Abstract: Monoclonal antibodies against LRP6 and that block the Wnt signaling pathway are disclosed. Methods of production and use thereof are also disclosed.

Abstract: The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described.

Abstract: The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

Abstract: A method of treating a pathological syndrome includes administration of an activated form of ultra-low doses of antibodies to an antigen, wherein said activated form is obtained by repeated consecutive dilution combined with external impact, and the antigen is a substance or a pharmaceutical agent exerting influence upon the mechanisms of formation of this particular pathological syndrome.

Abstract: The present application relates to a method of treating disorders of the cardiovascular system which includes administration of homeopathically potentized form of at least one antibody to an antigen, wherein the homeopathically potentized form is obtained by repeated consecutive dilution combined with external impact, and the antigen is a substance or a pharmaceutical agent capable of regulating cardiovascular disorders and pharmaceutical agents thereof.

Abstract: The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+) amphetamine, or (+) MDMA.

Abstract: The present invention relates to a new method for preparing microcrystalline cellulose, comprising a prior step of compaction of the cellulose before degradation of the glucose chains and obtaining the suitable degree of polymerization. It is also described that the method of the invention allows a considerable reduction in the consumption of energy, water and possible chemicals which are used for reducing the degree of polymerization. The microcrystalline cellulose obtained can be used as a pharmaceutical excipient in tablets, and presents disintegration features comparable to those of the microcrystalline cellulose obtained by a spraying process.

Abstract: Process for the transition between an ethylene co-polymerization process in a polymerization reactor in the presence of a catalyst and of ethylene E and an olefin co-monomer A to produce an ethylene copolymer PEA into an ethylene co-polymerization process carried out in the same polymerization reactor in the presence of a catalyst and of ethylene E and an olefin co-monomer B to produce an ethylene copolymer PEB. Co-monomers A and B are different and are both present in the reactor during at least part of the transition from PEA to PEB. The transition is performed continuously by (i) starting the transition by stopping steady state production of ethylene copolymer PEA and (ii) ending the transition when steady state production of ethylene copolymer PEB is achieved.

Abstract: The present invention relates to a process of preparing a polyolefin in a loop reactor by introducing anti-fouling agent in by-pass pipes. Also, the invention relates to the use of anti-fouling agent to prevent blockage by feeding the anti-fouling agent into the by-pass pipes of the loop reactor.

Abstract: A process for the preparation of an elastomer capable of swelling in oil and/or in water and brine comprising the steps of: a) making an aqueous inverse emulsion of particles of a polymer comprising a betaine group prepared by inverse emulsion polymerization of monomers Ab comprising a betaine group, optionally other monomers Ba and a small quantity of polyvalent, preferably divalent or trivalent monomers Ca, comprised in an aqueous phase dispersed in the form of droplets in a hydrophobic external phase having hydrophobic surfactants, the molar ratio of the monomers Ab to the optional monomers Ba being between 4/96 and 40/60, preferably 7/93 and 30/70, the molar ratio of the polyvalent, preferably divalent or trivalent monomers Ca per mole of polymer being between 1.5 and 10, preferably between 2 and 4, and b) compounding said elastomer with the aqueous inverse emulsion obtained by step a).

Abstract: Ink jet printing on a non-absorbent substrate involves a wet primer having a primer viscosity. The wet primer is applied on the non-absorbent substrate. An ink jet ink having an ink jet viscosity lower than the primer viscosity is jetted over the wet primer while the primer is still wet. The wet primer and ink are simultaneously cured on the substrate.

Abstract: The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.

Abstract: Methods for controlling properties of an olefin polymer using an alcohol compound are disclosed. The MI and the HLMI of the polymer can be decreased, and the Mw and the Mz of the polymer can be increased, via the addition of the alcohol compound.

Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilizing two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products even in presence of air or of acids.

Abstract: The present invention relates to a method for producing a high-molecular-weight copolymer of polar group-containing allyl monomers comprising monomer units represented by formulae (3) and (4) (in the formulae, R1 represents a hydrogen atom (H) or hydrocarbon group having 1 to 6 carbon atoms; R2 represents —OH, —OCOR3 (R3 represents hydrocarbon group having 1 to 5 carbon atoms), —N(R4)2 (R4 represents a hydrogen atom or hydrocarbon group having 1 to 5 carbon atoms); and n and m are a value representing the molar ratio of each of the monomer units), which has few branches and unsaturated group at the molecular end, by copolymerizing olefin and an allyl compound using a metal complex of group 10 elements in the periodic system represented by formula (I) as a catalyst.

Abstract: The invention relates to polyvinyl acetals obtainable by reacting polyvinyl alcohol with at least one aldehyde with a degree of acetalization of at least 75 mol %, characterized by an OH blockiness of the polyvinyl acetal, defined as a quotient from the number of methylene groups of two adjacent alcohol sequences (VV) and the sum of the number of methylene groups of adjacent alcohol/acetal sequences and acetal/acetal sequences (VB+BB), of more than 0.151, as well as a process for the preparation thereof.

Abstract: Embodiments disclosed herein generally relate to olefin polymerization catalysts, and more specifically to chromium-based catalysts and methods of use of chromium-based catalysts for the production of polyolefins, and even more specifically to methods for controlling or tailoring the flow index response of chromium-based catalysts through the controlled addition of a reducing agent to the catalysts under controlled mixing conditions.

Abstract: A process for photopolymerizing a photopolymerizable compound having at least one ethylenically unsaturated double bond, comprises contacting said photopolymerizable compound with a photoactive oxide and irradiating it, wherein the photoactive oxide includes one or more moieties together with a moiety wherein there are at least 2 atoms between moiety I and moiety II in the additive and where X represents an oxygen or sulphur atom. Novel compounds which exhibit beneficial effects on cure in the presence of oxygen, which may be especially advantageous when LEDs are used, are also described.

Abstract: The present invention relates to a process for the preparation of sevelamer, in particular sevelamer hydrochloride and sevelamer carbonate/bicarbonate, by means of a process that allows sevelamer to be obtained with good yields and using conventional reactors, without requiring to use specific and expensive equipment.

Abstract: Methods for preparing metallocene-based catalyst systems containing an activator-support are disclosed. These methods can include contacting a solid metallocene compound, an activator-support, and an organoaluminum compound, resulting in catalyst systems with increased catalytic activity as compared to catalyst systems utilizing a solution of the metallocene compound.

Abstract: An ethylene-based polymer, which is a low density polyethylene (LDPE), obtained by free radical polymerization of ethylene, and wherein the LDPE has a GPC parameter “LSP” less than 1.60. An ethylene-based polymer that comprises the following features: a) at least 0.1 amyl groups per 1000 total carbon atoms; b) a melt index of 0.01 to 0.3; c) a z-average molecular weight of Mz (conv.) of greater than 350,000 g/mol and less than 425,000 g/mol; d) a gpcBR value from 1.50 to 2.05, and e) a MWD(conv) [Mw(conv)/Mn(conv)] from 6 to 9. An ethylene-based polymer that comprises the following features: a) at least 0.1 amyl groups per 1000 total carbon atoms; b) a melt viscosity ratio (V0.1/V100), at 190° C., greater than, or equal to, 58; c) a melt viscosity at 0.1 rad/s, 190° C., greater than, or equal to, 40,000 Pa·s, and d) a gpcBR value from 1.50 to 2.25.

Abstract: The present invention relates to a propylene-butene-1 random copolymer which has a butene-1 content of 1-6 mol % and a relative dispersity of butene-1, as determined according to NMR method, of greater than 98.5%. The propylene-butene-1 random copolymer of the present invention has a high relative dispersity of butene-1, as well as better transparency and heat resistance, so that it is more suitable for packaging food that may be edible after heating. Moreover, the copolymer has a lower xylene solubles content at room temperature. In addition, the present invention further relates to a method for preparing the copolymer and to a composition and an article comprising the copolymer.

Abstract: Disclosed herein are catalyst compositions containing boron-bridged, cyclopentadienyl-fluorenyl metallocene compounds with an alkenyl substituent. These catalyst compositions can be used for the polymerization of olefins. For example, ethylene copolymers produced using these catalyst compositions can be characterized by a combination of a flat or a conventional comonomer distribution and low levels of long chain branching.

Abstract: Disclosed herein are catalyst compositions containing boron bridged, bis-indenyl metallocene compounds with an alkenyl substituent. These catalyst compositions can be used for the polymerization of olefins. For example, ethylene copolymers produced using these catalyst compositions can be characterized by a density less than 0.92 g/cm3 and a melt index greater than 25 g/10 min.

Abstract: The present invention relates to a thickeners that are the polymerization product of a monomer mixture comprising: (a) at least one C3 to C30 olefin; (b) at least one monomer that contains at least one carboxylic acid group; (c) at least one ethylenically unsaturated ester monomer; and (d) one or more crosslinking compounds. Optionally, the above multi-purpose polymer compositions can further include any combination of one or more of: (e) at least one functional monomer; (f) at least one associative hydrophobic monomer; and/or (g) at least one chain transfer agent (CTA) and/or at least one polymeric stabilizer. The thickeners of the present invention are useful in a variety of products including, but not limited to, personal care products, health care products, household care products, institutional and industrial care products, and industrial applications.

Abstract: Disclosed are a propylene resin material capable of affording a molded article superior in impact properties, tensile properties, and appearance, and a method for producing the same. The propylene resin material includes a propylene homopolymer portion and a propylene-ethylene copolymer portion and satisfies specific requirements. The production method includes the step of mixing an organic peroxide with a propylene polymeric material produced via a multistage polymerization process using a polymerization catalyst and comprising a propylene homopolymer portion and a propylene-ethylene copolymer portion, the step of heating the mixture obtained via the mixing step, at a temperature lower than a decomposition temperature of the organic peroxide at which the half-life of the organic peroxide is one minute, and the step of washing the mixture heated in the heating step, with a medium containing an organic solvent.

Abstract: Lignocellulosic composites are made by pressing a mixture of a particulate lignocellulosic material with polymeric MDI, in the presence of a fatty amine ethoxylate anti-masking agent.

Abstract: The present invention discloses one liquid type cyanate ester-epoxy composite resin composition comprised of (A) cyanate ester resin, (B) epoxy resin and (C) latent curing agent. The present one liquid type cyanate ester-epoxy composite resin composition is characterized in that the above (C) latent curing agent is comprised of a modified amine (a), which has one or more amino group having active hydrogen within a molecule, obtained by a reaction of a polyamine compound (a-1) with an epoxy compound (a-2), and a phenol resin (b), and that the above polyamine compound (a-1) is a polyether polyamine compound and/or the above epoxy compound (a-2) is a polyether polyepoxy compound.

Abstract: A thermosetting epoxy resin composition comprising (A) a reaction mixture of a triazine derivative epoxy resin and an acid anhydride at a ratio of the epoxy group equivalent to the acid anhydride equivalent of 0.6 to 2.0; (B) an internal mold release agent; (C) a reflective material; (D) an inorganic filler; and (E) a curing catalyst. The internal mold release agent of component (B) comprises a carboxylate ester represented by: R11—COO—R12??(1) wherein R11 and R12 are CnH2n+1 and n is 1 to 30 and a compound represented by: wherein R1, R2, and R3 are selected from H, —OH, —OR, and —OCOCaHb with the proviso that at least one includes —OCOCaHb; R is CnH2n+1 (wherein n is an integer of 1 to 30), a is 10 to 30, and b is 17 to 61.

Abstract: An epoxy resin curing agent which provides good adhesiveness to polyester in addition to excellent performance and high gas-barrier properties of epoxy resins, an epoxy resin composition containing the epoxy resin curing agent, an adhesive for laminating which mainly contains the composition, a laminate film obtained by using the adhesive, a multi-layer packaging material, and a packaging bag. The epoxy resin curing agent is a reaction product of (A) m-xylylenediamine or p-xylylenediamine, (B) a polyfunctional compound having one acyl group, which forms amide linkage by a reaction with polyamine and is capable of forming an oligomer; and (C) an aromatic dicarboxylic acid, an ester thereof, an amide thereof, an acid anhydride thereof, or an acid chloride thereof.

Abstract: A series of ladder-type multifused arenes (hexacyclic, heptacyclic and nonacyclic units) and the synthesizing methods thereof are provided. The ladder-type multifused arenes are copolymerized with various electron-deficient acceptor units to afford various p-type low-band gap conjugated copolymers.

Abstract: A method of preparing a poly(glycolic acid) (PGA) from the C1 feedstocks carbon monoxide and formaldehyde or its equivalent. By controlling the comonomer feed ratios and the polymerization temperatures, high quality PGA can be prepared. The method is extended to copolymers of PGA where alkylene oxides or cyclic ether comonomers are included into the polymerization mixture with the C1 monomers to yield polyester-ether thermoplastics.

Abstract: A current breaker case including a polycarbonate resin composition that includes a polycarbonate-polyorganosiloxane copolymer and has a viscosity-average molecular weight of 18000 to 25000.

Abstract: Processes for increasing the chemical resistance of a surface of a formed article are disclosed. The formed article is produced from a polymeric composition comprising a photoactive additive containing photoactive groups derived from a monofunctional benzophenone. The surface of the formed article is then exposed to ultraviolet light to cause crosslinking of the photoactive additive and produce a crosslinked surface. The crosslinking enhances the chemical resistance of the surface. Various means for controlling the depth of the crosslinking are also discussed.

Abstract: Disclosed are a terminally modified polyoxyalkylene glycol which may dramatically improve color uniformity and machinability, when applied to a polycarbonate resin transmittance, a polycarbonate resin composition comprising the same, and a light guide plate manufactured using the same.

Abstract: Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.

Abstract: Provided is an energy ray-curable elastomer composition which can increase the inter-crosslinking point molecular weight without changing the kind of an energy ray-curable compound before cured and which provides an oligomer-cured substance having a braking elongation compatible with a processability, to be specific, an energy ray-curable elastomer composition containing (A) an energy ray-curable compound having a (meth)acryloyl group and (B) a polythiol compound having 2 to 6 mercapto groups in a molecule, wherein a functional group number ratio of the (meth)acryloyl group in the above composition to the mercapto group in the component (B) is 100:0.1 to 100:5n (n is the number of the mercapto group in a molecule of the polythiol compound).

Abstract: It is to provide a solution for forming an organic metal thin film that can form rapidly a dense monomolecular film with less impurity. A solution for forming an organic thin film comprising (A) at least one organic metal compound shown by the following formula (I) (provided that at least one organic metal compound contains a hydroxyl group); and (B) at least one organic metal compound shown by the following formula (II), R3mM2X54-m??(II) wherein the solution is 40?[(A)/{(A)+(B)}]×100?100 (mass %), and 0?[(B)/{(A)+(B)}]×100?60 (mass %); or a solution for forming an organic thin film comprising an organic metal compound having at least one hydroxyl group and at least one hydrolysable group among the organic metal compounds shown by the following formula (I); or a solution for forming an organic thin film wherein the mass ratio of trimer with respect to dimer is greater than 0.5 among the metal organic compound shown by formula (I).

Abstract: Particles having an average diameter of at least 30 nanometers include a polymerization product of a silanol, a cyclic silazane, and an isocyanate. The particles are formed in an oil-in-water emulsion which includes less than 0.1 weight percent of a hydrophobic costabilizer. The particles are formed by a method including the step of reacting the silanol and the cyclic silazane and the isocyanate and the step of forming the oil-in-water emulsion.

Abstract: A hyperbranched polymer based on one or more repeating units of an ABx type monomer, wherein A and B are functional groups and x is greater than or equal to 2, wherein A reacts with, or substantially reacts with, B, wherein B is fractionally functionlized with a plurality of functional groups comprising a first functional group comprising a C6-C30 alkyl chain attached to the repeating unit through a carbonyl group (C?O) via an ester linkage, a second functional group comprising a partially fluorinated or perfluorinated C3-C20 alkyl chain attached to the repeating unit through a carbonyl group (C?O) via an ester linkage, and a third functional group comprising substantially one of a stabilized radical source attached to the repeating unit via a C0-C6 tether, or a 5 to 8 member chloroamide heterocycle of carbon and nitrogen that is attached to the repeating unit via a C2-C6 tether.

Abstract: The present invention is directed to a method to extract lignin from lignocellulosic biomass using lactic acid.

Abstract: A method for granulating a particle-containing material from an industrial process includes mixing the particle-containing material in the presence of water with a material that consists of or comprises a water-absorbing and swellable organic polymer compound which is insoluble in water so as to obtain granulates.

Abstract: The invention provides a method for the manufacture of a gel, said method comprising the steps of: providing a matrix composition comprising a polymeric photoinitiator of the general formula (I): Polymer-[CR2—CHR-Spacer(PI)n]m (I) curing the matrix composition by exposing it to UV radiation and exposing the matrix composition to a swelling medium. The invention also relates to gels obtainable via the above method. The invention provides a hydrophilic gel precursor manufactured from the polymeric photoinitiator of Formula (I). Medical devices comprising the gels and hydrophilic gel precursors of the invention are provided. The invention also provides the use of a polymeric photoinitiator in the manufacture of a gel.

Abstract: Provided are a nanocomposite including a layered inorganic material and a random copolymer containing a hydrophobic monomer and a hydrophilic monomer, a polymer composition including the nanocomposite, and a method for preparing the polymer composition. The random copolymer can be prepared at a low cost in a simple process and function as a compatibilizer in small amounts to maintain excellent properties of the nanocomposite including excellent mechanical characteristics such as abrasion resistance, hardness, tensile modulus and tear resistance, excellent thermal characteristics, high liquid and gas permeability, and low flammability.

Abstract: The invention is directed at new process and systems for preparing composite materials that include a polymer phase and a fiber phase.

Abstract: A transparent exterior window film composite comprising a base sheet material having an outer PET (polyethylene terephthalate) film layer which has been surface treated to elevate adhesion thereto and which is impregnated with an ultra violet light absorber (UVA), the treated surface being coated with a UV stabilized acrylic polymer or co-polymer undercoat having a UV stabilized hard coat layer thereon formed from at least one aliphatic urethane acrylate oligomer and at least one multifunctional acrylate monomer, the undercoat layer having a thickness which is at least as thick as the hard coat.

Abstract: Disclosed is a hydrophilic porous membrane comprising a block copolymer of the formula: A-B-A (I) or A-B (II), wherein block A is (i) a copolymer of glycidol and allyl glycidyl ether, the copolymer having one or more allyl groups; or (ii) a copolymer of glycidol and allyl glycidyl ether, wherein one or more of the allyl groups of the copolymer have been replaced with 1,2-dihydroxypropyl group or a group of the formula: —(CH2)a—S—(CH2)b—X, wherein a, b, and X are as defined herein, and block B is an aromatic hydrophobic polymeric segment, for example, polyethersulfone. Also disclosure is a method of preparing such porous membranes.

Abstract: A method for recycling rubber tires includes mixing the rubber tires and a hydrophobic ionic liquid in a vessel. The hydrophobic ionic liquid is heated to an elevated vapor temperature to produce dissolved components from the rubber tires. A precipitate is produced from at least some of the dissolved components.

Abstract: An aqueous ink for indirect printing applications including water; a co-solvent; a colorant; and a polymer latex comprising an aqueous dispersion of polymer particles wherein the polymer latex has a softening temperature of from about 60° C. to less than 105° C. and a glass transition temperature of from about 45° C. to about 100 C.

Abstract: The present disclosure is directed to a method of increasing optical density by incorporating carbon black in to a colored polyimide composition to obtain a colored polyimide film. The colored polyimide film has 48 to 94 weight percent of a polyimide, 5 to 25 weight percent pigment and 0.05 to 2 weight percent carbon black.