Abstract: The present invention aims to provide a bone regeneration material kit, a paste-like bone regeneration material, a bone regeneration material, and a bone bonding material, which contain particles including a bioabsorbable polymer; and can fill a bone defect or damage and secure the mechanical strength of the bone in the short term and can promote regeneration of the patient's own bone in the long term. In addition, they can exhibit anti-washout properties after filling even when they are in contact with water such as blood or biological fluids. The present invention relates to a bone regeneration material kit comprising: a particle comprising a calcium salt and having an inositol phosphate or salt thereof adsorbed on the surface; a particle comprising a bioabsorbable polymer; and an aqueous medium.

Abstract: There is disclosed a synthetic, composite graft to support robust bone growth. In an embodiment, the synthetic, composite graft includes a synthetic scaffold material including a material resorbable through natural cellular processes; a signaling factor combined with the scaffold material; a cell adherence factor coated on the scaffold material; a quantity of viable bone forming cells adhered to the scaffold; and a matrix substrate binding the scaffold material. There is disclosed a method of forming a synthetic, composite graft to support bone growth for bone grafting. In one embodiment, the method includes providing a synthetic scaffold material including a material resorbable through natural cellular processes; combining a signaling factor with the scaffold material; coating a cell adherence factor on the scaffold material; adhering a quantity of viable bone forming cells to the scaffold; and encasing the scaffold material with a matrix substrate. Other embodiments are also disclosed.

Abstract: An osteoimplant includes at least partially demineralized cancellous bone as a substrate, which is impregnated with demineralized cortical bone matrix (DBM). The implant may include a binding agent to adhere the DBM to the cancellous bone substrate, and may also include a soft tissue barrier that covers a portion of the external surface of the implant. The cancellous bone substrate may be selectively demineralized, so as to provide regions with greater malleability, and other regions with greater structural properties.

Abstract: The present invention provides a preparation method for implantable medical biological material of animal origin comprising the following procedures: Pre-processing, and washing of animal tissue materials; inactivation of virus; decellularizing cell; sodium chloride processing; molding and packaging sterilization. Cell-free ECM materials of animal origin produced by this method can achieve the goal of completely removing cell components of animal origin and composition of DNA, and at the same time, the natural ECM composition, three-dimensional structure and active growth factor which can induce and promote tissue regeneration retain. By using this process, endotoxin, organic solvents and toxic solvent residue are thus omitted and products with different sizes, thickness and mechanical strength can be formed.

Abstract: In order to provide (i) a medical composition that has a strong angiogenic effect, has low invasiveness to a body of a patient, and is easy to administer to a living subject and (ii) a medical kit using a medical composition, the medical composition includes: a carrier in a particle form, the carrier having (a) a support made from a bioabsorbable polymer and (b) a surface layer made from hydroxyapatite and provided on the support; and cells provided on a surface of the carrier.

Abstract: The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane.

Abstract: Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.

Abstract: The implantable scaffold matrix composition for osteogenic regeneration has a biodegradable polymer material selected from the group consisting of one or more of polylactic acid, polyglycolic acid, or polycaprolactone, or any combination thereof to provide a time release delivery of an osteogenic effect and further has a pharmaceutical composition selected from the group consisting of one or more of ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDS), acetaminophen, or naproxen sodium or any combination thereof and wherein the implantable composition has a primary and a secondary time release. The primary time release being one of the polymer compositions; each time release extending occurring between 0 days and 19 days, both not being at 0 days.

Abstract: A tissue scaffold includes a first film having a plurality of cell openings and a second film adjacent the first film and having a plurality of cell openings larger than the cell openings of the first film. The cell openings of the first film interconnect with the cell openings of the second film to define pathways extending through the first and second films.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.

Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.

Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.

Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate.

Abstract: Apparatus and a method for the provision of topical negative pressure therapy to a wound site are described, the apparatus comprising: vacuum generating means for generating a negative pressure at said wound site said vacuum generating means being operably connected to a dressing at said wound site by aspiration conduit means; pressure sensing conduit means in fluid communication with said aspiration conduit means at a junction adjacent said dressing; first pressure sensing means between said junction and said vacuum generating means; second pressure sensing means operably associated with said pressure sensing conduit means; diagnostic means in communication with said first and second pressure sensing means; and control means in communication with said diagnostic means for controlling pressure in said aspiration and said pressure sensing conduit means.

Abstract: Apparatus (10, 200) for the provision of TNP therapy to a wound is described, the apparatus (10, 200) including: a waste canister (22, 204) into which fluid is aspirated from a wound by aspiration pump means (44, 248) and a fluid flow path (420, 422) for at least a part of said aspirated fluid on an outlet side of said aspiration pump means (44) wherein said fluid flow path (420, 422) on the outlet side comprises a silencing system (400) having a plurality of silencing elements (402, 404, 406) therein.

Abstract: A colostrum collection system includes a breast cup, an intermediate reservoir, a syringe attached below the intermediate reservoir, and a vacuum pump drawing vacuum from the breast cup and syringe, through the intermediate reservoir. The vacuum pump maintains vacuum throughout a vacuum pump cycle, but varies the level of the vacuum between a low vacuum and a high vacuum. During high vacuum, the colostrum is drawn from the breast and into the intermediate reservoir, and air is drawn from the syringe creating reduced air pressure in the syringe. During low vacuum, the colostrum is drawn into the syringe by the reduced air pressure in the syringe.

Abstract: Dressings, systems, and methods are disclosed for treating tissue with reduced pressure. A dressing for distributing reduced pressure to a tissue site includes a plurality of liquid-impermeable layers that are stacked and a plurality of spacers disposed at least partially between adjacent liquid-impermeable layers. The plurality of liquid-impermeable layers are fenestrated at least in part. The plurality of spacers and plurality of liquid-impermeable layers form a plurality of flow paths for allowing fluid flow under reduced pressure. Adjacent layers of the plurality of liquid-impermeable layers are stacked without foam between at least a majority of coextensive surfaces. Other dressings, systems, and methods are disclosed.

Abstract: A reduced-pressure treatment system for treating a tissue site on a patient includes a gasket releasably attached around a perimeter of the tissue site that may remain in place for an extended time and allows an over-drape to be attached to it. The system and method further may include a manifold sized and configured to be placed in contact with the tissue site; the over-drape positioned over the manifold and sealed to the gasket to create a sealed space between the over-drape and the tissue site; and a reduced-pressure source fluidly coupled to the sealed space to deliver reduced pressure to the tissue site. A method is also presented.

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound, includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, a portable subatmospheric pressure mechanism dimensioned to be carried or worn by the subject and a container for collecting exudates from the wound bed removed under the subatmospheric pressure supplied by the subatmospheric pressure mechanism. The portable subatmospheric pressure mechanism includes a housing, a subatmospheric pressure source disposed within the housing and in fluid communication with the wound dressing to supply subatmospheric pressure to the wound dressing and a power source mounted to or within the housing for supplying power to actuate the subatmospheric pressure source.

Abstract: A buoy or float can be positioned within a separation container to assist in a physical separation of components of a whole material positioned in the separation container. The buoy can be positioned within the container to move from between and separation a first end and a second end of the container substantially unaffected by a portion of the whole material, including a clotted portion thereof. A first port can be provided near the first end of the container for introduction of the whole material and a second port can be provided near the second end of the container for removal of at least a portion of a separated material.

Abstract: The present invention provides methods and direct cardiac contact device to improve the diastole phase and the systolic phase of a heart and includes a biocompatible film pneumatic locked to the heart to aid in heart compression and relaxation.

Abstract: An external transmitter inductive coil can be provided in, on, or with a belt designed to be placed externally around a part of a body of a patient. An implantable device (such as a VAD or other medical device) that is implanted within the patient's body has associated with a receiver inductive coil that gets implanted within that part of the patient's body along with the device. The externally-located transmitter inductive coil inductively transfers electromagnetic power into that part of the body and thus to the receiver inductive coil. The implanted receiver inductive coil thus wirelessly receives the inductively-transferred electromagnetic power, and operates the implant.

Abstract: The present invention provides a zero-emission dialysis clinic including a building envelope, daylight concept, lighting concept, mechanical ventilation (71), a chilled and heated ceiling (61) with capillary tubes (60), heat pump (50), and a photovoltaic system (80). Specifically, the present invention balances the energy consumption with energy generation by a photovoltaic system. The CO2 emissions are thus balanced and the building produces no net emissions.

Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. The system includes a blood fluid removal device configured to set the initial fluid removal volume and rate prescription. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.

Abstract: A renal failure therapy machine includes a blood cleaning filter, a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter, a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance.

Abstract: A dialysis catheter includes an elongate catheter member having an outer wall member defining proximal and distal end regions, and first and second longitudinal lumens. The outer member includes first and second ports in respective fluid communication with the first and second longitudinal lumens. The first opening and the first lumen define an inflow passage. The second opening and the second longitudinal lumen define an outflow passage. A valve is disposed relative to the outer member proximal of the first port. The valve is adapted to move from a closed position to an open position in response to a predetermined vacuum pressure level realized within the first longitudinal lumen to permit flow of blood through the valve and into the first longitudinal lumen. The valve may be adapted to move to the open position in the event of a luminal occlusion.

Abstract: A needle magazine (1, 100) attachable to an injection device containing a liquid drug and which magazine (1, 100) comprises a main part (10, 110) and revolving part (20, 120) which can be rotated to bring a selected needle cannula (35, 135) into an injection position. The magazine (1, 100) is provided with a centrally located tube (13, 113) for penetrating into the injection device and has an internal conduit (14, 114, 115) for guiding the liquid drug from the tube (13, 113) and to a peripheral area of the magazine (1, 100). In this peripheral area a plurality of needle cannulae (35, 135) are provided which needle cannulae (35, 135) successively can be brought into liquid communication with the liquid drug in the conduit (14, 114, 115) by axial movement of the revolving part (20, 120).

Abstract: An apparatus (130) and a method for adjusting, in perfusion imaging system, a periodic contrast agent injection rate signal (IS) for an injector (135) as function of an image sampling rate determined by the rotational speed of an X-ray source (107)-detector (109) assembly of an X-ray imager (100). Frequency, periodicity and pulse width of the contrast agent injection rate signal (IS) is adjusted to mitigate temporal signal aliasing in a sample of a time attenuation contrast (TAC) signal.

Abstract: A cassette apparatus for an infusion pump includes a cassette for operatively connecting administration set tubing to the infusion pump and a cassette interface a cassette interface on the infusion pump for removably receiving the cassette. The cassette includes a press tab having an upwardly facing press surface and an undersurface, and the cassette interface includes at least one fulcrum member, wherein the undersurface of the press tab engages the fulcrum member(s) when the cassette is received by the cassette interface. As a result, the cassette is pivotable relative to fulcrum member(s) by pressing the press surface of the press tab to assist in removing the cassette from the cassette interface.

Abstract: In a method of determining a flow rate in an intravenous fluid delivery system according to one embodiment of the present invention, the fluid delivery channel forms a segment of the intravenous infusion system. An input thermal signal is emitted into a source location of a fluid delivery channel at an emitting instant. A first output thermal signal is received from a first sensor location of the fluid delivery channel at a first receiving instant. The first sensor location is positioned with a first interval downstream from the source location. The input thermal signal, the first output thermal signal, the emitting instant, the first receiving instant and the first interval define a first measured thermal profile. The first measured thermal profile is matched with a reference thermal profile which corresponds to a reference value, and the flow rate can be determined.

Abstract: Catheter monitor integration with patient support systems, such as patient beds, and with other healthcare communication systems including hand hygiene systems is provided. A patient bed that transmits bed data and catheter monitor data is disclosed. When catheter tubing is connected to a catheter monitor integrated into a patient bed, the bed automatically implements a falls prevention protocol. A countdown timer pertaining to removal of catheter tubing from a patient is displayed on one or more display devices. Monitoring for caregiver handwashing compliance in connection with use of a catheter monitor or a catheter kit is also provided.

Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.

Abstract: A stopper includes a main body portion defining an open rearward end configured to receive the plunger rod, an engagement portion provided along an inner circumference of the main body portion configured to engage at least a top portion of the plunger rod, a closed front end forming a flexible roof, and a first perimetrical skirt extending around an outer circumference of the main body portion toward the closed front end of the main body portion. When fluid pressure is increased inside the syringe barrel during an injection, the flexible roof expands in a radial direction toward an inner wall of the syringe barrel, the first perimetrical skirt is forced against the inner wall of the syringe barrel, and an engagement between the plunger rod and the engagement portion forces the main body portion to expand in the radial direction toward the inner wall of the syringe barrel.

Abstract: A medical device having a barrel, a retractable needle, a needle retraction assembly and a plunger, the needle retraction assembly including and being held inside the barrel prior to retraction at least in part by a retainer member contacting the barrel, the plunger comprising a plunger seal with an body having at least a portion that is rearwardly moveable relative to the plunger and an elastomeric web that seals a retraction cavity inside the plunger prior to retraction of the needle, the retainer member and the plunger seal each cooperating with an inside wall of the barrel to provide a sealed liquid containment chamber inside the device.

Abstract: A safety needle assembly is provided herein which includes a hub; a needle fixed to the hub; a first shield having a tubular body at least partially encircling a portion of the needle, wherein in an initial state, the first shield extends from the hub; a second shield having a tubular body at least partially encircling a portion of the needle; a biasing element disposed to urge the second shield distally towards a distal end of the needle; and, a releasable retaining arrangement for releasably retaining the second shield in a first state. Upon a predetermined extent of proximal movement of the first shield relative to the hub, the second shield is released to a second state in which the distal end of the needle is covered. Advantageously, two shields are provided for at least partially covering a needle with one of the shields acting as a trigger.

Abstract: A needle protecting module of an injection device in connecting with a syringe has a needle base, a needle body a tube module, a mounting tube, an elastic unit, and a stopping unit. The syringe has a tube body and an axis. The needle body transfixes the needle base and communicates with the tube body for medication injection. The needle base is removably engaged with the tube body and bearing the needle protecting module is transfixed by the needle body. The tube module is mounted around the needle base and has an annular space. The mounting tube is movably inserted into the annular space. The elastic unit is mounted in the annular space and abuts both the mounting tube and the needle base bilaterally. The stopping unit is moveably mounted in the annular space and is selectively engaged with the mounting tube.

Abstract: The present invention relates to a safety pen needle device comprising a first needle shield (60) and a second back-end needle shield (90). During the injection the first needle shield (60) is moved to en retracted position this movement causes a actuation sleeve (31) to rotate. Said rotation causes a holding member (96, 98) provided on the second needle shield (90) to be released. When the first needle shield (60) is moved from the retracted position to a extended position the actuation sleeve (31) is rotated further so that a first guide member (74) on the first needle shield (60) abuts a first stop member (34) arranged on said actuation sleeve (31). After an performed injection both shields are moved to extended positions by the rotation of an actuation sleeve (31). After the injection the shield are locked it their extended position.

Abstract: A system and method for warming a fluid for intravenous administration is presented. The system includes an enclosure, a frangible bladder disposed at least partially within the enclosure, and a first reactant of an exothermic reaction disposed within the frangible bladder. The apparatus includes a second reactant of the exothermic reaction disposed within the enclosure and external to the frangible bladder, and a channel at least partially enclosed by the enclosure. The frangible bladder is configured to be ruptured to mix at least a portion of the first reactant and the second reactant to initiate the exothermic reaction, thereby warming at least a portion of the channel.

Abstract: An indirectly heated capillary aerosol generator comprises a capillary tube adapted to form an aerosol when liquid material in the capillary tube is heated to volatilize at least some of the liquid material therein and a thermally conductive material in thermal contact with the capillary tube. The indirectly heated capillary aerosol generator provides substantially even and uniform heating across the heated length of the capillary tube.

Abstract: System and methods for providing respiratory therapy include predetermined and/or automatically determined perturbations of levels of pressure, flow, and/or other gas parameters integrated and/or combined (Start with a supplied pressurized flow of breathable gas for a subject. The perturbations are intended to improve secretion management through intra-pulmonary percussive ventilation integrated with ventilation therapy.

Abstract: The present invention provides a method for producing a filled hollow structure, preferably a cushion for a breathing mask. According to said method, a hollow structure of a first material having a cavity is produced, wherein the hollow structure has an inlet to and an outlet from the cavity. The hollow structure is positioned on a tool for holding the hollow structure. Subsequently a second material is inserted through the inlet into the cavity, while gas present in the cavity can escape through the outlet. Finally, the inlet and/or the outlet is sealed. During the step of inserting the second material through the inlet into the cavity the outlet resists flow of said second material.

Abstract: Mask system includes frame, cushion, cushion clip, swivel elbow, headgear and/or headgear clips configured for use in a clinical or hospital environment. One or more components of the mask system configured to promote single patient use, for example, by providing an age indicator and/or preventing disassembly and/or cleaning.

Abstract: A heater wire for removing condensation from a respiratory gas conduit is provided. The heater wire includes at least one groove disposed thereon. The heater wire is positioned in a respiratory gas conduit. The groove may wick up water from a condensation region within the respiratory gas conduit and transport the wicked up water from the condensation region to a re-evaporation region. The wicked up water may be evaporated by a hot surface of the wire.

Abstract: An adapter includes a housing having an inlet port defining a flow path and an outlet port. An interior wall has an inner surface defining an interior passageway communicating with the outlet port and an exterior surface defining an exterior passageway communicating with the inlet port. The interior wall defines a mouth communicating between the interior and the exterior passageways. The interior wall is positioned transverse to the flow path of the inlet port. A medicament delivery port opens into the mouth. A valve is moveable between a closed position, wherein the valve closes the medicament delivery port, and an open position, wherein the medicament delivery port is open. A ventilator circuit and method of delivering a medicament are also provided.

Abstract: An apparatus for preparing a mixture suitable for a hyperthermal inhalational treatment of an upper portion of respiratory tract is disclosed. The apparatus includes a vertical wall defining an interior compartment, wherein a mixture of mist and vapors of an inhalant is formed. A preferably added module for a hyperthermal inhalational treatment combined with administration of pharmaceuticals and/or saline is disclosed as well.

Abstract: A modular catheter assembly includes a holder, having a proximal end and a distal end. An electrode sheath carrier is mounted on the distal end of the holder. A shape-imparting element carrier is removably mountable to an end of the holder and is accessible externally of the holder with at least the shape-imparting element carrier being replaceably mounted to the holder.

Abstract: A multi-section tubular member including a sleeve surrounding and bridging a joint between a first section and a second section of the tubular member, and a method of forming a multi-section tubular member are disclosed. A polymeric sleeve may extend over a portion of the first section and an adjoining portion of the second section. A length of heat shrink tubing may be placed over the sleeve and heated, thereby compressing the heat shrink tubing around the sleeve. The sleeve may then be thermally bonded to each of the first section and the second section. The heat shrink tubing may then be removed, leaving the sleeve securely joining the first section and the second section to form a multi-section tubular member.