Abstract: This document provides methods and materials for quantifying ocular counter roll and detecting vestibular otolith damage. For example, devices for quantifying ocular counter roll, methods of making devices for quantifying ocular counter roll, and methods for using a device to quantify (e.g., quantify indirectly) ocular counter roll are provided.

Abstract: A retinoscopic device, technique and scale for estimating the reflectance of the macula pigment optical density (MPOD) in normal and abnormal eyes in order to detect early pathology of the retinal pigment epithelium and photoreceptors thus screening for macular pathology the most prevalent of which is Age-related Macular Degeneration (AMD) and retinal edema and cystoid macular edema post cataract surgery.

Abstract: An ophthalmologic imaging apparatus that captures an image of a subject's eye is provided. The apparatus includes a focusing unit configured to focus light returned from the subject's eye that is illuminated by the light of a first wavelength, onto an imaging unit, and a moving unit configured to move the focusing unit based on an optical path length difference between the light of the first wavelength and the light of a second wavelength that is different from the first wavelength when light returned from the subject's eye that is illuminated by the light of the second wavelength is focused onto the imaging unit.

Abstract: Segmentation is provided in multi-modal reconstruction of functional information. Rather than using HU values for segmentation, the HU values are converted into linear attenuation coefficients, such as in a ?-map (Mu map). The conversion uses different functions for different ranges of the HU values. Linear attenuation coefficients are less likely subject to variation by patient, protocol, or scanner. The resulting segmentation may be more consistent across various clinical settings, providing for more accurate multi-modal reconstruction.

Abstract: A hybrid operating room with support structure. The hybrid operating room includes an interior for use in the imaging of and performance of surgery on a patient, the interior including a ceiling. The hybrid operating room also includes a support assembly positioned above the unit for supporting equipment used in conjunction with such imaging and surgery so that the equipment extends downwardly from the ceiling into the interior. The support assembly is designed to support a load of at least 3,500 pounds, and more in certain implementations.

Abstract: Provided is a fluoroscopy apparatus including a fluorescence-image generating portion that generates a fluorescence image; an identifying portion that identifies a position of a high-luminance region in the fluorescence image; a storage portion that stores the position of the high-luminance region; a detecting portion that detects an amount of change in a physical quantity, which can possibly act as a cause of changes in a property of the high-luminance region, starting from a time at which the position of the high-luminance region is identified by the identifying portion; a confidence-level calculating portion that calculates a confidence level of the property of the high-luminance region based on the detected amount of change; and a display-image generating portion that generates a display image in which the display mode at the position of the high-luminance region is set in accordance with the confidence level.

Abstract: An absentminded state determination apparatus includes: a data obtaining element for obtaining a time series data of a physiological characteristic value of a participant, wherein a fluctuation component is overlapped on the time series data, and depends on a state of the participant including normal and absentminded states; a detection element for detecting reflecting portions of the time series data, which reflect on the fluctuation component; a counting element for counting the number of the reflecting portions of the time series data in a determination time period between a determination time and a certain past time; and a determination element for determining according to the number of the reflecting portions at the determination time whether the participant is in the absentminded state. The determination time period has a predetermined time width from the certain past time to the determination time.

Abstract: Systems and methods for prediction and detection of circulatory shock using estimates or measurements of arterial blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance, cardiac ejection fraction, cardiac contractility and ventricular end-diastolic volume are provided. These estimates and measurements are used to determine a type of circulatory shock. In some embodiments, the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock.

Abstract: Every pulse wave, a constant volume control unit performs servo control while updating a servo gain such that a difference between an arterial volume shown by an arterial volume signal that is detected by an arterial volume detection circuit and a control target value of the servo control is less than a control deviation at which a rate of change of the arterial volume relative to a change in cuff pressure is deemed to be constant. Because the control deviation is the difference between the arterial volume shown by the arterial volume signal and the control target value, a blood pressure decision unit decides, as a blood pressure, the cuff pressure sequentially detected in a period during which servo control is performed, by correcting the cuff pressure using the control deviation and the rate of change deemed to be constant.

Abstract: Techniques are provided for use by an implantable medical device or diagnostic sensor for detecting and discriminating euvolemia, hypervolemia and hypovolemia. In one example, the device detects a pressure signal within the patient representative of changes in cardiac pressure overall several cardiac cycles. The device generates separate time-domain and frequency-domain representations of the pressure signal and then discriminates among euvolemia, hypervolemia and hypovolemia within the patient based on an analysis of the time-domain and the frequency-domain representations of the signal. Depending upon the capabilities of the device, suitable warnings may be generated to alert the patient or caregiver. Diuretics or other medications can be titrated to address abnormal fluid conditions such as a fluid overload during hypervolemia. Techniques for detecting a pressure alternans pattern indicative of imminent decompensation are also described.

Abstract: A coaxial dual lumen pigtail catheter utilizes coaxial construction incorporating a thin wall guiding catheter technology for the outer lumen and using a strong braided diagnostic technology for the central lumen to accommodate high-pressure injections. The catheter includes a manifold body to provide for connection to each of the dual lumens. The distal end of the coaxial dual lumen pigtail catheter tapers to a more flexible portion that is perforated by spiral side holes to provide for more undistorted pressure readings in the left ventricle. The coaxial dual lumen pigtail catheter also utilizes proximal straight sideholes at the end of the dual lumen portion and a taper between the dual lumen portion and the single lumen portion.

Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart are identified as the source of the heart rhythm disorder. If the first region has repeating activation and controls the second region for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

Abstract: Systems, devices, and methods for obtaining fractional flow reserve in the presence of a catheter. In a method of determining a fractional flow reserve in the presence of a catheter, the method comprises the steps of obtaining measurements of an inner luminal organ diameter proximal to, at, and distal to a stenosis and a length of the stenosis, obtaining a pressure drop measurement at the stenosis, calculating a volumetric flow of fluid through the inner luminal organ at the stenosis, and determining a stenotic pressure drop at the stenosis corresponding to dimensions of the guidewire as a function of the calculated volumetric flow of fluid through the inner luminal organ at the stenosis, wherein the stenotic pressure drop is indicative of a fractional flow reserve at or near the stenosis.

Abstract: A method determines cardiac output or stroke volume by receiving signal data representing multiple parameters of a patient concurrently acquired over a particular time period and comprising at least one of, (a) a parameter derived from an ECG waveform of the patient, (b) a parameter derived from a blood pressure signal of the patient, (c) a parameter derived from signal data representing oxygen content of blood of the patient and (d) a parameter derived from a patient cardiac impedance value. A selected parameter of the multiple concurrently acquired parameters is used in calculating a heart stroke volume of the patient comprising volume of blood transferred through the blood vessel in a heart cycle, in response to, a combination of a weighted summation of values of the selected parameter over the particular time period. Data representing the calculated heart stroke volume is provided to a destination device.

Abstract: In one embodiment, the invention relates to systems, methods, and apparatus relating to the detection of a neuropathy such as a periopertive neuropathy. In one embodiment, a wristband comprising a plurality of anodes and cathodes is used. The wristband can be a component in a electrode array that includes a plurality of reference or recording electrodes. The electrode array can be configured to stimulate and collect responsive signals from an ulnar, a median, radial and posterior tibial nerve. The simulation and signal collection can be performed on a continuous basis for time periods of interest such as a given perioperative time period using a monitoring device.

Abstract: An electrocardiographic device for sensing cardiac activity in a user, the electrocardiographic device comprising: plurality of electrodes provided at a surface of the device for electrical engagement with a pair of extremities of a user; one or more movement sensors arranged to, in use, detect movement of a user's extremities; and a control unit configured to receive electrical signals from the electrodes and to, in use, process said signals in dependence on the output of the one or more movement sensors so as to filter variations from the signals due to movement of the user's extremities.

Abstract: An anatomical mapping system includes a plurality of mapping electrodes each having an electrode location and configured to detect activation signals of intrinsic physiological activity within an anatomical structure. A mapping processor is associated with the plurality of mapping electrodes and is configured to record the detected activation signals and associate one of the plurality of mapping electrodes with each recorded activation signal. The mapping processor is further configured to analyze the recorded activation signals to identify at least one recurring pattern based on a relationship between a timing of the detected activation signals and the electrode locations of the mapping electrode associated with each detected activation signal.

Abstract: A coated electromyography needle including an anti-microbial, electrically insulative coating applied to non-tip portion of an electrode of the electromyography needle.

Abstract: A device, method, and system for monitoring the status of an internal part of a body using an electromagnetic transceiver operating in the microwave regime; a processing unit compares measured data with reference data to determine the status of the internal part. The solution may be arranged to continuously monitor the internal part of the body and the system may be arranged so as to be wearable or portable.

Abstract: A sensor element comprises a sensor section comprising a sensor unit configured to measure a physiological variable or any other signal in a living body and to generate a sensor signal in response to the variable or other signal, and a bond section comprising contact members configured to electrically connect at least one signal transmitting microcable. The bond section is coated with an electrically insulating material and the sensor unit is left uncoated. The sensor element may further comprise an intermediate section between the sensor section and the bond section. The intermediate section includes electric connection lines configured to connect the contact members to the sensor unit. The intermediate section is also coated with the electrically insulating material.

Abstract: Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.

Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a sequence control unit that controls a gradient magnetic field power supply, thereby performing a pulse sequence including the application of a continuous readout gradient magnetic field pulse. The sequence control unit controls the gradient magnetic field power supply such that the slew rate of the gradient magnetic field pulse is reduced in stages as the output voltage of a gradient magnetic field amplifier is reduced in stages.

Abstract: A magnetic resonance imaging (MRI) probe includes a coil section having an imaging coil, and a handle section connected to the coil section. The handle section has a phase shifter circuit with inductors, capacitors, and coax line electrically connected and is configured to provide appropriate phase shift. The handle section further has a coaxial cable winding electrically connected to the imaging coil, and wound cylindrically, and has a slot therethrough between the ends of the cylindrical winding. The handle section further has a pre-amp circuit mounted on a substrate and electrically connected to the cylindrical coax winding.

Abstract: A diagnostic system is disclosed, and comprises a diagnostic device and a fluid heat transfer system. The diagnostic device has an associated bed for supporting a portion of a subject during a diagnostic procedure. The fluid heat transfer system comprises a fluid circulation component, a heater component, and a fluid line. The heater component includes a heater element and a mixing valve, and the fluid circulation component is fluidly coupled to the heater component so that a fluid can be pumped from the fluid circulation component to the heater component. The fluid line extends from the heater to the fluid circulation component, and the mixing valve is positioned near the bed so that heat can be rapidly transferred through the fluid line to alter a body temperature of the subject.

Abstract: An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.

Abstract: A method and system for determining a pose of a subject. The subject is placed onto a surface of a platform having a first radio-frequency transceiver and a second radio-frequency transceiver. A first radio-frequency transponder is placed onto an upper extremity of the subject. A second radio-frequency transponder is placed onto a lower extremity of the subject. A first signal is transmitted from the first transceiver to the first transponder, resulting in the first transponder sending a second signal. A third signal is transmitted from the second transceiver to the second transponder, resulting in the second transponder sending a fourth signal. The second signal is received by the first transceiver. The fourth signal is received by the second transceiver. A pose of the subject is determined based on receiving the second signal and the fourth signal.

Abstract: A body fluid sampling device includes an expression member placed around an incision in the skin of a user, a compression member to contact and traverse the expression member, and a housing configured to contact the skin near the incision. The expression member is configured to repeatedly move from a relaxed position over the incision to a contracted position over the incision. The expression member is at least partially resilient in order to repeatedly squeeze and/or compress the skin around the incision.

Abstract: Provided are a blood collecting puncture device having high safety which can hygienically maintain the inside of a magazine and prevent infection, and the magazine. A blood collecting puncture device has a blood collecting puncture device body removably incorporating a magazine for housing lancets for puncturing human skin. The blood collecting puncture device body has a first housing section for housing not-yet-used lancets and a second housing section for housing used lancets to be disposed of. When a rotor is rotated, individual lancets are sequentially conveyed on a one-by-one basis to a stock position, a puncture position, and a disposal position, and this causes a not-yet-used lancet to be housed in the first housing section and also causes a used lancet to be housed in the second housing section, so that the lancets are separately housed in spaces isolated from each other.

Abstract: Devices and methods for positioning a portion of a sensor at a first predetermined location, displacing the portion of the sensor from the first predetermined location to a second predetermined location, and detecting one or signals associated with an analyte level of a patient at the second predetermined location are disclosed. Also provided are systems and kits for use in analyte monitoring.

Abstract: In particular embodiments, methods, devices and systems including calibrating analyte data associated with a monitored analyte level received from an analyte sensor based on a reference measurement, determining a lag time constant associated with the calibrated analyte data, and performing lag correction of the calibrated analyte data based on the determined time lag constant are disclosed.

Abstract: Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.

Abstract: A concentration determination apparatus in accordance with exemplary embodiments has a storage body and a temperature control plate. The concentration determination apparatus may also have a first and second input light guide and a first and second light receiving light guide, and an operational unit that contains an absorbance calculation device for calculating an absorbance of liquid and living body tissue and a concentration calculation device for comparing the absorbance of the liquid and the living body tissue.

Abstract: The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.

Abstract: A lancet enclosed in a sterility sheet forms a lancet packet to maintain the sterility of the lancet and prevent the lancet from unintentionally piercing the sterility sheet prior to lancet actuation. In one form, the lancet is immobilized by hot tack welding a portion of the sterility sheet to the lancet. Alternatively, portions of the sterility sheet are hot tack welded together through an opening in the lancet to limit movement of the lancet.

Abstract: Methods, systems, and apparatus for detecting an epileptic event, for example, a seizure in a patient using a medical device. The determination is performed by providing an autonomic signal indicative of the patient's autonomic activity; providing a neurologic signal indicative of the patient's neurological activity; and detecting an epileptic event based upon the autonomic signal and the neurologic signal.

Abstract: A sensor module can include a battery housing comprising a battery cavity sized and shaped to receive a battery. The battery cavity can be defined at least in part by a wall to be disposed about at least a portion of a periphery of the battery. A package housing can be disposed on the wall of the battery housing, the package housing smaller than the battery housing. An integrated device package can be disposed in or coupled with the package cavity. The integrated device package can include one or more integrated device dies. An interfacing feature can be coupled with the battery housing and extending transverse to the wall. The interfacing feature can be configured to transduce a biological signature into a signal to be processed by the integrated device package. An interconnect assembly can electrically connect the interfacing feature to the integrated device package.

Abstract: The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.

Abstract: Apparatus and method can be provided for obtaining information regarding at least one portion of a biological structure. For example, using a first arrangement, it is possible to generate a first electro-magnetic radiation to be forwarded to the portion and receive, from the portion, a second fluorescent radiation associated with the first electro-magnetic radiation Further, using a second arrangement, it is possible to obtain information associated with the second fluorescent radiation, and generate at least one image of the portion as a function of the second fluorescent radiation. According to an exemplary embodiment of the present invention, the first arrangement can be inserted into at least one lumen, and the image of the portion may be associated with the at least one lumen.

Abstract: At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert can be less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The insert includes a flexible articular surface. Flexible articular surface transfers loading to sensors internal to the insert.

Abstract: Method and system for providing a fault tolerant data receiver unit configured with a partitioned or separate processing units, each configured to perform a predetermined and/or specific processing associated with the one or more substantially non-overlapping functions of the data monitoring and management system is provided.

Abstract: An X-ray CT system including: a rotator including an X-ray tube installed therein; a gantry, arranged on a floor part, and configured to rotatably support the rotator; a cover configured to cover the rotator and the gantry from the outside; and an elastic member, and mounted along the lower edge of the cover, having restoring force, and configured to elastically be in contact with the floor part against the restoring force. The X-ray CT system can reduce noise from inside of the cover.

Abstract: A method of contrast-enhanced computed tomography (CT) imaging can include repeatedly scanning a target region at a frequency during a session, the frequency initially being a first rate. After detecting an increase of the attenuation of radiation by a contrast-enhanced first structure within a target region, the frequency can be increased to a second rate. After detecting a subsequent decrease in the attenuation, the frequency can be decreased to a third rate.

Abstract: A system and method using an inflatable jacket over the compression paddle of a mammography and/or tomosynthesis system to enhance imaging and improve patient comfort in x-ray breast imaging.

Abstract: A device for positioning a patient within an image volume of a cone-beam tomography system. The device includes a volume indicator adapted to indicate at least a front boundary of the image volume and having a horizontal indicator for horizontal alignment. The device also includes a head clamp adapted to position at least a portion of the head of the patient within the front boundary of the image volume indicated by the volume indicator.

Abstract: An extra-oral imaging system having a mount supported on a column that is adjustable in height, wherein the mount supports an x-ray source and at least one imaging sensor that are adjustable in height. A column base section remains stationary during height adjustment. A height sensing apparatus has a contact member that contacts a sensor element to provide a signal that is indicative of the height adjustment.

Abstract: A radiation imaging device includes plural individual detectors defining an irregular rectangular active area responsive to x-rays and with different widths along a length of the active area. The individual detectors may be of different rectangular shapes and mounted on a motherboard. The motherboard may be formed of a first module mounting a first of two individual detectors and a second module detachable connected to the first module and mounting a second of two individual detectors.

Abstract: An apparatus for obtaining an intraoral x-ray image from a patient has an x-ray source and an intraoral image detector comprising one or more detectable elements. One or more sensors are positionally coupled near the x-ray source and are energizable to sense the location of the one or more detectable elements when the intraoral image detector is within the patient's mouth. A control logic processor is in signal communication with the one or more sensors and is responsive to stored instructions for calculating a detector position of the intraoral image detector. A projector is positionally coupled to the x-ray source and is in signal communication with the control logic processor and is energizable to project an image toward the calculated intraoral image detector position in response to signals from the control logic processor.

Abstract: In Positron Emission Tomography, a time window (260) and an energy window (225) are dynamically adjusted, based on an attenuation map, count rate, clinical application, discrimination tailoring, and/or offline discrimination tailoring. Detected radiation events are filtered using the dynamically adjusted energy and time windows into scattered events, random events, and true events. The true events are input to image reconstruction, correction, and error analysis.

Abstract: Substantial reduction of the radiation dose in computed tomography (CT) imaging is shown using a machine-learning dose-reduction technique. Techniques are provided that (1) enhance low-radiation dosage images, beyond just reducing noise, and (2) may be combined with other approaches, such as adaptive exposure techniques and iterative reconstruction, for radiation dose reduction.

Abstract: The present disclosure provides systems and methods for evaluating a brain scan using reference data. Specifically, the systems and methods include a computed tomography (CT) scanner for the purpose of diagnosing concussions or mild traumatic brain injuries (mTBI). The system includes a multi-energy x-ray source (i.e., spectral CT), a photon counting x-ray detector, and a content-aware computer aided diagnostic (CAD) algorithm designed to detect imperceptible changes indicative of structural and physiological damage caused by a concussive event by comparing raw volumetric datasets of baseline (healthy) reference scan data to patient scan data taken after a concussive event.