Abstract: The invention provides, in some aspects, a container system for medical solutions such as peritoneal dialysis (PD) solutions. The invention particularly features a system which includes a first compartment that contains a first medical solution, e.g., a PD osmotic agent, and a second compartment that contains a second medical solution, e.g., a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. To that end, a container system can include a diffuser that is disposed in a fluid pathway between the first and second compartments, e.g., to facilitate homogeneous mixing of the first and second PD agents.

Abstract: Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

Abstract: A control module for a medical injection system generates an injection control signal based on sensed internal pressure of a user activated control device, for example, in response to an applied external force that causes the sensed internal pressure to increase from a baseline pressure, and continues to sense the internal pressure of the device, following release of the applied external force, so that, if the sensed internal pressure drops below the baseline pressure, the control module may generate a notification. Thus, an operator of the system may monitor internal pressure of the control device for a drop below the baseline pressure, and then, if such a drop is detected, inspect the control device for leaks and reconnect, replace or repair the control device, or simply reconnect or replace the control device.

Abstract: A syringe includes a body and a plunger movably disposed within the body. The syringe may be used with an injector including a drive member. The drive member preferably includes at least one pin adapted to form a retractable abutting connection with an interior of a plunger to enable the drive member to retract the plunger with the body of the syringe.

Abstract: A system for delivery of a medical fluid to a patient includes a pump system including a pressurizing unit to pressurize the medical fluid and a drive system in operative connection with the pressurizing unit. The pump system exhibits variation in pressure during operation. The system further includes a compensating system in fluid connection with the medical fluid pressurized by the pressurizing unit. The compensating system defines a displacement volume in fluid connection with the pressurized medical fluid that is altered in a predetermined manner to alter the variation in pressure. The compensating system can, for example, reduce pulsatility of pressure during flow.

Abstract: Some embodiments of an infusion pump system can be configured to provide improved safety monitoring features so that a user receives proper dosage amounts.

Abstract: A system and method provide for enhanced reliability and safety of programming and/or operating a medical device, such as an infusion pump, with a remote control device, such as a mobile phone (e.g., a smartphone). A safety processor acts as an intermediary device between the smartphone and medical device to review transmissions from the smartphone prior to the transmissions being delivered to the medical device. The safety processor can determine whether the smartphone is compatible with the medical device by checking the type and version of the smartphone as well as the versions of the operating software and/or firmware resident on the phone. The safety processor can also check whether the operating command entered into the smartphone is within acceptable parameters.

Abstract: A novel set of flexible dialysis tube, needles, tubing and related attachments that may be used to improve the blood sampling, removal, and reinfusion process and reduce the medical hazards of such procedures for the patient. It consists in a special perforation needle over which a plastic tube is passed into the blood vessel, flexible dialysis tube remains inserted and opens gently then bends and morphs to the body structure assuring a good blood flow. A version of flexible dialysis tube may have inside valves and actuators so that bi-directional flow can be obtained following a single vessel puncture instead of two, for procedures such as hemodialysis. An exterior connection box allows a patient to connect to an external blood processing device (hemodialysis) quickly and safely. Further, the device is designed to stay in place for several days or more, further reducing the risks and discomforts of repeated vessel punctures.

Abstract: Aspects of the subject disclosure may include, for example, a system or biological sensor configured to initiate a timed procedure upon detecting a biological condition. Other embodiments are disclosed.

Abstract: An infusion system for infusing a liquid into a body includes an external infusion device and a remote commander. The external infusion device includes a housing, a receiver, a processor and an indication device. The receiver is coupled to the housing and for receiving remotely generated commands. The processor is coupled to the housing and the receiver to receive remotely generated commands and to control the external infusion device in accordance with the commands. The indication device indicates when a command has been received and indicates when the command is being utilized to control the external infusion device so that the external infusion device is capable of being concealed from view when being remotely commanded. The remote commander includes a commander housing, a keypad for transmitting commands, and a transmitter for transmitting commands to the receiver of the external infusion device.

Abstract: Methods, systems, and apparatuses integrating medical device data are disclosed. In an example embodiment, a vital sign monitor apparatus includes a renal failure therapy interface configured to receive a renal failure therapy parameter from a renal failure therapy machine performing a renal therapy treatment on a patient and an infusion pump interface configured to receive an infusion parameter from an infusion pump performing an infusion treatment for the same patient. The apparatus also includes a vital sign monitor engine configured to display, within a combination user interface of a vital sign monitor, the renal failure therapy parameter within a renal failure therapy timeline, and the infusion parameter within an infusion timeline that is aligned with the renal failure therapy timeline.

Abstract: The present invention relates to a filling device for filling a reservoir, the filling device comprising a housing configured to hold a container for a liquid; a conduit arranged for fluid engagement with the container; a drive unit configured to expel a liquid from the container through the conduit; and a connector configured to be attachable to a reservoir, wherein the connector comprises at least one contact element; the filling device further comprising a trigger assembly arranged to act on the drive unit such that when the trigger assembly is activated the liquid is expelled from the container through the conduit.

Abstract: A disposable cassette (1) for storing and delivering a medical drug, the cassette (1) comprising a cartridge (7) containing the medical drug, a waste reservoir (8) arranged to receive waste liquid and/or gas, an injection needle (9) ranged to deliver the medical drug, and a valve block (10) being movable between a first position and a second position. The first position establishes a fluid passage between the cartridge (7) and the waste reservoir (8), while preventing fluid flow from the cartridge (7) to the injection needle (9), and the second position establishes a fluid passage between the cartridge (7) and the injection needle (9), while preventing fluid flow from the cartridge (7) to the waste reservoir (8).

Abstract: The pharmaceutical injection device includes a main body case, a cartridge holder, a latching receiver, a driver, and an interface component. The cartridge holder has a holding space and a holder latching component. The holding space is capable of holding a pharmaceutical cartridge. The latching receiver latches or releases the holder latching component according to whether the cartridge holder is closed or open. The driver automatically releases the latching of the latching receiver and the holder latching component. The interface component manually releases the latching of the latching receiver and the holder latching component by moving the latching receiver upon being subjected to external pressure. The driver or the interface component releases latching between the latching receiver and the holder latching component.

Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Abstract: A medical cartridge containing multiple doses of a medical drug is disclosed. An outlet end is arranged to be connected to an injection needle for delivering the medical drug. The medical cartridge comprises a one way valve arranged in an interior part of the medical cartridge at a position near the outlet end. The one way valve allows a fluid flow from the interior of the medical cartridge towards the outlet end, but prevents a fluid flow from the outlet end towards the interior of the medical cartridge. Thereby the risk of contamination of the medical drug remaining in the cartridge is minimised.

Abstract: The subject matter of the present disclosure generally relates to a sensor assembly having a first component configured to melt when a temperature of the sensor assembly reaches a first value below a minimum value of a predetermined temperature range, a second component configured to melt when the temperature of the sensor assembly reaches a second value above a maximum value of the predetermined temperature range, and a third component configured to monitor a volume of fluid disposed in a vessel when the temperature of the sensor assembly is within the predetermined temperature range.

Abstract: A method of making a syringe assembly includes providing a first syringe component defining a first sliding surface that is substantially free of lubricant. The first sliding surface is contacted with water. The first sliding surface and the water in contact with the first sliding surface are heated at a temperature of at least 121° C. The first sliding surface is dried.

Abstract: The present invention relates to a A display arrangement for an injection device for displaying the size of a dose of a medicament, the display arrangement comprising: —a housing (60) providing a rotation axis (3) extending in an axial direction (4), —a first display member (22) rotatably supported inside the housing (60) with regard to the rotation axis (3) and having at least one cam (32) radially offset from the rotation axis (3), —a second display member (24) rotatably supported inside the housing (60) with regard to the rotation axis (3) and arranged axially adjacent to the first display member (24), —a coupling member (26) rotatably engaged with the second display member (24), wherein the coupling member (26) is engaged with the at least one cam (32) of the first display member (22) when the first display member (22) is in a predefined angular position or angular range, —wherein the coupling member (26) and the first display member (22) are mutually engaged via a retaining arrangement (48) when the cam

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: An assembly for a drug delivery device, comprising a housing having a proximal end and a distal end, a piston rod and an indicator. The piston rod is adapted to be displaced distally with respect to the housing away from a proximal start position and towards a distal end position for delivering a drug. The indicator is adapted for indicating at least two different operation conditions of the assembly, the indicator being moveable with respect to the housing from a first indication position for a first condition of the assembly into a second indication position for a second condition of the assembly. The piston rod and the indicator are configured to mechanically interact for converting movement of the piston rod into movement of the indicator. A first detent is provided which is configured to releasably secure the indicator in the first indication position such that movement into the second indication position is allowed.

Abstract: A medical article, such as a needle, includes an echogenic portion. The echogenic portion includes one or more patterns. The one or more patterns can include closely spaced surface features which provide enhanced echogenicity. The surface features can include grooves, recesses, channels, pits, pores, or the like. The grooves can be arranged in a zigzag shape in a needle body of the medical article. The zigzag shape can extend circumferentially around the needle body, that is, the grooves can extend perpendicularly to a longitudinal axis of the needle body. The zigzag shape provides enhanced echogenicity regardless of the section of the needle body underlying the ultrasound beam in use.

Abstract: An insulin infusion system is provided with a manual insertion device having a dual retraction spring (230) configuration for automatic introducer needle (222) retraction. A button (200) of the insertion device is used to insert the introducer needle (222) and catheter (202), and once the introducer needle (222) and catheter (202) have been fully inserted, a rotating engagement releases the dual retraction springs (230) such that the introducer needle (222) automatically retracts, leaving the catheter (202) in the body of the user. An end of the introducer needle (222) remains in the inserted catheter (202) and/or in the septum (206) of the inserted catheter (202) to provide an uninterrupted fluid path.

Abstract: A cannula adapter can include an adapter body, a breakpoint, and a coupling mechanism. The adapter body can have an interior channel with opposing openings. The first opening of the interior channel can be sized and shaped for insertion of a cannula and the second opening can be sized and shaped for a connection point of a medical device. The breakpoint can separate the adapter body into two discrete sections when an applied transverse force meets or exceeds its failure threshold, decreasing a likelihood of causing injury to a patient and the user of the medical device. The coupling mechanism can couple a bottom end of the adapter body to the connection point of the medical device, forming an air-tight connection between the cannula and the medical device that increases a failure threshold of the adapter body for withstanding applied longitudinal forces and torque.

Abstract: The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

Abstract: A needle that consists of two pieces, generally the second piece has two cylindrical parallel hollows; one hollow is much bigger than the other, the bigger hollow is for fluid entrance and the smaller hollow contains the first piece shaft; the first piece has a spring at the distal portion with an bicolored indicator for the movement of the first piece, and at the proximal portion it has a cylindrical shaft that moves forward and backward inside the smaller hollow of the second piece. When the hypodermic needle tip touches the skin or being inside a tissue the spring will be squeezed and the first piece will be situated backward in its primary position. Just when the tip of the needle enters any cavity or any vessel the spring will be freed and pushes the first piece forward with the change of the color of the bicolored indicator.

Abstract: the present invention relates to a device for a medicament delivery device, which extends along a longitudinal axis and comprises a medicament delivery member cover (18) arranged at a proximal end thereof; wherein the device comprises a delivery member protruding adjuster (28) operably connected to said medicament delivery member cover (18). The invention is characterised in that the device further comprises a signal generating mechanism (34) operably connected to said delivery member protruding adjuster (28) and arranged to provide an audible and/or tactile and/or visual signal indicating that a certain penetration depth has been set.

Abstract: A liquid reservoir (100) of a nebulizer has a funnel portion (102) with ribs (103, 104) extending downwardly along a side wall towards a reservoir outlet (105). The ribs (103, 104) prevent the formation of air bubbles between the aperture plate and medication as any trapped air will be expelled along the geometry formed by the rib or groove and reservoir wall. Bubble formation is therefore prevented with only modification of the wall internal surface configuration of the reservoir.

Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

Abstract: A delivery device for delivering a metered amount of substance (L) in response to exhalation by a user, the delivery device comprising: a mouthpiece (5) through which the user in use exhales; an outlet (45) from which substance Is delivered; and a dispensing unit (35) which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member (37) which includes a cavity (39) for containing a metered amount of substance, an outlet nozzle (43) which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing (41) member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle.

Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.

Abstract: The present disclosure relates to a leak detection system and method for tube or catheter placement. The system and method includes acoustically sensing a leak in the seal between a tube or catheter within a body and the body cavity against which it is sealed, assisting the user in adjusting the system until the leak has been substantially sealed, and establishing system parameters to be used thereafter to maintain the system in an operating state that will substantially prevent leakage, all using a noninvasive acoustic technique.

Abstract: The present invention provides improved dual lumen endobronchial tube devices. The dual lumen endobronchial tube devices feature a universal design for left or right mainstem bronchus insertion. The dual lumen endobronchial tube devices also feature enhanced balloon cuff designs to minimize dislodgement while maintaining proper airway sealing. The present invention also includes water activated lubricious coating inside the shaft to reduce friction during insertion of a bronchoscope into the airway. The present invention also provides improved double clamps that prevent the accidental clamping of both tubes of a Y-adapter.

Abstract: The invention concerns an apparatus for delivering a gas mixture to the nasal airways of a spontaneously breathing child, the apparatus comprises a soother (11), a body (1) forming a mixing chamber attached to the soother and adapted for positioning over the nostrils of the child, at least one gas delivering hose (2) attached to the body forming the mixing chamber for supplying gas to the mixing chamber, wherein the mixing chamber has access to the surrounding air and is adapted for mixing the supplied gas with the surrounding air in order to provide a gas mixture for nasal inhalation, and wherein the body forming the mixing chamber comprises an edge portion (8) with at least one non-contact section, which is adapted for having no contact with the child when the apparatus is in use thereby providing access from the surrounding air to the mixing chamber.

Abstract: A mask system has a shroud module with headgear connectors adapted to removably attach to respective headgear straps of headgear; and a cushion module, including a frame defining a breathing chamber; and a cushion to form a seal with the patient's face in a nasal bridge region, a cheek region and a lower lip/chin region of the patient's face. The cushion is constructed of a first, relatively soft, elastomeric material and the frame is constructed of a second material that is more rigid than the cushion, and a nasal bridge portion of the cushion includes one or more folds to provide in use a higher level of adaptability or flexibility to the nasal bridge region of the cushion module relative to another region of the cushion module. The shroud module and the cushion module are configured to be removably coupleable to one another.

Abstract: For reducing a discomfort feeling brought by wearing a breathing mask, a wearing tool for the breathing mask which covers nostrils of a user and supplies gas for breathing to the nostrils comprises a pair of connecting members each of which has a longitudinal shape and has a first end portion which is connected to the breathing mask, and a pair of fixing members each of which is connected to a second end portion of the fixing member and is plugged in the tragus of the user. Hence a discomfort feeling due to restraining around the head of the user can be reduced.

Abstract: The present invention pertains to a device (1) for the treatment of, treatment of complications arising from, and/or preventing respiratory disorders caused by bacterial, viral, protozoal, fungal and/or microbial infections, preferably for the treatment of complications arising from cystic fibrosis (CF), including a positive airway pressure device (2) for providing a breathing gas under a positive pressure to a patient interface (20), a source of nitric oxide (3) for providing gaseous nitric oxide, a gas injector (4) for injecting nitric oxide provided by the source of nitric oxide (3) into the breathing gas provided by the positive airway pressure device (2) under pressure, a flow rate sensor (5) for sensing the flow rate of the breathing gas provided to the patient interface (20) under positive airway pressure, and a controller (6) programmed for controlling the gas injector (4) for injecting the nitric oxide into the breathing gas provided by the positive airway pressure device (2) when a flow rate detecte

Abstract: A moving image in which a therapy target part repeatedly moves is displayed on a screen member along with a black background.

Abstract: An infant calming/sleep-aid/SIDS detection device is provided that includes a main moving platform that moves in a variable manner with accompanying variable sound generation, the sound and motion adapted to calm a fussy baby, induce sleep, and maintain sleep under normal conditions. The device may also have a sensor for detection of pauses in breathing and/or detection of resultant biological changes related to breathing pauses and respond with appropriate stimuli to arouse the baby and allow breathing to recommence.

Abstract: A sleep-aid device is provided that includes a main moving platform that moves in a variable manner with accompanying variable sound generation, the sound and motion under the control of a control system and adapted to calm a fussy baby, induce sleep, and maintain sleep under normal conditions. The device may also include a sleep sack for an infant, which is removably attachable to the sleep-aid device and comprises a crib attachment mechanism in data communication with the control system.

Abstract: A catheter includes a tubular inner layer, a reinforcement body disposed around the outer periphery of the inner layer, a protective layer covering the outer periphery of an end of the reinforcement body, and an outer layer covering at least the outer periphery of the protective layer. The protective layer covers the outer periphery of at least one end of reinforcement body, and the end of the reinforcement body covered with the protective layer is buried deeper in a side of the inner layer relative to a portion of the reinforcement body not covered with protective layer. The reinforcement body is prevented from lifting away from the inner layer when the catheter is bent even without increasing the outer diameter of the reinforcement body.

Abstract: The instant invention relates generally to catheters and to introducer catheters used to help deliver catheters or other medical devices to locations within the human body. In particular, the instant invention relates to large diameter catheters and introducer catheters having a torque transfer layer that includes at least two flat wires braided into a wire mesh. The flat wires have a width of at least about 0.007 inches and a depth of at least about 0.003 inches. The lumen diameter of the catheter is at least about 6 French. The torque transfer layer provides increased strength, flexibility, and kink resistance.

Abstract: A probe, consisting of a flexible insertion tube, for insertion into a subject via a body lumen. The probe includes a sequence of tubular modules contained within the insertion tube, each module having a rigid tube segment having a preset shape and containing internal grooves on an interior surface of the tube segment. The probe further includes a flexible expander tube, which is threaded through the sequence of tubular modules and has external grooves configured to engage the internal grooves within the tube segment of each of the tubular modules when the expander tube is expanded, so as to hold the tubular modules in mutual alignment, wherein the tubular modules are able to move out of mutual alignment when the expander tube is unexpanded. The probe also has an expansion element, which is insertable through the flexible expander tube so as to expand the expander tube.

Abstract: A tubular wall, which may be employed in a medical catheter or medical electrical lead, is formed by stranding together a plurality of polymer fibers and at least one metal filar, wherein the stranding forms a braid matrix of the polymer fibers and a coil of the metal filar interlaced therewith. Then, while the braid matrix secures a pitch of the coil, a polymer material is extruded around an entire length of the tubular wall, and, in some cases, the extrusion process causes the plurality of polymer fibers to melt and coalesce together with one another, while the pitch of the coil is maintained. Alternately, a reflow process, which follows extrusion, causes the polymer fibers to melt and coalesce along all, or just a discrete length of the tubular wall.

Abstract: A catheter tip for guiding the catheter through a patient's blood vessels and keeping the catheter in large vessels and preventing entry into smaller branch vessels.

Abstract: A catheter having improved ability to cross body passage obstructions and that more easily allows backloading of a guidewire into the lumen of the catheter is comprised of a tip, a shaft, and a lumen. The distal end of the catheter tip is oriented at an angle other than 90° to the lengthwise axis of the catheter lip. A guidewire may be easily backloaded into the elongated catheter lumen at the location of the angled catheter tip.

Abstract: An apparatus for preloading magnetic particles or cells onto a medical device includes a device carrier and a particle carrier attached over the device carrier. At least one magnet is inserted into the device carrier, the at least one magnet extending inside a section of the device carrier, over which the particle carrier is attached, to attract magnetic particles or cells to the particle carrier when the apparatus is placed in a suspension of magnetic particles or cells. A method for preloading magnetic particles or cells onto a medical device includes attaching one or more magnets to a device carrier, attaching a particle carrier to the device carrier in proximity to the one or more magnets, and inserting the device carrier with the attached particle carrier and the one or more magnets into a suspension containing magnetic particles or cells to preload the particle carrier with magnetic particles or cells.

Abstract: In one aspect, the present invention is directed to a multi-lumen catheter with self-sealing hub and an attachable extension assembly. In a preferred aspect, the present invention can allows removal of the external fluid connections of an elongated percutaneous medical article, such as a catheter or cannula. The percutaneous medical article suitably contains a distal septum that prevents fluid movement within the intraluminal space of the percutaneous medical article, when the fluid connections are removed. A single-use, disposable extension set of one or more single lumen lines with associated clamp and cap is attached for intraluminal access and removed following clinical use. Retaining the catheter transition allows the catheter to be secured using methods common to the art.

Abstract: A lead delivery apparatus and a method of delivering a medical lead to an anatomic target site. The method includes inserting a hydraulic plug into an internal delivery lumen of a delivery shaft, and coupling a medical lead to the hydraulic plug. Hydraulic pressure is applied to the hydraulic plug through the delivery lumen, thereby moving the hydraulic plug toward an anatomic target site, and advancing the medical lead toward the target site.

Abstract: An ultrasonic medical system comprising a tracking probe and a catheter is used for tracking a target inside human body. The ultrasonic probe has additional ultrasound sensors embedded around its main transducer array. A catheter is built with ultrasound transmitters at its distal end and sends active sound signals during each probe scanning cycle. The probe sensors track the 3D position of the target catheter using triangulation principle. The target position is rendered in the 3D anatomic context defined by the ultrasound images.