Abstract: A portable insulin pump can integrate and display data from a continuous glucose monitor (CGM) to allow a user to more readily determine whether any interaction with the pump is necessary. Data from the CGM can automatically be transmitted to the pump and can be displayed for user analysis or automatically analyzed to present recommendations to the user based on combined data from the CGM and the pump.

Abstract: Disclosed is a disposable tubeless fluid delivery system, comprising a button unit for receiving instructions given by a user through pressing button, a key unit for outputting a selection instruction indicating at least one working mode a fluid reservoir unit for storing a fluid, an indwelling unit for letting through the fluid to a patient, wherein the indwelling unit comprises an indwelling cannula, and a fluid driving unit for delivering the fluid stored in the fluid reservoir unit to the subcutaneous tissue of the patient by the indwelling unit, and a control unit for outputting the delivery instruction to the fluid driving unit and controlling the fluid driving unit to deliver the fluid or suspend fluid delivery. In the present disclosure, a pump base and a wireless control device are integrated to achieve a purpose of small volume, low cost and convenient wearing.

Abstract: Autonomous device (10) comprising a first plate (21) having a first surface (210), a second plate (22) having a second surface (220), and an elastic mechanism (30) for bringing the first (210) and second (220) surfaces closer together and for placing a pouch (40) able to contain a fluid under pressure between said surfaces, the autonomous device (10) being configured in such a way that said first surface (210) and said second surface (220) are able to face one another, and being characterized in that said second surface (220) of the second plate (22) is convex from a viewpoint (35) situated between said first (210) and second (220) surfaces of the first (21) and second (22) plates.

Abstract: A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula.

Abstract: Featured is a vascular access device such as an IV catheter device including a housing, a tubular member and a seal member, and a securing mechanism. The housing includes a proximal and distal portion and a chamber that extends between the proximal and distal portions. The tubular member is coupled to the housing distal portion so it is fluidly coupled to the chamber. The seal member is disposed within the chamber and the securing mechanism secures the seal member distal end to the housing proximal portion so the seal member is sealingly and compressibly retained between a chamber proximal end and the securing mechanism. Such a seal member also is constituted so a portion of the seal member moves axially responsive to an axial force applied to the proximal end.

Abstract: A garment and system for providing intravenous fluid delivery to a patient is provided. The garment is worn adjacent to the skin of the patient and includes a pump unit support portion to support a portable infusion pump and a fluid reservoir support portion to support a fluid reservoir carrying fluid for intravenous delivery to the patient via the infusion pump.

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: Improved needle free injectors comprising of a energy sources, triggering mechanisms, impact members, and drug delivery pistons are disclosed. In one preferred embodiment, the triggering mechanism comprises a spool which seals an energy source comprised of compressed gas and a component for releasing the spool to release the pressurized gas and urge a ram forward to force a drug containing formulation through a drug delivery orifice.

Abstract: Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.

Abstract: The invention relates to a device and a method which allow force to be exerted on a compressible tissue in order to allow a needle to reach at least one of the layers of said tissue that could not have been reached by said needle without having compressed said tissue.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: A medical device connectable to a frontal attachment, the syringe having a forwardly projecting fluid outlet member and a forwardly projecting protective guard extending beyond the outlet member to protect the outlet member from pathogenic contamination by contact prior to connection to the frontal attachment.

Abstract: An assembly for a drug delivery device (1) is provided comprising a first member (10) comprising a main body (14) and an elastically displaceable feature (13) connected to the main body, and an attenuation member (22), wherein the attenuation member mechanically cooperates with the elastically displaceable feature to influence the force which has to be exerted on the elastically displaceable feature to displace the elastically displaceable feature elastically with respect to the main body. Further using an attenuation member (22) in a drug delivery device (22) is proposed to tune the force required to elastically displace an elastically displaceable feature (13) of a first member (10) of the drug delivery device by bringing the attenuation member into mechanical cooperation with the elastically displaceable feature.

Abstract: The mechanism comprises a body (6), a dial (7) that is moved with respect to the body for setting a dose, and an indicator member (11) coupled with the dial. A movement of the dial generates a helical movement of the indicator member, and a movable window (12) is coupled to the indicator member.

Abstract: A piston rod (102) for a drug delivery device (101) is provided, comprising a first thread (103) with a first inner diameter (107) and a second thread (104) with a second inner diameter (108), wherein the first inner diameter (107) of the first thread (103) is smaller than the second inner diameter (108) of the second thread (104), and wherein the first thread (103) comprises a first pitch (105) and the second thread (104) comprises a second pitch (106), wherein the first and the second pitch (105, 106) have the same magnitude. Furthermore, a drug delivery device (101) is provided, the drug delivery device comprising a piston rod (102).

Abstract: Described is an autoinjector (1) comprising a case (2) adapted to hold a medicament container having a needle (4) and the case (2) including a rib (2.6), a needle shroud (7) slidably disposed in the case (2) and translatable between an extended position (EP) relative to the case (2) in which the needle (4) is covered and a retracted position (RP) relative to the case (2) in which the needle (4) is exposed, and a plunger (10) slidably disposed in the case (2). The plunger (10) includes a plunger boss (10.1) adapted to abut the rib (2.6) and the needle shroud (7) when the needle shroud (7) is in the extended position (EP) and disengage the rib (2.6) when the needle shroud (7) is in the retracted position (RP) to allow the plunger (10) to translate axially relative to the case (2).

Abstract: A cap (120) for a drug delivery device (1) having a distal end (121) and a proximal end (122); the cap (120) having an opening at the proximal end and further comprising an outer cap element (130) and an inner cap element (131) being located inside the outer cap element (130), the inner cap element (131) comprising a deformable region (151) and a cap snap means (149); wherein the deformable region (151) of the inner cap element (131) is deformable into a gap (143) between the inner cap element (131) and the outer cap element (130).

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) being arranged as a bistable mechanism with at least one pivoted link (10, 11) having two stable end positions (LEP, UEP) and an instable transitional central position (CP), the drive mechanism (9) further comprising a spring (12) biasing the link (10, 11) out of the transitional central position (CP), wherein at least one trigger unit (17, 21) is arranged for moving the link (10, 11) out of at least one of the stable end positions (LEP, UEP) towards and beyond the transitional central position (CP) against the bias of the spring (12).

Abstract: A needle-equipped syringe reduces an inclination of a needle by reducing an inclination of a core pin when insert molding is performed. The needle-equipped syringe includes a barrel formed using a resin and having a cylindrical body, a nozzle part provided at a distal end of the body, and an opening part provided at a proximal end of the body; and an injection needle held by the nozzle part. The injection needle and the barrel are integrally molded so that an axis of the injection needle is substantially parallel to an axis of the body. The body has a thick part and a thin part located at a proximal end of the body at opposing positions across the axis of the body. At the proximal end of the body, an axis of an inner surface of the body is offset from an axis of an outer surface of the body.

Abstract: The invention relates to an apparatus for ejecting a fluid, having a housing comprising a cartridge retainer (50, 52) configured to hold a fluid containing cartridge (90, 100) and further comprising a cap connection part for removably attaching thereto a cap (18), having a sensor (502,) configured to determine whether the cap (18) is attached to the connection part, and having a control unit configured to measure a quantity being a measure for the radiation load on a cartridge in the cartridge retainer, wherein the control unit is further configured to cause a control step to be performed once the quantity exceeds a predefined threshold value.

Abstract: Systems and methods for delivering medicament using a nebulizer to a subject are controlled and/or powered by a computing device such as a smartphone. Connections may use a USB port, docking connector, and/or headphone jack.

Abstract: In one embodiment, the present disclosure provides a portable nebulizer comprising a housing, a mouthpiece, a reservoir, a disk having multiple pores, and a unit that is configured to cause the disk to vibrate, wherein the vibration of the disk creates a pressure differential that causes a fluid from the reservoir to move through the disk to create an aerosol for delivery. In one embodiment, the mouthpiece may be held in place with at least one metal plate imbedded in the mouthpiece and at least one magnet imbedded in the housing. In one embodiment, the reservoir may have a non-cylindrical shape. In one embodiment, the nebulizer may comprise a battery and a USB port for charging the battery.

Abstract: A system for treating, in particular cleansing, wounds with a fluid jet. The system includes a handpiece with a main body with a front end with an emergence opening for the emergence of the fluid jet. The system furthermore has at least one light-emitting light source, which irradiates aerosols created when cleansing the wound. The system enables wound cleansing with simultaneous decontamination of the aerosols created in the process such that the risk of contamination of the surroundings is reduced and preferably with simultaneously treating the wound with UV light.

Abstract: A dry-powder inhaler comprising a housing comprising at least one air inlet to a first air passage and a second air passage extending from the first air passage and terminating in a mouthpiece; the housing thereby providing a continuous air passage through the at least one air inlet, the first and second air passages, and the mouth piece; a rigid, fixed, powdered-medicament reservoir comprising a base, the reservoir being associated with the first air passage, and together with the first air passage forming a powder chamber; wherein air passing through the powder chamber travels substantially parallel to an upper surface of the reservoir and powdered-medicament positioned on the base in the reservoir, the upper surface of the reservoir having a surface area, and the reservoir having a volume.

Abstract: Disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body and a container bottom, and a predetermined break point that at least partly surrounds the container bottom, characterised by a collar that surrounds the predetermined break point at its outside and extends the container body over and beyond the container bottom.

Abstract: A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.

Abstract: The present invention provides a drug delivery system that includes a housing configured to contain one or more dispensers. Each dispenser includes an activation mechanism, a nozzle configured to direct the medicament to a predetermined area in the nasal passageway. The nozzles may be configured to create a spray pattern that is about 50-degrees to direct the delivery of a medicament to the sphenopalatine ganglion.

Abstract: An intranasal atomizer drug chamber housing comprises an atomizable liquid, an atomizer chamber; a slidable plunger; an atomizer in the atomizer chamber and a spring to drive the plunger upon release from a compressed position. The intranasal atomizer may additionally comprise: a drug chamber veil attached to outlet end of the atomizer, and shaped to fit in a user's nostril. A trigger housing comprising a trigger button and a trigger mechanism may be attached to the drug chamber housing. The trigger mechanism retains the spring in a compressed position, and releases the spring to drive the plunger upon activation of the trigger button. A safety cap fits over the outlet end of the drug chamber housing and has a flexible arm to insert within the trigger mechanism to prevent the release of the spring. A method of providing an atomisable drug or medicament using the intranasal atomizer is also disclosed.

Abstract: Breathing assistance apparatus includes a gases supply unit adapted to, in use, deliver a stream of pressurised gases from an outlet. The gases supply unit is adapted to vary the pressure of the stream of pressurised gases. A supply path includes a flexible self-supporting gases transportation pathway having a first end connected to the outlet so that the gases transportation pathway receives the stream of gases and conveys the gases to a patient. A patient interface is connected to the second end of the gases transportation pathway receives a stream of gases. At least one sensor measures at least one information parameter of the supply path. A control system associated with the gases supply unit receives the information parameter. The control system contains reference data, and compares the received data to reference data, and determines a supply path based on the comparison.

Abstract: The present invention relates to an adapter for use with an anesthesia mask or other mask used to administer inhalational gas(es) to a patient. The adapter is structured for providing an interactive video game to a patient before and/or while gas is being administered. The invention further comprises a sensor, and in most embodiments, will be coupled directly or indirectly to a portion of the mask. The sensor or sensor module comprising a microphone and/or other structure for receiving control commands from the patient or user, and a computing device in a communicative relationship with the sensor structured for presentation of interactive media to the user. The sensor module is configured to detect control commands from a patient and relay it as an input signal to the computing device. The computing device is structured to correspondingly alter the interactive media according to the control commands given by a user.

Abstract: The objective of the present invention is to allow a hydrogen gas which has a gas mixture concentration of over 4% to be breathed in safely, and to reduce the amount of use of hydrogen gas, which is dangerous, and increase utilization efficiency of the hydrogen gas. The objective of the present invention is also to impart an auxiliary role to a device in the treatment of patients suffering from viral or bacterial pneumonia using hydrogen gas. A hydrogen gas mixture breathing device and a related system employ an intrinsically safe structure and a safety system which prevent occurrence of explosions. A detonation flame arrester, etc. are installed where necessary to provide against electrostatic explosions, etc., and to protect a user's lung function from explosion flames. In addition, a device for supplying aerosol in which a hydroxyl radical is dissolved is also installed, and operating time and volume are appropriately adjusted under the supervision of a professional.

Abstract: For use in premature babies and infants, in particular for administering surfactant to the lungs, the inhalation therapy device described herein comprises an aerosol generating device 1, a respiratory air flow generating means 3 and a nebulising chamber 5 into which the generated liquid droplets 2 and the respiratory air flow 4 are supplied. The nebulising chamber 5 comprises a tapering area 52 which ends in a tubular intubation means 6. The intubation means 6 is designed such that the intubation end 6b can be positioned in such a manner that the liquid droplet/respiratory air mixture conveyed via the intubation means is released behind those areas of the respiratory tract that filter out to a great extent the liquid droplets from the mixture.

Abstract: A flow generator for use in respiratory therapy can be constructed with a housing. A support fixation arrangement can be fixed to the housing. The support fixation arrangement can have a tab having an aperture that may be fitted over a hook extending from a support structure. The tab can be fixed to the housing such that it is manually liftable or pivotable about a plane.

Abstract: A ventilator control signaling method includes recording an electromyogram signal of values following one another in time and transforming the electromyogram signal into an evaluation signal by applying an evaluation function. An evaluation signal value is assigned to a signal value of the electromyogram signal in the transformation. The evaluation function is determined by a main parameter set that defines which signal value of the evaluation signal is assigned to a particular signal value of the electromyogram signal when the evaluation function is applied in the transformation. A signal value height of the evaluation signal indicates whether the electromyogram signal corresponds to a first state or a second state. A control signal is generated from signal values and is set to switch a ventilator to an inhalation or an exhalation operating mode depending on the state of the evaluation signal. A ventilator is configured to perform the method.

Abstract: A blower comprises a housing, an inlet to receive air, an outlet to deliver a flow of air and a deformable member configured to pump a chamber. The deformable member may be configurable to a first configuration and a second configuration, for example by electrical energy that may be applied as current or voltage. The blower may comprise a plurality of chambers, wherein each chamber may be compressed out of phase with each other, for example such that the flow rate of the generated air flow may not fluctuate as much. In other forms, the blower may comprise a plurality of chambers that vary in size.

Abstract: A cleaning apparatus including an elongate tubular member utilized by extending into an artificial airway such as, but not limited to, an endotracheal tube which may be used in a method and system for expediting a patient's weaning from ventilator support. A cleaning assembly provided at a distal end of the elongate tubular member radially expands to engage the interior wall of the endotracheal tube, for cleaning thereof by an outer periphery, achieving an effective cleaning engagement. A fluid impervious bladder portion provides an effective seal preventing fluid seepage during cleaning withdrawal. Further, a ventilator coupling connects to the endotracheal tube, a first inlet port couples to a ventilator assembly to supply air to a patient, and a second inlet port receives the elongate tubular member there through into the endotracheal tube.

Abstract: A patient respiratory interface for use in an aerosol delivery system is disclosed. The interface may provide a mechanism for introducing an aerosolized medicament to infants without the need for invasive intubation when treating issues in infants such as infant respiratory distress syndrome. The interface may include an outer body formed in the shape of a pacifier where the insertion portion of the pacifier may be hollow and have an opening to guide a catheter or other tubing that may be passed through a flange and the insertion portion of the interface. The catheter may be recessed from or extend slightly out of the tip of the insertion portion so that a flow of nebulized medicament may be delivered to the patient's oropharynx in aerosol form.

Abstract: A nasal cannula for use in a system for providing a flow of respiratory gases to a user is described. The nasal cannula comprises a body made from a pliable material. The body has an inlet and at least one nasal prong fluidly connected to the inlet. In use a conduit providing a flow of gases to the cannula is connected to the inlet, and the nasal prong is inserted into a user's nostril. The cannula is arranged to direct the flow of gases from the nasal prong towards the front wall of the user's nasal passage within the user's nose.

Abstract: Embodiments of the present invention relate to a breathing mask for alleviating conditions causing sleep apnea and avoiding onset claustrophobia in a patient often caused by a breathing mask. In one embodiment of the present invention, a breathing mask comprises an overhead gear assembly comprising an overhead receptor and a hose attachment connected to the overhead receptor, and a patient interface coupled to a connector tubing and/or valve of the overhead gear assembly, wherein the hose attachment is positioned outside of a line of sight of a user, when the breathing mask is utilized by the user.

Abstract: A connection assembly for a respiratory therapy system, comprising: an outlet assembly, said outlet assembly including an outlet housing and a swivelling disc located on said outlet housing, said outlet housing and said swivelling disc defining, at least in part, a recess; an outlet connector located at an end of a tube portion, said outlet connector including an electrical connector; and a cable having a first end to connect to the electrical connector and a second end to connect to at least one electrical component of the respiratory therapy system, said cable having a slack portion, wherein said outlet connector and said swivelling disc are rotatable in unison between a first position and a second position, and wherein the slack portion of the cable extends from the recess and wraps around the swivelling disc as the swivelling disc is rotated from the first position to the second position.

Abstract: A compressible respiratory gas hose system interconnects a breathing gas source 101 and a patient interface device. The hose system has an open position when a breathing gas flow from the gas source is conducted to the patient interface device and a closed position when the gas flow is blocked. The aforesaid hose system comprises: (a) a first connector connectable to the gas source; (b) a second connector connectable to the patient interface device; (c) a resilient helical support member, mechanically interconnecting the first and second connectors; (d) a flexible envelope accommodating the support member and providing gas interconnection between the first and second connectors; and (e) a rod reconfiguring the support member from the relaxed long position to the compressed storage position and vice versa.

Abstract: A float retention arrangement and related methods for a humidification chamber that includes at least one float that operates an inlet valve that controls a flow of water through a water inlet opening of the humidification chamber. A cover of the humidification chamber defines an interior space, at least one gas port and a float retention opening. A component forms at least a portion of a water supply conduit for supplying water from a water source to the water inlet opening. The component is insertable into the float retention opening and is positionable to contact and retain the at least one float in a non-use position. In some configurations, the component can be a water spike.

Abstract: A balloon catheter comprising a catheter (3) and a balloon (7) located at a distal end (5) of the catheter (3). A plurality of measuring electrodes (12) formed on a primary substrate (17) extend around the catheter (3) within the balloon (7). The primary substrate (17) is formed by a portion of a flexible resilient membrane (25) which also forms a secondary substrate (19). The measuring electrodes (12) are formed on the primary substrate (17) by first electrically conductive tracks (27) and second electrically conductive tracks (28) which are electrically connected to the first electrically conductive tracks (27) are simultaneously formed on the secondary substrate (19). The membrane (25) is coiled to form a roll, and the primary substrate (17) is also coiled around the rolled secondary substrate (19).

Abstract: A catheter has an entrance opening defined by the first end of a catheter body and non-smooth inner surface. The entrance opening intersects a longitudinal axis extending longitudinally through the center of a lumen adapted to drain urine from a bladder. The non-smooth inner surface can have dimples, channels, or grooves, all of which decrease frictional fluid forces against the inner surface as the urine drains. The catheter is free of any eyelets formed in the side wall of the catheter body. The catheter is further free from any hemispheric tip located at one end.

Abstract: An apparatus and method for the treatment of intravascular medical conditions is provided. The device comprising a handle assembly, an expandable portion defined by a plurality of struts oriented along a longitudinal axis and a tip member affixed to a distal end of the struts. The struts are moveable between a collapsed and an expanded position. A catheter tube extends from the handle assembly to the expandable portion. An elongate member is disposed within the catheter tube and is in communication with the handle assembly and the tip member.

Abstract: A method of dissecting tissue includes inserting a magnetized catheter into a urethra; magnetically pushing a tool away from the urethra with the magnetized catheter; and dissecting tissue posterior of the urethra with the tool.

Abstract: An introducer sheath, which is formed from a tubular member provided with a hollow portion through which an elongated body is freely insertable, and which includes a distal portion and a main body portion, wherein the inner diameter of the distal portion is formed to become gradually smaller toward the distal side, and on the inner surface of the distal portion, there is provided a hydrophobic coating having a friction coefficient lower than the friction coefficient of the tubular member.

Abstract: Three groups of guidewire embodiments are described with particularly suitable structures for navigating circuitous vessels, especially blood vessels of the brain. Some of the guidewires have a hyperbolic taper that provides desired flexibility. In some embodiments, an integrated guide structure provides for extension in the blood vessel of a corewire to provide for extended reach of the guidewire. In further embodiments, the guidewire has a flexible tip that can be guided directly by the flow in the vessel.