Abstract: The present application relates to a method for managing the development and manufacturing process of a therapeutically effective formulation. Peanut proteins are characterized from peanut flour and encapsulated formulations made using the peanut flour for oral immunotherapy of peanut allergies.

Abstract: A feeding apparatus includes a container, a flexible mouthpiece, and a partition. The container includes an open end and defines a main chamber. The flexible mouthpiece defines a secondary chamber in the container and includes a teat. The partition separates the main and secondary chambers and is part of a resiliently biased cartridge. When the flexible mouthpiece and partition are brought together, a flow restrictor is formed. A moveable part of the cartridge is configured to be biased towards a first position by a biasing element, and is moveable against the bias from the first position to a second position. The cartridge at least substantially closes a path for a flow of liquid feed through the flow restrictor and between the main and secondary chambers when the moveable part is in the first position, and opens the path when the moveable part is in the second position.

Abstract: A method for producing a pacifier teat, and a pacifier teat with a teat section which forms a hollow space and which is adjoined by a stem, wherein an elastic hollow body comprising the teat section and the stem is injection moulded or pre-formed by a dipping method, and opposite wall sections of the pre-formed hollow body are connected to each other in the region of the stem.

Abstract: A neonatal enteral feeding system for delivering neonate fluid is disclosed. The system includes a cooling unit for cooling the breast milk before, during and after a feeding cycle to mitigate unwanted bacterial growth and reduction of fat content in the breast milk. The system also includes a warming unit for heating the cold breast milk to a temperature above room temperature (preferably, standard body temperature) so that the neonate can focus his or her energy on healing, growth and digestion instead of heat generation. Additionally, the system has a peristaltic pump which draws the breast milk from a bottom side of the container and the container is vented so as to be capable of delivering all of the breast milk in the container to the neonate.

Abstract: An enteral feeding connector includes a connector body that can be removably attached to a tip of a syringe, which has a component that makes a fluid tight seal with the syringe tip. An air venting stem integrally formed with the component can extend into a barrel of the syringe. An air venting passage extends through the air venting stem and opens in the barrel of the syringe. An enteral fluid passage extends through the component and is in fluid communication with the barrel of the syringe.

Abstract: Problem An object of the present invention is to provide a dental conditioning composition that enhances the adhesiveness of any dental material for a tooth surface by suppressing any excessive demineralization for the tooth surface and improving the polymerization activity of a dental adhesive composition by causing a polymerization catalyst included in the dental conditioning composition of the present invention to remain on the tooth surface. Solution A dental conditioning composition having a gel character, that includes a polymerization catalyst, an acidic compound, water, and a thickening agent, and whose pH (the hydrogen ion exponent) is in a range from 0.1 to 0.9.

Abstract: The present invention discloses a root canal dental paste that has include a first portion made from at least one antibiotic compound and partially set calcium based cement which forms a matrix to at least partially encapsulate the antibiotic compound. The first portion is then ground and combined with a second portion being a non-setting material and an antibiotic to form a paste.

Abstract: A composite material including silanated filler and mixed polymerizable monomer, having a stable pasty property which keeps well and has a consistent usability. A composite material containing a silanated filler, a polymerizable monomer, and a polymerization initiator, and may be produced by a process which includes a mixed polymerizable monomer preparing step, a silanation step, a silanated filler preserving step, a composite material preparing step, a composite material preserving step, a composite material filling step, and a small quantity preserving container preserving step.

Abstract: A dental treatment method is provided. In this method, a tooth of a patient is extracted and prepared to provide a root part. A root canal in the extracted tooth is prepared and treated. A post of an abutment is fitted into the root canal to attach the root part to the abutment. The abutment having the root part is attached to a dental implant. With the root part attached to the abutment, periodontal connective tissue maintains the jaw bone associated with the extracted tooth, without significant hard tissue loss.

Abstract: A composite material including silanated filler and mixed polymerizable monomer, having a stable pasty property which keeps well and has a consistent usability. A composite material containing a silanated filler, a polymerizable monomer, and a polymerization initiator, and may be produced by a process which includes in order of a mixed polymerizable monomer preparing step, a mixed polymerizable monomer preserving step, a composite material preparing step, a composite material preserving step, a composite material filling step, and a small quantity preserving container preserving step.

Abstract: The present invention relates to a dental curing composition to restore a lost portion of a tooth generated due to dental caries, tooth fracturing, etc. PROBLEM To provide a dental curing composition that has packability suitable for restoring a posterior tooth, that has a paste character of avoiding stickiness to a filling instrument, that is excellent in the form shaping property, whose paste character varies little over time, and that has a low polymerization shrinkage property. SOLUTION The problem is solved by a dental curing composition that includes components (a) to (d): (a) a matrix resin whose viscosity at 25° C. is 10,000 to 17,000 mPa·s, (b) an organic-inorganic composite filler, (c) an inorganic filler, and (d) a polymeric initiator.

Abstract: A method of improving the look and feel of skin by using a two-step regimen that includes applying an underlying layer of a skin care composition and applying an overlying layer of a finisher composition on top of the underlying skin care composition layer. The finisher composition is an oil-in-water emulsion comprising a continuous aqueous phase, a dispersed oil phase, and from 10 to 25 wt % of substantially spherical particles. The oil phase includes non-volatile oil that is at least 50 wt % of a liquid UV agent. The spherical particles can be starch particles, silicone elastomer particles or combinations of these. The finisher composition is generally free of glycerin or other humectants.

Abstract: The invention relates to a method of manufacturing a cosmetic article having a decorative embossed and/or debossed surface, based on at least one cosmetic product hot-poured into a container, this method making use of: a receptacle forming said container and having a peripheral wall and a bottom, said receptacle having at least one filling area, each filling area extending from the bottom of said receptacle and having a filling hole and at least one vent hole, and a closure member that cooperates with the receptacle to define an enclosed filling cavity with the at least one filling area, and having an embossed and/or debossed surface adapted to give the cosmetic product poured into said cavity an embossed and/or debossed surface, said method comprising at least the following steps: a) positioning the receptacle on the closure member so that the embossed and/or debossed surface extends into the filling area; b) hot-injecting the cosmetic product into the filling cavity by means of a filling head inserted in th

Abstract: A surface working method of a cosmetic make-up product comprising the step of setting the cosmetic product in rotation about an axis of symmetry thereof and, simultaneously, moving a cutting tool above the surface of the cosmetic product so as to remove at least a part of said surface, thus giving the surface a predetermined shape. The finding also relates to a device for implementing said method and a cosmetic product made with such a device.

Abstract: A method for producing make-up elements (1) involves mixing at least some pigments/beads, a filler and a binder to obtain a make-up powder (2) pressing the make-up powder (2) on a first surface (23) of a matrix (20) having a plurality of through holes (21), thus pushing the make-up powder through a first end of said holes to form a plurality of strips (L) which protrude from a second end of the holes (21) disposed on a second surface (24) of the matrix (20), and breaking the plurality of strips (L) in the proximity of said second surface, so as to form a plurality of make-up elements (1); the invention also relates to a make-up element and to a cosmetic make-up product.

Abstract: The present invention relates to a composition comprising, in a cosmetically acceptable medium: a) composite particles with a mean size of greater than 0.1 ?m, containing a matrix comprising i) at least one organic material and/or at least one mineral material and ii) at least titanium dioxide; and b) hydrophobic silica aerogel particles. The invention also relates to a cosmetic process for caring for and/or making up human keratin materials, especially bodily or facial skin or the hair, comprising at least the application, to the surface of the keratin material, of a composition as defined previously. The invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of a composition as defined previously.

Abstract: The present invention relates to new (foodgrade) solid lipid nanoparticles, as well as the production of such solid lipid nanoparticles and the use of them.

Abstract: An dual oral composition is provided having a first peroxide-containing component and a second bicarbonate-containing component having exceptional anti-plaque and antibacterial action with re-mineralization properties

Abstract: Disclosed are compositions comprising at least one bicarbonate compound, at least one acid, at least one film forming polymer, and at least one cosmetically acceptable carrier, wherein the weight ratio of the at least one bicarbonate compound to the at least one acid is greater than or equal to about 1:1, and methods of altering the shape of keratin fibers comprising contacting the fibers with the compositions.

Abstract: Methods for use in selectively conditioning and remineralizing teeth. An exemplary method comprises the steps of applying a conditioning composition to one or more of a person's teeth, and separately applying a remineralizing composition to the person's teeth. The conditioning composition includes a conditioning agent, and the remineralizing composition includes a remineralizing agent comprising calcium ions and/or fluoride ions. The conditioning composition may be applied prior to or after application of the remineralizing composition. In one embodiment, both the conditioning composition and the remineralizing composition include different remineralizing ions (e.g., one including calcium, one including fluoride).

Abstract: The present invention is directed to alkoxylated alcohol alkyl ethers. In some embodiments, these ethers include a very short chain ether end cap, such as a methyl or ethyl group. In some embodiments, the long chain fatty alcohol used is unsaturated and/or branched. In some embodiments, a compound of the invention includes: R1O—(PO)n—R2??(Formula Xa) wherein P is a branched alkyl group having 3 carbons; n is an integer ranging from 2 to 10; R1 is a branched or unsaturated hydrocarbon having 16 to 24 carbons which are substituted or unsubstituted; and wherein R2 is a methyl group. In some embodiments, n is 3 and R1 is an isostearyl group.

Abstract: A method for removing a radiation-polymerized cosmetic coating from nails comprising applying a solvent system comprising a hydroxyl-containing solvent and a non-hydroxyl-containing solvent to a polymerized nail coating. A two package system comprising a first package comprising polymerizable nail coating composition comprising a (meth)acrylic oligomer, (meth)acrylic monomer, or a mixture of a (meth)acrylic oligomer and a (meth)acrylic monomer, and a photoinitiator, wherein the oligomer or monomer has an acidic or basic ionizable group and a second package comprising a solvent system for removing the polymerizable nail coating composition after it has been applied to a nail and radiation cured, the solvent system comprising a hydroxyl-containing solvent and a non-hydroxyl-containing solvent. A radiation-curable coating composition for human nails is also disclosed.

Abstract: A liquid anti-aging antioxidant nutritional supplement comprising collagen, carnosine, CoEnzyme Q10 and Resveratrol particularly suitable for reducing oxidative damage to the integumentary system.

Abstract: Disclosed are methods for improving the improving the manageability of keratin fibers such as hair involving providing compositions comprising at least one bicarbonate compound, at least one acid, and at least one cosmetically acceptable carrier, wherein the weight ratio of the at least one bicarbonate compound to the at least one acid is greater than or equal to about 1:1.

Abstract: A finisher composition in the form of an oil-in-water emulsion. The continuous aqueous phase of the emulsion is from about 20 to 85 wt % of water. The dispersed oil phase of the emulsion includes a non-volatile oil, which is at least 50% by weight of a liquid UV agent. The composition also includes from about 10 to 25 wt % of substantially spherical starch particles, silicone elastomer particles, or a combination of these. The particles have a particle size of from about 2 to 40 microns. The weight ratio of the non-volatile oil to the particles is from about 1:10 to about 1:1. The composition is substantially free of glycerin and, optionally, includes from about 1 to 20 wt % of a volatile oil.

Abstract: A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.

Abstract: The antimicrobial foaming composition of the present invention comprises a cationic active ingredient, a cationic compatible surfactant, a foam booster, a foam structure enhancing agent, dermal adjuvants, and a carrier. The present antimicrobial compositions are free of the antimicrobial agents triclosan (i.e., 2,4,4?-trichloro-2?hydroxy-diphenylether) and lower alcohols. They are also free of anionic surfactants. The foaming compositions have rapid cidal activity, provide stable, copious foam, and exhibit enhanced tissue (e.g. skin) compatibility.

Abstract: Combination sunscreen and insect repellant compositions are disclosed. Methods of making and using combination sunscreen and insect repellant compositions are also disclosed.

Abstract: The present invention provides compositions comprising from about 0.01 to about 3% by weight of the composition of one or more N?-acyl acidic amino acid ester salts represented by the formula I: wherein R1 is an alkyl group having from 1 to 8 carbons, R2 is an alkyl group having from 6 to 30 carbons, n is from 1 to 6 and X? is an anion; a zwitterionic surfactant; an alcohol represented by R3—OH, wherein R3 is an alkyl group having from 2 to 6 carbons; an aqueous vehicle; and an oily component, wherein the composition has a pH of less than 7. Also provided are methods of inhibiting plaque in an oral cavity comprising the step of introducing a composition of the present invention into the oral cavity and dispensing devices containing compositions of the present invention.

Abstract: The present invention provides compositions comprising from about 0.01 to about 3% by weight of the composition of one or more N?-acyl acidic amino acid ester salts represented by the formula I: wherein R1 is an alkyl group having from 1 to 8 carbons, R2 is an alkyl group having from 6 to 30 carbons, n is from 1 to 6 and X? is an anion; a zwitterionic surfactant; an alcohol represented by R3—OH, wherein R3 is an alkyl group having from 2 to 6 carbons; an aqueous vehicle; and an oily component, wherein the composition has a pH of less than 7. Also provided are methods of inhibiting plaque in an oral cavity comprising the step of introducing a composition of the present invention into the oral cavity and dispensing devices containing compositions of the present invention.

Abstract: Provided are compositions, e.g., oral and personal care products, comprising (i) a tetrabasic zinc-amino acid or trialkyl glycine-halide complex, and (ii) cysteine in free or in orally or cosmetically acceptable salt form, together with methods of making and using the same.

Abstract: The present invention provides personal care compositions having efficient perfume blooms or bursts. The personal care compositions include shampoo and body wash compositions, and comprise perfume materials having high perceived odor intensity at low concentrations of perfume materials.

Abstract: The present invention provides compositions containing one or more calcium sequestration agents and methods for topical application of such compositions to the skin to treat skin pigmentation disorders, such as melasma, post-inflammatory hyperpigmentation, pigmentation changes due to skin aging, or any other skin conditions related with normal such as skin of color or abnormal pigmentation such as hypo- or hyper-pigmentation in humans.

Abstract: Surfactin is a biosurfactant produced by Bacillus subtilis and is a natural cycloaliphatic peptide having a ring structure made of 7 amino acids. The surfactin has various functions including anti-aging, anti-wrinkle, increasing skin penetration of cosmetic products (skin penetration agent), foaming agent, and emulsifier.

Abstract: This document provides methods and materials for delivering compounds to teeth and methods and materials for providing teeth with a whiter appearance. For example, methods and materials are provided for contacting teeth with one or more adhesive molecules (e.g., mussel adhesive polypeptides or polymer containing a plurality of 3,4-dihydroxyphenyl-L-alanine residues) in combination with one or more fluorescence emitting polypeptides (e.g., a blue fluorescent protein (BFP)) and/or whitening particles to provide the teeth with a whiter appearance.

Abstract: Surfactin is a biosurfactant produced by Bacillus subtilis and said surfactin is a natural cycloaliphatic peptide comprising a ring structure made of 7 amino acids, and said surfactin has various functions including anti-aging, anti-wrinkle, increasing skin penetration of cosmetic products (skin penetration agent), foaming agent and emulsifier.

Abstract: A composition for topical application to dermal papilla cells associated with keratin fibers from scalp, eyelashes or eyebrows comprising at least one OGG1 DNA repair enzyme, and method for treating dermal papilla cells associated with keratin fibers to inhibit oxidative damage, stimulate melanin synthesis, and reduce apoptosis.

Abstract: Soluble fluoride ion stability is increased in certain dentifrice formulations with the use of carrageenan, particularly under alkaline pH conditions.

Abstract: Non-toxic consumable compositions and formulations having chelator and base are disclosed with synergistic effects on microbial metabolism and/or growth and/or pathogenic effectors and their use to promote and maintain health in mammals. The non-toxic consumable compositions have more than one chelator and/or more than one base. Methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used are also disclosed. The synergistic compositions and methods can be used for maintaining health, promoting health and treating diseases.

Abstract: A water-absorbing polymer obtained from (A) a phosphate-containing (meth)acrylic monomer and/or a salt thereof, (B) a monomer having one (meth)acrylic group within the molecule and/or a salt thereof other than component (A), and (C) an organopolysiloxane having a (meth)acrylic group at both ends and related compositions.

Abstract: In one aspect, hair conditioning compositions are described herein. In some embodiments, a hair conditioning composition comprises a polymer or oligomer comprising (A) at least one hydrophilic block comprising an alkoxylated diol or amine-terminated derivative thereof and (B) at least one hydrophobic block comprising a condensation reaction product of (i) a dicarboxylic acid or dicarboxylic acid equivalent and (ii) a diamine, amino alcohol, diol, or combination thereof. The hydrophilic block (A) and the hydrophobic block (B) are bonded together through an amide or ester linkage. In addition, the polymer or oligomer comprises at least one amide moiety.

Abstract: Disclosed are oral care compositions comprising an abrasive system, wherein the abrasive system comprises (a) a first particulate abrasive comprising at least 20 wt % pumice, based on the weight of the oral care composition, having an average particle size of from 20 to 300 microns; and (b) a second particulate abrasive comprising calcium carbonate having an average particle size of from 2 to 13 microns. There is also disclosed a method of cleaning teeth comprising applying the oral care composition to a tooth surface, the oral care composition being applied as a paste disposed in a prophy cup.

Abstract: The present invention relates an oral care composition, comprising one or more functional agents selected from a group consisting of a whitening agent, a re-mineralizing agent, an anti-plaque agent, an anti-gingivitis agent, a detoxifying agent and its combinations. The composition further comprises a probiotic blend consisting of beneficial oral bacterial population and at least one essential oil comprising antimicrobial activity.

Abstract: Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5? triphosphate, 2? fluoro-modified pyrimidine non-linear single stranded RNA at least 17 nucleotides long with a least 3 base pairings or a 5? triphosphate, 2? fluoro-modified double stranded RNA at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. The subject may have a proliferative disorder or infectious disease and administration of the compositions provided herein may treat the disorder or disease.

Abstract: A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

Abstract: Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use are disclosed.

Abstract: A process for the preparation of an oral disintegrating tablet comprising the antihypertensive telmisartan and the tablet obtained by the process.

Abstract: This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active risperidone at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of risperidone to tissues or organs.

Abstract: The invention provides pharmaceutical stable semisolid topical compositions comprising between 0.2 to 5% of a des-fluoroquinolone compound, and a suitable carrier to manufacture an ointment or a cream.