Patents Issued in March 2, 2017
  • THYMIDYLATE KINASE FUSIONS AND USES THEREOF
    Publication number: 20170056527
    Abstract: The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.
    Type: Application
    Filed: July 15, 2016
    Publication date: March 2, 2017
    Inventors: Jeffrey A. Medin, Sean Devine
  • MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
    Publication number: 20170056528
    Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
    Type: Application
    Filed: January 4, 2016
    Publication date: March 2, 2017
    Inventors: Antonin De Fougerolles, Atanu Roy, Jason P. Schrum, Suhaib Siddiqi, Paul Hatala, Stephane Bancel
  • NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN
    Publication number: 20170056529
    Abstract: The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein, particularly for the use in gene therapy. It also discloses its use for the preparation of a pharmaceutical composition, e.g. for use in gene therapy, particularly in the treatment of diseases which are in need of a treatment with a therapeutic peptide or protein, preferably as defined herein.
    Type: Application
    Filed: August 10, 2016
    Publication date: March 2, 2017
    Applicant: CureVac AG
    Inventors: Andreas THESS, Thomas SCHLAKE, Jochen PROBST
  • SYSTEMS AND METHODS FOR MATCHING ONCOLOGY SIGNATURES
    Publication number: 20170056530
    Abstract: Techniques to profile a disease or a disorder (e.g., a tumor) based on a protein activity signature are disclosed herein. An example method can include measuring quantitatively protein activity of a plurality of master regulator proteins in a sample from a disease or disorder; and profiling the tumor from the quantitative protein activity of the master regulator proteins. Also disclosed are methods of identifying a compound or compounds that treats diseases or disorders (e.g., inhibit tumor cell growth).
    Type: Application
    Filed: August 26, 2016
    Publication date: March 2, 2017
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrea Califano, Mariano Javier Alvarez
  • Fluorscent Probes To Assess Stannous Containing Oral Care Products
    Publication number: 20170056531
    Abstract: A method of quantitating sorption of stannous by microbial cells of a biofilm is an effective way of assessing efficacy of oral care products containing stannous.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 2, 2017
    Inventors: Yunming Shi, Ross Strand, Jinlan Chang, Tao He, Donald James White, JR., Yanyan He, Matthew Lloyd Barker, Weili Dong
  • HYPERPOLARIZED NOBLE GAS PRODUCTION SYSTEMS WITH NANOCLUSTER SUPPRESSION, DETECTION AND/OR FILTERING AND RELATED METHODS AND DEVICES
    Publication number: 20170056532
    Abstract: Systems, methods and related devices used to produce and collect polarized noble gas to inhibit, suppress, detect or filter alkali metal nanoclusters to preserve or increase a polarization level thereof. The systems can include a pre-sat chamber that has an Area Ratio between 20 and 500.
    Type: Application
    Filed: February 20, 2015
    Publication date: March 2, 2017
    Inventors: Matthew S. Freeman, Bastiaan Driehuys
  • Preparation Method for Magnetic Composite for Treating and Diagnosing Cancer
    Publication number: 20170056533
    Abstract: A preparation method for a magnetic composite for treating and diagnosing cancer. The method may include a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.
    Type: Application
    Filed: February 17, 2015
    Publication date: March 2, 2017
    Applicant: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Jae Moon Yang, Jin Suck Suh, Seung Joo Haam, Eu Gene Lee, Yoo Chan Hong, Min Hee Ku, Dan Heo, Seung Yeon Hwang, Yong Min Huh
  • Detecting a Therapeutic Cell
    Publication number: 20170056534
    Abstract: The present invention relates to a method of detecting a therapeutic cell expressing a dopamine transporter (DAT) at a central nervous system (CNS) site in a subject, which comprises the administration of a DAT tracer to the subject, wherein the presence of a therapeutic cell which expresses the DAT is determined.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 2, 2017
    Inventors: Martin Pulé, Adam Badar, Louise Kiru, Mark Lythgoe, Adrien Peters
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170056535
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 26, 2016
    Publication date: March 2, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Thomas Martin Krulle, Daniel Clark-Frew, Duane Higgins, Matthew Robert Mills, Richard Waldron Marston, Samuel Coe, Samantha Louise Jones Green, Sarah Hayes
  • ELECTROCHEMICAL MANIPULATION OF IMPLANTS
    Publication number: 20170056536
    Abstract: The present invention generally relates to systems and methods of treating microbial growth on a conducting surface, for example, the conducting surface of an implanted medical device. One embodiment of the method includes applying a electrical current through the conducting surface and a counter electrode. The electrical current is varied such that an electrical potential of the conducting surface alternates compared to the electrical potential of a reference electrode and where the electrical current is varied to an extent sufficient to reduce or prevent microbial growth on the conducting surface.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Applicant: RUSH UNIVERSITY MEDICAL CENTER
    Inventors: Nadim James Hallab, Ryan Freed, Dmitry Royhman, Steven P. Mell
  • SELF-SANITIZING ELECTRICAL MACHINE
    Publication number: 20170056537
    Abstract: A method for sanitizing an electric motor is provided. The method includes setting operational parameters for the electric motor for destroying targeted microbes; and energizing the electric motor using the set operational parameters. Computer program products and an electric motor are disclosed.
    Type: Application
    Filed: August 26, 2016
    Publication date: March 2, 2017
    Inventors: James Davison, Jerry Brown, Kevin Garrison
  • METHODS FOR INACTIVATING, ON MEDICAL INSTRUMENTS AND DEVICES, VIRUSES CONTAINING RNA AND DNA, AND APPARATUSES FOR IMPLEMENTATING SAME
    Publication number: 20170056538
    Abstract: Methods and apparatuses for inactivating RNA and DNA within viruses situated on medical instruments. Through the use of photochemicals and photoactivation by monochromatic light, medical instruments can be rendered safer. A solution of methylene blue having a concentration of 0.01-0.02% by means of interaction with light in the emission spectrum of monochromatic emitters having wavelengths ranging between 582 and 592 nm or between 658 and 662 nm and an overall light output of at least 280 lumens (lm), wherein the instruments are kept in said solution for about 90 minutes.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 2, 2017
    Inventor: Ovik Leonardovich Mkrtchyan
  • STERILIZATION DEVICE AND AN ELECTRON BEAM EMITTER
    Publication number: 20170056539
    Abstract: Sterilization device, in particular for sterilization of packaging material, comprising a first chamber, a barrier element and a connection area. The first chamber is adapted to provide charge carriers for sterilization, and the connection area is connected to a third chamber so that the barrier element forms at least one part of the boundary of a volume in which a first atmosphere exists.
    Type: Application
    Filed: January 21, 2015
    Publication date: March 2, 2017
    Applicant: TETRA LAVAL HOLDINGS & FINANCE S.A.
    Inventor: Håkan MELLBIN
  • DECONTAMINATION ENCLOSURE AND METHOD
    Publication number: 20170056540
    Abstract: Provided are a method and apparatus for decontaminating personal protective equipment while it is being worn by a person. A booth having a plurality of internally-reflective surfaces defines an interior space with dimensions suitable for receiving a standing person wearing the personal protective equipment. A plurality of UVC light sources are arranged to emit UVC light into the booth, and are operational while the person wearing the personal protective equipment is within the interior space. A door is selectively closeable to enclose the interior space and interfere with UVC light escaping the interior of the booth into an ambient environment of the booth, and a controller is operable to selectively operate the UVC light sources while the person wearing the personal protective equipment is standing within the interior space.
    Type: Application
    Filed: November 14, 2016
    Publication date: March 2, 2017
    Inventor: Roderick Dayton
  • CAP STERILIZATION
    Publication number: 20170056541
    Abstract: The invention relates to a device for sterilization of the interior surface of packaging containers with electron beam, comprising an emitter provided with an electron exit window. The emitter is adapted to emit charge carriers, such as electrons, through the electron exit window, said electrons forming an electron cloud. The device comprises at least one outlet adapted to provide a flow of sterile gaseous medium adapted to maintain a local aseptic zone around at least an emitter portion including the electron exit window, thus preventing any flow of medium from outside the local aseptic zone from coming into the local aseptic zone. The invention also relates to a method.
    Type: Application
    Filed: February 11, 2015
    Publication date: March 2, 2017
    Applicant: TETRA LAVAL HOLDINGS & FINANCE S.A.
    Inventor: Philip SVENINGSSON
  • AQUEOUS-BASED GELS, FREE-STANDING AIR FRESHENERS, AND METHODS FOR MANUFACTURING AQUEOUS-BASED GELS
    Publication number: 20170056542
    Abstract: Aqueous-based gels capable of free standing, free-standing air fresheners, and methods for manufacturing aqueous-based gels are provided herein. In accordance with an exemplary embodiment, an aqueous gel capable of free standing includes a C12-C24 fatty acid or a salt thereof, a freeze/thaw stabilizer, xanthan gum, a gluco- or galactomannan, and water. The xanthan gum and the gluco- or galactomannan are present in the aqueous-based gel in a xanthan gum:gluco- and/or galactomannan ratio in the range of about 50:50 to about 75:25.
    Type: Application
    Filed: August 27, 2015
    Publication date: March 2, 2017
    Inventors: Alex Hamilton, Kevin Hafer, Tyler Mikkelsen
  • AIR DECONTAMINATION DEVICE & METHOD
    Publication number: 20170056543
    Abstract: A device for air decontamination comprises a housing (10) having an air inlet (14), an air outlet (16) and an air flow passage (12) therebetween, the housing including at least one non-thermal plasma cell (22); wherein the non-thermal plasma cell is sized and positioned relative to the internal dimensions of the housing such that a portion of air entering the housing from the air inlet is adapted to pass through and across the non-thermal plasma cell and a portion of air entering the housing from the air inlet is adapted to pass outside of the external surface of the non-thermal plasma cell. A method of decontaminating air is also disclosed.
    Type: Application
    Filed: February 10, 2015
    Publication date: March 2, 2017
    Inventor: LORRAINE INGRID BALDRY
  • POLYMER NANOFIBER SCAFFOLDS AND USES THEREOF
    Publication number: 20170056544
    Abstract: A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
    Type: Application
    Filed: February 10, 2015
    Publication date: March 2, 2017
    Applicant: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jonathan K Pokorski, Eric Baer, Kim Sieun, Jia Wang
  • PROCESS FOR MANUFACTURING ABSORBENT SANITARY PAPER PRODUCTS
    Publication number: 20170056545
    Abstract: A method of manufacturing an absorbent sanitary paper product is disclosed. The method comprises the steps of: forming a nonwoven structure by spinning filaments; applying a plurality of fibers to the nonwoven structure to form a first network of fibers having a first and a second side and wherein the fibers and the filaments comprising the first network of fibers have a longitudinal axis generally disposed within the plane comprising the machine- and cross-machine-directions; applying a first bonding layer in a first pattern to one of the first and second sides of the first network of fibers; and, applying a first second network of fibers to the first bonding layer, the first second network of fibers comprising a combination of a first plurality of fibers and a second plurality of fibers, the first and second pluralities of fibers being different.
    Type: Application
    Filed: November 11, 2016
    Publication date: March 2, 2017
    Inventors: Thomas Timothy BYRNE, Kevin Benson McNEIL, Kathryn Christian KIEN
  • SURGICAL ADJUNCTS HAVING MEDICANTS CONTROLLABLY RELEASABLE THEREFROM
    Publication number: 20170056546
    Abstract: Surgical adjuncts having medicants controllably releasable therefrom are provided. In general, an adjunct retaining at least one medicant controllably releasable therefrom can be configured to be responsive to one or more physiological triggers. The adjunct can be provided with the at least one medicant releasably retained within the adjunct. In general, the one or more physiological triggers can each include an environmental condition to which the adjunct is exposed, such as when the adjunct is positioned within a body, such as by being stapled to tissue. Various physiological triggers can affect the adjunct, causing the adjunct to release the at least one medicant to the surrounding tissue in a selectable elution profile depending on the physiological trigger(s) that affect a particular adjunct.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 2, 2017
    Inventors: Frederick E. Shelton, IV, Jason L. Harris
  • SURGICAL ADJUNCTS AND MEDICANTS FOR PROMOTING LUNG FUNCTION
    Publication number: 20170056547
    Abstract: Surgical adjuncts and medicants for promoting lung function are provided. In general, an implantable adjunct can have one or more medicants releasably retained therein that are configured to promote lung function. The adjunct can be configured to be applied to lung tissue in conjunction with surgical staples using a surgical stapler. The one or more medicants can be configured to promote lung function in a variety of ways. For example, the one or more medicants can be effective to increase oxygen concentration. For another example of the one or more medicants being configured to promote lung function, the at least one medicant can be configured to treat contaminants in lung tissue.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 2, 2017
    Inventors: Michael J. Vendely, Frederick E. Shelton, IV, Jason L. Harris
  • MULTIBRANCHED BIOADHESIVE COMPOUNDS AND SYNTHETIC METHODS THEREFOR
    Publication number: 20170056548
    Abstract: The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 2, 2017
    Inventors: Bruce P. Lee, Sunil Silvary, John L. Murphy
  • Meniscal Repair Adhesive
    Publication number: 20170056549
    Abstract: A composition that includes (a) a prepolymer having at least one free isocyanate group that is capable of bonding to tissue and that cures in vivo upon exposure to water to form a polymer having a compressive modulus between 1.9 and 14.4 MPa and a tensile modulus between 5.0 and 30, and (b) an oil that is miscible in the prepolymer, the oil being selected from the group consisting of silicone oils, mineral oil, vegetable oils, and combinations thereof. The composition retains its integrity when delivered in an aqueous medium.
    Type: Application
    Filed: August 31, 2016
    Publication date: March 2, 2017
    Inventors: Dottie M. Clower, Eric J. Beckman, Bradd N. Picone
  • LYOPHILIZED POLYMER SCAFFOLD COMPOSITIONS, PROCESSES FOR PREPARATION AND USE IN ANABOLIC WOUND REPAIR
    Publication number: 20170056550
    Abstract: The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.
    Type: Application
    Filed: February 20, 2015
    Publication date: March 2, 2017
    Applicant: ORTHO REGENERATIVE TECHNOLOGIES INC.
    Inventors: Caroline Hoemann, Daniel Veilleux, Michael D. Buschmann
  • Sophorolipid Mediated Accelerated Gelation of Silk Fibroin
    Publication number: 20170056551
    Abstract: The present invention provides a biocompatible hydrogel composition comprising glycolipids and silk fibroin (SF) wherein glycolipid is preferably sophorolipids (SL). The said composition is useful in preparation of 3D scaffold for use in tissue engineering, and in the biomedical field. The present invention also provides a process for preparing such a composition and a process for acceleration of gelation time of silk fibroin (SF) in the presence of sophorolipid.
    Type: Application
    Filed: May 8, 2015
    Publication date: March 2, 2017
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Parul DUBEY, Philem Pushparani DEVI, Anuya Amol NISAL, Asmita Ashutosh PRABHUNE
  • Discontinuous Coating Method Using A Bioabsorbable And Bioactive Biomaterial Applied To Solid Substrates, Discontinuous Coating And Use Thereof
    Publication number: 20170056552
    Abstract: The invention relates to the development of a discontinuous coating using a bioabsorbable and bioactive biomaterial (which can be a bioceramic, a biopolymer or a bioactive composite) applied to solid (smooth, rough or porous) substrates. This discontinuous coating should be totally consumed in up to 10 days after implantation, so that in the end only the interface of the newly formed tissue with the implant remains. The proposed discontinuous coating can be obtained by any method that allows depositing a continuous layer, once the process parameters are duly adjusted. The preferred method for applying this discontinuous layer is airbrushing or air atomizing. The preferred biomaterial is bioglass.
    Type: Application
    Filed: February 18, 2015
    Publication date: March 2, 2017
    Inventors: Edgar Dutra Zanotto, Oscar Peitl Filho, Clever Ricardo Chinaglia
  • COMPOSITION INCLUDING BIOACTIVE BONE GRAFTING MATERIALS AND A METALLIC SURFACE COATING, METHOD OF MAKING AND USING THE COMPOSITION
    Publication number: 20170056553
    Abstract: Compositions including bioactive glass ceramic material surface-coated with a metallic material and methods of making and using the metallic material-coated compositions.
    Type: Application
    Filed: August 30, 2016
    Publication date: March 2, 2017
    Applicant: NovaBone Products, LLC
    Inventors: Gregory J. Pomrink, Zehra Tosun, R. Layne Howell
  • FGF-18 IN GRAFT TRANSPLANTATION AND TISSUE ENGINEERING PROCEDURES
    Publication number: 20170056554
    Abstract: The present invention provides a new method related to regenerative medicine for the treatment of cartilage disorders, osteoarthritis and cartilage injury in particular. More particularly, it relates to an FGF-18 compound for use in tissue engineering and graft procedures, such as osteochondral or cartilage transplantation or autologous chondrocyte implantation (ACI).
    Type: Application
    Filed: February 20, 2015
    Publication date: March 2, 2017
    Inventors: CHRISTOPH H. LADEL, HANS GUEHRING, ANNE GIGOUT
  • LIPOSOME FOR DELIVERING EXTRACELLULAR MATRIX
    Publication number: 20170056555
    Abstract: The present disclosure provides a liposome for delivering an extracellular matrix, a method for promoting cell growth, and a method for preparing a liposome for delivering an extracellular matrix. According to the present disclosure, the liposome for delivering an extracellular matrix promotes cell attachment and growth, and through this matter, the liposome for delivering an extracellular matrix can be applied to cell or tissue regeneration.
    Type: Application
    Filed: April 18, 2016
    Publication date: March 2, 2017
    Inventors: Kwan Woo SHIN, Keel Yong LEE, Tae Kyu AHN, Gi Yoong TAE
  • ENHANCEMENT OF OSTEOGENIC POTENTIAL OF BONE GRAFTS
    Publication number: 20170056556
    Abstract: The present invention concerns the enhancement of the osteogenic potential of bone graft by ex vivo treatment with a Wnt polypeptide, such as a liposomal Wnt polypeptide.
    Type: Application
    Filed: March 7, 2016
    Publication date: March 2, 2017
    Inventors: Jill Helms, Girija Dhamdhere
  • THREE-DIMENSIONAL SILK FIBROIN SCAFFOLD CULTURE RETAINING FUNCTIONAL SALIVARY CELLS AND PROMOTING SALIVARY TISSUE-SPECIFIC ECM SYNTHESIS
    Publication number: 20170056557
    Abstract: A cell culture system including a silk fibroid scaffold, culture media, and salivary gland cells. The salivary gland cells grown in the tissue culture system have physiological and morphological features like those of in vivo salivary gland cells. The cell culture system can be used to produce a salivary tissue-specific extracellular matrix capable of inducing differentiation of salivary gland cell precursors into salivary gland cells.
    Type: Application
    Filed: February 9, 2015
    Publication date: March 2, 2017
    Inventors: Xiao-Dong Chen, Chih-ko Yeh, Joo L. Ong
  • Gene Therapy
    Publication number: 20170056558
    Abstract: Use of cyclosporin A (CsA) or a derivative thereof for increasing the efficiency of transduction of an isolated population of human haematopoietic stem and/or progenitor cells by a vector derived from HIV-1, HIV-2, FIV, BW, EIAV, CAEV or visna lentivirus.
    Type: Application
    Filed: April 24, 2015
    Publication date: March 2, 2017
    Inventors: Anna Kajaste-Rudnitski, Eugenio Montini
  • Active Agent-Particle Combination Supporting Bone Regeneration
    Publication number: 20170056559
    Abstract: The invention provides for a bioactive composition comprising solid particles, such as e.g. calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate. The drug-loaded particles are included into a carrier that is preferably composed of a polymeric matrix, such as for instance a hyaluronic acid-based hydrogel. The composition is particularly useful for the treatment of bone defects, including dental-related pathological conditions, and particularly for bone regeneration/healing. The composition can be applied and/or injected directly in situ to perform its action on the bone defect. A pharmaceutical composition comprising the bioactive composition is also disclosed herein.
    Type: Application
    Filed: March 5, 2015
    Publication date: March 2, 2017
    Inventors: Ulrike Kettenberger, Dominique Pioletti
  • IMPLANT COMPRISING FGF-18
    Publication number: 20170056560
    Abstract: The invention relates to the field of pharmaceutical compositions. More particularly it is directed to substance delivery system (or implant), such as scaffolds and membranes, comprising an anabolic drug, such as a Fibroblast Growth Factor 18 (FGF-18) compound, to methods of producing such delivery system, as well as use thereof. The implants according to the invention are for use for the treatment of cartilage disorders, such as osteoarthritis, cartilage injury or osteochondral defects.
    Type: Application
    Filed: February 20, 2015
    Publication date: March 2, 2017
    Inventors: CHRISTOPH H. LADEL, HANS GUEHRING
  • COMPOSITIONS FOR THE TREATMENT OF JOINTS
    Publication number: 20170056561
    Abstract: A composition for treating a joint condition, the composition comprising: hyaluronic acid; and taurolidine.
    Type: Application
    Filed: August 31, 2016
    Publication date: March 2, 2017
    Inventors: Robert DiLuccio, Bruce Reidenberg, Randy Milby
  • BIOERODIBLE MAGNESIUM ALLOY MICROSTRUCTURES FOR ENDOPROSTHESES
    Publication number: 20170056562
    Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.
    Type: Application
    Filed: November 15, 2016
    Publication date: March 2, 2017
    Inventor: Jacob Drew Edick
  • SURFACE-MODIFIED METAL AND METHOD FOR MODIFYING METAL SURFACE
    Publication number: 20170056563
    Abstract: Provided are surface-modified metals and methods for modifying a metal surface, which involve a lubricating surface layer chemically fixed to the metal surface to provide excellent lubricity and excellent lubricant durability, and further which have good productivity and good economic efficiency. Included is a surface-modified metal whose surface is at least partially provided with a treatment layer having a thickness of 50 to 800 nm, the treatment layer being formed by treating a surface of a metal with a silane coupling agent, followed by adsorbing a hydrogen abstraction type photopolymerization initiator onto the surface and then polymerizing a monomer.
    Type: Application
    Filed: July 29, 2016
    Publication date: March 2, 2017
    Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa MINAGAWA
  • ABSORBABLE, PERMEABILITY-MODULATED BARRIER COMPOSITES AND APPLICATIONS THEREOF
    Publication number: 20170056564
    Abstract: Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
    Type: Application
    Filed: November 13, 2016
    Publication date: March 2, 2017
    Applicant: POLY-MED, INC.
    Inventor: Shalaby W. Shalaby
  • ANTIBIOTIC DRUG RELEASE SHEATH
    Publication number: 20170056565
    Abstract: An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is sealed with a biocompatible pressure responsive coating; wherein the biocompatible coating is stable for at least 7-day post implantation into a body, and can be mechanically ruptured by application of an exterior pressure generating force.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Applicants: Thomas Jefferson University, Drexel University
    Inventors: Christopher K. Kepler, Alex Michael Sevit, Steven Michael Kurtz, Noreen J. Hickok, Flemming Forsberg, John R. Eisenbrey
  • ADJUNCT MATERIAL TO PROMOTE TISSUE GROWTH
    Publication number: 20170056566
    Abstract: Adjunct material to promote tissue growth is provided. In general, an implantable adjunct can be configured to be applied to tissue by a surgical stapler in conjunction with staples. The adjunct can have one or more medicants releasably retained therein that are effective to provide a desired effect on tissue in-growth in a predetermined manner. One or more characteristics associated with the adjunct can be altered between various implementations to promote organized tissue remodeling in a desired manner during wound healing, such as by encouraging tissue growth to be in a certain direction and/or by discouraging tissue growth in a certain area and/or on a certain structure.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 2, 2017
    Inventors: Frederick E. Shelton, IV, Chad E. Eckert, Michael J. Vendely, Jason L. Harris
  • Composite Adjunct Materials for Delivering Medicants
    Publication number: 20170056567
    Abstract: Various exemplary composite adjunct materials for delivering medicants are provided. In general, the adjunct material can be configured to be delivered to tissue by deployment of staples from a cartridge body of a surgical stapler. The adjunct material includes a conformable region and a distinct reinforcing region that form the composite structure. An effective amount of at least one medicant can be disposed within and releasable from at least one of the conformable region and the reinforcing region and can provide a desired effect on tissue in-growth in a predetermined manner.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 2, 2017
    Applicant: ETHICON ENDO-SURGERY, LLC
    Inventors: Jason L. Harris, Michael J. Vendely, Chad E. Eckert, Frederick E. Shelton, IV
  • Adjunct Material to Provide Drug Elution from Vessels
    Publication number: 20170056568
    Abstract: Adjunct material is provided that has multiple reservoirs formed therein and releasably carrying a plurality of vessels that each retain at least one medicant. An implantable adjunct has at least one bioabsorbable polymer configured to maintain the vessels within a reservoir. Disruption of the at least one bioabsorbable polymer allows release of the vessels from at least one of the reservoirs. A rate of the vessels' release can be controlled by a degradation rate of the at least one bioabsorbable polymer. The released vessels are, in turn, disrupted to thereby cause at least one medicant disposed therein to release and thus provide a desired effect on tissue in-growth.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 2, 2017
    Inventors: Frederick E. Shelton, IV, Tamara S. Widenhouse, Michael J. Vendely, Jason L. Harris
  • Adjunct Material to Provide Controlled Drug Release
    Publication number: 20170056569
    Abstract: Adjunct material retained by a staple cartridge assembly is provided. The adjunct material provides elution of medicants therefrom such that release of one medicant regulates release of another medicant. A first medicant is released as a bolus dose substantially immediately upon delivery of the adjunct material to tissue. The second medicant is associated with the staple cartridge assembly in a manner such that release of the second medicant to tissue is regulated by the release of the first medicant.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 2, 2017
    Inventors: Michael J. Vendely, Chad E. Eckert, Frederick E. Shelton, IV, Jason L. Harris
  • TUBULAR DRAINAGE DEVICE
    Publication number: 20170056570
    Abstract: A medical device for draining a fluid from the body of a patient includes a tubular member having an open distal end that resides interiorly of the body of a patient and a proximal end that extends exteriorly of the body of the patient. The tubular member has an inner surface extending between the distal end and the proximal end, wherein the inner surface defines a lumen. An interior member is disposed in the lumen and extends along a length of the inner surface. The interior member is engaged with the inner surface such that a chamber is defined therebetween. A conduit is engaged with the tubular member for transmission of an inflation fluid to selectively vary a dimension of the chamber for freeing clogged debris in the lumen.
    Type: Application
    Filed: April 4, 2016
    Publication date: March 2, 2017
    Applicant: COOK MEDICAL TECHNOLOGIES LLC
    Inventor: KURT J. TEKULVE
  • Minimally Invasive Suction Sleeve
    Publication number: 20170056571
    Abstract: A minimally invasive surgery suction sleeve configured for use with an inner cannula of a suction instrument. The sleeve includes a first opening at a proximal end, a second opening at a distal end, and a tube between the first opening and the second opening. The sleeve slides over a suction instrument. The distal end is configured to insert into the body and includes a plurality of apertures that provide for pool suction. The sleeve further includes a flange at the proximal end that allows a surgeon to manipulate the sleeve, switching between spot and pool mode by sliding the sleeve over the inner cannula of the suction instrument. In spot mode, the tip of the suction instrument is exposed. In pool mode, the sleeve slides forward, covering the tip of the suction instrument so that fluent material is drawn through the apertures in the sleeve.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Applicant: Santanello Surgical, LLC
    Inventor: Steven Santanello
  • WOUND CLOSURE AND DRAINAGE SYSTEM
    Publication number: 20170056572
    Abstract: A vacuum system for draining an open wound from liquids exuded therefrom, comprising an enclosure sealable to the wound circumference, a vacuum pump including a disposable pump unit detachably attachable to a non-disposable drive unit, and a waste container for collection of drained liquids. The enclosure has an outlet connected by means of a tube to an inlet of the pump unit and the waste container is connected to an outlet of the pump unit, such that when the vacuum pump is operated the drained liquids flow through the vacuum pump. The enclosure has one or more bleeding holes provided therethrough or adjacent to its outlet so that ambient air may enter the tube and flow together with the drained liquids.
    Type: Application
    Filed: November 16, 2016
    Publication date: March 2, 2017
    Inventor: Carmeli ADAHAN
  • Lacteal Extractor Safety System and Method for Pump System
    Publication number: 20170056573
    Abstract: A mechanical over-vacuum safety system and method of use for a vacuum pump system designed to extract milk from lactating mothers. The over-vacuum safety system includes at least one mechanical safety valve configured to reduce a vacuum in the pump system given an over-vacuum condition. The mechanical safety valve(s) may be automatically actuated in response to specific vacuum ranges, such as an over-vacuum conditions ranging between negative 350 mmHG to negative 300 mmHG. The mechanical safety valve may allow fluid flow by folding.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Inventor: Raymond Holtz
  • CATHETER FOR THE DIRECTIONAL CONVEYANCE OF A FLUID, PARTICULARLY A BODY FLUID
    Publication number: 20170056574
    Abstract: A catheter for the directional conveyance of a fluid, in particular a body fluid, is provided. The catheter includes a sleeve having an internal space and a frame. The sleeve has at least three openings and is configured at least in a region between the first opening and the second opening as a conduit for the fluid. A check valve is arranged at the second opening. The check valve includes a valve foil which is at least partially attached to the sleeve such that the second opening can be completely covered by the valve foil.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 2, 2017
    Inventors: Joerg Pfeifer, Ronald Reich
  • DIALYSIS CATHETER AND METHODS OF USE THEREOF
    Publication number: 20170056575
    Abstract: The present invention relates generally to medical devices for use in peritoneal dialysis and to methods of using such devices. One aspect of the invention provides a device including an elongated tubular member having a lumen extending from a proximal end to a distal end and a first expandable member positioned around the elongated tubular member at a first position. A second expandable member is positioned around the elongated tubular member at a second position distal of the first position. The wall of the elongated tubular member between the first and second expandable members is free of an opening providing a fluid path between the lumen and an exterior of the device. The elongated tubular member may be reinforced along at least a portion of its length.
    Type: Application
    Filed: August 24, 2016
    Publication date: March 2, 2017
    Applicant: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: Kalub Hahne, Emma Moran, Sarah Septiani, Amy Ham
  • PLASMA GENERATION WITH DIALYSIS SYSTEMS
    Publication number: 20170056576
    Abstract: Embodiments for a blood plasma and red blood cell generation device are disclosed. The device may operate as an alternative modality of the dialysis machine, as part of the dialysis machine and/or as an add-on module. The fluid handling components of the plasma generation system may be integrated with a microprocessor unit for controlling and executing generation of plasma, or a control unit of the dialysis machine may be adapted to control the plasma generation aspects of the treatment.
    Type: Application
    Filed: August 27, 2015
    Publication date: March 2, 2017
    Inventors: Matthew Doyle, Alexander Joseph Brown