Abstract: A web material containing one or more active agents and methods for making same are provided.

Abstract: The present invention relates to a cosmetic composition comprising core particles in a cosmetically or pharmaceutically acceptable carrier, wherein the core particles comprise a heat-curable coating which is the reaction product of a vinyl-functional silicone polymer, a hydride-functional crosslinker, and a metal catalyst.

Abstract: A stable cosmetic agent in the form of a plurality of encapsulated particles in a core-shell configuration. The encapsulated particles are formed by coating nicotinamide riboside powder or a nicotinamide riboside containing material with one or more water-insoluble encapsulating agents. The stable encapsulated nicotinamide riboside particles exhibit less than 20% hydrolysis when incorporated into an aqueous skin care composition.

Abstract: A method of treating biofilm disease using a pH adjusted therapeutic rinse that comprises two parts that are separated and in amounts that upon mixing provide a single dose. The two parts together and then rinsing a patient's mouth with the single dose and expectorating.

Abstract: The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high total amounts of UV filtering agents. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.

Abstract: Provided are a plant extract composition and a pharmaceutical composition for inhibiting tyrosinase activity, preventing melanogenesis or treating melanogenesis, wherein the plant extract composition contains curcumin and resveratrol by weight ratio from 4:1 to 1:4. The plant extract composition and the pharmaceutical composition are useful for preventing and treating pigmentation for skin whitening, and achieve the effect of whitening skin and reducing pigmentation for a subject in topical site.

Abstract: A topically applicable chemical peel composition having from about 5% to about 25%, by weight, of alpha hydroxy acid, from about 11% to about 22%, by weight, of salicylic acid, from about 4% to about 13%, by weight, of phenylethyl resorcinol and balance essentially dermatologically acceptable liquid solvent. In addition, a chemical skin peel regime or regimen including topical application onto the skin is also disclosed.

Abstract: The present invention relates to a para-aminophenol compound of formula (I), the addition salts thereof with an acid and the solvates thereof: in which: R represents a hydrogen or halogen atom; a C1-C4 alkyl radical; a carboxyl radical or a (C1-C4)alkoxycarbonyl radical; Z1 is an oxygen atom or a group NR2; R2 is a hydrogen atom or a linear or branched C1-C4 alkyl radical, a benzyl radical or an acetyl radical; R1 is a saturated, linear or branched C1-C10 alkyl radical, which is substituted with or interrupted by a cationic radical, optionally interrupted by one or more oxygen atoms and/or by one or more groups NR2, optionally substituted with one or more radicals chosen from hydroxyl, alkoxy or C1-C4 hydroxyalkyl radicals; or R1 is a saturated, unsaturated or aromatic cationic 5- to 8-membered heterocycle optionally substituted with one or more radicals chosen from C1-C4 alkyl, hydroxyl, C1-C4 alkoxy, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, thio, (C1-C4)alkylthio, carboxyl, (C1-C4)alkylcarbo

Abstract: The present invention discloses a stable biocidal composition with enhanced anti-fungal activity at low concentration of active(s) and a process for preparing the same. The composition comprises: zinc pyrithione, C8-C18 quaternary ammonium salt (preferably cetylpyridinium chloride), water miscible glycol/polyol/glycol ether/lactam, organic amine and/or alkanol amine The composition can be formulated into: hair care formulations, antidandruff hair care formulations, water based paints, coatings, adhesives, hard surface cleaners, fabric care compositions, wood products, plastic products and medical products. The biocidal compositions and the resulting formulations are transparent or opaque and are stable at varying pH and humidity conditions.

Abstract: The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high total amounts of UV filtering agents. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.

Abstract: The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high total amounts of UV filtering agents. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.

Abstract: The invention relates to an oil-based skin protector for application to the human skin comprising at least one film former as well as the use thereof.

Abstract: A stable cosmetic agent that includes an encapsulated particle in a core-shell configuration. The encapsulated particle is formed by coating nicotinamide riboside powder or a nicotinamide riboside containing material with one or more encapsulating agents. The stable encapsulated nicotinamide riboside particles exhibit less than 20% hydrolysis when incorporated into an aqueous skin care composition.

Abstract: A skin care product is provided. The skin care product includes a multi-component skin care composition disposed in a multi-chamber container. The multi-component skin care composition includes an aqueous carrier component and a nicotinamide riboside component disposed in separate chambers, which prevents these components from contacting one another prior to use. The aqueous carrier component and the nicotinamide riboside component can be separated from one another by one or more fluid impermeable dividing members and/or activatable elements, which upon activation enable contact between the aqueous carrier component and nicotinamide riboside component.

Abstract: The present invention aims to provide a cyclosporine external preparation showing improved transdermal absorbability of cyclosporine. The present invention provides an external preparation containing cyclosporine and a ketone.

Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a non-cross linked functionalised lignin oligomer, wherein the lignin oligomer: (a) has a number average molecular weight (Mn) in the range of from 800 Da to 1,800 Da; (b) comprises the functional group: lignin_backbone-O—L—COOH wherein: lignin backbone' is the lignin structural backbone; and L is a linker comprising an —OH moiety; (c) has a hydroxyl content of at least 3 mmol/g; and (d) has a functionalisation content of from 0.2 mmol/g to 2.3 mmol/g.

Abstract: A consumer goods product comprising a consumer goods product ingredient and a cross-linked co-polymer of a lignin oligomer and a vinyl monomer, wherein the lignin oligomer has: (a) comprises less than 1 wt % sulphur content; (b) has a number average molecular weight (Mn) of from 800 Da to 1,800 Da; and (c) has an average number of lignin monomers of from 3 to 8.

Abstract: The present invention provides an external-use liquid skin-conditioning composition that not only reduces the sticky and friction sensations caused by the inclusion of tranexamic acid, but also has a rich body without feeling slimy and softens the skin after use. The composition comprises (A) 0.5 to 5 mass % of at least one item selected from a group consisting of tranexamic acid and derivatives thereof and (B) 0.005 to 1.5 mass % of carboxymethylcellulose, has a viscosity of no greater than 500 mPa s at 30° C., and is transparent or semitransparent with an L value between 50 and 100 inclusive. Preferably the composition contains only carboxymethylcellulose as a thickener.

Abstract: Disclosed is a method of preparing a hair conditioning composition, wherein the composition comprising: a mono-alkyl amine cationic surfactant; a high melting point fatty compound; an anionic polymer comprising higher % of a vinyl monomer (A) with a carboxyl group; a polyol; and an aqueous carrier, wherein the method comprises the steps: mixing the cationic surfactant, high melting point fatty compound, polyol and aqueous carrier to form an emulsion; and adding the anionic polymer to the emulsion before, during or after forming the emulsion. The method of the present invention provides hair conditioning compositions having reduced chunks while containing both mono-alkyl amine cationic surfactants and anionic polymers containing higher % of vinyl monomer with carboxyl group.

Abstract: Disclosed is a method of preparing a hair conditioning composition, wherein the composition comprising: a mono-alkyl amine cationic surfactant; a high melting point fatty compound; an anionic polymer comprising higher % of a vinyl monomer (A) with a carboxyl group; and an aqueous carrier, wherein the method comprises a step: mixing the cationic surfactant, high melting point fatty compound, anionic polymer and aqueous carrier to form an emulsion.

Abstract: A skin whitening composition comprising a liquid polymeric coating material that, upon exposure to ambient air and moisture in skin, hardens to a water resistant, water vapor permeable, adherent and conformable solid film when applied to skin, and at least one skin whitening active; and a method and kit for whitening skin.

Abstract: A method for forming a transfer-resistant cosmetic composition comprising the steps of dissolving a silicone acrylate polymer powder in a naturally derived volatile solvent to form a premix and a carrier wherein the silicone acrylate polymer powder and the volatile solvent are present at a ratio of from about 3:1 to about 1:1 in the premix.

Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a non-crosslinked functionalised lignin oligomer, wherein the functionalised lignin oligomer: (a) has an average number of lignin monomers of from 3 to 8; (b) comprises a polyethylene glycol functional group; (c) comprises a functionalisation content between 90 and 0.5% lignin (m/m), wherein the consumer goods product ingredient is an emulsifier, and wherein the lignin oligomer is in the form of an emulsion, and wherein the consumer goods product is in the form of an oral care composition or a detergent composition.

Abstract: The present invention relates to a make-up cosmetic composition containing MQ silicone resin and propyl silsesquioxane resin, and, more specifically, relates to a make-up cosmetic composition which contains MQ silicone resin and propyl silsesquioxane resin, gives an outstanding moisturising impression and is free from any pulling phenomenon.

Abstract: The present invention relates to a transfer-resistant cosmetic composition comprising at least one silicone film forming polymer derived from acrylic acid, at least one volatile solvent and a cosmetically acceptable carrier.

Abstract: The present invention relates to a method for forming coated particles, comprising the steps of: agitating a volume of core particles while heating to a constant average temperature of about 40° C. Once particles are generally evenly mixed, with no apparent agglomeration, the vinyl-functional silicone polymer, hydride-functional crosslinker, and metal catalyst are combined in a premix under continuous propeller-mixing. The vinyl-functional silicone polymer, hydride-functional crosslinker, and metal catalyst premix is then siphoned into the main vessel, containing the heated core particles, at rate that ensures no clumping or agglomeration of the particulates. Once even coating has been achieved, the main vessel is heated to an average temperature of about 80° C., then cooled back down to room temperature (about 20° C.-28° C.). The coated material is then passed through a 45 ?m sieve to remove any large particulates that may be present.

Abstract: The present invention is directed to a method of reduction of frizz and improving hair conditioning wherein a hair treatment composition comprising a silicone emulsion with droplets having an average diameter of less than about 50 nanometers in an carrier wherein the silicone emulsion comprises a crosslinked organopolysiloxane made from various reactive compounds, wherein each compound is comprised of one or more units represented by the following general formula: R1nR2mR3p(OR4)qSiO[4-(m+n+p+q)]/2 where R1 is morpholinomethyl having the structure: R2 is —(CH2)3—NH—(CH2)2NH2 —(CH2)3—NH2 R3 is methyl R4 is hydrogen, methyl, ethyl or propyl n is 0, 1, or 2 m is 0, 1, or 2 p is 0, 1, or 2 q is 0, 1, 2 or 3 n+m+p+q is less than or equal to 3 and wherein the crosslinked organopolysiloxane comprises on average at least one radical R1 per molecule and wherein the method comprises the following steps: a) applying the hair treatment composition to hair by spraying or spreading; b) allowing hair to dry by a

Abstract: A skin care composition is provided that has an oil phase mixture and a water phase. The oil phase mixture has from about 5% to about 30% by weight of the composition, of a wax material and optionally from about 1% to about 20% by weight of the composition, of an oil that is liquid at room temperature. The oil phase mixture has a melting point of about 25° C. to about 50° C. The water phase has from about 0.1% to about 5%, by weight of the composition, of a superabsorbent polymer and from about 20% to about 85% by weight of the composition of water. The composition also has from about 6% to about 30%, by weight of the composition, of particulate material selected from the group consisting of starch particles, silicone elastomer particles and combinations thereof.

Abstract: The invention relates to methods for treating hair graying. More specifically, the present invention discloses new methods for reducing, stopping and/or reversing of hair graying in mammals by stimulating stem cell migration to produce or stimulate melanocytes in hair follicles. The invention further teaches a stem cell mobilizing composition for treating graying hair in a subject, comprising blue-green algae, which stimulates stem cell mobilization and growth of melanocytes in hair follicles.

Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a lignin oligomer, wherein the lignin oligomer: (a) comprises less than 1 wt % sulphur content; (b) has a number average molecular weight (Mn) of from 800 Da to 1,800 Da; and (c) has a molar ratio of aromatic hydroxyl content to aliphatic hydroxyl content in the range of from 1.2 to 1.9, wherein the consumer goods product ingredient is an emulsifier, and wherein the lignin oligomer is in the form of an emulsion, and wherein the consumer goods product is selected from skin treatment composition, oral care treatment composition, and detergent composition.

Abstract: A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.

Abstract: The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 ?m, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

Abstract: A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and emollient (preferably hygroscopic emollient) to balance. When topically applied to a wound and water from the surrounding environment diffuses into the composition, the hydrogen peroxide generator and/or the alkaline compound diffuse into one another, causing a chemical reaction that generates treatment-effective amounts of oxygen to occur. The oxygen can then diffuse out of the composition and aid in wound treatment or healing.

Abstract: Devices and methods for manufacturing and using microstructure arrays are described. In the methods, formulation is introduced into cavities of a microprojection array mold by means that include a vacuum to achieve a more efficient and uniform filling of the cavities and/or reduce bubble formation in the cavities.

Abstract: A composition for treating atopic dermatitis in animals containing active compositions of ceramides for skin barrier protection, omega 3 and omega 6 fatty acids for reducing pruritus and botanical extracts for inhibiting 5-lipoxygenease activity, histamine release while modulating the immune system. The active compositions are placed in a soft dough oral delivery system.

Abstract: A chewing gum with a liquid-fill composition and a surrounding gum region, with one or both containing active ingredients, such as herbal, medicinal and/or mineral elements or combinations thereof, present in an amount of at least about 0.05 mg.

Abstract: The present invention generally relates to dosage forms for oral administration including one or more gelling agents. In particular, the present invention is directed to gelling agent-based dosage forms that are easily administered and taken, or swallowed. The present invention is also directed to gelling agent-based dosage forms that exhibit relatively low syneresis, are thermally stable, exhibit substantially constant active ingredient concentration, and/or exhibit one or more advantageous rheological properties. In particular, the present invention is directed to such gels containing one or more omega-3 fatty acids. The gelling agent-based dosage forms of the present invention are suitable for administration of a relatively large dose of active ingredient. The gelling agent-based dosage forms of the present invention are also suitable for administration of multiple active ingredients.

Abstract: The present invention relates to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

Abstract: The invention includes compositions and methods for treating cancer comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, methods of inhibiting the growth of cancer stem cells or tumor initiating cell comprising administering to a subject in need a pharmaceutically effective amount of a pharmaceutical composition for inhibiting cancer stem cells. The pharmaceutical composition includes various combinations of sulforaphane, resveratrol, mangostine, honokiol, diallyltrisulphide and gemcitabine.

Abstract: In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low-solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.

Abstract: A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).

Abstract: The present invention relates to a pharmaceutical composition comprising a) a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, b) one or more, e.g. 1, 2 or 3, surfactants with lubricant properties; c) one or more, e.g. 1, 2 or 3, dry binders with disintegrant properties; d) one or more, e.g. 1, 2 or 3, fillers, and e) one or more, e.g. 1, 2 or 3, disintegrants.

Abstract: The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics.

Abstract: Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.

Abstract: Therapeutic formulations are described for use in the treatment of chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis, chlorine inhalation, influenza and acute myocardial infarction. The formulations comprise polymeric nanoparticles or polymeric nanoparticles encapsulated within cross-linked polymeric hydrogel microparticles, wherein the polymeric nanoparticles carry a therapeutic agent suitable for treatment of chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis, chlorine inhalation, influenza, acute myocardial infarction and heart failure. Preferred formulations are inhalable, dry powder therapeutic formulations, which are able to swell on administration to the lungs of a patient.

Abstract: The present invention relates to lamellar encapsulated nano-particles comprising at least one liquid crystalline emulsifier membrane around an inner core, wherein the inner core is solid below 30° C. and comprises at least one substance selected from the group consisting of lipids, waxes and/or polymeric substances, wherein the particle size is ?100 nm and ?800 nm and the average packing parameter of the emulsifier in the liquid crystalline membrane is ?0.3 and ?0.9.

Abstract: The present invention provides methods and compositions for treating hepatocellular carcinoma (HCC) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating HCC comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent, such as an agent that inhibits microtubule disassembly.

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

Abstract: Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.

Abstract: A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.