Abstract: The invention relates to an illuminated optical laryngoscope formed by an assembly, longitudinally defining a first straight segment and a second curved segment and comprising a main body (1) that is inserted into a tubular protective case (2). The curved segment of the main body (1) is formed by successive segments hinged to one another.

Abstract: The present application is directed to a colonoscope closure device. The colonoscope closure device includes an inner tubular member that defines an entry way sized to accommodate a colonoscope, an intermediate tubular member surrounding the inner tubular member, and an expandable sealing member at least partially surrounding the intermediate tubular member. The colonoscope closure device serves to prevent the escape of air during a colonoscopy procedure.

Abstract: The present invention discloses a illumination system for ophthalmic microscope and its operation method. Light beams generated by White LED, passes through the condenser and relay system to produce illumination on retina of the eye and boundary of the illumination is determined by the aperture stop. To enhance the visualization of red glow, a Single source beam then divided into two beams using divider system contains Beam splitter and mirror. Transmitted beams and reflected beams are made to focus on circular areas coated with reflective material of virtual beam splitter which is positioned coaxially with observation system of the microscope. Focused beam then passes through the objective lens of the microscopic system. Reflected beams from retina then passes through the objective lens and reaches the observation system via Virtual Beam Splitter.

Abstract: The present disclosure relates to a system for examining an eye. The system comprises a microscopy system for generating an image plane image of an object region. An OCT system of the system is configured to acquire OCT data from the object region which reproduce the object region in different stress states. A data processing unit of the system is configured to determine at least one value of a stress-dependent parameter, depending on the OCT data. The system generates an output image that is dependent on the image plane image and is furthermore dependent on the stress-dependent parameter.

Abstract: One aspect of the disclosure includes a method to assess vision function. In one embodiment, the method comprises providing a sequence of test images on a display (106) to a test subject (102) during a stimulus interval and providing a response pattern image for each of the sequence of test images during a response interval after the stimulus interval. Each of the sequence of test images includes multiple stimulus patterns (304, 306) arranged around a fixation target (302). The response pattern image includes multiple response targets (320), each of which corresponds to a location of each of the multiple stimulus patterns (304, 306). One (304) of the multiple stimulus patterns (304, 306) differs. An assessment of a vision function of the test subject (102) is based on a selection by the test subject of one of the multiple response targets (320) that the test subject indicates corresponds to a location of the multiple stimulus pattern that differs (304).

Abstract: An eyeglasses-wearing simulation method comprising: a step of creating a pair of left and right original images for enabling a patient to perform stereoscopic viewing by utilizing binocular parallax, based on virtual scene data constituted by virtual objects placed in visual field spaces of the left and right eyes; a step of calculating distortion and blur of a right eye eyeglass lens and adding the distortion and blur to the right eye original image, and calculating distortion and blur of a left eye eyeglass lens and adding the distortion and blur to the left eye original image; and a step of stereoscopically displaying the processed images viewed through the pair of left and right eyeglass lenses on a screen, wherein a value of the blur is calculated by setting a same amount of accommodation to the left and right eyes in regard to all of object points.

Abstract: A system for measuring the flow properties of a tear duct, to ascertain its flow resistance, includes a syringe communicating with a cannula to supply liquid to a punctum of an eye, the cannula having a tip to seal to the punctum. A motor is arranged to actuate the syringe. A pressure sensor monitors the pressure of the liquid supplied to the punctum. A monitoring circuit provides an indication of the flow resistance. A feedback circuit controls the motor in accordance with the measured pressure, to maintain a preset liquid pressure, or to ensure that the liquid pressure does not exceed a preset threshold. The system may prevent flow through the other punctum of the eye. If the flow rate of the liquid supplied to the punctum is also monitored, the monitoring circuit is arranged to determine the flow resistance from the pressure and the flow rate.

Abstract: A module for use with a mobile device to measure an aberration of a patient's eye includes a light shaft having a proximal end and a distal end. The light shaft includes a first plurality of optical components arranged to direct light along a first light path to the proximal end, and a second plurality of optical components arranged to direct light along a second light path to the distal end. A connector at the distal end includes at least one guide component for positioning the distal end adjacent to a light detector and a light source of the mobile device. When the distal end is positioned adjacent to the light detector and the light source, the first plurality of optical components directs light along the first light path and the second plurality of optical components directs light along the second light path.

Abstract: A method and apparatus including an interferometer is provided for sequentially recording interferometric sectional images at different depths, in particular for analyzing an eye. By use of an interferometer, which includes an optical reference path and an optical sample path, a sample beam scans a measuring region of a sample, in particular of an eye, so as to generate a deep sectional image. The optical and geometric paths in a sample arm and/or reference arm of the interferometer can be switched quickly between two or more positions. The path length of the sample beam and/or of the reference beam is changed by way of a path length switching unit, deep sectional images are generated at least at two different depths of the sample, and the change of the path length in the switching unit takes place by deflection of the beam paths to different geometric paths.

Abstract: Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and Alzheimer's disease.

Abstract: A medical diagnostic instrument or a plurality of disparate medical diagnostic instruments are configured with a common optical architecture that functionally creates a virtual eye to create closer proximity to a patient and therefore increase the field of view in regard to a target of interest. The optical system includes a distal optical element, at least one relay lens and an eyepiece lens in which the optical system can be integrated within at least one instrument or be provided using a releasable module. Additionally, at least one of a viewing assembly and illumination assembly of at least one medical diagnostic instrument can be assembled using a series of components that are connected by interlocking features.

Abstract: In one implementation, an apparatus estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point is described, estimates temperature from a digital infrared sensor and determines vital signs from a solid-state image transducer, or determines vital signs from a solid-state image transducer and estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point; after which the estimated and/or determined information is transmitted to an external database.

Abstract: In one implementation, an apparatus estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point is described, estimates temperature from a digital infrared sensor and determines vital signs from a solid-state image transducer, or determines vital signs from a solid-state image transducer and estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point; after which the estimated and/or determined information is transmitted to an external database.

Abstract: In one implementation, an apparatus estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point is described, estimates temperature from a digital infrared sensor and determines vital signs from a solid-state image transducer, or determines vital signs from a solid-state image transducer and estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point; after which the estimated and/or determined information is transmitted to an external database.

Abstract: This document discusses, among other things, systems and methods for predicting heart failure decompensation using within-patient diagnostics. A method comprises detecting an alert status of each of one or more sensors; calculating an alert score by combining the detected alerts; and calculating a composite alert score, the composite alert score being indicative of a physiological condition and comprising a combination of two or more alert scores.

Abstract: Methods for imaging a tumor in an animal including labeling an organ in the animal with a first detectable label detectable by both fluorescence molecular tomography (FMT) and magnetic resonance (MR) and localized substantially exclusively to the organ, whereupon the labeled organ is capable of use as a first fiducial marker in an image of the animal; administering to the animal a detectably labeled probe that localizes substantially exclusively to a region of interest in the body of the animal; after labeling the organ and administering the detectably labeled probe, imaging the animal with a FMT imager to generate an FMT image, and imaging the animal with a MR imager to generate an MR image; and aligning the FMT and MR images using the first fiducial marker as a first reference point, thereby generating an image comprising a fusion of the FMT image and the MR image.

Abstract: A spring type firing mechanism applied to an endoscope accessory includes a housing, a cap, a bottom cover, a driving module, a buffering module and a spring pipeline, and the spring pipeline includes a push-rod coupled to the sensor, and the driving module includes a firing spring and a restoring spring, and the two springs have different rigidities so as to form a reciprocating structure of the firing mechanism. After the sensor of the firing mechanism is triggered, the resilience of the restoring spring compresses the firing spring back to its firing length, so as to restore its position by a single driving point and allow users to complete the firing operation by one hand and simplify the operation of doctors to improve convenience and efficiency.

Abstract: A method for detecting a movable object in a location includes —providing a first 3D representation of at least part of a surface by scanning; —providing a second 3D representation of at least part of the surface by scanning; —determining for the first 3D representation a first excluded volume; —determining for the second 3D representation a second excluded volume; —if a portion of the surface in the first 3D representation is located in space in the second excluded volume, the portion of the surface in the first 3D representation is disregarded, and/or —if a portion of the surface in the second 3D representation is located in space in the first excluded volume, the portion of the surface in the second 3D representation is disregarded.

Abstract: A numerical aperture (NA) controlling unit and a variable optical probe including the same are provided. The NA controlling unit includes: an aperture adjustment unit which controls an aperture through which light is transmitted; and a focus control unit that is disposed in a predetermined position with respect to the aperture adjustment unit, that focuses light transmitted through the aperture, and that has an adjustable focal length. The variable optical probe includes: a light transmission unit; a collimator that collimates light transmitted through the light transmission unit into parallel light; an NA controlling unit that focuses light on a sample to be inspected; and a scanner that varies a path of light transmitted through the light transmission unit such that a predetermined region of the sample is scanned by light that passes through the NA controlling unit.

Abstract: Imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to removing artifacts caused by longitudinal motion of a sensor during imaging. In some embodiments, a medical sensing system includes a de-seaming engine operable to receive a first signal at a first point and second signal at a second point. The first and second points are offset from the pixel in the longitudinal direction. The de-seaming engine corrects for movement in the longitudinal direction by determining a weighted average of the first signal and the second signal. The engine determines a first probability based on the first signal and the weighted average and determines a second probability based on the second signal and the weighted average. The engine selects one of the first and second signal intensities as an intensity of the pixel based on the first and second probabilities.

Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.

Abstract: An exposure amount designation value calculation unit calculates an exposure amount designation value for designating the amount of exposure, which is required to image an observation target, based on an image signal. A threshold value calculation unit calculates a threshold value for comparison with the pixel value of the image signal according to the exposure amount designation value. A region detection unit detects a first region, in which the pixel value falls within a range set by the threshold value, and a second region, in which the pixel value is out of the range. An image generation unit generates an oxygen saturation image, in which the oxygen saturation is displayed differently in the first and second regions, using the image signal, the oxygen saturation, and information of the first and second regions.

Abstract: A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.

Abstract: After light has been output to a subject to be examined, a photoacoustic wave induced in the subject by the output light is detected. It is assumed that at least one virtual detector element is present outside of a real detector, and dummy data corresponding to the at least one virtual detector element are added to photoacoustic data in which pieces of data of the photoacoustic wave detected by the detector are arranged in accordance with the positions of detector elements. A photoacoustic image is generated by reconstructing the photoacoustic data to which the dummy data have been added by using a Fourier transform method.

Abstract: The present inventions, in one aspect, are directed to a portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, a plurality of sensors (for example, motion sensor and altitude sensor) disposed in the housing. The monitoring device may further include processing circuitry, disposed in the housing and electrically coupled to the plurality of sensor, to calculate the activity points corresponding to the physical activity of the user using the sensor data, wherein the activity points correlate to an amount and intensity of the physical activity of the user, and output the data which is representative of the activity points. The monitoring device may also include a display, coupled to the processing circuitry, may output the data which is representative of the activity points to the user.

Abstract: A method and system for determining homeostatic risk in a patient, in order to screen metabolic diseases and/or their complications and/or their treatment management, is provided. The method includes receiving, from one or more sensors coupled with the patient, galvanic skin response, bioimpedance, a photoplethysmogram (PTG), and blood pressure from the patient, calculating a first score based on the PTG, calculating a second score based on the galvanic skin response, calculating a third score based on the bioimpedance, calculating a fourth score based on the blood pressure, calculating a homeostatic risk score based on the first, second, third and fourth scores that were calculated, wherein the homeostatic risk score corresponds to the homeostatic risk of the patient, and displaying the homeostatic risk score.

Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.

Abstract: An apparatus, a system, and a method for monitoring and/or performing a diagnosis. A first implantable device measures a property of a first tissue in a body and includes a housing. The housing includes a first processing circuitry for causing the first implantable device to measure the property of the first tissue. A second implantable device for measures a property of a second tissue in the body and includes a housing. The housing includes a second processing circuitry for causing the second implantable device to measure the property of the second tissue using at least one sensor. The second implantable device is communicatively coupled to the first implantable device and provides information about the measured property of the second tissue to at least one of the following: the first implantable device and at least one processing device disposed externally to the body.

Abstract: A mobile plethysmographic device for detecting a premature ventricular contraction event is disclosed herein. The mobile plethysmographic device generates a pleth waveform, which is automatically screened by algorithms that measure the waveform to correlate, detect and store aberrations related to heart anomalies. A premature ventricular contraction event for a patient is determined based on an identification of a time interval of the pleth waveform that is below the threshold minimum time interval followed immediately by a time interval that is above the threshold maximum tine interval.

Abstract: A method and system for non-invasive assessment of renal artery stenosis is disclosed. A patient-specific anatomical model of at least a portion of the renal arteries and aorta is generated from medical image data of a patient. Patient-specific boundary conditions of a computational model of blood flow in the portion of the renal arteries and aorta are estimated based on the patient-specific anatomical model. Blood flow and pressure are simulated in the portion of the renal arteries and aorta using the computational model based on the patient-specific boundary conditions. At least one hemodynamic quantity characterizing functional severity of a renal stenosis region is calculated based on the simulated blood flow and pressure in the portion of the renal arteries and aorta.

Abstract: Technology for processing an electrocardiograph (ECG) signal is disclosed. The ECG signal can be identified, wherein the ECG signal is affected by baseline wander noise. Signal processing can be performed on the ECG signal affected by baseline wander noise in order to determine a start time and an end time for individual waveforms in the ECG signal affected by baseline wander noise. Features for the individual waveforms in the ECG signal can be extracted, wherein the features indicate one or more cardiac function metrics.

Abstract: Self-correlation enhancements and implementations are described. In particular, certain examples demonstrate the use of a peak selector to identify peaks of a self-correlation function which serve as candidate cardiac rates for an implantable medical device. The approach may enable an alternative calculation of cardiac rate in an implantable medical device as a stand-alone rate detector or as a double-check of other rate calculations.

Abstract: The present specification discloses systems and methods of patient monitoring in which multiple sensors are used to detect physiological parameters and the data from those sensors are correlated to determine if an alarm should, or should not, be issued, thereby resulting in more precise alarms and fewer false alarms. Electrocardiogram readings can be combined with invasive blood pressure, non-invasive blood pressure, and/or pulse oximetry measurements to provide a more accurate picture of pulse activity and patient respiration. In addition, the monitoring system can also use an accelerometer or heart valve auscultation to further improve accuracy.

Abstract: Software and apparatus are provided to automatically detect and map areas of complex fractionated electrograms within cardiac chambers. Electrogram signal are analyzed to count the number of complexes whose amplitude and peak-to-peak intervals meet certain criteria. Functional maps indicating average complex interval, shortest complex interval, and confidence levels are produced for display.

Abstract: A method and system provides for electrophysiological data analysis in a networked processing environment. The method and system includes receiving, via a networked connection, electrophysiological data of a patient and electronically performing, via at least one network processing device, a data analysis on the electrophysiological data. The method and system includes generating at least one report based on the data analysis, wherein the at least one report includes determination of one or more intervention options for the patient and therein transmitting the report to a recipient device across the network connection for utilization with the patient. The results of the report direct the user to apply from within the same system non-invasive brain stimulation, neurofeedback, and biofeedback modalities.

Abstract: A medical imaging apparatus includes a positioning image acquisition unit which acquires a positioning image concerning a subject, a unit which sets an region of interest in the positioning image in accordance with specification performed by an operator, a monitoring image acquisition unit which repeatedly acquires a monitoring image concerning the subject at predetermined time intervals, and a generation unit which combines an region-of-interest image representing the region of interest with the monitoring image to generate a display image every time the monitoring image is acquired.

Abstract: A subject-specific skeletal model of a body is created, and an intended path of a catheter within the body is defined in the model. While the probe is inserted into the body electrical currents are passed through the body between at least one electrode in the probe and through respective electroconductive location pads that are disposed at a plurality of locations on the body surface along the intended path. Based on respective characteristics of the currents passing through the plurality of locations, position coordinates of the probe are iteratively determined. The actual path of the probe is tracked with reference to in the model using the iteratively determined position coordinates to determine whether the actual path corresponds to the intended path.

Abstract: Apparatus and methods are described for use with an endoluminal data-acquisition device configured to be moved through a lumen, the device having a radiopaque marker coupled thereto. While the device is being moved through the lumen (a) endoluminal data points of the lumen are acquired using the device, (b) contrast agent is continuously injected into the lumen, and (c) angiographic images of the device are acquired. It is determined that endoluminal data points correspond to respective locations within the lumen, by determining locations of the radiopaque marker within the angiographic images of the lumen, by performing image processing on the angiographic images, the locations of the radiopaque marker within the angiographic images of the lumen corresponding to respective endoluminal data points. Other applications are also described.

Abstract: Systems and/or methods for diagnosing sleep disorders in a patient are provided. In certain example embodiments, articles of bed clothing and/or bed sheets comprising sensors operable to obtain patient condition data related to sleep-disordered breathing (SDB) are provided to patients. The patient condition data is stored to a data recorder operably connected to the sensors. The sensors and the data recorder may communicate wirelessly. The bed clothing (e.g. wearable articles of clothing, bed sheets or mats, pillows, etc.) may have batteries and/or battery fibers disposed therein to power the sensors. In certain example embodiments, a bed sheet may be physically connected to a power supply and/or the data recorder. In certain example embodiments, a bed sheet and articles of bed clothing both may be provided to the patient.

Abstract: An interactive virtual care system may include a user sensory module to acquire multi-modal user data related to user movement. A data analysis module may compare the multi-modal user data to predetermined historical user data and/or statistical norm data for users to identify an anomaly in the user movement.

Abstract: A base station identifies user-wearable devices being worn by a user, wherein each of the user-wearable devices is battery powered, includes a plurality of sensors, performs wirelessly communication, and is worn on a separate portion of the user's body. For each of the user-wearable devices, the base station identifies a portion of the user's body on which the user-wearable device is being worn. The base station also identifies an activity in which the user is engaged, and identifies multiple types of sensor data to be sensed using the sensors of the user-wearable devices, to enable tracking of metric(s) relevant to the activity in which the user is engaged. The base station determines how to distribute sensing responsibilities for the multiple types of sensor data among the sensors of the user-wearable devices being worn by the user, and selectively activates and deactivates individual sensors of each of the user-wearable devices.

Abstract: A filter device for a hearing test probe and a method of manufacturing a filter device are disclosed. The filter device extends along a center axis in a first direction from a first end to a second end. The filter device comprising: a first part having a first filter structure, a second part having a second filter structure, a first channel extending along the center axis. The first part and second part are joined together, and the first filter structure and the second filter structure define a filter element with a first set of filter openings for the first channel.

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level with a sample present in target area based on the calculated attenuance with the processor.

Abstract: The present invention relates to a biological information measurement device and a biological information measurement method using the same, and is intended to allow appropriate measurement to be carried out. In the biological information measurement device of the present invention, a control unit 18 is allowed to execute a pre-processing voltage application mode A and a biological information measurement mode C. Furthermore, in the biological information measurement device of the present invention, the hematocrit value of blood is calculated in either the pre-processing voltage application mode A or the biological information measurement mode C, and according to the hematocrit value thus calculated, the duration for applying a measuring voltage upon and after the calculation of the hematocrit value is modified.

Abstract: Methods and apparatuses for determining an analyte value are disclosed.

Abstract: A lancing device (1) for taking blood samples comprises a housing (2), an axially displaceable lancet holder element (32) for holding a replaceable lancet (12), and a drive unit (30) comprising at least a lancing spring element (31) for driving the axially displaceable lancet holder element (32) in a lancing direction (18). The lancing device further comprises a tensioning carriage part (26) which can be fixed in a tensioning position (36) for tensioning the lancing spring element (31). The fixable tensioning carriage part (26) is temporarily axially fixed in this tensioning position (36) by means of a latching apparatus (35) which can be latched to the axially displaceable lancet holder element (32).

Abstract: A system for providing feedback during ligament insertion in knee joint orthopedic surgeries includes an imaging device providing knee joint articular surface geometry data, a position measuring device providing distal ligament insertion sites, a strain measuring device providing ligament reference strain, a drive system providing a prescribed kinematic path for the knee joint and an adaptive migration application. The adaptive migration application receives inputs including the knee joint articular surface geometry data, the distal ligament insertion sites, the ligament reference strain and the prescribed kinematic path for the knee joint and generates outputs including sets of isotonic, hypertonic and hypotonic points representing proximal insertion sites of ligament fiber associated with prescribed distal ligament insertion sites.

Abstract: An approach for monitoring a sleeping subject includes receiving an input for specifying an attachment position of a monitoring device attached to a subject, calibrating a resting positioning of the subject based on the attachment position, analyzing sensor information collected from the monitoring device to determine a movement of the subject into a potentially dangerous position with respect to the calibrated resting position, wherein the monitoring device includes an array of sensors including an accelerometer, one or more biometric sensors, or a combination thereof.

Abstract: An apnea episode determination device includes, a processor; and a memory which stores a plurality of instructions, which when executed by the processor, cause the processor to execute, detecting a breathing segment and a midway segment from a sound signal during sleep, the breathing segment being considered to include a breathing sound, the midway segment existing in between the breathing segments; calculating an acoustic feature based on a background noise component and a signal component excluding the background noise component, which are included in the midway segment; and determining that the midway segment is an apnea episode when the acoustic feature meets a preset condition.

Abstract: A device for monitoring a medical prosthesis and the human body includes a sensor for generating signals depending on surrounding stresses, a processor for processing the signals emitted by the sensor in order to convert the signals into data, a storage device for storing the data, a device for wireless transmission of the stored data, and a supply of electrical energy. The device is included in at least one casing, which is made of biocompatible material and has a device for fixing to a bone.