Patents Issued in May 30, 2017
  • Patent number: 9662399
    Abstract: Disclosed in certain embodiments is a solid oral dosage form comprising a heat-labile gelling agent; a thermal stabilizer; and a drug susceptible to abuse.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 30, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Debora Guido, Haiyong Hugh Huang
  • Patent number: 9662400
    Abstract: The invention provides improved methods for generating biodegradable chitosan compositions, and therapeutic methods of using such compositions to deliver therapeutic agents.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 30, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: James Keaton Smith, Ashley C. Parker, Jessica A. Jennings, Benjamin T. Reves, Warren O. Haggard
  • Patent number: 9662401
    Abstract: This invention encompasses targeting-enhanced anticancer nanoparticles and preparation methods for the same. In particular, this invention provides targeting-enhanced anticancer nanoparticles comprising non-covalently bound anticancer drugs, serum albumins as the nanoparticle base material, and porphyrin compounds as tumor-targeting moieties. The targeting-enhanced anticancer nanoparticles described in the present invention are characterized by non-covalently bound constituents: anticancer drugs, serum albumin as the nanoparticle base material, and porphyrin compounds as tumor-targeting moieties, thus preventing common toxic side effects, enhancing the structural stability of nanoparticles, and enhancing tumor targeting by treatment with electromagnetic waves due to the activity of porphyrin, without structural and functional changes.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: May 30, 2017
    Assignee: JINIS CO., LTD.
    Inventors: Hyeon Jin Kim, Seong Tshool Hong, Hea Jong Chung, Min Kyu Joo, Hea Guk Cho, Jinny Hong
  • Patent number: 9662402
    Abstract: Described herein are drug delivery conjugates for targeted therapy. In particular, described herein are drug delivery conjugates that include polyvalent linkers comprising one or more unnatural amino acids that are useful for treating cancers and inflammatory diseases. The invention described herein pertains to drug delivery conjugates for targeted therapy. In particular, the invention described herein pertains to drug delivery conjugates that include polyvalent linkers comprising one or more unnatural amino acids.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: May 30, 2017
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon
  • Patent number: 9662403
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: May 30, 2017
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Patent number: 9662404
    Abstract: The present disclosure provides methods and compositions related to the cytosolic delivery of proteins and cell-impermeable small molecules into live cells using an endosomolytic dimer of cell-penetrating peptide TAT.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: May 30, 2017
    Assignee: The Texas A&M University System
    Inventor: Jean-Philippe Pellois
  • Patent number: 9662405
    Abstract: Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: May 30, 2017
    Assignee: Thomas Jefferson University
    Inventors: Scott A. Waldman, Michael S. Magee, Adam E. Snook
  • Patent number: 9662406
    Abstract: The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: May 30, 2017
    Assignee: University of Virginia Patent Foundation
    Inventors: Robert Hendel, William B. Stilley, Shannon P. Williams
  • Patent number: 9662407
    Abstract: This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: May 30, 2017
    Assignee: TRANSLATUM MEDICUS INC.
    Inventor: Shelley Romayne Boyd
  • Patent number: 9662408
    Abstract: The present invention relates to a fiducial marker comprising barium sulfate (BaSO4), a solvent, and a polyethylene glycol-poly(aminourethaneurea) multi-block copolymer, as active ingredients. The fiducial marker of the present invention has an effect of significantly remedying disadvantages of image distortion and dose distortion, which are involved in the gold inner marker used in the conventional art. The fiducial marker of the present invention has very limited in vivo mobility, and thus the fiducial marker is maintained at the position at which it has been initially injected. Since the fiducial marker of the present invention is maintained in a sol or liquid state before in vivo injection, and transited into a gel or solid phase after in vivo injection, the injectability of the fiducial marker by an injector syringe is favorable, and the state of the fiducial marker can be controlled into a phase suitable to each site of the therapeutic target.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: May 30, 2017
    Assignees: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION, RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
    Inventors: Young Yih Han, Hee Chul Park, Doo Sung Lee, Jae Myoung Noh, Sang Hee Ahn, Hye Young Kim, Moon Soo Gil
  • Patent number: 9662409
    Abstract: A lighting device includes a first light source configured to generate light for illumination of a space and a second light source configured to generate light of a particular wavelength independently from the first light source. The light generated by the second light source is output at a sufficient intensity so as to reasonably expect to support an intended benefit other than illumination of the space. The first light source and the second light source are integrated into the same lighting device. The lighting device includes an optical element coupled to the first and second light sources that is configured to produce a light output of the lighting device. The lighting device outputs the light for illumination of the space and the light of the particular wavelength for the other intended benefit from the second light source via the same output of the lighting device.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: May 30, 2017
    Assignee: ABL IP Holding LLC
    Inventors: Jack C. Rains, Jr., David P. Ramer, Januk Aggarwal
  • Patent number: 9662410
    Abstract: A system for sanitizing a tray table may include a sanitation assembly operatively coupled to the tray table. The sanitation assembly includes an ultraviolet (UV) light source configured to emit UV light, and a sanitation control unit operatively coupled to the UV light source. The sanitation control unit operates the UV light source to emit the UV light onto the tray table when the tray table is secured in an upright position, and prevents the UV light source from emitting the UV light when the tray table is not secured in the upright position.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: May 30, 2017
    Assignee: The Boeing Company
    Inventor: Steven George Mackin
  • Patent number: 9662411
    Abstract: Sterilization units and systems and related assemblies, devices, and methods are disclosed. The sterilization units may be mobile and used in a variety of locations. The sterilization units and systems use germicidal ultraviolet-C light to kill or render non-viable bacteria and viruses. The various sterilization units and systems disclosed herein may have improved ultraviolet light distribution and/or improved ability to direct and focus the ultraviolet light in a desired area. The sterilization units and systems may optionally be made of non-magnetic materials such that the sterilization units and systems may be used in the vicinity of MRI equipment without causing complications or damage to the MRI equipment.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: May 30, 2017
    Inventor: Alan Rizzone
  • Patent number: 9662412
    Abstract: Exemplary apparatuses and methods of killing or deactivating bacteria are disclosed herein. An exemplary apparatus for killing or deactivating bacteria includes a plasma vapor chamber. The plasma vapor chamber has a vapor inlet for allowing a vapor into the chamber, a high voltage electrode, one or more grounding electrodes. The one or more grounding electrodes at least partially surrounding the plasma vapor chamber. The plasma vapor chamber includes an outlet for allowing fluid to flow out of the chamber. When the chamber is filled with vapor for a period of time sufficient to saturate the chamber with vapor, the high voltage electrode is energized to generate plasma throughout the chamber.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: May 30, 2017
    Assignee: EP Technologies LLC
    Inventors: James Ferrell, Erinn R. Bogovich, Robert L. Gray, Daphne Pappas Antonakas, Tsung-Chan Tsai, Sameer Kalghatgi
  • Patent number: 9662413
    Abstract: A method for dispensing an active volatile in the environment surrounding a surface, which comprises applying to the surface a self-adhering, water-resistant gel composition of at least one active volatile ingredient, silica, and a water-soluble cationic polysaccharide, and diffusing or releasing the volatile ingredient(s) from the gel in an amount sufficient to purify or sanitize the surrounding air, both in a dry condition or in the presence of humidity or water. The gel composition remains adhered to the surface and actively releases the volatile ingredient(s) even after being exposed to repeated water flows over the composition.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: May 30, 2017
    Assignee: FIRMENICH SA
    Inventors: Simon Hurry, Jane Summers
  • Patent number: 9662414
    Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: May 30, 2017
    Assignees: First Water Limited, Queen Mary University of London, Edixomed Limited
    Inventors: Christopher Barry Wood, Hugh Semple Munro, Nicholas David Boote, Joanne Ellen Stewart, Arthur Tudor Tucker
  • Patent number: 9662415
    Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: May 30, 2017
    Assignee: WORCESTER POLYTECHNIC INSTITUTE
    Inventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
  • Patent number: 9662416
    Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: May 30, 2017
    Assignee: OrbusNeich Medical, Inc.
    Inventors: G. Lawrence Thatcher, Robert J. Cottone
  • Patent number: 9662417
    Abstract: The invention is directed to an improved medical device. In particular, the invention is directed to an improved medical device having a coating comprising novel cellular factor-containing solution compositions (referred to herein as CFS compositions), such CFS compositions including conditioned medium compositions obtained from culturing extraembryonic cytokine secreting cells (ECS cells), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) obtained from culturing Amnion-derived Multipotent Progenitor (AMP) cells, dispersed in a polymeric coating material.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: May 30, 2017
    Assignee: STEMNION, INC.
    Inventors: Larry R Brown, George L Sing
  • Patent number: 9662418
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: May 30, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9662419
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 30, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9662420
    Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 30, 2017
    Assignee: Cornell University
    Inventors: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard
  • Patent number: 9662421
    Abstract: The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 30, 2017
    Assignee: NOV AHEP AB
    Inventors: Suchitra Sumitran-Holgersson, Michael Olausson
  • Patent number: 9662422
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 30, 2017
    Assignee: Allergan, Inc.
    Inventors: Jacob F. Pollock, Lauren E. Kokai, Cunqi Cui, Xiaojie Yu, Dennis E. Van Epps, Darin J. Messina
  • Patent number: 9662423
    Abstract: Methods for the deposition of silver-comprising films on nonconducting substrates, and, more particularly, to deposition of such films that are very thin, are provided. The surface of nonconducting substrates is modified with a superabsorbent polymer to increase silver deposition when compared to a non-modified surface. Also provided are films produced using a swelling agent, whereby porosity of the surface of the nonconducting substrate is increased, thereby permitting increased silver deposition when compared to an unmodified surface.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: May 30, 2017
    Assignee: C. R. Bard, Inc.
    Inventors: Richard Terry, Fungbor Chen, Zhihui Yin
  • Patent number: 9662424
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: May 30, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Patent number: 9662425
    Abstract: A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60° C. to about 100° C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 30, 2017
    Assignee: Stryker European Holdings I, LLC
    Inventors: Mirjam Lilja, Jan Henrik Sörensen, Philip Procter, Hartwig Steckel, Torben Christian Sörensen
  • Patent number: 9662426
    Abstract: A medical waste fluid collection and disposal system includes a medical waste fluid collection cart including first and second fluid collection canisters. A valve assembly selectively communicates with the canisters and a valve drive system controls the valve assembly. A liquid level sensor is positioned within each of the canisters. A cart processor communicates with the liquid level sensors and the valve drive system. A cart drain line communicates with the valve assembly and a receptacle, a cart flushing line communicates with the valve assembly and the receptacle and a cart data line and a cart power line communicate with the cart processor and the cart receptacle. A station includes a drain pump that communicates with a drainage system and a station drain line, a flushing pump that communicates with a source of washing liquid and a station flushing line and a station processor in communication with the drain and flushing pumps. A station data line communicates with the station processor.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: May 30, 2017
    Assignee: Dornoch Medical Systems, Inc.
    Inventors: Anthony Martini, Lawrence Guerra
  • Patent number: 9662427
    Abstract: Dressings, systems, and methods are disclosed that, in some embodiments, relate to treating a tissue site. In one embodiment, a dressing may include a manifold, a retention pouch, a sealing member, and a conduit interface. The manifold may be adapted to distribute reduced pressure to the tissue site, and the retention pouch may be adapted to retain and manage fluid extracted from the tissue site. The sealing member may cover the retention pouch and the manifold to provide a sealed space with the tissue site. The conduit interface may be in fluid communication with the sealed space and an exterior surface of the sealing member. The dressing may be utilized with a therapy device operable to control reduced pressure in the dressing and fluid flow over the sealing member.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: May 30, 2017
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Richard Daniel John Coulthard, Benjamin A. Pratt, Timothy Mark Robinson
  • Patent number: 9662428
    Abstract: A system and method for regenerating damaged or necrosed tissue. Negative or vacuum pressure is applied to a surface of the damaged tissue to stimulate the revascularization of the area and/or increased blood flow to the area, which encourages the regeneration of the damaged tissue. A negative pressure device is provided that is capable of providing a sequenced vacuum treatment regimen to damaged tissue.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 30, 2017
    Assignee: RAPTOR RIDGE, LLC
    Inventor: William K. Wheeler
  • Patent number: 9662429
    Abstract: An apparatus and system for fluidly connecting a reduced-pressure source to a dressing and a method for manufacturing and using the same include a base having an aperture and a wall having a peripheral portion coupled to the base. The wall may form a cavity in fluid communication with the aperture. The apparatus also may include a conduit port fluidly coupled to the cavity and adapted to receive a conduit. The base may be adapted to couple to the dressing, and the wall may be adapted to collapse from a first position to a second position in response to a supply of reduced pressure from the reduced-pressure source.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: May 30, 2017
    Assignee: KCI Licensing, Inc.
    Inventors: Benjamin Andrew Pratt, Christopher Brian Locke
  • Patent number: 9662430
    Abstract: The invention relates to a device and a method for conveying a fluid to a filter unit of a medical treatment apparatus, in particular for conveying a dialysing fluid to a treatment unit, in particular a dialyser or filter of an extracorporeal blood treatment apparatus. The device comprises a balancing unit and a recirculation unit, which comprises one or more chambers. With the balancing unit, it is possible to supply fresh fluid continuously to the recirculation circuit and to discharge used fluid from the recirculation circuit. The supply and discharge of fresh and used dialysing fluid can take place at a flow rate other than the flow rate at which the fluid circulates in the recirculation circuit via the filter unit.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: May 30, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Stefan Kreber, Manfred Weis
  • Patent number: 9662431
    Abstract: The present invention relates to a rotary blood pump with a double pivot contact bearing system with an operating range between about 50 mL/min and about 1500 mL/min. The rotary blood pump is part of a blood pump system that includes blood conduit(s), a control system with optional sensors, and a power source. Embodiments of the present invention may include elements such as wear resistant bearing materials, a rotor back plate for magnetic attraction of the rotor to reduce bearing pivot bearing forces and wear, a rotor size and shape and a bearing gap that combine to create a hydrodynamic bearing effect and reduce bearing pivot bearing forces and wear, improved intravascular conduits with increased resistance to thrombosis, conduit insertion site cuffs to resist infection, and conduit side ports amenable to the easy insertion of guidewire and catheter-based medical devices.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: May 30, 2017
    Assignee: FLOW FORWARD MEDICAL, INC.
    Inventors: F. Nicholas Franano, Howard M. Loree, II, Geoff Tansley, Steve Woodard, Barrett Hutto
  • Patent number: 9662432
    Abstract: A novel arterial cannula tip includes an elongated body having an expanded four-lobe swirl inducer and a diverging diffuser. The swirl inducer presents micro-scale blood-wetting features that help to enhance the jet or core of the flow of blood sufficiently to delay the onset of turbulence and facilitate a strongly coherent blood outflow jet as it enters the cannulated artery, while the diverging diffuser reduces exit force and promotes and laminar flow which mitigates intimal vascular damage owing to high wall shear stresses at regions of jet impingement. When used in conjunction with an aortic cannula, the device facilitates neuroprotection by way of improved cerebral perfusion.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: May 30, 2017
    Assignee: Carnegie Mellon University
    Inventors: Prahlad Menon Gopalakrishna, Kerem Pekkan
  • Patent number: 9662433
    Abstract: A pressure detection device of a liquid flow route is provided which detects a pressure of an arterial blood circuit consisting of a flexible tube, a portion of which is connected to a peristaltically-actuated tube that can cause an internal liquid to flow by being compressed in a radial direction and being peristaltically actuated in a longitudinal direction in a roller of a blood pump, and which enables a predetermined liquid to be circulated. The pressure detection device includes a load sensor that detects radial displacement of the peristaltically-actuated tube.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: May 30, 2017
    Assignee: NIKKISO COMPANY LIMITED
    Inventors: Sumiaki Matsuo, Kazumi Yokoyama, Kunihiko Akita
  • Patent number: 9662434
    Abstract: A surgical blower for providing a directed stream to clear a surgical site, that can be used in multiple different use modes. In one use mode, the surgical blower is handheld by a user during operation. In another mode, a distal end portion of the blower is fixed to a foot of a stabilizer instrument and the handle of the blower is handheld. In another mode, a distal end portion of the blower is fixed to a foot of a stabilizer instrument and the handle of the blower is fixed to a stationary object such as a sternal retractor. In another mode, the distal end of the blower is free and the handle of the blower is fixed to a stationary object. An apparatus including a blower and a stabilizer is provided. Methods of using the blower as well as the apparatus are also provided.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: May 30, 2017
    Assignee: MAQUET CARDIOVASCULAR LLC
    Inventors: Amit Agarwal, Michael C. Stewart, Albert K. Chin
  • Patent number: 9662435
    Abstract: A method for using CO2 as a contrast material in medical imaging procedures is disclosed. The method includes providing a source of pressurized CO2. The step of providing includes connecting the source of pressurized CO2 to a compressed gas unit for controlling delivery of the CO2. The method also includes regulating pressure of the CO2 delivered by the compressed gas unit, transmitting the pressurized CO2 from the compressed gas unit to a control valve assembly for delivery to a patient in controlled dosages, and sequentially processing the CO2 with the control valve assembly and delivering the CO2 to the patient as a contrast media.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: May 30, 2017
    Inventors: Frank Levy, Kimberley Levy
  • Patent number: 9662436
    Abstract: A fail-safe drug infusion system, including a user interface controller (UIC) and at least one pump motor controller (PMC), with protocols that enable the PMC to operate therapy delivery for a limited amount of time if the UIC fails or the communication link between the UIC and the PMC is interrupted. Includes synchronization methods to synchronize the delivery information back to the UIC after the UIC reboots or after the communication link is restored. The PMC may apply intelligent fail-safe drug infusion therapy by temporarily displaying therapy information, for example information normally displayed by the UIC, while taking control of alarm signaling and providing minimal user control of the therapy until the UIC restores itself, the infusion completes normally, or the user stops the infusion. If the PMC becomes inoperable, the UIC may wait for the PMC to reboot, or attempt to switch infusion channels to provide robust drug infusion.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: May 30, 2017
    Assignee: ICU Medical, Inc.
    Inventors: Anatoly S. Belkin, William K. Day, Steve J. Lindo, James P. Roman, Andrei T. Stratan
  • Patent number: 9662437
    Abstract: A pressure plate is configured to be coupled to a control module of an infusion pump. First and second securing hooks may extend away from a major surface of the pressure plate proximally to a first end. Each of the securing hooks may be structured to reversibly and hingedly couple to a hinge pin of the control module. An arch may extend away from the major surface proximally to a second transverse end and be structured to be received by a latch receptacle of the control module. The pressure plate may be secured to the control module by the securing hooks and arch. Each of the securing hooks may include a bearing surface configured to bear against a hinge pin when the pressure plate is secured to the control module, each bearing surface being parallel along the longitudinal axis with respect to the first major surface to within five degrees.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: May 30, 2017
    Assignee: Smiths Medical ASD, Inc.
    Inventor: Shiva Moosai
  • Patent number: 9662438
    Abstract: A medical device system is disclosed. The medical device system includes a first medical device and a second medical device. A remote interface including a touch screen is also included. The remote interface is in wireless communication with the first medical device and the second medical device. The remote interface is configured to provide a user interface to the first medical device and the second medical device. The remote interface is configured to receive user input through a touch screen. Also, a charging device is included. The charging device is configured to receive at least the first medical device and the remote interface and the charging device is configured to recharge a first medical device battery and the charging device is configured to recharge an interface battery in the remote interface. The charging device is connected to a personal computer wherein the personal computer provides information to the remote interface.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: May 30, 2017
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, John M. Kerwin, Kevin A. Durand, Gregory R. Lanier, Jr., Larry B. Gray, Gregg W. Rivinius, Gerald M. Guay, Bob D. Peret, Colin H. Murphy, David Blumberg, Jr.
  • Patent number: 9662439
    Abstract: The invention concerns an device for injecting a patient with a liquid product contained in a container (4), the system comprising a pressurizing unit for driving the liquid product contained in the container, the system further comprising a calculator for estimating the injection flow rate at the outlet of the container, said injection flow rate at the outlet being estimated on the basis of a law of deformation of the system under the effect of the pressure inside the container.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: May 30, 2017
    Assignee: Medex
    Inventors: Habib Rebergue, Adriana Murillo, Ali Dghoughi
  • Patent number: 9662440
    Abstract: Embodiments of the present invention are directed to devices, systems and methods for delivering therapeutic fluid (e.g., insulin) into the body, including a skin adherable cradle, for retaining a therapeutic fluid dispenser for delivering a therapeutic fluid to a user.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: May 30, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Gavriel J. Iddan, Avraham Neta
  • Patent number: 9662441
    Abstract: A one-piece connector for removing a housing and needle of a Huber needle assembly from a patient. The connector has a frame that can be positioned about a surface on the housing of the needle assembly and a pair of wings that pivot toward one another to provide a gripping surface.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: May 30, 2017
    Assignee: Bard Access Systems, Inc.
    Inventors: Michael J. Vaillancourt, Marshall Kerr
  • Patent number: 9662442
    Abstract: The present invention relates to a linear flow regulating apparatus for intravenous infusion, and more particularly, to a flow regulating apparatus which is used in an infusion set for intravenous infusion to regulate the flow rate of a solution injected into a body. To eliminate the difficulties caused by the nonlinearity of conventional flow regulating apparatuses, which regulate flow rates by pressing a solution flow tube to adjust the flow passage area, the linear flow regulating apparatus has a control unit to be put in or taken out along the width of a flow channel unit through which the solution flows when the height and length of the flow channel unit are fixed, and is capable of linearly regulating the flow rate by varying the flow passage area of the flow channel unit by adjusting the width of a flow channel unit.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 30, 2017
    Assignee: KOREA INSTITUTE OF MACHINERY & MATERIALS
    Inventors: Eui-Soo Yoon, Moo-Ryong Park, Bum Seog Choi, Jun Young Park, Il-Su Yoo, Jeong Min Seo, Soon-Chan Hwang
  • Patent number: 9662443
    Abstract: An alert device for use with an intravenous drip, comprises two induction ends and a control unit. The control unit comprises a circuit module, an alarm module and a power module. The two induction ends are located on a pipe of the intravenous drip and are contacting with an injection solution inside the pipe. The two induction ends are electrically connected to the control unit by wires. The circuit module detects the induction ends to determine whether the induction ends are in an open-loop status or not. The circuit module connects to the alarm module. The power module supplies power for the control unit. The induction ends uses the injection solution as a conducting means to form an electrically closed loop; when the induction ends do not contact with the injection solution, the induction ends become an open-loop, and thus the alarm module generates alarm signals.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: May 30, 2017
    Inventor: Richard Hwang
  • Patent number: 9662444
    Abstract: A medical fluid infusion system includes a pump system configured to deliver a fluid drug to a patient. The system includes a device and method for detecting when the level of a fluid in a fluid supply container (such as an IV bag) is exhausted or near exhausted.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: May 30, 2017
    Assignee: CareFusion 303, Inc.
    Inventors: Adam Reaves, Lee Good, Pete Heffron
  • Patent number: 9662445
    Abstract: An electronic controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop initiation module. The initiation module is operated to obtain a most recent calibration factor for a continuous glucose sensor, the most recent calibration factor representing a first conversion value applicable to convert a first sensor value to a first blood glucose value. The initiation module also obtains a prior calibration factor for the sensor, and calibration timestamp data for the most recent calibration factor and the prior calibration factor. The initiation module regulates entry into a closed-loop operating mode of the insulin infusion device, based on the most recent calibration factor, the prior calibration factor, and the calibration timestamp data.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: May 30, 2017
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Neha J. Parikh, Anirban Roy, Desmond Barry Keenan, John J. Mastrototaro, Benyamin Grosman
  • Patent number: 9662446
    Abstract: Provided is a pericardial-liquid level control system with which a good viewing field can be ensured for an endoscope image without causing cardiac tamponade. A pericardial-liquid level control system is employed, including a sheath that is inserted into the pericardium; pumps that supply and expel liquid to and from the sheath; electrocardiogram electrodes that detect electrocardiographic information; and a pump control device that, in synchronization with the electrocardiographic information detected by the electrocardiogram electrodes, controls the pumps so that the liquid is supplied to the pericardium via the sheath during contraction of the heart and the liquid is expelled from the pericardium via the sheath during expansion of the heart.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: May 30, 2017
    Assignee: OLYMPUS CORPORATION
    Inventor: Hiroshi Fukuda
  • Patent number: 9662447
    Abstract: An autoinjector having a lower body (10) receiving a reservoir, a piston, a needle, a central body (1) fixed to the lower body, an actuating sleeve (11) having a contact end to contact the body of the user and displaceable in the lower body between a projected position, in which the actuating sleeve at least partially projects out of the lower body and an actuation position, in which the actuating sleeve is axially displaced towards the interior of the lower body. The actuating sleeve includes a flexible tab (110) adapted to deform on the one hand radially and on the other hand laterally relative to the central body when the actuating sleeve is displaced from its projected position towards its actuation position then from its return actuation position towards its projected position.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: May 30, 2017
    Assignee: APTAR FRANCE SAS
    Inventors: David Fabien, Antoine Mansencal, Matthieu Walter
  • Patent number: 9662448
    Abstract: The present invention relates to a medicament delivery device comprising a housing (10), which housing (10) is arranged ranged to accommodate a medicament container (16), the device further comprises a drive mechanism (18) capable of, upon activation, expel a dose of medicament from said medicament container, the drive mechanism comprising a flat spiral spring (26). The invention is characterized in that at least a part (36) of an outermost turn of said flat spiral spring (26) is positioned on an outer surface of said housing (10).
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: May 30, 2017
    Assignee: Carebay Europe Ltd
    Inventor: Anders Holmqvist