Abstract: An apparatus is described for measuring surface topography of a three-dimensional structure. In many embodiments, the apparatus is configured to focus each of a plurality of light beams to a respective fixed focal position relative to the apparatus. The apparatus measures a characteristic of each of a plurality of returned light beams that are generated by illuminating the three-dimensional structure with the light beams. The characteristic is measured for a plurality of different positions and/or orientations between the apparatus and the three-dimensional structure. Surface topography of the three-dimensional structure is determined based at least in part on the measured characteristic of the returned light beams for the plurality of different positions and/or orientations between the apparatus and the three-dimensional structure.

Abstract: A confocal imaging apparatus includes an illumination module to generate an array of light beams. Focusing optics perform confocal focusing of an array of light beams onto a non-flat focal surface and direct the array of light beams toward a three dimensional object to be imaged. A translation mechanism adjusts a location of at least one lens to displace the non-flat focal surface along an imaging axis. A detector measures intensities of an array of returning light beams that are reflected off of the three dimensional object and directed back through the focusing optics. Intensities of the array of returning light beams are measured for locations of the at least one lens for determination of positions on the imaging axis of points of the three dimensional object. Detected positions of one or more points are adjusted to compensate for the non-flat focal surface.

Abstract: The invention relates to a method for designing a plurality of adjacent tooth restorations using CAD/CAM technology. In a first step, the virtual model of a first tooth restoration at the first border of the restoration site is designed. In a second step, the virtual model of the second tooth restoration adjacent to the first tooth restoration is designed, the second tooth restoration being adjusted to match the first tooth restoration. The virtual model of the first tooth restoration is adjusted in relation to the second tooth restoration in a third step, if required. This procedure is then repeated for all of the other tooth restorations in the restoration site.

Abstract: A method for manufacturing a removable dental prosthesis using a three-dimensional (3D) printer includes receiving dental impressions of a patient obtained using a dental impression tray assembly, the dental impressions including a bite registration and at least a mandibular impression or a maxillary impression; receiving information related to the patient's jaw relations obtained using the dental impression tray assembly, the jaw relations including a vertical dimension and a centric relation obtained during the patient's single visit to a dentist; scanning the received dental impressions with a 3D scanner to provide data representative of an edentulous shape of the patient; generating a 3D model of the dental prosthesis based on the data and the received information related to the patient's jaw relations using 3D design software; displaying the generated 3D model on a display, allowing customization of the 3D model; and 3D printing the dental prosthesis according to the 3D model.

Abstract: Adapters and dental mill blanks are provided which permit use of dental mill blanks of various shapes in dental mills designed for use with only a single shape. In particular, a mill blank assembly may include an adapter which allows for the use of rectangular, framed dental blanks in milling machines designed for use with puck-like milling blanks.

Abstract: A system for attaching a natural tooth to a dental implant includes a dental prosthesis and an elastomeric cushion. The elastomeric cushion is positioned in contact, either directly or indirectly, with at least a portion of the dental implant and at least a portion of the dental prosthesis such that the elastomeric cushion permits movement of the dental prosthesis relative to the dental implant in response to movement of the natural tooth transferred through the dental prosthesis.

Abstract: A luminescent coating is disclosed that is used to dimensionally control the curing of a photocurable agent placed in close contact with the coating. The coating is applied at the interface of structures, such as brackets and prosthetics, or may be applied directly on a curable material for use in 3D printing, at the location where bonding material is needed to be cured. The luminescent coating irradiates from its structure the curing radiations necessary to photopolymerize the resin in response to a first radiation irradiated on its structure of a different wavelength.

Abstract: Systems, method, and devices related to surgically implantable supportive slings are presented herein. More specifically, in various embodiments, the systems, devices and methods relate to a surgically implantable supportive sling adapted to anchor in patient tissue.

Abstract: An apparatus for treating urinary incontinence, comprising: (a) a support section adapted for providing urethral support; (b) an anchoring section adapted for resisting movement of the apparatus; (c) a normally open expansion mechanism adapted to urge the support radially outwards; and (d) a conversion mechanism adapted to sharply and selectively reduce an outward urging of said support.

Abstract: There is disclosed embodiments of a vascular filter having, among other things, a plurality of discrete segments, each having two or more loops and an extension. The loops of each segment can be connected to form a dome or conical shaped end with an unblocked central opening. Prongs and beads may be provided to enhance visualization and anchoring in a vessel. Methods for inserting and moving or removing the filter from the vessel are also disclosed.

Abstract: A stent-graft comprises a substantially tubular graft material, and a stent coupled to the graft material. The stent has proximal and distal ends and further has compressed and deployed states. The proximal end is disposed proximally beyond a proximal edge of the graft material, and the distal end has at least one portion overlapping with the proximal edge of the graft material. In one example, the stent comprises at least one distal apex having a bifurcation extending into first and second leg regions. A distal end of the first leg region is positioned to overlap the graft material at a location circumferentially spaced apart from a location at which a distal end of the second leg region overlaps the graft material in the deployed state.

Abstract: The invention relates to a band-like structure for the augmentation of a ligament, comprising a central section for fastening to an organ of the true pelvis, said central section having a central knit fabric with a central warp direction, a lateral section for fastening to a suspension surface and a plurality of threads, which are connected to the central section and the lateral section. It is proposed that the central knit fabric comprises the plurality of threads.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: An optimized breast implant injector includes a hollow tube body and a plunger. The hollow tube body has a short tube reducer at one end and a circular disk at the other end. The plunger includes a push block, a driving device, and two fixed covers. The outer surface of the push block appears to be a circular arc shape. The driving device includes a rotating part, and a driving gear, a driven gear and a rack that mesh together. A user uses the rotating part to easily start the driving gear, the driven gear, and the rack, in order to let the rack drive the push block to move the breast implant in the hollow tube body. Through operating a short tube reducer of the hollow tube body and the push block, the breast implant can be pushed through from the short tube reducer easily.

Abstract: An ophthalmic lens comprising a stacked integrated component device can provide various functionality. The stacked integrated component device may contain an energy source capable of powering an electrical component incorporated into the lens.

Abstract: Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically sealed within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10?12 Pa m3s?1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.

Abstract: An intraocular lens (31) which may be used as a posterior lens in a lens train including a converging anterior lens (20) and diverging posterior lens (31) in which the optical/focal axes of the two lenses are not coincident such that the focal point (9) of the lens train is offset from the focal axis of the anterior lens. Light rays (50) incident upon the anterior lens parallel to its focal axis may thus be directed (51) to parts of the retina offset from the fovea where the macula may not have degenerated.

Abstract: Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the medial portions. Either the medial portion or the lateral portion can be adjustable in two dimensions which are not parallel to the length of the strut, which can also be adjustable. In some embodiments, the medial portion and/or the lateral portion can each comprise two adjustable arms and a base member which has a curvilinear configuration.

Abstract: A method to treat glottic insufficiency includes creating a window in a thyroid cartilage and inserting an implant through the window and into a paraglottic space. The implant includes a balloon with a port connector and a band comprising a proximate end attached to a portion of the balloon. The method further includes securing the band to a thyroarytenoid muscle complex and inflating the balloon to pull on the band, which in turn pulls on the thyroarytenoid muscle, which in turn rotates an arytenoids cartilage to medialize and tighten a vocal cord.

Abstract: A tool for facilitating insertion of a speech valve with a flexible retention flange into a fistula between the trachea and the esophagus of a human patient. The tool has a wall curved to define a passage having opposed open first and second passage ends and an axis extending therebetween. The wall has an external surface insertable into a fistula between the trachea and esophagus and defining a slot which extends from the passage to the external surface of the wall. The slot has an opening at the first passage end extending from the first passage end to at least a part of the way to the second passage end and at least a portion of the slot progresses angularly around the axis.

Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.

Abstract: The pericardial heart valve replacement (1) is constructed from living tissue of autologous pericardium containing living pericardial interstitial cells (PICs) and a living extracellular matrix (ECM) in the following way: in the first step the size and shape of the patient's native pathological heart valve is determined using real-time three-dimensional transesophageal echocardiography (TEE) or computer tomography (CT angiography) or magnetic resonance imaging (MRI); in the next step a stented (2) or a stentless pericardial heart valve replacement (1) is constructed from a single sheet of living autologous pericardium obtained from the patient; the size and shape of the pericardial heart valve replacement (1) corresponds to the size and shape of the patient's native heart valve and aortic or pulmonary root.

Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

Abstract: Implantable prosthetic valves are disclosed, methods of their use, and related fabrication techniques are disclosed. In some cases, the prosthetic valves disclosed herein can include frame, skirt, and valve components. The frame component can have an overall, generally scalloped shape comprising fewer struts and fabricated from less raw material than known frames. In some cases, the prosthetic valves disclosed herein can be crimped to a smaller diameter than can other known valves.

Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

Abstract: This invention relates to a delivery apparatus and method for deployment of a mitral valve replacement.

Abstract: A prosthetic heart valve having an internal support frame with a continuous, undulating leaflet frame defined therein. The leaflet frame has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. The leaflet frame may be cloth covered and flexible leaflets attached thereto form occluding surfaces of the valve. The support frame further includes three cusp positioners rigidly fixed with respect to the leaflet frame and located at the outflow end of the support frame intermediate each pair of adjacent commissure regions. The valve is desirably compressible so as to be delivered in a minimally invasive manner through a catheter to the site of implantation. Upon expulsion from catheter, the valve expands into contact with the surrounding native valve annulus and is anchored in place without the use of sutures.

Abstract: A delivery system for percutaneously deploying a valve prosthesis. The system includes a catheter assembly including a delivery sheath capsule and a handle having an oscillating device. The capsule is configured to compressively retain the valve prosthesis during implantation. After the valve prosthesis is partially exposed during implantation, the oscillating device can create a vibratory motion to reduce the friction between the valve prosthesis and the delivery sheath capsule in order to recapture the valve prosthesis.

Abstract: Methods and devices are disclosed for treating neurovascular venous outflow obstructions, with or without implantation of a prosthetic valve. The valve may be carried by a support, such as a stent, which may be self-expandable or balloon expandable. Both transvascular and direct surgical access is contemplated.

Abstract: Methods and devices for controlling blood perfusion pressure along with regional mild hypothermia. In at least one embodiment of a device for controlling blood perfusion pressure within a vessel of the present disclosure, the device comprises an elongated body having a lumen, a proximal end configured for placement in a first area having a first blood pressure, and a distal end configured for placement in a second area having a second blood pressure, a partial occluder positioned within the lumen of the elongated body between the proximal end and the distal end, the partial occluder configured so not to fully occlude a blood vessel and to equalize the first blood pressure at the first area with the second blood pressure at the second area, and a regional hypothermia system operably coupled thereto, the regional hypothermia system operable to reduce and/or regulate a temperature of a bodily fluid flowing therethrough.

Abstract: To manufacture the implant a nanopowder of synthetic hydroxyapatite (Hap) is used having a hexagonal structure, average grain size in a range from 3 to 30 nm and the specific surface area greater than 200 m2/g. First the nanopowder is formed to the desired geometric shape, and then the shape is fixed. In the step of shape information the dried nanopowder is pressed in the mold under the pressure ranging from 50 Mpa to 2 GPa. In the step of fixing the pressed nanopowder at room temperature is subjected to the pressure rising from the ambient value to the peak value selected from a range of 1 to 8 GPa and to a temperature selected from a range of 100° C. to 600° C. for a period of time selected from a range from 30 seconds to 5 minutes. The density of thus produced implant, determined by helium method, is not less than 75% of the theoretical density.

Abstract: An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

Abstract: A method of designing a prosthetic implant. Exemplary methods may include developing a three-dimensional model of an anatomic feature from one or more two-dimensional images. The three-dimensional model may include a plurality of radii of curvature representing the shape of respective portions of a contact surface. In some exemplary embodiments, three-dimensional models associated with a large number members of a population may be utilized to create templates for prosthetic implants. A three-dimensional model of an anatomic feature of a patient may be compared to the available templates, and a suitable template may be tested by virtually implanting the template on the three-dimensional model of the patient's anatomical feature. In some embodiments, a patient's three-dimensional model for which a suitable pre-made template is not available may be used to customize a pre-made template to design a suitable implant.

Abstract: An intermediate body is for a bone implant for replacement of an osseous area. The intermediate body has a base body and a seat which extends axially in the base body and is surrounded by a wall of the base body. The intermediate body is designed to receive and surround an end portion of an intramedullary implant part. A clamp device is assigned to the seat. A clamp component is arranged on the wall of the base body surrounding the seat. In order to clamp, the end portion is inserted beforehand into the seat relative to the wall of the base body. The wall then surrounds the seat and the inserted end portion is movable towards the seat and in the process clamps the end portion in the seat. An implant arrangement is provided with the intermediate body.

Abstract: A patello-femoral prosthesis is provided for replacing the engagement surfaces between the patella and the femur. The prosthesis is configured to cover the trochlear groove and extend into the intercondylar notch without extending onto the articulating surfaces of the condyles. A method is also provided for implanting a patello-femoral prosthesis in which a portion of the trochlear groove and intercondylar notch are resected and the prosthesis is implanted over the femur that had portions resected.

Abstract: A tibial tray system includes a tibial tray configured for attachment to a surgically-prepared surface of the proximal end of the tibia. The tibial tray includes a track disposed in a generally A-P direction. The tibial tray system also includes a spline configured to engage the track and to be positionable in at least one location along the track. The spline includes a bearing surface that is configured to contact a femoral component of the knee prosthesis to guide movement of the femoral component during extension and flexion of the knee.

Abstract: Stand-alone interbody fusion devices for engagement between adjacent vertebrae. The stand-alone interbody fusion devices may include a spacer and one or more inserts or members coupled to the spacer. The inserts or members may be configured and designed to provide the apertures which are designed to retain bone fasteners, such as screws, and secure the implant to the adjacent vertebrae.

Abstract: The present application relates to an expandable spinal implant comprising three or more elongated implant members. The implant members are rotatably coupled to a central base portion and comprise a first end with an axis of rotation and circumferentially arranged gear teeth. The gear teeth of at least one of said elongated implant members are interlocked into said gear teeth of the two other elongated implant members.

Abstract: The present invention provides an intervertebral implant for implantation in a treated area of an intervertebral space between vertebral bodies of a spine. The implant includes a spacer portion having an inferior and superior surface, wherein the inferior and superior surfaces each have a contact area capable of engaging with anatomy in the treated area, and the inferior and superior surfaces define a through-hole extending through the spacer body. The present invention further provides screw holes extending from a side portion to the inferior and superior surfaces of the spacer portion and a plate portion rigidly coupled to the spacer portion through a coupling means, wherein the plate portion contains screws holes for receiving screws. A screw back out prevention mechanism adapted on the plate portion and prevents the back out of screws from the screw holes.

Abstract: A spinal insert device adjusts inter-vertebral spacing and alignment of the spine relative to pelvic incidence, pelvic tilt and overall sagittal alignment. The device includes an upper arm having a substantially planar upper surface and a lower arm having a substantially planar lower surface. Each of the upper arm and the lower arm extends outwardly from a base section. A hinge couples the upper arm to the base section such that the upper arm is pivotable relative to the base section. An adjustment member is positioned between the upper arm and the lower arm. The adjustment member has a plurality of distinct lengths measured straight through a center of the adjustment member. The adjustment member is rotatable wherein an angle between the upper arm and the lower arm is selectively adjustable by rotation of the adjustment member.

Abstract: An expandable interbody fusion device includes superior and inferior plates that are configured to receive a sequentially inserted stack of expansion members or wafers. The superior and inferior plates include features that at least initially interlock the two plates until the superior plate is dislodged by pressure from the growing wafer stack. The wafers include features on their top and bottom surfaces that interlock the wafers in multiple degrees of freedom so that the wafer stack is not disrupted when the fusion device is fully expanded. Each wafer also includes features that interlock with the inferior plate until the wafer id dislodged by sequential introduction of another wafer.

Abstract: An expandable spinal prosthesis is disclosed, including a first surface having a first plurality of tissue anchors; a second surface opposite the first surface, the second surface having a second plurality of tissue anchors; a first wall between the first and second surfaces, and a second wall between the first and second surfaces, the second wall located opposite the first wall and being movable with respect to the first wall. A surgical instrument is also provided, including an elongated shaft defining a proximal end and a distal end; a first prosthesis engagement element accessible from the proximal end and extending from the distal end; and a second prosthesis engagement element accessible from the proximal end and extending from the distal end, the second prosthesis engagement element including a plurality of gear teeth.

Abstract: Improved assessment probes and measuring tools, systems, procedures and methods to facilitate the selection and/or implantation of prosthetic joint components, and assist a surgeon or medical practitioner with the proper assessment, balancing and/or restoration of natural and/or desired joint kinematics during a joint replacement procedure.

Abstract: A mounting plate system for use with a prosthetic socket includes a mounting plate having a cylindrical configuration. The mounting plate includes a top face arranged to be adjacent to a distal outer periphery of the prosthetic socket and a bottom face for attachment to a prosthetic limb. An opening extends from the top face to the bottom face. A bottom recess has a cylindrical configuration and extends from the bottom face and surrounds the opening. A top recess has a cylindrical configuration and extends from the top face and surrounds the opening.

Abstract: A stent has a first end region, a middle region, and a second end region, each region including a plurality of strut columns. The stent includes at least one barb. Each barb in an expanded state is at an angle relative to the outer surface of the stent.

Abstract: A vascular device comprising a plurality of vessel engaging members and a valve. The device is movable from a collapsed insertion position having a first diameter to a second expanded position having a second diameter larger than the first diameter. The plurality of vessel engaging members extend outwardly from the device for securely engaging the internal wall of a vessel upon expansion of the device to the second expanded position, wherein the vessel engaging members pull the internal wall of the vessel radially inwardly upon movement of the device from the second expanded position toward a first expanded position having a third diameter greater than the first diameter and less than the second diameter. In the first expanded position the valve is movable between an open position to allow blood flow therethrough to a closed position to prevent blood flow.

Abstract: Medical devices and method for making and using the same are disclosed. An example medical device may include implantable medical device for use along the biliary and/or pancreatic tract. The implantable medical device may include a tubular member having a first end configured to be disposed within the duodenum of a patient and a second end configured to be disposed adjacent to a pancreatic duct and/or bile duct. The tubular member may have a body including one or more wire filaments that are woven together. The tubular member may also have an outer surface with a longitudinal channel formed therein.

Abstract: Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.

Abstract: A welded stent and stent delivery system, with a stent including a first strut having a first strut nickel titanium alloy layer and nickel titanium soluble core, the first strut nickel titanium alloy layer being disposed around the first strut nickel titanium soluble core; and a second strut having a second strut nickel titanium alloy layer and nickel titanium soluble core, the second strut nickel titanium alloy layer being disposed around the second strut nickel titanium soluble core, the second strut nickel titanium alloy layer being connected to the first strut nickel titanium alloy layer with a weld. The first and second strut nickel titanium alloy layers are made of a nickel titanium alloy, the first and second strut nickel titanium soluble cores are made of a nickel titanium soluble material, and the weld is made of an alloy of the nickel titanium alloy and the nickel titanium soluble material.

Abstract: Methods of making polymeric devices, such as stents, using solvent based processes. More particularly, methods of making bioabsorbable stents.