Abstract: A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen in which waste fluid flows proximally therethrough during operation of the catheter pump. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate, the rotor including a longitudinal rotor lumen therethrough. The motor assembly can also comprise a stator assembly disposed about the rotor. During operation of the catheter pump, the waste fluid flows from the lumen into the chamber such that at least a portion of the waste fluid flows proximally through the longitudinal rotor lumen.

Abstract: A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen therethrough. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate. The motor assembly can also comprise a stator assembly disposed about the rotor. The motor assembly can also include a heat exchanger disposed about the stator assembly, the heat exchanger may be configured to direct heat radially outward away from the stator assembly, the rotor, and the chamber.

Abstract: A cardiac support system comprising an intake region for the intake of blood, an outlet region for discharging the intake blood, a pump arrangement for conveying the blood from the intake region to the outlet region, a pump-aorta connection, and a suction connection from the intake region to the pump, parts of the function of the heart being taken on by said cardiac support system, and a cardiac support method having the steps of taking in blood from within the left half of the heart, pumping, and transferring aspirated blood into the aorta with the cardiac support system.

Abstract: A method for controlling or regulating the pressure, which prevails within a heating bag of a tubing system used for the treatment, wherein the method encompasses the steps: Determining the pressure; comparing the determined pressure with a reference pressure or detecting its state with respect to a reference pressure range and changing a treatment parameter of the treatment of the patient or suggesting a correction of the treatment parameter in case the determined pressure is below or above, respectively, the reference pressure or outside the reference pressure range.

Abstract: A dialysis system includes an on-line dialysate generator, a first dialysate pump in fluid communication with the on-line dialysate generator, and a second dialysate pump in fluid communication with the on-line dialysate generator. The dialysis system also includes a dialyzer in fluid communication with the first and second dialysate pumps. The dialysis system further includes a first valve located between the first dialysate pump and the dialyzer and a second valve located between the second dialysate pump and the dialyzer. The dialysis system is configured to alternate pumping of dialysate from the first and second dialysate pumps to the dialyzer using the first and second valves.

Abstract: The invention relates to a connector for a container with a spiking solution for individual adjustment of dialysis solutions and/or dialysis concentrates. The connector ensures a contamination-free introduction of the spiking solution into the container of the dialysis solution and/or of the dialysis concentrate and reliable labeling of same as soon as the original contents have been altered by adding a spiking solution.

Abstract: A dry peritoneal dialysis (PD) concentrate system may be used in connection with a PD cycler. The dry PD concentrate system includes a concentrate container with at least two concentrate compartments, and at least one of the compartments contains a dry PD concentrate component. At least one of the concentrate compartments has a medical fluid outlet, and at least one of the concentrate compartments has a diluent inlet.

Abstract: Envisaged herein are methods for determining the optimal volume of contrast medium to be administered to a patient. More particularly, the methods envisaged herein comprise the steps of (a) measuring one or more patient-specific physiological parameters, said one or more patient-specific physiological parameters comprising at least the patient's heart rate; and (b) determining the optimal volume of contrast medium based on the patient-specific physiological parameters determined under (a).

Abstract: An apparatus has a syringe housing. A plunger has a shaft, wherein the plunger is slidably received within the syringe housing between a first and second position. A Hall sensor is disposed within the shaft and a magnet is fixed proximate the syringe housing.

Abstract: A method for performing a medical procedure requiring effective, reliable and foolproof delivery of controlled amounts of a medical grade gas to a patient includes providing a compressed gas cylinder having a weight with medical grade gas sealed therein of at least twelve grams and not greater than fifty grams. The method also includes connecting the compressed gas cylinder to an integrated compressed gas unit including a regulator valve assembly positioned between an outlet port and an inlet port, wherein the regulator valve assembly includes a press button actuator and regulator adjustment dial. A flow control system is secured to the compressed gas unit and the medical grade gas is delivered in precisely controlled amounts by actuating the compressed gas unit and operating the flow control system to deliver the medical grade gas to vasculature of the patient.

Abstract: The present disclosure discloses a system and a method for determining an injectable amount of bile required for a patient after gallbladder removal. The system comprises a receiving module, a creating module, and a determining module. The receiving module may receive a bile-flow rate, physiological parameters of a patient, and amount of fatty food in an alimentary tract of the patient. Based on these data received, the creating module may create a graph. Further, the determining module may determine a correlation between the bile-flow rate and the amount of fatty food in the alimentary tract based on the graph created. The correlation may be determined corresponding to a normal person and the patient which may be seen by two separate curves on the graph. Further, the determining module may determine an injectable amount of bile required for the patient based on the correlation.

Abstract: Disclosed is a needle insertion arrangement (1) with a drive mechanism (9) comprising: a belt (15) frictionally engaging a first roller (10) and a needle retainer (7) with an injection needle (2) fixed to the belt, the first roller being rotatably arranged about an axis (A), a second roller (11) also rotatably arranged about the axis (A), a first spring (13) rotatably biasing the first roller against the second roller, a second spring (14) rotatably biasing the second roller against an arrester (12), the first and the second roller being connected via an internal protrusion (10.2) and arcuate slot (11.

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) comprising a rotatable wheel (10) with a notch (12) having a closed curve geometry comprising a curved section (12.1) and a linear section (12.2), wherein at least one cross beam (15, 16) is movably arranged and engageable to an injection needle (2) to move it between a retracted position (RP) and an extended position (EP), wherein the cross beam (15, 6) comprises a cam (15.1, 16.1) adapted to engage the notch (12).

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) comprising an actuator (5) coupled to a parallel linkage (10) adapted to convert a linear movement of the actuator (5) in a longitudinal direction (L) to a linear movement of a cross beam (7) in transverse direction (T) substantially at right angles with respect to the longitudinal direction (L).

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) comprising:—a cross beam (16) linearly movable in a distal direction (D) and a proximal direction (P) for moving an injection needle (2),—an actuator (5),—a slider (12) coupled to the actuator (5) and linearly movable in a transversal direction (T) at right angles relative the distal direction D and the proximal direction D,—a cam (14) on one of the cross beam (16) and the slider (12),—a guide track (13) in the other one of the cross beam (16) and the slider (12) adapted to engage the cam (14), the guide track comprising a sloped section (13.3) such that the cross beam (16) is moved on movement of the slider (12).

Abstract: A medical therapy system to deliver a pre-bolus volume of medicant is disclosed. The medical therapy system includes an infusion pump that has a case containing a processor, memory, a drive mechanism, a reservoir, communication hardware and a sensor system. The infusion pump further includes a global positioning system (GPS) receiver to determine GPS coordinates of the infusion pump. The GPS receiver is coupled to the processor that executes stored program instructions to provide notification for confirmation to deliver a pre-bolus volume from the reservoir when the GPS coordinates of the infusion pump are within a specified proximity of GPS coordinates of a saved location.

Abstract: The invention relates to an apparatus for automatic ejection of a fluid, having a drive train for automatically ejecting the fluid from a fluid reservoir through an ejection channel, and having a control unit (510) for controlling the apparatus, the control unit (510) being configured to detect failures of drive train actuation steps (610, 620), during which the drive train is actuated for priming or fluid dose ejection, the control unit (510) being further configured to control the apparatus as a function of an actuation step failure number, the actuation step failure number being the number of failed drive train actuation steps (610, 620) since the last successful drive train actuation step (610, 620). The invention further relates to a system comprising such an apparatus a disposable assembly attachable to the apparatus and to a method for controlling such an apparatus.

Abstract: Described herein is a programmable portable infusion device. The infusion device may include electronics such as sensors, and can be programmed to detect parameters related to the proper administration of infusion. If the sensors detect that a parameter is outside of a defined boundary or range, the infusion device may notify a user that it may not be safe to administer infusion and may prevent infusion from occurring.

Abstract: An autoinjector that automatically retracts a needle contained therein includes an injection assembly, having a plunger and a movable piston coupled to the plunger, a retraction assembly coupled to the injection assembly, and an end-of-dose visual indicator disposed within the retraction assembly. The retraction assembly includes an opaque section, a transparent or translucent section coupled to the opaque section, and a drug container having a hypodermic needle. The end-of-dose visual indicator is disposed within the retraction assembly such that the indicator moves upwardly from the opaque section of the retraction assembly to the transparent or translucent section of the retraction assembly upon full administration of a drug solution or medicine contained within the drug container. The end-of-dose visual indicator may be configured according to many preferred embodiments, among which may include a hollow cylinder, a split indicator ring, a co-extruded ring, and a multi-faceted polygonal cylinder.

Abstract: The present invention relates to an autoinjector device (10) for use in combination with a syringe (30), said syringe comprising a movable plunger; a needle; and a tubular needle shield (34). The claimed autoinjector device (10) comprises: an elongated housing having a proximal (11) and a distal end (12); a drive mechanism; a syringe holder (40) in order to support the fragile syringe and to prevent damage to the syringe. The invention furthermore relates to a method for assembly of the autoinjector device according to the invention.

Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.

Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.

Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.

Abstract: The invention relates to an apparatus for ejecting a fluid having a control unit (510) for controlling the apparatus, the control unit (510) being configured to control fluid dose ejection steps and to determine a priming time length (Tprime), the priming time length (Tprime) being the length of time since the last ejection of a fluid volume through the ejection channel, wherein the control unit (510) is further configured to perform a priming test step (612-618) comprising the steps of: determining whether the priming time length (Tprime) is longer than a predefined priming threshold time length (Tthreshold); and setting the apparatus into a status, in which a further fluid dose ejection step is only allowed after execution of an ejection channel priming step (622-628) if the priming time length (Tprime) is longer than the priming threshold time length (Tthreshold).

Abstract: A medicament delivery device includes a housing arranged to accommodate a medicament container, and a drive unit operably arranged to act on an accommodated medicament container for expelling a dose of medicament. The drive unit includes a plunger rod, a force element operably connected to the plunger rod, a connector arranged to releasably hold the plunger rod, an actuator element operably arranged to the connector, and a manually operable actuator arranged to act on the actuator element for releasing the connector when operated. A safety device is arranged to releasably hold the actuator element in a locking position with the connector, preventing unintended release of the plunger rod.

Abstract: The dosing apparatus comprises a conveying device (5), which is driven by at least one conveying drive (4), for conveying fluid from the interior (3) of a container (2). The fluid by means of the conveying device (5) is conveyable from the container to a dispensing opening (6). The conveying device (5) comprises a cylinder (7) having at least one intake opening (11) and at least one outlet opening (12) on an inner cylinder wall (8), and a first piston (9) and a second piston (10). The first piston (9) and the second piston (10) are mounted within the cylinder (7) so as to be displaceable in the longitudinal direction. Furthermore, the first piston (9) and the second piston (10) between the end sides thereof and together with a portion of the inner cylinder wall (8) delimit a variable fluid volume (17).

Abstract: An assembly for a drug delivery device (1) is described which comprises a cartridge (4) containing a plurality of doses of a drug and a piston rod (9) adapted and arranged to expel drug from the cartridge (4) during a dose delivery operation of the assembly, the piston rod (9) comprising a thread (9a). The assembly further comprises a nut member (13), wherein the nut member (13) is adapted and arranged to be rotated with respect to the piston rod (9) about a rotational axis (7) during a dose setting operation of the assembly, the nut member (13) thereby being axially displaced along the piston rod (9) from a start position towards an end position with respect to the piston rod (9) due to mechanical cooperation of the nut member (13) with the thread (9a).

Abstract: Disclosed are systems and methods of detecting an impulse of energy given off by an injection device and determining a dosage of medicine based on the impulse. In one example, a module detects the vibrations given off by dialing a click-wheel on an autoinjector and determining the selected dosage of medicine based on the dialed dosage.

Abstract: Described herein are syringe accessories that can be attached to standard syringes. These accessories utilize one or more mechanisms that can provide at least one additional sensory feedback to the user when performing an aliquot or dosed injection. In other embodiments, the accessories can prevent overdosing.

Abstract: A drive mechanism (4) for a drug delivery device comprising—a piston rod (14), —a trigger member (9) coupled with the piston rod (14) in such a manner that rotational movement between the piston rod (14) and the trigger member (9) is constrained in a first state, the trigger member (9) being elastically deformable in such a manner that the piston rod (14) is rotationally moveable with respect to the trigger member (9) in a second state, —a trigger button (10) being suitable for activating the deformation of the trigger member (9).

Abstract: Described herein is a smart dose monitoring device. The dose monitoring device may include electronics such as motion sensors, orientation sensors, and timers related to monitoring the time of and amount of dose administered during an injection event.

Abstract: A cap assembly (200) for a drug delivery device is presented. The cap assembly (200) comprises a fixing element (134) with a connection feature (154), an outer part (130) with an opening (164), and an inner part (131) being located inside of the outer part (130), the inner part (131) further comprising a corresponding connection feature (170), wherein a section of the fixing element (134) extends through the opening (164) of the outer part (130), such that the fixing element (134) is connected to the inner part (131) by an interaction of the connection feature (154) and the corresponding connection feature (170).

Abstract: A medicament delivery device includes a housing having distal and proximal ends along a longitudinal axis. The housing is arranged to accommodate a medicament container and a delivery member connected to the container; a reloadable drive mechanism for acting on an accommodated container; a delivery member cover at the proximal end and slidable in relation to the housing along the axis; and a cover lock mechanism that includes a first lock member on an actuator movably arranged in relation to the housing and a second lock member on the cover. The first lock member engages the second lock member to block movement of the cover, and the actuator is movable in relation to the cover such that manually actuating the actuator generally transverse to the axis causes the first lock member to be moved out of engagement with the second lock member, thereby allowing the cover to be moved.

Abstract: An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.

Abstract: A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural/intravascular injection, reduced incidence of injury through pricking/piercing, and/or the like.

Abstract: An air stop membrane can be used within an IV set to maintain a fluid column within the IV set downstream of the membrane even after a fluid bag has emptied. By maintaining a fluid column downstream of the membrane, air is prevented from entering into the tubing that couples the IV set to a vascular access device. For this reason, once a fluid bag has emptied, a new fluid bag can be coupled to the IV set without needing to re-prime the IV set. Therefore, a clinician need not be present as a fluid bag is emptying to ensure that air does not enter the tubing.

Abstract: An IV set can include an air stop membrane and one or more additional components including a zero dead space luer access device, a vent cap, a bubble removal component, an antimicrobial coating, insert, or filter, or a precision flow controller. An air stop membrane can be used within the IV set to maintain a fluid column within the IV set downstream of the membrane even after a fluid bag has emptied. By maintaining a fluid column downstream of the membrane, air is prevented from entering into the tubing that couples the IV set to a vascular access device. For this reason, once a fluid bag has emptied, a new fluid bag can be coupled to the IV set without needing to re-prime the IV set. Therefore, a clinician need not be present as a fluid bag is emptying to ensure that air does not enter the tubing.

Abstract: A droplet medicament delivery device for delivering a volume of a medicament from a reservoir. The device includes a device body; a valve chamber surrounded by a chamber wall movably arranged in the device body between at least a first position and a second position; at least one passage extending through the chamber wall; a valve; a valve outlet; a droplet generating device connected to the valve outlet; and an actuator arranged in the valve chamber. The actuator, when activated, delivers medicament from the valve chamber via the valve outlet. The valve inlet is open to the valve chamber and the valve outlet is closed when the chamber wall is in the first position, and the valve inlet is closed and the valve outlet is open when the chamber wall is in the second position.

Abstract: A process and a metered dose inhaler, comprising: an air actuator comprising at least one inlet of liquefied gas (LG), at least one air outlet, at least one first LG-expanding volume and at least one second air-containing volume, the first and second volumes are effectively separated by means of a LG-blocking member; a container with an LG source; said container is in a fluid connection with said LG-expanding volume via the at least one LG inlet; The air actuator is facilitating a metered dose airflow by allowing the expansion of said LG in said at least one LG-expanding volume from its condensed liquid phase to its expanded gas phase. The expansion of said LG facilitates the compression of the air within said at least one air-containing volume, such that a metered dose LG-free air flow is inhalable via at least one air outlet.

Abstract: The present document describes a flow measuring apparatus for measuring the air flow through a section of an inhalation apparatus, and for measuring the drug delivery by inhalation using an inhalation apparatus. The flow measuring apparatus comprises a set of Pitot tubes configured for traversing entirely the lumen of the section of an inhalation apparatus. The set of Pitot tubes comprises a first and second Pitot tube which are respectively fluidly connected to a differential pressure sensor, for measuring a difference between a dynamic pressure and a static pressure within the flow measuring apparatus.

Abstract: An electronic vaporization device, used for the purpose of inhalation of vapor created by using an ultrasonic signal generator to vaporize a solid or liquid; the apparatus also employs a Langevin transducer, a horn, and a probe, which is attached to the horn and is bent to optimize vibrational amplitude/displacement at the tip.

Abstract: A medical system having a ventilator coupled to a breathing circuit is provided. The ventilator is configured to exchange gases with the patient via the breathing circuit. The system includes one or more sensors configured to acquire measurement data associated with the patient, and a memory storing the measurement data. The system further includes a monitor configured to display a tidal volume and lung compliance viewer, and a processor. The processor is programmed to display a virtual gauge within the tidal volume and lung compliance viewer displayed on the monitor. The virtual gauge having a tidal volume indicator and a tidal volume and compliance indicator. The tidal volume and compliance indicator includes a color pattern positioned along a side of the tidal volume indicator. The color pattern representing a degree of tidal volume and compliance relationship with respect to a position on the virtual gauge.

Abstract: Respiratory therapy apparatus includes an expiratory therapy device (100) that produces an oscillating resistance to breathing. The device has a vibration sensor (20) mounted on its housing (2) that transmits signals to a receiver (200) indicative of operation of the device. An accelerometer (201) is secured to the chest of the patient; this also transmits signals to the receiver (200). The apparatus prompts the user to use the device (100) at each of its different settings and the receiver (300) monitors the effect of the different settings and computes which gives the most benefit. The receiver (300) then prompts the user to select the optimum set ting for further therapy.

Abstract: The invention relates to an operating- and information system for a breathing apparatus, comprising a display for displaying information and for displaying operating fields for the user, and comprising at least one touch-sensitive input field arranged in close proximity to the displayed operating field. According to the invention, a first operating field and a second operating field are displayed in the region of the display, and a processing unit, which is coupled to the display and to the touch-sensitive input unit, is designed to register an operation of the first operating field via the touch-sensitive input unit, and, in accordance therewith, to cause the control unit to execute the function associated with the operating field.

Abstract: Endotracheal devices, systems, and methods of using the same for transpulmonary thermal transfer to, e.g., induce transpulmonary hypothermia and/or warming are described herein.

Abstract: An anesthesia administration system is provided that provides gaseous anesthesia to a patient's nose while providing access to the patient's mouth. The anesthesia administration system includes a face mask having an integrally formed gas inlet channel, an integrally formed gas outlet channel, and an integrally formed gas sampling channel.

Abstract: A method of creating a CPAP mask assembly, that makes use of a CPAP mask, including a rigid portion adapted to connect to an air-delivery hose and to provide structure and a pliable, soft, face-contacting portion, supported by the rigid portion. Also utilized is a mask cover, having an annular piece of bio-compatible, absorbent material, having an outer edge and an inner edge that defines a plain opening and an elastic loop attached about the outer edge, thereby causing the outer edge to retract inwardly. The elastic loop is then placed over the mask so that the material covers the face-contacting portion and the opening is positioned centrally. Then the elastic loop is released, permitting it to retract inwardly so that part of the rigid portion is interposed between the elastic loop and the inner edge, thereby retaining the mask cover about the rigid portion of the mask, without deforming the face-contacting portion.

Abstract: A breathing assistance apparatus is disclosed, for use with delivery of respiratory gases to a patient. The breathing assistance apparatus includes a patient interface, having a body section adapted to cover the nose, or nose and mouth of a patient and a sealing interface. The sealing interface includes at least an outer sealing member. The outer sealing member is adapted to attach to the body section in a sealing manner and has a substantially thin section in at least its nasal bridge region. The thin section is substantially thinner than the rest of the outer sealing member. The patient interface comprises a mask body and a seal assembly. The seal assembly includes a flexible seal, and a rigid seal clip, the seal assembly being removably attached to the mask body via the rigid seal clip. The mask body and rigid seal clip are profiled to match the contours of a user's face so that the seal has a substantially constant wall depth.

Abstract: A cushion for a patient interface that delivers breathable gas to a patient includes a base wall structured to be connected to a frame, an underlying support cushion extending away from the base wall towards the patient's face in use, and a membrane provided to substantially cover at least a portion of the underlying cushion. The membrane is adapted to form a continuous seal on the patient's face. The underlying cushion has a spring-like connection with the base wall. The underlying cushion and/or base wall define a spring constant that varies along a length of the seal.

Abstract: Equipment for treating obstructive lung disorders includes: a respiratory nozzle (2) including at least one air filtering element (21) and at least one transponder (22) on which is recorded a unique identifier and elements for storing information characterising the use of respiratory nozzle, and a device (1) designed for facilitating expulsion of mucus, and including at least one receiver (11) associated with the transponder and which only allows initiation of the device after detection of the unique identifier, which device includes at least one microcontroller (12) for the management of the transponder, which is designed both for reading information of this transponder and for modifying the information so as to prevent the use of the respiratory nozzle when the latter has already been used once by a patient or to prevent the initiation of the device if the number of uses of respiratory nozzle is greater than a predetermined threshold.