Abstract: A surgical positioning system includes a flexible air-impermeable shell filled with beads that is wrapped against the patient and subjected to a vacuum to hold the patient in place. An air-impermeable top wall can be joined with an air-impermeable bottom wall to define a plurality of chambers. Each of the chambers can include a peripheral edge that extends around the periphery of the respective chamber. The plurality of chambers can include a first shoulder chamber, a second shoulder chamber, and a main chamber.

Abstract: A locking fastener may include a head and a shaft with a pin interface configured to engage a pin for locking the locking fastener in place. Such locking fasteners may be used to connect a plurality of casket components, and are especially useful for wooden caskets. Methods of making such locking fasteners using a fastener finishing device are also described herein.

Abstract: A method for mobilizing a hip joint capsule of a patient using a resilient bolster. In accordance with the method, the patient assumes a lateral position, with the hip capsule to be treated superior. The resilient bolster is placed between the patient's legs as proximal to the patient's crotch. A force is applied to patient's superior leg to move it downwardly from a resting position. During downward movement of the patient's superior leg, the bolster functions as a fulcrum and the patient's superior femur functions as a lever arm to create a first class lever that partially distracts the femoral head from the acetabulum. After application of the force, the resiliency of the bolster causes the patient's superior leg to return to the resting position. The movements may be repeated, and the degree of hip flexion and rotation may be varied to affect different regions of the hip capsule.

Abstract: The present invention relates to a two-degree-of-freedom planar rehabilitating, monitoring and/or evaluating device comprising a first guiding mechanism (2), a second guiding mechanism (3), substantially parallel to the first guiding mechanism (2), a third guiding mechanism (4), substantially perpendicular to the first and second guiding mechanisms (2, 3), and an end-effector (5), wherein the third guiding mechanism (4) is connected to the first and second guiding mechanisms (2, 3), and wherein the end-effector (5) is connected to the third guiding mechanism (4). The present invention also relates to a two-degree-of-freedom planar rehabilitating, monitoring and/or evaluating interactive device adapted for rehabilitation, monitoring and/or assessment of the upper limbs of a subject, comprising said device.

Abstract: A compression device can treat edema with a plurality of shell structures, each having an inside pad. A ligature network is routed across the shell structures. A plurality of tensioners mounted on at least some of the plurality of shells can separately adjust tension in different portions of the ligature network to affect the balance of compression forces at spaced positions along the plurality of padded shells. At least some of the shell structures have an underpass sized to accommodate passage of a portion of the ligature network. The underpass is integral with a corresponding one of the plurality of shell structures. In one case the shells include an interconnected plurality of volar shells placed on one side of a body part and a dorsal shell on the opposite side.

Abstract: A compression garment system and method that may include a head garment portion configured to be donned on a head of a body. The compression garment and method may further include a neck garment portion configured to be donned on a neck of the body. A controller may be configured to control pressure applied by each of one or more head pressure applying regions and/or each of one or more neck pressure applying regions to move lymph at least from the head towards the neck.

Abstract: Compression systems and methods may include a garment configured to be donned on, for example, a head and a neck of a body. For example, the garment may include a static garment portion configurable to apply a static pressure to a portion of the head and a dynamic garment portion including one or more pressure applying regions controllable to apply pressure to the head and neck. Further, a controller may be configured to control pressure applied by the one or more pressure applying regions.

Abstract: Compression garments and methods may include a head garment configured to be positioned around both sides of a head of a body from a posterior of the head to an anterior of the head (e.g., wherein the head garment may include a plurality of controllable head pressure applying regions positionable proximate at least cheeks and a posterior of the head) and a neck garment (e.g., coupled to the head garment). The compression garments and methods may also include a torso garment. Such garment portions may include one or more controllable pressure applying regions to move lymph from the head downward.

Abstract: Compression garments may include mitts and tightening apparatus to don, or put on, such compression garments. The mitts may be configured to receive a user's hand such that the user can move one or more portions of the garments using the mitts. The tightening apparatus may allow a user to selectively tighten or loosen the garments about the user's body portions. Once donned, the compression garments may apply pressure to one or more regions of the user's body such as, e.g., arm regions, shoulder regions, torso regions, and neck regions.

Abstract: A wand system includes a plurality of wand portions, each wand portion having at least one dimension that differs from the other wand portions, and a handle portion that defines an aperture through the handle portion. Each of the plurality of wand portions is configured to removably engage the handle portion to define a wand assembly.

Abstract: A rejuvenation and massage device is provided for treating mucosa tissue, such as vaginal tissue, affected by Vaginal Relaxation Syndrome (VRS) or other conditions, through vibration, thermal loading, and light emittance for a duration of time. In one embodiment, the device is an insertable device that includes Low-Level Laser Light (LLLT) therapy to treat the vaginal tissue. The light emittance by one or more light emitters is in a range sufficient to provide therapeutic effects through light radiation. To enhance the therapeutic effects of light radiation provided by the device, the device is configured to provide increased energy density into target tissue of vaginal muscles though a light configuration component (e.g., a focusing component, such as a concave lens assembly, a convex assembly, a pre-lensed light emitter or other focusing optical mechanism) associated with the light emitter that concentrates the light emitted from the light emitter.

Abstract: A vibratory massaging device having a spaced plurality of proximity sensors distributed on a massaging surface of the device, and a control circuit operative for controlling vibratory intensities in response to activation of particular ones of the sensors being close to a user's body parts being massaged. The device can be configured as a dildo, including both main and secondary vibrators, the secondary vibrator being within an arm portion that is configured for clitoral stimulation. At least one of the vibrators is automatically driven at increased intensity as penetration increases.

Abstract: In some embodiments, a method may include clearing a biological airway. The method may include positioning an inner wearable harness on a torso of a subject. The method may include selectively positioning at least some of a plurality of engines on and/or adjacent at least one treatment area. At least one of the plurality of engines may be releasably couplable to the inner wearable harness. The method may include positioning an outer wearable harness on a torso of a subject. The method may include applying an oscillation force to at least one of the treatment areas using at least some of the plurality of engines. The method may include adjusting the applied oscillation force to the treatment area by activating the outer wearable harness. The method may include mobilizing at least some secretions in an airway within the subject substantially adjacent the at least one treatment area.

Abstract: A device for providing guidelines for cardiopulmonary resuscitation (CPR) includes an input unit operable to receive a gender information of a CPR provider; a. processing unit operable to process the gender information of the CPR provider; and an output unit operable to provide an output. If the gender information of the CPR provider is male, the output unit provides an instruction to the CPR provider to place an end of heel of his hand over a distal end of a sternum during chest compressions. In addition, if the gender information of the CPR provider is female, the output unit provides another instruction to the CPR provider to place an end of heel of her hand approximately 1.5˜2.0 cm above a distal end of a sternum during chest. compressions.

Abstract: A lightweight, height-adjustable, moveable feet-massage grabbing bar rack erectable at a desired location to administer ahiatsu to patients. The rack includes first and second side stands positional on either side of a patient. A grabbing bar assembly is securable spanning between the first and second side stands to rigidly maintain the rack upright and supportively uphold a massager engaging each of a pair of parallel bars underarm while administering ahiatsu alongside a patient's back. The grabbing bar assembly is securable between a range of positions to accommodate particular heights appropriate to the needs of particular patients, massage locations, and massagers. The rack is readily disassembled for portage when desired.

Abstract: A packaging system is provided for securely and irreversibly holding a sterile product. The packaging system includes a primary packaging holder and a secondary packaging holder. The secondary packaging holder has a body made up of a top having a receiving portion configured to receive the primary packaging holder, a base having a plurality of apertures and a first and second planar wall extending from opposing ends of the base in parallel to opposing ends of the top. The secondary packaging holder also has a first and second plate configured to secure opposing ends of an opening though the body. The first plate comprises a first securing feature, and the second plate comprises a second securing feature. The first and second securing features are capable of jointly securing and irreversibly holding the primary packaging holder in the secondary packaging holder.

Abstract: According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

Abstract: Various embodiments relate to systems and methods for monitoring adherence to a medication regimen through the use of a smart medication container. The container can include an electronic display that presents relevant information, such as dosage and/or medication information, instructions, user information, messages, notifications, and device information (e.g., battery status, network connectivity status). A pair of conductive elements positioned on either side of the container's opening can be configured to continually measure capacitance in order to identify when contents (e.g., pills) leave the container. More than one pair of conductive elements may be used to improve accuracy and reduce the effects of noise. A processor is able to analyze the capacitance data and determine whether medication has been dispensed from the container and, if so, how much medication was dispensed. A computer system can then compare the results to a planned medication regimen to determine a state of compliance.

Abstract: A child's oral comfort device such as a teether or pacifier includes a strap, such as a wrist band, a housing removably attached to the strap, and a mouth portion fixed to the housing. The housing has a base and a removable cap. Inside the base of the housing is a printed circuit board having a sensor, a timer, a vibrator motor, a power source and a controller. When the infant applies pressure to the mouth portion, the sensor responds and sends a signal to the controller that activates the vibrator to vibrate the mouth portion for a predetermined time. The controller then prevents the vibrator from vibrating until the child reactivates the device with more pressure to start the vibrating cycle again. When the removable cap is attached, the housing and mouth portion are sealed preventing liquid from coming into contact with printed circuit board or its components. The strap, housing and mouth portion are constructed of silicone.

Abstract: Provided are a silicon oxide-coated zinc oxide, a method for producing the same, a composition and a cosmetic including a silicon oxide-coated zinc oxide. The silicon oxide-coated zinc oxide is a silicon oxide-coated zinc oxide formed by coating surfaces of zinc oxide particles with a silicon oxide coat, in which an average particle diameter of the zinc oxide particles is in a range of more than 50 nm and 500 nm or less, and, when an abundance ratio of silicon in the silicon oxide coat in a Q3 environment is indicated by Q3, and an abundance ratio in a Q4 environment is indicated by Q4, Q3+Q4?0.6 and Q4/(Q3+Q4)?0.5 are satisfied.

Abstract: A hair fiber treating method not containing a fixing step, comprising, applying to the hair fibers at least one reducing composition, free of ceramide, comprising at least one reducing agent; and raising the temperature of the hair fibers using a heating iron at temperature of at least 60° C., wherein the temperature of the hair fibers are raised before or after the hair fiber are optionally rinsed.

Abstract: This disclosure relates to hair styling compositions and processes, and more particularly to compositions for disentangling or crosslinking hair that are useful in hair styling processes.

Abstract: The present invention relates to a composition containing in an aqueous medium, at least 1) a sulfonate mixture containing: a) an internal olefin sulfonate (A) having 16 carbon atoms and b) an internal olefin sulfonate (B) having 18 carbon atoms,—wherein the weight ratio (A/B) of the component (A) to the component (B) present in the sulfonate mixture is from 75/25 to 90/10, preferably from 80/20 to 85/15, and—wherein the weight ratio of the hydroxy form compounds present in the internal olefin sulfonates (A) and (B) to the olefin form compounds present in the internal olefin sulfonates (A) and (B) is from 75/25 to 100/0, preferably from 80/20 to 95/5; and 2) at least one foam-enhancing agent or foam booster. The present invention relates also to a process for cleansing keratin materials, which consists of applying to the said keratin materials a composition according to the invention, in working the said composition into a foam and then rinsing off the said composition, especially with water.

Abstract: An aqueous shear-thinning personal care composition comprises: (a) at least 3 wt % of a sulfonate compound of general formula (I): where R1 represents a C8-22 alkyl group alkyl group; R2 represents a C1-4 alkyl group; each of R3, R4 and R5 independently represents a hydrogen atom or a C1-4 alkyl group; and M+ represents a sodium or potassium cation; (b) at least 3 wt % of an amphoteric or zwitterionic surfactant; (c) at least 10 wt % of water; and (d) at least 0.5 wt % of an additional component in the form of particles or droplets suspended in the composition. The composition is stable in an aqueous environment and can be formulated with a wide range of additional components.

Abstract: Disclosed is a cosmetic or dermatological preparation which comprises glycyrrhetic acid and/or glycyrrhizin and further comprises at least one substance selected from UV filter substances, self-tanning agents and antioxidants.

Abstract: The invention relates to a cosmetic process for caring for the skin, more particularly facial skin, in particular wrinkled skin, comprising: either the topical application to the skin of an extemporaneous mixture of a cosmetic composition comprising a hyaluronic acid polymer grafted with (meth)acrylate groups and an amine compound; or the sequential application to the skin of a cosmetic composition comprising a hyaluronic acid polymer grafted with (meth)acrylate groups and of an amine compound having one or more primary amine and/or secondary amine groups. The invention also relates to the use of said grafted hyaluronic acid polymer and of said amine compound as a skin tensioning agent. The invention also relates to a cosmetic composition obtained by mixing a cosmetic composition comprising said grafted hyaluronic acid polymer and said amine compound.

Abstract: An improved composition of hair oil for stimulation of hair growth, control of hair fall, dandruff and infections thereof. The composition of hair oil comprising active ingredients of Capric Caprylic Tri-Glycerides (CCTG), Mineral oil, Coconut Oil, Ylang Ylang Oil, Di-propylene Glycol, Centella Asiatica Extract and Butylated Hydroxy Toulene. The composition of hair oil supports the hair growth and relaxation of the scalp. The composition of hair oil also effectively reduces/remove dandruff and thereby control hair fall in the subject (e.g., not limiting to male/female human). The composition of hair oil additionally demonstrates the properties of cooling effect, darkening of hair and promotion of hair upon continuous use of the hair oil by the subjects. The proposed composition is alternatively used to reduce/remove Psoriasis.

Abstract: An extemporaneous product for the preparation of dermatological and/or cosmetic compositions, the product including, on the one hand, one or several active substances and on the other, a universal base allowing such active substance or substances to be solubilised and including at least one oil rich in omega-3, water, glycerine, an alcohol other than glycerine, and emulsifier and a biomimetic peptide.

Abstract: A method for preparing a bioactive composition containing conditioned cell culture medium is disclosed. The method comprises culturing cells of two or more eukaryotic cell line to form conditioned culture media, separating the cultured cells from the conditioned culture media, and combining conditioned culture media to form a bioactive composition. Novel bioactive compositions, formulations and their use in treating of a variety of diseases and health conditions are also disclosed.

Abstract: Micro implement with micro payload is used for painless and safe percutaneous drug delivery. The micro•head made of maltose or saccharide contains drug and stands on micro-stem installed in orifice of stem holder. Non drug micro-stem supports the payload to adjust insertion depth and reach an interest region under skin and is set to come out from the orifice just after insertion. The payload is completely bullet-like inserted into skin and the drug contained micro•head in the upper micro payload is also delivered into skin completely. The bioavailability 100% is accomplished. The inserted payload solves in internal water and releases drug around the interest region. The implement is composed of payload and holder. The payload is unified of micro•head with drug and non-drug micro•stem. All saccharides means ecologically disposable.

Abstract: A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide transfer of molecules to or from the storage chamber, and a plurality of impellers attached to the containment vessel. The plurality of impellers are of a structure and are arranged to substantially block molecules from entering and exiting the storage chamber of the containment vessel when the impellers are static and are operable to impart motion to the molecules to cause the molecules to at least one of enter into or exit from the storage chamber of the containment vessel.

Abstract: A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder.

Abstract: A method for producing a composition of lipidic particles coated with a cross-linked surface mesh, the method comprising the steps of: (i) preparing lipidic particles comprising pharmaceutically acceptable lipids, (ii) binding hydrophilic polymer chains to the surface of the lipidic particles, and (iii) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh. Pharmaceutical compositions comprising surface modified lipidic particles prepared according to this method are also described. The lipidic particles resist fusion with red blood cells and platelets in vitro, and are amenable to further derivatization by targeting molecules for controlled release of component and contents, thus providing a new generation of drug carrier systems.

Abstract: A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.

Abstract: The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

Abstract: The present invention relates inter alia to the use of selectively moisture-adjusted tabletting material in the preparation of mechanically stable oral tablets which contain at least one hydrate-forming active substance and/or adjuvant relevant to the mechanical stability of the tablets, particularly arginine-containing oral tablets.

Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and/or a SGLT-2 inhibitor drug, and metformin XR, processes for the preparation thereof, and their use to treat certain diseases.

Abstract: The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channel guides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

Abstract: A novel gelatin comprising dosage form article for oral administration and for containing therein a fill composition, the fill composition comprising one or more active materials capable of reacting with gelatin, and optionally one or more excipient materials, wherein the dosage form is made of a gelatin material and one or more plasticizers, the gelatin material having a mean molecular weight of less than about 130,000 g/mol and a low microgel content, wherein the fraction of microgel is of less than about 10% of the total number of gelatin chains of said gelatin material.

Abstract: Provided are a transdermal absorption sheet capable of suppressing a sheet portion from being curled and of improving impact resistance of the sheet portion, and a method of manufacturing the transdermal absorption sheet, capable of suppressing a sheet portion from being curled in drying and of shortening a time required for drying a base material liquid. A transdermal absorption sheet includes: a sheet portion; a plurality of needle-like protruding portions that are arranged on one surface of the sheet portion; and a sheet-like mesh structure body that is included in the sheet portion and that has an area, in a plan view, including at least a part of a region in which the plurality of needle-like protruding portions are arranged.

Abstract: An impaired glucose tolerance ameliorative agent containing a peak component of partition chromatography of an gramineous plant seeds alcohol extract. The peak component preferably contains an alkylresorcinol (AR) mixture containing a plurality of alkylresorcinols (ARs). The AR mixture preferably contains (1) an AR of general formula (I) wherein R1 is a C15 saturated or unsaturated alkyl group, (2) an AR of formula (I) wherein R1 is a C17 saturated or unsaturated alkyl group, (3) an AR formula (I) wherein R1 is a C19 saturated or unsaturated alkyl group, (4) an AR of formula (I) wherein R1 is a C21 saturated or unsaturated alkyl group, (5) an AR of formula (I) wherein R1 is a C23 saturated or unsaturated alkyl group , and (6) an AR of formula (I) wherein R1 is a C25 saturated or unsaturated alkyl group. R1 is C15-C25 saturated or unsaturated alkyl. R2 is hydrogen or methyl.

Abstract: Disclosed are compositions and methods for the treatment of a subject having an autism spectrum disorder. The disclosed compositions may contain racemic ketamine or S-ketamine. The disclosed methods of administering the compositions include intranasal administration to a subject having an autism spectrum disorder.

Abstract: The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo.

Abstract: Compositions and methods to produce adhesive articles with active agents concentrated at the substrate contacting surface. The active agents are applied in powder form, or in combination with a liquid or gel vehicle, to the substrate contacting surface of an adhesive layer of an adhesive article. The active agent compositions are directly applied to the adhesive layer, or are first applied to a release liner, which is then brought into contact with the adhesive layer to dispose the active agent compositions to the substrate contacting surface of the adhesive layer. Upon application of the adhesive article to a substrate, the active agent is delivered to a region of interest on the substrate.

Abstract: Provided are ion complexes comprising treprostinil and an ion-exchange resin, pharmaceutical formulations based on such complexes, and methods of treating diseases and conditions using the ion complexes and pharmaceutical formulations.

Abstract: Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

Abstract: The present invention concerns a pharmaceutical composition comprising 0.3% by weight of adapalene or a pharmaceutically acceptable salt thereof and 2.5% by weight of benzoyl peroxide, as active ingredients, for its use by topical administration in the treatment of inflammatory acne lesions. The present invention further concerns regimen for the therapeutic treatment of acne lesions in subjects afflicted with severe acne. The regimen includes topically applying to a subject's skin, as active ingredients, 0.3% by weight adapalene and 2.5% by weight benzoyl peroxide, combined in a single formula that delivers the active ingredients together. The single formula can for example be applied once or twice daily for a period of 8 to 12 weeks.

Abstract: The invention relates to medicine, and more particularly to psychopharmacology, and is directed to an agent for treating and preventing autism spectrum disorders; said agent is glycine immobilized on detonation nanodiamond particles 2-10 nm in size, wherein the content of glycine is from 1 to 21±3 wt. %. The described agent improves the outcome of drug therapy and preventive treatment of autism in children and adults and expands the range of the effective and safe psychotropic medications.

Abstract: A method is provided for treating a Mendelian disorder of the epigenetic machinery in a subject in need thereof. In particular, the method comprises administering a therapeutically effective amount of an agent that restores balance between open and closed chromatin states at one or more target genes, wherein the agent that restores balance between open and closed chromatin states at one or more target genes is an agent that ameliorates the effect of a defective gene encoding a component of the epigenetic machinery.

Abstract: Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating diseases, including focal segmental glomerulosclerosis or pulmonary arterial hypertension. The compositions of such embodiments include activated fatty acids such as alkyl substituted fatty acids, keto fatty acids and nitro fatty acids. The methods of various embodiments include administering an effective amount of 10-nitro-9(E)-octadec-9-enoic acid to treat such diseases.