Abstract: Provided is a standard plasmid for assaying a genetically modified plant, a method for quantitatively analyzing a target transgene within the genetically modified plant using the standard plasmid, and a kit for quantitatively analyzing the genetically modified plant including the standard plasmid, wherein the standard plasmid of the present invention is possible to be utilized for assaying a genome containing a 5-enoyl-4-pyruvylshikimate-3-phosphate synthase (EPSPS) gene or a cry1Ab gene, and in particular, significantly useful as a standard material capable of analyzing whether the genetically modified plant such as soybean RRS or GM maize MON810 is incorporated or an incorporation ratio thereof.

Abstract: Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.

Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nude is acid extraction.

Abstract: The present invention provides methods and systems for determining a woman's risk of carrying an aneuploid embryo based on the maternal genotype, maternal age and optionally paternal age.

Abstract: The level of miRNAs in a sample from a patient who has received a transplant is assayed and used as an indicator for transplant rejection. Based on the measured level of the miRNAs, therapeutic intervention, such as an immunosuppressant therapy, may be started, adjusted, continued or discontinued.

Abstract: The present invention provides novel mutations identified in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that can be used for a more accurate diagnosis of cystic fibrosis (CF) and CF related disorders. Methods for testing a sample obtained from a subject to determine the presence of one or more mutations in the CFTR gene are provided wherein the presence of one or more mutations indicates that the subject has CF or a CF related disorder, or is a carrier of a CFTR mutation.

Abstract: The invention described herein relates in part to compositions, biomarkers and methods for diagnosis and prognosis of prostate lesions, including prostate cancer, including a tissue-based assay providing diagnostic and prognostic information related to prostate cancer. In some embodiments, the invention further relates to improvements in the ability to accurately diagnose prostate cancer, detect early-stage prostate cancer, and localize prostate lesions within the three-dimensional space of the prostate.

Abstract: The invention provides methods for using the expression levels and subcellular localization of non-coding mitochondrial RNAs to select individuals or subpopulation of individuals for treatment with an anticancer therapy for multiple myeloma. Additional methods provided herein are useful for determining whether an individual in remission for multiple myeloma following successful treatment will be likely to suffer a relapse as well as to identify individuals who have suffered a relapse of multiple myeloma.

Abstract: Provided herein are biomarkers for evaluating malignant glioma.

Abstract: The present invention features methods, devices, and kits for predicting the sensitivity of a patient to a compound or medical treatment, such as fulvestrant.

Abstract: The invention provides methods to monitor cell free nucleic acids.

Abstract: The present disclosure describes a method for determining metastasis-free survival of a subject with cancer based on the differential expression of genes that are associated with metastasis of the cancer to the brain, bone and/or lung. Detection of the expression level of these genes in a sample from the subject can identify an individual who is at risk for metastasis.

Abstract: Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.

Abstract: Methods for identification of leukemia or a genetic predisposition to leukemia are provided that are particularly applicable to acute lymphoblastic leukemia (ALL). A novel heterozygous germline variant, c.547G>A (p.Gly183Ser) in the octapeptide domain of PAX5, is used to identify those individuals with an enhanced risk or predisposition to ALL.

Abstract: The present invention provides a method for monitoring the response to treatment in a patient undergoing breast cancer therapy, comprising detecting the presence of a loss-of-function-related genetic alteration in the PAPPA gene or its regulatory or promoter sequences in a sample obtained from the patient wherein if the genetic alteration is present but its quantitative level decreases during treatment, this is indicative of response to therapy, whereas, if there is no change or upward change in its quantitative level during therapy, this is indicative of non-response to therapy. The invention also relates to the use of specific biological markers for monitoring for relapse, and aiding the screening, primary diagnosis and staging of breast cancer.

Abstract: Described herein are non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer a body fluid sample from a subject. Further described herein are sets of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, described herein are sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject.

Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.

Abstract: A sex-determination method for a date palm plant includes obtaining a sample of a date palm plant and determining a presence or absence of the date palm SRY gene (SEQ ID NO: 1) in the sample. The presence of the date palm SRY gene (SEQ ID NO: 1) in the sample is indicative that the sample is from a male date palm plant. Using the sex determination method for a date palm plant, the sex of date palm plants may even be determined when the date palm plants are still young, i.e., prior to flowering of the plants.

Abstract: A method of operating a blast furnace by blowing a pulverized coal at an amount of not less than 150 kg/t?p from tuyeres through a lance into a blast furnace, wherein when the operation is performed under a condition that lump coke charged from a furnace top has a strength defined in JIS K2151 (DI15015) of not more than 87%, the pulverized coal blown through the tuyere contains not more than 60 mass % as a weight ratio of coal having a particle size of not more than 74 ?m and has an average volatile matter of not more than 25 mass %, and a blast temperature blown through the tuyere is not higher than 1100° C., oxygen is simultaneously blown into the furnace with the blowing of the pulverized coals through the lance and a gas having an oxygen concentration of 60 vol %-97 vol % is used as a carrier gas for the blowing of the pulverized coal.

Abstract: A heating apparatus, a heat treatment apparatus, and a heating method are provided. The heating apparatus includes a workpiece support on which a ring-shaped workpiece is placed, a rotary drive assembly, and a heater configured to heat the workpiece. The workpiece support includes a plurality of rotating rollers arranged in a circumferential direction. The rotary drive assembly is configured to rotate the plurality of rotating rollers to rotate the workpiece placed on the workpiece support along a ring shape of the workpiece. The heater includes a heating coil configured to induction-heat the workpiece on the workpiece support at a heating position, and an actuator configured to move the heating coil at the heating position relative to the workpiece to adjust a distance between the workpiece and the heating coil.

Abstract: In some aspects, a heat treatment process is described for precipitation hardening steel. The heat treatment process can include a solution treatment for a precipitation hardening steel part. The solution treatment includes heating the precipitation hardening steel part to an austenitizing temperature. The heat treatment process can also include a quenching or cooling treatment, in which the precipitation hardening steel part is cooled to a martensitizing temperature. The heat treatment process can also include an aging treatment, in which the precipitation hardening steel part is heated to a temperature of 1000° F. and held at that temperature for five or more hours until a fracture toughness of the precipitation hardening steel part is greater than 120 ksi?in.

Abstract: Forged precipitation-hardened stainless steel alloys are provided. The forged precipitation-hardened stainless steel alloy can include, by weight, about 14.0% to about 16.0% chromium, about 6.0% to about 8.0% nickel, about 1.25% to about 1.75% copper, about 1.0% to about 2.0% molybdenum, about 0.001% to about 0.05% carbon, a carbide forming element in an amount of about 0.3% to about 0.8% and greater than about 8 times that of carbon, the balance iron, and incidental impurities. Generally, the carbide forming element is selected from the group consisting of titanium, zirconium, tantalum, and a mixture thereof.

Abstract: A heating apparatus, a heat treatment apparatus, and a heating method are provided. The heating apparatus includes a workpiece support on which a ring-shaped workpiece is placed, a rotary drive assembly, and a heater configured to heat the workpiece. The workpiece support includes a plurality of rotating rollers arranged in a circumferential direction. The rotary drive assembly is configured to rotate the plurality of rotating rollers to rotate the workpiece placed on the workpiece support along a ring shape of the workpiece. The heater includes a heating coil configured to induction-heat the workpiece on the workpiece support at a heating position, and an actuator configured to move the heating coil at the heating position relative to the workpiece to adjust a distance between the workpiece and the heating coil.

Abstract: An abrasion-resistant steel material excellent in fatigue characteristics having a composition (in mass %) comprising 0.30 to 0.90% of C, 0.05 to 1.00% of Si, 0.10 to 1.50% of Mn, 0.003 to 0.030% of P, 0.001 to 0.020% of S, from 0.10 to 0.70% of Nb, and containing depending on necessity one or more of 1.50% or less of Cr, 0.50% or less of Mo, 0.50% or less of V, 2.00% or less of Ni, 0.10% or less of Ti, and 0.0050% or less of B, the balance Fe and unavoidable impurities, a metallic structure after a temper heat treatment having a Nb-containing carbide dispersed therein, the Nb-containing carbide particles having a particle diameter of 1.0 mm or more that is controlled to 200 particles per mm2 or more, and a maximum particle diameter Dmax of Nb-containing carbide particles in 103 mm3 that is controlled to 18.0 mm or less.

Abstract: There is provided a high strength hot rolled steel sheet having a composition comprising C: 0.040% to 0.100%, by mass %, Si: 0.50% or less, by mass %, Mn: 1.00% to 2.00%, by mass %, P: 0.03% or less, by mass %, S: 0.006% or less, by mass %, Al: 0.08% or less, by mass %, N: 0.0080% or less, by mass %, Ti: 0.14% to 0.22%, by mass %, and Fe and incidental impurities, and a method for making the same. The high strength hot rolled steel sheet includes a microstructure in which a primary phase is a ferrite phase and fine carbides containing Ti are dispersion-precipitated.

Abstract: One embodiment of the laser processing apparatus is for surface treatment by supplying liquid to a surface of the target member and irradiating pulsed laser light to the surface of the target member via the liquid. The apparatus includes a laser oscillator and a liquid supply. The laser oscillator irradiates the laser light to the surface through the liquid via an optical window. The liquid supply is configured to supply the liquid to the surface of the target member via a flow path passing on an outer surface of the optical window. When the liquid is in contact with a laser light emission surface of the optical window, the laser light emission surface transmits the laser light. When the liquid is not in contact with the laser light emission surface, the laser light emission surface reflects the laser light.

Abstract: The invention relates to a method for recovering at least one metal present within a material, said material possibly including iron, said method including a step of supplying a ferrous ion, a step of supplying a ferric ion, and a step of bioleaching at least one metal present in the material by the ferric ions, each one of the steps being implemented by a particular bacterial population.

Abstract: The present application offers a solution to the current problems associated with recovery and recycling of precious metals from scrap material, discard articles, and other items comprising one or more precious metals. The solution is premised on a microporous chelating polymeric membrane. Embodiments include, but are not limited to, microporous chelating polymeric membranes, device comprising the membranes, and methods of using and making the same.

Abstract: A zinc production method includes a reaction step such as a leaching step (101) of bringing electric arc furnace dust (1) containing zinc oxide or the like into contact with a chlorine gas (8) to obtain a zinc oxide component in the electric arc furnace dust (1) or the like as crude zinc chloride (3), a purification step (102) of heating the crude zinc chloride (3) obtained at the reaction step to produce zinc chloride vapor, and cooling and condensing the zinc chloride vapor, thereby obtaining purified zinc chloride (6), and an electrolysis step (103) of electrolyzing the purified zinc chloride (6) obtained at the purification step (102) in a molten state to obtain a zinc melt (9) and the chlorine gas (8).

Abstract: The disclosure describes a method of separating and recovering valuable metals from remanufacturing solution of a spent desulfurization catalyst containing vanadium, and more particularly, to a method of separating and recovering a valuable metal from remanufacturing solution of a spent desulfurization catalyst containing vanadium, which includes: adding organic acid to a spent hydrodesulfurization catalyst after collecting the spent hydrodesulfurization catalyst in order to prepare the remanufacturing solution of the spent hydrodesulfurization catalyst; adding an extracting agent and a diluent to the remanufacturing solution to extract molybdenum and extracting vanadium from an extracted filtrate to obtain an organic phase; and adding a stripping agent to the organic phase to strip and recover vanadium.

Abstract: A method for purification and separation of mixed elements, comprising at least a first free flow electrophoresis separation chamber, wherein a solution of the mixed elements is passed through the first separation chamber, an electric field submitted perpendicular to the solution flow and separating mobile ions of the solution based on electrophoretic mobility. A continuous method comprises selecting a complexing ligand, and controlling the temperature and pH of the solution.

Abstract: Methods for extraction and recovery of rare earth elements are disclosed. In one aspect, heap leaching with a leach solution comprising sulfuric acid is used to extract rare earth elements including yttrium and light and heavy rare earth elements.

Abstract: A palladium-based alloy including, expressed in weight, between 50 and 55% of palladium, between 45% and 50% of rhodium; a quantity x of silver where 0%?x?5%, and a quantity R of a balance including at least one element selected from among iridium, ruthenium, platinum, titanium, zirconium and rhenium and combinations thereof, where 0%?R?5%. The invention also relates to a A timepiece or piece of jewellery including at least one component made of such an alloy.

Abstract: One aspect of this copper alloy for an electronic and electrical equipment contains: more than 2.0 mass % to 36.5 mass % of Zn; 0.10 mass % to 0.90 mass % of Sn; 0.15 mass % to less than 1.00 mass % of Ni; and 0.005 mass % to 0.100 mass % of P, with the balance containing Cu and inevitable impurities, wherein atomic ratios of amounts of elements satisfy 3.0<Ni/P<100.0 and 0.10<Sn/Ni<2.90, and Vickers hardness of a surface of an ? phase containing Cu, Zn, and Sn is 100 or more.

Abstract: An aluminum alloy having excellent formability and elasticity includes Ti, B, Mg, and the Al, wherein a composition ratio of Ti: B: Mg is 1:3.5˜4.5:1, and AlB2 and TiB2 are present as reinforcing phases.

Abstract: An aluminum alloy for an engine piston of an automobile may be composed of Ti, B, Cu and the balance of Al and may include a TiB2 phase as a reinforcing phase. A composition weight ratio of Ti:B:Cu is 0.5 to 2.5:1:1 to 1.3. The aluminum alloy may have excellent elasticity, thermal properties, and formability by maximizing a generation of a TiB2 reinforcing phase.

Abstract: An aluminum alloy includes, in weight percent, 0.50-1.30% Si, 0.2-0.60% Fe, 0.15% max Cu, 0.5-0.90% Mn, 0.6-1.0% Mg, and 0.20% max Cr, the balance being aluminum and unavoidable impurities. The alloy may include excess Mg over the amount that can be occupied by Mg—Si precipitates. The alloy may be utilized as a matrix material for a composite that includes a filler material dispersed in the matrix material. One such composite may include boron carbide as a filler material, and the resultant composite may be used for neutron shielding applications.

Abstract: A graphite spheroidizing agent containing: 30-80 wt % of Si; Mg; RE (rare earth element) which comprises Ce with a purity level of 80-100 wt % or La with a purity level of 80-100 wt %; Ca; and Al is used. The graphite spheroidizing agent is added so as to satisfy the conditions that an amount of RE equivalent to 0.001-0.009 wt % of the total weight of the molten metal, an amount of Ca equivalent to 0.001-0.02 wt % of the total weight of the molten metal, and an amount of Al equivalent to 0.001-0.02 wt % of the total weight of the molten metal are added to the molten metal, and that the molten metal contains 0.03-0.07 wt % of Mg after the graphite spheroidizing treatment. It is possible to suppress crystallization of chunky graphite in a thick section of spheroidal graphite cast iron and deterioration of mechanical properties, with a low cost.

Abstract: A soft magnetic alloy according to an embodiment of the present invention has a composition of the following Chemical formula: Fe100-a-bSiaCrb??[Chemical Formula] where a is in a range of 1 to 7 at %, b is in a range of 3.5 to 17 at % and a+b is in a range of 10.5 to 18 at %.

Abstract: A high strength hot rolled steel sheet with good formability, which has good magnetic properties, excellent punchability, and a tensile strength of 780 MPa or more. The high strength hot rolled steel sheet having a chemical composition containing C: 0.070% to 0.140%, Si: 0.10% to 1.00%, Mn: 1.00% to 1.80%, P: 0.050% or less, S: 0.0050% or less, N: 0.0080% or less, Al: 0.010% to 0.100%, Ti: 0.050% to 0.150%, and the remainder composed of Fe and incidental impurities, on a percent by mass basis, and 95% or more of bainite microstructure on a volume fraction basis, wherein carbides constituting 80% or more of total precipitation carbides are dispersed at grain boundaries of bainitic ferrite constituting the bainite microstructure and 80% or more of total precipitation carbides have particle grain sizes of 20 to 300 nm.

Abstract: A carbon steel for use in high pressure hydrogen service is provided. This steel may have greater than 1.20% manganese and greater than 0.035% sulfur. This steel may have no more than 0.16% carbon, no more than 1.10% manganese, no more than 0.010% phosphorus, no more than 0.05% sulfur, no more than 0.02% silicon, no more than 0.15% copper, no more than 0.10% nickel, no more than 0.1% chromium, no more than 0.03% molybdnium, no more than 0.40% aluminum, no more than 0.02% vanadium, no more than 0.0005% boron, no more than 0.003% titanium, and no more than 0.02% niobium.

Abstract: A carbon steel for use in high pressure hydrogen service is provided. This steel may have greater than 1.20% manganese and greater than 0.035% sulfur. This steel may have no more than 0.16% carbon, no more than 1.10% manganese, no more than 0.010% phosphorus, no more than 0.05% sulfur, no more than 0.02% silicon, no more than 0.15% copper, no more than 0.10% nickel, no more than 0.1% chromium, no more than 0.03% molybdnium, no more than 0.40% aluminum, no more than 0.02% vanadium, no more than 0.0005% boron, no more than 0.003% titanium, and no more than 0.02% niobium.

Abstract: The present invention concerns a new metal powder which is useful for coating cast iron parts. The invention also relates to a method for coating cast iron parts by using the new metal powder. Of special importance is the possibility to use the metal powder for coating the surfaces of glass moulds. The invention also relates to metal parts, such as cast iron parts, or glass moulds which are coated by the metal powder.

Abstract: A cold work tool steel with average or above wear resistance, a hardness in excess of 60 HRc and a very good toughness but with considerably lower carbon contents leading to highly improved weldability is obtained by combining the presence of primary carbides (or alternatively nitrides and/or borides) with other strengthening mechanisms like precipitation hardening or even solid solution. Vanadium rich MC type carbides, modified with refractory metal additions, present the best compromise of hardness and fracture toughness for several applications, while for other applications harder carbides, such as Ti carbides or Ti mixed carbides (primarily with V, Mo and/or W) will be the preferred ones, alternatively using Zr and Hf mixed carbides.

Abstract: An energy-storing container is made of a lightweight steel having the following chemical composition (in wt %): C 0.04-2%; Mn 14-30%; Al 1.5-12%; Si 0.3-3%; Cr 0.12-6%, and additionally one or more of the following elements: Ti, V, Nb, B, Zr, Mo, Ni, Cu, W, Co, P, N, each at up to 5% and in total at up to 10%, wherein the remainder is Fe including common steel tramp elements, wherein the concrete alloy composition is selected in order to limit the ??-martensite fraction before or after a forming process to no more than 3%, with the stipulation that the ??-martensite equivalent according to 0.1*wt % Mn wt % C 0.05*wt % Si is between 3.4 and 10.5.

Abstract: The present invention relates to a method of manufacturing a metal matrix composite component (9). It comprises the use of a container (1) having a first compartment (2) and a second compartment (3) interconnected by a passage (4). A porous reinforcement preform (6) is placed in the first compartment (2), and matrix metal (7) is placed in the second compartment (3). The container (1) is then evacuated and sealed. The container (1) and its content is heated to above a melting temperature of the matrix metal (7) at least until the matrix metal (7) has melted. Then a high pressure P is applied to the outside of the container (1) so that at least the second compartment (3) is deformed to such an extent that melted matrix metal (7) is forced to flow via the passage (4) into the first compartment (2) and to infiltrate the porous reinforcement preform (6). The method may preferably be carried out in a hot isostatic pressure vessel (8).

Abstract: A bioabsorbable material composition includes magnesium (Mg), lithium (Li) and calcium (Ca). Lithium is provided in a sufficient amount to enhance material ductility, while also being provided in a sufficiently low amount to maintain corrosion resistance at suitable levels. Calcium is provided in a sufficient amount to enhance mechanical strength and/or further influence the rate of corrosion, while also being provided in a sufficiently low amount to preserve material ductility. The resultant ductile base material may be cold-worked to enhance strength, such as for medical applications. In one application, the material may be drawn into a fine wire, which may be used to create resorbable structures for use in vivo such as stents.

Abstract: Processes for forming an article from an ?+? titanium alloy are disclosed. The ?+? titanium alloy includes, in weight percentages, from 2.90 to 5.00 aluminum, from 2.00 to 3.00 vanadium, from 0.40 to 2.00 iron, and from 0.10 to 0.30 oxygen. The ?+? titanium alloy is cold worked at a temperature in the range of ambient temperature to 500° F., and then aged at a temperature in the range of 700° F. to 1200° F.

Abstract: A method of producing substrate having an antimicrobial surface by thermally spraying the surface with metals such as copper and alloys of copper, silver and alloys of silver, zinc and alloys of zinc, tin and alloys of tin and combination thereof and thereafter abrading the sprayed surface to give the surface antimicrobial properties.

Abstract: A plurality of layers are laminated on at least part of the member under treatment made of steel, the plurality of layers having carbon concentrations higher than that of the member under treatment and 1.0 wt. % or less, the carbon concentration of an outermost layer of the plurality of layers being the highest. A method for manufacturing a steel part, including spraying powder containing carbon on at least part of an member under treatment made of steel so as to form a first layer having a carbon concentration higher than that of the member under treatment and spraying powder containing carbon on at least part of the first layer so as to form a second layer having a carbon concentration higher than that of the first layer. Carbon concentrations of a plurality of layers including the first layer and the second layer are 1.0 wt. % or less.