Abstract: An ultrasonic measuring apparatus includes an ultrasonic transducer device having a substrate and an ultrasonic transducer element array that is arranged on the substrate, a first channel terminal group arranged at one edge portion of the ultrasonic transducer element array in a first direction, a second channel terminal group arranged at the other edge portion of the ultrasonic transducer element array in the first direction, a first flexible substrate provided on the one edge portion side and having arranged thereon a first wiring group that is connected to the first channel terminal group, a first integrated circuit apparatus that is mounted on the first flexible substrate and performs at least one of signal transmission to the first channel terminal group and signal reception from the first channel terminal group, a second flexible substrate provided on the other edge portion side and having arranged thereon a second wiring group that is connected to the second channel terminal group, and a second integra

Abstract: Apparatuses and methods for controlling ionic strength and/or pH of a solution are provided.

Abstract: An injection device comprising: a housing defining a space; a seat located in said space, the seat being configured for receiving a flow path element capable of injecting a pressurized fluid into the injection device through the seat; a pressure source for pressurizing a medium in said space, thereby reducing the pressure difference between the pressurized fluid in said flow path element and said medium.

Abstract: A GC-IMS system is disclosed. The system includes a sample transfer device. The sample transfer device connects the gas chromatograph to the reaction region and, the sample from the gas chromatograph is transferred to the reaction region by the sample transfer device. With the GC-IMS system, generation of sample molecular ion fragments can be avoided so that the spectrum is easily identified; moreover, the application field of the GC-IMS system is extended to a range of analysis of organic macromolecule samples which have a high polarity, are difficult to volatilize, and are thermally instable. On the other hand, the GC-IMS system overcomes the defect of ion destruction due to neutralization reaction among positive and negative ions so as to evade the detection.

Abstract: A reactor capable of near absolute catalytic conversion of at least one alternative compound containing a specified moiety into a select compound containing the specific moiety, and an analytical instrument employing the reactor. The reactor including a catalytic element configured and arranged for fluid contact with a test fluid and a reactant, with at least 90% of the surface area of the catalytic element located within a thermal target zone in the reaction chamber of the reactor.

Abstract: This invention is to make it possible for the analysis system to conduct the minimum operation of the management device or monitoring a movement of the analysis device continuously while preventing an unexpected operation by an unauthorized user. In order to attain this object, the access level is automatically changed to the smaller operable range in case that the operation conducted based on a certain access level is interrupted for a certain period of time.

Abstract: A display device on a container cover includes a substrate, a driving circuit unit on the substrate, a display element unit on the driving circuit unit, a sealing member on the display element unit, and a coupling portion to a container body.

Abstract: An egg identification system for determining viability of an avian egg is provided. Such a system includes an emitter assembly configured to emit electromagnetic radiation toward an egg. A detector assembly is axially aligned with the emitter assembly to detect electromagnetic radiation transmitted through the egg. The detector assembly is spaced-apart from the egg during operation thereof such that the detector assembly does not contact the egg. The detected electromagnetic radiation is processed using transmission spectroscopy analysis to determine whether the egg is viable. An associated method is also provided.

Abstract: An object of the present invention is to provide a moisture measuring apparatus which, when the body of the apparatus for measuring a state of moisture in a measurement target object is mounted into the measurement target object, provides a user with a mounting state as to whether the moisture measuring apparatus has been appropriately mounted. In the present invention, the CPU of a moisture measuring apparatus determines the mounting state of the moisture measuring apparatus in soil that is a measurement target object (judges whether or not there is a gap between a sensor electrode and soil) based on the state of moisture (moisture amount) measured by a soil moisture amount sensor, and informs a result of the judgment.

Abstract: As system for measuring drilling fluid properties includes a capillary rheometer that is adapted to measure viscosity parameters of drilling fluid. The capillary rheometer includes a feed chamber, the feed chamber having a cavity, at least a first drain port for draining fluid out of the cavity, a double wall defining an annulus that opens to the cavity, and a feed port in an outer portion of the double wall that is in fluid communication with the annulus. The capillary rheometer also includes at least a first capillary tube coupled to at least the first drain port. Additionally, the disclosed system further includes a pump that is adapted to pump fluid to the feed port.

Abstract: A method for determining a salt concentration of a hydrocarbon fluid using a conductivity sensor and a hydrocarbon testing solution includes forming the hydrocarbon testing solution. The electropolymerizable monomer is operable to form a resultant associated polymer at a peak potential of the electropolymerizable polymer. The method includes introducing the hydrocarbon testing solution into the conductivity sensor. The method includes inducing a range of potential across the hydrocarbon testing solution such that at least a portion of the electropolymerizable monomer polymerizes. The range of induced potential includes the peak potential of the electropolymerizable polymer. The method includes detecting a range of electrical current associated with the range of potential induced. The method also includes the step of determining the salt concentration of the hydrocarbon fluid using the range of potential induced and the range of electrical current detected.

Abstract: There is provided a method for determining Total Acid Number (TAN) in a fluid fossil fuel, such as a crude oil, comprising: separating said fluid fossil fuel by liquid chromatography into a plurality of fractions, comprising at least one acidic fraction; determining boiling point distribution of said crude oil, of said acidic fraction, and of said polyacidic fraction by simulated distillation (SD); and correlating said boiling point distributions to acid molecular weights to determine the TAN.

Abstract: A system and a process for detecting early stage electrical components problems with an analysis system is disclosed. The system process includes determining an oil quality of the oil of an electrical component using the analysis system. The system the process further including determining dissolved gases in the oil of the electrical component using the analysis system, processing and analyzing the oil quality and the dissolved gases using the analysis system, and determining whether there are problems in the electrical component using the analysis system.

Abstract: Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.

Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.

Abstract: An air sampler device has a top plate and a bottom plate, and receives a Petri dish between the top plate and the bottom plate. The top plate includes 283 substantially small holes. The bottom plate has a deepened center well formed in the top surface. Elongated slots are formed in the top surface which extend out from the well. The slots have distal ends which extend beyond the Petri dish. Air is drawn into the sampler by a vacuum tube through an air port which communicates with the center well. Air is pulled into the 283 holes in the top plate and strikes the capture material in the Petri dish. The air then travels up over the sides of the dish, into the distal ends, through the slots, and into the center well, where it exits out of the vacuum air port.

Abstract: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.

Abstract: A biological barrier model is disclosed. In some embodiments the barrier may be configured to model the blood brain barrier. The model may include a membrane having one or more cell cultures disposed thereon. The cells cultures may be grown in the presence of shear stress induced by flow through the device in some embodiments. The size of the barrier, as well as the distance to electrodes and other sensors, may be in the microscale range. Further, in some embodiments the model may comprise an array of parallel channels and membranes.

Abstract: The invention provides methods, compositions, devices, and kits relating to the use of cholesterol-dependent cytolysins (e.g., PFOs) for measuring intracellular mitochondrial activity.

Abstract: Provided are a sample analyzer and sample analyzing method capable of performing proper and efficient analysis by fitting measurement items of a sample to the patient. A sample analyzer 1 obtains a patient ID and measurement order from a laboratory host 10 based on the sample ID read from a barcode label T1 of a sample container T via a barcode reader B1, and the measurement items of the obtained measurement order are recorded in a work list. The sample analyzer 1 also prepares revised measurement items based on past measurement results corresponding to the obtained patient ID. The sample analyzer 1 replaces the measurement items of the work list with the revised measurement items when the revised measurement items satisfy predetermined conditions, and measures and analyzes the sample according to the replacement measurement items.

Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided.

Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.

Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.

Abstract: The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL. Another aspect of the invention pertains to therapeutic compositions directed to gene expression and gene products of differentially expressed genes in LGL. The invention also concerns methods for screening and identifying compositions that may be of therapeutic benefit to patients having LGL leukemia and/or autoimmune disorders. In addition, because a large fraction of patients with T-LGL leukemia also have rheumatoid arthritis, these differentially expressed genes also represent novel targets for the diagnosis, prevention or treatment of rheumatoid arthritis and other autoimmune diseases.

Abstract: High affinity monoclonal antibodies against Stx2f and hybridomas that produce such antibodies are described. The antibodies may be used in a kit for detecting Stx2f and variants thereof in a sample as well as neutralization of Shiga toxin in vivo.

Abstract: The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments.

Abstract: The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments.

Abstract: In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO:2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) the amino acid corresponding to position 1610 of SEQ ID NO: 2 is mutated from N to C; and (iii) the amino acids corresponding to Q1624 to R1641 of SEQ ID NO: 2 are deleted.

Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A density-altering agent may be added to a vessel that contains the sample to change the density of a non-target material.

Abstract: Provided is a method for diagnosing cancer by detecting a novel cancer marker. Cancer can be diagnosed by detecting soluble glypican 3 in a test sample.

Abstract: Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies show a number of novel and useful diagnostic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to normal pancreatic tissues and binding to a high percentage of early stage pancreatic cancers. In preferred embodiments, the antibodies bind to pancreatic cancer mucins. The antibodies and fragments are of use for the detection and diagnosis of early stage pancreatic cancer. In preferred embodiments, the anti-pancreatic cancer antibodies can be used for immunoassay of serum samples, wherein the immunoassay can detect a marker for early stage pancreatic cancer in serum. More preferably, the serum is extracted with an organic phase, such as butanol, before immunoassay.

Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.

Abstract: The present invention provides a method for detecting an interaction, which method can solve not only the problem of false negatives but also the problem of false positives.

Abstract: The present invention relates to a method for the production of a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 as well as a method for selecting from a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 one or more of said derivatives having a specific binding affinity to a protein or peptide.

Abstract: Provided herein are methods for evaluating the effect of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof in a patient with an assay based on UVB-irradiation and phosphorylated c-Jun expression. The analyzes allow for evaluation of dose-response and identification of patient populations who are sensitive to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof.

Abstract: Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health and disease status and to assess the risk of developing a disease or condition. Methods for detecting the presence of oncofetal fibronectin indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided. Methods and products for detection of oncofetal fibronectin for selection of concept are provided.

Abstract: Disclosed are apparatuses for detecting hemoglobin in patient samples. The apparatuses include a primary electrode and a reference electrode. The apparatus is configured to measure current or voltage generated between the primary electrode and the reference electrode in response a redox reaction catalyzed by hemoglobin. The apparatuses can detect a variety of hemoglobins, including dimeric hemoglobin associated with malaria. Also disclosed are biosensor systems including the apparatuses and methods of using the biosensor systems.

Abstract: This invention relates to non-surgical assays that can be used to determine whether an animal that has a non-postpartum anestrous period of three months or greater, such as a dog or a cat, has been spayed. In particular, the present invention relates to devices, kits and methods that allow correlation of levels of Anti-Müllerian Hormone with the state of being spayed.

Abstract: An in vitro method for the risk stratification of patients with stable arteriosclerosis, especially stable coronary artery disease, is disclosed wherein the concentration of procalcitonin is determined in the circulation of such patients using a highly sensitive PCT assay, and wherein within the range of PCT concentrations in the typical normal range of healthy individuals cutoff values are defined which distinguish groups of individual patients with stable arteriosclerosis in accordance with personal cardiac risk, and patients are allotted to one of said risk groups on the basis of their individual PCT concentrations.

Abstract: The automatic analyzer includes: a first reagent container storage section storing a plurality of reagent containers; a regent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage section; a second reagent container storage section storing a plurality of reagent containers; a reagent container transfer mechanism for transferring a reagent container selected from among reagent containers stored in the second reagent container storage section to the first reagent container storage section; and a controller configured to control the reagent container transfer mechanism to transfer a reagent container from the second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.

Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.

Abstract: An automatic analysis apparatus according to an embodiment incudes a dispensing probe, a cleaning unit, and a driving mechanism. The dispensing probe performs a dispensing operation for sucking a sample and discharging the sample into a reaction container. The cleaning unit cleans the dispensing probe. The cleaning unit includes a first cleaning position at which the dispensing probe is cleanable using a first cleaning liquid, and a second cleaning position which is located at a position lower than the first cleaning position and at which the dispensing probe is cleanable using a second cleaning liquid. The driving mechanism stops the dispensing probe at at least one of the first cleaning position and the second cleaning position.

Abstract: A sensor arrangement for a vehicle includes a sensor unit, a cable arrangement, and an elastic cap. The sensor unit has a main support, an electronics part connected to the main support, and a sensor element. The cable arrangement has at least one individual wire, and is configured to electrically contact the electronics part via at least one contact-making member. The main support is an open housing defining at least one insertion opening configured to accommodate the at least one contact-making member and an accommodation pocket configured to at least partially accommodate the electronics part. The elastic cap has a member configured to fasten the sensor unit in the vehicle, is configured to be pushed at least partially over the main support, and closes off the accommodation pocket in a sealed manner.

Abstract: A device for measuring the speed of movement of a wheeled terrestrial vehicle. A magnetometer takes measurements of an ambient terrestrial magnetic field and is positioned so as to be sensitive to the magnetic field variations caused by the rotation of at least one partially metallic wheel of the vehicle. The magnetometer delivers a corresponding signal. The signal is processed to establish a frequency spectrum thereof. From the frequency spectrum, a frequency of rotation of the wheel is determined, and deducing therefrom, on the basis of information representative of the radius of the wheel, the speed of movement of the vehicle.

Abstract: The present invention relates to an apparatus for measuring a muzzle velocity of a fired bullet so that the bullet may explode at an accurate location. The muzzle velocity measuring apparatus includes a detector configured to comprise a pair of cores encircled by probe wound coils and installed in two separate positions in an adapter, and to output a muzzle velocity signal based on eddy current signals which are generated by the probe wound coils when a bullet fired from a bullet chamber passes through the adapter, a muzzle velocity calculator configured to calculate a flight speed of the fired bullet based on the muzzle velocity signal; and a transmitter configured to transmit the calculated flight speed to the bullet.

Abstract: An inertia sensor includes a sensor element including first and second sensing parts configured to output first and second sensing signals, an amplifier having an input port to which the first sensing signal or the second sensing signal is selectively input, a feedback circuit unit configured to be connected between the input port and the output port of the amplifier to be connected in parallel to the amplifier, a first switching element provided between the first sensing part and the amplifier, a second switching element provided between the first sensing part and the feedback circuit unit, a third switching element provided between the second sensing part and the amplifier, and a fourth switching element provided between the second sensing part and the feedback circuit unit. This inertia sensor, stabilizes output characteristics of the amplifier circuit, and suppresses generation of unwanted signals.

Abstract: A z-axis micro-electro-mechanical detection structure, having a substrate defining a plane and a suspended mass carried by two anchorage elements. The suspended mass includes a translating mass, suspended over the substrate, mobile in a transverse direction to the plane and arranged between the anchorage elements and two tilting masses, each of which is supported by the anchorage elements through respective elastic anchorage elements so as to be able to rotate with respect to respective oscillation axes. The oscillation axes are parallel to each other to enable a translation movement of the translating mass. Fixed electrodes face at a distance the tilting masses or the translating mass so as to be able to detect displacement of the suspended mass as a result of external forces. Elastic supporting elements are arranged between the translating mass and the tilting masses to enable relative rotation between the translating mass and the tilting masses.

Abstract: Briefly, in accordance with one or more embodiments, a method to test one or more sensors of a device under test may comprise capturing visual motion data of the device under test disposed on an arm of a pendulum apparatus while the arm of the pendulum apparatus is in motion, capturing data from the one or more sensors while the arm of the pending apparatus is in motion, and comparing the visual motion data with the data from the one or more sensors to determine a relationship between the visual motion data and the data from the one or more sensors.

Abstract: A method for inspecting an electronic device, in which inspection of electrical characteristics is carried out, uses conduction to pass a current to an electronic device while the electronic device is being continuously conveyed.

Abstract: Circuit boards are provided that include a functional portion and at least one removable test point portion. The removable test point portion may include test points which are accessed to verify whether the functional portion is operating properly or whether installed electronic components are electrically coupled to the board. If multiple boards are manufactured together on a single panel (in which the individual boards are broken off), the test points can be placed on bridges (e.g., removable portions) that connect the individual boards together during manufacturing and testing. Configurable test boards are also provided that can be adjusted to accommodate circuit boards of different size and electrical testing requirements. Methods and systems for testing these circuit boards are also provided.