Patents Issued in February 7, 2017
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Patent number: 9561277Abstract: An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation. Also, the aqueous liquid preparation of the present invention in the form of a nasal drop is useful for the treatment of allergic rhinitis and inflammatory rhinitis (e.g. chronic rhinitis, hypertrophic rhinitis, nasal polyp, etc.).Type: GrantFiled: September 30, 2014Date of Patent: February 7, 2017Assignee: SENJU PHARMACEUTICAL CO., LTD.Inventors: Shirou Sawa, Shuhei Fujita
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Patent number: 9561278Abstract: Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.Type: GrantFiled: September 28, 2015Date of Patent: February 7, 2017Assignees: The University of British Columbia, Centre for Drug Research and DevelopmentInventors: Helen M. Burt, Donald E. Brooks, Jayachandran N. Kizhakkedathu, Richard Liggins, Dechi Guan, Lu Ye, Clement Mugabe, Alan So, Martin E. Gleave, John K. Jackson, Rajesh Kumar Kainthan
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Patent number: 9561279Abstract: There is provided a pharmaceutical composition for the treatment of fungal infection of the nail comprising a antifungal allylamine compound present in an amount of about 10%, an organic acid or an ester thereof, a diol and a sequestering agent where the pharmacological composition is essentially water-free.Type: GrantFiled: November 6, 2014Date of Patent: February 7, 2017Assignee: Moberg Pharma ABInventor: Ake Lindahl
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Patent number: 9561280Abstract: An aqueous liquid bromfenac composition containing (a) bromfenac or a salt thereof and (b) benzalkonium chloride, characterized by that the composition has preservative efficacy and that the concentration of (b) benzalkonium chloride is higher than 0.0005% and lower than 0.005%.Type: GrantFiled: July 8, 2015Date of Patent: February 7, 2017Assignee: SENJU PHARMACEUTICAL CO., LTD.Inventors: Shuichi Nishihata, Wakiko Asayama, Suzuka Iemoto
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Patent number: 9561281Abstract: Provided herein are compositions for applying a reference marker pattern or grid to the surface of an object to be imaged three-dimensionally. These compositions can be quick drying for ease of use. Methods of use of the compositions are also provided as well as devices and kits for the application of the compositions.Type: GrantFiled: March 4, 2015Date of Patent: February 7, 2017Assignee: ARGES IMAGING, INC.Inventors: Jian Lu, David Licata
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Patent number: 9561282Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.Type: GrantFiled: October 27, 2015Date of Patent: February 7, 2017Assignee: Tolmar Therapeutics, Inc.Inventors: Eric Dadey, John Middleton, Richard L. Norton
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Patent number: 9561283Abstract: The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.Type: GrantFiled: September 30, 2015Date of Patent: February 7, 2017Assignee: ENZYMOTEC LTD.Inventors: Gai Ben Dror, Dorit Platt, Orly Farkash, Rassan Zuabi, Zohar Bar-On, Avidor Shulman, Dori Pelled, Yael Richter
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Patent number: 9561284Abstract: A pharmaceutical composition includes a block copolymer having a hydrophilic segment, a hydrophobic segment, and a boronic acid compound bound to a side chain of the hydrophobic segment via a linker moiety that includes a heterocyclic structure. The heterocyclic structure contains a cyclic skeleton that includes a boron atom of the boronic acid compound, one or two atom(s) X bound to the boron atom and selected from an oxygen atom and a nitrogen atom, and one or two carbon atom(s) (respectively) bound to the atom(s) X. The block copolymer further includes at least one organic group bound to the carbon atom(s). The organic group(s) contain(s) an aromatic group or cyclic alkyl group that sterically protects a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atom(s) X.Type: GrantFiled: April 2, 2012Date of Patent: February 7, 2017Assignee: NANOCARRIER CO., LTD.Inventors: Hiroyuki Saito, Katsutoshi Kobayashi, Ryosuke Tanaka, Mitsunori Harada, Yasuki Kato
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Patent number: 9561285Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.Type: GrantFiled: January 21, 2011Date of Patent: February 7, 2017Assignee: Ascendis Pharma ASInventors: Harald Rau, Torben Lessmann
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Patent number: 9561286Abstract: A compound composed of a phospholipid and basic amino acid residues is provided as is a sterically stabilized phospholipid nanocarrier containing the compound and use of the same in passive and targeted delivery of negatively charged therapeutic agents encapsulated within the nanocarrier.Type: GrantFiled: March 4, 2016Date of Patent: February 7, 2017Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Hayat Onyuksel, Fatima A. Khaja
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Patent number: 9561287Abstract: The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).Type: GrantFiled: August 10, 2012Date of Patent: February 7, 2017Assignee: Ascendis Pharma A/SInventors: Ulrich Hersel, Harald Rau, Torben Lessmann, Nicola Bisek, Guillaume Maitro, Kennett Sprogøe, Thomas Wegge, Oliver Keil, Joachim Zettler
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Patent number: 9561288Abstract: The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-VEGF antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.Type: GrantFiled: February 27, 2013Date of Patent: February 7, 2017Assignee: ABRAXIS BIOSCIENCE, LLCInventors: Neil P. Desai, Patrick Soon-Shiong
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Patent number: 9561289Abstract: A product comprising a peptide that comprises a motif selected from a group consisting of isoDGR, NGR and DGR, wherein the peptide cyclized by joining the N- and C-termini of its main chain and wherein the cyclic peptide is joined to albumin.Type: GrantFiled: March 14, 2013Date of Patent: February 7, 2017Assignee: OSPEDALE SAN RAFFAELE SRLInventors: Angelo Corti, Flavio Curnis
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Patent number: 9561290Abstract: The invention relates to new functionalized thieno-indole derivatives of formula (I) or (II) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular proliferation disorders. The invention also relates to the use of these functionalized thieno-indole derivatives in the preparation of conjugates.Type: GrantFiled: March 28, 2013Date of Patent: February 7, 2017Assignee: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Italo Beria, Michele Caruso, Vittoria Lupi, Paolo Orsini, Matteo Salsa
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Patent number: 9561291Abstract: The invention provides a method of targeting T-cells to tumor cells using a tumor-associated antigen (TAA) specific antibody and a T-cell specific antibody, wherein the two antibodies can bind to each other through a high affinity avidin/biotin or streptavidin/biotin connection. The invention further provides methods to target activated T-cells to different tumor types by using a T-cell specific antibody that is specific to an activated T-cell surface molecule like CTLA-4.Type: GrantFiled: March 15, 2013Date of Patent: February 7, 2017Inventors: Imre Kovesdi, Tibor Bakács, Miklós Szabó
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Patent number: 9561292Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.Type: GrantFiled: August 20, 2013Date of Patent: February 7, 2017Assignee: Duke UniversityInventors: Tuan Vo-Dinh, Hsiangkuo Yuan, Andrew Fales, Christopher Khoury
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Patent number: 9561293Abstract: This disclosure relates to a method for preparing organic microbubble complex particles including sonicating an aqueous solution including a graphene compound and an amphiphilic material in the presence of a gas, a method for preparing organic microbubble complex particles including injecting an aqueous solution including a graphene compound and an amphiphilic material into a microchannel, and an organic microbubble complex particle including a core part including at least one gas selected from the group consisting of an inert gas and carbon dioxide, and a shell layer including a graphene compound and an amphiphilic material, and an ultrasound contrast agent including the organic microbubble complex particles.Type: GrantFiled: March 7, 2014Date of Patent: February 7, 2017Assignee: SNU R&DB FOUNDATIONInventors: Kookheon Char, Saibom Park
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Patent number: 9561294Abstract: A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least one of the elements includes antimicrobial metal, which, when energized by the power source, produces ions that are lethal to microbes. The device can be incorporated into virtually any useful object. During normal use of the object, electrical communication is established between the two elements, causing current supplied from the power source to flow through the antimicrobial metal. The two elements are configured and arranged to ensure that ions flowing from the antimicrobial metal flow through the region in which it is desired to kill microbes. The antimicrobial metal can be on the surface of the element, incorporated into the material making up the element, or provided in any other way that allows the antimicrobial effect to be achieved.Type: GrantFiled: November 26, 2013Date of Patent: February 7, 2017Assignee: ARGENTUMCIDAL ELECTRICS, INC.Inventors: Thomas A. Fuller, Richard Wysk, Wayne J. Sebastianelli, Paul H. Cohen, Robert C. Voigt
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Patent number: 9561295Abstract: A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least one of the elements includes antimicrobial metal, which, when energized by the power source, produces ions that are lethal to microbes. The device can be incorporated into virtually any useful object. During normal use of the object, electrical communication is established between the two elements, causing current supplied from the power source to flow through the antimicrobial metal. The two elements are configured and arranged to ensure that ions flowing from the antimicrobial metal flow through the region in which it is desired to kill microbes. The antimicrobial metal can be on the surface of the element, incorporated into the material making up the element, or provided in any other way that allows the antimicrobial effect to be achieved.Type: GrantFiled: December 11, 2013Date of Patent: February 7, 2017Assignee: ARGENTUMCIDAL ELECTRICS, INC.Inventors: Thomas A. Fuller, Richard Wysk, Wayne J. Sebastianelli, Paul H. Cohen, Robert C. Voigt
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Patent number: 9561296Abstract: A disinfecting apparatus for cleaning, disinfecting, and sanitizing restraining devices used by law enforcement and correctional facilities is designed to allow the disinfectant solution to evaporate that comprises a compartment that includes an interior chamber and a door, a disinfectant chamber for retaining the disinfectant solution, a plurality of jets, at least one plenum, an air compressor for conveying the disinfectant solution from the disinfectant chamber to the compartment through the plurality of jets, a power switch, and an electrical power plug to electrically connect the disinfecting apparatus to a power supply. The rear wall of the compartment includes a plurality of support structures to support a plurality of restraining devices within the interior chamber. The outer side of the rear wall of the compartment includes a mounting system that secures the disinfecting apparatus to a vertical, planar surface.Type: GrantFiled: August 11, 2015Date of Patent: February 7, 2017Inventor: Shawki Sobhy
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Patent number: 9561297Abstract: The invention relates to a fractional vacuum sterilization method for objects such as blood tubing systems or cassette systems, which are sterilized in outer packagings. The spatial extent of the outer packaging during the evacuation step is minimized here by inserting a packing into the sterilization chamber and thereby achieving an efficient gas exchange through the gas-permeable outer packaging. The number of vacuum-pressure cycles required to establish a saturated sterilization medium atmosphere in the outer packaging and in the object to be sterilized is thereby reduced.Type: GrantFiled: October 1, 2013Date of Patent: February 7, 2017Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventor: Stefan Kreber
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Patent number: 9561298Abstract: A contoured sterilizing element is configured to conform to the outer and inner surfaces of a working end-site of a medical device such as a catheter hub, luer connector, luer component, needleless access site, and/or access port. The sterilizing element is made from absorbent material and can be pre-moistened or impregnated with an anti-pathogenic agent. The sterilizing element can be contained within a housing that is easily gripped and opened in one hand by the user. The sterilizing element is configured to wipe debris from and to sterilize and/or dry a working end-site of medical device, using a wiping, twisting, dabbing, push/pull, and/or screwing motion around all of the surface aspects of the device to be sterilized.Type: GrantFiled: August 22, 2012Date of Patent: February 7, 2017Inventors: Michael J. Ferlic, Mason J. Ferlic, Nicholas R. Powley
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Patent number: 9561299Abstract: An absorbent article includes a chassis comprising a topsheet, a backsheet, and an absorbent core disposed between the topsheet and the backsheet, and at least one elastically elongatable panel joined to the chassis. The elastically elongatable panel includes a stretch laminate that has at least one cover layer and an elastomeric film attached to the cover layer, the elastomeric film having two surfaces and a skin on at least one of the surfaces. The stretch laminate has at least one anchoring zone and at least one stretch zone and the skin that is located in the anchoring zone has a plurality of activation stripes.Type: GrantFiled: April 30, 2014Date of Patent: February 7, 2017Assignee: The Procter & Gamble CompanyInventors: Marcus Schonbeck, Henner Sollmann, Georg Baldauf, Urmish Popatlal Dalal, Miguel Alberto Herrera, Erica Lynne Locke
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Patent number: 9561300Abstract: The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita), the leaves of dioecious nettle (Urtica dioica), kaolin, chitosan, fibrinogen and thrombin. Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with superior and broad spectrum hemostatic capabilities, including the ability to arrest arterial hemorrhage. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile, nettle, kaolin, chitosan, fibrinogen and thrombin components is applied to a textile or fabric material, for example a non-woven viscose.Type: GrantFiled: September 14, 2012Date of Patent: February 7, 2017Assignees: YES, INC., THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Linda Eastwood, Harold Coons, James M. Sinclair, Matthew D. Bacchetta, Gopal Singh
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Patent number: 9561301Abstract: One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.Type: GrantFiled: April 14, 2015Date of Patent: February 7, 2017Assignee: Aeris Therapeutics, LLCInventors: Edward P. Ingenito, James A. Krom, Alexander Schwarz, Larry W. Tsai
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Patent number: 9561302Abstract: A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 mm Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.Type: GrantFiled: September 14, 2012Date of Patent: February 7, 2017Assignee: Benz Research & Development Corp.Inventors: Patrick H. Benz, Adam Reboul
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Patent number: 9561303Abstract: A biocompatible composition for tissue repair or regeneration in mammals comprising one or more glass former compounds selected from the group consisting of B2O3, P2O5, and SiO2 and director elements selected from the group consisting of Cu, Sr, Zn, Fe, Mn, Cr, V, Nb, Mo, W, Ba, Co, S, Al, Ti, Y, Mg, Si and/or Ni to promote in vivo calcium compound formation of calcium carbonate or other calcium compounds other than hydroxyapatite. Upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium compounds other than hydroxyapatite form upon bioreaction of the composition with bodily fluids.Type: GrantFiled: July 6, 2012Date of Patent: February 7, 2017Assignee: The Curators of the University of MissouriInventors: Steven B. Jung, Delbert E. Day
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Patent number: 9561304Abstract: The invention relates to a biomaterial containing coagulated blood or coagulated bone marrow aspirate and biphasic calcium phosphate ceramic particles, to a production method thereof and to the use of same for the production of an implant that enables bone tissue regeneration.Type: GrantFiled: June 22, 2009Date of Patent: February 7, 2017Assignees: Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire De NiceInventors: Thierry Balaguer, Nathalie Rochet, Christophe Trojani, Florian Boukhechba, Georges Carle
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Patent number: 9561305Abstract: The invention relates to a hydroxylapatite material, for the production of which a nanoscale hydroxylapatite paste is subjected to a thermal treatment.Type: GrantFiled: September 2, 2010Date of Patent: February 7, 2017Assignee: AAP BIOMATERIALS GMBHInventors: Elvira Dingeldein, Lydia Heimann, Georgiana Gasqueres, Marco Wolfstadter
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Patent number: 9561306Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: GrantFiled: March 10, 2014Date of Patent: February 7, 2017Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 9561307Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.Type: GrantFiled: May 14, 2015Date of Patent: February 7, 2017Assignee: ACell, Inc.Inventors: Rodney W. Bosley, Jr., Clay Fette, Robert S. Tullius
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Patent number: 9561308Abstract: A bimetal composite wire including, in cross-section, an outer shell or tube formed of a first biodegradable material and an inner core formed of a second biodegradable material. When formed into a stent, for example, the first and second biodegradable materials may be different, and may have differing biodegradation rates. In a first embodiment, the first biodegradable material of the shell may degrade relatively slowly for retention of the mechanical integrity of a stent during vessel remodeling, and the second biodegradable material of the core may degrade relatively quickly. In a second embodiment, the first biodegradable material of the shell may degrade relatively quickly, leaving a thinner structure of a second biodegradable material of the core that may degrade relatively slowly.Type: GrantFiled: June 24, 2011Date of Patent: February 7, 2017Assignee: Fort Wayne Metal Research Products CorporationInventor: Jeremy E. Schaffer
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Patent number: 9561309Abstract: A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: GrantFiled: May 27, 2004Date of Patent: February 7, 2017Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Eugene Michal, Charles Claude, Stephen D. Pacetti
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Patent number: 9561310Abstract: The present invention includes biocompatible polymeric coatings, membranes, matrices, and films to be used with implantable medical devices. Medical devices containing such materials applied to a surface thereof contain a film-forming fluorous homo-polymer or copolymer containing the polymerized residue of a fluorous moiety, wherein the relative amounts of the polymerized residues of one or more moieties are effective to provide the coating and films with properties effective for use in coating implantable med devices.Type: GrantFiled: October 27, 2014Date of Patent: February 7, 2017Assignee: Cardinal Health Switzerland 515 GmbHInventor: Jonathon Z. Zhao
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Patent number: 9561311Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.Type: GrantFiled: May 18, 2015Date of Patent: February 7, 2017Assignee: CoDA Therapeutics, Inc.Inventors: David Lawrence Becker, Colin Richard Green, Bradford James Duft
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Patent number: 9561312Abstract: A manually-activated reduced pressure treatment system includes a substantially rigid housing, and an end cap slidingly received by the housing. An inner chamber is disposed between the end cap and housing, and a volume of the inner chamber is variable in amount depending on the position of the end cap within the housing. The end cap is slidingly movable between an uncompressed position at which the volume of the inner chamber is at a maximum value and a compressed position at which the volume of the inner chamber is at a minimum value. A position indicating member is associated with the end cap and housing to indicate the position of the end cap relative to the housing at predetermined positions between the uncompressed position and the compressed position.Type: GrantFiled: February 4, 2014Date of Patent: February 7, 2017Assignee: KCI Licensing, Inc.Inventors: Keith P. Heaton, Ian James Hardman
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Patent number: 9561313Abstract: A rotor for an axial-flow blood pump has blades projecting outwardly from a hub and channels between the blades. The blades incorporate hydrodynamic bearing surfaces capable of suspending the rotor during operation. The rotor has a configuration which provides superior pumping action and reduced shear of blood passing through the pump. The forwardly facing pressure surfaces of the blades may include outflow corner surface at their downstream ends. The outflow corner surfaces desirably slope rearwardly and intersect the rearwardly-facing suction surfaces of the blades at outflow ends of the blades.Type: GrantFiled: August 14, 2014Date of Patent: February 7, 2017Assignee: HeartWare, Inc.Inventor: Mustafa Ertan Taskin
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Patent number: 9561314Abstract: An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.Type: GrantFiled: August 17, 2016Date of Patent: February 7, 2017Assignee: MAQUET CARDIOVASCULAR LLCInventors: Walid N. Aboul-Hosn, William R. Kanz, Bruce A. Baker
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Patent number: 9561315Abstract: A miniaturized cardiopulmonary bypass circuit for a mouse comprises at least one venous catheter connected to a patient, a dual channel peristaltic pump having one channel to move the blood by tubing from the patient, an oxygenator that removes gases from the blood and mixes the blood with fresh gases to oxygenate the blood, the blood being moved from the oxygenator to the arterial catheter by the dual channel peristaltic pump, and an arterial catheter. The blood is pumped by a two-channel roller pump into an inlet nozzle, where the flow of blood is transformed from tubular flow to planar flow. Gas exchange occurs inside the case while the blood flows down the central component. Blood then flows down the central component into the arterial reservoir. The arterial reservoir is connected to the second channel of the pump, and returned to the patient through a cannula.Type: GrantFiled: February 19, 2014Date of Patent: February 7, 2017Inventors: Jay Vincelli, David McClatchy, Stephanie Wolf, Ryan J. Halter
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Patent number: 9561316Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.Type: GrantFiled: March 20, 2012Date of Patent: February 7, 2017Assignee: Medtronic, Inc.Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
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Patent number: 9561317Abstract: A method for delivering a target volume of fluid to a destination is provided. The method includes delivering a first volume of fluid to the destination in increments each having approximately a first incremental volume, the first volume of fluid being less than the target volume and delivering a second volume of fluid to the destination in increments each having approximately a second incremental volume, the second incremental volume being less than the first incremental volume, such that the sum of the first volume and the second volume is approximately equal to the target volume.Type: GrantFiled: June 5, 2014Date of Patent: February 7, 2017Assignee: DEKA Products Limited PartnershipInventors: Carl R. Distler, Gregory L. Distler, Jason A. Demers, Geoffrey P. Spencer, Robert J. Bryant, Jr.
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Patent number: 9561318Abstract: A method for delivering a target volume of fluid to a destination is provided. The method includes delivering a first volume of fluid to the destination in increments each having approximately a first incremental volume, the first volume of fluid being less than the target volume and delivering a second volume of fluid to the destination in increments each having approximately a second incremental volume, the second incremental volume being less than the first incremental volume, such that the sum of the first volume and the second volume is approximately equal to the target volume.Type: GrantFiled: June 5, 2014Date of Patent: February 7, 2017Assignee: DEKA Products Limited PartnershipInventors: Carl R. Distler, Gregory L. Distler, Jason A. Demers, Geoffrey P. Spencer, Robert J. Bryant, Jr.
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Patent number: 9561319Abstract: A device for fixing a segment of tubing in the form of a loop, for an apparatus by which a fluid is fed to or out from a patient via tubing, in particular for monitoring vascular access in extra-corporeal blood treatment, and a tubing and an arrangement for monitoring, each having the device for fixing the segment, are also described. The fixing of the segment includes a guiding piece and a securing piece. The guiding piece fixes intersecting portions of the segment which forms an eye, thereby forming a loop which contracts under a tractive stress. The securing piece fixes a portion of the segment forming the eye such that when the loop tightens, that portion of the segment does not slip through the guiding piece. Alternatively, intersecting portions of the segment are fixed in a loop only by a guiding piece formed as an annular body.Type: GrantFiled: August 3, 2012Date of Patent: February 7, 2017Assignee: Fresenius Medical Care Deutschland GmbHInventor: Alexander Bongers
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Patent number: 9561320Abstract: A device for promoting patency of a fistula includes an annular body and a plurality of vanes formed integrally with the annular body, and projecting inwardly from an inner radial surface thereof. The vanes are oriented so as to impart circumferential velocity components to blood passed through a lumen of the device, and such that an unobstructed line of sight parallel to a central axis of the annular body extends between adjacent ones of the vanes.Type: GrantFiled: March 25, 2015Date of Patent: February 7, 2017Assignee: Cook Medical Technologies LLCInventors: Adam Shields, Keith Milner
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Patent number: 9561321Abstract: Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.Type: GrantFiled: November 27, 2012Date of Patent: February 7, 2017Assignee: Alcon Research, Ltd.Inventors: Gary P. Sorensen, Michael D. Morgan, Mel Matthew Oliveira
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Patent number: 9561322Abstract: An integrated pump module is disclosed that includes a rigid housing having a fluid outlet, a fluid reservoir within the housing, and a pumping segment coupled between the fluid reservoir and the fluid outlet. The pumping segment is configured to cause fluid to flow from the fluid reservoir to the fluid outlet.Type: GrantFiled: January 6, 2011Date of Patent: February 7, 2017Assignee: CAREFUSION 303, INC.Inventors: Erik Barnes, Robert D. Butterfield
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Patent number: 9561323Abstract: A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.Type: GrantFiled: March 14, 2013Date of Patent: February 7, 2017Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Kulwinder S. Plahey, Jie Zhu, Tri Ly, Robert Matthew Ohline, William Scott Crawford
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Patent number: 9561324Abstract: Some embodiments of an infusion pump system may be configured to wirelessly communicate with other devices using near field communication (NFC). In particular embodiments, by incorporating near field communication capabilities into the infusion pump system, user communications with the infusion pump system can be enhanced and simplified.Type: GrantFiled: July 19, 2013Date of Patent: February 7, 2017Assignee: Bigfoot Biomedical, Inc.Inventor: Mark C. Estes
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Patent number: 9561325Abstract: An indwelling assembly includes an inner needle having a sharp needlepoint at a distal end to puncture a blood vessel of a patient, an inner needle hub fixed to the proximal portion of the inner needle, a hollow elongated outer member in which the inner needle is positioned, with the hollow elongated member being movable in a distal direction relative to the inner needle after puncturing the patient's blood vessel, an outer member hub fixed to the proximal portion of the hollow elongated outer member, an elongated contact member configured to contact an intermediate portion of the hollow elongated outer member, and an elongated movable member movable relative to the hollow elongated outer member and the outer member hub. The elongated movable member is connected to the inner needle hub so that the inner needle hub, the inner needle and the elongated movable member move together.Type: GrantFiled: October 7, 2015Date of Patent: February 7, 2017Assignee: TERUMO KABUSHIKI KAISHAInventor: Masahiro Ishida
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Patent number: 9561326Abstract: A coupling device for transferring substances, in particular medical substances, is disclosed. The coupling device can be used for transferring medical substances between a patient and an infusion bag containing the medical substances. In one or more embodiments, the coupling device may include a piercing member for connection to a medical device such as the infusion bag. A piercing member for a coupling device is also disclosed.Type: GrantFiled: February 7, 2012Date of Patent: February 7, 2017Assignee: Carmel Pharma ABInventors: Alexander Cederschiöld, Tobias Rosenquist