Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-1R, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

Abstract: The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to a Target, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.

Abstract: Provided herein are methods of treating prostate cancer in particular androgen receptor inhibitor nave prostate cancer using anti-STEAP-1 antibodies and immunoconjugates thereof.

Abstract: A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.

Abstract: Disclosed are AAV viral-based vector compositions useful in delivering a variety of nucleic acid segments, including those encoding therapeutic polypeptides to selected mammalian host cells for use in therapeutic autoimmune modalities, including, for example, the in vivo induction of immunological tolerance via a liver-directed AAV-based gene therapeutic regimen for treating and/or ameliorating autoimmune disorders such as multiple sclerosis.

Abstract: This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.

Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

Abstract: The problem is to provide a method that can quickly and efficiently evaluate the toxicity of human cerebrospinal fluid (CSF) with small amounts of human CSF. The problem is solved by a method comprising administering human CSF into the cerebral ventricle of a rodent such as a mouse, and evaluating the cognitive function of the rodent by using a behavioral pharmacological technique.

Abstract: An aptamer-mRNA conjugate is provided. The aptamer-mRNA conjugate may include an aptamer component that binds a membrane associated protein on a target cell and an mRNA component that is expressed by the target cell.

Abstract: Imaging systems and methods are provided. Systems and methods of the subject invention can include the use of nanoparticles (for example, nanophosphors) within a sample to be imaged. Excitation with radiation, such X-ray radiation, can be performed on the nanoparticles to give rise to a change in one or more resonance parameters of the nanoparticles, and this change can be measured using magnetic resonance imaging to provide localization information.

Abstract: A method for high temperature sterilization of an emulsion, in particular a dermocosmetic preparation. The method includes the steps of gradually pre-heating, performing ultra-high temperature sterilization and gradually cooling the emulsion. The emulsion is heated up to a pre-heating temperature, which is the temperature of the emulsion at the stability limit. Ultra-high temperature sterilization is performed by infusion of the pre-heated emulsion by heating the emulsion up to a sterilization temperature, maintaining the emulsion at the sterilization temperature, and cooling the emulsion under a vacuum at an end-of-sterilization temperature. The emulsion is gradually cooled with agitation to a storage temperature.

Abstract: A system and apparatus for sanitizing devices with complex shapes. The system is comprised essentially of a mechanism for emitting sanitizing electromagnetic radiation within an enclosed compartment. The apparatus may be light-tight such that the radiation is contained within the apparatus. It may be configured to emit a plurality of sanitizing wavelengths. The apparatus may also be sound-tight, limiting or preventing the transmission of acoustic sounds made by the devices being sanitized. The apparatus may include a series of reflective and refractive apparatuses to alter the reflection path of the emitted electromagnetic radiation, allowing the apparatus to be used for devices with complex shapes. The enclosure may include support devices, such as dividers and support plates, that may be transparent to the electromagnetic radiation. The apparatus may include a locking mechanism. The system may include a control module including a user interface.

Abstract: A disinfecting apparatus for cleaning, disinfecting, and sanitizing restraining devices used by law enforcement and correctional facilities is designed to allow the disinfectant solution to evaporate that comprises a compartment that includes an interior chamber and a door, a disinfectant chamber for retaining the disinfectant solution, a plurality of jets, at least one plenum, an air compressor for conveying the disinfectant solution from the disinfectant chamber to the compartment through the plurality of jets, a power switch, and an electrical power plug to electrically connect the disinfecting apparatus to a power supply. The rear wall of the compartment includes a plurality of support structures to support a plurality of restraining devices within the interior chamber. The outer side of the rear wall of the compartment includes a mounting system that secures the disinfecting apparatus to a vertical, planar surface.

Abstract: To provide a PTP blister sheet exhibiting a high adsorption effect over prolonged periods, and a PTP blister pack formed from it. A PTP blister sheet having at least a gas barrier layer and an odor adsorption layer, wherein the odor adsorption layer comprises a heat-sealable resin containing an odor adsorption agent, and the odor adsorption agent is formed by a chemical adsorption agent supported on an inorganic porous body, and a PTP blister pack formed from it.

Abstract: An air freshener assembly for releasing a chemical scent into an area includes a vent that may be positioned within an air duct. A filter is removably coupled to the vent. The filter is infused with a chemical scent such that the filter may release the chemical scent into the air urged by the air duct.

Abstract: The invention relates to a volatile composition dispenser. The volatile composition dispenser comprises a sealed reservoir containing a volatile composition, a membrane surrounding at least part of the sealed reservoir, and a rupture mechanism formed of a single piece of plastic located between the membrane and the sealed reservoir. The rupture mechanism comprises a support, and a movable portion attached to the support at a proximal end of the movable portion by at least one connection member. The connection member has a depth less than the depth of the movable portion and/or a width less than the width of the movable portion. One or more rupture elements are located at a distal end of the movable portion, wherein the distal end of the movable portion is movable relative to the support upon activation. Upon activation of the rupture mechanism, the one or more rupture elements are moved into contact with the reservoir such that they puncture the reservoir to release the volatile composition.

Abstract: An air conditioning device including an indoor unit and an outdoor unit. The indoor unit includes an air guide grid and an electron emitting assembly, and the electron emission assembly includes an electron emitter.

Abstract: A system for applying a novel odor abating solution to an odor-emitting surface includes a storage compartment comprising a solution of iodine having a concentration of at least 0.0005% by total weight of the solution of I2; a misting system having mist nozzles that are supported over the odor-emitting surface, creating an aerial environment between the odor-emitting surface and the mist nozzles; misting nozzles configured to spray droplets of the solution into the aerial environment over the odor-emitting surface so that, in absence of any air movement exceeding 1 kilometer/hour, at least 75% of the droplets are suspended in the aerial environment over the odor-emitting surface for at least 10 seconds, allowing at least 1% by weight of the I2 in the solution to react with emitted odor before the 75% of the droplets are deposited on the odor-emitting surface. The odor-emitting surface may be within a waste transfer station.

Abstract: Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

Abstract: The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.

Abstract: A method of forming a scaffold is disclosed herein. In some embodiments, a method of forming a scaffold includes dissolving a polymer in a solvent to form a polymer solution; adding additive precipitating agent to the polymer solution; precipitating and expanding the polymer from the polymer solution to form a scaffold; and removing the solvent from the scaffold. In some embodiments, prior to adding the precipitating agent, the method further comprising adding at least one of calcium phosphate or a bioactive additive to the polymer solution to form a mixture including the polymer solution and the at least one of calcium phosphate or bioactive additive.

Abstract: A heparan sulphate that binds TGP?1 is disclosed.

Abstract: Preparations containing hepatocyte growth factor (HGF) and hyaluronic acid (HA) and methods of making and using same. The HGF and HA preparations can be prepared together in solution as an injectable fluid without gelatinization, or impregnated within a porous hydrophilic matrix material with, or without, cross-linking of the HA with the matrix material. The preparations can be used as a dermal filler or to generate and promote healing of cartilage, vertebral discs, connective tissues such as tendons and ligaments and bone in vivo.

Abstract: Various embodiments of surface-modified devices, components, and associated methods of manufacturing are described herein. In one embodiment, an implantable device suitable for being implanted in a patient includes an implantable material having a utile shape and a surface and a modification material deposited on at least a portion of the surface of the implantable material. The modification material has a release rate in an implantation environment in the patient.

Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction, The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.

Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.

Abstract: A catheter may include a hypotube defining an inner circumferential surface, an outer circumferential surface, and an end. The hypotube may include a metal or alloy. The catheter also may include an inner liner attached to the inner circumferential surface of the hypotube and extending beyond the end of the hypotube, and the inner liner may include a fluoropolymer. The catheter further may include a hub and a single bonding layer attached to the outer circumferential surface of the hypotube and bonded to the hub. The single bonding layer may include a polyamide, a polyether-co-polyamide, or polyurethane and is the only layer between the outer circumferential surface of the hypotube and the hub.

Abstract: The invention provides lubricating compositions and methods of use thereof in man or in animals. Specifically, provided are lubricating compositions comprising effective amounts of chondroitin sulfate and hyaluronan, and optionally include N-acetyl D-glucosamine.

Abstract: A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.

Abstract: The invention provides medical devices comprising improved non-uniform coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: A manifold for use with a surgical waste collection unit. The manifold includes a housing dimensioned to seat in a receiver of the waste collection unit with a fitting for receiving a suction tube. The housing has an outlet opening through which a suction is drawn so as to draw waste through the suction line, the fitting and the housing into the waste collection unit. Two tabs extends radially outwardly from the housing. The tabs are dimensioned to engage complementary slots in the receiver so as to facilitate the rotation alignment of the manifold in the receiver. In many versions of the invention, the tabs subtend different arcuate lengths. A filter is disposed in the housing to filter material that, as a consequence of the suction being drawn on the housing, is drawn through the housing.

Abstract: A suction device (1) having a suction port (90) exposed outside, a flow passage (91 to 98) communicating with the suction port (90), and a discharge port (99) through which fluid is discharged from the flow passage (91 to 98) includes a diaphragm (83) having one principal surface facing a pump chamber (98) and the other principal surface opposed to the one principal surface, and a piezoelectric element (81) attached to the diaphragm (83) to displace the one principal surface of the diaphragm (83) relative to the pump chamber (98). The one principal surface and the other principal surface of the diaphragm (83) face in a direction different from a direction to which the suction port (90) faces.

Abstract: A system for removing material from the body of a patient, the system including a aspiration catheter insertable into the patient having a distal end with a steerable tip configured to bend in one or more directions and a controller mechanically coupled to the aspiration catheter and operable by a user to bend the steerable tip in the one or more directions. The system may also include a pump having an inlet port in fluid communication with the aspiration catheter and a discharge port in fluid communication with a return catheter configured to be inserted into the patient to return aspirated blood to the patient. A filter device may be positioned between the aspiration catheter and the pump, the filter device configured to trap solid material received in the aspiration catheter from the body of the patient.

Abstract: A wound care device having a covering device fixable to the skin surrounding a wound and used for producing a closed wound space containing the wound. At least sections of the covering device are water vapor-permeable. The covering device preferably comprises a tubular film and a suction port across which a negative pressure can be generated in the wound space. The tubular film preferably has an opening with an opening length of at least 80 cm and more preferably of at least 130 cm.

Abstract: A surgical waste collection unit with a receiver for removably holding a manifold to which suction lines are connected. The receiver is mounted to the waste collection unit to be at an acute angle relative to the horizontal. The receiver is further configured to allow the manifold to be rotated in the receiver. This means the manifold can be rotated from a first position in which the manifold outlet opening is aligned with the conduit through which waste is flowed from the receiver and a second position in which the manifold outlet opening is elevated relative to the first position.

Abstract: Negative pressure wound therapy systems are described that can prevent the retainment of wound fill material in a wound cavity during dressing changes. The negative pressure wound therapy system includes a removal device that can be used to lift the wound fill material out of a wound cavity and prevent fracture of the wound fill material and retainment of fragments of the material in the wound. The removal device can include fibers (e.g., a fibrous net) that can be retained between the wall of the wound cavity and the wound fill material, with the wall of the wound and the wound fill material retaining direct contact with one another to encourage healing of the wound according to the therapy treatment process.

Abstract: A system suitable for treating a tissue site may include an interface manifold, an interface sealing member, an absorbent layer, and a storage sealing member. The interface manifold may be positioned in fluid communication at the tissue site. The interface sealing member may be adapted to provide a sealed treatment space relative to the tissue site, and the interface manifold may be positioned in the sealed treatment space. The absorbent layer may be for positioning on an exterior facing side of the interface sealing member. The storage sealing member may be adapted to provide a sealed storage space between the storage sealing member and the exterior facing side of the interface sealing member. The absorbent layer may be positioned in the sealed storage space. Other systems, apparatuses, and methods are disclosed.

Abstract: A hanging device (100A) used in an additive solution transfer method includes an upper hanging section (106) and a support mechanism (lower hanging section (108)). The upper hanging section (106) is used to hang a medical fluid bag (54) upside down. The support mechanism (lower hanging section (108)) supports a primary bag (50) or a transfer line (55) in a predetermined state such that, when a red blood cell preservation liquid (M) is transferred from the medical fluid bag (54) to the primary bag (50) using the height difference between the primary bag (50) and the medical fluid bag (54), air from the medical fluid bag (54) is stopped in the middle of the transfer line (55).

Abstract: The various embodiments disclosed relate to straps that attach to manual breast pumps to allow the user to pump breast milk with leg power rather than by hand. One of two straps is wrapped around each of a user's thighs. Both straps have fasteners to enable the straps to be securely wrapped around the thigh. The straps are then connected to a manual breast pump. The breast pump can be connected to the manual breast pump by adding fasteners to the breast pump, or by threading the breast pump hoses through the pump connector. After the breast pump has been connected to the pump connectors, the user places the breast cup on their breasts. The user then begins pumping the manual pump by repeatedly moving their legs in an outward and inward motion.

Abstract: A mechanical fluid pressure modification valve, or “MFLP-valve”, is set forth. The MFLP-valve can be actuated upon movement of a movable pressure system member of a medical pressure system reaching a selected position. Additionally, the MFLP-valve can be actuated based on a pressure condition of the system. When the MFLP-valve unseals, a pressure differential between a pressure chamber and a volume outside of the chamber can be relieved. Disengagement of the movable pressure system member from the MFLP-valve can enable the MFLP-valve to re-seal. The MFLP-valve may include a flag that indicates the position of the movable pressure system member. The MFLP-valve may be provided in a diaphragm-type pressure source.

Abstract: Methods and systems are provided for the circulation of blood using a purge-free miniature pump. In one embodiment, a pump is provided that may comprise a housing including a rotor and a stator within a drive unit. In this embodiment, the pump may establish a primary blood flow through the space between the drive unit and the housing and a secondary blood flow between the rotor and stator. In another embodiment, a pump establishes a primary blood flow outside the housing and a secondary blood flow between the rotor and stator. In yet another embodiment, a method is provided for introducing the pump into the body and circulating blood using the pump.

Abstract: Blood pump assemblies and methods of manufacturing and operating blood pump assemblies are provided. The blood pump assembly includes a pump and an impeller blade rotatably coupled to the pump. The blood pump assembly also includes a pump housing component sized for passage through a body lumen and coupled to the pump. The pump housing component includes a peripheral wall extending about a rotation axis of the impeller blade. The peripheral wall includes an inner peripheral wall surface and an outer peripheral wall surface. The peripheral wall also includes one or more blood exhaust apertures. Each blood exhaust aperture in the one or more blood exhaust apertures is defined by an inner aperture edge and an outer aperture edge. Each inner aperture edge is chamfered between the inner peripheral wall surface and the outer peripheral wall surface.

Abstract: The present invention provides a rotary blood pump with both an attractive magnetic axial bearing and a hydrodynamic bearing. In one embodiment according to the present invention, a rotary pump includes an impeller assembly supported within a pump housing assembly by a magnetic axial bearing and a hydrodynamic bearing. The magnetic axial bearing includes at least two magnets oriented to attract each other. One magnet is positioned in the spindle of the pump housing while the other is disposed within the rotor assembly, proximate to the spindle. In this respect, the two magnets create an attractive axial force that at least partially maintains the relative axial position of the rotor assembly. The hydrodynamic bearing is formed between sloping surfaces that form tight clearances below the rotor assembly.

Abstract: In the field of contactless power transfer for medical devices, more specifically, to contactless power transfer for intra-corporeal medical devices, a system and method for transmitting power to a rechargeable power supply are provided, the rechargeable power supply comprising implantable power receiving means, and an implantable power storage means. The system comprises an extra corporeal power transmitting means arranged and configured to supply power to the rechargeable power supply by wirelessly transmitting power to the implantable power receiving means. The system and method are particularly useful in the context of minimally invasive procedures.

Abstract: A dialysis system comprises a filtration means, a pump and a sorbent device for performing a dialysis treatment and/or for regenerating a dialysate solution.