Abstract: A handheld moisture sensing device for use in determining the moisture content of biological material, such as animal feed. Adapted to be pressed against biological material to be analyzed, the device includes a sensor assembly, including a housing with an end structure including a grate adapted to engage the material to be examined, a near infrared (NIR) LED, an NIR light sensor, a glass mounted in the housing adjacent the light source so that light from the light source passes through the glass, a glass heater positioned adjacent the glass for heating the glass, a lens mounted in the housing adjacent the NIR sensor so that the NIR light reflected off the biological material passes through the glass and is focused by the lens onto the NIR sensor, and a controller connected to the NIR sensor and receiving a signal related to the reflected NIR light received by the NIR sensor.

Abstract: A measuring apparatus is capable of measuring chlorine dioxide gas concentration by correcting for changes in light emission of an LED due to heating and passage of time, and applying the correction to the optical absorption rate of chlorine dioxide gas at a photodetector. The measuring apparatus includes a main body with a measuring passage surrounded by a pair of transparent bodies, into which specimen gas or fresh air is fed and then discharged, and a comparing passage arranged in the vicinity of the measuring passage, into which no specimen gas is fed, first and second LEDs for emitting ultraviolet light which both have identical properties and are mounted at one end of the measuring passage and at one end of the comparing passage, respectively, and first and second photodetectors for receiving light respectively from the first and second LEDs and detecting a light emission amount thereof.

Abstract: The inventive concept provides apparatuses and methods for monitoring semiconductor fabrication processes in real time using polarized light. In some embodiments, the apparatus comprises a light source configured to generate light, a beam splitter configured to reflect the light toward the wafer being processed, an objective polarizer configured to polarize the light reflected toward the wafer and to allow light reflected by the wafer to pass therethrough, a blaze grating configured to separate light reflected by the wafer according to wavelength, an array detector configured to detect the separated light and an analyzer to analyze the three-dimensional profile of the structure/pattern being formed in the wafer.

Abstract: A rapid method for characterizing and identifying microorganisms using Focal-Plane Array (FPA)-Fourier Transform Infrared (FTIR) spectroscopy is disclosed. Multi-pixels spectral images of unknown microorganisms spectra are analyzed and compared to spectra of reference microorganisms in databases. The method allows rapid and highly reliable identification of unknown microorganisms for the purpose of medical diagnosis, food and environmental control.

Abstract: A sensor platform is provided for interrogating a sample with an electromagnetic (EM) wave. The platform includes: a dielectric material having opposing first and second planar surfaces; a first array of loop elements embedded in the first planar surface of the dielectric material, wherein slots are formed between the loop elements in the first array of loop elements and configured to host a sample material therein; and a second array of loop elements embedded in the second planar surface of the dielectric material and formed symmetrically with respect to the first array of loop elements, wherein slots are also formed between the loop elements of the second array of loop elements. The loop elements in the first array and the second array are comprised of a conductive material.

Abstract: A method of processing diffuse spectrum data may include: obtaining diffuse spectrum data of a medium to be detected at one or more first radial positions; and determining optical information caused by substantially only a variation in scattering characteristic of the medium to be detected and/or optical information caused by substantially only a variation in absorption characteristic of the medium to be detected at one or more second radial positions from the obtained diffuse spectrum data.

Abstract: Disclosed is a sample analyzer which comprises: a sample preparing section configured to prepare a measurement sample by mixing a sample and a nucleic acid staining reagent; an optical detector configured to irradiate light on cells contained in the measurement sample, receive fluorescent light given off by the irradiated cells, and output fluorescent light signals; a signal processing section which obtains fluorescent light intensity and fluorescence pulse area of the cells from the fluorescent light signals output by the optical detector; and an information processing section configured to detect white blood cells contained in the measurement sample based on the fluorescence pulse area, and detect bacteria contained in the measurement sample based on the fluorescent light intensity.

Abstract: In a STED fluorescence light microscope pulses of excitation light (3) are applied to a sample, which excite fluorescent entities contained in the sample for fluorescence, and which are focused on at least one focal area. Further, de-excitation light (12) is applied to the sample, which de-excites the excited fluorescent entities and which comprises an intensity zero point in the at least one focal area, as a continuous wave. Fluorescence light emitted by the excited fluorescent entities in the sample is registered after each pulse of the excitation light (3) and overlapping with applying the de-excitation light (13) with high temporal resolution between consecutive pulses of the excitation light (3).

Abstract: An optical apparatus comprises an ultraviolet light source (100) configured to transmit the ultraviolet light to a sample (102), one or more wavelength dependent beam splitters (104) and at least two separate detectors (106, 108). Each beam splitter (104) receives, from the sample (102), a band of excitating ultraviolet light and at least one band of fluorescence associated with an interaction between the excitating ultraviolet light and the sample (102) in the optical path through the sample (102), directs the band of excitating ultraviolet light passed through the sample (102) towards a first detector (106), and directs the at least one band of the fluorescence towards at least one separate detector (108). The first detector (106) and the at least one separate detector (108) are simultaneously configured to form electrical signals carrying information on powers of the bands of the ultraviolet light and the fluorescence, respectively.

Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.

Abstract: An assay chip includes fluidic-channel member composed of a light-transmissive lower member and an upper member, forming a fluidic-channel therebetween, and a cover member fitted with the fluidic-channel member from the upper-member-side thereof. An inlet for injecting a sample solution into the fluidic-channel and a suction opening for sucking, from the downstream side, the injected sample solution, both communicating with the fluidic-channel, are formed on the upper surface of the upper member. A pot for carrying out predetermined pre-processing on the sample solution, a pot for first-reaction processing to bind a photoresponsive labeling substance to an analyte in the sample solution, an inlet insertion-hole for inserting the inlet, and a suction-opening insertion-hole for inserting the suction opening are linearly arranged on the upper surface of the cover member.

Abstract: A surface plasmon-field enhanced fluorescence measurement device may be provided to accurately detect a specific substance even in the case in which a well member is used and achieving a simpler structure and a lower manufacturing cost, and a fluorescence detection method using the surface plasmon-field enhanced fluorescence measurement device.

Abstract: Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

Abstract: There is provided a laser scanning microscope system including a mode-locked laser unit configured to radiate a laser beam with a predetermined frequency, an intermittent light-emitting unit configured to intermittently emit the laser beam radiated from the mode-locked laser unit in a predetermined intermittent light-emission period, a detector configured to convert a fluorescent substance into an electric signal, the fluorescent substance receiving the intermittently emitted laser beam and then being excited from an object, and an A/D conversion unit configured to sample the electric signal in a sampling period synchronized with the intermittent light-emission period.

Abstract: The present invention relates to a method for detecting mitochondria alterations, which comprises the following steps: (A) providing a separation element and a sample; (B) mixing the separation element and the sample, wherein a detecting sample is obtained through the binding of a DNA fragment on the separation element to mitochondrial DNA in the sample; (C) dividing the detecting sample into a comparison group and a detection group; (D) adding an amplification solution into the comparison group and the detection group respectively to begin a DNA amplified reaction, and further adding a restriction enzyme into the detection group, wherein the amplification solution comprises a labeling reagent and a primer pair; and (E) detecting amounts of the labeling reagent in the comparison group and the detection group respectively after the DNA amplified reaction.

Abstract: Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.

Abstract: An optofluidic platform is constructed so as to comprise a planar, liquid-core integrated optical waveguides for specific detection of nucleic acids. Most preferably, the optical waveguides comprises antiresonant reflecting optical waveguide (ARROWs). A liquid solution can be prepared and introduced into the optofluidic platform for optical excitation. The resulting optical signal can be collected at the edges of the optofluidic platform and can be analyzed to determine the existence of a single and/or a specific nucleic acid.

Abstract: An apparatus and method for elemental analysis of a formation fluid from a subsurface tool having a housing, a sampling probe for collecting a sample of the formation fluid external to the housing, and a microplasma device within the housing and in fluid communication with the sampling probe. The microplasma device includes an upstream gas system, a sampling valve in fluid communication with the sampling probe and the upstream gas system, an expansion chamber for volatizing the formation fluid sample obtained from the sampling valve, and a microplasma chamber in fluid communication with the expansion chamber for ionizing the volatilized fluid sample.

Abstract: Embodiments as disclosed herein provide a method and system that characterizes physical properties, such as thickness, uniformity, polarization, and/or sizes and locations of defect (e.g. defect density distribution) of crystalline structures grown on or thin films deposited on a substrate of a solid state light emitting device. The embodiments disclosed herein generally include exciting the light emitting device with an energy source and analyze optical energy emitted by the crystalline structures grown on or the thin films deposited on the substrate.

Abstract: A defect inspection apparatus including: a first illumination optical system which is configured to illuminate the inspection area on a sample surface from a normal line direction or a direction near thereof with respect to said sample surface; a second illumination optical system which is configured to illuminate said inspection area from a slant direction with respect to said sample surface; a detection optical system having a plurality of first detectors which are located, in front of, on the sides of, and behind said inspection area, respectively, with respect to the illumination direction of said second illumination optical system, and where the regular reflected light component, from said sample surface, by illumination light of said second illumination optical system, is not converged; and a signal processing system which is configured to inspect a defect, upon basis of signals obtained from said plurality of first detectors.

Abstract: An in-line method for optically inspecting transparent or translucent containers (3) comprises illuminating each container with a light source that presents light intensity variation in a periodic pattern along at least a first variation direction. A number N greater than or equal to three of images of the container traveling in front of the light source and occupying N different respective positions along the travel path is taken. Between taking successive images, a relative shift between the container and the periodic pattern is created. A geometrical transformation is determined and applied in order to put the pixels belonging to the container in the N successive images of the same container into coincidence. A phase image for each container is constructed using the N registered images of the container. The phase image is analyzed in order to deduce therefrom at least the presence of defects or the quality of the container.

Abstract: Provided are a defect classifying method and an inspection apparatus which are capable of classifying a defect by distinguishing a basal plane dislocation, which is a killer defect in bipolar high-voltage elements, from other defects. The defect classifying method according to the present invention includes: projecting an illumination beam toward a silicon carbide substrate and forming a reflection image and a photoluminescence image; a first inspection step of detecting a defect image from the reflection image formed; a second inspection step of detecting a defect image from the photoluminescence image formed; and a defect classification step of classifying detected defects based on whether or not the defect image is detected and the shape of the detected defect image.

Abstract: A method of searching for a threat includes determining a characteristic of a target, determining an allowable dosage based on the characteristic, determining a parameter of a scanning beam based on the allowable dosage with a processing circuit, transmitting the scanning beam toward the target with a scanner, and creating a representation of the target with the processing circuit.

Abstract: An inline dark field holographic method for measuring strain in a semiconductor or other crystalline material using a transmission electron microscope having an electron gun for passing an electron beam through strained and unstrained specimens. A condenser mini-lens between the magnetic tilting coil and the specimens increases defection of the beam at an angle with prior to passing through the pair of specimens. The first objective lens forms a virtual image of each of the specimens and the second objective lens focuses the virtual images of each of the specimens at an intermediate image plane to form intermediate images of each of the specimens. The biprism creates the interference pattern between the specimens is formed at the image plane, which may then be viewed to determine the degree of strain of the strained specimen and provides a coma-free strain map with minimal optical distortion.

Abstract: A computed tomography system and an X-ray collimator thereof are provided, which have a good collimator effect. The X-ray collimator includes a plurality of first plates extending in the circumferential direction of the computed tomography system and a plurality of second plates extending in the axial direction of the computed tomography system. The first plates and the second plates are inserted and engaged. Two adjacent first plates and two adjacent second plates define a through hole, and the extensions of the side walls of the through hole intersect at the focal spot of an X-ray source, so that the X-rays can pass through the through hole in a straight line. Since the extensions of the side walls of the through holes intersect at the focal spot of the X-ray source, the through holes are aligned with the radiation direction of corresponding X-rays.

Abstract: There is provided a System and Method For Determining The Radiological Composition of Material Layers Within a Conduit. The system and method disclosed is equally applicable to pipes, vessels, and conduits as well as medical applications such as determining vessel thickness, occlusion, scarring, or the like in humans and animals. A phantom setup is disclosed that has a phantom containing a test standard such as a reactor water test standard, removable plates, a collimator and probe with a spectrometer display. The phantom setup provides a baseline data set that can be used in conjunction with field measurements to determine the composition of materials within the conduit, such as corrosion or the like. The baseline data set may be semi-logarithmic and contains spectrometer readings of various plate thicknesses or quantities of plates.

Abstract: A method includes directing an X-ray beam to be incident at a grazing angle on a location on a surface of the sample. An X-ray fluorescence excited at the location is measured. A reflection angle of the X-ray beam from the surface and a transmission angle of the X-ray beam are measured. An angle of incidence of the X-ray beam on the surface is evaluated using the measured reflection and transmission angles, and the measured X-ray fluorescence is analyzed using the evaluated angle of incidence.

Abstract: A display device includes a first substrate provided with a pixel circuit in a display region, a second substrate provided facing the first substrate, a dam agent bonding the first substrate and the second substrate and sealing the display region, and a moisture detection part provided between a first region provided with the dam agent and the display region.

Abstract: A device for measuring thermal conductivity of gas components of a gas mixture in order to determine fractions of the gas components includes a plurality of thermal conductivity sensors, each thermal conductivity sensor being a component of a resistance bridge circuit and being connected to an evaluation unit associated with the device. Each thermal conductivity sensor has a heating element and an integrated temperature measuring element, which elements generate two measuring voltages (UM3, UM2) when the temperature of the thermal conductivity sensor changes as a result of heat dissipation by the gas mixture. Voltages are compared in the evaluation unit in order to detect measuring errors.

Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked, hydrophilic copolymer sensing layer in contact with a surface of an electrode, where the sensing layer includes methacrylate-derived backbone chains having covalent bonds to an analyte sensing component. The method includes combining the precursor components of the sensing layer, depositing the combined mixture on a surface of an electrode, and curing the deposited mixture.

Abstract: The present invention relates to a device and a method for parallel recording of impedance spectra and field potential of cells in vitro.

Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.

Abstract: A controlled potential electrolysis gas sensor including, as gas electrodes 10 for detecting gas, a working electrode for electrochemically reacting gas to be detected, a counter electrode with respect to the working electrode, and a reference electrode for controlling potential of the working electrode, the gas electrodes 10 being disposed to face an electrolysis solution accommodating portion of an electrolysis tank accommodating electrolytic solution 20. Each electrode 10 includes a noble metal catalyst layer 50. On the noble metal catalyst layer 50 of at least one of the working electrode and the reference electrode, there is formed a polymer layer 60 having ion conductivity and water permeability.

Abstract: A gas sensor element which has water-permeable electrodes, and water-impermeable leads connected to the electrodes A first electrode (133) has a space exposure portion (133b) exposed to internal space (160) of a gas sensor element (10) which communicates with an ambient atmosphere. A first lead (137) is connected to the first electrode (133). The first electrode (133) includes a first connection portion (133d) which is disposed at a position not exposed to the internal space (160) and connected to the first lead (137), and which is a portion of the first electrode (133) located most distant from the internal space (160). The entire first connection portion (133d) is located in a region A1 which extends from the internal space (160) over a distance of 1.0 mm or less. Also enclosed is a gas sensor including the gas sensor element.

Abstract: The present invention relates to the field of surface water monitoring. More specifically, the present invention provides low-cost, real-time bio-electrochemical sensors for surface water monitoring based on the metabolism of one or more electrogenic microbes.

Abstract: A method and apparatus for non-invasive, real time analysis of physical and chemical properties of a medium employs electromagnetic waves induced by an excitation transducer within longitudinally magnetized strips of ferromagnetic film serving as a waveguide. A physical medium juxtaposed to the wave guide induces a charge center encountered by the pulsed electromagnetic waves. The characteristics of changes induced by the physical medium within the pulsed electromagnetic wave, such as permittivity and permeability effects, boundary oscillations and phase changes are read by detection transducers and transmitted to software for analysis of the characteristics of the physical medium.

Abstract: A device includes a sensor surface and a pair of electrodes. The sensor surface includes a first conductive layer separated from a second conductive layer by an intermediary layer, a magnetization direction of the first conductive layer and a magnetization direction of the second conductive layer having a ground state orientation of approximately 0 degrees. An electrical resistance between the pair of electrodes is determined by a magnetic field proximate the sensor surface.

Abstract: [Problem to be Solved] To provide a property measuring device for measuring a measurement object, which can highly reliably extract an electric signal serving as the measurement object from an electromagnetic field noise or the like generated by an acoustic wave generating source even if the acoustic wave is a continuous wave, while a high spatial resolution is maintained, by using an acoustic wave as a properly measuring means for measuring an object and method thereof.

Abstract: An example inspection probe device includes a sensor assembly configured to induce an eddy current in a component. A probe body houses at least a portion of the sensor assembly such that the portion of the sensor assembly is spaced from a target surface of the component when the probe body is in contact with the component. A controller is used to calculate the location of the target surface relative to the probe body using an eddy current parameter sensed by the sensor assembly.

Abstract: A phased array ultrasonic probe may be mounted to a component to be inspected for wall thickness on an apparatus that includes a split ring adapted to be magnetically held in place on the component. In particular, the probe may be mounted to a carriage connected to the split ring in a manner that allows the carriage to rotate around the split ring while the probe is in operation. Between the probe and the component, a transducer shoe defining, by a flexible membrane, a cavity and an aperture. Conveniently, the construction of the flexible membrane allows wall thickness measurements to be acquired in portions of the component that have complex topography, such as welds. The apparatus is installed on an adaptor assembly for inspection of straight section of pipes. This adaptor assembly is not used in absence of straight section.

Abstract: An L-mode guided wave sensor 10 for inspecting an inspection target by using an L-mode guided wave. The L-mode guided wave sensor 10 is provided with a vibrator 3 which is attached to an inspection target 1, and a coil 5 which is wound around the vibrator 3 and to which an AC voltage is applied. The vibrator 3 is made of a ferromagnetic material.

Abstract: A method for estimating the detonation performance of a material is executed by first preparing a small sample of the material to be tested. That sample is lased with a laser beam having sufficient energy to induce a plasma from a portion of the sample and to produce a shock wave, without detonation of the sample. The velocity of the shock wave is then measured at different times. And a characteristic shock velocity determined for the material based on the relationship between shock velocity and time. The characteristic shock velocity represents the velocity of the shock wave at the point in time when the shock front expands freely without additional energy input from the plasma or subsequent chemical reactions. The characteristic shock velocity can be used to determine whether a material is non-energetic or energetic; if it is energetic, the estimated detonation performance can be determined.

Abstract: A photoacoustic wave measurement device includes: (a) a pulsed-light outputter that outputs a pulsed light; (b) an arrangement member disposed between a pulsed-light output end of the pulsed-light outputter and a measurement object, the arrangement member being adapted to allow the pulsed light to pass therethrough; and (c) a photoacoustic wave detector that receives a photoacoustic wave generated by the measurement object by the pulsed light and that converts the photoacoustic wave into an electric signal, the photoacoustic wave measurement device being adapted to receive the electric signal from a photoacoustic wave sensor in which the photoacoustic wave detector is farther from the measurement object than the pulsed-light output end.

Abstract: A micro titer plate comprising a number of wells filled with separation matrix. According to the invention the volume of the separation matrix is varied between at least some of the wells.

Abstract: A personal-sized, portable explosive detection field test kit (ETK) and related methods of use. Embodiments of the disclosed ETK include a case having a closing system featuring three levels of closure which retain the case cover securely in a closed position until ready for use, while being easily opened when necessary. The ETK instructions are permanently attached to the case to prevent loss. The case includes retention features which retain the kit components until needed and protects them against loss or damage. The ETK includes one or more test tubes that are color coded and include abbreviated instructions.

Abstract: A method of testing the cleanability of polymerized sublimate outgassed from a lithography material during a thermal heating process including; placing a wafer on a wafer hotplate inside a chamber with the wafer being covered by a lithography material; placing a target, having a starting composition, above the wafer in the chamber; heating the wafer using the wafer hotplate in an attempt to outgas a sublimate, where the sublimate condenses on the target; forming a polymerized sublimate on the target; and applying organic solvents to the target to determine the cleanability of the polymerized sublimate.

Abstract: A method of identifying a molecule is disclosed. A molecule is drawn to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore. The molecule is released from the nanopore by applying a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore. The first period and the second period are determined based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current.

Abstract: The electronic device for sensing and/or actuating comprises a device surface to which an biological cell (40) is applied, further comprising a sensor and/or an actuator (25), and an access channel (20) with a channel port (21), said channel port being located in said surface. The access channel (20) is designed such that the biological cell (40) can enter the access channel (20) to thereby provide access to the sensor (25). Particularly the cell (40) forms a protruding portion (41) by entering the access channel (20), which portion is sensed. The access channel (20) may be provided with a specific sensor port at which the sensor (25) is present. The device may be used for sensing or actuating biological cells, such as neurons, for instance in electroporation treatments.

Abstract: In some examples, a device applies an electrical potential difference across a blood sample. The device measures an electrical signal that passes through the blood sample over a duration of time to obtain a plurality of measurements representing a measurement function of time. An accumulative property of the measurement function may be determined such that the accumulative property correlates to a blood coagulation characteristic.

Abstract: The present invention discloses a novel device and methods thereof with utility application in the high-throughput detection, screening and disease management of cervical disease. The “multiwell” device of the present invention consists of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of patient samples. The methods of the present invention comprise conventional cytological staining, cervical Pap staining, and immunochemical staining using antibodies or combination of antibodies which are capable of binding to biomarkers that are overexpressed in cancer including in cervical carcinoma and dysplasia, as compared to normal controls. The device and methods of the present invention can be practiced in either manual or automated mode, and applied to any biological fluid or cell suspension from any biological specimen in view of a variety of cell biology assays, and in view of detection and screening of cervical and other diseases.