Abstract: A method for gas analysis can include continuously diverting a portion of drilling fluid into a sample chamber from a drilling fluid stream, creating a bidirectional drilling fluid circulation to liberate gas from the drilling fluid, applying a suction to a gas capturing chamber, and allowing a sample of the liberated fluid to continuously flow through the gas capturing chamber, continuously be filtered, and continuously flow into a gas analyzer. The method can include maintaining the sample chamber in an open configuration or decompressing the gas capturing chamber by closing off one or more sample inlets and sample outlets and exhausting portions of the liberated fluid that do not flow to the gas analyzer. The method can include simultaneously providing analysis data to client devices.

Abstract: The present invention aims to provide a gas sensor that can favorably be assembled by proper positioning of a connection terminal relative to a separator and a subassembly unit for such a gas sensor. In an oxygen sensor, a separator has protruding portions formed on a surface of a front end part thereof; an outer connection terminal has an outer fitting portion fixed to outer circumferential surfaces of the protruding portions under its biasing force; and an inner connection terminal has an inner fitting portion fixed to inner circumferential surfaces of the protruding portions under its biasing force. Thus, it is less likely that the outer and inner connection terminals will be displaced in position relative to the separator and is possible to allow proper positioning of the outer and inner connection terminals.

Abstract: A system for measuring nutritional parameters of food items is provided. The system includes a holding cavity. The system further includes a sensor assembly that includes a transmitter antenna and at least one receiver antenna. The transmitter antenna is configured to transmit signals to a food item in the holding cavity. The receiver antenna is configured to receive response signals from the food item. The system includes at least one switch coupled to each antenna. The switch, in a first state, is configured to set the sensor assembly to an electric potential equal to that of the holding cavity. In a second state, the switch is configured to couple the sensor assembly to a power source. The system also includes a processing unit to process the signals received to determine the nutritional parameters of the food item.

Abstract: Methods and systems for testing fluid samples include a diffused air flotation (DAF) system and a jar. The jar includes a diffuser for injecting the diffused air into the jar and a tap for drawing a fluid out of the jar.

Abstract: A process for a pre-concentration unit including: a sorbent material coated passage-way having an entrance for receiving a hydrocarbon-containing groundwater sample and for pre-concentrating the hydrocarbons in a hydrocarbon-containing groundwater sample by successive sorption/desorption cycles, and having an exit for discharging the pre-concentrated hydrocarbons; a heating unit for heating the sorbent material coated passage-way; and; an array of shear horizontal-surface acoustic wave sensors with coatings adapted for detecting and quantifying the pre-concentrated hydrocarbons, disposed at the exit of the sorbent material coated passage-way; and a housing for enclosing the pre-concentration unit and the array of shear horizontal-surface acoustic wave sensors, adapted for continuous use at a body of hydrocarbon-containing groundwater, and coupled to mathematical methods for generating concentrations of specific analytes from both transient and steady-state signals.

Abstract: A method for monitoring global crude oil quality. The method includes the steps of obtaining samples of a crude oil having a quality, generating characterization data from measurements of samples of the crude oil, determining values of properties of an assay of the crude oil using the data of step a), storing the values of the properties of the assay in a database, determining deviations of the values of the properties of the assay from the values of the properties of a recommended assay having a quality, determining a statistical significance of the deviations of the values of the properties of the assay from the values of the properties of the recommended assay to determine if the crude oil quality is different from the quality of the recommended assay, and determining if the statistical significance indicates a change in the economic valuation between the assay and the recommended assay.

Abstract: An apparatus for monitoring aeration in a fluid of a hydraulic circuit is provided. The apparatus includes at least two measuring units configured to connect at a first location, and a second location of the hydraulic circuit. The measuring units are configured to measure pressure, temperature, and density of the fluid at the respective locations. The apparatus further includes a computing unit configured to output aeration values of the fluid at the first and the second location based on the measured pressure, temperature, and density by the two measuring units. The apparatus further includes a correlation unit configured to correlate aeration levels at the first and second locations based on the measured aeration values.

Abstract: Systems and methods for automatically evaluating the useful life of an engine oil based on data corresponding to a plurality of preselected key oil properties. The evaluation includes determining, in connection with each of the pre-selected key oil properties, a first current measured oil property value, a first reference oil property value, a first deterioration-limit value, and a first weighting factor. The evaluation also includes determining a single index value, indicating a state of deterioration of the engine oil, in a calculation using each of the values and factors.

Abstract: The present invention includes: a main body which defines a storage space in the lengthwise direction, and in which a plurality of biosensors can be stacked; a cover member covering one end of the storage space and including a discharge hole through which only one biosensor located at the outermost edge of the stacked biosensors can pass; and a cover coupled to the cover member in order to be raised and lowered so as to open and close the discharge hole. The discharge hole is closed such that the biosensors stacked in the storage space are not contaminated and the infiltration of impurities into the storage space is prevented, and the discharge hole is temporarily opened when the biosensors are to be used in order to withdraw the biosensors.

Abstract: The present invention discloses an integrated sampling and dispensing device comprising a flexible container, a dropper with a sampling rod and a sample removing vessel disposed therebetween. The device of the present invention can be conveniently used for collecting specimen and dispensing the same after a reaction in a single device by simple manipulation of severing the sampling rod and turning the container upside down. Also by using the present device a constant amount of specimen can be used for each reaction which leads to a reliable and reproducible result.

Abstract: The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. Additional embodiments are described herein.

Abstract: The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors.

Abstract: Cytotoxic anti-LAG-3 monoclonal antibodies or fragments thereof causing depletion of LAG-3+ activated T cells are described, as are related pharmaceuticals and methods of treating. Also described are related nucleic acid and protein sequences.

Abstract: Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.

Abstract: Described are compositions and methods for detecting or monitoring the ability of an individual to mount a cell mediated immune response to a target antigen. Methods rely in part upon the physical association, e.g., by fusion, of a Lethal Factor (LF) polypeptide with a target antigen. The LF polypeptide moiety, including, for example, an LFn polypeptide moiety, serves as a transport factor to deliver target antigens, including full length target polypeptides, to the cytosol of an intact, living immune cell from an individual. Measurement of a cytokine response by the immune cell from the individual provides a read out of a cell mediated immune response. The methods and compositions described provide diagnostic as well as prognostic information and can guide the direction of therapy.

Abstract: The disclosure describes immunoassay methods for measurements of concentrations of related analytes in samples of body fluids from different mammalian species. More particularly, the disclosure describes reagents and methods that may be used for assays of a mammalian antigen across a range of different mammalian species, using immunological reagents based on non-mammalian antibodies the mammalian antigen. In addition, a calibrator or a set of calibrators are described that are assigned with concentration values for the antigen for each of the different mammalian species.

Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.

Abstract: Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.

Abstract: The present application provides a system (1) that comprises a mobile phone (25) to allow testing of samples from a patient at the point of care or environmental/industrial process monitoring tests to be performed in the field. The system (1) may be easily adapted for use with a variety of different mobile phones (25). The mobile phone (25) comprises an integrated camera (15). The system (1) further comprises an optical module (20) for receiving a sample for testing. The mobile phone (25) is configured to extract the intensity and/or color information from the camera (15).

Abstract: A biosensor includes a flexible foil with an electrode layer positioned on the foil. An adhesive layer is positioned on the foil layer, and a first photo-definable hydrogel membrane is positioned over the electrode layer and the adhesive layer. A second photo-definable hydrogel membrane with an immobilized bio-recognition element is positioned over the first hydrogel membrane in contact with the electrode layer through an opening in the first hydrogel membrane.

Abstract: A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and the result can be displayed.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genetic packages such as bacteria and bacteriophages enable high through-put identification of ligand binding molecules.

Abstract: The invention provides a method of analyzing interactions between pairs of target and effector cells utilizing high-throughput screenings methods for profiling large numbers of single cells in microarrays.

Abstract: An anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2): P-X1-X2-P-G-E??(1) (SEQ ID NO: 2) X3-X4-X5-F-Y-X6-L-X7-P-X8??(2) (SEQ ID NO: 3) (wherein, X1 represents L, V, N, T, S, M, or R; X2 represents F, Y, or M; X3 represents V or G; X4 represents N or S; X5 represents Q, P, or S; X6 represents S, T, or I; X7 represents A or S; and X8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.

Abstract: The present invention relates to method of detecting activity of a sample. Some methods involve detecting a neo-binding-site created by the activity such as detecting an activity of a protease by detecting a neo-binding-site created by cleavage of a substrate by the protease.

Abstract: Several embodiments provided herein relate to methods of diagnosing asbestos exposure or mesothelioma. Several embodiments also relate to methods of differentiating whether a tumor of the lung is lung cancer or mesothelioma.

Abstract: The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor, is also expressed in various cancers, including ovarian cancer and uterine cancer. Six SAS1R variants have been previously identified, and they are encompassed by the invention. The present invention further provides antibodies useful for targeting SAS1R expressing cells and for killing such cells.

Abstract: The present invention provides a fluorescent label that can be used for carrying out a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The fluorescent label is a fluorescent dye-containing nanoparticle in which the parent material is a cross-linked polymer and the fluorescent dye is an aromatic ring-based dye molecule. The cross-linked polymer is suitably a melamine resin or a styrene resin. The aromatic ring-based dye molecule is suitably a perylene and more suitably a perylene diimide.

Abstract: A method and a system for determining insulin sensitivity (IS) is described. In one aspect the method and the system can be implemented by receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue; applying a first kinetic model to obtain a plasma insulin concentration based on the first parameter; receiving a second parameter corresponding to a plasma glucose concentration; determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter.

Abstract: Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.

Abstract: [Problem] The present invention provides a novel pathological marker of angiitis which serves as an alternative to MPO-ANCAs. [Means for Solution] According to one embodiment of the present invention, a method for testing angiitis which includes a step of detecting an antibody specifically recognizing a moesin in a biological sample is provided. In addition, according to another embodiment of the present invention, a reagent for testing angiitis which contains a substance that detects an antibody specifically recognizing a moesin in a biological sample is provided.

Abstract: The invention provides a method for multiple cytokine detection from single cells for the purpose of generating immunological profiles of diseases.

Abstract: This invention relates to improved electrophysiological assays that measure sodium conductance activity of a delta or alpha human epithelial sodium channel (ENaC) expressed in a test cell in the presence and absence of delta hENaC enhancers. The improvement comprises contacting the test cells with an amount of sodium ion, typically from at least 15 mM to 140 mM, for a time sufficient, e.g. for at least 5 minutes to an hour, prior to the test cells being screened against at least one putative enhancer. It has been surprisingly discovered that this sodium pretreatment enhances assay sensitivity, especially assays that use membrane potential or ion sensitive dyes that detect changes in conductance fluorimetrically. These enhancer compounds have potential application in modulating (enhancing) salty taste perception and for treating disorders involving aberrant hENaC function.

Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.

Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.

Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally are directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.

Abstract: Devices contain dried reagents that may be reconstituted and used in the calibration and quality control of sensors. Methods of producing and using the devices are also disclosed.

Abstract: A sample analyzing system comprising: a first sample analyzer including a first measurement unit for measuring a sample and a first control unit for controlling the first measurement unit; and a second sample analyzer including a second measurement unit for measuring the sample and a second control unit for controlling the second measurement unit; wherein the first control unit is configured to transmit an activation signal for activating the second sample analyzer when a predetermined condition is met for the first sample analyzer; and the second control unit is configured to activate the second sample analyzer when the activation signal is received.

Abstract: The invention provides for a method of pipetting samples using a pipetting device including more than one pipetting unit. Each of the pipetting units are independently movable in Y and Z directions and includes an upper and a lower frame. Two adjacent pipetting units include a module arranged in a staggered manner in either of the respective upper and lower frames.

Abstract: Stepped portions of a flow channel are reduced by completely fixing the channel that extends to the measuring unit, and reducing connections in the channel, thereby to suppress a disturbance in the flow of the liquid suctioned into the measuring unit. A means is provided so that the reaction solution and reagent suctioned will move towards the channel through which the liquids are suctioned.

Abstract: A rotation detecting unit is adapted for a rotatable body. The rotation detecting unit includes a rotation detecting part, a signal transmission member, and a main body part. The rotation detecting part detects a rotational state of the rotatable body and outputs a rotation detection signal. The signal transmission member is electrically connected to the rotation detecting part to transmit the rotation detection signal to an external device. The main body part holds at least a part of the signal transmission member and the rotation detecting part. The main body part is integrally molded from thermosetting resin including a joined part obtained as a result of joining together a terminal of the rotation detecting part and the signal transmission member, the part of the signal transmission member, and the rotation detecting part. The main body part includes a recess at a region corresponding to the rotation detecting part.

Abstract: A robust and compact speed sensor assembly that includes a Hall effect sensor with protective circuitry in a compact housing that can be attached to the wheel of a motorcycle in the vicinity of the brake rotor to present the sensor Hall plate in a proper transverse-to-target orientation to detect passing targets, such as the brake rotor mounting bolts or magnets.

Abstract: Impact at a protective headpiece, for example a protective headpiece, may be characterized in part using an impact sensor including at least one acceleration sensor positioned on the protective headpiece. A microcontroller may be configured to identify and store acceleration sensor data based on the output values of the at least one acceleration sensor. A processor device receives the acceleration and/or deceleration data, and may determine whether the experienced impact force is associated with an impact force magnitude that is within a predetermined head injury range of magnitude. An impact alert may be generated when the impact force magnitude is within the predetermined head injury range of magnitude, wherein a predetermined head injury range of magnitude may be adjustable between a practice setting and a game setting, and wherein the impact alert may be visible to an individual wearing the protective headpiece. An electronic device (e.g.

Abstract: A physical quantity sensor includes a substrate, an oscillating member that is disposed over the substrate, support portions that support the oscillating member and that are disposed along a first axis, and detection electrodes that are disposed on the substrate so as to oppose the oscillating member. The oscillating member has a pair of side faces intersecting a second axis perpendicular to the first axis in a plane, and a protrusion is formed on at least one of the pair of side faces.

Abstract: A micro-electro-mechanical sensing device including a substrate, a semiconductor layer, a supporting pillar, a first suspended arm, a connecting member, a second suspended arm, and a proof mass is provided. The semiconductor layer is disposed on or above the substrate. The supporting pillar is disposed on or above the semiconductor layer. The first suspended arm is disposed on the supporting pillar. The supporting connects a portion of the first suspended arm. The connecting member directly or indirectly connects another portion of the first suspended arm. The second suspended arm has a first surface and a second surface opposite to the first surface. The connecting member connects a portion of the first surface. The proof mass connects the second suspended arm and it includes a portion of the second suspended arm as a portion of the proof mass. A method for manufacturing the device is also provided.

Abstract: An acceleration sensor includes a weight portion having a recess section and a solid section, beam portions, a movable electrode provided on the opposite surface of the weight portion from an open surface of the recess section to extend over the recess section and the solid section, a first fixed electrode arranged at the opposite side of the movable electrode from the recess section, and a second fixed electrode arranged at the opposite side of the movable electrode from the solid section. The acceleration sensor detects acceleration using a change in capacitance between the movable electrode and the fixed electrodes caused by rotation of the weight portion. The beam portions are shifted toward the recess section such that an angle between a perpendicular line extending from a gravity center position of the weight portion to the rotation axis and a surface of the movable electrode becomes equal to 45 degrees.

Abstract: The present invention relates to a method for controlling a scanning probe microscope having a probe (2) with a tip (21) for interacting with a sample (4), and a nanoscanner (1) for retaining the sample (4) or the probe (2), comprising the steps of monitoring the extension of the piezo element (1) along a first direction (R) along which the tip (21) is moved towards the sample (4), and adjusting the level of the probe (2) along the first direction (R) by means of an additional actuator (3), when the nanoscanner (1) exhibits an extension below or above a threshold value. The invention further relates to a device (100) for controlling a scanning probe microscope.

Abstract: A method of operating a metrology instrument includes generating relative motion between a probe and a sample at a scan frequency using an actuator. The method also includes detecting motion of the actuator using a position sensor that exhibits noise in the detected motion, and controlling the position of the actuator using a feedback loop and a feed forward algorithm. In this embodiment, the controlling step attenuates noise in the actuator position compared to noise exhibited by the position sensor in a bandwidth of about seven times the scan frequency. Scan frequencies up to a third of the first scanner resonance frequency or greater than 300 Hz are possible.

Abstract: The present invention is directed to methods for the synthesis of products via mechanosynthesis, including bootstrap means to go from atomically-imprecise to atomically-precise tools, methods for determining reaction sequences for workpieces, and methods for creating new reactions, reaction sequences and tips.