Patents Issued in September 20, 2016
  • Patent number: 9447361
    Abstract: The present invention relates to the use of at least one vegetable oil refining industry by-product to obtain a purified total unsaponifiable of vegetable oil cleared of the impurities initially present in the said by-product, advantageously cleared of sapid and odorous compounds and/or chemical compounds resulting from the deterioration and the degradation of vegetable oils. The invention further relates to a method for obtaining a purified total unsaponifiable of vegetable oil from at least one vegetable oil refining industry by-product. The invention further relates to a purified total unsaponifiable of vegetable oil able to be obtained by this method, as well as compositions containing such an unsaponifiable. The invention further relates to such unsaponifiables or such compositions for the use thereof as a drug, medical device, dermatological agent, cosmetic agent or nutraceutical, in humans or animals.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: September 20, 2016
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Jacques Legrand, Alex Saunois, Caroline Baudouin, Philippe Msika
  • Patent number: 9447362
    Abstract: Provided are a compound and a fragrance composition containing the same, wherein the compound has a spicy tone that is useful as a fragrance, particularly a cumin-like odor, it is stable in an aqueous vehicle, and it emphasizes spicy-, green-, floral-, woody-, and citrus-like various odors by being blended with other fragrances, which allows oil-, chemical-, and metallic-like undesirable odors to be suppressed. A nitrile compound represented by Formula (I-3), Formula (I-2), or Formula (I-1).
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: September 20, 2016
    Assignee: Kao Corporation
    Inventors: Tomotaka Matsumoto, Takashi Aoki, Takahiro Hirose, Shoichi Tahara, Herwick Tan, Natacha Jerome
  • Patent number: 9447363
    Abstract: The present invention relates to compositions comprising polyaspartic acid (PAS) derivatives and the use of said compositions in washing processes, especially in automatic dishwashing.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: September 20, 2016
    Assignee: RECKITT BENCKISER FINISH B.V.
    Inventors: Judith Preuschen, Ralf Wiedemann
  • Patent number: 9447364
    Abstract: A method of providing a fragrant odor to an application, comprising the addition thereto of at least one compound of the formula I wherein X and Y are independently selected from the group consisting of —CR1R2R3, —NR4R5 and —OR6, wherein R1 to R5 are selected from H and essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom, and R6 is selected from essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom; and, A is an essentially hydrocarbon moiety that optionally comprises at least one oxygen, sulphur, nitrogen or silicon atom, with the proviso that the compound A-CHO is a fragrant aldehyde. The use of these compounds in laundry, household and personal care products confers a long-lasting freshness.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: September 20, 2016
    Assignee: Givaudan S.A.
    Inventor: Felix Flachsmann
  • Patent number: 9447365
    Abstract: A method including immersing a ceramic coated article into a bath including an HF acid solution having NH4F with a molar concentration of about 0.1M to 1.0M for a time period to remove a deposition, and rinsing the ceramic coated article.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: September 20, 2016
    Assignee: Applied Materials, Inc.
    Inventors: Sumanth Banda, Jennifer Y. Sun
  • Patent number: 9447366
    Abstract: Organic cleaner/detergent compositions, formulations and solutions, and methods of cleaning using such compositions, formulations and solutions and manufacturing such compositions, formulations and solutions are disclosed. More particularly, compositions; formulations and solutions used for the cleaning and/or cleansing of a variety of industrial, domestic and/or communal hard surfaces, fiber/soft surfaces, including all natural, organic, synthetic and blended fibers, and organic surfaces, including, but not limited to, human skin and hair and animal skin and hair are disclosed. Such compositions, formulations and solutions are useful as laundry detergents, automatic dishwasher detergents, hard surface cleaners, hand soaps, human shampoos, and animal shampoos.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: September 20, 2016
    Assignee: GREENOLOGY PRODUCTS, INC.
    Inventors: Adam McCarthy, David Andrew Gordon
  • Patent number: 9447367
    Abstract: The invention concerns a machine cleaner to clean kitchen appliances, comprising an alkaline system and a complexing component to bind metals or metallic cations, wherein the complexing component comprises a combination of at least one element from each of the following groups of complexing agents or complexing aids: methyl glycine diacetic acid or polyaspartic acid or salts thereof; polyepoxysuccinic acid or salts thereof; and gluconic acid or gluconates. The invention also concerns the use of a combination of different complexing agents or complexing aids in an alkaline machine cleaner as well as the use of a machine cleaner in accordance with the invention to clean kitchen appliances, in particular in the commercial kitchen sector.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: September 20, 2016
    Assignee: BUDICH INTERNATIONAL GMBH
    Inventor: Meinrad Budich
  • Patent number: 9447368
    Abstract: A detergent composition comprising ethylene oxide/propyleneoxide (EO/PO), sodium-2-ethylhexyliminodipropionate, potassium hydroxide, hydroxyethylene diphosphonic acid (HEDP), and diethylenetriamine-penta(methylene phosphonic acid) (DTPMP) for removing contaminants from the surface of a hard disk.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: September 20, 2016
    Assignees: WD MEDIA, LLC, MIPOX CORPORATION
    Inventors: Soh Kian Koo, Kok Kin Yap, Kamaruddin Ayob, Lau Meng Kun
  • Patent number: 9447369
    Abstract: The present invention is directed towards a method and apparatus for making soap. According to one embodiment, a soap making apparatus comprises a water vessel that holds water, an oil vessel that holds an oil mixture, a lye container that accepts enclosed lye capsules and a microcontroller that controls a mixture of ingredients that is discharged from the water vessel, oil vessel and lye vessel to produce one or more soap bars made.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: September 20, 2016
    Assignee: DESIGNED BY M.E., LLC
    Inventors: Chérie Liana Schaible, Tami Deanna Lamp, Stephen John Gaynes
  • Patent number: 9447370
    Abstract: Provided are liquors or spirits that compensate for the oily and grass-like smell of perillaldehyde, the primary aroma component of Perilla frutescens var. crispa (shiso), to ensure that the fresh and natural fragrance of shiso is developed in a balanced way. In the process of making distilled liquors or spirits, the temperature of the distillation feed charged into a distillation vessel is managed appropriately, whereby the aroma components of shiso used as part of the feed can be recovered in a balanced way to produce distilled liquors or spirits having the fresh and natural fragrance of shiso. According to the distillation method of the present invention, no extra equipment investment is required and distilled liquors or spirits of good quality can be obtained with a minimum production cost.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: September 20, 2016
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventor: Takanori Kashima
  • Patent number: 9447371
    Abstract: A holding structure for holding a plurality of culture plates in a stacked arrangement includes a feature for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting of the bottom culture plate from the adjacent culture plate facilitates withdrawal of the bottom culture plate from the base via a robotic plate transfer mechanism. The de-nesting feature can be entirely passive, such as ramps formed in the base of the holding structure.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: September 20, 2016
    Assignee: BIOMERIEUX, INC.
    Inventors: Bruno Colin, Yaneli Iakimova, Kevin G. Ketsenburg, David M. Robbins, Stéphane Bellet
  • Patent number: 9447372
    Abstract: A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: September 20, 2016
    Assignee: bioMerieux, Inc.
    Inventor: Bradford G. Clay
  • Patent number: 9447373
    Abstract: Methods of treating contamination, particularly fungal contamination, in cultures of Haematococcus pluvialis with hydrogen peroxide and salt are described herein. The method comprises dosing the culture comprising a concentration of salt with a concentration of hydrogen peroxide based on the stage of the cells in the culturing process and at a frequency to increase the likelihood of the cells surviving until the process of accumulating carotenoids, such as astaxanthin, is complete.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 20, 2016
    Assignee: HELIAE DEVELOPMENT LLC
    Inventors: Laura Carney, Kristine Sorensen
  • Patent number: 9447374
    Abstract: Methods of treating contamination, particularly fungal contamination, in cultures of Haematococcus pluvialis with hydrogen peroxide are described herein. The method comprises detecting the contamination and then dosing the culture with a concentration of hydrogen peroxide based on the stage of the cells in the culturing process and at a frequency to increase the likelihood of the cells surviving until the process of accumulating carotenoids, such as astaxanthin, is complete.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 20, 2016
    Assignee: HELIAE DEVELOPMENT LLC
    Inventors: Laura Carney, Kristine Sorensen
  • Patent number: 9447375
    Abstract: Methods of treating lysis in cultures of Haematococcus pluvialis with hydrogen peroxide are described herein. The method comprises dosing the culture comprising with a concentration of hydrogen peroxide based on the stage of the cells in the culturing process and at a frequency to increase the likelihood of the cells surviving until the process of accumulating carotenoids, such as astaxanthin, is complete.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: September 20, 2016
    Assignee: HELIAE DEVELOPMENT LLC
    Inventors: Laura Carney, Kristine Sorensen
  • Patent number: 9447376
    Abstract: In one aspect, the present invention is directed to a dried intimate mixture comprising a bacteria spore and a germinative compound, and methods for preparing the intimate mixture. In another aspect, this invention is directed to a composition comprising such an intimate mixture. The invention also relates to methods for increasing the germination, growth, metabolism, and/or enzyme activity of a bacteria spore comprising preparing an intimate mixture of a bacteria spore and a germinative compound.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: September 20, 2016
    Assignee: Envera, LLC
    Inventors: Tommie Eugene Hashman, Michael Matheny
  • Patent number: 9447377
    Abstract: The present inventions describes a method that, starting from pluripotent cells, leads to the obtainment, in a reproducible and efficient manner, of endodermal cells precursor. These cells reveal useful also for application in the regenerative therapy.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: September 20, 2016
    Inventors: Stefania Filosa, Genesia Manganelli
  • Patent number: 9447378
    Abstract: The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells, and therapeutic uses of such compositions.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Amanda Dilenno, Jeffrey R. Millman
  • Patent number: 9447379
    Abstract: Methods and compositions for differentiating tissue resident multipotent mesenchmal stromal cells (MSCs) such as adipose tissue resident MSCs into a hematopoietic lineage are described.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: September 20, 2016
    Inventors: Reza Izadpanah, Eckhard Alt
  • Patent number: 9447380
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: September 20, 2016
    Assignees: Regents of The University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Kartik Subramanian, Wei-Shou Hu, Catherine M. Verfaillie, Yonsil Park
  • Patent number: 9447381
    Abstract: A medium for growing vascular lineage cells is described. The vascular lineage cell growth medium includes an oligosaccharide-based hydrogel and a growth factor that promotes vascularization by vascular lineage cells.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: September 20, 2016
    Assignee: The Johns Hopkins University
    Inventors: Sharon Gerecht, Donny Hanjaya-Putra
  • Patent number: 9447382
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: September 20, 2016
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Amanda Mack
  • Patent number: 9447383
    Abstract: Disclosed is a Madin-Darby canine kidney (MDCK)-derived cell line. The MDCK-derived cell line is derived from MDCK cells deposited under accession number ATCC CCL-34. The MDCK-derived cell line can be prepared by serum-free culture and suspension culture. Preferably, the MDCK-derived cell line has low or no tumorigenicity. The MDCK-derived cell line is preferably selected from MDCK Sky1023, MDCK Sky10234 and MDCK Sky3851. Further disclosed are a culture method for growing the MDCK-derived cells and a method for producing a vaccine virus using the MDCK-derived cells.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: September 20, 2016
    Assignee: SK Chemicals Co., Ltd.
    Inventors: Yong Wook Park, Kun Se Lee, Bong-Yong Lee, Mahnhoon Park, Hun Kim, Yun-Hee Kim, Su-Jeen Lee
  • Patent number: 9447384
    Abstract: The present invention provides an arsenite oxidase enzyme modified to prevent translocation by modification of a translocation signal sequence. A microorganism modified to express the heterologous arsenite oxidase enzyme is also provided by the invention, together with a device for detecting the presence of arsenite in a sample.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: September 20, 2016
    Assignee: The Bio Nano Centre Limited
    Inventors: Anthony Edward George Cass, Joanne Santini, Christopher James Johnson
  • Patent number: 9447385
    Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: September 20, 2016
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Michael G. Bramucci, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
  • Patent number: 9447386
    Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: September 20, 2016
    Assignee: E I DU PONT NEMOURS AND COMPANY
    Inventors: Howard Glenn Damude, Ericka Bermudez, Changjiang Li, Knut Meyer, Keith Roesler, Bo Shen, Mitchell C Tarczynski
  • Patent number: 9447387
    Abstract: Pseudomonas exotoxin A or “PE” is a 66kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as antibodies, to generate therapeutically useful cytotoxin conjugates that selectively target cells of a desired phenotype (such as tumor cells). In the present invention, peptides spanning the sequence of an approximately 38kD form of Pseudomonas exotoxin A protein were analyzed for the presence of immunogenic CD4+ T cell epitopes. Six immunogenic T cell epitopes were identified. Residues were identified within each epitope for introduction of targeted amino acid substitutions to reduce or prevent immunogenic T-cell responses in PE molecules which may be administered to a heterologous host.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: September 20, 2016
    Assignee: INTREXON CORPORATION
    Inventors: Timothy David Jones, Francis Joseph Carr
  • Patent number: 9447388
    Abstract: Provided are various novel DNA polymerases. Provided is a DNA polymerase comprising an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 8 by inserting nine amino acids “-A737-A738-A739-A740-A741-A742-A743-A744-A745-” between the amino acid residue at position 736 and the amino acid residue at position 737, wherein: A737 is an amino acid residue having a non-polar aliphatic side chain; A738 is an amino acid residue having a non-polar aliphatic side chain; A739 is an amino acid residue having a positively charged side chain; A740 is an amino acid residue having a positively charged side chain; A741 is an amino acid residue having a non-polar aliphatic side chain; A742 is an amino acid residue having a non-polar aliphatic side chain; A743 is any given amino acid residue; A744 is an amino acid residue having a positively charged side chain; and A745 is an amino acid residue having a non-polar aliphatic side chain).
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: September 20, 2016
    Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, TAKARA BIO INC.
    Inventors: Yoshizumi Ishino, Takeshi Yamagami, Hiroaki Matsukawa, Takashi Uemori, Takehiro Sagara
  • Patent number: 9447389
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: September 20, 2016
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Patent number: 9447390
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: September 20, 2016
    Assignee: The Regents of the University of California
    Inventors: Isaac S. Carrico, Brian L. Carlson, Peng Wu, Carolyn Bertozzi
  • Patent number: 9447391
    Abstract: The disclosure relates to the field of human genetics, particularly the field of peripheral neuropathy, particularly inherited peripheral neuropathy. Specifically, the disclosure relates to methods and materials to detect hereditary peripheral neuropathy, more particularly autosomal recessive Charcot-Marie-Tooth disease.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: September 20, 2016
    Assignees: VIB VZW, Universiteit Antwerpen
    Inventors: Albena Jordanova, Magdalena Zimon, Jonathan Baets, Peter De Jonghe
  • Patent number: 9447392
    Abstract: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 20, 2016
    Assignee: Novozymes A/S
    Inventors: Steffen Danielsen, Lars Kobberoee Skov, Ricardo Leite, Vincent Laize, M. Leonor Cancela Da Fonseca
  • Patent number: 9447393
    Abstract: The present invention provides a novel phosphatidic acid phosphatase gene. The object of the present invention can be solved by providing a nucleic acid comprising the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 4, or SEQ ID NO: 5; a protein comprising the amino acid sequence set forth in SEQ ID NO: 2; and mutants thereof.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: September 20, 2016
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventor: Misa Ochiai
  • Patent number: 9447394
    Abstract: The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalizing moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: September 20, 2016
    Assignee: Valerion Therapeutics, LLC
    Inventor: Dustin D. Armstrong
  • Patent number: 9447395
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: September 20, 2016
    Assignee: FACTOR BIOSCIENCE INC.
    Inventors: Matthew Angel, Christopher Rohde
  • Patent number: 9447396
    Abstract: According to the present invention, a method for stably accumulating a target protein in plant cells or a plant body, and a transgenic plant in which protein has accumulated, are provided. The method of the present invention is a method for accumulating protein in plant cells, comprising accumulating a target protein or a protein deficient in an N-terminal region of the target protein in vacuoles of myrosin cells present in a multiple mutant, in which myrosin cells deficient in intravacuolar protein are also present in a plant body at locations other than around vascular bundles, by expressing a gene that encodes a target protein having an intracellular membrane system localization signal on the N-terminal and a vacuole localization signal on the C-terminal in the multiple mutant.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: September 20, 2016
    Assignee: HONDA MOTOR CO., LTD.
    Inventors: Yoichi Ogawa, Yasuhiro Kondo, Ikuko Nishimura, Makoto Shirakawa, Haruko Ueda, Tomoo Shimada
  • Patent number: 9447397
    Abstract: The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: September 20, 2016
    Assignee: Danisco US Inc.
    Inventors: Wolfgang Aehle, Piet Van Solingen, Martijn S. Scheffers, Richard R. Bott
  • Patent number: 9447398
    Abstract: The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized cbh2 genes from the organisms Cochliobolus heterostrophus, Gibberella zeae, Irpex lacteus, Volvariella volvacea, and Piromyces sp. in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: September 20, 2016
    Assignee: Stellenbosch University
    Inventors: Riaan Den Haan, Emile Van Zyl
  • Patent number: 9447399
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: September 20, 2016
    Assignee: NOVOZYMES A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Ib Groth Clausen
  • Patent number: 9447400
    Abstract: The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: September 20, 2016
    Assignee: DANISCO US INC.
    Inventors: Richard R. Bott, Thijs Kaper, Bradley Kelemen, Frits Goedegebuur, Ronaldus Wilhelmus Hommes, Slavko Kralj, Paulien Kruithof, Igor Nikolaev, Wilhelmus Antonious Hendricus Van Der Kley, Johannes Franciscus Thomas Van Lieshout, Sander Van Stigt Thans, Gudrun Vogtentanz, Mats Sandgren
  • Patent number: 9447401
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 20, 2016
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Patent number: 9447402
    Abstract: The present invention provides a method for producing recombinant prothrombin. The method comprises: providing a vector DNA into which a gene encoding a tag and a gene encoding prothrombin are incorporated, wherein the tag is selected from the group consisting of MBP, SUMO, and NusA; and expressing a tag fusion type prothrombin in a lepidopteran insect or cultured cells of the lepidopteran insect.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: September 20, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Takahiko Bando, Mutsumi Sugai
  • Patent number: 9447403
    Abstract: The present invention relates to peptides of the enolase protein from Staphylococcus aureus as well as nucleic acid and nucleic acid sequence homologs encoding the peptides. The present invention also relates to a composition, particularly a S. aureus vaccine, comprising one or more of the enolase peptides described herein or a fragment, derivative or variant thereof capable of generating an immune response that induces a protective antibody response or opsonophagocytic activity of human neutrophils for S. aureus. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition of the invention.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: September 20, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Tessie B. McNeely, Leslie Cope, Sharon Smith, Amita Joshi, Irene Pak, Arthur Fridman
  • Patent number: 9447404
    Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 20, 2016
    Assignee: BASF SE
    Inventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabrielle Siedenburg, Juergen Pleiss, Demet Sirim, Silvia Fadenrecht
  • Patent number: 9447405
    Abstract: A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: September 20, 2016
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
  • Patent number: 9447406
    Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine ?-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: September 20, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P Kraus, Tomas Majtan, Erez Bublil
  • Patent number: 9447407
    Abstract: The present invention generally relates to modified substrates such as membranes for use in bioartificial organs, such as bioartificial kidneys, and other applications. Certain aspects are generally directed to a membrane or other substrate modified to facilitate the attachment of cells. In one set of embodiments, the substrate or membrane may be at least partially coated with an adhesive such as 3,4-dihydroxy-L-phenylalanine (DOPA), poly(dopamine), or other adhesive comprising a molecule having a catechol moiety, for example on one side of the membrane or substrate. On at least a portion of the adhesive coated portion of the substrate, a protein may be coated, such as an extracellular matrix protein (for example, a collagen), to which cells such as primary human renal proximal tubule cells may be adhered. Surprisingly, such a dual coating may be used to promote the attachment of such cells to a membrane or other substrate that otherwise may not promote cell adhesion.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: September 20, 2016
    Assignee: Agency for Science, Technology and Research
    Inventors: Daniele Zink, Ming Ni, Jackie Y. Ying
  • Patent number: 9447408
    Abstract: The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells by inhibiting p38 function in the step of somatic cell nuclear reprogramming. The 38 function can be inhibited by bringing an inhibitor selected from the group consisting of (1) a chemical inhibitor of p38 (2) a dominant negative mutant of p38 or a nucleic acid that encodes the same, (3) a nucleic acid selected from the group consisting of siRNAs and shRNAs targeted to p38 and DNAs that encode the same and (4) an inhibitor of p38 pathway into contact with a somatic cell and the like.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: September 20, 2016
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Hidaka Yokota
  • Patent number: 9447409
    Abstract: The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: September 20, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: James Stray, Jason Yingjie Liu, Maxim Brevnov, Jaiprakash Shewale, Allison Holt
  • Patent number: 9447410
    Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: September 20, 2016
    Assignees: ADAPTIMMUNE LIMITED, IMMUNOCORE LIMITED
    Inventors: Bent Karsten Jakobsen, Peter Eamon Molloy, Yi Li, Jonathan Michael Boulter