Patents Issued in March 29, 2016
  • Methods for enhancing, improving, or increasing fertility or reproductive function
    Patent number: 9295662
    Abstract: The present disclosure is directed to methods for enhancing, improving or increasing fertility or reproductive function. For example, the present disclosure is directed to a method for enhancing, improving, or increasing a female human's likelihood of becoming pregnant comprising: administering to the human a nutritional, dietary, or food fatty acid supplement comprising: at least 30% docosahexaenoic acid (DHA), by weight of the total fatty acids in the supplement in a form chosen from ethyl ester, free fatty acid, and triglyceride.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: March 29, 2016
    Assignees: Children's Medical Center Corporation, The General Hospital Corporation
    Inventors: Mark Puder, Deepika Nehra, Bo R. Rueda
  • Drug coated balloon with in-situ formed drug containing microspheres
    Patent number: 9295663
    Abstract: The current invention relates to methods of forming a coating that involves the in-situ formation of drug microspheres. The coating may be applied to a medical device, such as a catheter balloon or a stent. Coated devices and methods of treatment therewith are also encompassed within the embodiments of the present invention.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: March 29, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Stephen D. Pacetti, John J. Stankus
  • Methods for lowering blood glucose
    Patent number: 9295664
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: March 29, 2016
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Inhibition of neovascularization by simultaneous inhibition of prostanoid IP and EP4 receptors
    Patent number: 9295665
    Abstract: There are provided inter alia methods and compounds useful for decreasing neovascularization (e.g., choroidal neovascularization) in a subject in need thereof.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: March 29, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Jenny W. Wang, David F. Woodward
  • Bladder cancer treatment and methods
    Patent number: 9295666
    Abstract: Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: March 29, 2016
    Assignee: Spectrum Pharmaceuticals, Inc.
    Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen, Dorla Mirejovsky, Guru Reddy, Luigi Lenaz
  • Pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A inhibitor as an active ingredient
    Patent number: 9295667
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver, and more specifically relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A (cytochrome P450A) inhibitor as an active ingredient. According to the present invention, the CYP4A inhibitor suppresses endoplasmic reticulum stress, reduces the blood insulin concentration and suppresses apoptosis of liver cells, and hence exhibits effects in preventing or treating diabetes or fatty liver.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 29, 2016
    Assignee: Korea Basic Science Institute
    Inventors: Gun-Hwa Kim, Soohyun Kim, Jong-Soon Choi, Seung Il Kim, Edmond Changkyun Park
  • Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases
    Patent number: 9295668
    Abstract: The aromatase inhibitor 4,4?-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile increases testosterone levels and treats hypogonadism and related diseases. A particular dosing regimen is disclosed as well as pharmaceutical compositions comprising said of 4,4?-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, optionally in combination with other active ingredients and kits comprising the pharmaceutical compositions.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: March 29, 2016
    Assignee: Merco BioPharma 2 Limited
    Inventors: Ann Taylor, Lloyd B. Klickstein
  • Combination therapy for proliferative disorders
    Patent number: 9295669
    Abstract: The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: March 29, 2016
    Assignee: Hoffman La-Roche Inc.
    Inventors: Kapil Dhingra, Brian Higgins, Kenneth Kolinsky, Richard J. Lee, Brian Lestini, Kathryn Packman, Fei Su
  • Methods for treating obstructive sleep apnea
    Patent number: 9295670
    Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: March 29, 2016
    Assignee: PFANTASTIC MEDICAL RESEARCH INSTITUTE, LLC
    Inventor: Jian-Qiang Fan
  • Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
    Patent number: 9295671
    Abstract: Chemical entities that are benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: March 29, 2016
    Assignee: NEUPHARMA, INC.
    Inventors: Yong-Liang Zhu, Xiangping Qian
  • Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
    Patent number: 9295672
    Abstract: Provided herein is an optically active pyrazolylaminoquinazoline, and pharmaceutical compositions thereof. Also provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a JAK-mediated condition, disorder, or disease. Further provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a proliferative disease, inflammatory disease, or renal disease.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: March 29, 2016
    Assignee: Ambit Biosciences Corporation
    Inventors: Mark W. Holladay, Eduardo Setti
  • Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
    Patent number: 9295673
    Abstract: The present invention provides for a method for treating a disease condition associated with PI3-kinase ? and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase ? and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: March 29, 2016
    Assignee: Intellikine LLC
    Inventors: Pingda Ren, Yi Liu, Katayoun Jessen, Xin Guo, Christian Rommel, Troy Edward Wilson
  • Metalloporphyrin neurological treatments
    Patent number: 9295674
    Abstract: Methods and compositions for treating a subject suffering from exposure to a chemical threat agent are disclosed.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: March 29, 2016
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventor: Manisha Patel
  • Testosterone gel compositions and related methods
    Patent number: 9295675
    Abstract: Described are gel compositions containing active pharmaceutical ingredient such as testosterone, solvent, and thickener, the gel compositions being useful for transdermal administration of the active ingredient to a patient, and related methods. Certain embodiments of the gel composition specifically exclude Hsieh enhancer.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: March 29, 2016
    Assignee: Upsher-Smith Laboratories, Inc.
    Inventor: Harish K. Pimplaskar
  • Mutation mimicking compounds that bind to the kinase domain of EGFR
    Patent number: 9295676
    Abstract: This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: March 29, 2016
    Assignee: The Trustees Of The University of Pennsylvania
    Inventors: Alan Berezov, Mark I. Greene, Natalie Minkovsky, Zheng Cai, Hongtao Zhang
  • Polyhydroxylated bile acids for treatment of biliary disorders
    Patent number: 9295677
    Abstract: The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis of portal hypertension. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow. New compounds 2?,3?,7?,12?-tetrahydroxy-5?-cholanoic acid and 3?.4?,7?,12?-tetrahydroxy-5?-cholanoic acid are disclosed, uses thereof and synthesis thereof.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: March 29, 2016
    Assignee: Qing Bile Therapeutics Inc.
    Inventors: Victor Ling, Renxue Wang, Jonathan Ahab Sheps
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9295678
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: March 29, 2016
    Assignees: The UAB Research Foundation, The State of Oregon Acting By And Through The State Board Of Higher Education On Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Prodrugs of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
    Patent number: 9295679
    Abstract: Prodrugs of steroidal C-17 benzoazoles, pyrimidinoazoles (az-abenzoazoles) and diazines. Methods of synthesis are also described, whereby a prodrug group is substituted for a functional group at A ring portion of the ABC ring structure of the steroid. Suitable pro-drug groups include amino acid groups, succinate groups, phosphate groups, or sulfamate groups. The prodrugs of the disclosed compounds allow for improved oral bioavailability of the compounds that are inhibitors of human CYP 17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds and the corresponding prodrugs are useful for the treatment of conditions such as human prostate cancer, breast cancer, and prostate hyperplasia.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: March 29, 2016
    Assignee: University of Maryland, Baltimore
    Inventors: Vincent Njar, Angela Brodie, Lalji K. Gediya
  • System and method for diagnosis and treatment
    Patent number: 9295680
    Abstract: This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: March 29, 2016
    Assignee: Pop Test Oncology Limited Liability Company
    Inventors: Randice Lisa Altschul, Neil David Theise, Myron Rapkin, Rebecca O'Brien
  • Multifunctional topical formulation for the treatment of acne vulgaris and other skin conditions
    Patent number: 9295681
    Abstract: A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an ?-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The ?-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: March 29, 2016
    Assignee: Kantian Sciences Corporation
    Inventor: Robert D. Kross
  • Adjuvant immunotherapy for the preventive, curative or palliative treatment of chronic systemic diseases such as cancer, of clinical manifestations associated with diseases like cachexia and correction of adverse effects of drugs such as immunosuppression, neutropenia and lymphopenia, comprising the association or combination of a biological response modifier specially selected and other substances with antineoplastic action and/or other treatments
    Patent number: 9295682
    Abstract: The present invention comprises a new combination or association of pharmacologically active substances and/or non-drug treatments for cancer. According to the present invention, the combination or association of substances and/or non-drug treatments is used to treat cancer, clinical problems associated to cancer and adverse side effects related to substances and/or treatments used to fight this illness. The components of the combination or association of substances, the biological response modifier (proteic aggregate of ammonium and magnesium phospholinoleate-palmitoleate anhydride) and at least one substance and/or treatment with antineoplastic properties can be jointly or simultaneously or consecutively or sequentially administered in an appropriate form, according to their chemical properties, and with the use of the most suitable procedures, and also in the most therapeutically effective dose and use.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: March 29, 2016
    Inventor: Iseu da Silva Nunes
  • Omega-3 phospholipid supplements for improved brain maturity
    Patent number: 9295683
    Abstract: The invention relates to omega-3 phospholipid supplements for use in adolescents, and in particular to use omega-3 phospholipid supplements to improve or support brain maturity age. In preferred embodiments, the omega-3 phospholipid is krill oil.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: March 29, 2016
    Assignee: AKER BIOMARINE ANTARCTIC AS
    Inventors: Kjetil Berge, Lena Burri
  • Cream composition enhancing skin absorption of glucosamine
    Patent number: 9295684
    Abstract: The present invention relates to a cream composition of glucosamine, including at least 10 wt %-15 wt % of glucosamine HCL, a methylsulfonylmethane component, a chondroitin component, and a cream base, wherein the composition promotes penetration of glucosamine from skin of affected area by synergistic interaction between components, in order to enhance absorption of human body.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 29, 2016
    Inventor: Ming-Chen Lee
  • Mixed micelles
    Patent number: 9295685
    Abstract: This disclosure is directed to mixed micelle compositions for administration of e.g., therapeutic agents or imaging agents to a subject.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: March 29, 2016
    Assignees: Omeros Corporation, University of Washington through it's center For Commercialization
    Inventors: Wayne R. Gombotz, Suzie Pun, Christopher Mount, Tae Hee Kim, Benjamin W. Dulken
  • Treatment of cancers with A-8R peptide
    Patent number: 9295686
    Abstract: The present invention provides materials and methods useful to treat various sGC?1-expressing cancers. Materials include peptides which interfere with sGC?1's pro-survival functions, thereby resulting in apoptosis of sGC?1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: March 29, 2016
    Assignee: The University of Toledo
    Inventors: Lirim Shemshedini, Shao-Yong Chen, Changmeng Cai, Chen-Lin Hsieh
  • Pharmaceutical formulations comprising high purity cangrelor and methods for preparing and using the same
    Patent number: 9295687
    Abstract: The present invention relates to high purity cangrelor, pharmaceutical formulations comprising high purity cangrelor as an active ingredient, methods for preparing such compounds and formulations, and methods for using the pharmaceutical formulations in the inhibition of platelet activation and aggregation.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: March 29, 2016
    Assignee: THE MEDICINES COMPANY
    Inventors: Panna Dutta, Adel Rafai Far, Min Ding, Rajeshwar Motheram
  • Methods and compositions for treating neuropathies
    Patent number: 9295688
    Abstract: Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: March 29, 2016
    Assignee: Washington University
    Inventors: Jeffrey Milbrandt, Toshiyuki Araki, Yo Sasaki
  • Formulation and delivery of PLGA microspheres
    Patent number: 9295689
    Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
    Type: Grant
    Filed: May 18, 2013
    Date of Patent: March 29, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Antonin de Fougerolles, Kristy M. Wood, Pedro Valencia
  • Sulphated hyaluronic acid for treating degenerative osteoarthritis
    Patent number: 9295690
    Abstract: This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: March 29, 2016
    Assignee: FIDIA FARMACEUTICI S.p.A.
    Inventors: Lanfranco Callegaro, Davide Renier
  • Method for repairing or replacing damaged tissue
    Patent number: 9295691
    Abstract: A method for repairing or replacing damaged tissue, or for providing post-surgical augmentation, comprising administering a pliable biocompatible material and a physiologically acceptable suspending agent to a patient is disclosed. Copolymers of unsubstituted acrylate and substituted acrylate are disclosed as pliable biocompatible materials.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: March 29, 2016
    Inventor: Ayman Boutros
  • Gel-based compositions and methods of use
    Patent number: 9295692
    Abstract: Provided herein are a biocompatible gels, such as an oral gel composition and a topical gel composition. Generally, the oral gel composition may comprise a formulation in ozonized water of a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and glycerol to polymerize the polyacrylate. Optionally, the oral gel composition may comprise a sweetener and/or a flavoring agent. The topical gel composition is a similar formulation in ozonized water with a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and hydrogen peroxide to polymerize the polyacrylate. Further provided are methods of using the gel compositions to reduce dental caries and to treat a skin injury.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: March 29, 2016
    Inventor: Arcadio Maldonado Rodriguez
  • Bi-functional co-polymer use for ophthalmic and other topical and local applications
    Patent number: 9295693
    Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: March 29, 2016
    Assignee: Eyeon Particle Sciences LLC
    Inventors: Eugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark Mitchnick
  • Composition comprising silver nanoparticles and extracts of Polygonum Multiforum Thunb and the use thereof
    Patent number: 9295694
    Abstract: The present invention relates to a pharmaceutical composition comprising an effective amount of silver nanoparticles and extracts of Polygonum Multiflorum Thunb, a method for increasing hair growth by administering the pharmaceutical composition locally to a host, and use thereof.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: March 29, 2016
    Assignee: Skylight Technology Limited
    Inventor: Mingfen Tsai
  • Temperature-insensitive calcium phosphate cements
    Patent number: 9295695
    Abstract: Temperature-insensitive calcium phosphate cements and methods of using the same are provided. Aspects of the cements include a dry component having fine and coarse calcium phosphate particulate reactants and a setting fluid which includes a cellulose. The dry component and setting fluid may be combined over a broad temperature range to produce a flowable composition. The resultant flowable composition finds use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: March 29, 2016
    Assignee: Skeletal Kinetics, LLC
    Inventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
  • Compositions and methods for restoring or rejuvenating stem/progenitor cell function
    Patent number: 9295696
    Abstract: This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or improves health of the mammal. In addition, the invention also relates to compositions containing one or more regulatory factors secreted or released from isolated mammalian stem/progenitor cells and use of such compositions to extend lifespan and/or improve health of a mammal. Also provided are methods of treating, delaying, preventing or reversing progeria or related syndromes in a mammal using isolated autologous or allogeneic stem/progenitor cells and/or regulatory factors secreted or released therefrom.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 29, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Laura J. Niedernhofer, Mitra Lavasani, Paul D. Robbins, Johnny Huard
  • Episomal reprogramming with chemicals
    Patent number: 9295697
    Abstract: Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: March 29, 2016
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Junying Yu
  • Krill oil and carotenoid composition, associated method and delivery system
    Patent number: 9295698
    Abstract: A medicine delivery system includes an inner capsule containing carotenoids and an outer capsule in which the inner capsule is contained within the outer capsule and the outer capsule containing a therapeutically effective amount of krill oil. In one example, the carotenoids comprise at least S, S?-astaxanthin derived from Haematococcus pluvialis, and one or more of lutein and/or trans-zeaxanthin or meso-zeaxanthin. The medicine delivery system also includes 0.5 to 8 mg of astaxanthin, 2 to 15 mg of lutein and 0.2 to 12 mg of trans-zeaxanthin contained within the inner capsule. In a specific example, the medicine delivery system includes about 4 mg of astaxanthin, about 10 mg of lutein and about 1.2 mg of trans-zeaxanthin contained within the inner capsule.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: March 29, 2016
    Assignee: U.S. NUTRACEUTICALS, LLC
    Inventors: John A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Krill oil and carotenoid composition, associated method and delivery system
    Patent number: 9295699
    Abstract: A medicine delivery system includes an inner capsule containing carotenoids and an outer capsule in which the inner capsule is contained within the outer capsule and the outer capsule containing a therapeutically effective amount of krill oil. In one example, the carotenoids comprise at least S,S?-astaxanthin derived from Haematococcus pluvialis, and one or more of lutein and/or trans-zeaxanthin or meso-zeaxanthin. The medicine delivery system also includes 0.5 to 8 mg of astaxanthin, 2 to 15 mg of lutein and 0.2 to 12 mg of trans-zeaxanthin contained within the inner capsule. In a specific example, the medicine delivery system includes about 4 mg of astaxanthin, about 10 mg of lutein and about 1.2 mg of trans-zeaxanthin contained within the inner capsule.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: March 29, 2016
    Assignee: U.S. NUTRACEUTICALS, LLC
    Inventors: John A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Wound healing composition
    Patent number: 9295700
    Abstract: The wound healing composition is a composition for topical application in or on a wound that is believed to promote hemostasis and tissue growth. The wound healing composition includes a mixture of Dracaena cinnabari (dragon's blood), propolis (bee's glue) extract powder, and honey, preferably seder honey. An exemplary wound healing composition includes about 25 gm seder honey, 1.5 gm of 70% propolis extract powder, and about 1 gm D. cinnabari powder. The powders are mixed into the viscous honey base, and the composition may be applied directly to the wound. Alternatively, the composition may be applied to sterile gauze, and the wound, particularly an open surgical wound, may be packed with the gauze, or the gauze may be applied as a wound dressing.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: March 29, 2016
    Inventor: Abdulmohsen Ebrahim Al-Terki
  • strains for the production of bioactive peptides having anti-hypertensive and cholesterol-lowering effects
    Patent number: 9295701
    Abstract: New Lactococcus lactis strains, NRRL B-50571 and NRRL B-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower LDL-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: March 29, 2016
    Assignees: CENTRO DE INVESTIGACION EN ALIMENTACION Y DESARROLLO, A.C. (CIAD)
    Inventors: Belinda Vallejo Galland, Aarón Fernando González Córdova, Jóse Carlos Rodríguez Figueroa
  • Process for producing poxviruses and poxvirus compositions
    Patent number: 9295702
    Abstract: The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a process for producing poxviruses and poxviruses obtained thereof. Moreover, the present invention also relates to the use of said poxvirus and said composition for the preparation of a medicament.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: March 29, 2016
    Assignee: Transgene S.A.
    Inventors: Daniel Malarme, Yves Cordier, Claude Sene
  • Compositions and methods using pomegranate extracts
    Patent number: 9295703
    Abstract: Methods of using pomegranate extracts of the present invention for treating patients with atherosclerosis, or increased intima-media thickness of an artery, are provided. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. The methods of the present invention may also be used to decrease the incidence of stroke or heart attack in a patient.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: March 29, 2016
    Assignee: POM Wonderful, LLC
    Inventors: Michael Aviram, Leslie Dornfeld
  • Composition for preventing or treating atopic dermatitis including galenical extract or lactobacillus fermentation thereof
    Patent number: 9295704
    Abstract: The present invention relates to a pharmaceutical composition and health supplement for preventing or treating atopic dermatitis, the composition and supplement having as active ingredients extract of a galenical mixture including sophora root, licorice, lonicer aflower, Korean angelica root, Korean aralia root, saussurea root, seselos radix, zizyphus spinosi, Houttuynia cordata, forsythia fruit, lappa fruit, Epimedium koreanum Nakai, ginseng, lithospermum, oleoresin, cnidium, scorophulariae radix, and reynoutria, or lactobacillus fermentation of the galenical extract prepared by inoculating lactobacillus to the galenical extract and fermenting same.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: March 29, 2016
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Jin Yeul Ma, Tae Ho Chung, Ga Young Im, Dong Seon Kim, Young Ran Um, Hyun Ae Eum, Jae Hoon Lee, Sung Up Choi, Byoung Heon Cho
  • Treatment for nephritis
    Patent number: 9295705
    Abstract: This invention relates to methods for treatment of nephritis. This invention further provides a method of treating with nephritis comprising administering to the subject an amount of herbal pharmaceutical composition thereof effective to treat the subject. Move particularly, this invention provides an herbal pharmaceutical composition comprising Rhizoma Atractylodis macrocephalae, Eucommiae cortex, Lonicerae caulis, and Hedyotidis diffusae Herba thereof for use in treating a subject afflicted with active nephritis.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: March 29, 2016
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Ann Chen, Shuk-Man Ka, Rey-Yuh Wu, Jia-Ming Chang
  • Phytotherapic pharmaceutical combination of and , phytotherapic pharmaceutical composition, process for preparing a phytotherapic pharmaceutical composition and veterinary uses thereof
    Patent number: 9295706
    Abstract: Phytotherapic pharmaceutical forms with antimicrobial activity, comprising a mixture of essential oils of Lippia salvifolia and Lippia sidoides, appropriate for the treatment of mastitis, notably bovine mastitis, and to a process of preparation of said compositions and their veterinary uses.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: March 29, 2016
    Inventors: Ana Maria Soares Pereira, Suzelei de Castro Franca, Ana Lucia Fachin, Bianca Waleria Bertoni, Edieidia Souza Pina, Juliana da Silva Coppede
  • Neuroprotective and neurorestorative methods and compositions
    Patent number: 9295707
    Abstract: The invention relates to methods and products for preventing and treating neuronal cell death-associated diseases and/or conditions. The products and methods are useful for research and for clinical applications relating to neuronal cell-death associated diseases and/or conditions.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: March 29, 2016
    Inventor: Angela Shashoua
  • Modified release formulations for oprozomib
    Patent number: 9295708
    Abstract: This disclosure features modified release pharmaceutical formulations (e.g., extended release pharmaceutical formulations; e.g., solid dosage forms, e.g., tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the formulations.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: March 29, 2016
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Mouhannad Jumaa, Tony Muchamuel, Naveen Bejugam, Hansen Wong, Christopher J. Kirk, Rahul Vishram Manek, Sanjeev Sharma
  • Pharmaceutical composition comprising MicroRNA-30B, MicroRNA-133A, or MicroRNA-202-5P inhibitor for inhibiting cancer
    Patent number: 9295709
    Abstract: Provided is an anticancer composition, and particularly, a pharmaceutical composition for inhibiting cancer, which includes a microRNA-30b, microRNA-133a, or microRNA-202-5p inhibitor as an active ingredient. The pharmaceutical composition may suppress microRNA-30b, microRNA-133a, or microRNA-202-5p, thereby inhibiting proliferation of cancer cells, and eventually, is expected to be useful for cancer treatment.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 29, 2016
    Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
    Inventors: You-Mie Lee, Su Young Oh
  • Treatment and diagnosis of inflammatory disorders and HIV
    Patent number: 9295710
    Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: March 29, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Scott Kachlany
  • Cosmetic and therapeutic use of proteins of DJ-1 type for treating skin dryness
    Patent number: 9295711
    Abstract: The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: March 29, 2016
    Assignee: L'OREAL
    Inventors: Dominique Bernard, Lucie Simonetti, Isabelle Castiel