Patents Issued in December 13, 2016
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Patent number: 9517977Abstract: The present invention relates to compounds of the formula (I), to mixtures of the said compounds with emitter compounds, to the use of compounds of the formula (I) and the said mixtures in electronic devices, and to electronic devices containing one or more compounds of the formula (I) and/or mixtures of compounds of the formula (I) with emitter compounds.Type: GrantFiled: October 1, 2010Date of Patent: December 13, 2016Assignee: Merck Patent GmbHInventors: Hubert Spreitzer, Jochen Schwaiger, Heinrich Becker
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Patent number: 9517978Abstract: A process for chilling ethylene to required storage temperatures is disclosed, the process including: cooling an ethylene product from at least one of an ethylene production process and an ethylene recovery process via indirect heat exchange with a coolant at a temperature less than about ?100° C. to decrease the temperature of the ethylene product; mixing a portion of the cooled ethylene product with methane to form the coolant; expanding at least one of the coolant, the methane, and the portion of the cooled ethylene to reduce a temperature of the coolant to less than ?100° C. prior to the cooling; and feeding the heat exchanged coolant to at least one of the ethylene production process, the ethylene recovery process, and an open-loop refrigeration system.Type: GrantFiled: September 21, 2015Date of Patent: December 13, 2016Assignee: Lummus Technology Inc.Inventor: Stephen De Haan
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Patent number: 9517979Abstract: A process for producing para-xylene (PX) comprises supplying a hydrocarbon feed comprising xylenes and ethylbenzene (EB) to a PX recovery unit, where a PX-rich stream and at least one PX-depleted stream are recovered from the feed. The PX-depleted stream is then separated into an EB-rich stream and an EB-depleted stream in a divided wall column. The EB-depleted stream is then isomerized under at least partial liquid phase conditions to produce a first isomerized stream having a higher PX concentration than the PX-depleted stream, and the EB-rich stream is isomerized under at least partial vapor phase conditions to produce a second isomerized stream having a higher PX concentration than the PX-depleted stream. The first and second isomerized streams are then recycled to the PX recovery unit to recover additional PX and the process is repeated to define a so-called xylene isomerization loop.Type: GrantFiled: December 15, 2015Date of Patent: December 13, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Timothy P. Bender, John R. Porter, Dana L. Pilliod
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Patent number: 9517980Abstract: The present invention is an improved process and apparatus for producing para-xylene, particularly with respect to a process that involves the methylation of toluene and/or benzene to selectively produce para-xylene, wherein streams having differing amounts of ethylbenzene are separately treated in the recovery of para-xylene. A first hydrocarbon feed comprising xylenes and ethylbenzene is provided to a first para-xylene adsorption section, and a second hydrocarbon feed comprising xylenes and less EB than the first hydrocarbon feed is provided to a second para-xylene adsorption section. Segregating the feeds with differing ethylbenzene contents increases the overall efficiency of the adsorption of para-xylene by the adsorption units. Efficiency and energy savings may be further improved by subjecting the lower-content ethylbenzene stream to liquid phase isomerization.Type: GrantFiled: December 15, 2015Date of Patent: December 13, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Robert G. Tinger, Dana L. Pilliod, Michel Molinier
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Patent number: 9517981Abstract: Gas separation processes are provided for separating dehydrogenation reaction products from a raw gas stream to recover hydrocarbons, specifically olefins, such as propylene and iso-butene, as well as unreacted feedstock. The processes employ a sequence of partial condensation steps, interspersed with membrane separation steps to raise the hydrocarbon dewpoint of the uncondensed gas, thereby avoiding the use of low-temperature or cryogenic conditions.Type: GrantFiled: December 6, 2013Date of Patent: December 13, 2016Assignee: Membrane Technology and Research, Inc.Inventors: Nicholas P. Wynn, Alvin Ng, Douglas Gottschlich, Paul Su, Meijuan Zhou, Sylvie Thomas-Droz
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Patent number: 9517982Abstract: Split-shell fractionation columns and associated processes for separating aromatic hydrocarbons are provided by using, a split-shell fractionation column includes a housing shell having a first height and a partition having a second height and disposed within the housing shell. The partition includes first and second vertically oriented baffles separated by a gap region, a seal plate connecting top ends of the baffles, a first input port formed to extend through the partition for the introduction of a gas into the gap region, and a first output port formed to extend outwardly from a bottom of the gap region and through the housing shell. The partition defines a first distillation zone and a second distillation zone within the housing shell.Type: GrantFiled: October 10, 2014Date of Patent: December 13, 2016Assignee: UOP LLCInventors: Jason T. Corradi, David William Ablin
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Patent number: 9517983Abstract: A process is disclosed for removing contaminants from an olefin stream, comprising passing the contaminated olefin stream through a first adsorbent in a thermal swing adsorption process to produce a relatively pure olefin product stream, and a regenerating gas stream containing the contaminants, passing the contaminated regenerating gas stream through a pressure swing adsorption process to yield a relatively pure regenerating gas stream, which can be redirected to the thermal swing adsorption process for regenerating the adsorbent therein.Type: GrantFiled: July 16, 2014Date of Patent: December 13, 2016Assignee: BASF CORPORATIONInventor: William Dolan
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Patent number: 9517984Abstract: Embodiments of an integrated method for step-wise conversion of 2,3-butanediol to 2-butanol, and optionally to hydrocarbons, are disclosed. The method includes providing an acidic catalyst, exposing a composition comprising aqueous 2,3-butanediol to the acidic catalyst to produce an intermediate composition comprising methyl ethyl ketone, providing a hydrogenation catalyst that is spatially separated from the acidic catalyst, and subsequently exposing the intermediate composition to the hydrogenation catalyst to produce a composition comprising 2-butanol. The method may further include subsequently exposing the composition comprising 2-butanol to a deoxygenation catalyst, and deoxygenating the 2-butanol to form hydrocarbons. In some embodiments, the hydrocarbons comprise olefins, such as butenes, and the method may further include subsequently exposing the hydrocarbons to a hydrogenation catalyst to form saturated hydrocarbons.Type: GrantFiled: April 3, 2015Date of Patent: December 13, 2016Assignee: Battelle Memorial InstituteInventors: Michael A. Lilga, Guo-Shuh Lee, Suh-Jane Lee
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Patent number: 9517985Abstract: The invention relates to a method for producing butanol through microbial fermentation, in which the butanol product is removed by extraction into a water immiscible organic extractant during the fermentation. The invention also relates to a method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible extractant composition. The invention further relates to compositions comprising a solution of butanol in a water immiscible organic extractant composition.Type: GrantFiled: March 14, 2014Date of Patent: December 13, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Thomas Basham, Leslie William Bolton, Ian David Dobson, Sarah Richardson Hanson, Aidan Hurley, Karen Kustedjo, Andrew Richard Lucy, Liang Song
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Patent number: 9517986Abstract: A process for preparing a 2,2?-biphenol, proceeds by a) adding a first phenol to a reaction mixture, b) adding a second phenol to the reaction mixture, c) adding selenium dioxide to the reaction mixture, d) adding an acid having a pKa in the range from 0.0 to 5.0 to the reaction mixture, and e) heating the reaction mixture such that the first phenol and the second phenol are converted to said 2,2?-biphenol.Type: GrantFiled: May 22, 2015Date of Patent: December 13, 2016Assignee: Evonik Degussa GmbHInventors: Katrin Marie Dyballa, Robert Franke, Dirk Fridag, Siegfried R. Waldvogel, Thomas Quell, Michael Mirion
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Patent number: 9517987Abstract: A method for the selective synthesis of bisphenols, thermosetting resins, and thermoplastics from salicylic acid, the major component of wintergreen oil, and a viable target for engineered biosynthesis. Condensation of salicylic acid, structural analogs of salicylic acid, and derivatives of salicylic acid with short chain aldehydes or ketones and subsequent decarboxylation has the potential to produce bisphenols that are direct replacements for conventional resins, while the steric and electronic effects of salicylic acid improve the efficiency and selectivity of the conversion process. The utilization of renewable polyphenols as precursors to epoxies, poly carbonates, and high temperature thermosets including cyanate esters, provides an opportunity to develop full-performance resins while reducing the use of petroleum based feedstocks. This approach will then diminish the overall environmental impact of resin production while allowing for a sustainable source of phenols.Type: GrantFiled: April 21, 2015Date of Patent: December 13, 2016Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Benjamin G. Harvey, Heather A. Meylemans, Michael E. Wright, Andrew Chafin
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Patent number: 9517988Abstract: The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a cocrystal thereof, a preparation method thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of the central nervous system; wherein the definitions of substituents in general formula (A) are the same as those in the Description.Type: GrantFiled: November 9, 2015Date of Patent: December 13, 2016Assignee: Sichuan Haisco Pharmaceutical Co., Ltd.Inventors: Linlin Qin, Fangqiong Li, Shixu Yi, Huadong Luo, Xinfeng Luo, Songlin Wan, Lei Ren, Guoliang Liu, Yonggang Wei, Jianyu Liu, Peng Cho Tang
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Patent number: 9517989Abstract: The present invention relates to novel 2-cycloalkyl resorcinol compounds; to pharmaceutical compositions comprising the compounds; and to methods of preparing the compounds and uses thereof. The disclosed compounds can bind to and modulate the cannabinoid receptors and thus, they are specific ligands for these receptors. The invented compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response may be useful to treat a number of physiological conditions.Type: GrantFiled: October 17, 2013Date of Patent: December 13, 2016Assignee: NORTHEASTERN UNIVERSITYInventors: Alexandros Makriyannis, Marsha R. D'Souza, Shama Bajaj, Spyridon P. Nikas, Ganeshsingh A. Thakur
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Patent number: 9517990Abstract: A negative dielectric anisotropic liquid crystal compound containing 2,3-difluorophenyl, and a preparation method and use thereof are disclosed. The compound has a general structural formula as shown in Formula I. The negative dielectric anisotropic liquid crystal compound has a negative dielectric anisotropy (??), and has cyclobutyl or cyclopentyl as a terminal group. Compared with conventional liquid crystal compounds with a flexible alkyl chain as a terminal group, the compound of Formula I according to the present invention has the advantage of high clearing point, and enables extension of the application range of a liquid crystal mixture because a positive correlation exists between the clearing points of the liquid crystal mixture and monomer liquid crystal compounds. In addition, the compound can increase the absolute value of the negative dielectric constant of the liquid crystal mixture, thus having an important application value.Type: GrantFiled: November 19, 2013Date of Patent: December 13, 2016Assignee: Shijiazhuang Chenzhi Yonghua Display Materials Co., Ltd.Inventors: Guoliang Yun, Ruimao Hua, Kui Wang, Zefeng Hou, Lei Zhao, Gang Wen, Lianbo Mao
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Patent number: 9517991Abstract: A process for preparing 2-methylbutanal from the secondary streams obtained in the preparation of mixtures of isomeric ?,?-unsaturated decenals, characterized in that a) a mixture comprising linear butenes is reacted in the presence of transition metal compounds of group VIII of the Periodic Table of the Elements with carbon monoxide and hydrogen at elevated temperature and elevated pressure to give a pentanal mixture; b) the pentanal mixture obtained in step a) is converted in the presence of basic compounds to a mixture of isomeric ?,?-unsaturated decenals; and c) the mixture obtained in step b) is separated into a stream enriched with unconverted 2-methylbutanal and a stream enriched with a mixture of isomeric ?,?-unsaturated decenals; with the proviso that the stream which has been separated off in step c) and is enriched with unconverted 2-methylbutanal is reacted with formaldehyde.Type: GrantFiled: November 14, 2014Date of Patent: December 13, 2016Assignee: OXEA GMBHInventors: Jens Theuerkauf, Heinz Strutz
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Patent number: 9517992Abstract: Branched optionally unsaturated ketones particularly useful in providing typical and characteristic orris facets to perfume compositions.Type: GrantFiled: March 15, 2013Date of Patent: December 13, 2016Assignee: Givaudan S.A.Inventor: Philip Kraft
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Patent number: 9517993Abstract: Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are disclosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll-like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.Type: GrantFiled: July 29, 2013Date of Patent: December 13, 2016Assignee: The Regents of the University of Colorado, a body corporateInventors: Hang Yin, Kui Cheng
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Patent number: 9517994Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1-R3 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.Type: GrantFiled: January 7, 2013Date of Patent: December 13, 2016Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Juan Shen
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Patent number: 9517995Abstract: A process for preparing isomeric hexanoic acids comprising 2-methylpentanoic acid from the secondary streams obtained in the preparation of pentanals, characterized in that a) a mixture comprising linear butenes is reacted to give a pentanal mixture; b) the mixture obtained in step a) is separated into a stream enriched with 2-methylbutanal and 3-methyl-butanal, and a stream enriched with n-pentanal; c) the stream enriched with 2-methylbutanal and 3-methylbutanal of step b) is reacted with formaldehyde; d) the reaction mixture obtained after step c) is selectively reacted to give a mixture comprising 2-methylbutanal and isomeric hexanals; e) the reaction mixture is separated into a stream enriched with 2-methylbutanal and a stream enriched with a mixture of isomeric hexanals; and f) the mixture of isomeric hexanals obtained in step e) is oxidized to a mixture of isomeric hexanoic acids comprising 2-methylpentanoic acid.Type: GrantFiled: November 14, 2014Date of Patent: December 13, 2016Assignee: OXEA GMBHInventors: Jens Theuerkauf, Heinz Strutz
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Patent number: 9517996Abstract: A process for purifying a polycarboxylic acid from a mixture is provided. Optionally, the mixture is an aqueous solution and optionally the process comprises an acidification step and/or the use of one or more organic solvents. Also provided in part are compositions of polycarboxylic acids.Type: GrantFiled: June 12, 2015Date of Patent: December 13, 2016Assignee: Verdezyne, Inc.Inventors: Jose Laplaza, William Andrew Evanko, Jason H. Radany
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Patent number: 9517997Abstract: This disclosure relates to a method of continuous recovery of (meth)acrylic acid and an apparatus used for the continuous recovery method. The continuous recovery method of (meth)acrylic acid according to the present invention may maintain a recovery rate of (meth)acrylic acid equivalent to that of the previous recovery method, and yet may significantly reduce energy consumption, and may minimize polymerization of (meth)acrylic acid in the recovery process, thus providing more improved operation stability.Type: GrantFiled: July 9, 2013Date of Patent: December 13, 2016Assignee: LG Chem, Ltd.Inventors: Se-Won Baek, Jong-Hun Song, Sul-Hee Yoo
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Patent number: 9517998Abstract: A method of making, separating, and purifying artepillin C in propolis includes mixing propolis with ethanol to obtain a propolis-ethanol extract; providing supercritical carbon dioxide and the propolis-ethanol extract to a chromatographic column to separate wax, artepillin C, and flavonoids; providing supercritical carbon dioxide, the artepillin C, and the flavonoids to an adsorption column to remove the flavonoids; keeping the adsorption column still; and providing ethanol to the adsorption column to obtain the purified artepillin C.Type: GrantFiled: December 11, 2015Date of Patent: December 13, 2016Inventor: Ming-Hsi Chuang
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Patent number: 9517999Abstract: A process for producing a grade of (meth)acrylic acid having residual formaldehyde levels of under 100 parts per million.Type: GrantFiled: March 7, 2014Date of Patent: December 13, 2016Assignee: Rohm and Haas CompanyInventors: Alan E. Sopchik, Stephen T. Cohn
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Patent number: 9518000Abstract: The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.Type: GrantFiled: March 13, 2014Date of Patent: December 13, 2016Assignee: Bristol-Myers Squibb CompanyInventors: Yan Shi, Peter T. W. Cheng, Ying Wang, Shung C. Wu, Hao Zhang
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Patent number: 9518001Abstract: A composition comprising about 97 mole percent or greater of one or more 1,1-dicarbonyl substituted-1-ethylenes and about 3 mole percent or less of one or more 1,1-dicarbonyl substituted-methanes. A process comprising: contacting in a fluid state one or more 1,1-dicarbonyl substituted-1,1 hydroxymethyl-methanes and greater than 200 ppm to about 1000 ppm of one or more strong acids based on the weight of the one or more 1,1-dicarbonyl substituted-1,1 hydroxymethyl-methanes with a zeolite catalyst at a temperature of about 180° C. to about 220° C. for a sufficient time to convert about 96 percent or greater of the one or more 1,1-dicarbonyl substituted-1,1 hydroxymethyl-methanes to one or more 1,1-dicarbonyl substituted-1-ethylenes.Type: GrantFiled: May 19, 2016Date of Patent: December 13, 2016Assignee: SIRRUS, INC.Inventors: Jeffrey M. Sullivan, Kevin Powers, William Barrett
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Patent number: 9518002Abstract: Methods of carrying out metathesis reactions of natural oil-derived polyenes (e.g., dienes and trienes), including functionalized polyenes, are generally disclosed herein. In some embodiments, the dienes or trienes contain a terminal carbon-carbon double bond, and the metathesis reaction is selective toward reaction of the terminal carbon-carbon double bonds in the polyene. Compounds made by such methods are also generally disclosed herein.Type: GrantFiled: October 19, 2015Date of Patent: December 13, 2016Assignee: Elevance Renewable Sciences, Inc.Inventors: Keith M. Wampler, Jane Uy, Steven A. Cohen
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Patent number: 9518003Abstract: Two methods of producing high purity dimethyl carbonate through the reaction of carbon dioxide and methanol are provided. In the ammonia-based method ammonia and carbon dioxide react to produce urea. The urea is mixed with methanol for further reaction to produce dimethyl carbonate. Ammonia released in the process is recycled as a reactant to produce more urea. In the ethylene-oxide process carbon dioxide reacts with ethylene oxide to produce ethylene carbonate. It is then reacted with methanol to produce dimethyl carbonate with ethylene glycol as byproduct. An integrated reactive distillation process using side reactors is used for facilitating catalytic reaction in these two methods for producing high purity dimethyl carbonate. The process is further enhanced by enclosing multiple side reactors into a pressure vessel and incorporating thermal heat pump for recovery and reuse of latent heat within the process.Type: GrantFiled: July 29, 2014Date of Patent: December 13, 2016Assignee: E3TEC Service, LLCInventors: Chandrakant B. Panchal, John C. Prindle
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Patent number: 9518004Abstract: A reduced coenzyme Q10 derivative represented by formula (1), wherein R1 and R2 are each independently H or an alkoxycarbonyl group represented by formula (2), and at least one of them is an alkoxycarbonyl group represented by the formula (2); in the formula (2), R3 is an optionally substituted linear, branched, or cyclic alkyl group having 1 to 20 carbon atoms, an optionally substituted aryl group having 6 to 20 carbon atoms, or an optionally substituted heteroaryl group having 4 to 20 carbon atoms, and when R3 is a group substituted with polyethylene glycol, the molecular weight of the polyethylene glycol is not more than 300.Type: GrantFiled: December 2, 2013Date of Patent: December 13, 2016Assignee: KANEKA CORPORATIONInventors: Teruyoshi Koga, Yoshihisa Okamoto, Takao Yamaguchi
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Patent number: 9518005Abstract: Processes are disclosed for the conversion of a carbohydrate source to hexamethylenediamine (HMDA) and to intermediates useful for the production of hexamethylenediamine and other industrial chemicals. HMDA is produced by direct reduction of a furfural substrate to 1,6-hexanediol in the presence of hydrogen and a heterogeneous reduction catalyst comprising Pt or by indirect reduction of a furfural substrate to 1,6-hexanediol wherein 1,2,6-hexanetriol is produced by reduction of the furfural substrate in the presence of hydrogen and a catalyst comprising Pt and 1,2,6-hexanediol is then converted by hydrogenation in the presence of a catalyst comprising Pt to 1,6 hexanediol, each process then proceding to the production of HMDA by known routes, such as amination of the 1,6 hexanediol. Catalysts useful for the direct and indirect production of 1,6-hexanediol are also disclosed.Type: GrantFiled: April 15, 2015Date of Patent: December 13, 2016Assignee: Rennovia Inc.Inventors: Eric L. Dias, James A. W. Shoemaker, Thomas R. Boussie, Vincent J. Murphy
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Patent number: 9518006Abstract: The invention relates to an industrial-scale method for the vapor-phase hydrogenation of dinitrotoluene (DNT). According to said method, a stream containing DNT is sprayed into a carrier-gas stream containing hydrogen, optionally in the presence of an atomizing gas, unevaporated liquid droplets are extracted from the substantially gaseous stream that is obtained and the resultant gas stream is catalytically hydrogenated to form diaminotoluene.Type: GrantFiled: October 2, 2014Date of Patent: December 13, 2016Assignee: Covestro Deutschland AGInventors: Bernd Pennemann, Amgad Salah Moussa, Bastian Mahr
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Patent number: 9518007Abstract: The present invention provides a thermosetting resin which enables the production of a carbon fiber reinforced plastic having a good workability and excellent mechanical properties by hand lay up (HUP) molding, resin transfer molding (RTM) or vacuum assisted resin transfer molding (VaRTM). The urethane (meth) acrylate compound (A) according to the present invention is an urethane (meth) acrylate produced by reacting a compound having two or more isocyanate groups with a monoalcohol compound containing ethylenically unsaturated groups or by reacting a compound having two or more isocyanate groups with a monoalcohol compound containing ethylenically unsaturated groups and an alcohol compound having two or more hydroxyl groups, said urethane (meth) acrylate compound (A) being characterized by having an isocyanate group and ethylenically unsaturated groups.Type: GrantFiled: January 15, 2014Date of Patent: December 13, 2016Assignee: JAPAN U-PICA COMPANY, LTD.Inventors: Tetsuji Moroiwa, Nozomi Ishine, Hiroshi Hayashi
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Patent number: 9518008Abstract: The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.Type: GrantFiled: October 10, 2014Date of Patent: December 13, 2016Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A., ChinaInventors: Song Li, Wu Zhong, Zhibing Zheng, Xinbo Zhou, Junhai Xiao, Yunde Xie, Lili Wang, Xingzhou Li, Guoming Zhao, Xiaokui Wang, Hongying Liu
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Patent number: 9518009Abstract: The present invention provides a compound of the formula (I): wherein: R2 and R3 represent each independently a hydrogen atom or a hydrocarbon group; A represents an s-valent organic group; and s is an integer of 2-10. This nitrileoxide compound has stable and can be easily produced.Type: GrantFiled: March 6, 2015Date of Patent: December 13, 2016Assignees: DAIKIN INDUSTRIES, LTD., TOKYO INSTITUTE OF TECHNOLOGYInventors: Tadashi Kanbara, Tsuyoshi Noguchi, Haruhisa Masuda, Haruhiko Mouri, Toshikazu Takata, Satoshi Uchida, Yasuhito Koyama, ChenGang Wang, Shunsuke Monjiyama, Hiromitsu Sogawa
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Patent number: 9518011Abstract: An object of the present invention is to provide a recording material or a recording sheet using, as a color-developing agent, a non-phenol compound that is a safe compound in no danger of corresponding to an endocrine disruptor and is good in color developing performance. The non-phenol compound used in the present invention is at least one selected from the group consisting of compounds represented by the following formulas (I) to (III).Type: GrantFiled: November 19, 2013Date of Patent: December 13, 2016Assignee: NIPPON SODA CO., LTD.Inventors: Hiroshi Sakai, Tadahiro Kondo, Kayoko Tada, Shuntaro Kinoshita, Kazumi Jyujyo
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Patent number: 9518012Abstract: Disclosed herein is a method of preparing a Cu/Cu2O core-shell copper nanoparticle catalyst having high catalytic activity from [Cu3(BTC)2] and NaBH4 via a simple chemical reduction method. Also disclosed is a method of preparing a chalcogenide compound by using the nanoparticle catalyst as a heterogeneous catalyst in a cross-coupling reaction between a chalcogenide precursor compound and a boron-containing compound. The disclosed cross-coupling reaction is performed via a simple process, and the disclosed nanoparticle catalyst is compatible with various substrates under mild reaction conditions and exhibits excellent recyclability without a reduction in catalytic activity.Type: GrantFiled: September 23, 2015Date of Patent: December 13, 2016Assignee: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATIONInventors: Kang Hyun Park, Sung Kyun Park, Bu Hyun Youn, Jin Kyoon Park, Jung Sub Lee, Balaji Mohan, Seong Wan Jang, Sang Geun Lee, Cho Hye Yoon
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Patent number: 9518013Abstract: The present invention relates generally to peroxyformic acid forming compositions, methods for forming peroxyformic acid, preferably in situ, using the peroxyformic acid forming compositions. The present invention also relates to the peroxyformic acid formed by the above compositions and methods. The present invention further relates to the uses of the peroxyformic acid, preferably in situ, for treating a surface or a target. The present invention further relates to methods for treating a biofilm using peroxyformic acid, including peroxyformic acid generated in situ.Type: GrantFiled: December 17, 2015Date of Patent: December 13, 2016Assignee: Ecolab USA Inc.Inventors: Junzhong Li, Allison Brewster, Richard Staub, Steven J. Lange, Taz Cheritu, Jonathan P. Fast
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Patent number: 9518014Abstract: A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of ?-arylamino ?-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of ?-arylamino ?-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.Type: GrantFiled: January 29, 2013Date of Patent: December 13, 2016Assignee: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Kuiling Ding, Xiaoming Wang, Zheng Wang
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Patent number: 9518015Abstract: The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.Type: GrantFiled: September 14, 2012Date of Patent: December 13, 2016Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.Inventors: Antoni Torrens Jover, Ramon Mercè Vidal, Francesc Xavier Caldentey Frontera, Antonio David Rodríguez Garrido, Elena Carceller González, Jordi Salas Solana
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Patent number: 9518016Abstract: The present disclosure relates to novel compounds, compositions containing same and methods for treating or preventing a condition associated with a deficient insulin secretion such as diabetes and metabolic syndrome in a subject in need thereof.Type: GrantFiled: May 20, 2016Date of Patent: December 13, 2016Assignee: VAL-CHUM, LIMITED PARTNERSHIPInventors: Murthy Madiraju, Marc Prentki, Erik Joly
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Patent number: 9518017Abstract: The present invention is directed to a method of separating a monocarboxylic represented by the following structural formula: (I) from a dicarboxylic acid represented by the following structural formula: (II) using silica chromatography.Type: GrantFiled: June 26, 2014Date of Patent: December 13, 2016Assignee: ImmunoGen, Inc.Inventor: Wayne C. Widdison
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Patent number: 9518018Abstract: 3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinic acids having a halogen, alkyl or mono-, di-tri- and tetra-substituted aryl substituents in the 6-position, and their acid derivatives, are herbicides demonstrating a broad spectrum of weed control.Type: GrantFiled: April 29, 2014Date of Patent: December 13, 2016Assignee: Dow AgroSciences LLCInventors: Jeffrey B. Epp, Christian T. Lowe, James M. Renga, Paul R. Schmitzer, Joseph D. Eckelbarger, Katherine A. Guenthenspberger, Thomas L. Siddall, Carla N. Yerkes, Lindsey G. Horty, Natalie C. Giampietro, Jeremy Kister, Joshua Roth
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Patent number: 9518019Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C1-C4 alkyl propiolate and a substituted methylene amine by a series of steps.Type: GrantFiled: February 10, 2016Date of Patent: December 13, 2016Assignee: Dow AgroSciences LLCInventors: Natalie C. Giampietro, James M. Renga
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Patent number: 9518020Abstract: The present invention provides processes for the preparation of i) Regorafenib (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, BAY 73-4506, Stivarga®) and its pharmaceutically acceptable salt thereof; ii) a crystalline solid of Regorafenib tosylate; iii) Regorafenib Polymorph I from Regorafenib tosylate, and iv) a pure 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide from 4-amino-3-fluorophenol and 4-chloro-N-methylpicolinamide in the presence of potassium tert-butoxide.Type: GrantFiled: September 29, 2014Date of Patent: December 13, 2016Assignee: Hetero Research FoundationInventors: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Dasari Muralidhara Reddy, Thungathurthy Srinivasa Rao, Bandi Vamsi Krishna
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Patent number: 9518021Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: GrantFiled: April 25, 2014Date of Patent: December 13, 2016Assignee: JANSSEN PHARMACEUTICA NVInventors: Diego Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Patent number: 9518022Abstract: This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.Type: GrantFiled: December 15, 2015Date of Patent: December 13, 2016Assignee: Prosetta Antiviral Inc.Inventors: Andy Atuegbu, Dennis Solas, Clarence R. Hurt, Anatoliy Kitaygorodskyy
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Patent number: 9518023Abstract: Lactamium based ionic liquids and methods of making them are described. The ionic liquids comprise at least one of: the reaction product of a lactam compound having a general formula wherein the ring has at least one C?C double bond, or and a Brønsted acid HX; or a Brønsted acid HX where X is a halide, and a metal halide.Type: GrantFiled: May 6, 2014Date of Patent: December 13, 2016Assignee: UOP LLCInventors: Erin M. Broderick, Alakananda Bhattacharyya, Alan B. Levy, Lihao Tang
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Patent number: 9518024Abstract: The present disclosure provides a method for preparing a caprolactam and the method includes steps of subjecting cyclohexanone oxime and sulfuric acid to a Beckmann rearrangement reaction to obtain a rearrangement mixture; neutralizing the rearrangement mixture and extracting the neutralized rearrangement mixture using an organic solvent sequentially; and subjecting the extracted organic solution to a hydrogenation reaction so as to simplify the process to produce a high quality caprolactam.Type: GrantFiled: January 15, 2016Date of Patent: December 13, 2016Assignee: China Petrochemical Development CorporationInventors: Yung-Shun Kung, Jih-Dar Hwang, Yao-Ching Tsai
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Patent number: 9518025Abstract: The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives.Type: GrantFiled: November 10, 2014Date of Patent: December 13, 2016Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFTInventors: Sergii Pazenok, Mark James Form, Arnd Neeff
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Patent number: 9518026Abstract: The present disclosure is generally directed to compositions and methods for treating apicomplexan protozoan related disease, such as toxoplasmosis and cryptosporidiosis.Type: GrantFiled: May 20, 2014Date of Patent: December 13, 2016Assignee: University of Washington Through its Center For CommercializationInventors: Erkang Fan, Wesley C. Van Voorhis, Zhongsheng Zhang, Wenlin Huang, Kayode K. Ojo
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Patent number: 9518027Abstract: The present invention in one embodiment provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.Type: GrantFiled: January 8, 2014Date of Patent: December 13, 2016Assignee: Concert Pharmaceuticals, Inc.Inventor: Robert Silverman