Patents Issued in May 18, 2017
  • Publication number: 20170137876
    Abstract: The present invention provides methods of increasing sequencing accuracy. For example, the methods of the invention use linear amplification to generate a relatively small population of template molecules that may be subsequently amplified into a larger clonal population of DNA molecules for sequencing.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 18, 2017
    Inventors: Roberto RIGATTI, Jonathan Mark BOUTELL
  • Publication number: 20170137877
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Application
    Filed: September 21, 2016
    Publication date: May 18, 2017
    Inventors: Nathaniel Joseph MCCAFFREY, Stephen TURNER, Ravi SAXENA, SR., Scott Edward HELGESEN
  • Publication number: 20170137878
    Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 18, 2017
    Inventors: Mong Sano Marma, Jerzy Olejnik, IIia Korboukh
  • Publication number: 20170137879
    Abstract: Methods and formulations for diagnosing metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 18, 2017
    Inventors: Niven Rajin NARAIN, John Patrick McCOOK, Rangaprasad SARANGARAJAN
  • Publication number: 20170137880
    Abstract: The present invention provides methods for treating depression such as major depressive disorder (MDD) in an individual. The invention further provides methods for determining if an individual suffering from depression is likely to respond favorably or experience an enhanced treatment effect in response to treatment with vortioxetine. The present invention also provides methods for treating cognitive impairment in an individual, optionally wherein the individual also suffers from depression and/or MDD. The invention further provides methods for determining if an individual suffering from cognitive impairment is likely to respond favorably or experience an enhanced treatment effect in response to treatment with vortioxetine.
    Type: Application
    Filed: March 4, 2015
    Publication date: May 18, 2017
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Jarlath Ffrench-Mullen, Eric Lai
  • Publication number: 20170137881
    Abstract: Disclosed is an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from the subject or the determination of the nucleotide at the polymorphic position 16519 in the mitochondrial DNA of the subject. Also, disclosed are nucleic acids suitable for the in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject.
    Type: Application
    Filed: March 27, 2015
    Publication date: May 18, 2017
    Inventors: Marta BARRACHINA CASTILLO, Isidre FERRER ABIZANDA, Marta BLANCH LOZANO
  • Publication number: 20170137882
    Abstract: The present invention relates to the technical field of organ and tissue transplantation and specifically to methods allowing rejection of transplanted organs and tissues by a transplant patient. The present invention provides methods for non-invasive and ex vivo or in vitro detection of the presence or absence of transplant rejection, i.e. transplant health or rejection. The present methods allow for effective and continuous monitoring of transplant status with a minimal or absent discomfort for a transplant patient.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Inventors: Dirk GOOSSENS, Joachim DE SCHRIJVER, Jurgen DEL FAVERO
  • Publication number: 20170137883
    Abstract: Disclosed herein are methods for diagnosing acute cellular rejection (ACR) of an allograft by analysis of predictive gene sets and kits for practicing these methods.
    Type: Application
    Filed: June 26, 2015
    Publication date: May 18, 2017
    Inventors: Barbara Murphy, Weijia Zhang
  • Publication number: 20170137884
    Abstract: Truncation variants of BCR-ABL mRNA that produces BCR-ABL proteins with a truncated C-terminus and its role in resistance to treatment with kinase inhibitors is described. Vectors for expressing the truncated gene products are described as well as recombinant cells that express the truncated gene products from cDNA constructs. Also provided are methods compositions and kits for detecting the BCR-ABL truncation variants. Also provided are methods for determining the prognosis of a patient diagnosed as having myeloproliferative disease, and methods for predicting the likelihood for resistance to a treatment with tyrosine kinase inhibitor in a patient diagnosed as having myeloproliferative disease. Additionally, methods for screening BCR-ABL tyrosine kinase domain inhibitors which rely on the recombinant cells are also disclosed.
    Type: Application
    Filed: November 3, 2016
    Publication date: May 18, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Maher Albitar, Wanlong Ma
  • Publication number: 20170137885
    Abstract: By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Daniel R. Salomon, John Friedewald, Sunil Kurian, Michael M. Abecassis, Steven Head, Phillip Ordoukhanian
  • Publication number: 20170137886
    Abstract: Disclosed herein are compositions and methods relevant to a novel Drug Metabolism Reserve Physiotype to determine the metabolic capacity of a human individual. The Drug Metabolism Reserve Physiotype allows the determination of the innate metabolic capacity of the patient relevant to antidepressant and stimulant treatment and can be predicted and diagnosed simply from a blood sample. In the disclosed method, an individual is genotyped for a plurality of polymorphisms in a gene encoding CYP2C9, a gene encoding CYP2C19 and a gene encoding CYP2D6, and the genotypes are used to produce four novel indices, which relate to the metabolic capacity of the human individual.
    Type: Application
    Filed: January 26, 2017
    Publication date: May 18, 2017
    Inventors: GUALBERTO RUANO, DAVID VICTOR VILLAGRA, MOHAN RANJIT KUMAR KOCHERLA, ANDREAS WINDEMUTH, JOHN W. GOETHE
  • Publication number: 20170137887
    Abstract: The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.
    Type: Application
    Filed: January 31, 2017
    Publication date: May 18, 2017
    Applicants: The Hospital for Sick Children, Centre for Addiction and Mental Health
    Inventors: Berge A. Minassian, John B. Vincent
  • Publication number: 20170137888
    Abstract: Method and compositions for screening for the presence of Epidermal Growth Factor Receptor variant 3 (EGFR(v3)) in a sample are described. The method comprises obtaining a sample containing a plurality of cells; hybridizing a set of chromosomal probes to the sample, wherein the set comprises an EGFR(v3)-probe and a probe to chromosome 7 different from an EGFR(v3)-probe; and visualizing the hybridization pattern of the set of chromosomal probes in the plurality of cells of the sample, wherein the presence of at least one copy of chromosome 7 lacking a hybridization signal of the EGFR(v3)-probe in at least one cell is indicative of the presence of the EGFR(v3) in the sample. The method and compositions are suitable for diagnosing the therapeutic outcome for treating a patient having a cancer with an anti-EGFR therapeutic agent and for screening a sample for a predisposition for forming an EGFR-associated cancer.
    Type: Application
    Filed: July 27, 2016
    Publication date: May 18, 2017
    Inventors: Susan S. Jewell, John C. Russell, Larry E. Morrison
  • Publication number: 20170137889
    Abstract: The invention provides to RAF1 gene fusions, RAF1 fusion proteins, and fragments of those genes and polypeptides. The invention further provides methods of diagnosing and treating diseases or disorders associated with RAF1 fusions, such as conditions mediated by aberrant RAF1 expression or activity, or overexpression of RAF1.
    Type: Application
    Filed: June 10, 2015
    Publication date: May 18, 2017
    Applicant: BLUEPRINT MEDICINES CORPORATION
    Inventors: Nicolas Stransky, Joseph L. Kim
  • Publication number: 20170137890
    Abstract: The disclosure provides for molecular classification of disease and, particularly, molecular markers for breast cancer prognosis and methods and systems of use thereof.
    Type: Application
    Filed: October 21, 2016
    Publication date: May 18, 2017
    Inventors: Jerry Lanchbury, Alexander Gutin, Darl Flake
  • Publication number: 20170137891
    Abstract: Methods of determining risk of recurrence of a breast cancer of a subject are provided. Also provided are methods of predicting responsiveness to a therapy of a breast cancer of a subject. Additionally, methods of recommending treatment for a subject that has breast cancer are provided. Further provided are methods of treating a subject that has breast cancer. Systems for performing described methods are also provided.
    Type: Application
    Filed: November 11, 2016
    Publication date: May 18, 2017
    Inventors: Yi Zhang, Catherine A. Schnabel
  • Publication number: 20170137892
    Abstract: The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived exosomes isolated from a biological sample from the subject.
    Type: Application
    Filed: December 16, 2016
    Publication date: May 18, 2017
    Inventors: Douglas D. Taylor, Cicek Gercel-Taylor
  • Publication number: 20170137893
    Abstract: The disclosure concerns a prognostic method for determining at least one, or a combination, of the following: time to first treatment, response to treatment or overall survival for a patient presenting with a disease including or characterised by telomere shortening, including an assessment of the longest mean telomere length at which telomere end-end fusion events can be detected and then a determination of the mean telomere length in the fusogenic range (i.e. the range below that mean telomere length at which telomere end-end fusion events can be detected) and the subsequent use of the mean telomere length in the fusogenic range as a prognostic indicator.
    Type: Application
    Filed: January 30, 2017
    Publication date: May 18, 2017
    Inventors: Duncan Baird, Chris Pepper, Christopher Fegan
  • Publication number: 20170137894
    Abstract: Provided are oligonucleotides that are capable of detecting KRAS and PIK3CA mutations in both cancer patients and healthy individuals with high specificity in kPCR assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of KRAS codon 12, 13, and 61 and PIK3CA codon 542, 545, and 1047 single nucleotide polymorphisms (SNPs) in a background of wild-type sequences. The oligonucleotides of the present invention are also capable of preventing pseudogene amplification when the oligonucleotides are hybridized as reverse primers or detection probes to the mismatch sequences.
    Type: Application
    Filed: January 31, 2017
    Publication date: May 18, 2017
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jill Detmer, Arejas J. Uzgiris, Andy Ying
  • Publication number: 20170137895
    Abstract: The invention provides a method of identifying a microorganism that expresses a nucleic acid-modifying enzyme, in sample, the method comprising: (a) contacting a nucleic acid substrate targeted by the nucleic acid-modifying enzyme with the sample; (b) adding a further nucleic acid molecule to the sample which nucleic acid molecule is ligated to the nucleic acid substrate in the presence of the nucleic acid-modifying enzyme to form a ligation product which comprises a linear single strand of nucleic acid that is capable of being detected; and (c) detecting the presence of the ligation product.
    Type: Application
    Filed: May 15, 2015
    Publication date: May 18, 2017
    Inventors: Magnus Stougaard, Birgitta Ruth Knudsen, Marianne Smedegaard Hede, Jonas Thomsen, Yi-Ping Ho
  • Publication number: 20170137896
    Abstract: The invention relates to a method of identifying a specific yeast species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the yeast species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the yeast species, and specifically identifying the yeast species. The invention also relates to a method of identifying a yeast mycotoxin in patient tissue or body fluid. The method comprises the steps of extracting and recovering the yeast mycotoxin from the patient tissue or body fluid, contacting the yeast mycotoxin with an antibody directed against the yeast mycotoxin, and identifying the yeast myocotoxin. Both of these methods can he used to determine if a patient is at risk for or has developed a disease state related to a yeast infection, and to develop an effective treatment regimen for the patient.
    Type: Application
    Filed: October 12, 2016
    Publication date: May 18, 2017
    Inventor: Dennis G. Hooper
  • Publication number: 20170137897
    Abstract: The present invention relates to a method for determining the genotype of a Cruciferous vegetable plant for a plant with an increased glucosinolate level, comprising obtaining a sample of nucleic acids from said plant or a portion thereof and detecting in said nucleic acids a polymorphism at the Myb28 locus that is genetically linked to an increased glucosinolate level.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Richard F. Mithen, Maria Traka, Bart W. Brugmans
  • Publication number: 20170137898
    Abstract: Disclosed herein are various methods, systems, and compositions for the growth independent detection of cells such as microorganisms including bacteria. While existing cellular detection methodologies benefit from cell growth, the methods, systems, and compositions disclosed herein demonstrate embodiments that are independent of cell growth while still allowing for cell-based detection.
    Type: Application
    Filed: November 29, 2016
    Publication date: May 18, 2017
    Inventor: Diego Ariel Rey
  • Publication number: 20170137899
    Abstract: Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences.
    Type: Application
    Filed: January 12, 2017
    Publication date: May 18, 2017
    Applicant: Erasmus University Medical Center Rotterdam
    Inventors: Ronaldus Adrianus Maria Fouchier, Bernadetta Gerarda Van Den Hoogen, Albertus Dominicus Marcellinus Erasmus Osterhaus, Jan Cornelius De Jong, Jan Groen
  • Publication number: 20170137900
    Abstract: The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with the AIDS causing Human Immuno-deficiency Virus (HIV). With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of HIV-1 nucleic acid. The oligonucleotide sequences provided with the present invention are located in the LTR part of the HIV viral genome. It has been found that, by using the sequences of the present invention in methods for the amplification and detection of nucleic acid a sensitive and specific detection of HIV-1 can be obtained. The benefit of the sequences of the present invention primarily resides in the fact that, with the aid of primers and probes comprising the sequences according to the invention the nucleic acid of all presently known subtypes of HIV-1 can be detected with high accuracy and sensitivity.
    Type: Application
    Filed: December 14, 2016
    Publication date: May 18, 2017
    Inventors: Jaap Goudsmit, Pieter Oudshoorn, Suzanne Jurriaans, Vladimir Vladimirovich Lukashov
  • Publication number: 20170137901
    Abstract: The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of HCV, in particular regions that encode the NS3 polypeptide. In some embodiments the primers are used in nested PCR methods for the detection or sequencing of HCV NS3. The oligonucleotide sequences are also provided assembled as kits that can be used to amplify and detect or sequence HCV NS3.
    Type: Application
    Filed: December 1, 2016
    Publication date: May 18, 2017
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Arejas Uzgiris, Sunil Pandit, Lance Palmer
  • Publication number: 20170137902
    Abstract: A major object of the present invention is to provide an effective means for promoting polyamine synthesis in an organism (in particular, in humans). Lactobacillus paracasei having polyamine production promoting activity in an organism.
    Type: Application
    Filed: March 23, 2015
    Publication date: May 18, 2017
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Takeshi IKENAGA, Tsuneyuki NODA, Yoshito TAJIRI, Hiroki NOGUCHI, Atsushi UEDA, Noriyuki KOUDA
  • Publication number: 20170137903
    Abstract: A sulfonatocalixarene tanning agent for leather tanning and a preparation method comprises: using resorcinol and aldehyde monomers as raw materials for the tanning agent; adding an ethanol solution into the resorcinol, dropwise adding an inorganic strong acid catalyst and aldehyde derivatives, heating to react, cooling, carrying out suction filtration, repeatedly washing with ethanol and distilled water, and drying to obtain resorcinol calixarene; and weighing the resorcinol calixarene, and adding a sulfonating agent to react, thereby obtaining a sulfonatocalixarene tanning agent aqueous solution.
    Type: Application
    Filed: June 18, 2015
    Publication date: May 18, 2017
    Applicant: SHAANXI UNIVERSITY OF SCIENCE & TECHNOLOGY
    Inventors: Jianzhong MA, Yongxiang ZHOU, Dangge GAO, Panpan ZHANG, Bin LV
  • Publication number: 20170137904
    Abstract: A rolled steel bar for machine structural use includes a predetermined chemical composition. In the rolled steel bar for machine structural use, K1 obtained from “K1=C+Si/7+Mn/5+1.54×V” is 0.95 to 1.05, K2 obtained from “K2=139?28.6×Si+105×Mn?833×S?13420×N” is more than 35, K3 obtained from “K3=137×C?44.0×Si” is 10.7 or more, a Mn content and a S content satisfy Mn/S?8.0, and a total decarburized depth in a surface layer is 500 ?m or less.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Hiromasa TAKADA, Shinya TERAMOTO, Osamu OHYAMA
  • Publication number: 20170137905
    Abstract: A high-tensile-strength steel plate is provided with a new chemical composition design that guarantees the same properties as a 50 mm thick steel plate even in a steel plate with a thickness of 100 mm or greater, without the yield stress being affected by the plate thickness. By mass %, the chemical composition includes C: 0.02% to 0.08%, Si: 0.01% to 0.35%, Mn: 1.4% to 2.0%, P: 0.007% or less, S: 0.0035% or less, Al: 0.010% to 0.060%, Ni: 0.5% to 2.0%, Mo: 0.10% to 0.50%, Nb: 0.005% to 0.040%, Ti: 0.005% to 0.025%, B: less than 0.0003%, N: 0.002% to 0.005%, Ca: 0.0005% to 0.0050%, and O: 0.003% or less, with the components additionally satisfying a predetermined relationship.
    Type: Application
    Filed: March 31, 2015
    Publication date: May 18, 2017
    Applicant: JFE STEEL CORPORATION
    Inventors: Katsuyuki Ichimiya, Masao Yuga, Kazukuni Hase, Shigeru Endo
  • Publication number: 20170137906
    Abstract: The invention deals with a cold rolled and hot dip steel sheet, with a tensile strength of at least 980 MPa, with yield strength above or equal to 500 MPa, with total elongation above or equal to 8%, the composition consisting by weight percent: 0.05<C<0.15%, 2<Mn?3%, Al<0.1%, 0.3<Si<1.5%, 0.01%<Nb<0.05%, N<0.02%, 0.1<Cr+Mo<1%, 0.0001<B<0.0025, Ti<0.5%, V<0.01%, S<0.01%, P<0.05% the remainder of the composition being iron and unavoidable impurities resulting from the smelting and the microstructure contains, in surface fraction: between 50 and 95% of martensite and between 5 and 50% of the sum of ferrite and bainite, wherein the ferrite grain size is below 10????, and wherein the aspect ratio of the ferrite grain size is between 1 and 3. The steel according to the invention is oxidized and subsequently reduced during heating, soaking and cooling steps of the annealing.
    Type: Application
    Filed: June 3, 2015
    Publication date: May 18, 2017
    Inventors: Dongwei Fan, Hyun Jo Jun, John A. Rotole
  • Publication number: 20170137907
    Abstract: A method for producing a high strength steel sheet having a yield strength YS>850 MPa, a tensile strength TS>1180 MPa, a total elongation >13% and a hole expansion ratio HER>30%, by heat treating a steel sheet wherein the chemical composition of the steel contains: 0.13%?C?0.22%, 1.2%?Si?1.8%, 1.8%?Mn?2.2%, 0.10%?Mo?0.20%, Nb?0.05%, Ti<0.05%, Al?0.5%, the remainder being Fe and unavoidable impurities. The sheet is annealed at an annealing temperature TA>865° C. and <1000° C. for a time of more than 30 s, then quenched by cooling it to a quenching temperature QT between 275° C. and 375° C., at a cooling speed >30° C./s in order to have, just after quenching, a structure consisting of austenite and at least 50% of martensite, the austenite content being such that the final structure can contain between 3% and 15% of residual austenite and between 85% and 97% of the sum of martensite and bainite without ferrite, then heated to a partitioning temperature PT between 370° C. and 470° C.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Inventors: Rashmi Ranjan Mohanty, Hyun Jo Jun, Dongwei Fan, Pavan K.C. Venkatasurya
  • Publication number: 20170137908
    Abstract: A method for producing a high strength coated steel sheet having an improved ductility and an improved formability, the chemical composition of the steel containing: 0.13%?C?0.22%, 1.9%?Si?2.3%, 2.4%?Mn?3%, Al?0.5%, Ti<0.05%, Nb<0.05%, the remainder being Fe and unavoidable impurities. The sheet is annealed at temperature TA higher than Ac3 but less than 1000° C. for a time of more than 30 s, quenched by cooling to a quenching temperature QT between 200° C. and 280° C. in order to obtain a structure consisting of austenite and at least 50% of martensite, the austenite content being such that the final structure can contain between 3% and 15% of residual austenite and between 85% and 97% of the sum of martensite and bainite, without ferrite, heated up to a partitioning temperature PT between 430° C. and 490° C. and maintained at this temperature for a time Pt between 10 s and 100 s, hot dip coated and cooled to the room temperature.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Inventors: Dongwei Fan, Hyun Jo Jun, Rashmi Ranjan Mohanty, Pavan K.C. Venkatasurya
  • Publication number: 20170137909
    Abstract: A method for manufacturing a high-strength steel sheet having a tensile strength of more than 1100 MPa and a yield strength of more than 700 MPa, a uniform elongation UE of at least 8.0% and a total elongation of at least 10%, made of a steel containing in percent by weight: 0.1%?C?0.25%, 4.5%?Mn?10%, 1%?Si?3%, 0.03%?Al?2.5%, the remainder being Fe and impurities resulting from the smelting, the composition being such that CMn Index=Cx(1+Mn/3.5)?0.6, the method comprising the steps of annealing a rolled sheet made of said steel by soaking it at an annealing temperature TA higher than the Ac transformation point of the steel but less than 1000° C., cooling the annealed sheet to a quenching temperature QT between 190° C. and 80° C. at a cooling speed sufficient to obtain a structure just after cooling containing martensite and retained austenite, maintaining the steel sheet at an overaging temperature PT between 350° C. and 500° C.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Inventors: Wei Xu, Artem Arlazarov
  • Publication number: 20170137910
    Abstract: A method for producing a cold rolled steel sheet having a tensile strength?1470 MPa and a total elongation TE?19%, the method comprising the steps of annealing at an annealing temperature AT?Ac3 a non-treated steel sheet whose chemical composition contains in weight %: 0.34%?C?0.40%, 1.50%?Mn?2.30%, 1.50?Si?2.40%, 0%?Cr?0.7%, 0%?Mo?0.3%, 0.01%?Al?0.07%, the remainder being Fe and unavoidable impurities, quenching the annealed steel sheet by cooling it to a quenching temperature QT<Ms transformation point and between 150° C. and 250° C., and making a partitioning treatment by re-heating the quenched steel sheet to a partitioning temperature PT between 350° C. and 420° C. and maintaining the steel sheet at this temperature during a partitioning time Pt between 15 seconds and 250 seconds.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Inventors: Olga A. Girina, Damon Panahi
  • Publication number: 20170137911
    Abstract: Methods for producing flat steel product with a yield strength of at least 700 MPa and an at least 70% by volume bainitic microstructure may comprise several steps. For example, one method may involve smelting a steel melt including in percent by weight 0.05-0.08% C, 0.015-0.500% Si, 1.60-2.00% Mn, 0.025% P, up to 0.010% S, 0.020-0.050% Al, up to 0.006% N, 0.40% Cr, 0.060-0.070% Nb, 0.0005-0.0025% B, 0.090-0.130% Ti, unavoidable impurities, and Fe. The may further involve casting the melt to give a slab, reheating the slab, rough-rolling the slab, hot finish-rolling the rough-rolled slab, cooling the hot-finish-rolled flat steel product within ten seconds of hot finish-rolling, and coiling the hot-finish-rolled flat steel product.
    Type: Application
    Filed: March 18, 2015
    Publication date: May 18, 2017
    Applicants: ThyssenKrupp Steel Europe AG, ThyssenKrupp AG
    Inventors: Alexander Gaganov, Wolfgang Gervers, Andreas Kern, Gabriel Kolek, Elena Schaffnit, Hans Joachim Tschersich
  • Publication number: 20170137912
    Abstract: A process for producing substantially dry slag granules comprises adding a controlled amount of water to a molten stream of slag, and granulating the slag to produce solidified slag comprising substantially dry slag granules and slag wool. An apparatus for producing substantially dry slag granules comprises: (a) an inclined surface having an upper and lower ends for receiving and discharging the stream of slag; (b) a dispersion device at the lower end of the inclined surface for dispersion of the molten slag; (c) one or more water addition devices for adding a controlled amount of water to the molten slag; and (d) a collection area adjacent to the dispersion device for deposition of solidified slag produced by the dispersion. The quantity of slag wool produced by the process and apparatus is less than that which would be produced without the addition of water.
    Type: Application
    Filed: March 20, 2015
    Publication date: May 18, 2017
    Inventors: Santiago Faucher, Sang-Yoon Oh, Sina Mostaghel, Lai Chi So, Victor Hernandez, Maurizio Darini, Darryl Robert Metcalfe, Tom Rafferty
  • Publication number: 20170137913
    Abstract: The invention relates to processes for separating metals, and in particular for separating precious metals such as platinum and palladium, by solvent extraction. The invention also provides novel solvent extraction mixtures useful in the processes of the invention. The inventors have found that by simultaneously employing different extraction mechanisms for the extraction of a plurality of different metals, a simple and convenient process for their separation can be achieved. In particular, the inventors have found that the use of different extraction mechanisms for simultaneously extracting metals from an aqueous acidic phase into an organic phase enables the extracted metals to be separated by selective stripping from the organic phase using simple and mild conditions. This process is particularly advantageous as it permits two or more metals to be separated following a single solvent extraction step, because of the ability to selectively strip the metals from the organic phase.
    Type: Application
    Filed: June 16, 2015
    Publication date: May 18, 2017
    Inventors: Ross John GORDON, Richard Alasdair GRANT
  • Publication number: 20170137914
    Abstract: Disclosed is selective removal of mercury from aqueous feeds also including precious metals. In particular, the present invention is useful for removal of mercury from processing waters produced during precious metal mining processes. The process includes contacting the aqueous feed solution with a solid sorbent material including thiol and/or thiolate functional groups, wherein (i) the aqueous feed solution includes at least 10 ppm of free cyanide ions; and/or (ii) the sorbent material is contacted with an aqueous cyanide solution after contact with the aqueous feed solution to selectively desorb precious metal from the sorbent material.
    Type: Application
    Filed: March 31, 2015
    Publication date: May 18, 2017
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventor: James George STEVENS
  • Publication number: 20170137915
    Abstract: An object of the present invention is to provide a method for recovering a rare earth element, including subjecting a workpiece containing at least a rare earth element and an iron group element to an oxidation treatment, then turning the treatment environment into an environment where carbon is present, and subjecting an oxidation-treated workpiece to a heat treatment, thereby separating a rare earth element in the form of an oxide from an iron group element, according to which an oxide of a rare earth element can be efficiently separated from an iron group element at low treatment cost, and also wear and damage to the treatment container can be suppressed to allow the container to be used repeatedly for a long period of time.
    Type: Application
    Filed: March 26, 2015
    Publication date: May 18, 2017
    Applicant: HITACHI METALS, LTD.
    Inventors: Hiroyuki HOSHI, Yu MIYAMOTO
  • Publication number: 20170137916
    Abstract: The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support comprising a leaching treatment of the 226Ra-targets for leaching essentially for the entirety of 223Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotops and a second extraction chromotography for separating 223Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Josue Manuel MORENO BERMUDEZ, Andreas TURLER, Richard HENKELMANN, Eva KABAI, Ernst HUENGES
  • Publication number: 20170137917
    Abstract: The present invention belongs to the technical field of the preparation of alloy materials, and discloses a high strength and toughness alloy material, a method for preparing the alloy material by semi-solid sintering, and application thereof.
    Type: Application
    Filed: December 29, 2015
    Publication date: May 18, 2017
    Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Chao YANG, Yaguang YAO, Limei KANG, Lehua LIU, Shengguan QU, Weiping CHEN, Yuanyuan LI
  • Publication number: 20170137918
    Abstract: The present invention relates to an aluminium alloy and a process of producing the same, wherein the aluminium alloy comprises Al, Si, Fe, Mg, Cu, Ti and optionally other impurities, characterized in that the components are comprised in amounts by weight of: Si: 0.04-0.1%, Fe: 0.2-0.4%, Mg: 0.055-0.12%, Cu: 0.004-0.01%, Ti: 0.003-0.02%; any one of the other impurities is in an amount by weight of no more than 0.03%; and the balance is Al. The present invention also relates an article comprising the aluminium alloy, the use of the aluminium alloy article for printing plate, and a process of producing an aluminium alloy sheet/strip/foil for printing plate using the aluminium alloy.
    Type: Application
    Filed: August 13, 2014
    Publication date: May 18, 2017
    Inventors: Syewai CHAN, Jianguo WANG, Xiguang WANG, Jianlin NING, Li SHU, Bin YANG
  • Publication number: 20170137919
    Abstract: Aluminum alloy material containing Si: 1.0 to 5.0 mass % and Fe: 0.01 to 2.0 mass % with balance being Al and inevitable impurities, wherein 250 pcs/mm2 or more to 7×105 pcs/mm2 or less of Si-based intermetallic compound particles having equivalent circle diameters of 0.5 to 5 ?m are present in a cross-section of the aluminum alloy material, while 100 pcs/mm2 or more to 7×105 pcs/mm2 or less of Al-based intermetallic compound particles having equivalent circle diameters of 0.5 to 5 ?m are present in a cross-section of the aluminum alloy material. An aluminum alloy structure is manufactured by bonding two or more members in vacuum or a non-oxidizing atmosphere at temperature at which a ratio of a mass of a liquid phase generated in the aluminum alloy material to a total mass of the aluminum alloy material is 5% or more and 35% or less.
    Type: Application
    Filed: January 20, 2017
    Publication date: May 18, 2017
    Inventors: Akio NIIKURA, Kazuko FUJITA, Takashi MURASE, Yoshiyuki OYA, Tomohito KUROSAKI
  • Publication number: 20170137920
    Abstract: New magnesium-zinc aluminum alloy bodies and methods of producing the same are disclosed. The new magnesium-zinc aluminum alloy bodies generally include 3.0-6.0 wt. % magnesium and 2.5-5.0 wt. % zinc, where at least one of the magnesium and the zinc is the predominate alloying element of the aluminum alloy bodies other than aluminum, and wherein (wt. % Mg)/(wt. % Zn) is from 0.6 to 2.40, and may be produced by preparing the aluminum alloy body for post-solutionizing cold work, cold working by at least 25%, and then thermally treating. The new magnesium-zinc aluminum alloy bodies may realize improved strength and other properties.
    Type: Application
    Filed: January 30, 2017
    Publication date: May 18, 2017
    Inventors: Jen C. Lin, John M. Newman, Ralph R. Sawtell, Rajeev G. Kamat, Darl G. Boysel, Gary H. Bray, James Daniel Bryant, Brett P. Connor, Mario Greco, Gino Norman Iasella, David J. McNeish, Shawn J. Murtha, Roberto J. Rioja, Shawn P. Sullivan
  • Publication number: 20170137921
    Abstract: Described herein are systems and methods for producing a hardwearing or wear-resistant alloy steel. In one aspect, a first group of materials comprising steel may be heated, and melted to liquid form. The melted first group may then be mixed with a second group of materials comprising carbon, chromium, nickel, manganese, silicon, molybdenum, titanium, rhenium, sulfur, and phosphorus, to yield a mixture. The mixture may then be cast, cooled, and heat-treated to yield the hardwearing or wear-resistant alloy steel.
    Type: Application
    Filed: February 28, 2016
    Publication date: May 18, 2017
    Inventor: Yuanji Zhu
  • Publication number: 20170137922
    Abstract: The invention relates to a method for the production of a mechanical part, comprising the following successive steps: casting of a billet of aluminium alloy with a composition (in weight %) of 0.4-3.0 Si; 0.6-2.0 Mg; 0.20-1.0 Cu; 0.15-1.8 Fe; Mn<0.5; Ni<1; Ti<0.15; Cr<0.35; Bi<0.8; Pb<0.4; Zr<0.04; other elements <0.05 each and <0.
    Type: Application
    Filed: March 20, 2015
    Publication date: May 18, 2017
    Inventors: Lukasz DOLEGA, Jean-sylvestre SAFRANY, Ivo KOLARIK
  • Publication number: 20170137923
    Abstract: Provided is a technique in which a reduction annealing method is used to efficiently produce a high-strength hot-dip galvanizing substrate or high-strength hot-dip galvannealing substrate, which is useful as a raw material for producing a high-strength plated steel sheet suppressed in the occurrence of bare spot. The substrate for hot-dip galvanizing or hot-dip galvannealing of the present invention satisfies the following condition: when the mapping intensity of Fe, which is obtained by using an electron probe microanalyser in a measurement field of view of 33.6 ?m× 41.4 ?M on the surface after reduction annealing, of 0 to 240 is divided into 16 parts at an interval of 15, the area occupied by a mapping intensity of 195 or more has 70% or more.
    Type: Application
    Filed: August 11, 2015
    Publication date: May 18, 2017
    Applicant: Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.)
    Inventors: Minoru CHIDA, Hiroshi IRIE
  • Publication number: 20170137924
    Abstract: An internal member for an apparatus of depositing a conductive thin film includes a chamber structure including a object supporting unit supporting an object on which the conductive thin film is to be deposited, and a target supporting unit supporting a target for depositing the conductive thin film on the object, wherein the target including a first metal material the chamber structure having a reaction space therein and a coating structure formed on an inner surface of the chamber structure, the inner surface being indirectly exposed to the reaction space of the chamber structure via the coating structure, and the coating structure including a second metal material having at least one metal element in the first metal material.
    Type: Application
    Filed: June 4, 2015
    Publication date: May 18, 2017
    Applicant: KOMICO CO., LTD.
    Inventors: Sung Soo JANG, Hyun Chul KO, Kyung Ic JANG, Sung Jin CHOI
  • Publication number: 20170137925
    Abstract: Presented is a method, apparatus, and computer-readable medium for carburization. A method includes creating a vacuum within an interior of a chamber, the interior of the chamber including an item, the item having a first portion and a second portion, and providing an inert gas and a carbon product to the interior of the chamber. The method further including heating by induction the first portion of the item to induce carburization of the first portion of the item, and in response to the heating, cooling a second portion of the item such that the second portion of the item maintains its structural integrity.
    Type: Application
    Filed: November 17, 2015
    Publication date: May 18, 2017
    Inventors: Walter G. Leach, JR., Peter Michael Costantino, Scott McAllister, Dale Wilcox