Patents Issued in March 30, 2017
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Publication number: 20170087045Abstract: A device for the prevention of stroke is provided that has a processor, a compression system, a compression member, and a vascular probe carried by the compression member. The vascular probe senses a parameter of a circulation system from a closed neck artery that is not being externally accessed. The processor processes the closed parameter and based upon this processing communicates with the compression system to instruct the compression system to actuate the compression member. The compression member and vascular probe are external to the interior of the patient when the vascular probe senses the closed parameter of the circulation system.Type: ApplicationFiled: September 21, 2016Publication date: March 30, 2017Inventor: MICHAEL ZHADKEVICH
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Publication number: 20170087046Abstract: An external counterpulsation apparatus has an efficient cuff and bladder system. Embodiments of this system generally allow effective treatment at lower pressures and a reduced total body surface area being compressed. An accurate and reliable combination of automatic and preset timing for inflation and deflation of the bladder system is used to simplify use of the apparatus. Depressurization of the cuffs may occur in a staggered fashion.Type: ApplicationFiled: December 12, 2016Publication date: March 30, 2017Inventors: David Anthony Pickett, James Russell Lusk
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Publication number: 20170087047Abstract: A massage head including a casing forming an internal chamber defined by a back wall, two lateral walls, and two transverse walls, and open on its surface opposite to the back wall, and having a skinfold formed therein when the head is applied to a patient's skin. The head is formed of two modules provided with means capable of enabling to reversibly fasten them to each other. Each of the modules integrates a functional element defining one of the transverse walls of the internal chamber.Type: ApplicationFiled: April 17, 2015Publication date: March 30, 2017Applicant: LPG SYSTEMSInventor: Arnaud Fuster
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Publication number: 20170087048Abstract: A massage roller comprises a central spinal recess portion, a circular wall portion on each side of the spinal recess portion, and an outer portion extending outwardly from each of the circular wall portions, the outer portion having a first diameter at or near the circular wall portion, and a second diameter remote from the circular wall portion, the second diameter being larger than the first diameter.Type: ApplicationFiled: October 6, 2016Publication date: March 30, 2017Inventor: Michael A. Cohen
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Publication number: 20170087049Abstract: The modular adult toy includes a base module with a housing having a first connection half at one end; and at least one shaft module. Each shaft module includes a body having a second connection half at one end and a first connection half at an opposite end. There is a head module having a body having a second connection half at one end. Each of the first connection halves are configured to be releasably connectable with any second connection half.Type: ApplicationFiled: September 29, 2015Publication date: March 30, 2017Inventor: Timothy Daniel HUTCHISON
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Publication number: 20170087050Abstract: The present invention provides an apparatus and methods to deliver audible acoustic sound to the brain through bone conduction and to terminate snoring and sleep apnea. The apparatus comprises a control module and a device that measures signs of the snoring and the sleep apnea and generates the audible acoustic sound to arouse a subject. The device is reversibly attachable to a part of a head overlying a skull of the subject and uses a composite sensor comprising a reflectance pulse oximeter and a vibration sensor for the measurement and an acoustic speaker for generation of the sound. The device drives the acoustic speaker to produce human-conversational sound and non-human sound.Type: ApplicationFiled: September 30, 2015Publication date: March 30, 2017Inventor: Choon Kee Lee
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Publication number: 20170087051Abstract: A stress cone (10) for massaging tight back muscles of a human body, the stress cone being a conical shaped body (11) with a rounded tip (12) at one end and an opposed concave base (14) at an opposed end. The stress cone (10) is typically made of solid rubber or other rigid but slightly compressible materials, and in some embodiments features a hollow core (18) for housing a vibrating motor (20). In use, the stress cone (10) is affixed to a wall via the concave base (14), and a user positions an identified pressure point of his or her body against the tip (12) and applies body pressure to the tip. The user can move side to side or up and down against the stress cone, massaging the muscles located at the pressure point to loosen them.Type: ApplicationFiled: June 20, 2016Publication date: March 30, 2017Inventor: Donald Oscar Deem
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Publication number: 20170087052Abstract: This disclosure relate to a CPR assistance device, an intelligent terminal, and a CPR assistance system. The CPR assistance device is used to assist a rescuer in performing CPR, comprises a wearing bulk, and further comprises a compression information acquiring module (11) and a processing module (12); the compression information acquiring module (11) is provided on the wearing bulk, and configured to acquire a moving amplitude and/or an actual rate of moving of the wearing bulk when the rescuer performs a chest compression; the processing module (12) is connected with the compression information acquiring module (11), and can generate an amplitude and/or a rate control signal.Type: ApplicationFiled: November 27, 2015Publication date: March 30, 2017Applicant: BOE Technology Group Co., Ltd.Inventor: Zhenfu Ma
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Publication number: 20170087053Abstract: A method of processing a raw acceleration signal, measured by an accelerometer-based compression monitor, to produce an accurate and precise estimated actual depth of chest compressions. The raw acceleration signal is filtered during integration and then a moving average of past starting points estimates the actual current starting point. An estimated actual peak of the compression is then determined in a similar fashion. The estimated actual starting point is subtracted from the estimated actual peak to calculate the estimated actual depth of chest compressions. In addition, one or more reference sensors (such as an ECG noise sensor) may be used to help establish the starting points of compressions. The reference sensors may be used, either alone or in combination with other signal processing techniques, to enhance the accuracy and precision of the estimated actual depth of compressions.Type: ApplicationFiled: December 13, 2016Publication date: March 30, 2017Inventors: James A. Palazzolo, Darren R. Sherman, Ronald D. Berger, Henry R. Halperin
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Publication number: 20170087054Abstract: A pulmonary expansion therapy (PXT) device may be a handheld device that covers specific lung fields and may generate negative pressure fields locally. The device also may provide percussion therapy for airway clearance. The PXT may generate a localized negative pressure field non-invasively to the exterior of the chest wall, thereby increasing the functional residual capacity in underlying lung fields. As a result, increased ventilation and perfusion to the targeted internal lung field may be achieved by creating a decrease in the external barometric pressure relative to the more positive intrinsic airway pressures. The PXT device also may improve lung compliance by enabling a medical professional such as a Respiratory Therapist/Care provider to grab and elevate the chest wall to compensate for the dysfunction of the respiratory musculature responsible for lifting the chest wall during normal breathing.Type: ApplicationFiled: September 25, 2015Publication date: March 30, 2017Inventor: Peter Antros
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Publication number: 20170087055Abstract: Disclosed is an optical needle comprising a coupling seat, a needle body in connection with the coupling seat and at least an optical fiber. The needle body comprises a lightguide groove extended along the length direction of the needle body to accommodate a portion of the optical fiber. The coupling seat provides a junction plane to couple a light source. An end of the lightguide groove is aligned with the junction plane, so to align an end of the optical fiber with the junction plane. The optical needle is characterized in that the long axis of the optical fiber reduces from a section aligned with the junction plane to an end adjacent to the needle body. A method for preparation of the optical needle is also disclosed.Type: ApplicationFiled: January 29, 2016Publication date: March 30, 2017Inventor: Hsiao-Sen Tseng
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Publication number: 20170087056Abstract: A blister card with a back side and a front side opposite the back side. The front side has a plurality of blisters and each blister contains a unit dose and each unit dose contains an active. Each blister card contains from about 12 hours to about 24 hours of unit doses according to the dosage instructions. The actives can be the same or different.Type: ApplicationFiled: November 17, 2016Publication date: March 30, 2017Inventors: Rosa Manuela Leon Alonso, Kelly Lee Schmeichel, Isabelle La Fosse-Marin, Angela Jane Deutsch, Thomas Alfred Inglin, Kurt Franklin Trombley, Diane Danheiser Powers, Eduardo De Abreu Mangione, Craig Andrew Hawkins, Jay Robert Morosey, JR.
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Publication number: 20170087057Abstract: An adaptor for coupling with a medical container, including: a tubular body receiving a pierceable elastomeric piece, defining an inner cavity of the adaptor, the pierceable elastomeric piece being movable within the tubular body between a first position, in which a distal part of the pierceable elastomeric piece forms a seal of the cavity, and a second position, proximally spaced from the first position, in which the distal part opens the seal of the cavity, an air inlet, a filtering system for filling the inner cavity with decontaminated air, and a gripping member for securing the adaptor to the medical container. Also, an assembly comprising such an adaptor and a medical container.Type: ApplicationFiled: December 9, 2016Publication date: March 30, 2017Inventors: Laurent Barrelle, Anthony C. J. Fernando
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Publication number: 20170087058Abstract: Glass pharmaceutical packages with coatings are disclosed herein. According to one embodiment, the glass pharmaceutical package includes a glass body enclosing an inner volume and having an exterior surface. A coating may be positioned on at least a portion of the exterior surface of the glass body. The coating may include a coupling agent layer having a first thickness of greater than or equal to 25 nm and less than or equal to 100 nm. A polymer layer having a second thickness of less than 50 nm may be positioned over the coupling agent layer.Type: ApplicationFiled: December 9, 2016Publication date: March 30, 2017Applicant: Corning IncorporatedInventors: Andrei Gennadyevich Fadeev, Theresa Chang, Dana Craig Bookbinder, Santona Pal, Chandan Kumar Saha, Steven Edward DeMartino, Christopher Lee Timmons, John Stephen Peanasky
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Publication number: 20170087059Abstract: A system and method for the dispensing of medication in the form of pills and also to monitor health parameters is disclosed. The system comprises a modular system having a main control module; a plurality of pill dispensing modules in communication with the main control module; and optionally sensors to measure health parameters in communication with the main control module. The main control module can store information and also can communicate information over a communications network.Type: ApplicationFiled: February 23, 2016Publication date: March 30, 2017Applicant: Syntalli, Inc.Inventors: Mark Rodriguez, Carlos Reyes
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Publication number: 20170087060Abstract: A method for repairing a tooth surface having scratches and hollow portions formed on a tooth enamel surface includes administering a tooth surface repairing material to a dental disease patient. The tooth surface repairing material contains a highly crystalline sintered fine calcium phosphate particle having an average particle diameter in the range of 20 to 100 nm.Type: ApplicationFiled: September 8, 2016Publication date: March 30, 2017Applicants: SOFSERA CORPORATION, BRITESMILEJAPAN CO., LTD.Inventors: Kozo TAMAKI, Karl Kazushige KAWABE, Yasumichi KOGAI
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Publication number: 20170087061Abstract: Dental cement compositions (including two-part compositions), kits, and related methods are used for bonding a dental prosthetic appliance to a tooth. A first part includes an amine activator component and a zinc oxide reactive filler, while a second part includes a polymerization initiator (e.g., benzoyl peroxide) and a polymerizable component having a structure including at least one acrylate or methacrylate group at one end and a carboxylic acid group at another end. A temporary cement composition advantageously exhibits reduced compressive and/or bonding strength relative to permanent cement compositions, which provides sufficient strength to facilitate normal use of the teeth while the provisional appliance is in use, while also facilitating easy removal of the provisional appliance for replacement with a permanent appliance at a later time.Type: ApplicationFiled: December 13, 2016Publication date: March 30, 2017Inventors: Gordon Kennard, Andy T. Kawamoto, Jeff Wagner
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Publication number: 20170087062Abstract: Disclosed herein are methacrylate compounds that can be used as components of dental composites. Also disclosed are dental composites comprising the compositions and thiourethane oligomers.Type: ApplicationFiled: March 17, 2015Publication date: March 30, 2017Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Carmem S. Pfeifer, Jack L. Ferracane
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Publication number: 20170087063Abstract: A cleansing composition, a method of making the cleansing composition and a method of using a cleansing composition, the composition including a first liquid surfactant component; a first solid component, including a plurality of cellulose particles; and a first gaseous component.Type: ApplicationFiled: August 30, 2016Publication date: March 30, 2017Inventors: Patricia Bonner, Prithwiraj Maitra, Donald Lynn Harper
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Publication number: 20170087064Abstract: The present invention relates to a composition, preferably a cosmetic composition, comprising: (a) at least one oil; (b) at least one polyglyceryl fatty acid ester, preferably with a polyglyceryl moiety derived from 2 to 6 glycerins; (c) at least one compound selected from the group consisting of resorcinol and resorcinol derivatives; and (d) water. The composition according to the present invention can be in the form of a nano- or micro-emulsion, or can have a lamellar structure or a lamellar phase, with better transparency and stability.Type: ApplicationFiled: June 10, 2015Publication date: March 30, 2017Inventors: Yuichi IKEDA, Maki KOIDE, Anne-Laure BERNARD, Chantal JOUY
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Publication number: 20170087065Abstract: The present invention relates to a composition of pH in the range 2.0 to 4.5 comprising at least one fluoride source and at least one other agent for use in prevention and/or treatment of dental erosion.Type: ApplicationFiled: June 18, 2015Publication date: March 30, 2017Inventors: Thomas BERGLUND, Gunilla JOHANSSON-RUDÉN
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Publication number: 20170087066Abstract: Oral compositions containing a carrier, a cationic antimicrobial compound, and a silica and/or silicate material are disclosed. These compositions can provide a controlled release of the antimicrobial compound.Type: ApplicationFiled: September 26, 2016Publication date: March 30, 2017Inventors: Terry Nassivera, Karl Gallis, Eric Lundquist, Linda Mauller
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Publication number: 20170087067Abstract: A unitary packaged color cosmetic composition having a foundation makeup benefit and a concealer benefit, said composition stored in a receptacle having a closure and applicator, wherein the applicator has a foundation makeup benefit application section and a concealer benefit application section and the section of the applicator used to apply the composition to the keratin surface application area corresponds to the desired benefit.Type: ApplicationFiled: December 12, 2016Publication date: March 30, 2017Inventors: Clara G. Mercado, John F. Logalbo, Aya Shidara, Linda Carol McKenna, Palmer McGuinness, Janet Pardo, Thomas Edward Owen
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Publication number: 20170087068Abstract: Disclosed is a hair care composition comprising: a high melting point fatty compound; a cationic surfactant system; an aqueous carrier; and a propellant; wherein the composition has a foam density of at least about 0.3, and wherein the composition has a foam collapse resistance value of at least about 1.5 kg·m·s?2 [N]. This foaming hair care composition provides improved wet conditioning, spreadability and/or even deposition.Type: ApplicationFiled: September 23, 2016Publication date: March 30, 2017Inventors: Cedric Kofi Aurelien Callens, Stefano Bartolucci, Toshiyuki Iwata
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Publication number: 20170087069Abstract: The present invention relates to a topical composition comprising glycerin, microcrystalline cellulose and/or microcrystalline wax and silica beads having a particle size Dv0 of greater 0.3 ?m, a Dv100 of less than 35 ?m, a Dv50 selected in the range of 9 to 15 ?m and an oil absorption capacity selected in the range of 1.2-2.5 cc/g. Furthermore the invention relates to the use of such beads in combination with microcrystalline cellulose and/or microcrystalline wax to ameliorate the short and long-term sensory properties of a topical composition comprising glycerin.Type: ApplicationFiled: March 24, 2015Publication date: March 30, 2017Inventors: Aline HUEBER, Anne JANSSEN, Christine SAECKER
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Publication number: 20170087070Abstract: The present invention describes specific biocidally effective preservative mixtures and aqueous polymer solutions stabilized with these preservative mixtures and their use in cosmetic preparations, such as skin care and hair care compositions, and hairstyling products and in products for the home care sector.Type: ApplicationFiled: March 13, 2015Publication date: March 30, 2017Inventors: Bernd de Potzolli, Monika Rausch, Karin Juhkason
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Publication number: 20170087071Abstract: A method for increasing and/or synchronizing per1 gene expression in skin cells having decreased, irregular, or asynchronous per1 gene expression comprising treating the skin cells with an effective amount of a polyunsaturated omega-6 fatty acid.Type: ApplicationFiled: September 24, 2015Publication date: March 30, 2017Inventors: Nadine Pernodet, Edward Pelle
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Publication number: 20170087072Abstract: Invention: Citrate primarily constituted with Isotonic Water and Dextrose to stimulate elastin tensile strength below the dermis, below the muscle and above the muscle in order to tighten the skin, decrease the appearance of aging, to contour deficiencies and to contour fine lines and wrinkles. Citrate is found in the serum of individuals but also can be manufactured and processed. Process of manufacturing: Composition: 100 volume percent calculations. 10 volume percent: 0.109 ml 3.2% Sodium Citrate Buffered Citrate molecule: 90 volume percent: 36.6% isotonic water, 0.45% Sodium Chloride and 6.4% Glycerol, trace electrolytes. Sodium citrate powder or in solution is placed into a 20 cc intravenous vial for dispensing. Within the packaging an 8 to 10 cc syringe of a liquid volume which includes the following four items: Isotonic Water, Sodium Citrate and Glycerol is given to inject as reconstitution. The injector mixes the ingredients back and forth between two 10 cc syringes.Type: ApplicationFiled: September 29, 2015Publication date: March 30, 2017Inventor: Vivi Robyn Stafford
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Publication number: 20170087073Abstract: This invention relates to a composition that is mild to the skin containing a cosmetically acceptable oil; water; a cosmetically acceptable emulsifier having an HLB of from about 1 to about 25; and a preservative comprising an organic acid selected from the group consisting of benzoic acid, p-anisic acid, sorbic acid, lactic acid, acetic acid, formic acid, oxalic acid, tartaric acid, salicylic acid and citric acid; wherein said composition has a pH less than 5 and a buffer capacity of between about 0.Type: ApplicationFiled: December 13, 2016Publication date: March 30, 2017Inventors: Euen T. Gunn, Patricia Bonner, Delores Santora
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Publication number: 20170087074Abstract: The invention relates to a surfactant composition including at least one compound of formula (I): in which each of the radicals Z is a hydrogen atom or (Z1); at least one compound of formula (IV); one compound of formula (V); and one compound of formula (VI). The invention also relates to a method for preparing said composition and to the use thereof in cosmetics.Type: ApplicationFiled: November 26, 2014Publication date: March 30, 2017Inventors: Dimitri PERUSSE, Thierry BENVEGNU, Loïc LEMIEGRE, Jêrome GUILBOT, Hervé ROLLAND
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Publication number: 20170087075Abstract: The invention relates to a composition comprising: i) at least one oxidation base, preferably of heterocyclic and/or para-phenylenediamine type; and ii) at least one heteroaryl coupler of formula (I), with R1, R2, R3, A and X as defined in the description. The invention also relates to a process for dyeing keratin fibres using ingredients i) and ii); to a kit comprising ingredients i) and ii); and to the use of ingredient i) combined with ii) for dyeing keratin fibres. The composition of the invention leads to particularly powerful, chromatic and sparingly selective colourings.Type: ApplicationFiled: May 13, 2015Publication date: March 30, 2017Inventors: Alain LAGRANGE, Boris LALLEMAN
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Publication number: 20170087076Abstract: The present invention relates in general to keratin treatment compositions and methods, and more specifically, compositions comprising up to 60% olefinic compounds and at least one unactivated double bond, the composition comprising fatty acid esters of polyhydric alcohols. The present invention is configured to be easily incorporated into bleaching processes, coloring processes, perming processes, shampoos, conditioners and/or styling products. The purpose of the invention is to provide a composition and method that will improve the overall health of keratins, in particular, texture, body, shine and strength.Type: ApplicationFiled: September 30, 2016Publication date: March 30, 2017Inventors: Joseph I. Kravitz, Sara M. Dreamer, Angelia J. Francis, Steve M. Hudson, Thomas D. Boatright
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Publication number: 20170087077Abstract: The invention relates to a composition (C1) including: (a) at least one compound of formula (I) in which each of the radicals Z is a hydrogen atom or a monovalent radical (Z1); (b) at least one compound of formula (IV); (c) a compound of formula (V). The invention also relates to a method for preparing said composition and to the use thereof in cosmetics.Type: ApplicationFiled: November 26, 2014Publication date: March 30, 2017Inventors: Dimitri PERUSSE, Thierry BENVEGNU, Jêrome GUILBOT, Hervé ROLLAND
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Publication number: 20170087078Abstract: The present invention provides a cosmetic composition containing (A) 3-O-alkyl-L-ascorbic acid wherein the alkyl group has 8-12 carbon atoms or a salt thereof, (B) one or more kinds of nonionic surfactants selected from the group consisting of polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether and polyoxyethylene alkenyl ether, and having an HLB value of 12.5-17, and (C) one or more kinds of oil agents selected from the group consisting of amino acid ester, dimer acid ester, hydroxy acid ester, alkyl glyceryl ether and alkenyl glyceryl ether, which is superior in solubilization stability, preservation stability and sense of use, and free of time-dependent development of an odor which poses a problem when in use.Type: ApplicationFiled: December 9, 2016Publication date: March 30, 2017Applicant: AJINOMOTO CO., INC.Inventor: Mandai YAMADA
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Publication number: 20170087079Abstract: A tooth whitening product is provided. The tooth whitening product has a backing layer and a tooth whitening composition.Type: ApplicationFiled: December 13, 2016Publication date: March 30, 2017Inventors: Paul Albert Sagel, Lan Ngoc Nguyen, Randy Purnell Washington
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Publication number: 20170087080Abstract: The present invention relates to a cosmetic composition for making up and/or caring for the lips, which is in the form of a liquid emulsion including: a) at least 5% by weight, relative to the total weight of the composition, of one or more non-volatile oils; b) 1 to 30% by weight of active substance, relative to the total weight of the composition, of at least one film-forming agent chosen from vinyl polymers comprising at least one carbosiloxane dendrimer-based unit; c) at least 10% by weight of water relative to the total weight of the composition, d) least one coloring material.Type: ApplicationFiled: December 5, 2016Publication date: March 30, 2017Applicant: L'OREALInventors: Florence LAHOUSSE, Emilie Henin
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Publication number: 20170087081Abstract: The present invention relates to a cosmetic composition for skin moisturization that contains minerals and a quinoa extract.Type: ApplicationFiled: March 26, 2015Publication date: March 30, 2017Applicant: Amorepacific CorporationInventors: Jin Young LEE, Sung Hoon LEE, Lee Kyoung KWON, Byung Ryol PAIK, Hae Kwang LEE
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Publication number: 20170087082Abstract: The invention relates to a cosmetic composition for bleaching the skin, which includes a) at least one oily plant extract from the Glycyrrhiza genus and b) at least one ascorbic acid ester. The invention further relates to the cosmetic, nontherapeutic use of the cosmetic composition according to the invention to treat excessive pigmentation, pigmentation disorders, age spots, and/or post-inflammatory hyperpigmentation of the skin, and to a method for producing a cosmetic skin-bleaching composition in the form of an O/W or a W/O emulsion, wherein an oily extract from licorice roots is dissolved in the water phase by the addition of an ascorbic acid ester.Type: ApplicationFiled: December 9, 2016Publication date: March 30, 2017Applicant: Henkel AG & Co. KGaAInventors: Thomas Doering, Natascha Schevardo, Melanie Giesen
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Publication number: 20170087083Abstract: A composition that includes spray-dried yoghurt powder and at least one anionic surfactant and/or at least one fatty acid soap, may be used as a prebiotic for inhibiting the growth and/or the physiological activity of undesired skin bacteria and/or for obtaining desired skin bacteria. A prebiotically effective cosmetic composition includes: a) at least one fatty acid soap in a weight proportion of between 20 and 75 wt. %, preferably between 30 and 70 wt. %, particularly preferably between 40 and 65 wt. %, and in particular between 45 and 60 wt. %; and b) spray-dried yoghurt powder in a weight proportion of between 0.01 and 10 wt. %, preferably 0.02 and 7.5 wt. %, particularly preferably between 0.03 and 5 wt. %, and in particular between 0.05 and 3 wt. %, wherein the amounts relate to the total weight of the cosmetic composition.Type: ApplicationFiled: December 12, 2016Publication date: March 30, 2017Applicant: Henkel AG & Co. KGaAInventors: Heike Schelges, Elvira Scholz, Stefanie Schmitz, Kirsten Sartingen, Evelyn Domfeld, Barbara Heide
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Publication number: 20170087084Abstract: Dissolvable unit dose constructs and their method of manufacture are disclosed in which the unit dose constructs are formed of a composition including a polymer matrix that includes a water soluble polymer, active ingredient, and a liquid carrier. The composition is deposited directly, such as by stenciling, to form individual unit doses without the need to cut and convert long, continuous rolls of film.Type: ApplicationFiled: December 7, 2016Publication date: March 30, 2017Inventors: Matthew K. MUSHO, John H. LIND, Scott D. BARNHART
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Publication number: 20170087085Abstract: Methods and products for treating or preventing erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical aqueous gel composition comprising about 0.01% to about 10% by weight of at least one ?-adrenergic receptor agonist and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Jack A. DEJOVIN, Isabelle Jean DEJOVIN, Yin-sang LIU, Matthew James LEONI
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Publication number: 20170087086Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.Type: ApplicationFiled: September 15, 2016Publication date: March 30, 2017Applicant: DURECT CORPORATIONInventors: Guohua Chen, David T. Priebe
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Publication number: 20170087087Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.Type: ApplicationFiled: September 28, 2016Publication date: March 30, 2017Applicant: Northwestern UniversityInventors: Joshua N. Leonard, Michelle E. Hung
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Publication number: 20170087088Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis, among others. Methods generally involve administering provided compositions to the skin.Type: ApplicationFiled: December 14, 2016Publication date: March 30, 2017Inventors: Jonathan Edelson, Timothy Kotyla, Klaus Theobald
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Publication number: 20170087089Abstract: The present invention relates to a process for the preparation of unilamellar liposomal composition of a polyene antibiotic drug. The present invention further relates to liposomal composition of a polyene antibiotic drug that is stable.Type: ApplicationFiled: September 30, 2016Publication date: March 30, 2017Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTDInventors: Sachin Pushkarray Naik, Ujjawal Jayantilal Seju, Subhas Balaram Bhowmick
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Publication number: 20170087090Abstract: A vehicle to carry a powered medication that addresses the limitations of the prior art. It includes a system and method. A powder delivery system includes a first panel and a second panel coupled together around a periphery of the panels to form a sealed void therebetween, each the panel having a width and length about equal to a standard credit card width and length, respectively; and a powder, disposed in the void, having a quantity at least about equal to an active dose of the powder, wherein a thickness of the panels with the powder disposed therebetween is not greater than about 0.1 inches and more preferably not greater than about 0.03 inches.Type: ApplicationFiled: December 14, 2016Publication date: March 30, 2017Inventor: Jordan Eisenberg
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Publication number: 20170087091Abstract: The invention provides for the use of an accordion pill comprising levodopa for the treatment of symptoms of Parkinson's disease in a subject in need thereof over a 24 hour period, to be administered to the subject in a twice daily administration regimen, with an interval of about 8 to about I 0 hours between the first dose and the second dose, and with an interval of about 14 to about 16 hours between the second dose and the first dose of the following day. The twice daily administration regimen provides a stable blood plasma level of levodopa in the subject after multiple administrations and is effective in treating the symptoms of Parkinson's disease over a 24 hour period.Type: ApplicationFiled: February 3, 2016Publication date: March 30, 2017Inventors: Nadav Navon, David Kirmayer, Julia Shvetz, Elena Kluev, Eva Abramov, Zeev Weiss, Giora Carni
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Publication number: 20170087092Abstract: A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells.Type: ApplicationFiled: December 14, 2016Publication date: March 30, 2017Applicant: Capsugel Belgium NVInventors: Dominique Nicolas Cade, David He Xiongwei
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Publication number: 20170087093Abstract: Provided is a pharmaceutical composition comprising clevidipine in a sterile, ready to use, physically stable, aqueous dispersion of nanoparticles that stabilizes clevidipine against formation of impurities and is suitable for parenteral administration.Type: ApplicationFiled: May 19, 2015Publication date: March 30, 2017Applicant: Chiesi Farmaceutici S.p.A.Inventors: Rajeshwar Motheram, David C. Hanley, Sr., Akif Emre Tureli, Monika Kanter
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Publication number: 20170087094Abstract: Nanostructures, compositions and methods for treating vesicle-related or exosome-related conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers, neurological disorders, rheumatologic disorders, viral disorders or other diseases or conditions at least in part by regulating vesicle uptake. Methods of analyzing, imaging and modulating vesicles and cellular vesicles processes are also provided.Type: ApplicationFiled: October 31, 2016Publication date: March 30, 2017Applicant: Northwestern UniversityInventors: Michael P. Plebanek, C. Shad Thaxton, Raja Kannan Mutharasan, Nicholas L. Angeloni, Kaylin M. McMahon