Abstract: Disposable absorbent articles assembled from a collection of components using an adhesive comprising an amorphous polyolefin composition and a heterophase polyolefin composition comprising amorphous character and crystalline blocks.

Abstract: This invention relates to a wound dressing, particularly to a stimuli responsive wound dressing comprising a lyophilized hyaluronic acid (HA) hydrogel, and a plurality of devices embedded within said lyophilized hyaluronic acid hydrogel. Each of the plurality of devices including chitosan and hypromellose and may be formed as biofilms and/or electrospun fiber mats.

Abstract: Embodiments of the present disclosure provide for structures including an alloy of calcium, strontium, and magnesium.

Abstract: The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 ?m thick with pores smaller than 25 ?m. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

Abstract: Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

Abstract: The present invention discloses adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF), their compositions and kits containing the ADSC's and their enriched fractions, and enzyme blends useful for their isolation, as well as methods of their isolation and use.

Abstract: A method of reducing phospholipid concentration in biological tissue. The biological tissue is immersed in an isopropyl alcohol solution for an effective period of time. After the effective period of time, the biological tissue has a phospholipid concentration that is at least 10 percent by weight less than an initial phospholipid concentration of the biological tissue.

Abstract: An object of the present invention is to provide a cell structure for brain damage treatment which does not contain glutaraldehyde and in which it is possible to exhibit a sufficient effect of treating brain damage, a production method thereof, and a brain damage treatment agent. According to the present invention, there is provided a cell structure for brain damage treatment which contains biocompatible macromolecular blocks and at least one kind of cell and in which a plurality of the biocompatible macromolecular blocks are disposed in gaps between a plurality of the cells, in which the tap density of the biocompatible macromolecular block is 10 mg/cm3 to 500 mg/cm3 or a value obtained by dividing a square root of a cross-sectional area in a two-dimensional cross-sectional image of the biocompatible macromolecular block by a peripheral length is 0.01 to 0.13.

Abstract: An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a selective laser sintering process or a selective laser melting process or a selective heat sintering process or an electron beam melting process. The antibiotic-eluting article may be temporary or permanent orthopaedic skeletal component, an orthopaedic articulating joint replacement component, and/or an external hard-shell casing for an implantable device. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material. The implantable device may be a cardiac pacemaker, a spinal cord stimulator, a neurostimulation system, an intrathecal drug pump for delivery of medicants into the spinal fluid, and infusion pump for delivery of chemotherapeutics and/or anti-spasmodics, an insulin pump, an osmotic pump, and a heparin pump.

Abstract: A heat shrink tubing, which can be readily peeled in the longitudinal direction after use (e.g., to remove the heat shrink tubing from an underlying material) is provided herein. The heat shrink tubing can be of various compositions, and generally is produced from at least one fluorinated, copolymeric resin. The tubing can exhibit desirable physical properties such as good optical clarity (e.g., translucency or transparency) and/or peelability, exhibiting one or more of complete, straight, and even peeling along a given length of tubing.

Abstract: A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid collector for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid collector. The vacuum connection may be separated from the liquid collector by a liquid barrier.

Abstract: An inhalation device includes a nozzle, a separator, a housing, a battery portion, a circuit board, and a piezoelectric blower. The piezoelectric blower has a suction hole that opens near the center of an upper surface of the piezoelectric blower and a discharge hole that opens at the center of a bottom surface of the piezoelectric blower. The piezoelectric blower is mounted on a first main surface of the circuit board on the side of an upper housing. The circuit board applies a drive voltage to the piezoelectric blower to drive the piezoelectric blower. The circuit board has a through-hole facing the discharge hole. The through-hole overlaps the discharge hole, out of the suction hole and the discharge hole, when the first main surface of the circuit board is viewed from a front side.

Abstract: An adapter system for facilitating collection of colostrum from a breast may include an adapter, a removable reservoir and a hand-expression funnel. The adapter may include a first open end for connecting to a breast shield of a breast pump system, a second open end for connecting to a breast pump connector of the breast pump system, and a third open end, disposed between the first and second open ends. The removable reservoir may include a wide end for removably attaching to the third open end and a narrow end for attaching to a colostrum delivery device. The hand-expression funnel may include a wide end for receiving colostrum and a narrow end for attaching to the colostrum delivery device. In some embodiments, the colostrum delivery device is a syringe.

Abstract: A system for supporting the blood gas exchange by means of mechanical ventilation and extracorporeal blood gas exchange comprises a ventilation device for mechanical ventilation of the lungs of a patient, and an ECLS device for the extracorporeal blood gas exchange, wherein the ventilation system is designed to perform mechanical respiratory support by the ventilation device on the one hand and an extracorporeal blood gas exchange by the ECLS device on the other hand in coordinated, automated manner in order to support the gas exchange in the blood circulation of the patient, wherein the ECLS device sets a level of the extracorporeal blood gas exchange, and the ventilation device, on the basis of the level of the extracorporeal blood gas exchange set by the ECLS device, adjusts in automated manner to a level of the mechanical respiratory support.

Abstract: A blood purification apparatus is provided that can easily and accurately determine before treatment whether or not blocking of liquid by a check valve is appropriate.

Abstract: Provided is a multi-functional filter including a first filter and a second filter to purify a biological fluid, a housing defining an adsorption section outside of the first filter and the second filter, a flow partitioning connector connecting the first filter and the second filter, and a housing port allowing a fluid to flow through the adsorption section. The housing may comprise a wall, a first cap coupled to the first filter at one end of the wall along a longitudinal direction, and a second cap coupled to the second filter at the other end of the wall along a longitudinal direction. The multi-functional filter according to the present invention in which dialysis, adsorption, and plasma separation or ultrafiltration are integrated to purify blood or dialysate and the internal flow is facilitated may provide a blood purifying apparatus that simplifies the whole apparatus, provides convenience in installation and use, and reduces a treatment cost.

Abstract: Provided is a dialysate supply device and a blood dialyzing apparatus including the same. The dialysate supply device includes a flow controller controlling a dialysate flow, a supply pump supplying dialysate to a hemodialyzer, a recovery pump discharging dialysate from the hemodialyzer, a volume chamber storing dialysate, and a pressure-relief bypass maintaining dialysate pressure within a permissible range. The blood dialyzing apparatus includes the dialysate supply device, a blood tube, and a one-way valve disposed on the blood tube. The blood dialyzing apparatus can quickly change dialysate pressure in the hemodialyzer using the dialysate supply device having the flow controller, cylinder and piston, and increase mass transfer and hemodialysis efficiency. Also, the blood dialyzing apparatus may be miniaturized and lightened to provide a portable blood dialyzing apparatus because blood is transferred without using a blood pump.

Abstract: An automated peritoneal dialysis system and machine configured to perform dextrose mixing are disclosed. An example dialysis machine includes at least one pump, a first dialysate having a first dextrose level placed in fluid communication with the at least one pump, and a second dialysate having a second dextrose level placed in fluid communication with the at least one pump. The example dialysis machine also includes first and second valves placed between the first and second dialysates and the at least one pump. The example dialysis machine further includes a logic implementer programmed to operate the at least one pump and the first and second valves to mix the first and second dialysates so as to form a third dextrose level.

Abstract: The present invention relates to an integrated double cannula for ECMO. The integrated double cannula is configured to be inserted into a blood vessel through skin for ECMO. The integrated double cannula includes a cannula body in which a blood introduction part and a blood supply part are integrally formed inside a single pipe with a partition wall being therebetween, wherein an end of the cannula body is opened through an end hole, another end of the cannula body is opened through an outlet and an inlet arranged side by side and connected respectively to the blood introduction part and the blood supply part, and one or more side holes and one or more discharge holes connected respectively to the blood introduction part and the blood supply part are formed in a lateral portion of the cannula body.

Abstract: A device is provided for the storage, transportation and disposal of used medical syringes. The invented container provides a storage cavity for a used syringe, whereby the used syringe is preferably depressed into the storage cavity such that the top of the used syringe is substantively below a projection set, such that the used syringe may not be easily removed from the storage cavity. The invented container may further create a friction fit around the used syringe, providing an additional layer of redundancy for the prevention of the removal of the used syringe from the storage cavity. The storage cavity may be stand-alone within container, or one container may optionally contain a plurality of storage cavities. The invented container may further provide a storage area for an unused syringe, whereby the unused syringe may be removed from the container with relative facility by a user.

Abstract: An intravenous (IV) pole assembly includes a non-conductive support element, distribution rails respectively disposed along a length of the non-conductive support element and a clamping element. The distribution rails are respectively configured for power distribution along the length of the non-conductive support element. The clamping element includes a hinged clamp, which is attachable to the non-conductive support element at an attachment point defined along the length of the non-conductive support element, and a connector by which power is selectively transmittable from the distribution rails to a powered device supportable on the hinged clamp.

Abstract: An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. The processing logic includes a primary microprocessor configured to execute one or more primary applications written in a first computer language; and a safety microprocessor configured to execute one or more safety applications written in a second computer language.

Abstract: A personal injection device wearable by a user to deliver fluid from a reservoir to the user, the personal injection device including: a quartz oscillator operable to generate a constant frequency signal; a control circuit operably connected to the quartz oscillator, the control circuit being operable to generate a drive signal in response to the constant frequency signal; a stator operably connected to the control circuit and defining a rotor gap, the stator being operable to generate an oscillatory field in the rotor gap in response to the drive signal; a magnetic rotor disposed in the rotor gap, the magnetic rotor being operable to rotate in response to the oscillatory field; and a pump operably connected to the magnetic rotor, the pump being operable to move the fluid from the reservoir to the user in response to the rotation of the magnetic rotor.

Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.

Abstract: Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient's needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides adaptation of priming dose size at mealtimes for overall better glycemic control and also adapting to longer-term changes in a patient's needs. Adaptation calculations use a receding-horizon window of recent values of the adapted parameter. Doses of a counter-regulatory agent (e.g., glucagon) may also be delivered in response to information about estimated accumulation of exogenously infused insulin (subcutaneously, intramuscularly, intraperitoneally, or intravenously) and/or the effect insulin might have on glucose levels (blood glucose concentration or interstitial fluid glucose concentration).

Abstract: An injection device for injecting a medicament includes a housing, a dose setting member (20) movable to set a dose to be injected, and a signal part (7). The signal part rotates from a first rotational position to a second rotational position to increase loading on a spring or spring arm when a dose is set due to rotation of the dose setting member. An internal pressure builds up in the injection device during injection which results in the signal part being captured in the second rotational position between first and second internal parts of the injection device. After the internal pressure dissipates by a sufficient amount during injection, the signal part rotates under the urging of the loaded spring from the second rotational position back to the first rotational position. A portion of the signal part moves into contact with a surface when the signal part reaches the first rotational position to produce tactile or audible feedback indicating that an end of dose condition has been reached.

Abstract: A device for delivering a medicament into a patient's body by injection into or through the patient's skin includes a body having a reservoir disposed therein for containing the medicament, an injection needle for penetrating the skin of the patient, the needle having a lumen and communicating with the reservoir, and a pressurizing system for pressurizing the reservoir. The device also includes indicator means visible outside the device for indicating that delivery of the medicament is substantially complete.

Abstract: A system includes a syringe barrel, a syringe plunger, and an annular collar. The syringe barrel has a longitudinal axis aligned axially between a discharge end and a cylinder end. The syringe plunger has a cap disposed on a first end, a piston disposed on a second end and configured for disposition in a bore of the barrel, and has a body disposed between the first end and the second end. The body has an external thread on a first surface and the body has a visible calibration indication aligned axially. The annular collar has at least one interrupted internal thread segment on an interior surface. The collar has elasticity such that in a first state, the internal thread is configured to engage the external thread and in a second state, in which a compressive force is exerted on opposing sides of the collar, the internal thread is disengaged from the external thread.

Abstract: A medical injector has a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally toward a distal end of the body but not proximally toward a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger, thereby allowing the engagement portion to bypass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector.

Abstract: A safety catheter includes a catheter hub, a needle cannula having a tip, and a tip protector. The tip protector includes an outer member and an inner member therein. The outer member has a projection releasably engaging the catheter hub. The inner member has a pair of arms extending to free ends from a base. The inner member is axially shiftable relative to the outer member between a first position wherein the needle tip is distal of the tip protector and the free ends of the arms are spread apart such that the distal tip is not shielded, and a second position wherein the tip is within the inner and outer members and the free ends of the arms are brought into close proximity such that the distal tip is shielded. The inner member is entirely received within the outer member in both the fort and the second positions thereof.

Abstract: Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.

Abstract: A container for delivering a medicament to a target location includes a housing having a proximal end and a distal end, the housing including a cap locking tab at the distal end, and a vial containing medicament. The container includes a plunger slidable within the vial from the proximal end to the distal end of the vial to dispel the medicament, an injection member associated with the distal end, such that medicament dispelled from the vial passes through the injection member to the target location, and a slidable interaction member associated with the distal end of the vial configured to slide with the vial. An interaction between the slidable interaction member and cap locking tab causes the cap locking tabs to bias outward, and placement of a safety cap on the container after use locks the safety cap onto the container via the interaction with the cap locking tabs.

Abstract: A tip protector for a safety catheter includes an outer member releasably engaged with the interior cavity of the catheter hub. The outer member includes a generally fixed radially outwardly projecting portion to provide a holding force, and an inner member axially shiftably received within the outer member. A needle cannula received in the inner and outer members is operable to axially shift the inner member between a distal position wherein the distal tip extends distally of the tip protector, and a proximal position wherein the distal tip is within the outer member. The holding force of the outer member to the interior wall of the catheter hub remains substantially constant irrespective of the position of the inner member between the distal and proximal positions.

Abstract: A needle system for penetrating to or passing thought an object or an organ comprising a semiconductor die, one or more needles, wherein the needles move relative to the die using one or more actuators. The actuators are controlled by a controller wherein the controller instruct the needle to penetrate into or to pass through and/or retract from the object or organ. The needle system is used among other treatments for drug delivery, blood extraction, blood analysis, glucose measurements, blood measurements, nerve system stimulus treatment, hair removal, skin lesions coloring or removal or tattoo painting or removal.

Abstract: A means and a method is disclosed to diminish or eliminate the pain associated with a sharp object penetrating the skin, during such procedures as an injection, biopsy, or deriving a blood sample. To this end, repeated tapping, pressing, or rubbing or vibrating is performed over the skin at or near the site of penetration of the sharp object in conjunction with applying electricity on the skin. The invention discloses a method of using a skin-puncturing means, with enhanced features, to provide local anesthesia at the site of penetration of a sharp object.

Abstract: A novel Aromatherapy Vaporization Device is disclosed having a heating chamber first portion with an airflow restricting member and a vapor capturing chamber disposed upstream thereof. A heating chamber second portion has a low thermal inertia conductive heating element having a control circuit first electrical coupling. Phyto material is inserted between the first and second heating chamber portions for heating thereof to a predetermined temperature. A hinge is disposed between the heating chamber first portion and the heating chamber second portion for facilitating loading of phyto material into the heating chamber.

Abstract: Devices and methods are described for preparing, managing, and/or administering metered doses of substances for vaporized administration. In some embodiments, dose cartridges comprising at least one botanical substance include a heating element integrated into the cartridge in close contact with the botanical substance. In some embodiments, cartridge-mounted doses are stored in a magazine, optionally in carousel form, before use. Transport of a cartridge from a magazine to an electrically operated vaporizing chamber which activates the heating element is provided by a mechanical pickup means.

Abstract: A dry powder inhaler is provided herein which includes a dose chamber having a staging area configured to accommodate an inhalable dose of active pharmaceutical agent. A nozzle is provided having a discharge aperture with an inhalation channel communicating the staging area with the discharge aperture. The inhalation channel is configured such that sufficient negative pressure applied to the discharge aperture draws a dose from the staging area towards the discharge aperture. An arrangement is provided for evaluating the level of depletion of a dose from the staging area. Advantageously, the subject invention allows for evaluating physical depletion of a staged dose so as to recognize the level of delivery thereof.

Abstract: A device (20) is disclosed for dispensing a fluid supplied from an external fluid source. The device comprises a transducer (32) adapted to receive a fluid from the fluid source, and a collapsible linkage and trip link (502) coupling the transducer and the fluid source. The linkage has a collapsible joint inhibiting discharge of the fluid source when in a locked orientation. The device (20) further comprises a moveable member coupled to the linkage such that inhalation forces on the device cause the linkage to collapse thereby discharging the fluid from the fluid source. The device may further include a dose counter coupled to the fluid source for registering the amount of doses administered from the fluid source.

Abstract: This disclosure describes systems and methods for providing adaptive base flow scheduling during ventilation of a patient to optimize patient-machine synchrony and accuracy of estimated exhaled as well as inhaled tidal volumes. Further, this disclosure describes systems and methods for providing adaptive inspiratory trigger threshold scheduling during the adaptive base flow scheduling. Further still, this disclosure describes systems and methods for determining an estimated leak flow and adjusting the adaptive base flow scheduling and the adaptive inspiratory trigger threshold scheduling based on the estimated leak flow. Moreover, this disclosure describes systems and methods for determining a change in the estimated leak flow and adjusting the adaptive base flow scheduling and the adaptive inspiratory trigger threshold scheduling based on the change in the estimated leak flow.

Abstract: A device for delivering a substance to an airway of a patient may include a laryngeal mask airway device, at least one substance delivery reservoir coupled with the laryngeal mask airway device for delivering the substance to the airway of the patient, and at least one conduit coupled with the laryngeal mask airway. The at least one conduit may have a proximal end configured to couple with a source of the substance residing outside the patient and a distal end in fluid communication with the at least one substance delivery reservoir.

Abstract: A tracheostomy tube assembly includes an outer tube (1) and an inner cannula (20, 120, 220 51, 61) inserted into and removable from the tube. The inner cannula has a constant internal diameter along its length and has at its patient end (22, 122, 222) a seal member (23, 123, 223) extending around the cannula. The seal member may be a separate ring 23 of resilient material attached to the outside of the shaft of the cannula or it may be formed of the material of the shaft (121, 221) itself. Alternatively, the seal member (50, 60) may be of a kind that expands when exposed to an elevated temperature or humidity, and may include a shape memory effect material.

Abstract: A device for use in delivering oxygen to a human patient while measuring carbon dioxide exhaled from that patient, comprises: (a) a base member having an oxygen delivery inlet port and a carbon dioxide detection outlet port formed therein separate from the oxygen delivery port; (b) a flexible cannula extending from the base, the cannula having a proximal end portion, an intermediate portion, a distal end portion, a first lumen formed therein, and a second lumen separate from the first lumen formed therein, with the distal end portion connected to the base member, the first lumen in fluid communication with the oxygen delivery inlet port, and the second lumen in fluid communication with the carbon dioxide detection outlet port.

Abstract: A resuscitation device is disclosed comprising a bag, a non-rebreathing valve (NRV), a breathing conduit, a filter, a pressure limiting valve, a patient airway device, and an oxygen inlet located distally (on the patient side) of the bag. The device can be operatively connected to a patient airway device to provide gases to and/or exhaust gases from a patient. Also disclosed are methods of using the resuscitation device, components, and kits for constructing same. Breathing circuits for use in assisted ventilation and anesthesia are disclosed having disposable and reusable circuit components along with systems incorporating same. Methods of using the breathing circuits are described, along with descriptions of circuit components and kits for constructing systems using the breathing circuits.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermister 23), of gases flowing through a heated tube (3), supplying gases to a patient, which utilises the heating wire (21, 28) within the tube.

Abstract: Systems and methods of the present invention can enable high concentration NO to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of NO2.

Abstract: A gas analyzer for analyzing and delivering a therapeutic blend of nitric oxide gas to a patient is disclosed. The analyzer includes a nitric oxide metering circuit to meter a flow of nitric oxide into a blended gas mix, a gas sampling circuit to sample the blended gas mix, a user interface to allow a user to input a lower threshold concentration and an upper threshold concentration of nitric oxide in the blended gas mix, and a controller. In some cases, the controller is configured to operate the nitric oxide metering circuit to meter a flow of the nitric oxide into the blended gas mix to maintain the concentration of nitric oxide in the blended gas mix between the lower threshold concentration and the upper threshold concentration. Other implementations are described.

Abstract: A humidifier for humidifying a flow of air to be delivered to a patient includes a base unit having at least one wall defining a receiving space. The base unit also includes a variable volume reservoir configured to hold a body of water and receive the flow of air to humidify the flow of air for delivery to the patient. The receiving space is configured to receive the variable volume reservoir and the variable volume reservoir is conformable to a shape of the receiving space. The humidifier further includes a heater for heating the body of water.

Abstract: A respiratory assistance apparatus includes a flow generator and a humidifier. The humidifier includes a humidification chamber. The humidification chamber comprises a water tub that is configured to receive a volume of water. A lid is hingedly coupled to the water tub for enclosing a volume contained within the water tub.

Abstract: A humidifier and humidity sensor is disclosed for use with a breathing assistance apparatus. The humidity sensor preferably includes means to sense absolute humidity, relative humidity and/or temperature at both the patient end and humidifier end. The humidifier may also include provision to both control independently the humidity and temperature of the gases. Further, a chamber manifold is disclosed to facilitate easy connection of the humidifier to various outlets, inlets and sensors. A heated conduit is described which provides a more effective temperature profile along its length.