Abstract: Implantable medical devices, and methods of coating same, including a plurality of components disposed on a substrate, and a low surface energy layer deposited as a liquid over at least a first portion of the components and the substrate, the low surface energy layer becoming solidified after deposition and conforming to at least the first portion of the components. The devices further include a biocompatible hermetic coating conforming to and sealingly covering at least a portion of the low surface energy layer.

Abstract: A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a drug delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract: A medical assembly is disclosed comprises a stent and a catheter having a balloon, wherein the coefficient of friction and/or the adhesion at the stent/balloon interface are reduced.

Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.

Abstract: Techniques, mixtures and improved porous materials (interconnected porous constructs) that are capable of maintaining a sufficient porosity while conferring improved mechanical and physical strength to the final construct. A sacrificial construct (for example, a sacrificial material such as polymethyl methacrylate (PMMA)) is used to obtain an inverse porosity of the construct it was molded into. The process provides a less porous end material that may be used as an arthroplasty device or surgical implant (for example, an interference screw of suture anchor) among many other applications. The process employs a sacrificial material to reduce the porosity of the final construct to about 35%.

Abstract: The present invention relates to methods for in situ treatment of malignant cells from a cancer associated with bone. In one method, the treatment is for a primary cancer and entails positioning an implant containing and/or coated with at least one active agent for treating malignant cells directly in/on or indirectly among/near (e.g., by placing the implant in an area immediately proximal to) a site containing the malignant cells. In another method, the treatment includes positioning an implant containing and/or coated with at least one active agent for treating malignant cells directly in/on or indirectly among/near (e.g., by placing the implant in an area immediately proximal to) a surgical site from which malignant cells were previously removed/excised.

Abstract: A marker alloy foreign implant made of a biodegradable metallic material and having the composition MgxYbyMz wherein x is equal to 10-60 atomic percent; y is equal to 40-90 atomic percent; z is equal to 0-10 atomic percent; M is one or more element selected from the group consisting of Ag, Zn, Au, Ga, Pd, Pt, Al, Sn, Ca, Nd, Ba, Si, and Ge; and wherein x, y, and z, together, and including contaminants caused by production, result in 100 atomic percent.

Abstract: A suction canister cover is intended to hide the contents of a suction canister during a medical procedure from patients and other non-medical personnel who may become queasy at the sight of bodily fluids. The suction canister cover includes a base cover, a tubular lateral cover, an annular restraint, and a viewport. The base cover hides the bottom of the suction canister while the tubular lateral cover obscures the patients view through the sides of the suction canister. The annular restraint secures the suction canister cover to the suction canister to prevent the suction canister cover from being easily removed or sliding from the suction canister. The viewport allows medical personnel to view the volume of contents within the suction canister while keeping the contents blocked from patients and non-medical personnel.

Abstract: Reduced-pressure sources, systems, and methods involve using a vacuum pump that is disposed within a sealed space to produce reduced pressure. The exhaust from the vacuum pump is exhausted from the sealed space through pores in an enclosure member that is made of a polymeric, porous, hydrophobic material. Other devices, systems, and methods are disclosed.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: A reduced-pressure treatment system for treating a tissue site on a patient includes a gasket releasably attached around a perimeter of the tissue site that may remain in place for an extended time and allows an over-drape to be attached to it. The system and method further may include a manifold sized and configured to be placed in contact with the tissue site; the over-drape positioned over the manifold and sealed to the gasket to create a sealed space between the over-drape and the tissue site; and a reduced-pressure source fluidly coupled to the sealed space to deliver reduced pressure to the tissue site. A method is also presented.

Abstract: The invention relates to a ventricular assist device for intraventricular placement inside a human heart including an anchor element configured to be mounted to the heart in the region of the apex; and a pump connected to the anchor element comprising a preferably tubular housing having an intraventricular inlet and an intraventricular outlet and further comprising a drive for driving a rotor arranged within the housing, thereby providing pulsatile flow acceleration in the left ventricle synchronized with the heart beat and according to volume requirements in the left ventricle.

Abstract: The invention relates to a dialysis device (1) having a dialysate circuit comprising a first dialyzer (3) and a second dialyzer (5) wherein the first dialyzer (3) is connectable to a blood circulation of a patient via a blood feed line (11) and a recirculation (13), an effluent for a retentate flow (Qeffluent) from the dialysate circuit to the second dialyzer (5) is provided and a permetate stream (Qout) of the second dialyzer (5) in the dialysate circuit is passed to the first dialyzer (3), the second dialyzer (5) comprising a filter membrane having a cut-off value of at least 500 Da and the first dialyzer (3) comprising a filter membrane having a cut-off value exceeding that of the second dialyzer (5).

Abstract: A fluid filtration system comprising a cross-flow filter is arranged to permit a first pump to recirculate part of the retentate of the filter to the inlet of the cross-flow filter and a second pump to return part of the permeate to the inlet of the cross-flow filter. A third pump is configured supply source fluid to the inlet of the filter. The flow path between the second pump and the cross-flow filter inlet may include an adsorption filter that may selectively remove contaminants, toxins, or pathogens in the permeate. A controller may control the first, second and third pumps to provide predetermined flow ratios among the fluid flow paths of the system in order to achieve a desired filtration level. This system may be applicable to the removal of harmful substances from blood, by first separating the plasma from the blood and then removing harmful substances from the plasma.

Abstract: Prior to each treatment session for an individual patient, a machine controller in a dialysis machine obtains from a logic device a set of current control settings of the machine-related parameters to be applied in the treatment session. In generating the control settings, the logic device obtains a set of therapeutic targets comprising a target value that represents part of a desired status of the patient after the treatment session, in terms of one or more physiological parameters for the patient. The logic device also obtains status data that represents the current status of the patient prior to the treatment session, and computes the set of current control settings of the machine-related parameters, as a function of the set of therapeutic targets and the status data and at least partly based on a predictive model, which estimates the physiological response of the patient to the machine-related parameters during the treatment session.

Abstract: A convenience kit, use of which transforms a conventional IV container spiking and dispensing system to a safety system for handling hazardous drugs. The kit provides a spike receiving subsystem which is interposed between a spike of an IV set and a needle-less syringe connector affixed to a hazardous drug containing IV container to provide a closed pathway for delivering the hazardous drugs and to allow for detaching a spent container without exposing the hazardous drugs to a surrounding environment.

Abstract: The present invention is a device and system to permit the isolation of two fluid compounds to be delivered to a patient without intermingling the two fluid compounds, yet permitting the labor saving activity of permitting a nurse or other medical staff member to hang two IV bags simultaneously. Fluid from the first IV bag inflates the barrier pressure valve and seals the system against the intrusion of the second fluid from the second IV bag until the first fluid has been fully delivered. The barrier pressure valve then unseals the system to permit the flow of fluid from the second IV bag to the patient. This implementation permits this isolation and separate delivery of two fluids without using electronics or other technology that would require a battery backup or other uninterruptible power source.

Abstract: A pumping device that can be used with currently-available pressure bag infusers is disclosed. The pumping device is hand-held and lightweight. The device is controlled by a microprocessor. Thus constant pressure to the bag is maintained through automatic adjustment of pumping and venting functions. In addition, a novel, new pressure bag infuser and a modified Luer Lock fitting for use with the pumping device are described.

Abstract: An injection device for injecting a fluid into an object, the injection device including a plunger assembly for operative engagement with a syringe adapted to contain the fluid and permit ejection of the fluid therefrom via a syringe outlet, the plunger assembly being displaceable in a first direction which causes at least some of the fluid contained in the syringe to be ejected from the syringe via the syringe outlet and an inadvertent fluid ejection prevention assembly coupled to the plunger assembly for preventing ejection of fluid from the syringe in situations where the syringe outlet is neither in operative engagement with a vial adaptor suitable for providing fluid communication with the interior of a vial nor in fluid communication with an injection site within the object.

Abstract: A cartridge holder for a drug delivery device. The cartridge holder comprises a proximal portion for receiving a cartridge filled with a medicinal fluid to be dispensed by the drug delivery device, and a distal portion comprising a mount for a piercing assembly. The piercing assembly is adapted to provide a fluid-transferring connection with the inner volume of the cartridge by way of a piercing element pointing in distal direction with a pointed free end section. Retaining means adapted to substantially prevent the cartridge from displacing in proximal direction with respect to the proximal portion distal portion.

Abstract: The dental instrument includes a syringe and a topical anesthetic dispenser that is slidably attached to the syringe. The topical anesthetic dispenser can include a dispenser plunger, a dispenser barrel that slidably engages the dispenser plunger, a dispenser tube, and a needle cover affixed to the dispenser tube. The syringe can include a syringe plunger, a syringe barrel that slidably engages the syringe plunger, and a hollow needle having a beveled front end and a rear end extending toward the syringe barrel. A first carpule containing topical anesthetic can be loaded in the dispenser barrel. A second carpule containing injectable anesthetic solution can be loaded in the syringe barrel.

Abstract: Described is an autoinjector comprising a case, a drive carriage disposed in the case, and a plunger coupled to the drive carriage. The plunger is adapted to releasably engage a needle retraction mechanism in a syringe. Translation of the drive carriage in a distal direction relative to the case causes the plunger to engage the needle retraction mechanism and translation of the drive carriage in a proximal direction relative to the casing case the plunger to needle retraction mechanism the stopper.

Abstract: A device for delivering a medicament intradermally includes a cartridge (112) having a first end (110) and a second end (114) and defining a volume (111) therebetween. The volume (111) is adapted to contain the medicament. A driving member (121) has a first end (126) and a second end (128). The first end (126) of the driving member (121) is disposed in the cartridge (112) and the second end (128) of the driving member (121) is disposed outside the cartridge (112). A stopper (115) is slidably disposed in the cartridge volume (111). The driving member (121) is releasably disposed in the stopper (115) such that when the driving member (121) is retracted from the cartridge (112) the stopper (115) is disengaged from the driving member (121) and remains in the cartridge volume (111).

Abstract: Extension rods of a telescoping assembly (TSA) may be assembled in a single direction. The rods may optionally be threaded together from a reverse extended configuration. The rods may optionally resist disattachement during extension. The inner rod may optionally included a leading fastener and/or the outer rod may optionally include a rear fastener. Each rod may optionally be molded as a single piece. End caps may optionally be added to the TSA after extension of the rods. An end cap may optionally include a rotation stopper. In some embodiments the TSA may include a supporting shoulder.

Abstract: A gasket for use in a syringe so formed as to liquid-tightly and slidably contact an inner surface of an outer cylinder of the syringe, the gasket including a gasket body made of an elastic body and a coating layer formed on a portion thereof which contacts at least the syringe, wherein the coating layer includes a composition containing a silicone resin which includes a condensate of a reactive silicone resin having a terminal silanol group and which has a siloxane bond derived from the silanol group, and does not contain solid fine particles.

Abstract: The invention relates to a disposable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver.

Abstract: A dose control mechanism for a syringe includes a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle. The syringe may be a fill-at-time-of-use syringe, a pre-filled syringe, or a safety syringe having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.

Abstract: A method and system for proving a drug delivery device having a variable dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first and second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device.

Abstract: The invention relates to a reusable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver.

Abstract: A syringe includes a body for receiving a medicament and a plunger movably connected to the syringe body. The plunger is moved with respect to the syringe body to draw in and dispense the medicament. A plurality of dose setting indicators are disposed on the plunger. The plunger is rotated outwardly from the syringe body to draw medicament into the syringe body. The plunger can be pushed or rotated into the syringe body to dispense the medicament.

Abstract: A needle safety lock comprising a needle guard supporting member (14), and a needle guard (16) comprising an elongate member coupled to said needle guard supporting member and axially slideable with respect to the needle guard supporting member, and a cylindrical guard (20) having two open ends to enclose at least a portion of a needle; wherein the needle guard comprises a locking means to selectively secure the needle guard in a first locking position that is releasable or a second locking position that is non-releasable; and wherein when the needle guard is in the first or second locking position free axial movement of the needle guard is prevented.

Abstract: Medicament delivery device comprising a housing (10) and container holder (12) accommodating a multi-chamber medicament container wherein said housing and said medicament container holder are interactively connected to and movable relative each other; a mixing guard mechanism interactively connected to the body for driving the medicament container holder within the housing achieving a reconstitution, wherein the mixing guard mechanism comprises a guard member (34), a force member (52), a guard member locking means (24, 42) whereby, when the reconstitution is achieved, the medicament container holder and the guard member are movable in relation to said housing from a pre-mix position to a mixed position wherein said medicament container holder has been displaced distally in relation to said housing, at which mixed position said guard member locking means is activated, whereby said guard member is forced in the proximal direction by said force member for covering the delivery member (22).

Abstract: The invention is related to an apparatus comprising: a valve body comprising two inlet openings, one outlet opening and a central space connecting the inlet openings and the outlet opening, and a spherical element movably contained inside the central space configured for translatory movement and configured to seal either the first inlet opening or the second inlet opening, wherein each of the inlet openings are configured for fluid communication with a first reservoir and with a second reservoir and wherein the outlet opening is configured for fluid connection with a septum. This apparatus solves the object to make the exchange of used parts including the valve construction less complex. A further object of the invention is to make the exchange easier to handle. The invention is also related to a medical device comprising a dispense interface and an apparatus of the afore-mentioned type.

Abstract: A molding assembly for molding a syringe with a needle embedded therein includes a first mold portion and a second mold portion. The second mold portion includes a molding block, an end plate and a needle holding block configured to hold the needle. The assembly moves between an opened position in which the first mold portion is displaced from the second mold portion, and a closed position in which the molding block and the end plate define a molding cavity configured to form a body portion of the syringe, and the first mold portion contacts the second mold portion to hold the needle holding block adjacent to the molding cavity, such that the needle is partially positioned within the molding cavity.

Abstract: The present invention relates to a washing water spraying vessel for a nasal cavity cleaner. A pumping operation of a pumping member is performed only when a pair of buttons formed on both sides of an outer cap are simultaneously pressed, which allows enabling fundamentally blocking the pumping operation through external pressure unintended by a user, thereby not only preventing washing water from being unnecessarily consumed but also preventing an inner part of the overcap from being contaminated.

Abstract: The present invention relates to an inhaler which is appropriate for delivery of medicament in dry powder form used in respiratory diseases, particularly in asthma and chronic obstructive pulmonary disease (COPD). In addition, the present invention relates to an inhaler which includes a blister package appropriate for carrying the medicament in dry powder form and used to realize an effective inhalation.

Abstract: A device (10) for capturing a surface of an object (30) is provided, wherein the device (10) comprises a flexible membrane (14), which is configured to be deformed from a first shape to a second shape, when at least a part of the flexible membrane (14) is brought into contact with the surface of the object (30), wherein the device (10) comprises a plurality of strain-gauges (18) coupled to the flexible membrane (14), wherein the strain-gauges (18) are configured to measure a plurality of strain signals that depend on the shape of the flexible membrane (14), and wherein the device (10) comprises an output unit (24) for outputting the strain signals for reconstruction of the surface of the object (30) as a function of the strain signals.

Abstract: A ventilator, or a breathing assistance apparatus, is disclosed to ventilate patients who may have breathing difficulties, said device comprising a inspiratory pressure control duct configured to be immersed in a first body of fluid; a positive end-expiratory pressure control duct configured to be immersed in a second body of fluid; at least one valve connected to the peak inspiratory pressure control duct and to the positive end-expiratory pressure control duct, and at least one controller communicably connected to the valve to control rate of cycling of the valve, thereby controlling number of breaths per minute, and to control the duration of peak inspiratory pressure also known as inspiratory time.

Abstract: Provided is a direction switching valve unit and a cough assisting device using the same for inhaling to and exhaling from a patient's respiratory organ to induce a cough, the cough assisting device has a case body (100) having an inhaling space (110) formed on and passing through a lower surface thereof; an air pressure generating unit (200) provided in the case body (100), the air pressure generating unit generating an air pressure through a rotation force for suctioning air into an air inlet (210) and discharging suctioned air via an air outlet (220); a direction switching valve unit (300) provided in the inhaling space (110) formed through the case body (100), the direction switching valve unit converting a flow direction of the air for forcedly suctioning air toward a patient's respiratory organ or forcedly discharging air from a patient's respiratory organ by means of air pressure generated in the air pressure generating unit (200), whereby the device can be operated with low electric power.

Abstract: A float tent can include: a frame having a pool frame portion with a tent frame portion thereof over the pool frame portion; a tent having the tent frame portion, the tent having a closable opening; and a pool having the pool frame portion, the pool having pool sides dimensioned to hold at least 8 inches of water and having a pool base dimension sufficient for a person to lay in the pool without touching pool sides. The tent can include tent walls having an angle that inhibits condensation drip, the angle being with respect to the pool base, such as at least 4.5 degrees. The tent can include a material that is opaque. The float tent can include a heater configured to heat the water to skin temperature of the person. The float tent can include a water circulation pump and filter.

Abstract: A tube assembly including a flexible tube joined to a connector with the tube having an insert liner located therein at least in an area of a distal end of the connector that provides improved retention force between the tube and connector. Methods for preparing the tube assembly are disclosed and include the use of adhesives or solvent for bonding the tube to the connector.

Abstract: A distal tip protector, protection shield, or packaging insert to protect the distal segment of a guidewire projecting from a guidewire carrier.

Abstract: A catheter grip and catheter assembly are provided. The catheter grip includes a body portion adapted to extend circumferentially around a catheter shaft of the catheter assembly to facilitate gripping of the catheter shaft by a user. The catheter grip also includes a head portion through which the catheter shaft can be fed and a biasing mechanism. The biasing mechanism biases the body portion and the head portion away from one another.

Abstract: A medical catheter (1) comprising an inner catheter tube (2) and an outer catheter tube (3), wherein the inner catheter tube (2) has at least one outlet port (6) for a medical liquid at its distal end and the outer catheter tube comprises two parts of differing rigidities, namely a flexible part (5) and a rigid part (4), wherein the flexible (5) part is located at the distal end of the outer catheter tube (3) and the distal end of the flexible part (5) is connected to the inner catheter tube (2), and wherein the medical catheter also comprises a drive means (7) for generating a relative movement between the inner catheter tube (2) and the rigid part (4) of the outer catheter tube (3).

Abstract: The invention relates to an injection catheter for delivering a therapeutic agent into a substrate, comprising one or more lumens and a curved delivery element, said lumen serving as a guide for said curved delivery element outside of the substrate; said curved delivery element comprising openings on its distal tip, said distal tip comprising a distal zone and a proximal zone, said injection catheter being characterized in that the specific surface in said distal zone of said distal tip of said curved delivery element is higher than the specific surface in said proximal zone of said distal tip of said curved delivery element. The invention also relates to a process for delivering a therapeutic agent into a substrate.

Abstract: A system of catheter devices and methods for forming channels or passageways between a luminal anatomical structure (e.g., a blood vessel) and a target location (e.g., another blood vessel, an organ, a mass of tissue, etc.) for the purpose of rerouting blood flow or for delivering a substance or instrument, etc. to the target location.

Abstract: A combined hemostasis valve and drive mechanism is provided. The hemostasis valve has a valve body with a first and second leg. The first leg has a proximal port, a distal port and a lumen extending between the proximal port and the distal port. At least one valve is located in the lumen adjacent the proximal port to permit an interventional device to be passed therethrough. The second leg extends at an angle relative to the first leg and is in fluid communication with the first leg. A rotating male luer lock connector is rotatably connected to the first leg proximate to the distal port. It is configured to secure a guide catheter and has a driven member. The drive mechanism has a drive member removably interfacing with the driven member and a motor operatively connected to the drive member.

Abstract: A bi-directional catheter with nearly double the throw in its catheter tip deflection defines a puller wire travel path having a U-turn a pulley which minimizes the offset angle between the puller wire and the longitudinal axis of the control handle while maximizing the travel distance of that puller wire for any given distance traveled by the pulley drawing the puller wire. In particular, the control handle of the catheter which includes a steering assembly having a lever arm carrying a pair of pulleys for drawing corresponding puller wires to deflect the tip section of the catheter. The pulleys are rotatably mounted on opposing portions of the lever arm such that one pulley is moved distally as the other pulley is moved proximally when the lever arm is rotated.

Abstract: A vascular access needle assembly is disclosed. The needle assembly contains a needle and a sheath. The needle has a first part, a second part, and a third part. The needle contains a pointed end configured to penetrate skin of a patient and a sheath slidably and rotatably coupled with the needle. The sheath having one or more irrigation slots configured to transmit a fluid from a fluid source to a vascular region.

Abstract: The invention relates to a needle tip guard for a safety IV catheter assembly comprising a catheter tube having a distal end and a proximal end; a catheter hub having a distal end and a proximal end, wherein the distal end is joined to the said catheter tube and the proximal end defines a chamber; a needle extending through the catheter hub and the catheter tube having opposite proximal and distal ends defining an axial direction A, wherein the proximal end is joined to the needle hub and the distal end forms a sharp tip and a change in profile is provided between the proximal and distal ends of the needle; and a tip protector assembly movably arranged in between the catheter hub and needle hub on the needle such that the tip protector assembly is retained partially and/or completely in the chamber of the catheter hub and wherein the tip protector assembly is configured to entrap the needle tip upon withdrawal of the needle from the catheter hub.