Patents Issued in December 15, 2016
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Publication number: 20160363540Abstract: Provided herein is an apparatus, including a light source configured to illuminate a surface of an article. In addition, the apparatus includes a light detector array. The light detector array includes a number of light sensors configured to simultaneously receive scattered light from features about the entire surface. The light detector array is configured to provide information for qualitatively and quantitatively characterizing the features.Type: ApplicationFiled: August 23, 2016Publication date: December 15, 2016Inventors: Joachim W. Ahner, S. Keith McLaurin
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Publication number: 20160363541Abstract: In accordance with an embodiment, an inspection apparatus includes an irradiating section, a detecting section and a control section. The irradiating section is configured to irradiate a sample with light. The detecting section is configured to detect the light reflected by the sample. The control section is configured to classify defects of the sample on the basis of a difference between a first signal outputted from the detecting section by irradiating the sample with the light under a first optical condition and a second signal outputted from the detecting section by irradiating the sample with the light under a second optical condition different from the first optical condition.Type: ApplicationFiled: January 22, 2016Publication date: December 15, 2016Applicant: Kabushiki Kaisha ToshibaInventor: Kiminori YOSHINO
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Publication number: 20160363542Abstract: Inspection of microelectronic devices is described using near infrared light. In one example, a dielectric material layer on a substrate is illuminated with a near infrared light beam. The substrate has at least one contact land, the dielectric material layer overlies at least a portion of the contact land, and the substrate has at least one via defined in the dielectric material layer, the via exposing at least a portion of the contact land. Reflected near infrared light is reflected from the substrate at a camera. The position of the via is determined relative to the contact land from the reflected light beam using an image processing device.Type: ApplicationFiled: August 24, 2016Publication date: December 15, 2016Applicant: Intel CorporationInventors: Liang W. Zhang, Zhihua Zou, Osborne A. Martin, III, Robert F. Wiedmaier
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Publication number: 20160363543Abstract: An automated high-speed method for inspecting metal around fasteners and a computer-controlled apparatus for performing that inspection method. The apparatus comprises a multi-motion inspection head mounted on a scanning bridge, a robotic arm, or a robotic crawler vehicle. The multi-motion inspection head comprises a millimeter waveguide probe and a motorized multi-stage probe placement head that is operable for displacing the waveguide probe along X, Y and Z axes to achieve multiple sequenced motions. The waveguide probe is attached to a mandrel that is rotatably coupled to an X-axis (or Y-axis) stage for rotation about the Z axis. Smart servo or stepper motors with feedback control are used to move the waveguide probe into place and then scan across or around a fastener head to inspect for cracks that may be under paint.Type: ApplicationFiled: June 12, 2015Publication date: December 15, 2016Applicant: The Boeing CompanyInventors: Gary E. Georgeson, Steven K. Brady, Donald D. Palmer, JR.
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Publication number: 20160363544Abstract: In an X-ray inspecting apparatus, a rotational fluctuation amount of a stage is calculated around a power transmission part of the stage and a stage drive unit as a base point, i.e., the X-axis and Y-axis sliding parts, in accordance with detected positional information from a position detecting sensor. Then, a stage shift amount is calculated in accordance with the rotational fluctuation amount and a distance between the base point and an imaging position on the stage. Here, the stage shift amount corresponds to a positional deviation of the stage at the imaging position caused by an attitude variation of the stage in a yawing direction, and thus is an error in repeated positioning. Accordingly, a tomographic image with high resolution can be generated in consideration of the error in repeated positioning.Type: ApplicationFiled: June 9, 2015Publication date: December 15, 2016Inventors: Yusuke TAGAWA, Hiroshi OOHARA, Yoshihiro UENO
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Publication number: 20160363545Abstract: A method for estimating the effective atomic number of a material from a transmission spectrum of said material in which a likelihood function of the effective atomic number and the thickness of the material is calculated on the basis of the transmission spectrum as well as calibration spectra obtained in a previous calibration phase for a plurality of samples of calibration materials of known effective atomic numbers and known thicknesses. The effective atomic number of the material is then estimated on the basis of values of the likelihood function.Type: ApplicationFiled: December 9, 2014Publication date: December 15, 2016Applicant: Commissariat A L'Energie Atomique Et Aux Energies AlternativesInventors: Alexia GORECKI, Jean RINKEL
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Publication number: 20160363546Abstract: Example systems and methods to optimize and integrate of thermal and structural analyses are described herein. An example method includes performing a thermal analysis of a component using a first mesh representing the component to produce a thermal distribution across the component. The first mesh has first nodes based on a first element size. The example method includes using a first mapping file to assign temperature values to second nodes of a second mesh representing the component based on the thermal distribution. The second nodes are based on a second element size different than the first element size. The example method also includes performing a structural analysis of the component using the second mesh and the assigned temperature values to produce gauge sizes for the component and using a second mapping file to assign gauge values to the first nodes of the first mesh based on the gauge sizes.Type: ApplicationFiled: June 10, 2015Publication date: December 15, 2016Inventors: Omid B. Nakhjavani, Mohammad Ali Heidari, Milan Stefanovic, Bradley A. Olmstead, Eric John Zimney, Naveena Mallikarjunaiah
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Publication number: 20160363547Abstract: The invention relates to methods and systems for measuring the melting point of a material. The method and systems of the invention may reduce the time required to determine the melting point of one or more samples. Furthermore, the methods and systems of the invention result in an accurate and precise measurement of the melting temperature. Thus, the method and system of the invention are preferred over current methods for measuring the melting point.Type: ApplicationFiled: February 25, 2015Publication date: December 15, 2016Inventors: Sally Stevens LLOYD, Roger Letts DAWKINS
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Publication number: 20160363548Abstract: Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.Type: ApplicationFiled: June 24, 2016Publication date: December 15, 2016Applicant: Malvern Instruments IncorporatedInventors: Martin BROGA, Phillip PRICE, Stephen SMITH
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Publication number: 20160363549Abstract: In one general aspect, an apparatus can include a probe including an exterior probe element including a first plurality of links defining a first flexible element. The exterior probe element can define a guard ring. The probe can also include an interior probe element including a second plurality of links defining a second flexible element and disposed within at least a portion of a perimeter defined by the exterior probe element. The apparatus can also include a waveform generator electrically coupled to the exterior probe element and the interior probe element.Type: ApplicationFiled: June 14, 2016Publication date: December 15, 2016Inventors: Brian A. MAZZEO, William S. GUTHRIE, Jared BAXTER, Jeffrey D. BARTON
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Publication number: 20160363550Abstract: A system is described that obtains a sample (e.g., a biological fluid sample, a gas sample) and provides data to the person by way of a mobile electronic device. The system can include a mobile detection or measurement device having a sensor configured to receive at least a portion of a fluid sample and a wireless transmitter or transceiver configured to transmit information associated with electrical signals received from the sensor, where the electrical signals are at least partially attributable to one or more analytes in the fluid sample. The system can further include a mobile electronic device in communication with the mobile detection or measurement device. The mobile electronic device may include a short-range wireless transceiver configured to receive the information from the mobile detection or measurement device.Type: ApplicationFiled: August 23, 2016Publication date: December 15, 2016Inventors: Ronald B. Koo, Henry Grage
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Publication number: 20160363551Abstract: An applied voltage control device is used for a sensor, in which a direct current corresponding to an oxygen amount flows when a DC voltage is applied to the sensor, and an alternating current corresponding to a sensor impedance flows when an AC voltage is applied to the sensor. The applied voltage control device includes: a filtering unit that sets a cutoff frequency of the AC voltage applied to the sensor variable.Type: ApplicationFiled: May 10, 2016Publication date: December 15, 2016Inventor: Koji MORISHITA
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Publication number: 20160363552Abstract: A sensor detects the presence of an electrically conductive liquid such as water or the material at the bottom of a reservoir such as an oil pan or crank case. The water or other material will enter a gap between two contacts that are connected to a power source and a signal device such as an LED. The power source may be a battery positioned within the sensor or may be external.Type: ApplicationFiled: August 24, 2016Publication date: December 15, 2016Applicant: L&W Reserves LLCInventors: William J. Jackson, Benny J. Webber, Jesse J. Juarez
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Publication number: 20160363553Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.Type: ApplicationFiled: June 15, 2016Publication date: December 15, 2016Applicant: Purdue Research FoundationInventors: Alina Alexeenko, Andrew Strongrich
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Publication number: 20160363554Abstract: A moisture sensor for drying grain having a sensor block with built in ground bars, a removable electronic module having a circuit board encased in black potting compound, and a removable back plate.Type: ApplicationFiled: June 11, 2015Publication date: December 15, 2016Inventor: Graham Giddings
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Publication number: 20160363555Abstract: A flexible sensor patch includes a flexible base having outer and inner surfaces and a periphery, an adhesive layer disposed on at least a portion of the outer surface, a flexible porous cover secured to the flexible base along at least major portion of the periphery. The flexible porous cover and the flexible base collectively enclose at least a major portion of a sensor. The sensor comprises a capacitive sensor element. The capacitive sensor element comprises first and second conductive electrodes and a dielectric microporous material disposed therebetween. Methods of using the flexible sensor patch are also disclosed.Type: ApplicationFiled: February 19, 2015Publication date: December 15, 2016Inventors: Myungchan Kang, Stefan H. Gryska, Michael C. Palazzotto
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Publication number: 20160363556Abstract: A system of inspecting a focus ring is provided. The system includes a measuring device, a transfer device and an operation unit. The measuring device includes a base substrate, a sensor chip and a circuit board. The sensor chip has a sensor electrode and is provided along an edge of the base substrate. The circuit board is configured to output a high frequency signal to the sensor electrode and acquire a digital value indicating electrostatic capacitance based on a voltage amplitude in the sensor electrode. The transfer device is configured to scan the measuring device. The operation unit is configured to obtain difference values by performing a difference operation with respect to the digital values acquired by the measuring device at multiple positions along a direction which intersects with an inner periphery of the focus ring.Type: ApplicationFiled: June 10, 2016Publication date: December 15, 2016Inventors: Kippei Sugita, Tomohide Minami
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Publication number: 20160363557Abstract: An amperometric gas sensor for measuring the concentration of an analyte includes: a solid configured as an insulator without being contacted by the analyte and configured for diffusion of the analyte therethrough, the solid including a non-conductive polymer, the solid further configured to increase in electrical conductivity when in contact with the analyte; a working electrode positioned on and in contact with the solid; and a reference electrode positioned on and in contact with the solid, the reference electrode spaced apart and insulated from the working electrode without the solid being contacted by the analyte, the working electrode and the reference electrode configured to measure electrical conductivity of the solid when the solid is in contact with the analyte.Type: ApplicationFiled: August 25, 2016Publication date: December 15, 2016Inventors: Elizabeth H. Schenk, Peter A. Burke, Michael A. Centanni
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Publication number: 20160363558Abstract: Proteins that are electrophoretically separated in a gel are derivatized to produce fluorescent emissions by incorporating halo-substituted organic compounds into one or both of the electrode buffer solutions at the two ends of the gel. The halo-substituted compounds used are ones that bear an electric charge at the pH of the buffer solutions and gel, and the polarity of the charge on the compounds is such that the compounds migrate from the electrode buffer into the gel under the electrophoretic influence concurrently with the migration of the proteins into the gel. Once the proteins are separated and distributed within the gel and the gel is fully penetrated with the halo-substituted compounds, the gel is irradiated with ultraviolet light to induce a reaction between the halo-substituted compounds and the proteins through the tryptophan residues on the proteins, producing fluorescent reaction products.Type: ApplicationFiled: August 24, 2016Publication date: December 15, 2016Inventor: Christopher Belisle
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Publication number: 20160363559Abstract: A capillary ionic transistor and method of using is disclosed. The method including providing a capillary pipette (100) having an inner surface defining a channel, and a conductive layer disposed (102) about electrode the channel; filling at least a portion of the channel with an ionic solution (110) such that an electrical double layer forms on the inner surface of the pipette; inducing an electric potential within the ionic solution sufficient to generate a longitudinal flow of ions within the channel; and inducing an electric potential in the conductive layer sufficient to alter the zeta potential of the electrical double layer and adjust the flow of ions within the ionic solution.Type: ApplicationFiled: February 26, 2015Publication date: December 15, 2016Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Yauheni Rudzevich, Yuqing Lin, Lee Chow
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Publication number: 20160363560Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.Type: ApplicationFiled: January 29, 2014Publication date: December 15, 2016Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Jian Zhang, Zane Hammoud
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Publication number: 20160363561Abstract: A method of measuring a property of a medium using ultrasound, comprising: transmitting one or more ultrasound pulses into the medium from one or more transmitters and receiving at least a first echo signal and a second echo signal from within the medium at one or more receivers, wherein the first and second echo signals correspond to first and second pulse transmission paths within the medium from the one or more sources to the one or more receivers, the second path being different from the first path; and using the characteristics of the first and second echo signals together with an estimate of the property of the medium and a geometrical relationship between the first and second transmission paths to calculate a revised estimate of said property of the medium. By using two different beam paths within the medium, the first and second echoes will have had slightly different interactions with the medium.Type: ApplicationFiled: February 26, 2015Publication date: December 15, 2016Inventor: Tormod SELBEKK
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Publication number: 20160363562Abstract: According to one implementation, an ultrasonic test system includes at least one ultrasonic transducer, at least one ultrasonic sensor and a damage detection part composed of at least circuitry. The at least one ultrasonic transducer transmits an ultrasonic wave toward at least one test region. The at least one ultrasonic sensor detects the ultrasonic wave which has passed through the at least one test region. The damage detection part is configured to detect whether there is a damage in the at least one test region, based on a difference between a waveform corresponding to the ultrasonic wave detected by the at least one ultrasonic sensor and a reference waveform. The at least one ultrasonic transducer and the at least one ultrasonic sensor are disposed at positions which apart from each other with an interval longer than 300 mm.Type: ApplicationFiled: June 7, 2016Publication date: December 15, 2016Applicant: FUJI JUKOGYO KABUSHIKI KAISHAInventors: Kohei TAKAHASHI, Hideki SOEJIMA
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Publication number: 20160363563Abstract: A photoacoustic microscope apparatus includes a light source that emits excitation light which generates photoacoustic waves, an objective lens which focuses the excitation light on a specimen, a scanning unit which moves a focused position of the excitation light on the specimen, a photoacoustic-wave detecting unit which has a sensor unit that detects a photoacoustic wave generated, and an image constructing unit which constructs an image based on data from the photoacoustic-wave detecting unit. For the sensor unit, an angle of a range which is capable of receiving the photoacoustic wave incident on the sensor unit is larger than an angle corresponding to a numerical aperture on a side illuminated of the objective lens.Type: ApplicationFiled: August 26, 2016Publication date: December 15, 2016Applicant: OLYMPUS CORPORATIONInventor: Ikutoshi FUKUSHIMA
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Publication number: 20160363564Abstract: To heat a flowing liquid, an apparatus includes a heater block assembly having a heater block made of thermally conductive material. The heater block assembly has a tube inlet, a tube outlet, and a tube path between the tube inlet and tube outlet. Tubing extends through the tube path from the tube inlet to the tube outlet. The tubing is in thermal communication with the heater block. A heater cartridge, in thermal communication with the heater block, is configured to provide heat to the heater block for transfer to liquid flowing through the tubing between the tube inlet and the tube outlet of the heater block assembly. Circuitry is in electrical communication with the heater cartridge to control a temperature of the heater block by controlling operation of the heater cartridge.Type: ApplicationFiled: August 29, 2016Publication date: December 15, 2016Inventors: Peter Kirby, Tony A. Lin, Steven D. Trudeau
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Publication number: 20160363565Abstract: Described are extraction columns and systems that include extraction columns. The extraction column includes a column body that has a reservoir portion, an extraction media portion, and a collar portion. The reservoir portion includes an inlet and a reservoir. The extraction media portion includes an elongated sleeve having an inner surface defining a cavity. The extraction media portion has an inlet end in fluid communication with the reservoir and an outlet end. An extraction medium is disposed in the cavity of the elongated sleeve. The collar portion extends axially in a common direction with the elongated sleeve. The collar portion has a terminal end which is spaced apart from the outlet end of the elongated sleeve and which extends axially at least to a plane defined by the outlet end of the elongated sleeve.Type: ApplicationFiled: June 10, 2015Publication date: December 15, 2016Inventors: Joni Rannisto, Kelly Flook, Leena Valmu, Ville Saarainen, Suvi Ravela, Johan Finell
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Publication number: 20160363566Abstract: A detector arrangement to be scaled or adapted in a simple manner depending on the application includes n·m (n?2, m?2) thermal conductivity detectors that are each arranged in a mounting on a detector block having a high thermal conductivity, wherein each case m detector block is secured radially symmetrically and spaced apart from one another on a carrier having a central opening, forming a detector module, and n detector modules are located on a common axis by the central openings of the carriers.Type: ApplicationFiled: June 3, 2016Publication date: December 15, 2016Inventor: Thomas NEUHAUSER
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Publication number: 20160363567Abstract: A method is disclosed comprising receiving a sample in an analysis chamber, vaporizing one or more vaporizable stressor materials to create a vapor, exposing the sample to the vapor to create a test sample, collecting measurement data from a sensor regarding the test sample, analyzing the measurement data to determine an analysis result, and displaying the analysis result.Type: ApplicationFiled: June 15, 2016Publication date: December 15, 2016Inventor: Jonathan Seamus Blackley
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Publication number: 20160363568Abstract: A fluid separation system for separating compounds of a sample fluid in a mobile phase comprises a detector adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal on the optical stimulus signal. The detector comprises a light source adapted to provide an output light beam as the optical stimulus signal. The light source comprises a plurality of light emitting elements each adapted to emit a light beam having a respective wavelength, and a diffracting element. The plurality of light emitting elements are arranged that emitted light beams impinging on the diffracting element in a respective angle dependent on the respective wavelength are diffracted by the diffracting element into the output light beam.Type: ApplicationFiled: August 19, 2016Publication date: December 15, 2016Inventors: Kevin P. Killeen, Hubert Kuderer, Karsten Kraiczek
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Publication number: 20160363569Abstract: Analysis of chemically samples using gas chromatography (GC) separation with vacuum ultra-violet spectroscopy detection is described. One technique focuses on assigning a specific analysis methodology to each constituent in a sample. Constituents can elute from the GC by themselves or with other constituents, in which case a deconvolution is done using VUV spectroscopic data. In an exemplary embodiment, each constituent may be specifically included in an analysis method during a setup procedure, after which the same series of analyses are done on subsequent sample runs. The second approach essentially integrates an entire chromatogram by first reducing it into a series of analysis windows, or time slices, that are analyzed automatically. The analysis at each time slice determines the molecular constituents that are present as well as their contributions to the total response. Either approach can be used to quantify specific analytes or to do bulk classification.Type: ApplicationFiled: June 7, 2016Publication date: December 15, 2016Inventors: Phillip Walsh, Dale A. Harrison, Sean H. Jameson, JR.
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Publication number: 20160363570Abstract: A method is disclosed comprising drawing vapor from a vapor device, exposing the drawn vapor to a sensor, determining a condition of the drawn vapor via the sensor, collecting data related to the condition of the drawn vapor from the sensor, comparing the collected data to standardized vapor device output data, determining a calibration result based on the comparison, determining a configuration adjustment based on the calibration result, and transmitting the configuration adjustment to the vapor device.Type: ApplicationFiled: June 11, 2016Publication date: December 15, 2016Inventor: Jonathan Seamus Blackley
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Publication number: 20160363571Abstract: A simulation system for simulating particulate matter emissions of an engine is provided. The simulation system comprises a soot generator and an exhaust assembly. The soot generator generates soot. The exhaust assembly is positioned downstream to the soot generator in an exhaust flow direction. The exhaust assembly includes a primary diluter, a catalytic stripper, at least one secondary diluter, a residence chamber, and a tail pipe, which are positioned sequentially in the exhaust flow direction. Components of the exhaust assembly are in fluid communication with the other components positioned upstream or downstream to them. The tail pipe includes a first sample port and a second sample port. The first sample port is fluidly connected to a reference measuring instrument and the second sample port being connected to a particulate measuring instrument.Type: ApplicationFiled: August 23, 2016Publication date: December 15, 2016Applicant: Caterpillar Inc.Inventor: Radhakrishnan Purushothaman
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Publication number: 20160363572Abstract: A method is disclosed comprising exposing air to a sensor, collecting data from the sensor regarding one or more constituents in the air, analyzing the data to determine an analysis result, and displaying the analysis result.Type: ApplicationFiled: June 14, 2016Publication date: December 15, 2016Inventor: Jonathan Seamus Blackley
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Publication number: 20160363573Abstract: A non-methane total hydrocarbons analysis apparatus and method are introduced. The analysis apparatus includes a six-pass valve, quantification ring, first stored gas pipe, second stored gas pipe, multi-pass valve, molecular sieve filling pipe, first air source, and detector. The six-pass valve and the multi-pass valve are configured to have a load status bit. A gas under test passes through the molecular sieve to remove non-methane total hydrocarbons such that the treated gas functions as a background gas for filling the first stored gas pipe and the second stored gas pipe. The six-pass valve and the multi-pass valve are configured to have an entered sample status bit such that zero-grade compressed air drives the gas inside the second stored gas pipe, quantification ring, and first stored gas pipe to enter the detector. The background gas inside the second stored gas pipe and the second stored gas pipe provides a baseline.Type: ApplicationFiled: January 29, 2016Publication date: December 15, 2016Inventors: CHING-CHIH LAI, HAO FANG, YAN XIONG
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Publication number: 20160363574Abstract: A method for determining an optimal radio frequency to break an emulsion comprises: analyzing an oil and water interface of an emulsion; defining the oil and water interface at a molecular level; simulating oscillation of molecules at the oil and water interface under different radio frequencies; and determining an optimal radio frequency to break the emulsion.Type: ApplicationFiled: June 10, 2016Publication date: December 15, 2016Inventors: Jeff Michael Sheremata, Peter Nelson Slater
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Publication number: 20160363575Abstract: This invention encompasses embodiments for multi-modal integrated simultaneous measurement of various aspects of fluids contained in circulating systems such as automotive reciprocating engines and vehicle transmissions. These circulating systems perform constant internal lubrication, and heat and contaminant removal to protect the internal moving parts from the inherent friction and damage in normal operation. Most commonly this is achieved with fluids based on hydrocarbon and/or related synthetics, which, over time, can lose their protective properties, and vary in their performance or breakdown/decay due to internal and external events. Several components within the lubricant fluid can be measured and can provide insight into the efficacy of the system to perform its designed mission. The mass and level of the fluid may also be monitored on an on-going basis. Described herein is a real-time, simultaneous, integrated, multi-modal sensor system for early warning notification.Type: ApplicationFiled: June 10, 2016Publication date: December 15, 2016Applicant: Micromem Applied Sensor Technologies Inc.Inventors: BRIAN VON HERZEN, STEVEN VAN FLEET, HAMISH FALLSIDE, RANDALL HALL
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Publication number: 20160363576Abstract: A multi-functional precious stone testing apparatus includes a portable housing, a testing unit, and an indication unit. The portable housing includes a hand-held casing and a probe casing extended from a front end of the hand-held casing. The testing unit includes a conductive probe having a testing end portion extended out of a tip end of the probe casing for contacting a testing object to determine a conductivity of the testing object. The indication unit includes a LED light unit received in the hand-held casing for illuminating the testing end portion of the conductive probe during testing, wherein the LED light unit is positioned away from the tip end of the probe casing for preventing heat generated from the LED light unit being transmitted toward the conductive probe to affect an accurate measurement for the conductivity of the testing object.Type: ApplicationFiled: August 18, 2016Publication date: December 15, 2016Inventors: Xiuling ZHU, Gary Bruce PECKHAM
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Publication number: 20160363577Abstract: A system configured to determine a property of a paving-related material is provided. The system includes a measuring device configured for measuring a property of a paving-related material and a cellular computer device configured for being in communication with and receiving data from the measuring device.Type: ApplicationFiled: October 8, 2013Publication date: December 15, 2016Applicant: Troxler Electronic Laboratories, Inc.Inventor: Robert Ernest Troxler
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Publication number: 20160363578Abstract: An apparatus for determining preferably Biologically Relevant Measurement Variables at membranes has at least one first plate-like or film-like substrate, which is made from at least one first material and has continuous openings or pores or can be perforated, and also has a second plate-like or film-like substrate which is made from at least one second material, to which measuring elements are assigned or on which measuring elements are situated. Cells or similar structures may be at least temporarily applied or permanently cultivated on the first substrate. According to the invention, the first substrate and the second substrate are assigned to one another at least during the measuring operation for determining the corresponding measurement variables, specifically preferably on flat sides which are opposite one another. In particular, this assignment is a connection of the two substrates, preferably a joining-together.Type: ApplicationFiled: February 18, 2015Publication date: December 15, 2016Inventors: Thomas Knott, Michael Huber, Peter Van Stiphout
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Publication number: 20160363579Abstract: Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating pathogens in blood containing blood cells are disclosed. The devices include a flow chamber having a solvent inlet, at least one host-fluid inlet, a particulate outlet, at least one residual outlet, and a reflector. The methods include trapping the pathogens in the acoustic standing wave, introducing a solvent into the flow chamber, and removing the pathogens from the device. Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating specialized circulating cells in blood containing blood cells are also disclosed. The devices include a flow chamber having at least one inlet and at least one outlet, and a microscope objective and a cover glass. The methods include driving the transducer to create an acoustic standing wave in the flow chamber and microbubbles in the blood.Type: ApplicationFiled: June 11, 2016Publication date: December 15, 2016Inventors: Rudolf Gilmanshin, Bart Lipkens
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Publication number: 20160363580Abstract: Provided herein are methods of metabolic kinetic phenotyping based on amino acids, proteins and other metabolites thereof. In the method a solution comprising a plurality of stable isotopes of amino acids is administered to the individual and one or more kinetic parameters of amino acids and the metabolites are calculated in blood samples taken periodically from the individual. The metabolic phenotype is composed from the kinetic parameters. Also provided are methods and kits for identifying a disease, such as chronic heart failure, in a patient using the metabolic parameters.Type: ApplicationFiled: June 13, 2016Publication date: December 15, 2016Applicant: The Texas A&M University SystemInventors: Nicolaas E. Deutz, Marielle P. Engelen
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Publication number: 20160363581Abstract: The present invention provides a method for identifying biomarkers and generating an output indicative of lung cancer. The method for identifying biomarkers comprises the steps of collecting a breath sample from subjects known to have lung cancer and subjects known to be free of lung cancer; analyzing the collected breath samples to determine all mass ions in each of the collected breath samples using at least one time-resolved separation technique and at least one mass-resolved separation technique; identifying a subset of the determined mass ions in a processor as the biomarkers for detecting lung cancer, the subset of the determined mass ions are statistically significant for detecting lung cancer; and combining the subset of the determined mass ions in a multivariate algorithm in the processor to generate a value of a discriminant function indicating the likelihood that the subject has lung cancer.Type: ApplicationFiled: June 9, 2016Publication date: December 15, 2016Inventor: Michael PHILLIPS
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Publication number: 20160363582Abstract: A method is disclosed comprising receiving air exhaled by a user into a breath analysis apparatus, exposing the received air to a sensor, collecting data from the sensor regarding one or more constituents in the received air, analyzing the data to determine an analysis result, determining one or more vaporizable materials to vaporize based on the analysis result, and dispensing a vapor from the breath analysis apparatus by vaporizing the one or more vaporizable materials.Type: ApplicationFiled: June 13, 2016Publication date: December 15, 2016Inventor: Jonathan Seamus Blackley
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Publication number: 20160363583Abstract: A method for screening an anticancer candidate is disclosed. The method includes immobilizing gold nanoparticles onto a substrate; binding a protein involved in carcinogenesis and metastasis to the immobilized gold nanoparticles, recording a spectrum of the protein conjugate, and analyzing the spectrum to obtain reference data; adding a candidate inhibiting the activity of the protein to the protein conjugate, recording a spectrum of the mixture, and analyzing the spectrum to obtain comparative data; and comparing the reference data with the comparative data to determine whether the candidate inhibits the activity of the protein. The method enables screening of a candidate inhibiting the activity of a protein involved in carcinogenesis and metastasis in an accurate and convenient manner.Type: ApplicationFiled: April 28, 2016Publication date: December 15, 2016Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventors: Sang Jun SIM, So Jin SONG
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Publication number: 20160363584Abstract: The present disclosure provides compositions, systems, and tools for modeling liver inflammation and methods of using the same. The disclosure provides micropatterned hepatocyte-Kupffer cell co-cultures or Kupffer cell-treated hepatocyte co-cultures where hepatocytes maintain Kupffer cell-initiated activities during long-term culture. The in vitro liver inflammation models of the present disclosure may be useful for evaluating both acute as well as chronic inflammation-mediated toxicities of compounds in a pre-clinical setting.Type: ApplicationFiled: January 8, 2016Publication date: December 15, 2016Inventors: John K. McGeehan, Okechukwu Ukairo, Onyi Irrechukwu, Michael McVay
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Publication number: 20160363585Abstract: Disclosed herein is a first responder hazardous material detection and isolation distance (HMDID) apparatus and method that addresses the disconnect that exists in two current first responder tools: a means for detecting a hazardous material, but also the need for an immediate action plan to secure a dangerous area and prevent harm to individuals, such as first responders present at an emergency scene. The detection apparatus comprises test membranes configured to detect a hazardous material present in the atmosphere, by producing a visual color change when exposed to air contaminated with the hazard. The test membranes are attached to a planar form, such as a flat paper card, and are accompanied by an isolation indicator and action item for isolating an area depending on the level of hazardous material present in the atmosphere.Type: ApplicationFiled: April 14, 2014Publication date: December 15, 2016Inventors: Chad Matthew McClintock, John R. Zour
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Publication number: 20160363586Abstract: The present invention relates to a method for detecting a target substance that is useful for detection of a glycoprotein and the like comprising a specific sugar chain, a reagent for detecting a target substance, a carrier and a method for manufacturing the carrier.Type: ApplicationFiled: August 24, 2016Publication date: December 15, 2016Applicant: SYSMEX CORPORATIONInventors: Chikayuki TSURUNO, Shinya NAGAI, Minako TERAO, Chika MIZUTA, Takuya KYOUTOU
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Publication number: 20160363587Abstract: A composition comprising one or more antibodies covalently attached to a magnetic nanoparticle via a linker. The magnetic nanoparticle comprises a magnetic core and a non-magnetic outer surface layer. The one or more antibodies are specific for one or more target cells or one or more target biomolecules in a biological sample. The linker comprises ethylene glycol and/or thiol. The invention also provides methods for fabricating such antibody conjugated nanoparticles and procedures for their applications in selective separation/isolation of target cells or target biomolecules from biological matters.Type: ApplicationFiled: May 9, 2016Publication date: December 15, 2016Inventors: Raghuraman Kannan, Shreya Ghoshdastidar, Dhananjay Suresh, Danny Schust, Anandhi Upendran
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Publication number: 20160363588Abstract: The present invention relates to a method for analyzing urine sample and a reagent kit for analysis of urine sample, which are for detecting at least sperms and yeast-like fungi as urinary particles.Type: ApplicationFiled: February 27, 2015Publication date: December 15, 2016Applicant: SYSMEX CORPORATIONInventor: Masanori KAWANO
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Publication number: 20160363589Abstract: A method for determining, in vitro, the probability of a patient developing severe dengue, based on a blood sample, in which: a) the quantity in the blood sample of at least one marker, which is platelet factor 4, is determined; b) the quantity of platelet factor 4 determined in step a) is compared with a reference quantity of the marker obtained from a group of individuals who have been diagnosed with non-severe dengue, wherein, if the quantity of platelet factor 4 determined in step a) is less than the reference quantity established in step b), it is determined that the patient will develop severe dengue.Type: ApplicationFiled: February 12, 2015Publication date: December 15, 2016Applicant: BIOMERIEUXInventors: Frederic Bedin, Romain Fragnoud