Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Abstract: Endoglin has been identified to play a functional role as a regulator of TGF?1 signaling, particular in TGF?1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity. The present invention also features methods of treating autoimmune diseases, inflammatory diseases, organ transplantation, and conditions association with oxidative stress related to TGF?1-mediated calcineurin expression and reactive oxygen species (ROS) production by administering a composition that inhibits endoglin activity. The present invention also features methods of treating fibrotic diseases by administering a composition that inhibits endoglin activity.

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

Abstract: Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin molecules, such as IgG antibodies, as well as antibody fragments, such as single-domain VH antibodies or single chain variable fragments (scFv). Further provided are compositions including the antibodies that bind GPC3 or HS chains on GPC3, nucleic acid molecules encoding these antibodies, expression vectors comprising the nucleic acids, and isolated host cells that express the nucleic acids. Methods of treating cancer and/or inhibiting tumor growth or metastasis are also provided. Further provided are methods of detecting cancer in a subject and confirming a diagnosis of cancer in a subject.

Abstract: The present disclosure concerns monoclonal antibodies directed to the pro-domain of ADAM 12 and their use in the treatment of cancer.

Abstract: The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the ?-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.

Abstract: Provided are ROR1 binding molecules, including anti-ROR1 antibodies, including antibody fragments such as variable heavy chain (VH) regions, single-chain fragments, and chimeric receptors including the antibodies, such as chimeric antigen receptors (CARs). In some embodiments, the antibodies specifically bind to ROR1. Among the antibodies are human antibodies, including those that compete for binding to ROR1 with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the chimeric receptors, and uses of the binding molecules and cells adoptive cell therapy.

Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: The present disclosure provides various molecular constructs having a targeting element and/or an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: This disclosure relates to a method for preparing super absorbent polymer. The method for preparing super absorbent polymer according to the present invention comprises the steps of performing photopolymerization of a monomer composition comprising water soluble ethylene unsaturated monomers, a thermal polymerization initiator and a photopolymerization initiator at a temperature of 30 to 55° C.; performing a thermal polymerization and a photopolymerization at a temperature of 55 to 120° C. to form a hydrogel polymer; and drying the hydrogel polymer. According to the present invention, by comprising two polymerization steps including performing photopolymerization at low temperature and then performing thermal polymerization or photopolymerization at high temperature, super absorbent polymer having improved physical properties may be obtained.

Abstract: Disclosed is a method of preparing a modified conjugated diene-based polymer, including (a) polymerizing a conjugated diene monomer, or a conjugated diene monomer and an aromatic vinyl monomer, using the compound represented by Chemical Formula 1 in the presence of a solvent, thus obtaining an active polymer having a metal end, and (b) modifying the active polymer with the compound represented by Chemical Formula 2.

Abstract: Disclosed are a modified conjugated diene-based polymer represented by Chemical Formula 1, a method of preparing the same, and a rubber composition including the same.

Abstract: The invention relates to a metallocene complex according to formula (1) wherein M is a metal selected from lanthanides or transition metals from group 3, 4, 5 or 6 of the Periodic System of the Elements, Q is an anionic ligand to M, k is the number of Q groups and equals the valence of M minus 2, Z1, Z2, Z3 and Z4 are identical or different and can be chosen from the group consisting of hydrogen and a hydrocarbon radical with 1-20 carbon atoms, and adjacent substituents Z can form a ring system together with the carbon atoms of the Cp ring to which they are bound.

Abstract: The present technology relates to a method of introducing a supported antistatic compound that does not comprise a transition-metal-based catalyst component for use in an olefin polymerization reactor. In some embodiments, the methods disclosed herein avoid the formation of polymer agglomerates in the reactor and minimize potentially negative effects on catalyst yield.

Abstract: The present technology relates to a solid catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of the general formula (I): where R1 is selected from C1-C15 hydrocarbon groups, the R2 groups are equal to or different from each other, are hydrogen, or the R1 groups can be fused together to form one or more cycles and A is a bivalent bridging group. The catalyst components of the present disclosure exhibit high activity and stereospecificity in the polymerization of olefins.

Abstract: The present invention relates to a preparation method of a polypropylene and a polypropylene obtained therefrom. More specifically, it relates to a method of preparing a polypropylene by using a catalyst that includes a novel metallocene compound having an excellent polymerization activity, and a polypropylene obtained by the method. According to the present invention, since the polypropylene is prepared by polymerizing propylene by using a novel metallocene compound having an excellent polymerization activity and hydrogen reactivity, the properties of the polypropylene can be easily controlled and the polypropylene having excellent mechanical properties can be obtained.

Abstract: Disclosed are an apparatus and a method for removing halogens generated during the preparation of polybutene, which are capable of improving the utilization of polybutene and light polymers by removing halogen components contained in the polybutene and the light polymers. The method for removing halogens generated during the preparation of polybutene comprises the steps of: preparing a reaction product by supplying a catalyst and a reaction raw material to a reactor and polymerizing; removing a catalyst component from the reaction product and neutralizing; separating the reaction product into an organic compound and impurities comprising the catalyst component; heating the organic compound to distill an unreacted material; and removing a halogen component in a remaining polymerization mixture after the distillation using a halogen removing catalyst, or removing a halogen component in polybutene and light polymers obtained from the polymerization mixture using the halogen removing catalyst.

Abstract: The invention provides a redox flow battery comprising a microporous or nanoporous size-exclusion membrane, wherein one cell of the battery contains a redox-active polymer dissolved in the non-aqueous solvent or a redox-active colloidal particle dispersed in the non-aqueous solvent. The redox flow battery provides enhanced ionic conductivity across the electrolyte separator and reduced redox-active species crossover, thereby improving the performance and enabling widespread utilization. Redox active poly(vinylbenzyl ethylviologen) (RAPs) and redox active colloidal particles (RACs) were prepared and were found to be highly effective redox species. Controlled potential bulk electrolysis indicates that 94-99% of the nominal charge on different RAPs is accessible and the electrolysis products are stable upon cycling. The high concentration attainable (>2.

Abstract: Modified water soluble polymer crosslinking agents can be used by themselves or in combination with conventional crosslinking agents, other crosslinkable base polymers, and/or hardeners. The dried composition is redispersible in water prior to crosslinking, but is stable to water after crosslinking, also offering improved stain resistance.

Abstract: A process for polymerizing propylene in the presence of a polymerization catalyst by polymerizing propylene with a comonomer selected from the group of ethylene and C4-C10 alpha-olefins in two polymerization stages where the comonomer is present in at least one of the polymerization stages. The first polymerization stage is conducted in a loop reactor and the second polymerization stage in a gas phase reactor. The polymer produced in first polymerization stage has a higher melt flow rate and a lower content of comonomer units than the final polymer mixture. The process can be operated with a high throughput and catalyst productivity. The polymers are useful for making films.

Abstract: To provide a perfluoroelastomer, which is excellent in low temperature properties, which does not lose value as a rubber and which is free from a decrease of the productivity, a perfluoroelastomer composition, a crosslinked rubber product, and a method for producing a perfluoroelastomer. A perfluoroelastomer comprising structural units (a) derived from tetrafluoroethylene, structural units (b) derived from a perfluoroalkyl vinyl ether represented by the formula (1) (such as perfluoromethyl vinyl ether) and structural units (c) derived from a perfluorooxaalkyl vinyl ether represented by the formula (2) (such as CF2?CFOCF2CF2OCF2CF2OCF2CF3).

Abstract: The present invention generally relates to methods for resolving water and oil emulsions in the produced fluid of an oil production system comprising adding a reverse emulsion breaker to the produced fluid of the crude oil production system in an amount effective for resolving an oil-in-water emulsion. In particular, these methods for resolving an oil-in-water emulsion can be used in separation processes where the oil and solids in the produced fluid are separated from the produced water in the produced fluid.

Abstract: The present invention relates to a super absorbent polymer. The super absorbent polymer according to the present invention includes surface crosslinked polymer particles prepared by surface crosslinking particles of a base resin, wherein the base resin is polymerized from water-soluble ethylene-based unsaturated monomers, and a water-soluble component, in which the water-soluble component is present in an amount of 5% by weight or less based on the total weight of the super absorbent polymer, when measured after free swelling the super absorbent polymer in a 0.9% NaCl solution for 1 hour, and the super absorbent polymer has a permeability of 50 seconds or shorter. According to the present invention, provided is a super absorbent polymer having excellent liquid permeability even when swollen without a reduction in centrifuge retention capacity or absorbency under load while having improved permeability.

Abstract: A method of preparing a plant oil based polymer comprising heating a plant oil in the presence of a bismaleimide crosslinker in the substantial absence of a solvent at a temperature at or above the melting temperature of the bismaleimide crosslinker, where the bismaleimide crosslinker is defined by the formula where R1 is a divalent organic group.

Abstract: Provided are a vinyl ether polymer which can exert temperature responsiveness even in the case of being supported on a highly hydrophobic fibrous substrate, an agent for controlling hydrophilicity and hydrophobicity containing the polymer, a method for controlling hydrophilicity and the hydrophobicity using the polymer, and a polymer-substrate composite having the polymer supported on a substrate.

Abstract: The present invention relates to a process for producing emulsion polymer particles having a core-shell structure, wherein the weight ratio of the shells is within specific limits, and also to their use in paints, paper coatings, foams and cosmetic compositions.

Abstract: A block copolymer, a method for preparing a block copolymer, a resin composition, and a film are provided. The block copolymer can be useful in inhibiting complete separation of the hard segment even under a severe high-temperature condition by increasing the chemical cross-linking density around the hard segment without causing an increase in glass transition temperature of the hard segment, thereby maintaining high-temperature durability.

Abstract: A process for forming a conventional flexible polyurethane foam includes providing a polyol component including a PIPA polyol that is a dispersion having a solids content from 10% to 75 wt %, based on a total weight of the PIPA polyol, providing an isocyanate component that includes at least one polyisocyanate, providing an additive component that includes a catalyst, and forming a reaction mixture including the polyol component, the isocyanate component, and the additive component to form a flexible polyurethane foam with a resiliency value below 45%. The reaction mixture has an isocyanate index from 90 to 150.

Abstract: Thixotropic polyol dispersions are described. The dispersions contain a dispersed phase of polyurethane-isocyanurate particles. They can be made by reacting a low equivalent weight polyol with a polyisocyanate in the presence of an isocyanate trimerization catalyst while dispersed in a base polyol. These polyol dispersions are useful as the resin component of curable systems such as formulated coatings, sealants or adhesives.

Abstract: The invention relates to multi-component epoxy resin compositions, comprising the following components: a) at least one epoxy resin component containing a1) at least one epoxy resin and a2) at least one compound of the general formula (I), wherein R1 and R2 independently from one another stand for hydrogen, C1-C6-alkyl, C1 -C4-alkoxy-C1-C4-alkyl, C5-C6-cycloalkyl, phenyl, phenyl-C1-C4-alkyl, C2-C6-alkenyl, or C2-C6-alkynyl, or R1 and R2 jointly stand for a C3-C11 alkylene group; R3 and R4 independently from one another stand for hydrogen, C1-C6-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C5-C6-cycloalkyl, phenyl, phenyl-C1-C4-alkyl, C2-C6-alkenyl, or C2-C6-alkynyl, or R3 and R4 jointly stand for a C4-C6 alkylene group; b) at least one hardener component containing b1) at least one amine curing agent, wherein the epoxy resin component (a) and/or the hardener component (b) contain at least one additional constituent part c1), which is selected from aliphatic polyether polyols and aliphatic polyetheramine polyols.

Abstract: The present invention relates to new carboxy-functional polyester and diester derivatives preparable by ring-opening reaction of (A) at least one anhydride of the formula (I) where R1=H, C1 to C24 alkyl, or C2 to C24 alkenyl with (B) at least one hydroxy-functional component, where (B1) the polyester derivatives are prepared using at least one linear hydroxy-functional polyester prepared using 7 to 95 mol %, based on the total amount of the monomers used in preparing the polyester (B1), of at least one difunctional monomer (b1) with aliphatic groups with 12 to 70 carbon atoms between the functional groups, and (B2) the diester derivatives are prepared using at least one dihydroxy-functional component which has an aliphatic group with 12 to 70 carbon atoms between the hydroxyl groups. The present invention further relates to aqueous compositions comprising at least one such polyester derivative and/or diester derivative, and water.

Abstract: Polyester polyols, processes for making them, and applications for the polyols are disclosed. In some aspects, the polyols comprise recurring units from a thermoplastic polyester or an aromatic polyacid source, a glycol, and a lignin, tannin, or mixture thereof. Optionally, the polyols incorporate recurring units of a hydrophobe. The polyols are made in one or multiple steps; in some aspects, the thermoplastic polyester or aromatic polyacid source and the glycol are reacted first, followed by reaction with the lignin, tannin, or mixture thereof. High-recycle-content polyols having desirable properties and attributes for formulating polyurethane products, including two-component polyurethane coatings, can be made. The polyols provide a sustainable alternative to bio- or petrochemical-based polyols.

Abstract: Polyetheretherketone (PEEK) may be prepared by polycondensation of a single monomer (4-fluoro-4?-(4-hydroxyphenoxy) benzophenone) in diphenylsulphone (DPS) solvent and in the presence of sodium carbonate and potassium carbonate. The process can be used to produce high quality, relatively light coloured polymers having a lower Tm than those produced using a standard PEEK process.

Abstract: Amine functional polyamides comprise amine and ammonium groups along the polymer chain. Amine functional polyamides can be used as pharmaceutical agents and in pharmaceutical compositions. The amine functional polyamides are particularly useful in the treatment or prevention of mucositis and infection, specifically oral mucositis, surgical site infection, and lung infection associated with cystic fibrosis.

Abstract: A metal-organic framework (MOF) polymer for solid-phase microextraction (SPME) includes an MOF including metal ions building units coordinating polytopic organic linkers; and a polymer coordinatively bonding to the MOF, wherein the polymer is composed of one or more vinyl monomers and a cross-linker those are polymerized in the presence of a radical initiator. A method for preparing a stationary phase for SPME is also provided.

Abstract: Methods of preparing a polyaniline homopolymer or copolymer comprising at least one carboxylic acid group, and homopolymers or copolymers arising therefrom, the methods comprising: preparing a solution of a polyaniline precursor having at least one aromatic amine group and at least one carboxylic acid group (eg. 2-aminobenzoic acid, 3-aminobenzoic acid or 4-aminobenzoic acid) in a solvent selected from aqueous methanesulfonic acid or aqueous ammonia and optionally one or more additional polyaniline precursors (such as aniline); and oxidatively polymerising the polyaniline precursor or precursors.

Abstract: Disclosed are a curable resin, a spacer composition, a filter, methods of preparing the same, a filter and a method of preparing the same, and a display device. The curable resin includes 1 part by weight of dianhydride, 0.6 to 2 parts by weight of diamine, and 0.8 to 3 parts by weight of vinyl monomer.

Abstract: The present invention relates to compositions comprising a binder which comprises at least one alkoxy-functional polysiloxane, and at least one crosslinking catalyst, the crosslinking catalyst representing a silicon-containing guanidine compound, and also, optionally, an alkoxysilane as crosslinker.

Abstract: Provided is a curable resin composition which exhibits excellent curability and is good in storage stability. The curable resin composition comprises (a) a polymer having a hydrolyzable silyl group, (b) an acid catalyst, and (c) an onium salt represented by the following general formula (1): C+A???(1) wherein C+ is an onium cation, and A? is a hydrogen sulfate anion, a hydrogen sulfite anion, a sulfonate anion represented by R1SO3? wherein R1 represents an alkyl group, perfluoroalkyl group, cycloalkyl group, vinyl group, aryl group, perfluoroaryl group, aralkyl group or halogen atom; or a bis(substituted sulfonyl)imide anion represented by (R2SO2)2N? wherein R2 represents an alkyl group, perfluoroalkyl group, or aryl group; tetrafluoroborate anion, or hexafluorophosphate anion.

Abstract: The invention relates to polysiloxanes with quaternized heterocyclic groups in the side chain, to the use and production thereof, in particular for finishing textiles and for hydrophobing objects.

Abstract: Polyimides containing a backbone with at least one nanoparticle component and made from oligomers having endcaps that are difunctional or a mix of di- and monofunctionality are provided. The endcaps may be nadic or phenylethynyl. The backbone may be wholly inorganic or made from a mixture of inorganic and organic groups. The oligomers may be created in-situ using standard polymerization of monomeric reactants chemistry using a solvent or may be provided as a pre-imidized compound that may be either a solid or liquid. It is believed that the nanoparticle component of the polymer backbone provides superior thermo-oxidative stability verses unmodified organic backbones. It is further believed that providing difunctional or a mixture of di- and monofunctional endcaps allows for increased crosslinking to provide improved strength and stiffness verses wholly monofunctional endcapped oligomers for polyimides. The nanoparticle is part of the backbone of the polymer and not solely a pendant group.

Abstract: The present invention is: a curable composition comprising a component (A) and a component (B) in a mass ratio (component (A):component (B)) of 100:0.1 to 100:50; a cured product obtained by curing the curable composition; and a method for using the curable composition as an optical device-securing adhesive or an optical device sealing material.

Abstract: The present disclosure provides hydrosilylation curable compositions comprising resin linear organosiloxane block copolymers comprising, among other things, from about 0.5 to about 5 mole % C1 to C30 hydrocarbyl group comprising at least one aliphatic unsaturated bond. Such hydrosilylation curable resin-linear organosiloxane block copolymers have significantly faster cure speed, relative to their condensation curable counterparts. A faster cure speed can be important for encapsulating electronic devices, such as light-emitting diode (LED) chip devices, particularly devices having tall structures.

Abstract: Process for producing polyarylene ether beads from a polyarylene ether solution, comprising the steps of i) dividing the polyarylene ether solution into droplets, ii) transferring the droplets into a precipitation bath to form polyarylene ether beads in the precipitation bath which (A) comprises at least one aprotic solvent (component (1)) and at least one protic solvent (component (2)), (B) has a temperature of 0° C. to Tc, where the critical temperature Tc in [° C.] can be determined by the numerical equation Tc=(77?c)/0.58 in which c is the concentration of component (1) in the precipitation bath in [% by weight] and (C) has component (1) in concentrations of 5% by weight to cc, where the critical concentration cc in [% by weight] can be determined by the numerical equation cc=77?0.58*T in which T is the temperature in the precipitation bath in [° C.], where the percentages by weight are each based on the sum of the percentages by weight of component (1) and of component (2) in the precipitation bath.

Abstract: The invention refers to a Process for preparing a bio-resorbable polyester the form of a powder with a bulk density of 0.3 g/ml or more, a tapped density of 0.4 g/ml or more and a specific surface area of 2.0 m2/g or less comprising the steps a. dissolving a bio-resorbable polyester in a first solvent to form a polymer solution, b. contacting the polymer solution with a second solvent which is a non-solvent for the bioresorbable polyester and which is mainly water to result the precipitation of the bio-resorbable polyester in the form of a wet polymer mass, c. pre-drying the wet polymer mass at a temperature below the TgO of the bio-resorbable polyester, d. comminuting the pre-dried polymer mass to polymer particles with a size below 10 mm, e. drying the comminuted polymer particles below the TgO of the bio-resorbable polyester to a residual water content of 1% or less by weight/weight, f.

Abstract: In the step (I), the period (minute(s)) for dispersing the carbon black species A showing a nitrogen adsorption specific surface area (N2SA-(A)value) of 130 m2/g or less in the dispersing solvent and that minute(s)) for dispersing the carbon black species B showing an N2SA-(B) value lower than the N2SA-(A) value by 25 m2/g or more in the dispersing solvent toy ?(A) and ?(B), respectively, and further representing the rotation number (rpm) of a rotor of a dispersing machine used in the dispersing when the carbon black species A is dispersed, and that (rpm) of a rotor of a dispersing machine used in the dispersing when the carbon black species B is dispersed by ?(A) and ?(B), respectively, the following expression is satisfied: 1.1?(B)×?(B)??(A)×?(A)?1.

Abstract: A pigment masterbatch, having a) 30-95 wt % of at least one pigment, b) 2-30 wt % of a compound A according to formula I, c) 1.0-10 wt % of a compound B according to formula C2H4(NHC(O)R3)2, and d) 1.5-20 wt % of a compound C, which contains at least one polyethyleneglycol moiety and at least one fatty acid moiety coupled to the polyethyleneglycol moiety, e) 0-50 wt % of a polymeric compound D, wherein R1 is an alkyl group comprising 1-20 carbon atoms and Z is hydrogen or a group according to the formula C(O)R2, wherein R2 is an alkyl group comprising 1-20 carbon atoms, and wherein R3 is a fatty acid moiety comprising 10-30 carbon atoms, and wherein the wt % are relative to the total weight of the pigment masterbatch.

Abstract: A method comprising at least (a) a step of preparing a silane master batch by melt-kneading, to 100 parts by mass of a base resin (RB) containing a non-aromatic organic oil and ethylene rubber, an organic peroxide of from 0.01 to 0.6 parts by mass, an inorganic filler of from 10 to 400 parts by mass, and a silane coupling agent of from 1 to 15.0 parts by mass, at a temperature equal to or higher than the decomposition temperature of the organic peroxide; a heat-resistant silane crosslinked resin molded body and a heat-resistant silane crosslinkable resin composition prepared by the method, and a silane master batch and a heat-resistant product.

Abstract: A process is provided for overmolding an insert or substrate with non-oriented thermoplastic fibers present in an amount that allows them to thermally bond in the presence of non-oriented filler fibers. The thermoplastic fiber fusion retains the filler fibers within the insert upon cooling. The filler fibers are selected to modify the properties of the insert and an overmolded article formed with the insert therein. Such overmolded articles are used in applications including vehicle components such as automotive interior light bases, posts, undercar components, cross members, chassis components, and frame components; architectural components such as home door interiors, sound damping panels, and weather resistant wood replacement. Articles formed with the inventive process yield weight reductions compared to conventional insert overmoldings, along with low scrap generation, process flexibility with respect to part shape and fiber material.