Abstract: An apparatus, control system and methods are disclosed for directly measuring a blood pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors arranged along a length of the distal end portion, for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors, and optionally, a temperature and/or flow sensor, are incorporated into a distal end portion having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers, to an optical coupler at the proximal end of the multi-sensor apparatus, without requiring electrical connections.

Abstract: Techniques, systems and apparatus are described for implementing a heart rate sensor based on optical measurements of color response of human blood. An optical heart rate sensor can include light source circuitry including a first light emitting diode (LED) to output a first source light signal to a target measurement site, a second LED to output a second source light signal to the target measurement site, a first current pulse driver communicatively coupled to the first LED to modulate the first source light signal output from the first LED at a first predetermined frequency and a second current pulse driver communicatively coupled to the second LED to modulate the second source light signal output from the second LED at a second predetermined frequency different from the first predetermined frequency. The optical heart rate sensor can include detector circuitry including a light detecting photodiode connected to a bias voltage.

Abstract: A leadless wireless ECG measurement system for measuring of bio-potential electrical activity of the heart in a patient's body includes at least one multi-contact bio-potential electrode assembly adapted for attachment to the patient's body. The electrode assembly is formed of an electronic patch layer and a disposable electrode layer. The disposable electrode layer has a plurality of contact points for engagement with the surface of the patient's body and is configured to measure short-lead ECG signals in response to electrical activity in the heart. A processing unit is provided and is configured to produce a transfer function which computes estimated long-lead ECG signals based on the measured short-lead ECG signals from the plurality of contact points.

Abstract: The present disclosure provides a system and method of determining a risk score for triage. In particular, a system is provided for providing an assessment of risk of a cardiac event for a patient, for example an incoming patient to a hospital emergency department complaining of chest pain. In the disclosure, the system includes an input device for measuring physiological data based vital signs parameter of the patient, a twelve-lead electrocardiogram (ECG) device for establishing an ECG obtained from results of the electrocardiography procedure, and determining an ECG parameter and a heart rate variability (HRV) parameter therefrom. An ensemble-based scoring system is further provided, establishing weighted classifier based on past patient data and where the vital signs parameter, the ECG parameter and the HRV parameter are compared to corresponding weighted classifiers to determine a risk score. A corresponding method to determine a risk score for triage is also provided.

Abstract: A system and method are provided for identifying a driver of a source associated with a heart rhythm disorder. Data are accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and determine whether the first region controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.

Abstract: Various aspects are directed to identifying a region of interest in a physiological signal. As may be consistent with one or more embodiments, the physiological signal is decomposed into subcomponents, and a subset of the subcomponents is selected based upon overlap of spectral energy with expected spectral energy of the region of interest, in at least one of the subcomponents. At least two of the subcomponents in the subset are combined and compared to a threshold, with the comparison being used to identify the location of the region of interest.

Abstract: An electrode assembly can include a reservoir defining a plurality of openings on a first surface of the reservoir, a wicking material extending through one or more of the plurality of openings, and a conductive terminal. An electrode assembly can include a reservoir cap, a reservoir bottom configured to fit to the reservoir cap and define a reservoir therewith, an electrode disposed within the reservoir, and a wicking element in electrical communication with the electrode and configured to absorb a fluid, wherein at least a portion the wicking element is configured to protrude from the reservoir bottom.

Abstract: An implantable medical device system includes an implantable cardioverter defibrillator (ICD) for detecting and treating ventricular tachycardia (VT). The ICD includes a sensing module for sensing a cardiac signal from available cardiac signal sensing vectors. A control module generates morphology templates of the cardiac signals for multiple patient postures for each of the available sensing vectors and determines a set of posture-independent template features. An unknown cardiac rhythm is classified in response to comparing features of a cardiac signal received during the unknown rhythm to the set of posture-independent features.

Abstract: A system and diagnostic signatures which are derived from the data collected in the system captures multiple streams of biological sensor data for assessing brain health and functionality of a user. The system includes a plurality of biological sensors adapted to collect biological sensor data from the user as well as the ability to stimulate the brain in a variety of sensory, cognitive, physical, and chemical challenges. Several of the biological sensors are accommodated in an electronics module mounted on the user's head.

Abstract: The disclosure provides an apparatus and method for assessing brain plasticity by measuring electrical brain biomarkers, for example, with a near real-time analysis of electrical brain biomarkers, where an increase or decrease in at least one biomarker is indicative of a state of brain plasticity in response to a stimulus or treatment. Brain plasticity can be measured with or without an added stimuli, for example, to determine the best time for learning. Also provided is a method for treating a neurological disease or trauma by applying an electrical or drug stimulus to a patient, where the stimulus is increased or decreased depending on the changes of electrical brain biomarker of the patient. This treatment can occur in near real-time, so a course of treatment can be tailored immediately to a patient's needs.

Abstract: A method of determining microvascular architecture is disclosed. Dynamic contrast-enhanced magnetic resonance data acquired from a contrast agent administered to at least a part of a subject to be examined. From the dynamic contrast-enhanced magnetic resonance data a leakage parameter (kep) and a dispersion parameter (?) are computed. Effects of both convective dispersion and extravasation kinetics of contrast agent are taken into account.

Abstract: A strap-fastening apparatus for fastening safety straps is provided, wherein the strap-fastening apparatus has at least one fastening rail and at least one fastening clip. The at least one fastening clip has a strap-fastening element and the strap-fastening element, in a state of the at least one fastening clip arranged with the at least one fastening rail, is arranged within the at least one fastening rail.

Abstract: An image guiding device for a brain surgery is provided. A computation processing unit receives a non-invasive basic brain image obtained prior to a surgery and plans brain surgical route data. An operating tube enters a brain according to the brain surgical route data. An image capturing module in the operating tube feeds back actual conditions of the brain in real-time. The computation processing unit performs real-time route correction to allow an operating probe to perform operations when the operating tube arrives at a target site. Thus, using the non-real-time non-invasive basic brain image collaborating with a real-time image capturing module, the computation processing unit performs route correction, thereby significantly reducing surgery risks and equipment costs.

Abstract: Implementations disclosed herein provide a method of determining a quantity of an electrochemically convertible substance in a fluid sample, the method comprising introducing the fluid sample into an electrochemical sensor, wherein at least a portion of the fluid sample is electrochemically converted to produce an electrical output from the electrochemical sensor, measuring the electrical output from the electrochemical sensor on a periodic basis to produce sensor measurements, inputting a first subset of the sensor measurements into a first computation to yield first computation analysis results, inputting a second subset of the sensor measurements and the first computation analysis results into a second computation to yield second computation analysis results, and calculating the quantity of the electrochemically convertible substance in the fluid sample by applying a third computation to the first computation analysis results and the second computation analysis results.

Abstract: A data processing method, performed by a computer, for determining a leg length difference and a leg offset difference of a patient's leg including a femur connected to a pelvis, comprising the steps of: —determining a first landmark vector between a femoral landmark and a second landmark at a first point in time; —determining a second landmark vector between the femoral landmark and the second landmark at a second point in time which is later than the first point in time; —calculating an orthogonal projection of the first landmark vector into a sagittal plane and using the direction of the orthogonal projection of the first landmark vector into the sagittal plane as a leg length direction; —calculating a direction which is perpendicular to the sagittal plane and using this direction as a leg offset direction; and —calculating the leg length difference in the leg length direction and the leg offset difference in the leg offset direction from the first landmark vector and the second landmark vector.

Abstract: A monitoring device mounted to a user can be used to estimate a position or orientation of a body portion of the user, such as a joint or jointed portion of the user. Radiation can be emitted toward the body portion and a reflection of this radiation can be received. The reflected radiation can then be used to estimate a position of the body portion of the user.

Abstract: Aspects of automatically determining a period of time when a wearable electronic device is not being worn are discussed herein. For example, in one aspect, an embodiment may automatically determine a period of time when the wearable electronic device is not being worn based on a comparison of the motion data and a not-worn profile that specifies a pattern of motion data that is indicative of when the wearable electronic device is not being worn by a user. The wearable electronic device also stores in the non-transitory machine readable storage medium, data associating the period of time with a not-worn state.

Abstract: A method for measuring the displacements of a vertebral column includes: an initial step, for each vertebra in a segment, including: detection of an initial orientation of the location marker associated with the vertebra, determination of an initial orientation of a vertebral plane parallel to at least one end plate of the vertebra, and a calculation of a geometric transformation associated with the vertebra correlating the initial orientation of the vertebral plane of the vertebrae with the initial orientation of the location marker associated, and; a step measuring displacement of at least one vertebra, including: detection of the current orientation of the location marker associated with the at least one vertebra, and a calculation of the current orientation of the vertebral plane of the at least one vertebra from the current orientation of the location marker associated and the geometrical transformation associated with the at least one vertebra.

Abstract: A kind of safety lancing device has a front cap and lancet holder with feature: the front cap and lancet holder are connected in insert-plug type, and the front cap is equipped with connecting block at connection end and the lancet holder is equipped with slot at connection end. And the slot includes slideable slot and deadlock slot. The slideable slot is located in front of deadlock slot. The latch is set at the flexible arm end of ejection pin and the latch is equipped with bayonet at the front end and equipped with latch hook at rear end; the width of slideable slot and deadlock slot is larger than that of latch; the slideable slot is equipped with a blocking shoulder at rear end and the deadlock slot is equipped with latching shoulder at front end.

Abstract: Non-invasive optical detection devices and techniques that use optically discriminative detection of returned probe light from a target by spatially separating the returned probe light from the deep tissue structure and the returned probe light from the skin surface and the shallow tissue structure based on different wave vector components to improve the optical detection sensitivity in detecting the returned probe light from the deep tissue structure with reduced optical interference by the returned probe light form the skin surface and the shallow tissue structure.

Abstract: An on-body sensor (OBS) (5610) having a continuous monitoring (CGM) device is disclosed for use in identifying an analyte, such as glucose in blood or interstitial fluid (ISF), using a biomaterial, such as glucose binding protein (GBP), that is brought into contact with the analyte. The on-body sensor (5610) incorporating the CGM device includes a housing (5625?) which provides protection to the CGM device while providing comfort to a user wearing the device. The OBS also includes an adhesive structure that provides a comfortable, discreet and secure user experience.

Abstract: Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate. The long-term implantable fluid monitoring system thus includes a first porous catheter, a second porous catheter, a sensor configured to measure an amount of analyte in fluid, and a pump configured to move fluid through the first porous catheter to the sensor and from the sensor through the second porous catheter.

Abstract: A multispectral medical imaging device includes illumination devices arranged to illuminate target tissue. The illumination devices emit light of different near-infrared wavelength bands. The device further includes an objective lens, a near-infrared image sensor positioned to capture image frames reflected from the target tissue, and a visible-light image sensor positioned to capture image frames reflected from the target tissue. A processor is configured to modulate near-infrared light output of the plurality of illumination devices to illuminate the target tissue. The processor is further configured to determine reflectance intensities from the image frames captured by the near-infrared image sensor and to generate a dynamic tissue oxygen saturation map of the target tissue using the reflectance intensities. The device further includes an output device connected to the processor for displaying the dynamic tissue oxygen saturation map.

Abstract: A probe for use in monitoring one or more parameters of a subject is provided. The probe comprises a monitoring assembly comprising at least one acoustic port for transmitting acoustic radiation into a region of interest in the subject, at least one light output port for transmitting incident light towards the region of interest, and at least one light input port for receiving light returned from the subject. The probe comprises also at least one control mechanism comprising at least one sensing assembly configured for sensing at least one of proximity, attachment and signal quality conditions, and being configured for controlling a condition of coupling between the probe assembly and the subject, enabling to control operation of the monitoring assembly.

Abstract: The invention provides a pulse oximetry sensor for attachment to the lower half of the palm or the ulnar edge of the palm. The sensor may be portable, untethered and in some instances, disposable. The features of the sensor make it effective in stable, chronic or emergency medical settings.

Abstract: Remanufactured medical sensors and methods for remanufacturing used medical sensors are provided. Such a remanufactured sensor may include certain components from a used medical sensor and certain new components. For example, a remanufactured regional oximetry sensor may include a padding layer, an emitter and a pair of detectors, a flexible circuit coupled to the emitter and detectors, and a patient-contacting adhesive layer. The flexible circuit, the emitter, the first detector, the second detector, or any combination thereof, are from a used medical sensor, and the padding layer, the patient-contacting adhesive layer, or a combination thereof, are new.

Abstract: A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The transducer component includes the electrode and microprocessor configured to screen noise and to pick up impedance change at a very low frequency range.

Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Abstract: An analytical magazine is proposed, which comprises a plurality of analytical aids accommodated in chambers. The analytical magazine is arranged to be accommodated in at least two orientations in an analytical system. The analytical magazine is furthermore arranged to provide the analytical system, in the orientations, in each case with a plurality of analytical aids. At least one sampling movement can be executed by means of the analytical aids. The analytical magazine is arranged to make a remagazining of the analytical aids possible.

Abstract: A device for taking a sample of liquid by capillarity, including a channel for flow of the liquid delimited by two internal walls of the device between which a channel bottom extends, the distance separating the two internal walls decreasing in the direction of the channel bottom, the channel extending between a first collecting end, open onto outside of the device and configured to receive the liquid, and a second end, to enable the liquid to flow by capillarity along the channel bottom from the first end towards the second end. The channel includes, at the second end, a blocking structure to block the flow of liquid in the channel from the first end towards the second end.

Abstract: A multi lumen catheter comprising a proximal end and distal end said catheter further comprising; a first lumen for a first fluid said first lumen having a first proximal opening and a first distal opening for receiving a fluid, second lumen for a second fluid said second lumen having a second proximal opening and a second distal opening for delivering a second fluid, a third lumen having a third proximal opening and a third distal opening, wherein the first distal opening is arranged with respect to the second distal opening so that when in use at least part of the first fluid which enters the first lumen through the first distal opening has passed across the second distal opening such that the first fluid which enters the first lumen comprise at least a part of the second fluid.

Abstract: A fluid sampling system comprising a housing, a first pump means for withdrawing at least one fluid sample from a first sample site, means for returning at least part of the at one fluid sample to a second sample site, transferring means for transferring at least one volume of the at least one first fluid to a sampling means, second pump means for providing at least one active substance, at least one connection to a reservoir containing the at least one active substance, and at least one energy source for driving at least the first and second pump means.

Abstract: A method of assessing the likelihood that an individual has impulse control disorder. The individual is provided with an actuator, and instructed to actuate the actuator as an acknowledgement of when the individual has completed a reward task. Actuation of the actuator is monitored and recorded. An automated diagnosis of ICD is produced and output, wherein a greater degree of actuation of the actuator by the individual is taken to indicate a greater likelihood that the individual has impulse control disorder.

Abstract: The present invention provides a novel system of hardware designed to capture and process in real time clinical observations of patient responses and reactions in different clinical and patient settings and situations, comprising: a patient biometric data recording system in a clinical office, a mobile real time episode or event data recording device syste or a wearable device recording system.

Abstract: Provided are devices and methods suitable for immobilizing tissue and for use in non-invasive methods of assessing lower urinary tract symptoms as well as in surgical application.

Abstract: A system for measuring physiological aspects has a non-invasive monitor configured to generate monitor signals relating to fluid characteristics in the head and body. A computational device is operatively connected to the monitor and is configured to process the monitor signals to generate characterizing data relating to at least one of regional fluid volumes, intra/extracellular fluid volume ratios and blood flow. A data output device is connected to the computational device and is configured to output the characterizing data. A method and a computer program product for recording, measuring, and displaying physiological characteristics are also provided.

Abstract: A Superconducting Quantum Interference Device (SQUID) magnetic sensor system and method can image organic transplant condition, such as status, acceptance, or rejection, in-vivo. This represents a major advane in transplant imaging technology with a new market for biomagnetic sensor devices. In-vivo transplant condition determination provides a greater range of imaging methodologies over existing methods in sensitivity, and enables early detection of rejection with the ability to determine the need for anti-rejection drugs.

Abstract: A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers.

Abstract: The present invention relates to a vaginal drug delivery and/or diagnostic system, which is connected to a positioning member configured for placement within the vagina. The system comprises an electronic capsule comprising a drug reservoir and means for dispensing the drug from the reservoir into the vagina. The positioning member is for example eight-shaped, pear-shaped or dolphin-shaped and is preferably provided with friction-enhancing means to keep the device in place. The system is particularly useful for systemic administration of drugs and hormones.

Abstract: A physical condition presentation apparatus calculates a point corresponding to an item based on a calculation rule set for the item classified to a behavior executed by a user and interlocked to an index indicating a physical condition of the user and the behavior executed within a predetermined period by the user, and presents presented information including at least one of the calculated point and evaluation of the physical condition of the user according to the point.

Abstract: Systems and methods are disclosed for providing a user an intelligent goal recommendation for an activity level using earphones with biometric sensors. In one embodiment, the system includes earphones, including: speakers; a processor; a heartrate sensor electrically coupled to the processor; and a motion sensor electrically coupled to the processor. In this embodiment, the system also includes a memory coupled to a processor and having instructions stored that, when executed by the processor: monitor a movement of a user based on signals generated by the motion sensor; determine an activity score of the user based on the monitored movement of the user; detect a fatigue level of the user based on signals generated by the heart rate sensor; and display on a display an activity level recommendation based on the user's activity score, detected fatigue level, and a stored archive including historical information about the user's movement and fatigue level.

Abstract: Aspects of changing power consumption of a sensor of a wearable electronic device worn by a user are discussed herein. For example, in one aspect, based on detecting that a state of the user, as tracked by the wearable electronic device, has transitioned into an asleep state, an embodiment may decrease power consumption of at least one sensor from the set of sensors. Additionally, based on detecting that the state of the user, as tracked by the wearable electronic device, has transitioned out of the asleep state, the embodiment may reverse the decrease of power consumption of the at least one sensor.

Abstract: In one aspect, a device includes a processor and a memory accessible to the processor. The memory bears instructions executable by the processor to receive data from a sleep sensor in communication with the device and, based at least in part on the data, determine whether to change a time at which an alarm is to occur at the device.

Abstract: Aspects of automatically detecting periods of sleep of a user of a wearable electronic device are discussed herein. For example, in one aspect, an embodiment may obtain a set of features for periods of time from motion data obtained from a set of one or more motion sensors in the wearable electronic device or data derived therefrom. The wearable electronic device may then classify the periods of time into one of a plurality of statuses of the user based on the set of features determined for the periods of time, where the statuses are indicative of relative degree of movement of the user. The wearable electronic device may also derive blocks of time each covering one or more of the periods of time during which the user is in one of a plurality of states, wherein the states include an awake state and an asleep state.

Abstract: An apparatus for remote contactless monitoring of sleep apnea, comprising a radar transmitter having a transmitting antenna for radiation of radio frequency signal towards a human body, and a radar receiver for receiving a signal reflected from the human body. The radar receiver comprises a receiving antenna positioned at a predefined distance from the transmitting antenna. The apparatus further comprises an accelerometer adapted to be placed on a human body, a microphone and a signal processor. Respective outputs of the radar receiver, accelerometer and microphone are connected to the input of the signal processor which is configured for extracting and processing apnea-specific physiological parameters of the at least one human body from the inputted signals of the receiver, accelerometer, and microphone.

Abstract: Provided herein are systems, methods and devices for performing one or more titrations for oral appliance therapy. For example, a method for evaluating an outcome of oral appliance therapy in a subject is discussed herein. The method can include positioning an adjustable mandibular displacement device in an oral cavity of a subject and implementing an automatic titration protocol. The protocol can include controlling a protrusion level of the adjustable mandibular displacement device during a test period, monitoring physiological information from the subject during the test period, and analyzing the physiological information to evaluate the outcome of oral appliance therapy.

Abstract: A single diagnostic dose of a chemical agent that can bind with molecular specificity or provide a well characterized molecular effect on a mammalian host (including humans) is provided to a patient between brain scans. The method typically comprises at least one pre-dose scan of the subject followed by a waiting period then a second post-dose diagnostic scan. The diagnostic scans can be conventional in nature or of a multi-modal variety. A comparison, in the form of a difference or ratio, between data or extracted features before versus after the diagnostic dose indicates with molecular specificity the tone in the brain of that subject. The resulting data may be used to assess instances of medical fraud and can be used in back to work decisions for brain and soft tissue injuries for which the determinations have traditionally been somewhat subjective in nature.

Abstract: Compositions and methods for diagnosing neurological disorders such as autism spectrum disorders are disclosed.

Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for pre-stent planning, stent planning and post-stent planning using one or more computing devices. In one embodiment, a method generates one or more stent profiles, such as a target stent profile, that are user configurable during a pre-stent planning stage by selecting one or more frames. The method performs a comparative analysis of the previously set target stent profile relative to a vessel lumen region post stent deployment. The method and related user interfaces can alert a user to move, remove, reposition, or inflate a stent. The location of jailed side branches can also be identified and displayed based upon the comparative analysis. Parameters that change based on the outcome of the stent deployment can be displayed in terms of the predicted parameter value and the value that is measured or determined after stent deployment.