers, semi-crystalline polymers and dextrin esters, and mixtures thereof; the phases forming therein a macroscopically homogeneous mixture.

Abstract: Microcapsules comprised of a core comprising one or more sunscreen agents and a shell of a wall-forming polymeric material, which are non-rupturable upon rubbing or pressing on the skin, and processes of preparing same are disclosed. Topical formulations comprising the microcapsules, which can be, for example, sunscreen formulations or skin care formulations, are also provided.

Abstract: The present invention provides an oral composition comprising: (a) from 1 wt % to 60 wt % of a calcium-containing abrasive; (b) a calcium-catching phosphate source in an amount sufficient to provide at least 100 mM of phosphate ions, PO43?; (c) no more than 20 wt % of a humectant; and (d) at least 5 wt % of water; wherein the oral composition has a pH from 8 to 11.

Abstract: A particulate metal oxide is provided that includes a cationic portion containing a zinc portion, a first manganese dopant portion and a second dopant portion selected from the group consisting of iron and aluminum, wherein the zinc portion is about 99% by weight or more of the cationic portion and the manganese dopant portion and second dopant portion are present in a weight ratio of from about 5:1 to 1:5.

Abstract: A particulate metal oxide includes a cationic portion that includes a zinc portion, a first iron dopant portion and a second dopant portion consisting of manganese and copper, where the zinc portion is about 99% by weight or more of the cationic portion, and the weight percent of the second dopant portion is greater than twice the weight percent of the first iron dopant portion.

Abstract: The application relates to a powdered composition consisting in at least one pigment, at least one encapsulation agent, at least one whitening agent, at least one lightening agent, optionally an additive selected from vitamin B3, vitamin E, a ginseng extract, a red algae extract, a brown algae extract and mixtures thereof and optionally water, to its preparation method and to its use for preparing a cosmetic composition.

Abstract: A hair treatment composition, particularly a hair colouring and/or bleaching composition, comprising one or more oxidizing agent(s), one or more alkalizing agent(s) selected from the group consisting of ammonia, its salts and mixtures thereof, one or more fatty alcohol(s), one or more non-ionic surfactant(s) and a low amount of specific fatty compound(s). It is also provided a kit and method thereof. Superior hair treatment performance, particularly superior colouring and bleaching performance, with a reduced or an eliminated smell of said alkalizing agent(s) upon application, is achieved.

Abstract: A method of straightening hair comprising the step of applying to the hair a composition comprising from 0.5 to 20 wt % of an unsaturated tricarboxylic acid having a carbon chain length from C2 to C8.

Abstract: Described herein are topical skin compositions useful for protecting the skin from the sun. The topical skin compositions comprise cosmetic ingredients such as homosalate; octisalate; oxybenzone; octocrylene; avobenzone; C12-15 alkyl benzoate; dicaprylyl carbonate; glycerin; VP/eicosene copolymer; cetearyl alcohol; caprylyl methicone; ceteth-20 phosphate; silica; and ammonium acryloyldimethyltaurate/VP copolymer. The compositions may also comprise other cosmetic ingredients, examples of which include film formers, preservatives, emulsifiers, conditioning agents, and moisturizers. Also disclosed are methods of using the topical skin compositions.

Abstract: Described herein are topical skin compositions useful for protecting the skin from the sun. The topical skin compositions comprise cosmetic ingredients such as homosalate, octisalate, oxybenzone, octocrylene, avobenzone, dimethicone, butylene glycol, styrene/acrylates copolymer, C12-15 alkyl benzoate, dicaprylyl carbonate, glycerin, ceteareth-25, dimethicone crosspolymer, magnesium aluminum silicate, acetyl dipeptide-1 cetyl ester, Crithmum maritimum extract, hydrolyzed algin, ascorbic acid, plankton extract, and Opuntia tuna fruit extract. The compositions may also comprise other cosmetic ingredients, examples of which include film formers, preservatives, emulsifiers, conditioning agents, and moisturizers. Also disclosed are methods of using the topical skin compositions.

Abstract: Described herein are compositions useful for protecting the skin from the sun. The compositions comprise cosmetic ingredients such as zinc oxide, titanium dioxide, butyloctyl salicylate, and a dermatologically acceptable vehicle. The compositions may further comprise additional ingredients such as cyclopentasiloxane, neopentyl glycol diheptanoate, butylene glycol, caprylyl methicone, PEG-9 polydimethylsiloxyethyl dimethicone, glycerin, polyglyceryl-6 polyricinoleate, lauric acid, aluminum hydroxide, potassium sorbate, and citric acid.

Abstract: A method for improving skin scar colour matching, for example reducing scar hyperpigmentation, the method comprising administering a therapeutically effective amount of an agent, which positively modulates ?2-adrenergic receptor conformation, or receptor activity, or activation thereof, to a subject in need thereof. The subject typically is in need of improving skin scar colour matching, for example reducing scar hyperpigmentation, because the subject has or is at risk of hyperpigmentation. The subject typically is selected as being at risk of hyperpigmentation on the basis of one or more of the following factors: • the subject has previously developed hyperpigmentation of a scar • the subject tans readily on exposure to sunshine or ultraviolet (UV) radiation, rather than burning • the subject has a non-Caucasian racial origin • the subject's skin colour (for example in an area that is not tanned) is considered to be darker than that typical of a naturally fair-haired Caucasian person.

Abstract: The present invention is directed to glycyrrhetinimidyl hydroxyproline alkyl ester compounds and their protected derivatives and cosmetically acceptable salts thereof, methods of making the compounds, cosmetic compositions containing at least one of the compounds and methods of using the same to promote collagen production in human skin. The compounds and cosmetic compositions of the invention provide various advantageous properties to the human skin.

Abstract: The invention is directed to a cosmetic composition and the precursor thereof. The composition has solid agent and liquid agent, both of which are cosmetic benefit ingredients. The solubility of solid agents in liquid agents in the inventive compositions is enhanced in the presence of a tricyclodecane amide.

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

Abstract: The present invention provides a hair straightening composition with improved ease of use, which leads to an enhanced smoothness of the straightened hair. The composition comprises at least one carboxylic acid of the formula (I) in combination with at least one quaternary ammonium compound having two long-chain hydrocarbon groups: R—CO—COOH Formula (I). In further aspects, the present invention concerns a process for semi-permanent straightening of the hair, utilizing said composition, the use of the composition for straightening hair, and a kit comprising the composition and a straightening iron.

Abstract: The present invention relates to the cosmetic use of queuine, in particular to combat ageing of the skin. It also relates to a cosmetic composition comprising queuine as active ingredient.

Abstract: The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the hue achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for colouring keratin-containing fibres, and to preparations or compositions for colouring keratin-containing fibres comprising these specific glucuronolactone derivatives.

Abstract: Provided herein is an oral care composition comprising an orally-acceptable aqueous vehicle and an antimicrobial ingredient, wherein the antimicrobial ingredient comprises a zinc ascorbylphosphate and methods for treating or preventing a disease or disorder of the oral cavity using the oral care compositions disclosed herein.

Abstract: The invention provides a non-aqueous oral care composition suitable for cleaning the surfaces of the oral cavity, the composition comprising: (a) from 20 to 90 wt % (by weight by based on the total weight of the composition) of one or more organic polyols having 3 or more hydroxyl groups in the molecule; (b) from 3 to 75 wt % (by weight based on the total weight of the oral care composition) of one or more particulate abrasive cleaning agents; (c) from 0.2 to 5 wt % (by weight based on the total weight of the oral care composition) of one or more surfactants, and (d) from 0.01 to 5 wt % (by weight based on the total weight of the oral care composition) of xanthan gum. The composition is easy to manufacture without the need for careful temperature control. It is also un expectedly stable and cost-effective, with suitable viscosity characteristics despite its non-aqueous nature.

Abstract: The invention relates to a photo-protective personal care composition that provides high sun protection factor (SPF). It has been found by way of the present invention that specific non-ionic surfactants interact synergistically with hollow microspheres in a cosmetic base comprising low amount of fatty acid to enhance the SPF of low organic sunscreen containing composition.

Abstract: Disclosed herein is an aqueous hair care composition capable of providing durable non-permanent hair styling and/or wash-resistant retention of shape of hair fibers comprising a polyelectrolyte complex having a gel matrix structure or a mixture of gel matrix and microgel formed by electrostatic attraction, wherein the polyelectrolyte complex comprises a complex between: (A) about 0.01 wt. % to about 20 wt. % of at least one anionic polymer containing monoacid, diacid, triacid, half-acid/half-ester, acid anhydride functionality, or salts thereof having a molecular weight of from about 100,000 Daltons to about 5000,000 Daltons; and (B) about 0.1 wt. % to about 20 wt. % of at least one cationic or pseudo cationic polymer having a (i) molecular weight range of about 80,000 Daltons to about 5,000,000 Daltons, and (ii) a charge density of less than about 4.0 meg/gram, and wherein, the charge ratio of (B):(A) is more than about 0.70.

Abstract: A cosmetic composition comprising a thickening polymer having hydrophobic and hydrophilic portions, a non-ionic surfactant, a neutralising agent, a non-ionic kosmotrope and water. Also, a hair colorant formulation obtained from mixing said composition and a hair dye. Also, the use of said formulation for colouring and/or sculpting hair.

Abstract: The present invention provides for a formulation comprising: at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid.

Abstract: The present invention relates to a method for producing a transparent or semi-transparent liquid glycerin derivative-modified silicone composition that comprises a hydration step of adding water to a liquid glycerin derivative-modified silicone or composition thereof. The present invention can provide a liquid glycerin derivative-modified silicone composition having a transparent or semi-transparent appearance can be provided.

Abstract: A skin and hair moisturizing composition. The skin and hair moisturizer composition includes coconut oil, petroleum jelly, apricot kernel oil, and vitamin E. The composition utilizes coconut oil and apricot kernel oil in order to provide an aromatic moisturizer. Additionally, the skin and hair moisturizing composition includes petroleum jelly to alleviate severely dry skin, wherein vitamin E is used to combat free-radicals resulting from exposure to the sun. The composition can be used all over an individual's body, obviating the need to buy multiple different moisturizers for different applications to the body, and helps individuals who have dry skin conditions, such as eczema. The composition can be utilized at home or can be offered for use in hair salons in order to moisturize hair.

Abstract: The invention provides a composition comprising reaction products from a reaction of a natural butter or natural oil such as shea butter with glycerin in the presence of a basic catalyst and wherein the reaction products retain the unsaponifiable portion of said natural butter or natural oil. The resulting reaction products are self-emulsfiable and are particularly useful in personal care, cosmetic, pharmaceutical, paper and textuile applications.

Abstract: Described herein are lipstick compositions that are substantive, aesthetically appealing, do not pool on the lips, are easy to spread, and moisturize the lips. The compositions comprise cosmetic ingredients such as conditioning agents, moisturizing agents, antioxidants, structuring agents, emulsifiers, silicone containing compounds, essential oils, thickening agents, preservatives, and colorants, for example.

Abstract: An improved hair color formulation treats hair to provide volume, viscosity, color and hair follicle stimulation. The color formulation is appointed to be used in hair products, and comprises a natural color agent and at least one agent providing anti-dihydrotestosterone (DHT) effects. Hair products include styling products, cleansing products, concealment products, and dying products. In one embodiment, the formulation comprises an aqueous emulsion, at least one hydrocarbon, at least one thickening agent, at least one humectant, at least one emollient, at least one fatty acid ester, and at least one agent providing anti-dihydrotestosterone (DHT) effects, such as caffeine, and at least one color agent. Preservatives, fibers and further treatments for male/female pattern baldness may also be added to the composition. Natural colorants are added to the hair color formulation to provide temporary coloring in addition to enhanced volume, viscosity and hair follicle stimulation.

Abstract: Methods of using extracts of Eurya groffii to impart benefits to skin and/or improve skin conditions resulting from aging or damaged skin.

Abstract: The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.

Abstract: A cosmetic composition is disclosed for applying to skin. The composition includes a liquid and dispersed in the liquid: any amount or form of fucoidan, any amount or form of beta glucan; and any amount of a marine extract. When the cosmetic composition is applied to the skin, the appearance of the skin is improved.

Abstract: Described herein are compositions that contract and reduce pore size. The compositions of the disclosure are also useful for collagen contraction of the skin, calming skin, and reducing oil on the skin. The compositions comprise cosmetic ingredients such as glycerin; cyclopentasiloxane; polysilicone-11; pentaerythrityl tetraethylhexanoate; dipropylene glycol; methyl methacrylate crosspolymer; betaine; bis-PEG/PPG-16/PPG-16/16 PEG/16 dimethicone; Albizia julibrissin bark extract; Evodia rutaecarpa fruit extract; hydrolyzed soy flour; sea whip extract; and a dermatologically acceptable vehicle.

Abstract: The invention relates to a cosmetic composition comprising at least one cosmetically acceptable excipient and from 0.01 to 1% by weight, preferably from 0.05 to 0.6%, and more preferably from 0.1 to 0.3% by weight of the combination of an extract of the brown alga Laminaria digitata, of a Saccharomyces hydrolysate and of ascorbic acid or one of its esters, the percentage being expressed by dry weight. The combination of active agents of the invention for which a synergistic effect with regard to the synthesis of the procollagen I has been shown also produces an advantageous effect with regard to other markers of aging.