Patents Issued in February 18, 2016
  • Publication number: 20160045405
    Abstract: A silicone composite particle composed of a silicone rubber particle and a polyorganosilsesquioxane, wherein the silicone rubber particle has plural dents on its surface and the polyorganosilsesquioxane adheres to the surface of the silicone rubber particle. Also, a method for preparing the silicone composite particle, which includes steps of subjecting organotrialkoxysilane to a hydrolysis and subsequent condensation in the presence of water, an alkaline substance and a silicone rubber particle containing therein a liquid to thereby have a resultant polyorganosilsesquioxane adhered to the surface of the silicone rubber particle, and subsequently removing the liquid.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Yoshinori INOKUCHI
  • Publication number: 20160045406
    Abstract: A method of manufacture of an anhydrous cosmetic composition comprising the mixing of dried calcium chloride with liquid carrier material and fragrance comprising a solvent to give a give a base composition, followed by the gassing of the base composition with a propellant to give an aerosol composition, wherein the fragrance and the solvent therein are pre-mixed and this mixture comprises one or more components having a log P of greater than 5.5 and a vapour pressure at 25° C. of less than 0.001 mm Hg (0.1333 Pa) and does not comprise dipropyleneglycol at 3% or greater of this mixture; the method enhancing the homogeneity and stability of the composition.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 18, 2016
    Applicant: CONOPCO, INC., D/B/A UNILEVER
    Inventors: Michael Richard BAKER, Neil Robert FLETCHER, Kevin Ronald FRANKLIN, Joanne Elizabeth STOCKTON
  • Publication number: 20160045407
    Abstract: A dentifrice composition is provided. The dentifrice composition can include a multi-stage composition adapted to provide incremental chemistries during use.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventor: Paul Albert Sagel
  • Publication number: 20160045408
    Abstract: An oral care regimen where a user applies a first oral composition and a second composition to the oral cavity. The first composition can be a dentifrice and can contain stannous fluoride and the second composition can be a gel and can contain hydrogen peroxide. The regimen can provide a long-lasting clean feeling.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventor: Paul Albert Sagel
  • Publication number: 20160045409
    Abstract: A topically administrable composition comprises an aqueous suspension (e.g. a quick-drying aqueous solution), said aqueous suspension having disposed there within amphiphilic micro-particles having diameters in the range of 1-100 ?m, wherein said aqueous suspension comprises: A. hydrophobic nanoparticles of modified metal oxide and/or modified silicon oxide having diameters in the range of 1-150 nm; B. hydrophilic nanoparticles of metal oxide and/or silicon oxide having diameters in the range of 1-150 nm; and C. gas bubbles which are bounded by an internal layer of said hydrophobic nanoparticles and an external layer of said hydrophilic nanoparticles. In some embodiments, the gas-bubbles are air-bubbles.
    Type: Application
    Filed: April 25, 2014
    Publication date: February 18, 2016
    Inventors: Dov INGMAN, Erez MANOR
  • Publication number: 20160045410
    Abstract: An inventive composition for the treatment of hyperhidrosis comprises an active ingredient, namely aluminum chloride in the range of 14.25% to 15.75% by weight and water in the range of about 75% to 80% by weight. The solution of the inventive composition is applied to a body via a pre-soaked towelette by dabbing the towelette over the parts of the body susceptible to excessive sweating. The composition includes a skin protein that binds with the active ingredient to effectively block the pores and sweat glands to control excessive perspiration. The solution of the composition is applied in the evening before bedtime, and immediately after showering in hot water, so that the pores are most receptive to the solution and the composition effectively blocks the pores.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 18, 2016
    Inventor: Michael Brier
  • Publication number: 20160045411
    Abstract: Provided are a silicon-oxide-coated zinc oxide capable of suppressing the elution of zinc ions from zinc oxide particles, a method for manufacturing the same, a silicon-oxide-coated-zinc-oxide-containing composition, and a cosmetic. The silicon-oxide-coated zinc oxide is a silicon-oxide-coated zinc oxide formed by coating the surfaces of zinc oxide particles with a silicon oxide coating, in which the average particle diameter of the zinc oxide particles is in a range of 1 nm or more and 50 nm or less, when the abundance ratio of silicon in the silicon oxide coating in a Q3 environment is indicated by Q3, and the abundance ratio in a Q4 environment is indicated by Q4, Q3+Q4?0.6 and Q4/(Q3+Q4)?0.5, and furthermore, the decomposition ratio of Brilliant Blue generated by the photocatalytic activity of the zinc oxide particles is 3% or less.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 18, 2016
    Inventors: Tetsuro ITAGAKI, Yoshiki KUSAHARA, Gaku FUJIHASHI, Syunsuke SUMA
  • Publication number: 20160045412
    Abstract: A topical, over the counter, all natural, organic, antifungal, antibacterial cream having superior moisturizing and water repellency performance that absorbs into the epidermis without spreading thereby eliminating and preventing the growth of the rash-causing fungus that causes diaper rash, and other skin irritation rashes.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 18, 2016
    Inventor: Matthew P. Davies
  • Publication number: 20160045413
    Abstract: The present specification discloses fluid compositions comprising a matrix polymer and stabilizing component, methods of making such fluid compositions, and methods of treating skin conditions in an individual using such fluid compositions.
    Type: Application
    Filed: August 19, 2015
    Publication date: February 18, 2016
    Inventor: Pierre F. Lebreton
  • Publication number: 20160045414
    Abstract: Provided is a composition containing, as an alkane polyol, a C4-18 1,2-alkane polyol in which the degradation over time of the C4-18 1,2-alkane polyol, which has inferior chemical stability and degrades easily, is suppressed, the composition being suitable for use in a cosmetic, an inkjet ink, a fiber or a coating material such as a paint. A composition containing 1,2-alkane polyol that can be used in a cosmetic, an inkjet ink, a raw material for fibers or a coating material, the alkane polyol being a C4-18 1,2-alkane polyol, and the composition containing a radical scavenger.
    Type: Application
    Filed: October 9, 2015
    Publication date: February 18, 2016
    Applicant: OSAKA ORGANIC CHEMICAL INDUSTRY LTD.
    Inventors: Yutaka Hoshino, Takahiro Mukaiyama
  • Publication number: 20160045415
    Abstract: 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.
    Type: Application
    Filed: April 4, 2014
    Publication date: February 18, 2016
    Inventors: Tomoyuki NISHIZAKI, Akito TANAKA
  • Publication number: 20160045416
    Abstract: Compositions, formulations, methods, and kits for treating regional fat deposits and fat-related conditions. Certain methods comprise administering the formulations described herein that comprise ethanolamine, an ethanolamine-like compound, or pharmaceutically or cosmetically acceptable salt, solvate, prodrug, or ester thereof and a liquid carrier.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventor: John Daniel DOBAK
  • Publication number: 20160045417
    Abstract: A cleaning cosmetic composition includes, in a cosmetic carrier, a) at least one anionic surfactant (A), b) at least one amphoteric surfactant (B), c) at least one C2-C4 mono- and/or dialkanolamide (C) of at least one C8-C24 carboxylic acid, d) at least one native oil (D), and e) at least one cationic Polysaccharide (E), characterized in that i) the weight ratio of the anionic surfactant (A) to alkanolamide (C) is 15:1 to 7:1, and ii) the weight ratio of the amphoteric surfactant (B) to alkanolamide (C) is 12:1 to 5:1.
    Type: Application
    Filed: October 27, 2015
    Publication date: February 18, 2016
    Inventors: Thomas Schroeder, Dirk Hentrich, Marine Wassen
  • Publication number: 20160045418
    Abstract: A cleaning cosmetic composition includes, in a cosmetic carrier, a) at least one anionic surfactant (A), b) optionally, an amphoteric surfactant (B), c) at least one sorbitan acid ester (C), and d) at least one cationic polysaccharide (D).
    Type: Application
    Filed: October 27, 2015
    Publication date: February 18, 2016
    Inventors: Thomas Schroeder, Dirk Hentrich, Marine Wassen
  • Publication number: 20160045419
    Abstract: A personal care photoprotective composition is provided having a UV-A and UV-B sunscreen in conjunction with a tricyclodecane amide. The tricyclodecane amide functions to boost UV-A, UV-B and SPF performance when the personal care composition is applied to skin or hair of the human body.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 18, 2016
    Applicant: Conopco, Inc., d/b/a Unilever
    Inventors: Van AU, Bijan HARICHIAN, Ian Stuart CLOUDSDALE, John Steven BAJOR, John Kenneth DICKSON, JR.
  • Publication number: 20160045420
    Abstract: The invention relates to a cosmetic process for depigmenting, lightening and/or whitening keratin materials, in particular the skin, which comprises the application of a cosmetic composition comprising a compound of formula (I): or its tautomer form of formula (I?): in which: R1 and R2, which may be identical or different, denote a radical chosen from: a) a hydrogen atom; b) a C1-C20 alkyl group optionally interrupted with N, S or O, optionally substituted with one or more group(s) chosen from —OR3, —SR3, —NR3R4, —CONHR3; -COOR3; and an aryl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; c) a C1-C8 alkyl group substituted with a C5-C12 aryl radical optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; d) a phenyl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; R3 denoting H or a C1-C5 alkyl group, R4 denoting H, a C1-C5 hydrocarbon-based grou
    Type: Application
    Filed: July 21, 2015
    Publication date: February 18, 2016
    Applicant: L'OREAL
    Inventor: Xavier MARAT
  • Publication number: 20160045421
    Abstract: Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Joe Vazquez, Dandan Chen, Harsh M. Trivedi, Ammanuel Mehreteab, Laurence Du-Thumm, Gregory Szewczyk, Zhigang Hao
  • Publication number: 20160045422
    Abstract: Provided are compositions comprising a gloss agent having a refractive index of 1.4 or greater, an emollient film facilitator having a viscosity of 300 cPs or greater, and a film-forming polymer, wherein the composition comprises a greater amount, on a weight percent basis, of emollient film facilitator than gloss agent. Also provided are methods of providing radiance to the skin by applying to the skin a composition of the present invention.
    Type: Application
    Filed: May 14, 2012
    Publication date: February 18, 2016
    Applicant: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Samuel HUANG, Lydia ZENG, Amigo GU, Linda ZHANG, Jiang WU
  • Publication number: 20160045423
    Abstract: Exopolysaccharide of a bacterial strain for use in treatment and/or care of the skin, mucous membranes, hair and/or nails, as well as its cosmetic and/or dermopharmaceutical compositions. In particular, for the aging of skin and in particular for the treatment and/or prevention of wrinkles.
    Type: Application
    Filed: March 21, 2014
    Publication date: February 18, 2016
    Inventors: Raquel DELGADO GONZÁLEZ, Albert SOLEY ASTALS, Anthony COURTOIS, Bertrand THOLLAS
  • Publication number: 20160045424
    Abstract: The present invention relates to formulations comprising certain copolymers and at least one surfactant selected from the group consisting of sulphosuccinates and biosurfactants.
    Type: Application
    Filed: April 3, 2014
    Publication date: February 18, 2016
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Peter SCHWAB, Uta KORTEMEIER, Christian HARTUNG, Ursula WESTERHOLT, Silke LANGER
  • Publication number: 20160045425
    Abstract: A cleaning cosmetic composition includes, in a cosmetic carrier, a) at least one anionic surfactant (A), b) at least one amphoteric surfactant (B), c) at least one C2-C4 mono- and/or dialkanolamide (C) of at least one C8-C24 carboxylic acid, d) at least one polydimethylsiloxane (D), and e) at least one cationic polysaccharide (E), characterized in that i) the weight ratio of the anionic surfactant (A) to alkanolamide (C) is 15:1 to 7:1; and ii) the weight ratio of the amphoteric surfactant (B) to alkanolamide (C) is 12:1 to 5:1.
    Type: Application
    Filed: October 27, 2015
    Publication date: February 18, 2016
    Inventors: Thomas Schroeder, Dirk Hentrich, Marine Wassen
  • Publication number: 20160045426
    Abstract: The present invention relates to process for preparing cosmetic compositions at two stages. The first relates to the preparation of organogels in which liquid oils are structured by a mixture of structuring agents such as monoglycerides and waxes, which also have the addition of other components such as polymers and polyol esters. The second step is the formation of the cold or hot process cosmetic compositions where emulsions are prepared by the addition of water, aqueous solutions and other components, to the organogel. The emulsions prepared have superior sensory, chemical-physical and stability characteristics, to those currently produced by the classic technology of preparation with emulsifiers.
    Type: Application
    Filed: March 22, 2013
    Publication date: February 18, 2016
    Inventors: Cecilia NOGUEIRA, Cristiane Rodrigues da Silva PACHECO, Daniel Barrera ARELLANO, Daniele Cristina Zulim BOTEGA, Mario Luiz MATHIAS NETTO
  • Publication number: 20160045427
    Abstract: A make-up composition is for the skin, is prepared by a process and used in a makeup method. The cosmetic composition is intended for making up the skin. The composition has from 75 to 98% by weight of a powder or a mixture of powders, as well as at least one cosmetically acceptable fatty phase having at least one oil. The composition additionally includes a block copolymer of at least one styrene polymer and of at least one olefin polymer, the olefin being other than styrene, or a mixture of these block copolymers.
    Type: Application
    Filed: October 30, 2015
    Publication date: February 18, 2016
    Inventors: Sabine VIC, Murielle FARIGOULE, Brigitte NOE, Eric PERRIER
  • Publication number: 20160045428
    Abstract: The present invention discloses the use of a ginseng and tuber fleeceflower root complex polysaccharide in the preparation of health-care food having anti-aging efficacies, the complex polysaccharide is ginseng and tuber fleeceflower root complex polysaccharide, with ginseng and/or tuber fleeceflower root as raw material, the complex polysaccharide is obtained by water extraction, concentration and alcohol precipitation processes. The complex polysaccharide in the present invention, as proved by Caenorhabditis elegans model experiment, is able to prolong the average life span of wild-type, oxidation stress model and protein aggregation toxin model effectively, the effect pathway is closely related to improving anti-oxidation ability in C. elegans, inhibiting toxic aggregation protein stress, enhancing the activity of heat-block protein and regulating the crucial node of insulin signalling pathway, which demonstrates that it has good effect of delaying aging and preventing aging-related diseases.
    Type: Application
    Filed: February 6, 2015
    Publication date: February 18, 2016
    Applicant: Infinitus (China) Company Ltd.
    Inventors: Minghua HU, Ming LIANG, Haifeng LI, Fangli MA
  • Publication number: 20160045429
    Abstract: The present invention relates to non-edible coatings comprising a filmogen agent and at least one food material selected from liquid, solid, fluid or gel food materials such as for example water, citrus fruit, red berries, raspberry, strawberry, blackberry, kiwifruit, tomato, vanilla, pomegranate, beet, carrot, leek, potato, pimento, saffron, curry, cinnamon, vanilla, fish eggs, lavender, rice, sugar, herbes de provence, tomato concentrate, tomato extract, ketchup, honey, blackberry marmalade, strawberry marmalade, cocoa, chocolate, carrot puree, grenadine, soy sauce, veggies sauce, wine, liquors, curacao, vinegar, tomato juice, carrot juice, raspberry juice, water, milk, rose water or mixture thereof. The method for manufacturing the same is also disclosed.
    Type: Application
    Filed: March 21, 2014
    Publication date: February 18, 2016
    Inventor: Valérie ANNE
  • Publication number: 20160045430
    Abstract: The invention provides sublingual formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof. The invention further provides sublingual formulations containing buprenorphine and naloxone, pharmaceutically acceptable salts thereof or derivatives thereof.
    Type: Application
    Filed: October 27, 2015
    Publication date: February 18, 2016
    Inventors: Kiran P. Amancha, Chandeshwari S. Chilampalli, Venkat R. Goskonda
  • Publication number: 20160045431
    Abstract: An enzymatically-active ribonuclease is combined with a vehicle that does not unacceptably interfere with such enzymatic activity and applied externally. Advantageously, the ribonuclease is ranpirnase. The vehicle can be a liquid, a gel, an ointment, or a serum, and can also be an approved sexual lubricant.
    Type: Application
    Filed: July 8, 2015
    Publication date: February 18, 2016
    Applicant: Tamir Biotechnology, Inc.
    Inventors: Jamie Sulley, Luis Squiquera
  • Publication number: 20160045432
    Abstract: Medical article are described, comprising a lens and a pharmaceutical composition incorporated into the lens, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial agent (such as moxifloxacin), a therapeutically effective quantity of an anti-inflammatory agent (such as prednisolone) and at least one pharmaceutically acceptable excipient. Methods for fabricating the medical articles and using them are also described.
    Type: Application
    Filed: August 12, 2014
    Publication date: February 18, 2016
    Applicant: IMPRIMIS PHARMACEUTICALS, INC.
    Inventors: Gary Seelhorst, Thomas Harvey, Mark L. Baum
  • Publication number: 20160045433
    Abstract: A children's medication delivery device for delivering liquid medication to a young child in a form that is palatable and attractive to facilitate administering medication to the child. The device includes a shell comprising a gummy candy composition. The shell defines an interior space within the shell. A medication is positioned in the interior space of the shell wherein the medication is enclosed by and contained in the shell.
    Type: Application
    Filed: August 13, 2014
    Publication date: February 18, 2016
    Inventor: Debbie Whitney
  • Publication number: 20160045434
    Abstract: The present invention relates to inhalation formulations of drugs in the form of dry powder for inhalation administration deliverable as such with an inhaler and provided with high deliverability, respirability and stability. In particular, the invention relates to a pharmaceutical composition for inhalation in the form of powder comprising at least a first and a second powder, in which at least said first powder contains an active agent in an amount greater than 1% by weight with respect to the weight of said first powder. Both the powders comprise leucine in an amount ranging from 5 to 70% by weight with respect to the weight of each powder and a sugar in an amount ranging from 20 to 90% by weight with respect to the weight of each powder. The composition has a fine particle fraction (FPF) greater than 60% and a delivered fraction (DF) greater than 80.
    Type: Application
    Filed: April 9, 2014
    Publication date: February 18, 2016
    Applicant: ERATECH S.R.L.
    Inventors: Giovanni Caponetti, Loretta Maggi, Cristina Veneziani, Paolo Ventura, Laura Zanellotti
  • Publication number: 20160045435
    Abstract: The present invention concerns a method for making an inhaled pharmaceutical composition with improved powder handling properties comprising a stearate, a method of preparing such a composition, and the use of such a stearate in a composition when dispensed into a receptacle for use in a dry powder inhaler receptacle.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 18, 2016
    Inventor: MATTHEW GREEN
  • Publication number: 20160045436
    Abstract: The present invention relates to pharmaceutical formulations of highly active drugs with limited shelf-life in aqueous media, suitable to be administered by a caregiver person to a patient avoiding or minimizing the risk of exposure, contact or contamination of the caregiver person with the active product ingredient (API), preferably an EGFR-TKI such as afatinib dimaleate.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventors: Detlef MOHR, Florian SOMMER
  • Publication number: 20160045437
    Abstract: The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including celecoxib and plumbagin in combination; methods for treatment of a proliferative disease including administration of celecoxib and plumbagin in a subject in need thereof; and particularly methods for treatment of skin cancer including administration of celecoxib and plumbagin in a subject in need thereof.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 18, 2016
    Inventors: Gavin P. Robertson, Chandagalu D. Raghavendra, Arati K. Sharma, Gregory Kardos, Sanjay Singh
  • Publication number: 20160045438
    Abstract: This invention relates to a granulate comprising mannitol and sorbitol in a weight ratio of between 70:30 and 97:3. This invention also relates to the use of the said granulate in the preparation of orodispersible tablets, to the orodispersible tablets obtained with the said granulate and to a process of production for obtaining the said granulate.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 18, 2016
    Applicant: E-PHARMA TRENTO S.p.A.
    Inventors: Massimiliano ROSSI, Riccardo CATALANO, Silvia BOSCHETTI, Paolo ANDREATTA
  • Publication number: 20160045439
    Abstract: Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-? signaling and a biodegradable carrier. Further provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of modulating MCP-1 signaling and a biodegradable carrier. Methods of treating inflammation in a subject having a spinal cord injury and kits for producing the compositions are also disclosed.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventors: JASON M. CRISCIONE, FRANCIS M. REYNOLDS, HAINING DAI
  • Publication number: 20160045440
    Abstract: The present invention relates to a dosage form which comprises amorphous calcium L-5-methylfolate and cysteine as stabilizing agent and optionally, further auxiliary agents. The dosage forms according to the invention resolves the problem of instability of amorphous calcium L-5-methylfolate to the oxidation by air.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 18, 2016
    Inventors: Gonzalo HERNANDEZ HERRERO, Celestino RONCHI, Isabel DÍAZ DEL CONSUELO
  • Publication number: 20160045441
    Abstract: The invention relates to a pharmaceutical formulation comprising 40-O-(2-hydroxy)ethyl-rapamycin in a high drug load part and an immediate release part. In addition, the invention relates to a formulation comprising 40-O-(2-hydroxyethyl-rapamycin in a first layer and a surfactant in a layer beneath the first layer. The pharmaceutical composition is particularly suitable for use as a medicament.
    Type: Application
    Filed: March 19, 2014
    Publication date: February 18, 2016
    Applicant: Novartis AG
    Inventors: Anke DIEDERICH, Hans-Ulrich KUNZLER, Oliver Graner
  • Publication number: 20160045442
    Abstract: The present invention relates to stable pharmaceutical compositions of mesalamine. The composition of the invention is a capsule dosage form filled with a tablet. The invention also relates to process for preparing such compositions. The invention specifically relates to a composition of mesalamine wherein the composition is devoid of any reducing sugar or sugar alcohol.
    Type: Application
    Filed: August 13, 2015
    Publication date: February 18, 2016
    Inventors: Brij Khera, Sushrut Krishnaji Kulkarni, Hothur R. Kiran
  • Publication number: 20160045443
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Tatyana DYAKONOV, Derek BUSH, Saujanya L. GOSANGARI, Yang Hue CHUE, Shingai MAJURU, Aqeel FATMI
  • Publication number: 20160045444
    Abstract: Provided is a composite formulation comprising: (i) a core including a first pharmacological component; and (ii) a film coating layer formed on a surface of the core, which contains rosuvastatin or a pharmaceutically acceptable salt thereof as a second pharmacological component and a polyvinyl alcohol-polyethylene glycol graft copolymer and polyvinyl alcohol as a coating material. In the composite formulation of the present invention, tension and fluidity of the film coating layer are excellent, and thus breakage and a defective ratio are low. Accordingly, a composite agent containing rosuvastatin effective to relieve and treat a hyperlipemia symptom, or its pharmaceutically acceptable salt can be provided with high efficiency, and is present in a composite formulation form, and thus compliance of a patient can be improved.
    Type: Application
    Filed: April 30, 2014
    Publication date: February 18, 2016
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Yong Il KIM, Hayoung JEONG, Kyeong Soo KIM, Jae Hyun PARK, Jong Soo WOO
  • Publication number: 20160045445
    Abstract: Nanoparticles that include a chemotherapeutic agent and an anti-inflammatory are particularly cytotoxic to prostate cancer cells.
    Type: Application
    Filed: April 9, 2014
    Publication date: February 18, 2016
    Inventors: Shanta Dhar, Rakesh Kumar Pathak
  • Publication number: 20160045446
    Abstract: The present invention provides a novel oral administration preparation that enables administration of silodosin, which is a drug with extremely strong bitterness, without a foreign-body sensation even without water, and has dissolution properties of being able to reproduce an effective blood concentration for the treatment of dysuria associated with benign prostatic hyperplasia or the like. The present invention relates to a masked particle and a novel oral administration preparation comprising the masked particle or the like, wherein the masked particle obtained by granulating or coating a drug particle comprising a fine powder of silodosin with a coating agent comprising a non-enteric polymer, and a content of the non-enteric polymer is 80 parts by mass to 400 parts by mass relative to 100 parts by mass of silodosin.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 18, 2016
    Applicant: KISSEI PHARMACEUTICAL CO., LTD.
    Inventors: Yusuke SHIBATA, Nobuyuki ISSHIKI, Shin-ichiro KIMURA
  • Publication number: 20160045447
    Abstract: The present invention provides a microcapsule pharmaceutical composition of at least a bisquinoline drug. said microcapsule comprises a drug core of a pharmaceutically effective amount of a bisquinoline drug and a polymeric coating over the core. This microcapsule pharmaceutical composition has desirable pharmaceutical properties, including taste masking effect and a high stability.
    Type: Application
    Filed: March 21, 2014
    Publication date: February 18, 2016
    Inventors: Christian STOLLBERG, Giancarla BIANCHI, Flavio FABIANI, Luigi BOLTRI
  • Publication number: 20160045448
    Abstract: A composition is provided that includes a microvesicle derived from an edible plant and a therapeutic agent conjugated to the microvesicle. The therapeutic agent can be chemically-linked to a plasma membrane of the microvesicle with a cross-linking agent and the edible plant can be a fruit or a vegetable. Methods for treating an inflammatory disorder or a cancer are further provided and include administering to a subject in need thereof an effective amount of a composition including a microvesicle derived from an edible plant and having a therapeutic agent conjugated to the microvesicle.
    Type: Application
    Filed: August 13, 2015
    Publication date: February 18, 2016
    Inventor: Huang-Ge Zhang
  • Publication number: 20160045449
    Abstract: The invention relates to compositions and methods for attenuating opioid induced respiratory depression. Such compositions comprise opioids and sequestered opioid antagonists in a multi-particulate dosage formulation.
    Type: Application
    Filed: October 26, 2015
    Publication date: February 18, 2016
    Inventors: Michael J. Lamson, Veeraindar Goli
  • Publication number: 20160045450
    Abstract: The present invention relates generally to a pharmaceutical formulation for use in the treatment and/or prevention of restenosis in a subject in need thereof. Methods of treatment and/or prevention are also provided.
    Type: Application
    Filed: March 27, 2014
    Publication date: February 18, 2016
    Inventors: Florence DELIE, Olivier JORDAN, Ludmila LUCA, François SAUCY, Jacques-Antoine HAEFLIGER, Ioanna MYLONAKI
  • Publication number: 20160045451
    Abstract: Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval.
    Type: Application
    Filed: October 28, 2015
    Publication date: February 18, 2016
    Applicant: AGILE THERAPEUTICS, INC.
    Inventors: Thomas M. ROSSI, Marie FOEGH, Agis KYDONIEUS
  • Publication number: 20160045452
    Abstract: Contained herein are compositions, formulations, methods, and kits for treating regional fat deposits and fat-related conditions. Certain methods comprise administering tetradecyl sulfate, tetradecyl sulfate-like compounds, and pharmaceutically or cosmetically acceptable salts, solvates, prodrugs, or esters thereof and a liquid carrier.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventor: John Daniel DOBAK
  • Publication number: 20160045453
    Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.
    Type: Application
    Filed: September 4, 2015
    Publication date: February 18, 2016
    Inventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
  • Publication number: 20160045454
    Abstract: The invention provides compositions and methods for the prevention, treatment, or management of sexual dysfunction, such as premature ejaculation. The method comprises administering an effective amount of curcuminoid containing composition to a human male on an as-needed basis shortly before sexual activity to delay ejaculation.
    Type: Application
    Filed: August 12, 2015
    Publication date: February 18, 2016
    Inventors: Tianxin Wang, Shazhou Zou