Abstract: Provided is a glass composition suitable for a glass substrate for a flat panel display such as a liquid crystal display. This glass composition has high thermal stability, and is substantially free of BaO but has a low devitrification temperature. It is suitable for the production of a glass substrate by a downdraw process. This glass composition contains, in terms of mass %: 54 to 62% of SiO2; 4 to 11% of B2O3; 15 to 20% of Al2O3; 2 to 5% of MgO; 0 to 7% of CaO; 0 to 13.5% of SrO; 0 to 1% of K2O; 0 to 1% of SnO2; and 0 to 0.2% of Fe2O3, and is substantially free of BaO. In this glass composition, the total content of alkaline earth metal oxides (MgO+CaO +SrO) is 10 to 18.5 mass %. The devitrification temperature of the glass composition is 1200° C. or lower.

Abstract: Disclosed are sanitary wares such as toilet bowls or wash bowls that have a glaze layer which can conceal the body of the sanitary wares satisfactorily without the need to use any opacifier and which is less likely to be contaminated. The sanitary ware includes: a sanitary ware body; and a glaze layer having a single-layer structure as a sole glaze layer on the sanitary ware body, the glaze layer comprising a phase-separated glass as the major part and the glaze layer having a surface roughness Ra of not more than 0.07 ?m. Thus, the body of the sanitary ware can be concealed satisfactorily, and, in a preferred embodiment, a good white color can be imparted to the sanitary ware.

Abstract: Glass fibers having non-circular cross sections, excellent strength and excellent modulus of elasticity, and a fiber-reinforced resin compact using the same are provided. The glass fibers having non-circular cross sections are obtained by spinning the molten glass prepared by melting a glass composition as a raw material for the glass fibers. The glass fibers have a composition in which the content of SiO2 is 57.0 to 63.0% by mass, the content of Al2O3 is 19.0 to 23.0% by mass, the content of MgO is 10.0 to 15.0% by mass and the content of CaO is 5.5 to 11.0% by mass, in relation to the total amount of the glass fibers, and the ratio of the content of MgO to the content of CaO, MgO/CaO falls within a range from 0.8 to 2.0.

Abstract: A method of making an anti-reflective film comprises preparing a liquid composition with specific amounts of tetraethyl orthosilicate, polyethylene glycol, HCl, ethanol and at least one alcohol having a higher boiling point than ethanol and miscibility with both ethanol and water; applying the liquid composition onto a surface of a substrate to form a liquid film; evaporating the ethanol and the at least one alcohol from the liquid film to form a solid film; and heating the solid film to form a silica film.

Abstract: A window for a display device includes a display device window mother substrate; and a color layer on the display device window mother substrate. The color layer includes a transparent ink layer on the display device window mother substrate and including a pigment particulate, a solid color layer on the transparent ink layer, and a shield ink layer on the solid color layer.

Abstract: Absorbing layers of a low-emissivity (low-E) coating are designed to cause the coating to have a reduced film side reflectance which is advantageous for aesthetic purposes. In certain embodiments, the absorbing layers are metallic or substantially metallic (e.g., NiCr or NiCrNx) and are positioned in order to reduce or prevent oxidation of the absorbing layers during optional heat treatment (e.g., thermal tempering, heat bending, and/or heat strengthening). Coated articles according to certain example embodiments of this invention may be used in the context of insulating glass (IG) window units, other types of windows, etc.

Abstract: The present invention, in one aspect, provides aqueous dispersions of carbon nanotubes. In some embodiments such aqueous dispersions can be applied to fiber glass strands to impart one or more electrically conductive properties to the fiber glass strands.

Abstract: We herewith propose the use of at least one nitrogen-containing organic compound and/or a salt thereof in combination with at least one aromatic carboxylic acid and/or a salt thereof for improving the freeze-thaw stability of an alkali-activated aluminosilicate binder, and a preferred alkali-activated aluminosilicate binder comprising ?-caprolactam and sodium benzoate as freeze-thaw stabilizers.

Abstract: The present invention relates to a new formaldehyde-free binder composition for mineral wool products, wherein the binder composition is an aqueous composition containing starch, wherein an amount of 95 weight % or more of the starch is water-insoluble native starch, and an acrylic component. The present invention also relates to the use of this formaldehyde-free binder composition in the manufacturing of mineral wool insulation products. Finally, the present invention relates to a process for manufacturing the formaldehyde-free binder composition wherein a dispersion of starch, wherein an amount of 95 weight % or more of the starch is water-insoluble native starch, is brought in contact with the acrylic component at a temperature of not higher than 40° C.

Abstract: Preparing porous materials includes forming a mixture including a geopolymer resin and a liquid between which a nanoscale (1-1000 nm), microscale (1-1000 m), and/or milliscale (1-10 mm) phase separation occurs. The mixture is solidified (e.g., at an ambient temperature or a relatively low temperature), and a portion (e.g., a majority or a significant majority) of the liquid is removed from the solidified mixture. The liquid can include organic liquids from agricultural, geological, industrial, or household sources. The porous materials have accessible pores with a range of pore sizes including nanoscale pore sizes, microscale pore sizes, milliscale pore sizes, or a combination thereof. The porous material may be treated further to form another material, such as a composite.

Abstract: Disclosed is a refined white ceramic material, which belongs to the field of ceramic materials for component packaging, and comprises the following raw materials by weight in percentage: aluminum oxide 87-93, magnesium oxide 0.8-5, silicon dioxide 1-6, calcium oxide 0.6-4, titanium dioxide 0.01-0.5, and zirconium dioxide 0.5-3. The method for preparing same comprises: (1) washing aluminum oxide grinding balls and a ball-milling tank, and drying for later use; (2) weighing a solvent NP-10 of 0.5-4 by weight in percentage, and adding the solvent into the ball-milling tank; (3) weighing raw materials, adding the raw materials into the ball-milling tank, and performing ball milling for 72±0.5 h. By means of the refined white ceramic material of the present invention, the obtained ceramic grains have even sizes, small surface roughness, and high fracture resistance performance of ceramic body.

Abstract: A nonlinear resistor ceramic composition includes zinc oxide as main component, and, as subcomponents, with respect to 100 mol of zinc oxide in terms of respective elements, more than 0.05 to less than 30 at. % of oxide of Co, more than 0.05 to less than 20 at. % of oxide of Sr, more than 0.01 to less than 20 at. % of oxides of rare earth except for Sc and Pm, more than 0.01 to less than 10 at. % of oxide of Si and does not include Al, Ga and In. Alternatively, a nonlinear resistor ceramic composition includes zinc oxide as main component, and, as subcomponents, with respect to 100 mol of zinc oxide in terms of respective elements, more than 0.05 at. % and less than 30 at. % of an oxide of Co, more than 0.05 to less than 20 at. % of oxide of Sr, more than 0.01 to less than 20 at. % of oxides of rare earth except for Sc and Pm, more than 0.01 to less than 10 at. % of oxide of Si and more than 0.01 to less than 10 at. % of calcium zirconate in terms of CaZrO3.

Abstract: To provide a high zirconia fused cast refractory having high durability, which hardly has cracks at the time of production of the refractory, during the heating, by temperature changes during use and during the cooling at the time of suspension of operation. A high zirconia fused cast refractory which has a chemical composition comprising from 88 to 96.5 mass % of ZrO2, from 2.5 to 9.0 mass % of SiO2, from 0.4 to 1.5 mass % of Al2O3, from 0.07 to 0.26 mass % of Na2O, from 0.3 to 1.3 mass % of K2O, from 0 to 0.3 mass % by outer percentage of Li2O, at most 0.08 mass % by outer percentage of B2O3, and at most 0.08 mass % by outer percentage of P2O5, and contains B2O3+P2O5 in a content of at most 0.1 mass % by outer percentage.

Abstract: The invention relates to aqueous preparations of polymer-modified setting accelerators, said preparations being characterized in that at least one setting accelerator and at least one cationically stabilized polymer are contained therein.

Abstract: An insensitive melt-cast explosive composition incorporating on the one hand a meltable part formed of at least one meltable explosive and, on the other hand, a solid part incorporating oxynitrotriazole (ONTA) and cyclonite (RDX). This composition is characterised in that the cyclonite is a cyclonite of reduced sensitivity, the particle size of the insensitive cyclonite being of between 315 micrometers and 800 micrometers, whereas the particle size of the ONTA is of between 200 micrometers and 400 micrometers, the ONTA further having an apparent density greater than or equal to 0.95 g/cm3. The invention is applied to the loading of projectiles by casting.

Abstract: A biomass gasification gas purification system has a dust removal apparatus for filtering soot and dust from biomass gasification gas (including tar component) obtained through the gasification of the biomass using a biomass gasification furnace, a desulfurization apparatus for removing sulfur oxide component in the filtered biomass gasification gas, first to third pre-reformation reactors that provide pre-reforming catalyst for reforming the tar component in the biomass gasification gas after desulfurization, and first and second coolers that are interposed between the first to third pre-reformation reactors, and for cooling the reformed gas.

Abstract: A process for the production of C4 olefins, which may include: contacting a hydrocarbon mixture comprising alpha-pentenes with an isomerization catalyst to form an isomerization product comprising beta-pentenes; contacting ethylene and the beta-pentenes with a first metathesis catalyst to form a first metathesis product comprising butenes and propylene, as well as any unreacted ethylene and C5 olefins; and fractionating the first metathesis product to for an ethylene fraction, a propylene fraction, a butene fraction, and a C5 fraction.

Abstract: A first method for refining dicyclopentadiene of the present invention is characterized in that the method separates and recovers dicyclopentadiene by distilling the crude dicyclopentadiene that contains dicyclopentadiene and is obtained by removing a C5 fraction and a BTX fraction from the reaction product obtained by dimerization reaction of the cracked gasoline by-produced in an ethylene plant that uses as feed stock a C2 fraction, a C3 fraction and a C4 fraction. A second method for refining dicyclopentadiene of the present invention is characterized in that the dicyclopentadiene-containing fraction refined by distillation is brought into contact with an inert gas or a hydrocarbon gas having 1 to 3 carbon atoms.

Abstract: The invention relates to a process to produce HCFC-244bb from HCFO-1233xf wherein, in one embodiment, co-feed species HFC-245cb is added to the reaction at a pressure of at least about 100 psig; and in another embodiment it is added to maintain a mole ratio of HFC-245cb to HCFO-1233xf of between about 0.005:1 to about 1:1. The HFC-245cb may be added as recycled by-product of the reaction and/or added as fresh feed. The HFC-245cb provides elevated pressures to the reaction thereby facilitating reactor operation, mixing and HCFC-244bb product removal. Other co-feed species are also disclosed.

Abstract: An object of the present invention is to provide a method that enables the easy and efficient (high yield, high selectivity, low cost) preparation of a fluorine-containing olefin substituted with an organic group or groups from a fluorine-containing olefin. [Solution] The method for preparing a fluorine-containing olefin substituted with an organic group or groups, the method comprising a step of reacting a fluorine-containing olefin with an organic boron compound in the presence of an organic transition metal catalyst containing at least one transition metal selected from the group consisting of nickel, palladium, platinum, rhodium, ruthenium, and cobalt.

Abstract: Maintaining long residence times during hydrothermal digestion of cellulosic biomass solids may be complicated by a number of factors, including biomass compaction. Advantages in this regard may be realized by digesting cellulosic biomass solids in an inclined digestion unit. Such methods can comprise: introducing cellulosic biomass solids to a hydrothermal digestion unit comprising one or more inclined surfaces therein; introducing a fluid phase digestion medium containing a slurry catalyst to the hydrothermal digestion unit, the slurry catalyst being capable of activating molecular hydrogen; supplying an upwardly directed flow of molecular hydrogen from a source disposed along each inclined surface as the cellulosic biomass solids descend along each inclined surface; and heating the cellulosic biomass solids as they descend along each inclined surface in the presence of the slurry catalyst and the molecular hydrogen, thereby forming an alcoholic component derived from the cellulosic biomass solids.

Abstract: Biomass compaction during hydrothermal digestion of cellulosic biomass solids may become problematic, particularly as the vertical height of a cellulosic biomass charge increases. Compaction may be decreased in a horizontally configured hydrothermal digestion unit.

Abstract: Process for the purification of an alcohol in the course of a process comprising: (1) providing a reaction zone (C) comprising an acid type catalyst; (2) providing a reaction zone (B) comprising an acid adsorbent material; (3) providing an alcohol stream comprising impurities; (4) introducing the alcohol stream of (3) into the reaction zone (B) and bringing said stream into contact with the acid adsorbent material at conditions effective to reduce the amount of impurities having an adverse effect on the acid type catalyst of the reaction zone (C); (5) recovering from step (4) an alcohol stream and introducing it into the reaction zone (C); (6) optionally introducing one or more reactants (R) into the reaction zone (C); (7) operating said reaction zone (C) at conditions effective to recover a valuable effluent.

Abstract: Embodiments of the present invention provide for production and recovery of ethanol or other volatile organic compounds, such as acetic acid, from solid biomass material. One embodiment comprises introducing a biomass material to a compartment of a solventless recovery system, wherein the biomass material contains one or more volatile organic compounds; contacting the biomass material with a superheated vapor stream in the compartment to vaporize at least a portion of an initial liquid content in the biomass material, said superheated vapor stream comprising at least one volatile organic compound; separating a vapor component and a solid component from the heated biomass material, said vapor component comprising at least one volatile organic compound; and retaining at least a portion of the vapor component for use as part of the superheated vapor stream.

Abstract: The invention relates to a process wherein a stream comprising dichlorohydrin, water, and HCI is separated into a stream which is rich in dichlorohydrin and low in HCI and an aqueous HCI stream which is low in dichlorohydrin. The process involves the distillation of the mixture comprising dichlorohydrin, water, and HCI with an amount of water being added before and/or during the distillation such that the water concentration during the distillation is on the line D-E, or to the right thereof, in the phase diagram of FIG. 1.

Abstract: The present invention relates to different forms of a HCV inhibitory compound.

Abstract: Described herein is a process for producing phenol in which (a) benzene and hydrogen are contacted with a hydroalkylation catalyst under hydroalkylation conditions to produce cyclohexylbenzene; (b) the cyclohexylbenzene is contacted with an oxidation catalyst under oxidation conditions to produce cyclohexylbenzene hydroperoxide; (c) the cyclohexylbenzene hydroperoxide is contacted with a cleavage catalyst under cleavage conditions to produce a cleavage effluent comprising phenol and cyclohexanone; (d) the cyclohexanone is contacted with a dehydrogenation catalyst under dehydrogenation conditions to produce a dehydrogenation effluent having at least a portion of the cyclohexanone and a first contaminant; and (e) the first contaminant is contacted with an acidic material under contaminant treatment conditions to convert at least a portion of the first contaminant into a converted first contaminant. Phenol compositions made from the above-described process are also described herein.

Abstract: A process to prepare an olefin from its corresponding alcohol is improved by reacting, under reaction conditions including a first temperature, an aliphatic alcohol and, optionally, diluent water, to form a reaction product including at least a dialkyl ether. The product is then reacted again, under higher temperature to complete the dehydration of the dialkyl ether to the desired olefin. This process is particularly suitable to prepare ethene from ethyl alcohol. The stepped temperature scheme serves to reduce the formation of byproduct aldehydes, which in turn reduces coke formation, fouling, and the need to handle large amounts of water, thereby lowering energy and capital costs.

Abstract: An integrated process for the production of acetic acid by carbonylating dimethyl ether with synthesis gas to form methyl acetate and unreacted synthesis gas, utilizing the unreacted synthesis gas to produce methanol, dehydrating and hydrolyzing a mixture of methyl acetate and methanol to produce acetic acid and dimethyl ether and recovering acetic acid therefrom.

Abstract: A process for allowing an oxidation reaction efficiently to produce an object aromatic carboxylic acid with an efficient productivity by improving a catalyst activity even in the presence of a relatively small amount of a catalyst is provided. The process comprises oxygen-oxidizing an aromatic compound having an alkyl group and/or an alkylene group as a substrate in the presence of a catalyst containing a cyclic imino unit having an N—OR group (wherein R represents a hydrogen atom or a protecting group for a hydroxyl group) and a transition metal co-catalyst (a cobalt compound, a manganese compound, and a zirconium compound) to produce the aromatic carboxylic acid corresponding to the aromatic compound. The oxidation reaction is carried out with feeding a mixture of the catalyst and at least one member selected from the group consisting of the substrate, a reaction intermediate (e.g., a ketone and an aldehyde), and a reaction product (e.g.

Abstract: A method for producing a high-quality barium titanyl salt includes using, as the fluids to be treated, at least two kinds of fluids, namely, a barium titanium mixed solution that is obtained by dissolving both a barium compound and a titanium compound in a solvent, a compound solution that is obtained by dissolving, in a solvent, a compound capable of deposing the barium and titanium contained in the barium-titanium mixed solution into a barium titanyl salt, and if necessary, one or more other fluids; and mixing these fluids together in a thin film fluid formed at least between two treating surfaces and to form a barium titanyl salt. The treating surfaces are so arranged as to face each other in an approachable/separable state with one of the treating surfaces and being capable of turning relatively to the other.

Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, and their use in the treatment and/or prevention of diseases and disorders.

Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent, ensuring that the reaction efficiently goes to completion.

Abstract: The ?,?-unsaturated ?-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.

Abstract: The invention relates to improved processes for the preparation of lacosamide. The invention also relates to a novel intermediate useful in the preparation of lacosamide. The invention also relates to process for the purification of lacosamide.

Abstract: The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.

Abstract: A compound represented by the following General Formula (I): where, in General Formula (I), R1 and R2 each represent an alkyl group which may have a substituent, R3 represents the following General Formula (II) or (III), and R1 and R2 may be identical or different, where, in General Formulas (II) and (III), X represents a hydrogen atom or a halogen atom, R4 represents a methyl group, a dimethyl group or an oxygen atom, and * represents a binding position.

Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.

Abstract: A surfactant represented by the formula: wherein: R1 is CH3(CH2)m and may be interrupted with at least one heteroatom selected from the group consisting of amine, ether, ester, amide, sulfur, sulfur monoxide, sulfer dioxide, sulfamate, hydroxy, or mixtures thereof; and m=6-16 n=0 or 1 R2=H or CH3; and R3=H, SO3X, CO(CH)2COOH, or COCH(SO3X)CH2COOX1; wherein X and X1 are the same or different, and each is selected from NH4+, an alkali metal, or an H atom.

Abstract: A method for producing a high purity, high quality amide compound, particularly a lactam. An amount of each of a halide, an aldehyde compound, an alcohol compound and a nitrile compound contained in a solution recycled into an oxime-forming step is controlled to an amount of 0.4 mol % or less based on the ketone as a starting material. One or more of a ketone, an oxime and an amide compound are purified by hydrogenation and/or crystallization for eliminating impurities containing a double bond. A content of impurities having a cyclic bridge structure is controlled using a cycloalkanone purified by recrystallization.

Abstract: Methods and materials for producing meso-biliverdin are provided where the methods include reacting phycocyanobilin with an amphoteric compound in a solvent to yield meso-biliverdin.

Abstract: The present invention relates to heterocyclic compounds which are positive modulators of metabotropic glutamate receptor. The present invention also relates to the use of these compounds for preparing a pharmaceutical composition and to a method of treating a medical disorder, selected from neurological and psychiatric disorders associated with glutamate dysfunction.

Abstract: The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above ?65° C.

Abstract: The present invention is directed to (?)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+)tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain.

Abstract: Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form.

Abstract: The present invention relates to disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted pyridine derivatives as inhibitors for a protein kinase.

Abstract: Disclosed are a glycine reuptake inhibitor and the use thereof. The glycine reuptake inhibitor is a compound of formula I, or isomers, pharmaceutically acceptable salts or solvates thereof, wherein R1 is one or more groups selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy; R2 is selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and C1-6 haloalkoxy; and each of R3 and R4 is independently selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy.

Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants, upper respiratory infections, (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis, neuropathic pain and pain associated with fibromyalgia.

Abstract: Disclosed are compounds of Formula (I): wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CF3, or —CH2CH2CH2CF3; R3 is —CH2CF3, —CH2CN, —CH2(cyclopropyl), pyridinyl, chloropyridinyl, or tetrahydropyranyl; Ring A is phenyl or pyridinyl; Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

Abstract: Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R1 is CH2CH2CF3; R2 is CH2(cyclopropyl), CH(CH3)(cyclopropyl), or CH2CH2CH3; R3 is H, CH3, or Rx; R4 is H or Ry; and Rx, Ry, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. The compounds of Formula (I) also include prodrugs of the Notch inhibitor compounds.