Patents Issued in November 29, 2016
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Patent number: 9504744Abstract: The present invention concerns methods for the treatment of diffuse large cell lymphoma by administration of an anti-CD20 antibody and chemotherapy. Particular embodiments include the administration of anti-CD20 antibody in combination with chemotherapy comprising CHOP (cyclophosphamide, hydroxydaunorubicin/doxorubicin, vincristine, and prednisone/prednisolone) and/or in combination with a transplantation regimen.Type: GrantFiled: June 20, 2014Date of Patent: November 29, 2016Assignee: Biogen Inc.Inventors: Christine A. White, Antonio J. Grillo-Lopez
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Patent number: 9504745Abstract: Compositions for detecting and/or destroying cancer tumors and/or cancer cells via photodynamic therapy are disclosed, as well as methods of use thereof. The compositions comprise a linking protein or peptide attached to or otherwise physically associated with a carbon nanotube to form a targeted protein-carbon nanotube complex.Type: GrantFiled: December 9, 2013Date of Patent: November 29, 2016Assignee: The Board of Regents of the University of OklahomaInventors: Roger G. Harrison, Jr., Daniel E. Resasco, Luis Filipe Ferreira Neves
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Patent number: 9504746Abstract: A pharmaceutical composition comprising: an active ingredient consisting of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, salt thereof, or solvate of the foregoing; and (i) a compound, a 5% (w/w) aqueous solution or suspension of which has a pH of 8 or more, and/or (ii) silicic acid, salt thereof, or solvate of the foregoing is a highly stable pharmaceutical composition, wherein under humidified and heated storage conditions, the decomposition of said compound is sufficiently reduced, or the gelation on the surface of the pharmaceutical composition is sufficiently inhibited.Type: GrantFiled: April 25, 2013Date of Patent: November 29, 2016Assignee: Eisai R&D Management Co., Ltd.Inventors: Hisao Furitsu, Yasuyuki Suzuki
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Patent number: 9504747Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.Type: GrantFiled: March 7, 2014Date of Patent: November 29, 2016Assignee: Novartis AGInventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura Ellen West, Thomas Zabawa, Junping Zhao
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Patent number: 9504748Abstract: An aqueous dispersion comprises a silicone composition dispersed in an aqueous phase. The silicone composition comprises a product of a reaction of (a) an alkenyl-containing organopolysiloxane having an average per molecule of at least 2 alkenyl groups and (b) an Si H containing siloxane having an average per molecule of at least 2 Si H moieties. The dispersion also comprises a hydrosilylation catalyst, a polymeric film former and a surfactant of molecular weight below 1600. The composition is stabilised in dispersion form by the surfactant dissolved in the aqueous phase and the polymeric film former, and is capable of forming a tacky layer on drying.Type: GrantFiled: July 15, 2013Date of Patent: November 29, 2016Assignee: Dow Corning CorporationInventors: Severine Cauvin, Morgane Le Meur, Jonathan Thill, Xavier Jean-Paul Thomas
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Patent number: 9504749Abstract: Improved medical devices and methods are provided that are implantable at or near a target tissue site beneath the skin of a patient, the medical device comprises an adhesive sheet having a region configured to receive a drug depot, the drug depot disposed within the region of the adhesive sheet and the drug depot having at least one surface configured to release a therapeutically effective amount of the drug over a period of at least one day, wherein the adhesive sheet limits movement of the medical device at or near the target tissue site. In some embodiments, the medical device provided can include an effective amount of at least one analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain, particularly postoperative pain or orthopedic degenerative pathology pain.Type: GrantFiled: September 10, 2015Date of Patent: November 29, 2016Assignee: Warsaw Orthopedic, Inc.Inventor: William F. McKay
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Patent number: 9504750Abstract: Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.Type: GrantFiled: March 25, 2013Date of Patent: November 29, 2016Assignee: ADVANCED BIONUTRITION CORPORATIONInventors: Moti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
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Patent number: 9504751Abstract: A pharmaceutical composition comprising: (a) a medium system, comprising a first component, a second component and a third component, wherein the first component is a phosphate buffered saline, the second component is selected from the group consisting of vegetable oils, animal oils, fatty acids and combinations thereof, and the third component is selected from the group consisting of polyethylene glycol, dimethyl sulfoxide (DMSO), ethanol, polypropylene glycol, polysorbate, polyoxyethylated vegetable oil, ethyl acetate, 2-hydroxyethyl 12-hydroxyoctadecanoate, tocopheryl polyethylene glycol succinate and combinations thereof; and (b) n-butylidenephthalide (BP).Type: GrantFiled: April 24, 2015Date of Patent: November 29, 2016Assignee: EVERFRONT BIOTECH INC.Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin, Yu-Han Chiu
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Patent number: 9504752Abstract: It is intended to provide a sterilizer, an oral cavity sterilizer, a sterilization method, a sterilization apparatus, and a sterilizer evaluation method capable of enhancing a sterilization effect. The sterilizer including hydrogen peroxide and a catalase activity inhibitor containing scutellaria or green tea is brought into contact with a sterilization target. Next, the sterilization target is irradiated with light having a wavelength of 350 nm to 500 nm using a light emitting device formed of a semiconductor laser. By the light irradiation, the hydrogen peroxide is photolyzed to generate hydroxy radicals, and sterilization is achieved by the thus-generated hydroxy radicals.Type: GrantFiled: December 1, 2011Date of Patent: November 29, 2016Assignee: AZ CO., LTD.Inventors: Taro Kanno, Keisuke Nakamura, Hiroyo Ikai, Masahiro Kono, Yoshimi Niwano
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Patent number: 9504753Abstract: The present invention describes nanoprodrugs of non-steroidal anti-inflammatory drug (NSAIDs) and nanoprodrugs of ?-lipoic acid-containing and NSAIDs. These nanoprodrugs have antioxidant properties and stimuli-responsiveness, which can be used to treat various disease conditions.Type: GrantFiled: October 31, 2013Date of Patent: November 29, 2016Assignee: Cedars-Sinai Medical CenterInventors: John S. Yu, Bong Seop Lee
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Patent number: 9504754Abstract: Methods and materials relating to a medicament preparation comprising a curcuminoid component and a euradit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.Type: GrantFiled: March 14, 2014Date of Patent: November 29, 2016Assignee: South Dakota Board of RegentsInventors: Hemachand Tummala, Sunny Kumar
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Patent number: 9504755Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.Type: GrantFiled: November 23, 2015Date of Patent: November 29, 2016Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
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Patent number: 9504756Abstract: The present invention provides Ligand-Drug Conjugates, Drug-Linkers, Linkers, and Ligand-Linker Conjugates comprising a self-stabilizing linker assembly component.Type: GrantFiled: March 13, 2013Date of Patent: November 29, 2016Assignee: Seattle Genetics, Inc.Inventors: Robert Lyon, Svetlana O. Doronina, Timothy Bovee
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Patent number: 9504757Abstract: Provided are a glucagon-like peptide-2 (GLP-2) conjugate containing native GLP-2 or its derivative and an immunoglobulin Fc fragment being covalently linked via a non-peptidyl polymer, wherein the native GLP-2 or its derivative has a thiol group introduced at its C-terminal end, and one end of the non-peptidyl polymer is linked to an amino acid residue of the GLP-2 other than the N-terminal amino group thereof; a method for preparing the GLP-2 conjugate; a pharmaceutical composition comprising the same; and a method for treating or preventing intestinal disease, intestinal injury, or gastrosis by using the same. Since the GLP-2 conjugate of the present invention has a remarkably increased binding affinity to a GLP-2 receptor, it shows a prolonged in vivo half-life and an improved in vivo durability and stability.Type: GrantFiled: December 28, 2012Date of Patent: November 29, 2016Assignee: HANMI SCIENCE CO., LTD.Inventors: Seung Su Kim, Se Young Lim, Sung Youb Jung, Se Chang Kwon
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Patent number: 9504758Abstract: An antibody comprising a GlcNAc—S(A)x substituent is disclosed, wherein S(A)x is a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group, a keto group and an alkynyl group and x is 1, 2, 3 or 4, wherein said GlcNAc—S(A)x substituent is bonded to the antibody via C1 of the N-acetylglucosamine of said GlcNAc—S(A)x substituent, and wherein said N-acetylglucosamine is optionally fucosylated. Also disclosed is an antibody-conjugate, in particular to an antibody-conjugate according to the Formula (20) or (20b), wherein AB is an antibody, S is a sugar or a sugar derivative, D is a molecule of interest, and wherein said N-acetylglucosamine is optionally fucosylated (b is 0 or 1). Also disclosed is a process for the preparation of a modified antibody, to a process for the preparation of an antibody-conjugate, and to said antibody-conjugate for use as a medicament.Type: GrantFiled: July 23, 2015Date of Patent: November 29, 2016Assignee: SynAffix B.V.Inventors: Floris Louis Van Delft, Remon Van Geel, Maria Antonia Wijdeven
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Patent number: 9504759Abstract: An aspect of embodiments of the invention relates to surface modified proteinaceous spherical particles (SMOP). SMOPs according to an embodiment of the invention may comprise a protein layer and an amyloid-binding moiety bound to the protein. In an embodiment, the protein layer is spherical in shape and comprises proteins linked to each other by disulfide bonds. It is suggested that SMOPs are effective in preventing formation of amyloid and aggregation of A? when administered to a patient in need thereof.Type: GrantFiled: August 8, 2012Date of Patent: November 29, 2016Assignee: BAR-ILAN UNIVERSITYInventor: Shai Rahimipour
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Patent number: 9504760Abstract: The present invention relates to a preferably nebulizable pharmaceutical composition comprising a pharmaceutically acceptable protein-based nanocarrier preferably in the size range 150 to 300 nm and a preventative or therapeutic amount of an active agent for use in the prevention and/or treatment of an allergic and/or inflammatory disease of the lower airways in a mammal. Preferably, the active agent is a CpG oligodeoxynucleotide (CpG-ODN), and preferably the composition exhibits a prolonged clinical effect.Type: GrantFiled: March 6, 2012Date of Patent: November 29, 2016Inventors: Sebastian Fuchs, Conrad Coester, Heidrun Gehlen, John Klier, Gerhard Winter
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Patent number: 9504761Abstract: A stabilized chitosan-based nanoparticle is provided having a chitosan polymer and a hydrophilic dispersing agent. In the stabilized nanoparticle, chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network between the chitosan polymer and the hydrophilic dispersing agent. The stabilized chitosan-based nanoparticle has optimal particle integrity and stability properties under physiological conditions.Type: GrantFiled: April 20, 2011Date of Patent: November 29, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventors: Swadeshmukul Santra, James Turkson, Astha Malhotra, Padmavathy Tallury
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Patent number: 9504762Abstract: The invention provides improved adeno-associated virus (AAV) Factor VIII (FVIII) vectors, including AAV FVIII vectors that produce a functional Factor VIII polypeptide and AAV FVIII vectors with high expression activity.Type: GrantFiled: September 10, 2014Date of Patent: November 29, 2016Assignee: BIOMARIN PHARMACEUTICAL INC.Inventors: Peter Cameron Colosi, Amit Nathwani, Jenny Mcintosh, Edward Tuddenham
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Patent number: 9504763Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.Type: GrantFiled: April 19, 2016Date of Patent: November 29, 2016Assignee: AVELAS BIOSCIENCES, INC.Inventors: Jesus Gonzalez, Junjie Liu
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Patent number: 9504764Abstract: Disinfecting method for disinfecting a room or a surface, comprising the steps of: a) providing a fluid comprising at least one organic compound obtainable from natural substances, wherein the organic compound is provided in an non-polar or polar medium, or in a mixture of non-polar and polar media; b) mixing the fluid with a gas such that fluid particles are suspended in the gas, and an aerosol of fluid particles is formed; c) directing a flow of the aerosol formed in step b) on said surface or into said room.Type: GrantFiled: July 9, 2012Date of Patent: November 29, 2016Inventor: Hans Peter Zarfl
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Patent number: 9504765Abstract: The dispensing device comprising an active substance dispensing element (1) and adjustment means of the dispensing of said active substances, said active substance dispensing element (1) being housed inside a casing (2) formed by a first body (3) and a second body (4) that can be coupled to each other and that can rotate with respect to each other, said adjustment means comprising an opening (5) provided in said first body (3) and at least one tab (6), such that the relative position between said first (3) and second (4) bodies determines the degree of closure of said opening (5) by means of said tab (6), and in that said first body (3) comprises holes (7) supplementary to a protrusion (8), the position of said protrusion (8) inside one of said holes (7) determining varying adjustment positions of the degree of closure of said opening.Type: GrantFiled: January 10, 2014Date of Patent: November 29, 2016Assignee: ZOBELE ESPANA, S.A.Inventors: Montserrat Riera Giner, Julio Cesar Ruiz Ballesteros, Cedric Gobber
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Patent number: 9504766Abstract: A blower featuring a hollow casing, a centrifugal fan, a fragrance cartridge, and an air intake grille. The casing has an air inlet and outlet. The centrifugal fan is housed within the casing and contains a rotational motor and a impeller. The impeller is coupled to a motor axle. The air intake grille is housed at the air inlet and can provide a housing for the fragrance cartridge. The fragrance cartridge is removable and can be fixed to the grille by inserting it into the impeller along the axial plane. The blower is easy to use and is able to diffuse fragrances quickly, creating a fragrant atmosphere while promoting air flow.Type: GrantFiled: March 3, 2015Date of Patent: November 29, 2016Assignee: Foshan Naibao Electric Co., Ltd.Inventor: Lifen Tan
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Patent number: 9504767Abstract: The present invention addresses the problem of providing an absorbent article that has an improved ability to transfer menstrual blood from a liquid-permeable layer to an absorbent body and can reduce the amount of the menstrual blood remaining in the liquid-permeable layer. To solve this problem, provided is a sanitary napkin provided with a top sheet, a back sheet and an absorbent body that is interposed between the top sheet and the back sheet, wherein convex portions formed in an excretion orifice contact region of the top sheet are coated with a blood lubricity-imparting agent that has a kinetic viscosity of 0.01-80 mm2/s at 40° C., a water retention rate of 0.01-4.0 mass % and a weight-average molecular weight of less than 1,000.Type: GrantFiled: August 20, 2013Date of Patent: November 29, 2016Assignee: UNICHARM CORPORATIONInventors: Ichiro Wada, Masashi Nakashita, Masashi Uda
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Patent number: 9504768Abstract: A biodegradable material has an improved biodegradability, an enhanced shape recovery rate after deformation of the material and an improved flexibility. The biodegradable material is a chemically cross-linked product of: a multivalent compound A having 3 or more functional groups X such as hydroxyl group; a multivalent compound B having 3 or more functional groups Y such as carboxyl group; and a compound C having a structure originated from a hydroxycarboxylic acid whose homopolymer formed by homopolymerization has a glass transition point of ?40° C. or lower.Type: GrantFiled: March 28, 2013Date of Patent: November 29, 2016Assignee: Toray Industries, Inc.Inventors: Masaki Fujita, Megumi Nakanishi, Kazuhiro Tanahashi
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Patent number: 9504769Abstract: Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.Type: GrantFiled: September 6, 2011Date of Patent: November 29, 2016Assignee: Cook Biotech IncorporatedInventors: Michael C. Hiles, Jason P. Hodde, David M. J. Ernst, Lal Ninan
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Patent number: 9504770Abstract: Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.Type: GrantFiled: June 17, 2015Date of Patent: November 29, 2016Assignee: LifeCell CorporationInventors: Hui Xu, Wenquan Sun, Hua Wan, Rick T. Owens
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Patent number: 9504771Abstract: The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.Type: GrantFiled: May 9, 2011Date of Patent: November 29, 2016Assignee: W. L. Gore & Associates, Inc.Inventors: Robert L. Cleek, Edward H. Cully, Jeffrey B. Duncan, Theresa A. Holland, Thomas R. McDaniel, Christine M. Scotti
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Patent number: 9504772Abstract: The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.Type: GrantFiled: March 10, 2014Date of Patent: November 29, 2016Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Mikael Trollsas, Michael Ngo, Florencia Lim
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Patent number: 9504773Abstract: Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a blood flow conduit while the heart is in systole and expel the blood into the blood flow conduit and the artery while the heart is in diastole.Type: GrantFiled: July 7, 2015Date of Patent: November 29, 2016Inventor: Paul A. Spence
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Patent number: 9504774Abstract: A medical device comprises a pump adapted to fit within an atrium of a heart, said pump comprising an inlet and an outlet. The device further comprises a flexible outflow conduit coupled to said outlet. A method of assisting ventricular function of a heart of a patient comprises: a) inserting a continuous flow pump having an inlet and an outlet into the heart via a subclavian or jugular vein; b) attaching the outlet of the continuous flow pump to an atrial septum, wherein the inlet of the continuous flow pump is directed into a heart atrium; c) attaching the distal end of the outflow conduit to an artery; and d) operating the pump at a volumetric rate ranging from about 2 L/min to about 3 L/min.Type: GrantFiled: October 1, 2008Date of Patent: November 29, 2016Assignee: MINVASC DEVICES, LLCInventors: Oscar H. Frazier, William E. Cohn
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Patent number: 9504775Abstract: A TET system is operable to vary an amount of power transmitted from an external power supply to an implantable power unit in accordance with a monitored condition of the implantable power unit. The amount of power supplied to the implantable power unit for operating a pump, for example, can be varied in accordance with a cardiac cycle, so as to maintain the monitored condition in the power circuit within a desired range throughout the cardiac cycle.Type: GrantFiled: October 15, 2015Date of Patent: November 29, 2016Assignee: HeartWare, Inc.Inventors: Barry M. Yomtov, John Robert Batty
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Patent number: 9504776Abstract: A cannula for moving fluids between a pump and the circulatory system of a patient. The cannula includes a liner having an intermediate portion between a proximal portion and a distal portion, and a lumen extending between the proximal and distal portions. At least the intermediate portion of the liner is constructed from a tissue in-growth material for supporting the growth of endothelial cells. A jacket surrounds at least part of the liner.Type: GrantFiled: February 11, 2011Date of Patent: November 29, 2016Assignee: CircuLite, Inc.Inventors: Robert C. Farnan, Oliver Marseille
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Patent number: 9504777Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.Type: GrantFiled: August 7, 2015Date of Patent: November 29, 2016Assignee: OUTSET MEDICAL, INC.Inventors: Michael Edward Hogard, Gopi Lingam, Dean Hu, Balaji M. Maniam, James Ritson, Andy H. Uchida, John David Stienmier, Paul David McGregor
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Patent number: 9504778Abstract: A dialysis machine includes: a source of dialysis solution; a pump configured to pump the dialysis solution; a heater configured to heat the dialysis solution; an electrical input receiving power from a remote power source; and a housing supporting the pump, the heater and the electrical input, the housing including an electrical insulation rated for 240 VAC such that the remote power source can be either 110 or 240 VAC.Type: GrantFiled: February 6, 2013Date of Patent: November 29, 2016Assignees: Baxter International Inc., Baxter S.A.Inventors: Peter Hopping, Alex Anping Yu
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Patent number: 9504779Abstract: A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.Type: GrantFiled: July 17, 2015Date of Patent: November 29, 2016Assignee: RHEOXTECH, LLCInventors: Neil J. Thomas, Gintaras A. Vaisnys
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Patent number: 9504780Abstract: Systems, methods, and compositions for removing organophosphate toxins from blood are disclosed herein. The compositions include a lipid-based capture particle that displays BChE that binds to the toxin. The methods include acoustically separating toxins bound to lipid-based capture particles from blood factors of whole blood.Type: GrantFiled: January 30, 2014Date of Patent: November 29, 2016Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Tammy Spain, Jason O. Fiering, Leila Albers
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Patent number: 9504781Abstract: Peripheral arterialization devices and methods of using the same. In an exemplary embodiment of a catheter for facilitating venous arterialization of the present disclosure, the catheter comprises an elongated body extending from a proximal end to a distal end and having a lumen defined therethrough along a longitudinal length of the elongated body, the elongated body configured to attach to a graft at or near the proximal end of the elongated body and further configured to permit fluid to flow through the graft, through the lumen, and out of one or more apertures defined within the elongated body at or near the distal end to facilitate venous arterialization upon at least partial implantation of the catheter into a vein of a patient.Type: GrantFiled: November 29, 2013Date of Patent: November 29, 2016Assignee: CVDevices, LLCInventors: Ghassan S. Kassab, Jose A. Navia, Sr.
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Patent number: 9504782Abstract: A plastic package for hydrophilic articles, in particular for hydrophilically coated medical instruments, is intended to ensure the hydrophilic nature of the enclosed instrument over a long period of time. The package includes at least one receiving compartment with a medical instrument for insertion into body tissue and is characterized in that, after sterilization by radiation, it has a proportion of volatile constituents of ?0.1 ?g/cm2.Type: GrantFiled: October 1, 2013Date of Patent: November 29, 2016Assignee: Roche Diabetes Care, Inc.Inventors: Brigitte Niederberger, Volker Zimmer
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Patent number: 9504783Abstract: A fluid dispensing system 3 for dispensing one or more fluids from one or more reservoirs 2 to a patient, the fluid dispensing system comprising a particle filter 13 for preventing particles of a size larger than a predetermined size from being injected into the patient. The invention also relates to a reusable interconnection set 1 comprising a particle filter 13 for use in such a fluid dispensing system 3. The invention also relates to the use of such a fluid dispensing system 3 or reusable interconnection set 1 for dispensing a fluid or contrast fluid to a patient.Type: GrantFiled: June 4, 2012Date of Patent: November 29, 2016Inventor: Jean-Pierre Peters
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Patent number: 9504784Abstract: A multi-channel peristaltic pump in which each channel can be operated independently of the others. A peristaltic pump includes a plurality of motors, each of which drives a rotor shaft which is independently rotatable around an axis and which rotates a roller head having a plurality of rollers. The rotor shafts are disposed in a concentric manner. The peristaltic pump further can include a control system allowing an operator to selectively determine the speed and direction of rotation of each of the roller heads of the pump.Type: GrantFiled: September 15, 2011Date of Patent: November 29, 2016Assignee: Cole-Parmer Instrument Company LLCInventor: Gunay Ozturk
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Patent number: 9504785Abstract: Infusion devices and methods are provided for a drug delivery system and can include an infusion needle (1) having a tip end (2) and a drive unit (D) coupled to the infusion needle and arranged for advancing the tip end of the infusion needle to penetrate any fibrosis when the infusion device is implanted in a patient's body. The infusion needle and drive unit are designed for implantation in a patient's body. Other components of the drug delivery system may be part of the implantable infusion device or, alternatively, be for extracorporal use cooperating with the implanted infusion device. Preferably, the infusion needle can be advanced and retracted with each infusion cycle. Furthermore, upon each advancement and/or retraction, the needle may be moved laterally so as to vary the injection site. Needle (1) and drive unit (D) are preferably disposed within a body (15), with the infusion needle being arranged for penetrating a self-sealing penetration membrane (18).Type: GrantFiled: November 1, 2006Date of Patent: November 29, 2016Inventor: Peter Forsell
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Patent number: 9504786Abstract: A safety shield apparatus is provided that includes a housing that defines a cavity. A distal end of the housing includes a cover having a movable tab. A hub is disposed for movement within the housing and includes a needle having a distal end and a movable projection. The hub is biased between an extended position, such that the distal end of the needle is exposed and the movable projection is releasably disposed with the cavity, and a retracted position whereby the distal end of the needle is disposed within the housing. The movable tab is engageable with the movable projection to release the movable projection from the cavity to facilitate movement of the hub. The distal end of the housing may define a lip that is configured to capture the distal end of the needle. The hub can define an angled distal surface to orient the needle out of axial alignment with the housing and into capture with the lip.Type: GrantFiled: July 1, 2013Date of Patent: November 29, 2016Assignee: Covidien AGInventors: James L. Carlyon, Stephen B. Earhart, Eugene E. Weilbacher
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Patent number: 9504787Abstract: An ambulatory infusion device for the infusion of a liquid drug into a patient's body over an extended time period includes an infusion cannula designed to be placed in the patient's subcutaneous tissue. At least two subcutaneous electrodes are comprised by the infusion cannula and are placed in the subcutaneous tissue. An impedance measuring unit is operatively coupled to the at least two electrodes and is configured to measure at least one impedance value between the at least two electrodes. A variation of the at least one impedance value reflects a displacement of interstitial fluid by drug upon drug administration. An event trigger unit is operatively coupled to the impedance measuring unit and being configured to evaluate the at least one impedance value and to generate an event trigger if evaluation of the at least one impedance value indicates the occurrence of an administration anomaly.Type: GrantFiled: December 18, 2009Date of Patent: November 29, 2016Assignee: Roche Diagnostics International AGInventors: Reto Aeschilimann, James Leuenberger
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Patent number: 9504788Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.Type: GrantFiled: April 5, 2013Date of Patent: November 29, 2016Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Elizabeth A. Sweeney, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Patent number: 9504789Abstract: A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. The blood glucose measurements are separated by a time interval. The method also includes receiving patient information at the data processing device and selecting a subcutaneous insulin treatment from a collection of subcutaneous insulin treatments. The selection is based on the blood glucose measurements and the patient information. The selection includes one or more of a subcutaneous standard program, a subcutaneous program without meal boluses, a meal-by-meal subcutaneous program without carbohydrate counting, a meal-by-meal subcutaneous program with carbohydrate counting, and a subcutaneous program for non-diabetic patients. The method also includes executing, using the data processing device, the selected subcutaneous insulin treatment.Type: GrantFiled: November 12, 2015Date of Patent: November 29, 2016Assignee: Aseko, Inc.Inventors: Robert C. Booth, Harry Hebblewhite
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Patent number: 9504790Abstract: A method and apparatus are provided for locating a target region which is situated in a body of a subject, for example for the delivery of drugs. The system cooperates with a reservoir for receiving an injection fluid, a needle in fluid communication with the reservoir, and a sensor operable to detect a characteristic indicative of the fluid pressure in the needle. A signal generator supplies a success signal to an operator that indicates when the needle is present in the target region. A central controller controls the signal generator in response to signals received from the sensor.Type: GrantFiled: February 23, 2016Date of Patent: November 29, 2016Assignee: MILESTONE SCIENTIFIC, INC.Inventor: Mark N. Hochman
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Patent number: 9504791Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module is user selectable so that it will deliver a priming dose of a primary medicament or both the primary and secondary medicaments. The module also contains a needle guard that locks after dose delivery. The needle guard prevents accidental needle sticks before and after an injection. A locking collar rotates during use as an inner protrusion follows three paths of a track located on the outer surface of a body housing. When the inner facing protrusion is in the third path, it encounters a hard stop and a rotational bias that locks the guard from further refraction and thus covers the sharp distal end of the needle.Type: GrantFiled: March 23, 2011Date of Patent: November 29, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: John David Cross, Malcolm Stanley Boyd, Alasdair George Young, Naceur Rekaya, James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Simon Lewis Bilton
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Patent number: 9504792Abstract: A dispensing apparatus for a flowable component includes a storage container, an applicator and a closure element. The storage container has a storage chamber configured to receive the component, an outlet flange and a component outlet. The applicator has a component inlet and a dispensing opening, and is connected to the storage container by the outlet flange establishing a connection between the component outlet of the storage container and the component inlet of the applicator. The closure element is independent from the applicator, and configured to selectively adopt a closed position and a dispensing position, the component outlet is closed in the closed position and open in the dispensing position, and is configured to be coupled to the applicator so as to be brought from the closed position into the dispensing position by a rotation of the applicator in a connection direction with respect to the storage container.Type: GrantFiled: November 27, 2013Date of Patent: November 29, 2016Assignee: SULZER MIXPAC AGInventor: Marco Müller
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Patent number: 9504793Abstract: A medicament delivery device is presented for the administration of one or more drug agents, wherein the device comprises a retainer for holding a medicament cartridge. The retainer is moveable between an open and closed position. A position sensor for generating a position output is indicative of whether the retainer is in the open or closed position. Further, a cartridge sensor generates a cartridge output indicative of whether the retainer is holding a medicament cartridge. A controller controls a predetermined operation of the device in dependence on the output of the position sensor and on the output of the cartridge sensor.Type: GrantFiled: May 24, 2012Date of Patent: November 29, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Ilona Eggert, Christopher Nigel Langley, Shane Alistair Day, Aled Meredydd James