Abstract: A method for determining, in vitro, the probability of a patient developing severe dengue, based on a blood sample, according to a) the quantity in the blood sample of at least one marker, which is olfactomedin 4, is determined, b) the quantity of olfactomedin 4 determined in step a) is compared with a reference quantity of the marker obtained from a group of individuals who have been diagnosed with non-severe dengue, wherein, if the quantity of olfactomedin 4 determined in step a) is greater than the reference quantity established in step b), it is determined that the patient will develop severe dengue.

Abstract: 13 antagonist, (iv) to prognosticate the outcome of treating an IL-13 mediated condition or disorder with a specific IL-13 antagonist. The disclosure further provides assay kits for the detection of DPP4, as well as computer implemented diagnostic methods.

Abstract: A diagnostic method for determining prognosis of a myocardial infarcted patient, wherein the amounts of FXIII protein are determined on the day of myocardial infarction (t0) and at least on the following three days (t1 to t3), wherein a lowering of FXIII amount on any one of t0 to t3 below a threshold value is indicative of an increased risk of poor prognosis.

Abstract: This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.

Abstract: The present invention describes methods of prognosticating patient survival based on an analysis of the ZEB1 gene or gene product. The present invention also describes methods of selecting and/or selecting various therapies based on the analysis of ZEB1, IDH1, PTEN, MGMT and/or RET. Further describes are systems for analyzing ZEB1, IDH1, PTEN, MGMT and/or RET as well as selecting and/or selecting the therapies.

Abstract: Disclosed is a therapeutic method including administering a TIM-3 antibody or its TIM-3 binding fragment to a subject who is suspected to be suffering from blood tumor and in whom TIM-3 has been expressed in a Lin(?)CD34(+)CD38(?) cell fraction of bone marrow or peripheral blood or a subject who has been received any treatment for blood tumor. Conceived diseases include those diseases which can be treated through the binding or targeting of the TIM-3 antibody or its TIM-3 binding fragment to blood tumor cells (AML cells, CML cells, MDS cells, ALL cells, CLL cells, multiple myeloma cells, etc.), helper T cell (e.g., Th1 cells, Th17 cells), and antigen-presenting cells (e.g., dendritic cells, monocytes, macrophages, and cells resembling to the aforementioned cells (hepatic stellate cells, osteoclasts, microglial cells, intraepidermal macrophages, dust cells (alveolar macrophages), etc)).

Abstract: The present invention provides a set of DETERMINANTS (e.g., genes and gene products) that can accurately inform about the risk of cancer progression and recurrence, as well as methods of their use.

Abstract: The present invention describes the generation of an anti-idiotype single-chain Fv (scFv) antibody specific for the murine (RFB4), chimeric (SM03) and humanized (SM06) versions of an anti-CD22 antibody (“the anti-CD22 antibodies”). The present invention further describes the construction of a murine IgG2a/kappa immunoglobulin carrying the variable region sequences of the anti-idiotype scFv sequences. Additionally, the present invention provides a cell line capable of producing an anti-idiotype murine antibody specific for “the anti-CD22 antibodies.” The present invention is directed against a method for identifying and evaluating the activities and concentration of “the anti-CD22 antibodies.” Additionally, the present invention provides a method for evaluating serum concentration of “the anti-CD22 antibodies” that are being used clinically. The present invention is also directed against a method to detect HAMA, HACA and HAHA responses in patients treated with “the anti-CD22 antibodies.

Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.

Abstract: The present invention relates to biomarkers and diagnostic and prognostic methods for Alzheimer's disease and other neurodegenerative disorders. The invention also provides compositions for detecting the biomarker as well as compositions and methods useful for treating Alzheimer's disease and other neurodegenerative disorders.

Abstract: The present technology relates generally to fluidics devices for measuring platelet coagulation and associated systems and methods. In some embodiments, a fluidics device includes an array of microstructures including pairs of generally rigid blocks and generally flexible posts. The fluidics device further includes at least one fluid channel configured to accept the array. The fluidics device can further include a measuring element configured to measure a degree of deflection of one or more of the flexible posts in the array. In some embodiments, the fluidics device comprises a handheld device and usable for point of care testing of platelet forces and coagulation.

Abstract: The present invention inter alia provides a method, and use thereof, of diagnosing and/or predicting atherosclerosis or CVD by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in detecting and predicting atherosclerosis and CVD than currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating atherosclerosis or CVD. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of atherosclerosis or CVD.

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided are antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

Abstract: A replaceable cartridge for a biological analyte measurement device includes housing configured for removable engagement therefrom, and a support medium disposed within the housing. The support medium carries test pads made of a thin layer of fluid transporting material, and hermetic isolation pads made of a fluid impermeable material. The housing provides a port through which test pads are exposable to an external environment; and a set of sealing elements that define a cross sectional area within a channel internal to the housing, through which the support medium, test pads, and hermetic isolation pads are displaceable. Engagement of a hermetic isolation with the set of sealing elements results in the formation of a hermetic seal within the housing. Hermetic isolation pads can be formed as portions of cleanse pads that can be wiped across surfaces corresponding to a set of sensors, or as sealing pads separate from cleanse pads.

Abstract: An automated analyzer maintains high processing capacity and dispensation accuracy even when items requiring dilution/pretreatment and general reaction measurement are mixed. A plurality of sample dispensing mechanisms are independently driven and each include a sample collection position, a sample nozzle for collecting the sample, and a washing tank for washing the sample nozzle. The sample dispensing mechanisms are configured to collect the sample from a plurality of sample collection positions and are operated independently to perform sample dispensation into reaction containers on a reaction disc. At least one of the sample dispensing mechanisms is provided for each of a sample requiring dilution/pretreatment and a sample that does not require dilution/pretreatment. The automated analyzer is provided with a control means for causing the respective mechanisms to be operated in a dedicated manner. The sample is dispensed such that no vacancy is created in the reaction containers.

Abstract: Methods and systems for transportable self-operating lab system units are disclosed. In certain implementations, the lab system may be contained within a shipping container configured to be modular or otherwise cooperate with each other or another system. The units may be configured to be readily transportable and configured to be set up in various locations. Additionally, a unit may be configured to utilize robotic systems to enable the unit to receive and analyze specimens without the need for support personnel to be present. The unit may be configured to be managed remotely and request local assistance as needed. The system may be configured to obviate the need for highly-trained personnel, expensive equipment, costly maintenance and instruments running near capacity to offset cost, thereby making the most advanced analytical methodologies available to small, non-research communities.

Abstract: A method of operating an apparatus for detecting and recording accelerations experienced by a structure is provided, the apparatus comprising an accelerometer, a processor and a non-volatile computer memory device. The method comprises the steps of: i. operating the processor, accelerometer and computer memory device in a reduced power state; ii. in response to detecting an acceleration having a magnitude which is greater than a first preselected threshold magnitude, switching the accelerometer to a fully operational state and storing accelerometer data in a buffer; iii. switching the processor and computer memory device to a fully operational state; iv. operating the processor to store the accelerometer data from the buffer in the computer memory device; v. switching the processor and computer memory device to a reduced power state until the accelerometer signals that further data is available, and storing any further accelerometer data in the buffer; vi.

Abstract: An analysis system includes a storage module for storing a track indicating in time series a position of an individual that is moving as track data and for storing sensor data indicating in time series a measurement result of the individual by a sensor worn by the individual, a speed calculation module for calculating a speed index indicating a movement speed of the individual based on the track data, an index calculation module for calculating a behavior index indicating a movement intensity of the individual based on the sensor data, a similarity degree calculation module for calculating a degree of similarity between the speed index and the behavior index based on changes in time series of the speed index and the behavior index, and an association module for associating the track and the individual on which the sensor data has been measured based on the degree of similarity.

Abstract: A measuring device having at least one at least approximately tubular probe device, by means of which an impact pressure, a total pressure or a dynamic pressure of a flow can be determined, and which is designed movable at least between a first operating state and a second operating state, where the probe device can be moved by an actuating unit in a controlled manner between the first operating state and the second operating state and held in said states.

Abstract: A method of forming a capacitive micro-electro-mechanical system (MEMS) sensor device includes at least one capacitive MEMS sensor element with at least one capacitive MEMS sensor cell. A patterned dielectric layer including a thick dielectric region and a thin dielectric region is formed on a top side of a first substrate. A second substrate is bonded to the thick dielectric region to provide at least one sealed micro-electro-mechanical system (MEMS) cavity. The second substrate is thinned to reduce a thickness of said second substrate to provide a membrane layer. Vias are etched through the membrane layer and said thick dielectric region extending into the first substrate to form embedded vias. A dielectric liner which lines the embedded vias is formed within the first substrate. The embedded vias are filed with electrically conductive TSV filler material to form a plurality of through-substrate vias (TSVs), said plurality of TSVs extending to at least a top of said membrane layer.

Abstract: Disclosed are an electrical contact for contacting an electrical component, an apparatus for testing an electrical component and a method of assembling an apparatus comprising an electrical contact for testing an electrical component.

Abstract: A module plate is provided for use with a wafer handler and testing mechanism. The module plate has a diameter equivalent to an integrated circuit wafer and a height equivalent to or less than a height of a module lid associated with each module in a plurality of modules associated with the module plate. The module plate has a plurality of cutouts in the module plate that have a width equivalent to a width of the module lid and at least a length equivalent to a length of the module lid. The height of the module plate is such that, when a test head contacts a module base of each module in a plurality of modules, the module lid contacts a chuck on which the module plate resides during testing of the module thereby providing resistance in order to accurately test the module.

Abstract: According to one embodiment, an inspection device of a display device, includes a first probe block which includes first probes, a probe block attachment which supports the first probe block to enable a position of the first probe block to be set variably, a signal source which supplies a signal to the first probes, and a transmission cable which connects the first probe block with the signal source.

Abstract: Etching for probe wire tip is described particularly well suited to microelectronic device test. In one example, wires of a probe head are covered with an encapsulation material, the wires being attached to a test probe head substrate, each of the wires having two ends, the first end being attached to the substrate and the second end being opposite the substrate, each wire having an outer coating around a core. The wires are etched to remove the outer coating at the second end of the wires. The encapsulation material is then removed.

Abstract: A frequency synthesizer 11a outputs a periodic signal r(t) at a frequency detuned by a predetermined frequency ?f [Hz] from a frequency of 1/integer of a frequency of a reference clock signal f0 synchronized with a signal to be measured ws. A first sampler unit 12 samples the signal to be measured ws at a timing of the trigger signal CLK. A second sampler unit 13a samples an I signal I(t) at the timing of the trigger signal CLK. A phase shifter 13b outputs a Q signal Q(t) obtained by shifting a phase of the reference clock signal f0 by 90°. A third sampler unit 13c samples the Q signal at the timing of the trigger signal CLK. A correction value calculation unit 13d calculates a correction value ?t(n) based on sampling data I(n) and Q(n) and a set value t(n) of a sampling time.

Abstract: A method for measuring a load current flowing through a switch is proposed, in which a defined offset current is applied to a measurement current, in which the defined offset current is determined during at least two intervals of time during which the switch is switched on, in which the load current is determined on the basis of the defined offset current using the measurement current. A corresponding circuit is also stated.

Abstract: An apparatus for efficient, precise and accurate measurement of the frequency, amplitude, and phase of a single input tone frequency and/or multiple separable input tone frequencies. Tone separability can be achieved by proper selection of the parameter N, the sample length of the DFT/FFT. Application of the invention includes but is not limited to test and measurement, tone interference removal, and communications systems, where precise and accurate measurement of tonal parameters is needed.

Abstract: A method is presented for measuring the electric field of electromagnetic radiation using the spectroscopic responses of Rydberg atoms to the electromagnetic radiation field. The method entails implementing quantitative models of the Rydberg atom response to the electromagnetic radiation field to provide predetermined atomic properties or spectra for field amplitudes and or frequencies of interest, spectroscopically measuring the response (spectrum) of Rydberg atoms exposed to an unknown electromagnetic radiation field, and obtaining the electric field amplitude and/or frequency of the unknown electromagnetic radiation by using features extracted from the measured spectrum and comparing them to features in a predetermined spectrum among the set of predetermined spectra.

Abstract: The separated particle charge multivariate analysis instrument includes a transparent sealed container and, inside the transparent sealed container, an axial fan, a tube carrier plate, a rail board, double screw shafts, a biaxial motor, parallel electrode plates and so on. The separated particle charge multivariate analysis instrument of the present invention measures out the charge amount of the particle after leaving the particle bed by simulating a controllable environmental factor in the transparent sealed container on the basis of the inner tube, the outer tube, the electrometer and the charge amount of the particle entering into the inner tube at the measurement site, and analyzes effects of environmental factors, particle physical parameters and geometric parameters to the charge by adjusting environmental variables in the transparent sealed container.

Abstract: An apparatus for jitter measurement includes a first delay circuit, a second delay circuit, and a control circuit. The first delay circuit imposes a preliminary phase delay on an input signal to generate a delayed input signal. The second delay circuit operates with the first delay circuit to impose a fine phase delay on the delayed input signal. The control circuit controls amounts of delays imposed by the first and second delay circuits, and fine tunes the phase delay of the delayed input signal according to the amounts of delays respectively imposed by delay elements of the first and second delay circuits, and estimates or calculates a jitter window for the input signal according to adjustment results of the first and second delay circuits.

Abstract: A ground fault detection circuit is configured to detect a ground fault in a circuit or system that has more than one ground reference. In an embodiment, an electronic circuit includes a first circuit coupled to a first ground node. The first ground node is coupled to a first ground reference. The electronic circuit also includes a second circuit coupled to a second ground node. The second ground node is coupled to a second ground reference. The ground fault detection circuit is configured to detect an open circuit between the first ground node and the first ground reference or between the second ground node and the second ground reference by comparing a voltage at the first ground node to a voltage at the second ground reference or comparing a voltage at the second ground node to a voltage at the first ground reference.

Abstract: The present invention is directed towards a mobile apparatus mounted to a motor vehicle for detecting energized objects.

Abstract: The enhanced dynamic range RF pulse measurement system accepts an RF source for spectral analysis. The system includes an RF splitter accepting the RF source under analysis as input. The split output connects to identical precision timing insertion units (TIU) 1 and 2, each time tagging its respective RF signal stream. TIU 1 feeds a first real-time spectrum analyzer (RSA 1) set for strong signals at an exemplary ?3.00 dBm reference level. TIU 2 feeds a second real-time spectrum analyzer (RSA 2) set for weak signals at an exemplary ?15.00 dBm reference level. Outputs of RSA 1 and RSA 2 are then fed to a multi-channel recorder which records the respective time tagged RF signal streams. For each signal stream real-time PDW processing is performed. Output of the recorder feeds a workstation that for any given time tag selects and processes the channel having the highest quality signal.

Abstract: An apparatus is disclosed. The apparatus includes a circuit, a conductor interconnecting a portion of the circuit, and a processor configured to determine a temperature of the conductor and adjust at least one parameter related to the conductor in response to the determined temperature rising above a threshold. The at least one parameter includes a lifetime estimate for the conductor. A method of operating an apparatus including a circuit and a conductor interconnecting a portion of the circuit is disclosed. The method includes determining a temperature of the conductor, and adjusting at least one parameter related to the conductor in response to the determined temperature rising above a threshold. The parameter includes a lifetime estimate for the conductor.

Abstract: A chassis platform, such as processor or a system-on-chip (SoC), includes logic to implement a debug chassis security system including a policy generator to control access from a test access port. The policy generator may distribute a debug policy to at least one logic block that locally enforces the debug policy. The debug policy may include a delayed authentication policy in which debug assets are distributed and the chassis platform is initially locked to prevent debug access via the test access port. An authenticated debug user may unlock the chassis platform at a later time to enable debugging operations. The debug policy may also include a live execution policy and an immediate debug policy.

Abstract: A computer program product is provided for performing symbol timing recovery in a parallel recording channel system. The computer program product comprises a computer readable storage medium having program instructions embodied therewith. The program instructions are executable by a processor to cause the processor to receive a plurality of timing-error estimates for a plurality of read channels. Each of the timing-error estimates corresponds to one of the read channels. Also, the program instructions are executable by the processor to cause the processor to calculate a common phase based on the plurality of timing-error estimates. Moreover, the program instructions are executable by the processor to cause the processor to calculate a skew of a transducer array based on the plurality of timing-error estimates, and to calculate a different total phase estimate for each read channel based on the calculated common phase and the calculated skew of the transducer array.

Abstract: Integrated circuit packages with multiple integrated circuit dies are provided. A multichip package may include a master die that is coupled to one or more slave dies via inter-die package interconnects. A mixed (i.e., active and passive) interconnect redundancy scheme may be implemented to help repair potentially faulty interconnects to improve assembly yield. Interconnects that carry normal user signals may be repaired using an active redundancy scheme by selectively switching into use a spare driver block when necessary. On the other hand, interconnects that carry power-on-reset signals, initialization signals, and other critical control signals for synchronizing the operation between the master and slave dies may be supported using a passive redundancy scheme by using two or more duplicate wires for each critical signal.

Abstract: A ground fault circuit interrupter (GFCI) including separable contacts, a ground fault detection circuit structured to detect a ground fault based and to output a trip signal in response to detecting the ground fault, a trip circuit structured to trip open the separable contacts in response to the trip signal, a test button structured to be actuated by a user, a test unit structured to sequentially perform a GFCI self-test sequence and a ground fault test sequence in response to actuation of the test button, wherein the test unit is structured to determine whether the GFCI passed the GFCI self-test sequence and to output in an alarm signal in response to determining that the GFCI failed the GFCI self-test sequence, and an indicator structured to receive the alarm signal and to provide a visual or audible indication in response to receiving the alarm signal.

Abstract: A system for management of a circuit breaker counter according to an exemplary embodiment of the present invention includes a data processing unit receiving state change data and measurement data of at least one of a circuit breaker and a current measuring unit and transferring an event on the basis of the state change data and measurement data; and a counter managing unit counting a total operation, a load-breaking operation and a fault-breaking operation of the circuit breaker, based on the event and the measurement data, and outputting and storing respective count accumulation values.

Abstract: System and methods for estimating a future power capability of a battery system included in a vehicle are presented. In some embodiments, a method for estimating a future power capability of a battery system may include determining an initial battery voltage when the battery operates at a current limit and estimating a future battery current at a first time when the battery operates at the associated voltage limit based on the initial battery current. A future battery voltage at the first time when the battery operates at the associated current limit may be determined based on the initial battery voltage. An estimated voltage-limited power capability of the battery at the first time may be determined based on the future battery current and an estimated current-limited power capability of the battery at the first time may be determined based on the future battery voltage.

Abstract: System and methods for estimating a relationship between a SOC and an OCV of a battery system included in a vehicle are presented. In certain embodiments, an initial relationship between an open circuit voltage (“OCV”) and a state of charge (“SOC”) of a cell of the battery system may be determined at a beginning of life of the cell. Changes in one or more stoichiometric points of a half-cell of the cell may be determined as the cell ages. Based on the determined stoichiometric point changes of the half-cell, an initial relationship between the OCV and the SOC of the cell may be adjusted to generate an updated relationship between the OCV and the SOC of the cell.

Abstract: System and methods for estimating a capacity of a battery system and/or a constituent cell and/or pack included in a vehicle are presented. In certain embodiments, a method for estimating a capacity of a battery system may include determining voltage-based state of charge (“SOC”) data of a pack of the battery system based on measured pack voltage information and a relationship between an open circuit voltage (“OCV”) and the SOC of the pack of at a beginning of life of the pack. Beginning of life SOC data of the pack may be determined based on coulomb counting measurements, and a ratio may be determined based on the beginning of life SOC data of the pack and the voltage-based SOC data of the pack. An estimated present capacity of the pack may be determined based on the beginning of life capacity of the pack and the ratio.

Abstract: An apparatus for estimating a state of a battery including a data receiver configured to receive module data associated with a battery module included in a battery pack from the battery module, and a processor configured to acquire cell data corresponding to a battery cell included in the battery module from the module data, and determine a module state of the battery module based on the cell data.

Abstract: A state-detection device, adapted in a host, includes a battery, a gas gauge, a processor, and a display. The battery is operating in an operation state. The gas gauge is configured to instantly detect the operation state and stores state information of the battery in a plurality of registers. The processor determines, according to the state information, whether the battery is operating in a normal state, a temporary failure state, or a permanent failure state to generate state-determination information. When the battery is operating in the temporary failure state, the processor further determines whether the temporary failure state is an over-temperature state, an over-voltage state, or an over-current state according to a first value, a second value, and a third value, respectively, of the state information. The display is configured to display the state-determination information.

Abstract: A battery tester for efficiently extracting intrinsic characteristics of a battery. The battery tester comprises a sensing unit, a controller, bi-directional power converter, and an energy storage unit so that energy discharged from a battery during testing is stored in the energy storage unit and recycled back to the battery. The battery tester uses a high current pulse test and a switching excitation test with a modified particle arm optimization algorithm to analyze precise model parameters that can be used to describe the health conditions of a battery.

Abstract: A method of forming a sensor array comprising a series connection of parallel GMR sensor stripes that provides a sensitive mechanism for detecting the presence of magnetized particles bonded to biological molecules that are affixed to a substrate. The adverse effect of hysteresis on the maintenance of a stable bias point for the magnetic moment of the sensor free layer is eliminated by a combination of biasing the sensor along its longitudinal direction rather than the usual transverse direction and by using the overcoat stress and magnetostriction of magnetic layers to create a compensatory transverse magnetic anisotropy. By making the spaces between the stripes narrower than the dimension of the magnetized particle and by making the width of the stripes equal to the dimension of the particle, the sensitivity of the sensor array is enhanced.

Abstract: A sensor apparatus having at least one magnet core, on at least one carrier surface, which encompasses at least one soft magnetic material and for which a respective longitudinal center plane, which is oriented perpendicularly to the carrier surface and divides the respective magnet core into two halves having an identical mass, is definable, at least one coil being on, around, and/or adjacent to the at least one magnet core, the at least one magnet core having in its interior sub-regions by which an initiation of a magnetization reversal of the respective magnet core is targetedly locally controllable since a drive energy to be applied for propagation of a magnetic domain wall is elevated. Also described is a manufacturing method for a sensor apparatus having at least one magnet core, and a method for ascertaining a field strength of a magnetic field in at least one spatial direction.

Abstract: A magnetic field measuring device having a first semiconductor body having a surface formed in a first x-y plane, the first semiconductor body having on the surface two magnetic field sensors which are spaced apart and arranged along a first connecting line, and wherein the magnetic field sensors respectively measure a z-component of a magnetic field, and the x-direction and the y-direction and the z-direction are each formed orthogonally to each other. A first magnet is provided with a planar main extension surface formed in a second x-y plane and with a symmetry surface formed in an x-z plane, wherein the direction of magnetization extends substantially or exactly parallel to the main extension surface and substantially or exactly parallel to the plane of symmetry. The first semiconductor body and the first magnet are rigidly fixed to each other.

Abstract: A magnetic field sensor includes a phase-locked loop to receive a measured magnetic field signal formed from sensing element output signals of a plurality of magnetic field sensing elements in response to a magnetic field. The phase-locked loop is configured to generate an angle signal having a value indicative of the angle of the magnetic field. Associated methods are also described.

Abstract: A selectively removable closure for closing the open end of an NMR sample tube having an open end and a closed end of the invention includes a cylindrical proximal first and a distal second portion, both portions substantially congruent to a central axis, the second portion has a hollow bore extending therethrough, the hollow bore has: a first and a second distal section, a central section and a proximal section. The first distal section has an inside diameter sized to accept the outside diameter of a preselected size NMR sample tube substantially without an interference, the second distal section has an interference that ends into the central section with a ramp with an angle to the central axis greater than 70 degrees, the central section corresponds in a locked position on the NMR sample tube with a locking ring at least partially surrounding the NMR locking tube to form a secondary locking seal.