Abstract: Disclosed is a method for the non-destructive testing of workpiece surfaces of a workpiece by means of fluorescent penetrant testing or dye penetrant testing. The method comprises applying a penetrant to the region of the workpiece surface to be examined, thereby allowing the penetrant to penetrate into possible recesses in the workpiece surface, applying a developer to the region of the workpiece surface to be tested; bleaching the penetrant by a gaseous or liquid oxidant; and visually assessing the penetrant that has remained in the recesses present in the workpiece surface.

Abstract: In inspecting a substrate having a transparent oxide film or a metal film formed on a surface thereof by using a dark field type inspection apparatus installing a laser light source, an illuminating beam having a high coherence causes variations in reflection strength due to multiple interferences within the transparent oxide film or an interference of scattered beams due to the surface roughness of the metal film occurs and which leads to degradation in the sensitivity of defect detection. The present invention solves the problem by providing a low-coherence but high-brightness illumination using a highly directive broadband light source, and a system in which the conventional laser light source is simultaneously employed to selectively use the light sources, thereby enabling a highly sensitive inspection according to the condition of a wafer.

Abstract: A system, including an illumination module that comprises (a) a first traveling lens acousto-optic device; (b) a light source for illuminating the first traveling lens to provide an input beam that propagates along a first direction; (c) illumination optics for outputting an output beam that scans the object at a second direction; a detection unit; and a collection module for collecting a collected beam from the object, wherein the collected beam propagates along a third direction; and optically manipulating the collected beam to provide a counter-scan beam is directed towards the detection unit and has a focal point that is positioned at a same location regardless of the propagation of the collected beam along the third direction.

Abstract: A pattern inspection method includes acquiring an image of a pattern in a stripe region concerned, regarding each of stripe regions of the first group each not including an adjacent stripe region in plural stripe regions obtained by virtually dividing an inspection region of a target object on which patterns have been formed into the plural stripe regions each partially overlapping an adjacent stripe region, wherein the acquiring is performed using laser lights or electron beams, in a longitudinal direction of the stripe region of the first group, and acquiring an image of a pattern in a stripe region concerned, regarding each of stripe regions of the second group each not including an adjacent stripe region, in remaining stripe regions other than the first group stripe regions, wherein the acquiring is performed using laser lights or electron beams, in the longitudinal direction of the stripe region of the second group.

Abstract: A volumetric imaging device for constructing a three dimensional image includes a source, and absorbing detector, and an image constructor. The source includes a photon source, and a scatter detector arranged between the object and the photon source. The photon source emits photons towards the scatter detector. The scatter detector scatters at least some of the photons and detects the scattered photons. The object scatters at least some of the photons that were first scattered by the scatter detector. The absorbing detector is arranged to detect scattered photons from the object. The image constructor constructs the three dimensional image based on the scattered photons.

Abstract: The invention relates to a device for identifying a material of an object having: a source of X photons and a spectrometric detector, the source irradiating the object with an incident beam and the detector measuring a magnitude of a backscattered beam from the incident beam after diffusion in a volume of the material and an energy of the X photons of the backscattered beam, the incident and backscattered beams forming an angle of diffusion (?); a configuration for adjusting the position between the source, the detector and the object in order for the volume to be at different depths with a constant angle, a means for processing the two magnitudes in two positions and the energy in on position and for calculating an attenuation factor (?materiau (E0, E1, ?)), a configuration for estimating the density (p) of the material.

Abstract: Structural parameters of a specimen are determined by fitting models of the response of the specimen to measurements collected by different measurement techniques in a combined analysis. X-ray measurement data of a specimen is analyzed to determine at least one specimen parameter value that is treated as a constant in a combined analysis of both optical measurements and x-ray measurements of the specimen. For example, a particular structural property or a particular material property, such as an elemental composition of the specimen, is determined based on x-ray measurement data. The parameter(s) determined from the x-ray measurement data are treated as constants in a subsequent, combined analysis of both optical measurements and x-ray measurements of the specimen. In a further aspect, the structure of the response models is altered based on the quality of the fit between the models and the corresponding measurement data.

Abstract: A method for imaging a target with an x-ray scatter apparatus. Air scatter from air intervening between the x-ray scatter apparatus and a target overwhelms x-ray scatter from the target in that x-ray scatter from a position on the target is no more than 10% of the x-ray scatter due to intervening air scatter that reaches at least one point in the detector plane of the x-ray scatter apparatus. The target is illuminated with a beam of x-rays scanned across the target, and x-rays scattered by the target are detected using a detector with a centroid displaced with respect to the beam axis by at least five feet. The detector signal is then processed to generate an image of the target. The beam of x-rays may be unshielded, and/or the detector may be uncollimated.

Abstract: Described herein is a method for analyzing an object using a particle beam apparatus, for example an electron beam apparatus and/or an ion beam apparatus, or using an x-ray beam device and a particle beam apparatus or an x-ray beam device, by means of which the method is carried out. In the method, information about the object is loaded from a data memory into a control device. Furthermore, a group of detection units from the multiplicity of detection units is identified using the information loaded into the control device. A first detector segment is formed from the group of detection units using the control device. Interaction particles and/or interaction radiation, which is/are detected, is/are generated by guiding a particle beam onto the object and scanning the object using the particle beam, where a detector segment signal is read from the detector segment.

Abstract: A sensor apparatus and sensor apparatus system for use in conjunction with a cassette, including a disposable or replaceable cassette. In some embodiments, the cassette includes a thermal well for permitting the sensing of various properties of a subject media. The thermal well includes a hollow housing of a thermally conductive material. In other embodiments, the cassette includes sensor leads for sensing of various properties of a subject media. The thermal well has an inner surface shaped so as to form a mating relationship with a sensing probe. The mating thermally couples the inner surface with a sensing probe. In some embodiments, the thermal well is located on a disposable portion and the sensing probe on a reusable portion.

Abstract: A system for detecting moisture characteristics of a material of a complex structure while the material is in situ or forms part of the complex structure. The system includes at least one moisture detection sensor positioned proximate the material of the complex structure while the material is in situ. The system also includes a controller in data receiving communication with the moisture detection sensor.

Abstract: An analyte test sensor for use in measuring the concentration of a particular analyte in a test sample includes a non-conductive substrate, a reference electrode deposited on the substrate, a working electrode deposited on the substrate and a compensation electrode deposited on the substrate. The compensation electrode is provided with a resistive ladder and is designed to correct for test result inaccuracies which are the result of variances in the manufacturing of the test sensor. Specifically, in one embodiment, the compensation electrode corrects for test result inaccuracies in an analog manner by shunting a portion of the working current away from working electrode. In another embodiment, the compensation electrode corrects for test result inaccuracies in a digital manner by providing a calibration code which is proportional its resistance value. A batch of analyte test sensors are preferably manufactured in the following manner. An initial batch of the test sensors is constructed.

Abstract: A monitoring circuit for detecting degradation of a hose assembly a hose assembly and a hose assembly incorporating such a monitoring circuit are disclosed. The monitoring circuit includes a voltage source connected to a first connection location of a hose assembly. A capacitor is electrically connected between the second connection location connected to the second conductive layer of a hose assembly and a ground. The capacitor is selected such that a change in resistance of the hose assembly changes a voltage carried by the capacitor. The monitoring circuit includes a voltage sampling circuit configured to periodically detect a voltage at the capacitor. Upon detecting a change in the voltage above a predetermined threshold, the voltage sampling circuit generates an alarm indicative of potential failure.

Abstract: A probe assembly includes plural capacitive contacts that are separate from each other and a conductive depletion gate disposed between and separating the contacts from each other. The depletion gate is configured to receive a direct electric voltage to deplete regions of a sample under test of electrons. The contacts are configured to be placed in close proximity to a buried conducting layer in the sample under test without engaging the buried conducting layer, thereby capacitively coupling to the buried conducting layer. A first subset of the capacitive contacts is configured to apply an alternating electric current to a portion of the sample under test and a second subset of the capacitive contacts is configured to sense an alternating voltage response of the portion of the sample under test to characterize one or more electrical properties of the sample under test without the capacitive contact with the buried conductive layer.

Abstract: The present invention provides a system and apparatus for inspecting tendons and cable stays in bridges and structures using multi-frequency excitation of an ECVT sensor.

Abstract: Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.

Abstract: A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner.

Abstract: The invention relates to electrode chip (EChip) cartridge devices which are used in hot electron-induced electro-chemiluminescence (HECL) and electroluminescence (EL) methods and instrumentation based on the electrical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations in bioaffinity assays, especially outside of central laboratories, but also in rapid screening tests.

Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base with first and second ends, a concave recess in the first end, a second end receiving surface, and a sidewall extending between the ends. An electrode may be provided on the receiving surface with an electrochemically-active region coupled to the electrode. A conductor in electrical contact with the electrode may extend along the sidewall and may be adapted to be in electrical contact with a first contact of an analyte meter. Manufacturing methods and systems utilizing and dispensing the analyte sensors are provided, as are numerous other aspects.

Abstract: Embodiments include a method for securing a membrane material to a gate of a molecular receptor-based chemical field-effect transistor (CHEMFET). The method can include casting a membrane material onto an exposed region of the gate, curing the membrane material, placing the CHEMFET into a mold, inserting a single application of impervious electrically insulative resin into the mold, and securing edges of the membrane material by the single application of the impervious electrically insulative resin, thereby physically preventing lifting off of the membrane material from the gate. Embodiments include a sensor module. The sensor module can include a CHEMFET, an amplifier circuit, one or more sensor pins for contacting field ground soil, a data logger, and a wireless transceiver, among other components.

Abstract: The cartridge includes a sensor structure that has multiple sensors positioned on a substrate. The cartridge also includes a common channel defined in the substrate such that a fluid flowing in the common channel contacts each of the sensors as a result of the fluid flowing from an inlet of the common channel to an outlet of the common channel.

Abstract: The analysis method allows analysis of samples with high sensitivity, irrespective of interelectrode distance. The method includes: a step of applying a voltage between a first electrode pair such that an electric field is formed in a direction intersecting a migration direction of a sample; a step of placing a solution, including an electrochemically active molecule that produces a redox reaction at the electrode pair, between the first electrode pair; a step of causing the sample to migrate; and a step of measuring an amount of change in current flow between the first electrode pair.

Abstract: A suppressor is structured by an ion exchange section being structured by an eluate path forming member forming an eluate path and a regenerant path forming member forming a regenerant path being stacked across an ion exchange film, and a heat-conductive heat block covering the outside of the ion exchange section. A separation column, the suppressor, and an electrical conductivity meter are accommodated in a common constant temperature bath. The inside of the constant temperature bath is feedback-controlled by a temperature control section so as to be maintained at constant temperature.

Abstract: Provided are an analysis device and an analysis method. According to the device and the method, a giant magnetoresistance (GMR) sensor unit is formed to be the same as the size of one cancer cell or smaller and magnetic resistance according to the number of magnetic nano particles coupled with the one cancer cell by using the GMR sensor unit, thereby not only diagnosing cancer but also simply and cheaply distinguishing the type of the cancer.

Abstract: Provided are a multiple discrimination device and a method of manufacturing the same. According to the multiple discrimination device, a three-dimensional micro ferromagnetic pattern is optimally designed and arranged to allow a magnetic force applied to a discrimination-target particle to be discriminated to be well controlled to perform discrimination well. The method employs a semiconductor processing technology, thereby precisely manufacturing and allowing mass production.

Abstract: An inspection apparatus (100) for monitoring the structural integrity of a pipeline (101) comprising a superconducting electromagnet (102) suitable for generating a magnetic field (106); a cryostat (103) suitable for containing and preserving said superconducting electromagnet (102) at a low temperature; at least two magnetic conveyors (104?, 104?) connected at opposite ends of the cryostat (103) suitable for conveying the magnetic field (106) generated by the superconducting electromagnet (102) to the wall of the pipeline (101) and facilitating the closing of a magnetic circuit; at least one sensor system (105) for revealing the intensity of the magnetic field (106). A method for monitoring the structural integrity of a pipeline (101) using an inspection apparatus (100) according to the present invention.

Abstract: A sensor operable to sense a characteristic of a fluid. The sensor includes a sensing area, a filter, and a transducer. The sensing area is configured to contain the fluid. The filter covers the sensing area. The filter is configured to allow a liquid portion of the fluid to enter the sensing area and substantially prohibit a gas portion of the fluid to enter the sensing area. The transducer is operable to output a pulse of sound through the liquid portion of the fluid contained within the sensing area, receive the reflected pulse of sound, and output a characteristic of the fluid based on the received pulse of sound.

Abstract: A multiple frequency ping transmitter which can be carried by a pig which is used in an underwater pipeline. The ping transmitter produces a ping chord which includes a plurality of different tone frequencies which are simultaneously transmitted in the ping chord. Procedures are also provided wherein the multiple frequency ping transmitter is used in a system and method for located a pig which is stuck in the underwater pipeline or for determining the relative velocity of a moving pig.

Abstract: The invention relates to a method for testing connections of metal workpieces to plastic compounds for cavities by means of ultrasound, wherein the plastic compound is arranged between the workpiece as an intermediate layer or is connected to the workpiece on one side and the cavity is located within the plastic compound, wherein the cavity is connected to the workpiece by means of a remaining plastic layer or plastic skin and wherein the plastic compound is exposed to ultrasonic signals of a certain test frequency and pulse length from the metal side of the workpiece by means of at least one ultrasonic probe, and in particular the ultrasonic signals reflected by flaws in the plastic compound are detected by the same or another ultrasonic probe and converted into electrical signals that can be evaluated and subjected to a threshold observation. The test frequency of the ultrasonic signals is set in a range of 1 to 10 MHz so that the attenuation of the sound is minimal after passing through the plastic skin.

Abstract: A sonic speed measurement device in which reliability is enhanced while the amount of calculation is minimized is provided. A propagation path postulation component postulates the sonic speed through bone, and calculates propagation paths up until ultrasonic waves transmitted from a wave transmitter are received by oscillators. A postulated propagation time calculator calculates the propagation time it takes for the ultrasonic waves transmitted from the wave transmitter to be received by the oscillators, based on the propagation paths. A Fourier transform component subjects I signals and Q signals of signals outputted by the oscillators to Fourier transform to generate Fourier transform data. A phase shifter shifts the phase of the Fourier transform data for the oscillators in a frequency region according to the propagation time. A sonic speed derivation component determines the validity of the postulated sonic speed based on the Fourier transform data shifted by the phase shifter.

Abstract: Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column. Small samples are periodically taken from the first fluidic stream as it leaves the chromatography column and injected into a first branch of a second fluidic stream. Low molecular weight components detrimental to the efficient operation of the mass spectrometer are removed by an in-line dialysis cell. A second fraction of the second fluidic stream acts as the dialysate. In a second and preferred system provided in accordance with the present teaching, the first fraction of the second fluidic stream is further split downstream of the sampling mechanism through the use of a three-way connector. Approximately 0.3 to 5 microliters per minute continues through the dialysis cell and thereafter to the electrospray emitter of the mass spectrometer.

Abstract: Technologies are generally described for devices for detection of a biofilm by a color change in a moisture-indicating substance, such as a chemical or a dye. The moisture indicating material may be supported by a substrate and sealed to keep moisture from the moisture indicating material. Alternatively, the moisture indicating material may be supported in a pouch and sealed by the pouch. The color change results from an ingress of moisture accompanying growth of a biofilm. The moisture-indicating substance may be used with indwelling or other devices to detect a biofilm. When the biofilm has sufficiently degraded the seal, an ingress of moisture and its accompanying pH may cause a color change in the moisture-indicating substance to signify the presence of the biofilm. Methods of manufacture and use of the disclosed devices are also described.

Abstract: An aging environment measurement apparatus measures aging environment data within an oak barrel and transmits the measured aging environment data within the oak barrel to a server, and the aging environment measurement apparatus is mounted in a bung of the oak barrel.

Abstract: A temperature and pressure regulating biogas sample extraction system and method for providing a conditioned biogas sample for constituent analysis.

Abstract: Functionalized titanium nanotubes can be utilized to detect compounds of interest, for example peroxide-based explosives. The nanotubes may desirably be coated, for example with a silicon oxynitride coating, in order to improve detection performance and/or functionality in the presence of moisture, saline, or other conditions typically unfavorable to titanium nanotube detection devices and methods. Inexpensive, compact, reusable, and responsive sensors may be fabricated from the coated nanotubes.

Abstract: A method of providing an indication as to the amount of milk remaining in a breast during lactation based on a determined fat content of milk that has been expressed from said breast is disclosed. The method of determining said fat content comprises measuring an optical characteristic of milk following expression and by comparing said measured optical characteristic with data representing a corresponding optical characteristic of a sample of milk having a known fat content to determine the fat content of said expressed milk which is indicative of the amount of milk remaining in the breast.

Abstract: A method for determining the number of drops metered with a drop frequency into a reactor, especially in a high temperature decomposition system for analyzers, wherein a gas stream is flowing through the reactor. There exists in the reactor a temperature, which is greater than the boiling temperature of the liquid, and a drop metered into the reactor transforms at least partially into the gas phase following entry into the reactor, especially due to heat transfer from contact with a surface within the reactor, especially directly after contact with the surface within the reactor. With a sampling rate, which is greater than the drop frequency, a sequence of pressure signals dependent on pressure within the reactor is registered, and, from the sequence of pressure signals or from values derived therefrom, the number of drops metered into the reactor is ascertained.

Abstract: An analyzing arrangement for analyzing a composition of a fluid, such as oil mist of an engine, e.g. a gas turbine is provided. The analyzing arrangement includes a breather pipe coupleable to the gas turbine such that at least a part of the fluid is flowing through the breather pipe, a first collecting device for collecting a first sample of the fluid, wherein the first collecting device is configured for providing a first composition analysis of the first sample and a second collecting device for collecting a second sample of the fluid, wherein the second collecting device is configured for providing a second composition analysis of the second sample. The first collecting device and the second collecting device are arranged inside the breather pipe such that the first collecting device and the second collecting device are exposed to a common flow characteristic of the fluid inside the breather pipe.

Abstract: A fluid filtration system may include a fluid filter assembly that includes a filter element configured to filter a fluid and a sensor probe incorporated into the fluid filter assembly. The sensor probe may include a chemically reactive material sensitive to at least one property of the fluid and at least a portion of the sensor probe may be exposed to the fluid.

Abstract: An investment casting shell substrate sensor method and apparatus comprising a hollow probe 10 having an aperture 30, the aperture 30 covered by a water proof breathable membrane (WPBM) 20 that is constructed and arranged to repel liquid from entering the aperture 30, while remaining permeable so as to allow vapor and air to pass through the aperture 30, thereby creating a liquid free internal void 50 within the hollow probe 10 that receives a sensor 40 for measuring the conditions (i.e. temperature and humidity) within the internal void 50, which are accurately indicative of the conditions at the shell substrate at the aperture 30 location. The disclosed sensor assembly provides target specific information at selected substrates within the shell real time, during the shell building process.

Abstract: The present invention provides novel apparatuses and methods for isolating or recovering a subset of blood cells such as leukocytes and/or circulating tumor cells from blood samples by filtration without changing the intracellular concentration of a therapeutic agent such as an anticancer drug. Contrary to the art, the apparatuses and methods of the present invention advantageously provide cell lysates from recovered cells such as leukocytes and/or circulating tumor cells without substantial dilution of a therapeutic agent such as an anticancer drug.

Abstract: A system of measuring hemoglobin and bilirubin parameters in a whole blood sample using optical absorbance. The system includes an optical-sample module, a spectrometer module, an optical fiber module optically connecting the optical-sample module to the spectrometer module, and a processor module. The optical-sample module has a light-emitting module having a LED light source, a cuvette and a calibrating-light module. The processor module receives and processes an electrical signal from the spectrometer module and transforms the electrical signal into an output signal useable for displaying and reporting hemoglobin parameter values and/or total bilirubin parameter values for the whole blood sample.

Abstract: A body fluid testing apparatus, comprising a containing chamber having a first opening on the bottom wall thereof; a plunger chamber having a plunger contacting with the side wall thereof and having a second opening on the bottom wall thereof, wherein the plunger chamber is disposed below the bottom wall of the containing chamber and in communication with the containing chamber through the first opening; and a testing chamber having a testing card designed to contain test strips and perpendicular to the longitudinal axial of the plunger chamber, wherein the testing chamber is disposed next to the side wall of the containing chamber and in communication with the plunger chamber through the second opening. The device according to the present disclosure can carry out the test of the body fluid, even though it has no chamber on the plunger body.

Abstract: There are provided a composition for determining the efficacy of a c-Met antibody including marker genes and a method for determining the efficacy of a c-Met antibody using the marker genes.

Abstract: Devices and methods are provided for detecting an immune reaction to a test agent using an immune modeling system comprising a barrier component configured to culture a biological barrier, an immune component configured to culture immune cells, and one or more inter-component microfluidic connections between the barrier component and the immune component. The system provides for culturing a biological barrier in the barrier component of the system, culturing immune cells in the immune component of the system, applying the test agent to the biological barrier, and monitoring the immune cells to detect an immune reaction to the test agent.

Abstract: This invention relates to a method of screening agents for cardiotoxicity based on the observations of the alteration of heart rate and heart rhythm, using teleost embryos and larvae. This invention also relates to a method for identification of gene(s) related to cardiac functions in teleost.

Abstract: A flow chamber and method for detecting the presence of one more cell produced analytes under flow conditions. The flow chamber includes two compartments separated by a permeable membrane on which a plurality of cells may be positioned. The permeable membrane shields one or more analyte sensors positioned one compartment from the convective transport forces of a fluid flow within the other compartment to allow reliable and accurate detection of cell-produced analytes and determination of the concentration of cell-produced analytes.

Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

Abstract: Subject of the present invention is an in vitro method for therapy follow-up in septic patients wherein the concentration of mature ADM 1-52 and/or mature ADM 1-52-Gly in a sample of bodily fluid of said septic patient is determined using an assay comprising two binders that bind to two different regions within the region of mature adrenomedullin and/or adrenomedullin-Gly that is aminoacid 21-52-amid SEQ ID No. 1 or aminoacid 21-52-Gly SEQ ID No. 2 wherein each of said regions comprises at least 4 or 5 amino acids. Subject of the present invention are further assays and calibration methods.

Abstract: A three-in-one apparatus for analyzing liquids, such as some body fluids, uses labeled molecular affinity binding, such as immunochromatography. The multi-functional diagnostic test device can detect an analyte, such as an antibody or antigen, which may indicate a particular condition. The multi-functional diagnostic test device provides multi-functional formats to apply in multiple different sampling methods, including the “dip”, “cassette” and “collection” formats. The diagnostic test device can accommodate a plurality of test strips, such as 18 test strips for analyzing up to 90 analytes.