Abstract: Disclosed are a micelle containing bubbles for drug delivery and a method for manufactuing the same. The micelle formed according to the present invention includes microbubbles fromed by evaporating the liquiefied inert gas due to the irradiation of ultrasonic waves to a solution in which the liquefied inert gas is mixed with a drug for disease treatment, and the micelle is formed as a unit structure in which the microbubbles are contained in a cavity and the cavity is enclosed in a shell, and delivers the drug to the human body. Therefore, the micelle can protect a material of the drug, which is delivered to the human body, as well as deliver a larger amount of the drug than the existing technique, and can be easily applied to the treatment of various diseases.

Abstract: The present invention relates to the field of radiochemistry, nuclear imaging, radionuclide therapy and chemical synthesis. More particularly, it concerns a strategy for radiolabeling target ligands. It further concerns methods of using those radiolabeled ligands for imaging, radionuclide therapy and tissue-specific disease imaging.

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma.

Abstract: The invention provides an apparatus and a process for continuous virus inactivation. The apparatus for continuous virus inactivation in a product stream comprises a tube or hose 1 having an inlet 4 and an outlet 5 in each case connected to a product flow line 8 for conveying the product stream, where the tube or the hose 1 is curved and/or helically coiled with a number n of windings around a coil axis h and has one or more changes in direction and/or bends 2 in the coil axis h having an angle ? of from 45° to 180° to alter the direction of action of the normals of the centrifugal force and the apparatus is characterized by a Dean number>0 and a torsion parameter>0.

Abstract: Inner and outer surfaces of a container which is filled with drink are sterilized. A sterilizer is applied to an outer surface of a container (2) by blasting the sterilizer toward the outer surface of the container from at least one nozzle for sterilizer (26a-26d) disposed so as not to intersect with a mouth portion (2a) of the container, an inner surface of the container is sterilized by heat of a hot-water supplied into the container from a nozzle for hot-water, and the sterilizer adhering to the outer surface of the container is activated with the heat transferred from the hot-water to thereby sterilize the outer surface of the container.

Abstract: A lighting device configured to deactivate dangerous pathogens (e.g., MRSA bacteria) in an environment. The lighting device includes at least one lighting element configured to provide light. At least a first component of the light comprising light having a wavelength of between 400 nm and 420 nm, and at least a second component of the light comprising light having a wavelength of greater than 420 nm. The first component of light has a minimum integrated irradiance of 0.05 mWcm2 measured from any unshielded point in the environment that is 1.5 m from any point on any external-most luminous surface of the lighting device.

Abstract: A lighting device configured to deactivate pathogens in an environment. The lighting device includes at least one first light-emitting element configured to emit light having a wavelength of between 400 nm and 420 nm, wherein the light emitted by the at least one first light-emitting element is configured to deactivate the pathogens in the environment. The lighting device also includes at least one second light-emitting element configured to emit light having a wavelength of greater than 420 nm. A first combined light output of the light emitted by the at least one first and the at least one second light-emitting elements includes visible light that is perceived as white light. The white light has properties that make it visually appealing and unobjectionable.

Abstract: A method of providing doses of light sufficient to deactivate bacteria throughout a volumetric space. The method includes: (1) receiving data associated with a desired illuminance level for the space, indicative of an estimated occupancy of the volumetric space over a pre-determined period of time, and indicative of dimensions of the space; (2) determining, based on the received data, an arrangement of one or more lighting fixtures in the volumetric space, the one or more lighting fixtures configured to at least partially emit disinfecting light having a wavelength of between 400 nm and 420 nm, and a total radiometric power to be applied via the one or more lighting fixtures to produce a desired power density at any exposed surface within the volumetric space during the period of time; and (3) installing the determined arrangement of one or more lighting fixtures in the volumetric space.

Abstract: Methods of reducing the incidence of healthcare-associated infections in various healthcare settings are provided. Methods for preventing or reducing the number of infections in a human or animal population are also provided. The methods as provided herein reduce the presence of various infectious agents that are commonly acquired or transmitted and are present on both animate and inanimate surfaces, including those infectious agents commonly found in healthcare settings. By reducing the presence of such infectious agents, the incidence of various types of infection or disease is thereby reduced.

Abstract: A portable light fastening assembly for use with the human interface of an electronic device includes a lamp housing and an adjustable attachment device extending from the lamp housing. An ultra-violet (UV) light source is at least partially enclosed in the lamp housing such that the adjustable attachment device includes an engagement member and a receptacle housing such that the engagement member can be removably fastened within the receptacle housing for holding the lamp housing in a fixed position.

Abstract: Sanitizing surfaces in a location related to aircraft. There are multiple rows of seats. A sanitization device includes a mobile body configured to travel along the aisle of the aircraft. An arm extends from the sanitization device laterally from the mobile body across the seats, and a source of UV radiation mounted on the sanitization device is directed across the seats exposing surfaces in the passenger area to UV radiation. There is a data collector to collect information in the aircraft. A passive RFID tag mounted on elements can be read by an RFID reader. The device can include one or more sniffer cells for scanning the aircraft for unwanted or dangerous devices or chemicals.

Abstract: Provided are a sterilization apparatus including a sterilization chamber, a vacuum pump connected to one side of the sterilization chamber, a vaporizer connected to another side of the sterilization chamber, and a collector having one side connected to the vaporizer and the other side connected to the sterilization chamber and a sterilization method using the sterilization apparatus. In the sterilization apparatus and the sterilization method, a hydrogen peroxide solution having a concentration of 95 wt % or higher may be obtained through multiple concentration steps and used as a sterilant, thereby considerably improving a sterilization effect.

Abstract: An aroma diffuser using an aroma capsule is disclosed to include a hollow housing including a first opening on a top side thereof, a second opening on a bottom side thereof and an integrated holder member downwardly inwardly extended from a top side thereof and defining therein a holding chamber facing toward the first opening, a heat conduction device mounted in the holding chamber, and a heating element mounted at a bottom side of the heat conduction device and kept in contact with the heat conduction device. Thus, an aroma capsule can be placed in the holding chamber and heated by the heating element to release fragrant vapor. After the aroma contained in the aroma capsule is used up, the aroma capsule can be replaced conveniently and rapidly.

Abstract: A lamp-based aroma diffuser using an aroma capsule is disclosed to include a lamp housing, a hollow light-transmissive shade mounted in the lamp housing, a holder member mounted in the lamp housing, a heat conduction device mounted in the holder member, a heating element kept in contact with the bottom wall of the heat conduction device, a light-emitting device, and a power supply device-incorporated PC board for driving the heating element to heat the heat conduction device and a replaceable aroma diffuser in the heat conduction device and the light-emitting device to emit color light through the hollow light-transmissive shade and the lamp housing.

Abstract: An apparatus for air flow generation for scent output is described. The device includes a scent system, a speaker, and an output channel. The scent system and the speaker share the output channel, and the speaker is to move air to release scent from the device. A membrane of the speaker may vibrate to produce the air flow.

Abstract: Provided is a water-absorbing agent which is less likely to cause gel blocking and is suitable for a sanitary product and an absorbent article each being thin and containing a large amount of a water-absorbing agent, and which, while maintaining or hardly losing the other physical properties (a fluid retention capacity and a bulk specific gravity) of the water-absorbing agent, simultaneously achieves a high water absorbing speed (e.g., FSR), a high fluid retention capacity under load, high liquid permeability, and salt tolerance. The water-absorbing agent is a polyacrylic acid (salt)-based water-absorbing agent whose surface and its vicinity are crosslinked by an organic surface crosslinking agent, characterized by satisfying the following (A)-(D): (A) Free Swell Rate (FSR) of at least 0.

Abstract: The invention relates to methods for fabricating a flowable hemostatic composition. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.

Abstract: A pulverulent semisynthetic material, derived from a natural marine biomaterial, namely the aragonitic inner layer of the shell of bivalve molluscs selected from the group including Pinctadines, notably Pinctada maxima, margaritifera, and Tridacnes, notably Tridacnagigas, maxima, derasa, tevaroa, squamosa, crocea, Hippopushippopus, Hippopusporcelanus, in pulverulent form, with addition of insoluble and soluble biopolymers and calcium carbonate transformed by carbonation; it also relates to the method of preparation thereof and to the uses thereof.

Abstract: The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis.

Abstract: To cover shortages of existing PMMA bone cement products, including very high hardness and poor biocompatibility, the invention provides a mineralized collagen incorporated PMMA bone adhesive and filling material. Mineralized collagen (MC) is prepared via an in vitro biomimetic mineralization process and has a chemical composition and structure of self-assembled nano-sized calcium phosphate and collagen molecules, thus possessing biomimetic mineralized structure and mechanical properties similar to natural human bone, good biocompatibility, osteogenic activity and biodegradation ability. An MC incorporated bone adhesive and filling material with high compressive strength and low elastic modulus, and improved biocompatibility compared to pure PMMA bone cements may be obtained.

Abstract: The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.

Abstract: This disclosure provides a method for reducing or preventing the formation and/or accumulation of drusen in an eye of a mammalian subject in need thereof, the method comprising implanting one or more microporous devices into the eye, each device having a device body and an outer surface, wherein the microporous device is formed of a biocompatible elastomeric material and comprises a plurality of interconnected pores throughout the device body.

Abstract: Methods of fabricating a stent are disclosed including forming a primer layer on a surface of the scaffold including a first polylactide polymer. The primer layer includes a second polylactide polymer and is free of a therapeutic agent. The scaffold with the primer layer is thermally treated to condition the scaffold. A therapeutic layer is formed over the primer layer and the therapeutic layer includes the second polylactide polymer and a drug. The scaffold is crimped and the primer layer improves adhesion of the therapeutic layer to the scaffold and reduces or prevents damage to the therapeutic layer during crimping.

Abstract: Provided is a method for preparing a medical device which has a surface lubricating layer on a surface of a substrate and the surface of which exhibits lubricity and antithrombotic qualities when being wet. The method includes forming a coating layer that contains a hydrophilic polymer having at least one reactive functional group selected from the group consisting of an epoxy group, an acid chloride group, and an aldehyde group, and then applying onto the coating layer an antithrombotic material solution that contains an antithrombotic material having a functional group capable of binding to the hydrophilic polymer to form the surface lubricating layer. The concentration of the antithrombotic material in the antithrombotic material solution is more than 0 and less than 0.1 wt %.

Abstract: An apparatus for use in a multi-orientation liquid collection canister to collect liquid from a tissue site is provided. The apparatus includes a substantially planar, liquid-air separator disposed on at least one wall of the multi-orientation liquid collection canister to prevent the liquid from exiting the multi-orientation liquid collection canister. The apparatus further includes an elongated member connected to the liquid-air separator and extending away from the liquid-air separator into a first space of the multi-orientation liquid collection canister. The elongated member has a membrane defining a second space along at least a portion of a length of the elongated member. At least a portion of the membrane allows gaseous communication between the first space and the second space.

Abstract: Tissue collection systems and methods are provided. More particular, a modular system including one or more manifold elements is provided. Each manifold element includes a manifold barrel and a coupler to which a syringe body can be connected. An inlet of a first manifold element is connected to a first manifold cap having an inlet orifice. A second manifold cap having an outlet orifice is connected to the outlet of the first manifold element or to the outlet of a second manifold element. The manifold barrel can include a barrel inlet that is offset from a barrel outlet.

Abstract: An oral negative-pressure therapy system includes a container and absorbent insert for the container. The container includes a baffle inside an interior of the container. A fluid passageway extends along the baffle for delivering fluid (e.g., a mixture of air and saliva) into the container. The absorbent insert for absorbing liquid (e.g., saliva) in the container may is over the baffle. At least one of the baffle and the absorbent insert is configured to maintain a fluid flow path between the baffle and the absorbent insert to maintain fluid communication between a fluid inlet and a fluid outlet of the container. The absorbent insert and/or the container may be designed and constructed to burst air bubbles in the aspirated liquid. In one or more embodiments, the absorbent insert is replaceable so that a spent absorbent insert can be replaced with a new, fresh absorbent insert.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: Disclosed is an apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir (11) of an autologous blood transfusion system (20), comprising sensing means (10, 12) for periodically sensing the liquid level of the salvaged blood in said blood collection reservoir (11) and outputting corresponding signals, and determining means (2) for determining the liquid level of the salvaged blood in said blood collection reservoir (11) based on said output signal of said sensing means. The sensing means comprises a plurality of light emitters (12) disposed on a first side of said blood collection reservoir (11) at different height levels (L1-L9) for emitting light and a plurality of light receivers (10) disposed at said different height levels (L1-L9) on a second side of said blood collection reservoir (11) opposite to said first side for sensing light emitted by said light emitters (12) and transmitted through said blood collection reservoir (11).

Abstract: The present invention relates to a transcatheter method for providing fluid communication between two anatomical compartments. The present invention also relates to a transcatheter system comprising an intracorporeal connector for fluid communication between two anatomical compartments through at least one anatomical wall, wherein said connector is adapted to receive a flow regulating device, a connector, a flow regulating device and an insertion device.

Abstract: Blood pumps for ventricular assist devices employ a hollow rotor to impel blood through the blood pump. A blood pump includes a housing having a housing inlet, a housing outlet, and a housing blood flow channel through which the housing inlet and the housing outlet are in fluid communication. A motor stator is disposed around the housing blood flow channel and operable to generate a rotating magnetic field. A hollow rotor is disposed within the housing blood flow channel and rotated via the rotating magnetic field. The hollow rotor has a rotor circumferential wall enclosing a rotor blood flow channel. The hollow rotor has at least one rotor blade extending inwardly from the rotor circumferential wall. The at least one rotor blade is configured to impel blood through the rotor blood flow channel when the hollow rotor is rotated via the rotating magnetic field.

Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.

Abstract: A dialysis system includes at least one source of fluid for dialysis, a fluid line in fluid communication with the at least one source of fluid, at least one pump positioned and arranged to pump fluid from the at least one source of fluid through the fluid line, a first patient connector configured to be removably placed in fluid communication with the fluid line to allow a blood treatment to be performed using the at least one source of fluid, and a second patient connector configured to be removably placed in fluid communication with the fluid line to allow a peritoneal dialysis treatment to be performed using the at least one source of fluid.

Abstract: Described are peritoneal dialysis systems and methods that involve the use of first and second stage filtration of a used dialysate withdrawn from the peritoneal space of a patient. The first filtration stage forms a first retentate containing an osmotic agent and a first permeate containing water and nitrogen-containing waste products of the patient. The second filtration stage acts on the first permeate to form a second retentate containing nitrogen-containing waste products of the patient and a second permeate containing water. At least some of the water from the second permeate is combined with the first retentate to form a regenerated peritoneal dialysis medium containing an amount of the osmotic agent. The regenerated peritoneal dialysis medium can be returned to the peritoneal space of the patient.

Abstract: A hemodialysis wand holder includes a container having a plurality of side walls configured to form an open top end and a cavity extending downwardly from the open top end. A lid is removably coupled to the open top end wherein the lid has at least one aperture formed therein. At least one hemodialysis wand is removably inserted through the at least one aperture such that the at least one hemodialysis wand is suspended above a bottom one of the side walls. A collection tray is adjustably situated along the bottom side wall. Such a collection tray is removably reciprocated along a linear travel path registered transverse to a front one of the side walls. A fluid-absorbent liner is removably positioned within the collection tray for receiving fluids dripping down from the at least one hemodialysis wand suspended partially within the cavity.

Abstract: An assembly structured for concurrent irrigation and aspiration of a nasal cavity including a housing having a supply container disposed therein for the removable retention of irrigating fluid. A nasal applicator comprises first and second passages respectfully structured to deliver irrigating fluid to the nasal cavity and concurrently remove waste fluid therefrom. An activating assembly includes a plunger biased into a continuous pressure applying, dispensing relation to the irrigating fluid and a valve assembly is selectively disposable into an open position facilitating fluid communication between the supply container and the applicator for the delivery of the irrigating fluid therethrough into the nasal cavity. The activating assembly is further structured to create a negative pressure within the chamber which communicates with the second passage of the applicator to facilitate delivery of the waste fluid therefrom along a path of travel to an interior of the chamber.

Abstract: A kit to facilitate creation of and compliance with a personalized injection site rotation plan includes a plurality of disposable injection devices adapted for giving an injection of a medication to a patient in need thereof, each disposable injection device having a permanent, distinctive mark that may be the same as or different from the distinctive mark on other disposable injection devices in the kit; and a plurality of user-defined association tools, wherein for each unique distinctive mark on a disposable injection device, at least one user-defined association tool has a distinctive mark that corresponds to the unique distinctive mark.

Abstract: A method of calculating a volume of a drop pendant using a microprocessor. Included in the method are generating a gravity vector based on a direction of gravity with respect to the drop pendant; establishing a reference frame of the drop pendant for an image processing based on a reference point of the drop pendant and the gravity vector; generating a first reference line associated with the reference frame for representing an actual orientation of the drop pendant; generating a second reference line associated with the reference frame for representing a longitudinal axis of a chamber in which the drop pendant is located; comparing the first and second reference lines with respect to the gravity vector; and calculating the volume of the drop pendant based on the comparison of the first and second reference lines and the gravity vector.

Abstract: An autoinjector comprising a body (1) and an actuator sleeve (10) that is movable relative to said body (1), said actuator sleeve (10) being in a first projecting position before actuation of the autoinjector, and in a second projecting position after actuation of the autoinjector; one of said actuator sleeve (10) and of said body (1) including a flexible tab (110) that is adapted to deform laterally relative to said actuator sleeve (10) and/or relative to said body (1) when said actuator sleeve (10) is moved from its first projecting position to its actuated position, then from its actuated position to return to its second projecting position, the other of said actuator sleeve (10) and of said body (1) including an initial zone (102) that co-operates with said flexible tab (110) in said first projecting position, an intermediate zone (105) that co-operates with said flexible tab (110) in said actuated position, and a final reception zone (106) that co-operates with said flexible tab (110) in said second proj

Abstract: In an embodiment, the present invention provides an autoinjector that has one or more slip-resistant features. In certain embodiments, the exterior surface of the autoinjector housing forms at least one of indentures and protrusions that impart a slip-resistant texture to the housing of the autoinjector. In other embodiments, the one or more slip-resistant features are included on a label, which comprises a label substrate and is attached to the exterior surface of the housing of the autoinjector. The features are designed to improve the handling properties of the autoinjector and reduce the likelihood that the autoinjector will slip out of a user's or caregiver's hand during use.

Abstract: Injection device comprising a tubular elongated main body, a needle shield slidably arranged in said main body, a needle shield link slidably connected to said needle shield, a enclosure containing medicament arranged in said main body, a needle connected M said enclosure, a plunger operatively arranged to said enclosure for ejecting said medicament through said needle and arranged on its upper part with a number of outwardly extending stop members, spring means arranged to said plunger for operating said plunger, a dose activating means, a needle shield spring surrounding the needle shield link.

Abstract: A needle assembly for a hypodermic syringe is disclosed herein. In various aspects, the needle assembly includes a hub and a needle. A bond secures the needle to the hub, and the bond is configured to break allowing the needle to be withdrawn entirely from the hub upon application of a selected axial force to the needle, in various aspects. The axial force may be less than the tensile strength of the needle. Related methods of use of the needle assembly apparatus are disclosed herein. This Abstract is presented to meet requirements of 37 C.F.R. §1.72(b) only. This Abstract is not intended to identify key elements of the apparatus and the related methods disclosed herein or to delineate the scope thereof.

Abstract: The invention relates to a boot remover (10) for removing a protective needle boot (11) from a drug delivery device (1), wherein the boot remover (10) is arranged to engage the protective needle boot (11) when attached to the drug delivery device (1), wherein the boot remover (10) comprises a tab (10.2) extending in a distal direction (D), wherein the tab (10.2) is engageable to a packaging (13) of the drug delivery device (1). Furthermore, the invention relates to a drug delivery arrangement comprising a drug delivery device (1), a packaging (13) and the boot remover (10).

Abstract: Methods for removing a covering cap from a syringe needle and for recapping the needle, using a protection device with improved functionality, particularly for syringes, comprising a supporting body which is provided with a through hole for the insertion of the covering cap of a needle of a syringe, the supporting body being provided with at least one flat face, being arranged on the opposite side with respect to a face for the insertion of the covering cap in the hole, for the resting contact of the supporting body on a resting surface, the face lying opposite the flat face being provided with a raised perimetric containment rim, the hole having a diameter that is substantially larger than the diameter of the central portion of the covering cap and substantially smaller than the diameter of the end portion of the covering cap, a collar being provided around the hole, the collar extending from the face for the insertion of the covering cap.

Abstract: An apparatus for storing, warming and manually individually dispensing elongated cylindrical vials having different contents, while minimizing error and clutter, is described. Vials are stored in bins, which have manually operated dispensing members. Each bin may be separately heated using small incandescent bulbs or other heating elements. Adjustable temperature sensors may be placed in each bin to permit separate temperature control, and provide a high-temperature cutoff. One embodiment of the apparatus may be wall mounted to relieve congestion on horizontal surfaces. Another embodiment is suitable for table use, and has a reduced profile for clutter reduction.

Abstract: The present invention is directed to a device for the expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the reservoir between the bellows and plunger and the expression port, and a spring is disposed within the reservoir between the air pump and the plunger. The powder is disposed within the reservoir between the porous filter and the expression port, and the pump is in a fluid communication with the expression port through the porous filter and through the powder.

Abstract: The present invention relates to a nebulizer mesh which is used, in a nebulizer for atomizing and nebulizing liquid, for atomizing the liquid, and has plural through holes 17, wherein each of the through holes 17 forms a cylindrical space portion 174 on one surface side of the nebulizer mesh, and forms an opening 172 opened in a mortar shape on the other surface side, and to a production method thereof.

Abstract: Systems and methods are provided for anesthetizing a tympanic membrane of an ear. The systems are personalizable to ensure proper anesthetizing solution administration. The systems and methods may also be useful for administering a solution to the ear canal of a human patient and for maintaining the solution therein.

Abstract: A nasal inhaler band comprising a strip of air-permeable material to be worn under the nose, whereby such strip holds a vapor-releasing material which releases vapors to a user's nasal openings. Such nasal inhaler band can be worn quasi-permanently by patients, to relieve symptoms of restricted nasal patency or symptoms of air hunger (dyspnea).