Patents Issued in September 20, 2016
  • Method for preparing acrolein from glycerol or glycerine
    Patent number: 9447009
    Abstract: A method of preparing acrolein from glycerol or glycerine is disclosed. The method includes dehydrating glycerol or glycerine in the presence of a catalyst consisting of at least (a) a mixed oxide of zirconium and at least one metal, said metal being selected from niobium, tantalum and vanadium, or (b) a zirconium oxide and at least one metal oxide, the metal being selected from niobium, tantalum and vanadium, or (c) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, or (d) a titanium oxide and a mixed oxide of zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: September 20, 2016
    Assignees: ADISSEO FRANCE S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Virginie Belliere-Baca, Stephane Loridant, Jean-Marc Millet, Pascaline Lauriol-Garbey
  • Method for preparing a herbicidal compound
    Patent number: 9447010
    Abstract: The present invention discloses a simple method for transforming cashew nut shell liquid into an active herbicidal composition.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: September 20, 2016
    Assignee: BANGOR UNIVERSITY
    Inventors: Viacheslav Vitalievich Tverezovskiy, Radek Messias Braganca, Frank Arthur Howard, Spencer Matthew Gould, Paul Anthony Fowler, Mark Stephen Baird
  • Methods, systems and devices for simultaneous production of lactic acid and propylene glycol from glycerol
    Patent number: 9447011
    Abstract: Methods, processes and systems for using solid catalysts to simultaneously produce lactic acid and propylene glycol from glycerol are provide, as are methods, processes and systems of converting glycerol use heterogeneous catalytic agents. Different combinations of catalysts and reaction conditions provide tunable ranges for the yields of lactic acid and propylene glycol. The conversion methods, processes and systems are not reliant on external hydrogen. Applications to crude glycerol, including that co-produced during biodiesel production, are also described.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: September 20, 2016
    Assignee: University of Tennessee Research Foundation
    Inventors: Xiaofei Philip Ye, Lu Liu
  • Synthetic process of adipic acid
    Patent number: 9447012
    Abstract: A process for synthesizing adipic acid comprising the steps of using glucaric acid or galactaric acid as a starting material, using rhenium catalyst and acid catalyst, using one or more reaction solvents selected from a group consisting of heptanol and butanol; and b) subjecting glucaric acid ester or galactaric acid ester obtained from the step a) to hydrogenation reaction with precious metal catalyst, and then hydrolyzing the ester obtained from this reaction to obtain adipic acid.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: September 20, 2016
    Assignees: HYUNDAI MOTOR COMPANY, SNU R&DB FOUNDATION
    Inventors: Chae Hwan Hong, Young Gyu Kim, Nara Shin
  • Method for producing oxide
    Patent number: 9447013
    Abstract: Provided is a method of oxidizing a substrate with excellent oxidizing power to yield a corresponding oxide. The method can employ a commercially available imide compound as intact as a catalyst and can produce the oxide in a high yield under mild conditions. A method for producing an oxide according to the present invention includes performing oxidation of a substrate in the presence of oxygen and ozone under catalysis of an imide compound to yield a corresponding oxide. The imide compound has a cyclic imide skeleton represented by Formula (I). In the formula, n is selected from 0 and 1; and X is selected from an oxygen atom and an —OR group, where R is selected from hydrogen and a hydroxy-protecting group.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: September 20, 2016
    Assignee: DAICEL CORPORATION
    Inventors: Yasutaka Ishii, Ichiro Takase, Yoshiya Narasaki, Takamasa Suzuki
  • Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
    Patent number: 9447014
    Abstract: The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 20, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Thomas K. Karami, Scott W. Smith, Fiona Dubas-Fisher, Adrian St. Clair Brown
  • ()-2?-vinyl-abscisic acid derivatives
    Patent number: 9447015
    Abstract: The invention relates to a novel class of (S)-2?-vinyl-substituted-abscisic acid derivatives, and to methods of synthesizing and using the derivatives.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: September 20, 2016
    Assignee: Valent BioSciences Corporation
    Inventors: Gary T. Wang, Daniel F. Heiman, Gregory D. Venburg, Joseph Lustig, Marci Ann Surpin, Robert Erwin Fritts, Jr., Franklin Paul Silverman, Derek D. Woolard
  • Method for the preparation of triglycerides of medium-chain length fatty acids
    Patent number: 9447016
    Abstract: A method is disclosed for the preparation of glycerol esters (triglycerides) of medium-chain length monocarboxylic fatty acids which consists of the reaction of the precursor free fatty acid and glycerol in the presence of a catalyst under partial vacuum. The process preferably uses a metal catalyst such as an oxide or a chloride of tungsten, molybdenum, calcium, zinc, chromium or magnesium. The method of the invention allows the preparation in high yield and high purity (>99.5%) of the final triglyceride. The present method allows the formation of triglycerides without solvent. Are also contemplated, the triglyceride obtained by the method, and the pharmaceutical composition containing the triglyceride as an excipient or as an active ingredient.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: September 20, 2016
    Assignee: Prometic Pharma SMT Limited
    Inventors: Zacharie Boulos, Jean-Simon Duceppe, Christopher Penney
  • Process for the production of 4-alkanoyloxy-2-methylbutanoic acid
    Patent number: 9447017
    Abstract: The present invention relates to an improved process for the production of 4-alkanoyloxy-2-methylbutanoic acid, as well as to the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) for the synthesis of organic compounds comprising isoprene (isoterpene) units, such as ?-carotene or other carotenoids (e.g. canthaxanthin, zeaxanthin or astaxanthin) or as vitamin E or vitamin A as well as other structurally similar compounds.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: September 20, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Jan Schütz, Bettina Wüstenberg, Thomas Netscher
  • Ethyl acetate production
    Patent number: 9447018
    Abstract: A method of purifying an ethyl acetate stream comprises contacting an inlet stream with a solvent, transferring at least a portion of the impurity compound from the inlet stream into the solvent to form an extract and a purified product, separating the extract from the purified product, separating the portion of the impurity compound from the extract, forming an impurities stream and a regenerated solvent, and recycling at least a portion of the regenerated solvent to contact the inlet stream. The inlet stream comprises ethyl acetate and an impurity compound, and the extract comprises the solvent and the portion of the impurity compound transferred from the inlet stream.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: September 20, 2016
    Assignee: Greenyug, LLC
    Inventors: Sagar B. Gadewar, Peter K. Stoimenov
  • Fluorinated CBD compounds, compositions and uses thereof
    Patent number: 9447019
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: September 20, 2016
    Assignees: UNIVERSIDADE DE SAO PAULO-USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof
    Patent number: 9447020
    Abstract: There are provided compounds of formula (I): wherein X1 is O, NH, or S; X2 is O, NH, or S; and X3 is O, NH, or S; and wherein R, R1, T1 and T2 can represent various entities. Such compounds can be useful, for example, for preventing, palliating or treating various diseases such as heart diseases, respiratory diseases, treating inflammatory abnormalities, metabolic disorders or diabetes.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: September 20, 2016
    Assignee: SCF PHARMA INC.
    Inventor: Samuel C. Fortin
  • Process for the purification of aniline from gas phase hydrogenations
    Patent number: 9447021
    Abstract: The present invention relates to a process for the purification of aniline which originates from gas phase hydrogenations. In this process, only a minimum proportion of the aniline has to be evaporated and condensed again. The process is highly efficient in removing compounds which have phenolic hydroxyl groups and results in minimal losses of aniline. This process also reduces the unwanted coupling mechanisms in the division of the overall crude product in the fraction condensation into individual substreams and the subsequent workup of these.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: September 20, 2016
    Assignee: Covestro Deutschland AG
    Inventors: Michael Merkel, Peter Lehner, Bastian Mahr, Amgad Salah Moussa
  • Triarylamine derivative and electrophotographic photosensitive member
    Patent number: 9447022
    Abstract: A triarylamine derivative is represented by general formula (1) shown below. In general formula (1), R1, R2, and R3 each represent, independently of one another, a halogen atom, an optionally substituted alkyl group having a carbon number of at least 1 and no greater than 6, an optionally substituted alkoxy group having a carbon number of at least 1 and no greater than 6, or an optionally substituted aryl group having a carbon number of at least 6 and no greater than 12. In general formula (1), o, p, and q each represent, independently of one another, an integer of at least 0 and no greater than 4, and m and n each represent, independently of one another, an integer of at least 1 and no greater than 2.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: September 20, 2016
    Assignee: KYOCERA Document Solutions Inc.
    Inventors: Hideki Okada, Fumio Sugai, Kensuke Kojima
  • Curcumin and tetrahydrocurcumin derivatives
    Patent number: 9447023
    Abstract: The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: September 20, 2016
    Assignee: Research Foundation of the City University of New York
    Inventors: Krishnaswami Raja, Probal Banerjee, Andrew Auerbach, Wei Shi, William L'Amoreaux
  • Process for the preparation of lacosamide
    Patent number: 9447024
    Abstract: A novel process for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (Lacosamide) is described. It comprises reacting N-acetyl-D-serine methyl ester with benzylamine catalyzed by a non-nucleophilic base to obtain (R)-2-acetamido-2-N-benzyl-3-hydroxy propionamide followed by its methylation.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 20, 2016
    Assignee: Divi's Laboratories Limited
    Inventors: Satchandra Kiran Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • Bicyclic analgesic compounds
    Patent number: 9447025
    Abstract: Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 20, 2016
    Assignee: Kalyra Pharmaceuticals, Inc.
    Inventor: Kevin Duane Bunker
  • Bicyclic analgesic compounds
    Patent number: 9447026
    Abstract: Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 20, 2016
    Assignee: Kalyra Pharmaceuticals, Inc.
    Inventor: Kevin Duane Bunker
  • Treating long QT syndrome
    Patent number: 9447027
    Abstract: This document relates to compounds useful for treating cardiac arrhythmias, for example, long QT syndrome. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: September 20, 2016
    Assignee: The General Hospital Corporation
    Inventors: David J. Milan, David S. Peal
  • Therapeutic aryl-amido-aryl compounds and their use
    Patent number: 9447028
    Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as “AAA compounds”), which, inter alia, are (selective) retinoic acid receptor ? (RAR?) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RAR?, and in the treatment of diseases and conditions that are mediated by RAR?, that are ameliorated by the activation of RAR?, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimer's disease, early stage Alzheimer's disease, intermediate stage Alzheimer's disease, late stage Alzheimer's disease, cognitive impairment, and mild cognitive impairment.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: September 20, 2016
    Assignee: King's College London
    Inventors: Jonathan Patrick Thomas Corcoran, Sarkis Barret Kalindjian, Alan David Borthwick, David Reginald Adams, Jane Theresa Brown, David Michel Adrien Taddei, Jason John Shiers
  • Fluorinated arylalkylaminocarboxamide derivatives
    Patent number: 9447029
    Abstract: Fluorinated arylalkylaminocarboxamide derivatives of formula (I) are described wherein W, J, n, R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositions containing them as active ingredients and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urological, and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: September 20, 2016
    Assignee: NEWRON PHARMACEUTICALS S.P.A.
    Inventor: Paolo Pevarello
  • Inhibitors of histone deacetylase
    Patent number: 9447030
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: September 20, 2016
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation, The Broad Institute, Inc.
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen Haggarty, Yan-Ling Zhang
  • Compound, poly(imide-amide) copolymer, and an article including the poly(imide-amide) copolymer
    Patent number: 9447031
    Abstract: A compound represented by Chemical Formula 1: wherein in Chemical Formula 1, R1 and R2 are the same or different, and are each independently an electron-withdrawing group, R3 to R6 are the same or different, and are each independently selected from a hydrogen, a substituted or unsubstituted C1 to C20 alkyl group, and a substituted or unsubstituted C6 to C20 aryl group, and n11 and n12 are the same or different, and are each independently an integer from 1 to 4.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: September 20, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Dmitry Androsov, Mikhail Kovalev, Evgeny Kiryushchenkov, Fedosya Kalinina
  • Urea stripping process for the production of urea
    Patent number: 9447032
    Abstract: The invention relates to a process for producing urea wherein an aqueous urea solution, leaving a urea reaction zone is fed to a stripper, where a part of the non-converted ammonia and carbon dioxide is separated from the aqueous urea solution, which solution leaves the stripper to a first recovery section of one or more serial recovery sections and is subsequently fed to one or more urea concentration sections, wherein the urea solution leaving the stripper is subjected to an adiabatic expansion, thus creating a vapor and a liquid, which are separated before the liquid enters a first recovery section and the vapor is condensed. The invention further relates to a urea plant comprising a stripper and a first recovery section, wherein an adiabatic expansion valve and a liquid/gas separator is provided between the stripper and the first recovery section.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: September 20, 2016
    Assignee: STAMICARBON B.V.
    Inventor: Johannes Henricus Mennen
  • Potassium channel blockers
    Patent number: 9447033
    Abstract: The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein X1, R1, R2, R3, R4, and R5 are defined as set forth in the specification. The compounds are useful as potassium ion channel inhibitors.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: September 20, 2016
    Assignee: Japan Tobacco Inc.
    Inventors: Mushtaq Mulla, Derek Edward John, Richard John Hamlyn, Sasha Louise Garrett, Basil Hartzoulakis, David Madge, John Ford
  • Industrial methods for producing arylsulfur pentafluorides
    Patent number: 9447034
    Abstract: Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the absence or presence of one or more additives selected from a group of fluoride salts, non-fluoride salts, and unsaturated organic compounds to form arylsulfur pentafluorides.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: September 20, 2016
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Teruo Umemoto, Norimichi Saito
  • Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4
    Patent number: 9447035
    Abstract: The invention relates to compounds of formula I: wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to VLA-4 integrin antagonists to target cells expressing VLA-4.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: September 20, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert Alan Goodnow, Jr., Matthew Michael Hamilton, Achyutharao Sidduri
  • Process for the preparation of optionally substituted phenyl and pyridyl pyrrolidines
    Patent number: 9447036
    Abstract: The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: September 20, 2016
    Assignee: Bayer Cropscience AG
    Inventors: Friedrich August Muehlthau, Mark James Ford
  • 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide as alpha 7 nAChR modulator
    Patent number: 9447037
    Abstract: Disclosed are an alpha 7 nAChR receptor modulator compound, 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yljbenzenesulfonamide, its tautomeric form, its pharmaceutically acceptable salts, pharmaceutical compositions comprising the compound or a salt thereof, and a method of treating various diseases, disorders or conditions, for example, Alzheimer's disease, mild cognitive impairment, senile dementia, vascular dementia, dementia of Parkinson's disease, and attention deficit disorder.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: September 20, 2016
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Navnath Popat Karche, Ajay Ramchandra Tilekar, Venkata P. Palle, Rajender Kumar Kamboj
  • Substituted B-amino acid derivatives as CXCR3 receptor antagonists
    Patent number: 9447038
    Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: September 20, 2016
    Assignee: Sanofi
    Inventors: Imre Bata, Veronika Bartane Bodor, Attila Vasas, Peter Buzder-Lantos, Gyorgy Ferenczy, Zsuzsanna Tomoskozi, Gabor Szeleczky, Zsuzsanna Szamosvolgyi
  • Indole carboxamide derivatives and uses thereof
    Patent number: 9447039
    Abstract: A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: September 20, 2016
    Assignee: Novartis AG
    Inventors: Jan Jiricek, Ravinder Reddy Kondreddi, Paul William Smith
  • Tricyclic compounds, compositions comprising them and uses thereof
    Patent number: 9447040
    Abstract: Tricyclic compounds, compositions and uses thereof in the treatment of at least one disease, disorder or condition such as for example obesity, overweight, abnormal fat-distribution and any conditions or disease associated therewith.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: September 20, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Shmuel Ben-Sasson, Arie Dagan, Sharon Perles
  • Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
    Patent number: 9447041
    Abstract: The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (I) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: September 20, 2016
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Antonio Garrido Montalban, Daniel J. Buzard, John A. DeMattei, Tawfik Gharbaoui, Stephen R. Johannsen, Ashwin M. Krishnan, Young Mi Kuhlman, You-An Ma, Michael John Martinelli, Suzanne Michiko Sato, Dipanjan Sengupta
  • Endoparasite control agent
    Patent number: 9447042
    Abstract: Provided are an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient, and a method for controlling endoparasites, comprising orally or parenterally administering the endoparasite control agent.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: September 20, 2016
    Assignees: THE UNIVERSITY OF TOKYO, NIHON NOHYAKU CO., LTD.
    Inventors: Kiyoshi Kita, Akiyuki Suwa
  • Thioaryl derivatives as GPR120 agonists
    Patent number: 9447044
    Abstract: The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: September 20, 2016
    Assignee: LG LIFE SCIENCES LTD.
    Inventors: Young Kwan Kim, Myoung Yeol Kim, Sang Yun Park, Ok Ku Park, Vasily Artemov, Sang Dae Lee, Hyun Woo Joo, Eun Sil Choi
  • Histone demethylase inhibitors
    Patent number: 9447045
    Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: September 20, 2016
    Assignee: Celgene Quanticel Research, Inc.
    Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
  • Histone demethylase inhibitors
    Patent number: 9447046
    Abstract: The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 20, 2016
    Assignee: Celegene Quanticel Research, Inc.
    Inventors: Amogh Boloor, Young K. Chen, Michael Brennan Wallace
  • Inhibitors of protein phosphatase-1 and uses thereof
    Patent number: 9447047
    Abstract: Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 20, 2016
    Assignees: Howard University, The Board of Regents of the University of Texas System
    Inventors: Sergei Nekhai, Alexander Bukreyev
  • Processes for the preparation of pesticidal compounds
    Patent number: 9447048
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: September 20, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, Greg Whiteker, Carl DeAmicis, Kaitlyn Gray, Yu Zhang, Joseck M. Muhuhi
  • Compounds for treatment of cancer
    Patent number: 9447049
    Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: September 20, 2016
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Wei Li, Min Xiao, James Dalton, Sunjoo Ahn, Duane D. Miller, Jianjuan Chen, Jin Wang
  • Solid forms of curcumin
    Patent number: 9447050
    Abstract: The present invention provides forms of curcumin and the pharmaceutical compositions thereof. The forms of curcumin disclosed herein are curcumin polymorph Form III, curcumin-2-aminobenzimidazole co-crystal, and curcumin-L-lysine co-crystal. Further, the invention provides methods inhibiting cancer cells and HSV-1 using these curcumin novel solid forms.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: September 20, 2016
    Assignees: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, VAN ANDEL RESEARCH INSTITUTE
    Inventors: Stephen T. Gately, Steven J. Triezenberg, Tong Wang
  • Diaminopyrimidines and uses thereof
    Patent number: 9447051
    Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: September 20, 2016
    Assignee: AbbVie Inc.
    Inventors: Tatyana Dekhtyar, Arthur Gomtsyan, M-Akhteruzzaman Molla, Anil Vasudevan, Iok Chan Ng, Mikhail Chafeev
  • Processes for preparing pyrimidine compounds
    Patent number: 9447052
    Abstract: This invention relates to methods of making a compound of formula (I) and intermediates for same the compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: September 20, 2016
    Assignee: Glaxo Group Limited
    Inventors: Kevin Stuart Cardwell, Claire Frances Crawford, Suzanne Helen Davies, Charles Edward Wade
  • Process for the preparation of calcobutrol
    Patent number: 9447053
    Abstract: A process for the preparation of the calcium complex of 10-(2, 3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclodecane-4,7-triacetic acid, also known as Calcobutrol, starting from the pure gadolinium complex (Gadobutrol) is disclosed. Also disclosed is Calcobutrol with a hitherto unknown level of purity.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: September 20, 2016
    Assignee: Bayer Intellectual Property GMBH
    Inventors: Johannes Platzek, Wilhelm Trentmann
  • Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
    Patent number: 9447054
    Abstract: Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: September 20, 2016
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jie Young Song, Ji Yeon Ahn, In Sung Jung, Saelooom Lee, Arang Son, Ky Youb Nam, Hyun Kyung Choi, Seung Yong Seo, Yuan Yue
  • ?-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
    Patent number: 9447055
    Abstract: The invention provides ?-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1?-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: September 20, 2016
    Assignee: Merck Serono S.A.
    Inventors: Patrick Naxos Page, Matthias Schwarz, Catherine Jorand-Lebrun, Anna Quattropani, Vincent Pomel
  • Solid forms of epalrestat
    Patent number: 9447056
    Abstract: The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: September 20, 2016
    Assignee: BIONEVIA PHARMACEUTICALS, INC.
    Inventors: Isabel Kalofonos, G. Patrick Stahly, William Martin-Doyle, Dimitris Kalofonos, Jeffrey S. Stults, Travis L. Houston
  • Schiff bases of thiazoles: a new class of ureases inhibitors
    Patent number: 9447057
    Abstract: One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a compound selected from a group consisting of 28 thiazoles Schiff bases. Kinetic studies were performed on ten (10) of the most active compounds.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: September 20, 2016
    Inventors: Muhammad Iqbal Choudhary, Ajmal Khan, Khalid M. Khan, Nida Ambreen, Atia-tul Wahab, Atta-ur Rahman
  • Substituted 1,3-thiazoles as heat shock transcription factor 1 activators
    Patent number: 9447058
    Abstract: The present invention relates to 1,3-thiazole compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixtures thereof), and pharmaceutical Formulations thereof.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 20, 2016
    Assignees: Duke University, Chaperone Therapeutics, Inc.
    Inventors: Dennis J. Thiele, Daniel W. Neef, Jose S. Mendoza
  • Intermediate for manufacture of polymerizable compound and process for manufacture thereof
    Patent number: 9447059
    Abstract: The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, Ax is an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, Ay is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group having 2 to 18 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, or the like. Ax and Ay optionally bond to each other to form a ring, and Q is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like.).
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: September 20, 2016
    Assignee: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama, Yasushi Nakano