Abstract: A bending operating member for performing a bending operation on an elongated member having flexibility in a direction intersecting an axial direction of the elongated member, the bending operating member includes a pulling member, at least a portion of the pulling member being configured to be connected to a distal portion of the elongated member such that, when the pulling member is pulled in the axial direction of the elongated member, the pulling member causes the elongated member to bend; a moving member that is connected to the pulling member, the moving member being configured to move so as to pull the pulling member in the axial direction of the elongated member; a rotating member that is operatively connected to the moving member and is rotatable around a longitudinal axis of the elongated member; and a converting part that converts rotation of the rotating member into movement of the moving member.

Abstract: A method comprises providing a balloon catheter device; locating a balloon portion within a paranasal sinus ostium while the balloon portion is in the first position such that a distal end of the balloon portion is at a distal end of a paranasal sinus ostium; inflating the balloon portion while the balloon portion is located in the paranasal sinus ostium such that at least a portion of the paranasal sinus ostium is dilated; sliding the balloon portion back to a second position while leaving the distal end of a guide member at the distal end of the paranasal sinus ostium; and viewing an image provided by a camera to determine whether an entirety of the paranasal sinus ostium has been dilated.

Abstract: A nasal cavity administration container includes a body section including a medical fluid storage section having an opening and a plunger having a pressing part, and a plunger moving amount regulation member having a stopper and being engaged with the body section, an engagement with the body section being relieved only in a state where the pressing part abuts on the stopper. When the plunger is pushed into the medical fluid storage section, the plunger moves forward until the pressing part abuts on the stopper. The plunger is further pushed into the medical fluid storage section with the plunger moving amount regulation member detached from the body section. The nasal cavity administration container can administer a medical fluid easily and appropriately.

Abstract: A device implantable in tissue of a prostate gland or a bladder is described. The device includes a device body, a retrieval portion, a medicament, and a medicament carrier. The device body includes a first end and a second end opposite of the first end. The first end has a sharp tip adapted for penetrating the tissue. The retrieval portion connected to the second end of the device body. The medicament is applied to the device to therapeutically treat the prostate gland or the bladder. The carrier is a hydrogel, a silicone based material, an elastomer, a proteinaceous material, a polyethylene glycol material, a carbohydrate material, or a polysaccharide carbohydrate material that provides controlled delivery of the medicament over a duration of time.

Abstract: The present invention provides an anti-microbial or anti-bacterial treated soft ointment applicator that is used to apply ointment or cream on babies. The ointment applicator with a soft and flexible tapered tip in the present invention can be applied along the curvature of a baby's body without causing harm to baby's sensitive and delicate skin. The present invention provides an anti-microbial or anti-bacterial treated ointment applicator either coated with, or homogeneously manufactured with, such anti-microbial or anti-bacterial protection. In addition, the present invention includes a reservoir filled with a cleaning solution where the ointment applicator is cleaned and stored sterile.

Abstract: Oxygen diffusive wound dressings and methods of manufacturing and use are described herein. The wound dressing may generally provide a ready supply of oxygen to a wound being treated via one or more oxygen conduits which are designed to pass oxygen from ambient air or other oxygen reservoirs into proximity to the wound, and may also provide for exudate removal through transecting channels in fluid communication with both the wound surface and a hydrophilic absorbent material.

Abstract: An in-dwelling port for providing repeated entry to a body during and/or after an operation is described. The port may include an external portion secured to a body outside an incision and a collapsible insertion portion that is inserted through the incision. The collapsible portion collapses when no instrument or lumen is present to permits the body to return to substantially a normal profile around the incision.

Abstract: An injection site for tubular medical connectors, includes a perforable body inserted in a seat of a connector delimited by an annular wall having a retention edge turned in against the outer end of the perforable body. The outer end is formed with a peripheral annular step and with an exposed portion with reduced cross section projecting axially. The peripheral step is defined by an annular groove having a shape complementary to that of the turned-in retention edge of the connector, and the portion with reduced cross section of the perforable body connects up to the groove through an annular surface projecting radially above at least part of the turned-in retention edge and resting against it.

Abstract: An apparatus for electrical stimulation therapy comprising a garment and a plurality of electrode pads associated with the garment, wherein the electrode pads are positionable at selectable locations relative to the garment, such that to correspond to a person's body shape and areas that need electrical stimulation therapy, and wherein contact between the plurality of electrode pads and the person's body is achieved by the person resting on top of the plurality of electrode pads and garment, such that the person's weight assists in creating the contact between the plurality of electrode pads and the person's body.

Abstract: Described is a medical device lead including a lead body having a conductor lumen including an inner surface. The lead also includes a conductor assembly extending through the conductor lumen; the conductor assembly comprising a conductor member and an outer insulative layer; and an electrode coupled to the conductor cable. The outer insulative layer includes a textured external surface that reduces the coefficient of friction between the outer insulative layer and the inner surface of the conductor lumen through which the conductor assembly extends. Methods of forming the conductor assembly are also described.

Abstract: Provided is a perineal probe including a main axis coinciding with the direction of insertion of said probe and a main body, the main body including: a lower surface, an upper surface, opposite said lower surface, a lateral surface, extending between the lower surface and the upper surface and including two opposite main portions substantially parallel to the main axis, at least two lower electrodes, arranged on the lower surface and reciprocally separated along said main axis, at least two lateral electrodes arranged along said main portions of said lateral surface.

Abstract: An instrument holding system for a drive system is provided. The system can include an array holder that defines at least one bore for receipt of an instrument therethrough. The at least one instrument can be adapted for insertion into an anatomy. The array holder can be in communication with the drive system to receive a driving force. The system can include a fixation plate operable to move relative to the array holder such that the fixation plate is in contact with at least a portion of the at least one instrument to couple the at least one instrument to the array holder to enable the at least one instrument to be driven by the driving force into the anatomy.

Abstract: An electrically nonconductive occludent constructed and arranged to forcefully infill a tissue opening so as to effectively prevent transport of electrical current, fluid and bacteria through the tissue opening. A cochlear implant comprising: an elongate electrode carrier member having at least one electrode disposed thereon, wherein the carrier member is configured to traverse a cochleostomy to position the electrodes in the cochlea; and an electrically nonconductive occludent constructed and arranged to circumferentially surround a portion of the carrier member traversing the cochleostomy, and to forcefully infill cochleostomy thereby segregating perilymphatic canals of the cochlea from extracochlear regions.

Abstract: Embodiments of the present invention generally pertain to devices and methods for use in conjunction with implanting a baroreflex therapy system which includes an implantable pulse generator and associated circuitry contained within a hermetically sealed housing, an elongate flexible electrical lead connectable to the housing, and a monopolar electrode structure coupled with the electrical lead. More specifically, the devices and methods of the present invention allow for a mapping procedure to be conducted as part of the implant procedure prior to fully implanting the baroreflex therapy system.

Abstract: A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.

Abstract: The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

Abstract: A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) and peripheral stimulating electrodes and other actuators, in accordance with treatment parameters. The neurological control system may directly or indirectly control a portion of the autonomic nervous system, including the sympathetic and parasympathetic nervous system. Such treatment parameters may be derived from a neural or physiological response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Abstract: Embodiments of the present invention are generally directed to the use of a genetic algorithm for the purpose of providing progressive and adaptive auditory training (rehabilitation) to a recipient of a hearing prosthesis. In general, the genetic algorithm is used to adapt the training process to automatically increase the difficulty of the training based on recipient feedback and performance. That is, the genetic algorithm progressively removes perceivable sounds from the training process so as to generate groups of sounds that are difficult for a recipient to perceive.

Abstract: An RF protection circuit mitigates potentially adverse effects that may otherwise result from electromagnetic interference (e.g., due to MRI scanning of a patient having an implanted medical device). The RF protection circuit may comprise a voltage divider that is deployed across a pair of cardiac electrodes that are coupled to internal circuitry of the implantable medical device. Each leg of the voltage divider may be referenced to a ground of the internal circuit, whereby the different legs are deployed in parallel across different circuits of the internal circuitry. In this way, when an EMI-induced (e.g., MRI-induced) signal appears across the cardiac electrodes, the voltages appearing across these circuits and the currents flowing through these circuits may be reduced. The RF protection circuit may be used in an implantable medical device that employs a relatively low capacitance feedthrough to reduce EMI-induced (e.g., MRI-induced) current flow in a cardiac lead.

Abstract: A rechargeable-battery Implantable Medical Device (IMD) is disclosed including a primary battery which can be used as a back up to power critical loads in the IMD when the rechargeable battery is undervoltage and other non-critical loads are thus decoupled from the rechargeable battery. A rechargeable battery undervoltage detector provides at least one rechargeable battery undervoltage control signal to a power supply selector, which is used to set the power supply for the critical loads either to the rechargeable battery voltage when the rechargeable battery is not undervoltage, or to the primary battery voltage when the rechargeable battery is undervoltage. Circuitry for detecting the rechargeable battery undervoltage condition may be included as part of the critical loads, and so the undervoltage control signal(s) is reliably generated in a manner to additionally decouple the rechargeable battery from the load to prevent further rechargeable battery depletion.

Abstract: A method and system is described for ensuring a state of an active implantable medical device based on the presence and persistence of a magnetic field. The output of a magnetic field sensor is monitored. The active implantable medical device is maintained in a first state, for so long as the presence of a magnetic field is detected by the magnetic field sensor, until a first interval is surpassed. If the first interval is surpassed, then a determination is made as to whether a second interval has been surpassed. If it is determined that the second interval has not been surpassed, then the active implantable medical device is transitioned into a second state. If it is determined that the second interval has been surpassed, then it is ensured that the active implantable medical device is in a predetermined one of the first and second states.

Abstract: A method for treating a human subject having unilateral vocal cord paralysis includes providing a stimulating electrode configured to directly contact a recurrent laryngeal nerve or vagus nerve of the subjects, sensing electrical activity of a synkinetically reinnervated dysfunctional muscle of the subject, generating at least one stimulation parameter, using a processor, based on the sensed electrical activity, and stimulating the recurrent laryngeal nerve or vagus nerve, using the stimulating electrode, based on the at least one stimulation parameter. A system is also provided.

Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.

Abstract: Systems and methods for determining pacing timing intervals based on the temporal relationship between the timing of local and non-local cardiac signal features are described. A device includes a plurality of implantable electrodes electrically coupled to the heart and configured to sense local and non-local cardiac signals. Sense circuitry coupled to first and second electrode pairs senses a local cardiac signal via a first electrode pair and a non-local cardiac signal via a second electrode pair. Detection circuitry is used to detect a feature of the local signal associated with activation of a heart chamber and to detect a feature of the non-local signal associated with activation of the heart chamber. A control processor times delivery of one or more pacing pulses based on a temporal relationship between timing of the local signal feature and timing of the non-local signal feature.

Abstract: An implantable medical device configured to be compatible with the environment inside an MRI machine. The implantable medical device includes a housing constructed of an electrically conductive material and pulse generation circuitry within the housing for generating electrical voltage pulses. The implantable medical device further includes a first conductor that is configured to transmit the electrical voltage pulses from the pulse generation circuitry to a patient's cardiac tissue and a second conductor that is configured to provide an electrically conductive path from the patient's cardiac tissue back to the pulse generation circuitry. The implantable medical device further includes a selectively interruptible electrically conductive path connecting the pulse generation circuitry with the housing.

Abstract: A medical device is provided that includes an input/output, at least one sensor, a memory, a controller and at least one delivery member. The input/output is configured to provide a communication path to and from the medical device. The at least one sensor is used to monitor at least one patient function. The memory is used to store patient specific data from the at least one sensor and operating parameters of the medical device. The controller is used to control operations of the medical device. The controller is in communication with the at least one sensor, the memory and the input/output. The controller is configured to deny device operational change requests received via the input/output based at least in part on the patient specific data sensed by the at least one sensor. The at least one delivery member is under the control of the controller and is configured to provide a therapeutic function of the medical device.

Abstract: Embodiments of the invention are related to managing noise in sensed signals in implantable medical devices, amongst other things. In an embodiment the invention includes a method for processing electrical signals obtained from a patient including gathering a first set of electrical signals using an implantable medical device, filtering to provide a second set of electrical signals, the second set including frequencies above a threshold frequency, and estimating the amount of noise present in the first set of electrical signals based on the magnitude of the second set. In an embodiment, the invention includes a medical device configured to gather a first set of electrical signals, filter the first set to provide a second set of electrical signals including frequencies above a threshold frequency, and estimate the amount of noise present in the first set based on the magnitude of the second set. Other embodiments are also included herein.

Abstract: Systems and methods for positioning implanted devices in a patient are disclosed. A method in accordance with a particular embodiment includes, for each of a plurality of patients, receiving a target location from which to deliver a modulation signal to the patient's spinal cord. The method further includes implanting a signal delivery device within a vertebral foramen of each patient, and positioning an electrical contact carried by the signal delivery device to be within ±5 mm. of the target location, without the use of fluoroscopy. The method can still further include, for each of the plurality of patients, activating the electrical contact to modulate neural activity at the spinal cord. In further particular embodiments, RF signals, ultrasound, magnetic fields, and/or other techniques are used to locate the signal delivery device.

Abstract: This disclosure describes an operational mode of a telemetry module. A device, such as a programming device, operating in accordance with the techniques of this disclosure determines that a transceiver of an implantable medical device is operating in a duty cycled operational mode that includes at least one interval during which the transceiver is powered down interleaved with intervals during which the transceiver is powered up, e.g., for transmitting or receiving communications over an established communication session. The programming device is configured to transmit information during the at least one interval in which the transceiver of the implantable medical device is powered down. Doing so ensures that the channel over which the programmer and implantable medical device communicate will not be usurped by another device.

Abstract: Systems and methods for implantable medical devices and headers are described. In an example, an implantable medical device includes a device container including an electronic module within the device container. A header core includes an electronic connection feature electrically coupled to the electronic module within the device container, the electronic connection feature configured to engage with a lead. In some examples, the header core includes a tag holder configured to locate an identification tag in a selected position with respect to the header core. In some examples, the header core includes an antenna attachment feature configured to locate an antenna in a selected position with respect to the header core. A header shell is disposed around the header core and attached to the device container.

Abstract: An apparatus includes an implantable housing, a header mounted to the implantable housing and including a connector block cavity, and a connector block located within the connector block cavity, the connector block including a plastic housing portion, a coil spring, and a metallic termination member connected to the coil spring and exposed outside the plastic housing portion.

Abstract: Implantable medical device having a feedthrough, a feedthrough and method for making such feedthrough. The feedthrough has a ferrule, an electrically conductive pin, a preform having a preform liquidus temperature, a capacitor, positioned within the ferrule abutting the preform, having a coating having a coating liquidus temperature and being configured to electrically couple with the preform, and an insulative assembly configured, at least in part, to seal against passage of a liquid through the ferrule, and having an insulative assembly liquidus temperature. The coating liquidus temperature is greater than the preform liquidus temperature and the coating liquidus temperature being greater than the insulative assembly liquidus temperature.

Abstract: Implantable medical devices include elongated conductor bodies and related features including an attachment to the medical device at one end and a connector that receives a medical lead at the other end. The connector may have various features such as a modular design whereby the connector is constructed from a series of stacked contact modules. Other features of the connector include electrical contacts that are relatively thin conductors or the order of 0.040 inches or less and that may include radial protrusions to establish contact with the electrical connectors of the lead. Furthermore, electrical contacts may be mounted within the connector in a floating manner so that radial movement of the electrical contact may occur during lead insertion. Additional features include a feedthrough where conductors exposed beyond a housing of the implantable medical device make direct electrical connection to conductors present within the elongated body.

Abstract: A control module for an electrical stimulation system includes an electronic subassembly and a connector assembly coupled to the electronic subassembly. The connector assembly defines a port suitable for receiving a proximal end portion of an electrical stimulation lead. The connector assembly includes connector contacts coupled to the electronic subassembly and open to the port. The connector contacts are suitable for coupling to terminals disposed along the proximal end portion of the electrical stimulation lead when the electrical stimulation lead is received by the port. A covering is conformably disposed over the electronic subassembly and the connector assembly. The covering has an inner surface, an outer surface, and multiple layers.

Abstract: In embodiments, a wearable cardiac defibrillator system includes an energy storage module configured to store a charge. Two electrodes can be configured to be applied to respective locations of a patient. One or more reservoirs can store one or more conductive fluids. Respective fluid deploying mechanisms can be configured to cause the fluids to be released from one or more of the reservoirs, which decreases the impedance at the patient location, and decreases discomfort for the patient. In some embodiments an impedance is sensed between the two electrodes, and the stored charge is delivered when the sensed impedance meets a discharge condition. In some embodiments, different fluids are released for different patient treatments. In some embodiments, fluid release is controlled to be in at least two doses, with an intervening pause.

Abstract: The implantable cardiac treatment system of the present invention is capable of choosing the most appropriate electrode vector to sense within a particular patient. In certain embodiments, the implantable cardiac treatment system determines the most appropriate electrode vector for continuous sensing based on which electrode vector results in the greatest signal amplitude, or some other useful metric such as signal-to-noise ratio (SNR). The electrode vector possessing the highest quality as measured using the metric is then set as the default electrode vector for sensing. Additionally, in certain embodiments of the present invention, a next alternative electrode vector is selected based on being generally orthogonal to the default electrode vector. In yet other embodiments of the present invention, the next alternative electrode vector is selected based on possessing the next highest quality metric after the default electrode vector.

Abstract: Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

Abstract: Systems and methods for providing controllable pulse parameter magnetic stimulation are described. One aspect is directed to a magnetic stimulation system for inducing approximately rectangular electric field pulses in a body organ, comprising an electrical energy storage device, a stimulating coil, and a switching means for electrically coupling said electrical energy storage device to said stimulating coil to produce current pulses in said stimulating coil which generates, in response to the current pulses, magnetic field pulses that can induce approximately rectangular electric field pulses in the body organ.

Abstract: Methods and systems (10, 54, 72) are provided for administering phototherapy to an injured tissue in a living subject by delivering visible or infrared biostimulatory energy to bone marrow at a dose sufficient to cause mesenchymal stem cells to appear in the injured tissue. The energy may be coherent light and can be administered transcutaneously, subcutaneously, or via an intramedullary probe (74). The technique is useful for treating many types of tissue injury, including ischemic cardiac and renal conditions.

Abstract: A device for increasing energy at acupuncture points includes a housing, a light-emitting module, a base, a circuit device, a bending tube and a connection unit. The light-emitting module is disposed in the housing and has a plurality of light-emitting units. The base is a hollow casing. The circuit device includes a circuit board disposed in the base and electrically connected to a first connector. One end of the bending tube is connected to the housing. A transmission line is disposed in the bending tube. One end of the transmission line is electrically connected to the light-emitting module. The other end of the bending tube has a second connector electrically connected to the other end of the transmission line. The other end of the bending tube is removably connected to the base through the connection unit. The first connector and the second connector are selectively electrically connected.

Abstract: It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.

Abstract: The present document describes compounds of Formula I, pharmaceutical compositions comprising the same as well as methods of treating diseases such as a cancer, neurological disease, neurodegenerative disorder, stroke, traumatic brain injury, parasitic infection, inflammation or an autoimmune disease with said compounds.

Abstract: A device for delivery of a radiopharmaceutical and delivery of a pharmaceutical agent are described. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, needle handles, and other devices and methods are also described. Specifically, needle handles having a needle handle body attachable to a portion of a needle, and one or more wings or fins which are grasped by a user are described. The needle handle may be separated from the needle after insertion of the needle into a subject, and/or may provide access to a portion of tubing extending from the needle.

Abstract: A method of using a shielding device with an applicator includes inserting the distal portion of the shielding device to a treatment site of a patient, the shield being made of plastic, imaging the treatment site, planning treatment of the treatment site based on the imaging, setting up the patient for treatment, imaging the treatment site, removing the distal portion of the shielding device from the treatment site, exchanging the shield made of plastic with a shield made of tungsten, inserting the distal portion of the shielding device to the treatment site, the shield being made of tungsten, imaging the treatment site, and performing the treatment.

Abstract: Techniques are generally described for a treatment balloon, and methods and systems effective to detect a position of a beam. The system may include a treatment balloon effective to receive the beam. The treatment balloon may include a shaft and a balloon portion with an open end in communication with the shaft. The balloon portion may be effective to be at least partially filled with a fluid. The treatment balloon may be effective to generate a light wave when the treatment beam is incident on the treatment balloon. A waveguide in the treatment balloon may be effective to receive the light wave. A light detector in optical communication with the waveguide may be effective to detect the light wave. A processor in communication with the light detector may be effective to detect the position of the beam.

Abstract: A system and method for facilitating the healing of a skin ulcer, such as a diabetic ulcer, on a treatment region of a body. Ultrasound waves are transmitted to the treatment region. Interferential electrical stimulation is applied to the treatment region, simultaneously with the ultrasound transmission. The treatment region may be massaged with a massaging device during the treatment session. A gel may be applied onto the treatment region to facilitate the ultrasound transmission and electrical stimulation. A measurement system may be used to obtain accurate measurements of the skin ulcer, to provide a quantitative determination of the healing progression.

Abstract: A method and system uniquely capable of generating thermal bubbles for improved ultrasound imaging and therapy. Several embodiments of the method and system contemplates the use of unfocused, focused, or defocused acoustic energy at variable spatial and/or temporal energy settings, in the range of about 1 kHz-100 MHz, and at variable tissue depths. The unique ability to customize acoustic energy output and target a particular region of interest makes possible highly accurate and precise thermal bubble formation. In an embodiment, the energy is acoustic energy. In other embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other forms, such radio frequency electric currents (including monopolar and bipolar radio-frequency current). In an embodiment, the energy is various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling.

Abstract: Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-MSH analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors.

Abstract: The present invention provides a multi-use firefighting tool. The tool may be used as a stand-alone tool or as a supplement to existing tools. An additional aspect of the present invention is to provide a multi-use tool configured to enable, among other things, forcible entry and valve opening/closing. Further, the tool may be used to supplement a firefighting Halligan tool.

Abstract: Detailed is an aircraft oxygen emergency device including a chemical oxygen generator, an oxygen supply line including a first line section connecting the chemical oxygen generator with a flow regulator unit, and a second line section connecting the flow regulator unit with at least one oxygen mask for supplying oxygen to a mouth or a nose (or both) of a person at a breathing pressure.